A theoretical analysis of rate constants and kinetic isotope effects corresponding to different reactant valleys in lactate dehydrogenase

Journal of the American Chemical Society

Volumn 128, Issue 51, 2006, Pages 16851-16863

  Ferrer, Silvia ^a   Tuñón, Iñaki ^a   Martí, Sergio ^b   Moliner, Vicente ^b   Garcia Viloca, Mireia ^c   González Lafont, Àngels ^c   Lluch, José M ^c  

^a UNIVERSITY OF VALENCIA   (Spain)

^b UNIVERSITAT JAUME I   (Spain)

^c UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYSIS; COMPLEXATION; COMPUTATIONAL METHODS; HYDROGEN; ISOTOPES; RATE CONSTANTS;

ENZYMATIC SYSTEMS; KINETIC ISOTOPE EFFECTS; LACTATE DEHYDROGENASE; THEORETICAL ANALYSIS;

ENZYME KINETICS;

ARGININE; HYDROGEN; LACTATE DEHYDROGENASE; LACTIC ACID; PYRUVIC ACID;

ARTICLE; BINDING KINETICS; CHEMICAL MODIFICATION; CHEMICAL REACTION KINETICS; ENZYME ANALYSIS; ISOTOPE ANALYSIS; MOLECULAR INTERACTION; PROTON TRANSPORT; REACTION ANALYSIS; THEORETICAL MODEL; VALIDATION PROCESS;

CATALYSIS; COMPUTER SIMULATION; KINETICS; L-LACTATE DEHYDROGENASE; LACTIC ACID; MODELS, BIOLOGICAL; MODELS, MOLECULAR; PROTEIN CONFORMATION; PROTONS; PYRUVIC ACID; THERMODYNAMICS; TIME FACTORS; WATER;

EID: 33845960508     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja0653977     Document Type: Article

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