Interactions of pharmaceuticals and other xenobiotics on hepatic pregnane X receptor and cytochrome P450 3A signaling pathway in rainbow trout (Oncorhynchus mykiss)

Aquatic Toxicology

Volumn 100, Issue 1, 2010, Pages 91-100

  Wassmur, Britt ^a   Gräns, Johanna ^a   Kling, Peter ^a   Celander, Malin C ^a  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

Author keywords

CYP3A; Fish; Nuclear receptors; P glycoprotein; Pharmaceuticals; PXR

Indexed keywords

16ALPHA CYANOPREGNENOLONE; CELL NUCLEUS RECEPTOR; CYTOCHROME P450 3A; DEXAMETHASONE; GLYCOPROTEIN P; KETOCONAZOLE; LITHOCHOLIC ACID; MESSENGER RNA; OMEPRAZOLE; PREGNANE X RECEPTOR; RIFAMPICIN; XENOBIOTIC AGENT; STEROID RECEPTOR;

CYTOCHROME; DNA; DRUG; ECOTOXICOLOGY; ENZYME ACTIVITY; HORMONE; RNA; SALMONID; XENOBIOTICS;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CANCER CELL CULTURE; CATALYST; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; FEMALE; GENE EXPRESSION REGULATION; HEPATOMA CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; JUVENILE ANIMAL; LIVER CELL CULTURE; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RAINBOW TROUT; SIGNAL TRANSDUCTION; TOXICITY TESTING; ANIMAL; CELL LINE; DRUG EFFECT; ENZYMOLOGY; GENE EXPRESSION; GENETICS; LIVER; LIVER CELL; METABOLISM; WATER POLLUTANT;

ANIMALIA; ONCORHYNCHUS MYKISS; XENOPHORA;

ANIMALS; CELL LINE; CYTOCHROME P-450 CYP3A; GENE EXPRESSION; HEPATOCYTES; LIVER; ONCORHYNCHUS MYKISS; P-GLYCOPROTEIN; RECEPTORS, STEROID; RNA, MESSENGER; SIGNAL TRANSDUCTION; WATER POLLUTANTS, CHEMICAL; XENOBIOTICS;

EID: 77957591569     PISSN: 0166445X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.aquatox.2010.07.013     Document Type: Article

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