Heavy-enzyme kinetic isotope effects on proton transfer in alanine racemase

Journal of the American Chemical Society

Volumn 135, Issue 7, 2013, Pages 2509-2511

  Toney, Michael D ^a   Castro, Joan Nieto ^a   Addington, Trevor A ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE RACEMASE; BARRIER CROSSING; CATALYTIC EFFECTS; COUPLED MOTIONS; D ALANINES; GEOBACILLUS STEAROTHERMOPHILUS; GEOMETRIC MEAN; KINETIC ISOTOPE EFFECTS; PROTON TRANSFER REACTIONS; RATE-LIMITING STEPS; VIBRATIONAL MOTIONS;

CARRIER MOBILITY; DEUTERIUM; ENZYMES; PROTEINS; REACTION KINETICS; SUBSTRATES;

AMINO ACIDS;

ALANINE; ISOTOPE; RACEMASE;

ARTICLE; ENZYME ACTIVITY; GEOBACILLUS STEAROTHERMOPHILUS; GEOMETRY; KINETICS; MOTION; NONHUMAN; PROTEIN TRANSPORT; PROTON TRANSPORT;

ALANINE RACEMASE; DEUTERIUM; GEOBACILLUS STEAROTHERMOPHILUS; KINETICS; MOLECULAR STRUCTURE; PROTONS;

EID: 84874050462     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja3101243     Document Type: Article

References (41)

1. Schwartz, S. D.; Schramm, V. L. Nat. Chem. Biol. 2009, 5, 551
2. Zhang, J.; Klinman, J. P. J. Am. Chem. Soc. 2011, 133, 17134
3. Adamczyk, A. J.; Cao, J.; Kamerlin, S. C.; Warshel, A. Proc. Natl. Acad. Sci. U.S.A. 2011, 108, 14115
4. Klinman, J. P. Nat. Chem. 2010, 2, 907
5. Kamerlin, S. C.; Sharma, P. K.; Chu, Z. T.; Warshel, A. Proc. Natl. Acad. Sci. U.S.A. 2010, 107, 4075
6. Kamerlin, S. C.; Warshel, A. J. Phys. Org. Chem. 2010, 23, 677
7. Henzler-Wildman, K. A.; Thai, V.; Lei, M.; Ott, M.; Wolf-Watz, M.; Fenn, T.; Pozharski, E.; Wilson, M. A.; Petsko, G. A.; Karplus, M.; Hubner, C. G.; Kern, D. Nature 2007, 450, 838
8. Henzler-Wildman, K. A.; Lei, M.; Thai, V.; Kerns, S. J.; Karplus, M.; Kern, D. Nature 2007, 450, 913
9. Klinman, J. P. Philos. Trans. R. Soc. London, Ser. B 2006, 361, 1323
10. Hammes-Schiffer, S.; Benkovic, S. J. Annu. Rev. Biochem. 2006, 75, 519
11. Gao, J.; Ma, S.; Major, D. T.; Nam, K.; Pu, J.; Truhlar, D. G. Chem. Rev. 2006, 106, 3188
12. Garcia-Viloca, M.; Gao, J.; Karplus, M.; Truhlar, D. G. Science 2004, 303, 186
13. Benkovic, S. J.; Hammes-Schiffer, S. Science 2003, 301, 1196
14. Bruice, T. C. Acc. Chem. Res. 2002, 35, 139
15. Phillipson, P. E. J. Mol. Biol. 1968, 31, 319
16. Rokop, S.; Gajda, L.; Parmerter, S.; Crespi, H. L.; Katz, J. J. Biochim. Biophys. Acta 1969, 191, 707
17. Han, R.; Coleman, J. E. Biochemistry 1995, 34, 4238
18. Silva, R. G.; Murkin, A. S.; Schramm, V. L. Proc. Natl. Acad. Sci. U.S.A. 2011, 108, 18661
19. Kipp, D. R.; Silva, R. G.; Schramm, V. L. J. Am. Chem. Soc. 2011, 133, 19358
20. Spies, M. A.; Toney, M. D. Biochemistry 2003, 42, 5099
21. Spies, M. A.; Toney, M. D. J. Am. Chem. Soc. 2007, 129, 10678
22. Spies, M. A.; Woodward, J. J.; Watnik, M. R.; Toney, M. D. J. Am. Chem. Soc. 2004, 126, 7464
23. Sun, S.; Toney, M. D. Biochemistry 1999, 38, 4058
24. Bevington, P. R. Data Reduction and Error Analysis for the Physical Sciences; McGraw-Hill: New York, 1969.
25. Griswold, W. R.; Castro, J. N.; Fisher, A. J.; Toney, M. D. J. Am. Chem. Soc. 2012, 134, 8436
26. Huskey, W. P. J. Phys. Org. Chem. 1991, 4, 361
27. Bigeleisen, J. J. Chem. Phys. 1955, 23, 2264
28. Dametto, M.; Antoniou, D.; Schwartz, S. D. Mol. Phys. 2012, 110, 531
29. Quaytman, S. L.; Schwartz, S. D. J. Phys. Chem. A 2009, 113, 1892
30. Saen-Oon, S.; Quaytman-Machleder, S.; Schramm, V. L.; Schwartz, S. D. Proc. Natl. Acad. Sci. U.S.A. 2008, 105, 16543
31. Saen-Oon, S.; Schramm, V. L.; Schwartz, S. D. Z. Phys. Chem. 2008, 222, 1359
32. Quaytman, S. L.; Schwartz, S. D. Proc. Natl. Acad. Sci. U.S.A. 2007, 104, 12253
33. Basner, J. E.; Schwartz, S. D. J. Am. Chem. Soc. 2005, 127, 13822
34. Antoniou, D.; Abolfath, M. R.; Schwartz, S. D. J. Chem. Phys. 2004, 121, 6442
35. Gertner, B. J.; Whitnell, R. M.; Wilson, K. R.; Hynes, J. T. J. Am. Chem. Soc. 1991, 113, 74
36. Gertner, B. J.; Wilson, K. R.; Hynes, J. T. J. Chem. Phys. 1989, 90, 3537
37. Gertner, B. J.; Bergsma, J. P.; Wilson, K. R.; Lee, S. Y.; Hynes, J. T. J. Chem. Phys. 1987, 86, 1377
38. Bergsma, J. P.; Gertner, B. J.; Wilson, K. R.; Hynes, J. T. J. Chem. Phys. 1987, 86, 1356
39. Nagel, Z. D.; Klinman, J. P. Chem. Rev. 2006, 106, 3095
40. Nagel, Z. D.; Klinman, J. P. Chem. Rev. 2010, 110, PR41
41. Major, D. T.; Gao, J. J. Am. Chem. Soc. 2006, 128, 16345