Unraveling the role of protein dynamics in dihydrofolate reductase catalysis

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 41, 2013, Pages 16344-16349

  Luk, Louis Y P ^a   Ruiz Pernía, J Javier ^b   Dawson, William M ^a   Roca, Maite ^b   Loveridge, E Joel ^a   Glowacki, David R ^c   Harvey, Jeremy N ^c   Mulholland, Adrian J ^c   Tuñón, Iñaki ^d   Moliner, Vicent ^b   Allemann, Rudolf K ^a,b  

^a CARDIFF UNIVERSITY   (United Kingdom)

^b UNIVERSITAT JAUME I   (Spain)

^c UNIVERSITY OF BRISTOL   (United Kingdom)

^d UNIVERSITY OF VALENCIA   (Spain)

Author keywords

Biological chemistry; Biophysics; Computational chemistry; Kinetics; Quantum biology

Indexed keywords

DIHYDROFOLATE REDUCTASE; DIHYDROFOLIC ACID; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; CARBON; NITROGEN; PROTEIN; TRITIUM;

ARTICLE; CATALYSIS; CIRCULAR DICHROISM; MOLECULAR DYNAMICS; MOLECULAR MECHANICS; MOLECULAR WEIGHT; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PH; PRIORITY JOURNAL; PROTEIN STRUCTURE; SIMULATION; CHEMICAL STRUCTURE; ENZYMOLOGY; ESCHERICHIA COLI; KINETICS; METABOLISM;

CARBON ISOTOPES; CATALYSIS; ESCHERICHIA COLI; KINETICS; MODELS, MOLECULAR; MOLECULAR DYNAMICS SIMULATION; NITROGEN ISOTOPES; PROTEINS; TETRAHYDROFOLATE DEHYDROGENASE; TRITIUM;

EID: 84885351843     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1312437110     Document Type: Article

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