Activation of a tunicate (Ciona intestinalis) xenobiotic receptor orthologue by both natural toxins and synthetic toxicants

Toxicon

Volumn 59, Issue 2, 2012, Pages 365-372

  Fidler, Andrew E ^a,b   Holland, Patrick T ^a   Reschly, Erica J ^c   Ekins, Sean ^d   Krasowski, Matthew D ^c,e  

^a CAWTHRON INSTITUTE   (New Zealand)

^b UNIVERSITY OF AUCKLAND   (New Zealand)

^c UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^d Collaborations in Chemistry ^*  (United States)

^e UNIVERSITY OF IOWA HOSPITALS AND CLINICS   (United States)

Author keywords

Biotoxins; Ciona intestinalis; Nuclear receptor; Pharmacophore; Pregnane X receptor; Tunicate; Vitamin D receptor; Xenobiotic

Indexed keywords

FARNESOID X RECEPTOR; FENVALERATE; LIVER X RECEPTOR; MARINE TOXIN; OKADAIC ACID; PECTENOTOXIN; PREGNANE X RECEPTOR; UNCLASSIFIED DRUG; VITAMIN D RECEPTOR;

ARTICLE; BINDING AFFINITY; CIONA INTESTINALIS; CONTROLLED STUDY; HUMAN; HUMAN CELL; HYDROGEN BOND; HYDROPHOBICITY; LIGAND BINDING; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN INTERACTION; RECEPTOR UPREGULATION;

ANIMALS; CIONA INTESTINALIS; EVOLUTION, MOLECULAR; GENES, REPORTER; HUMANS; LIGANDS; LUCIFERASES; MARINE TOXINS; MICROALGAE; MODELS, MOLECULAR; PESTICIDES; PROTEIN BINDING; RECEPTORS, CALCITRIOL; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, STEROID; XENOBIOTICS;

CHORDATA; CIONA INTESTINALIS; DANIO RERIO; INVERTEBRATA; VERTEBRATA;

EID: 84855424875     PISSN: 00410101     EISSN: 18793150     Source Type: Journal    
DOI: 10.1016/j.toxicon.2011.12.008     Document Type: Article

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