-
1
-
-
0021830154
-
A novel ras-related gene family
-
Madaule P, Axel R. A novel ras-related gene family. Cell 1985;41:31-40.
-
(1985)
Cell
, vol.41
, pp. 31-40
-
-
Madaule, P.1
Axel, R.2
-
2
-
-
27944479854
-
Rho GTPases: biochemistry and biology
-
Jaffe AB, Hall A. Rho GTPases: biochemistry and biology. Annu Rev Cell Dev Biol 2005;21:247-269.
-
(2005)
Annu Rev Cell Dev Biol
, vol.21
, pp. 247-269
-
-
Jaffe, A.B.1
Hall, A.2
-
3
-
-
0026654125
-
The small GTP-binding protein rac regulates growth factor-induced membrane ruffling
-
Ridley AJ, Paterson HF, Johnston CL, Diekmann D, Hall A. The small GTP-binding protein rac regulates growth factor-induced membrane ruffling. Cell 1992;70:401-410.
-
(1992)
Cell
, vol.70
, pp. 401-410
-
-
Ridley, A.J.1
Paterson, H.F.2
Johnston, C.L.3
Diekmann, D.4
Hall, A.5
-
4
-
-
0026778133
-
The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors
-
Ridley AJ, Hall A. The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors. Cell 1992;70:389-399.
-
(1992)
Cell
, vol.70
, pp. 389-399
-
-
Ridley, A.J.1
Hall, A.2
-
5
-
-
0036644975
-
Guanine nucleotide exchange factors for Rho GTPases: turning on the switch
-
Schmidt A, Hall A. Guanine nucleotide exchange factors for Rho GTPases: turning on the switch. Genes Dev 2002;16:1587-1609.
-
(2002)
Genes Dev
, vol.16
, pp. 1587-1609
-
-
Schmidt, A.1
Hall, A.2
-
6
-
-
0037213689
-
Rho GTPase-activating proteins in cell regulation
-
Moon SY, Zheng Y. Rho GTPase-activating proteins in cell regulation. Trends Cell Biol 2003;13:13-22.
-
(2003)
Trends Cell Biol
, vol.13
, pp. 13-22
-
-
Moon, S.Y.1
Zheng, Y.2
-
7
-
-
21744432683
-
GDIs: central regulatory molecules in Rho GTPase activation
-
DerMardirossian C, Bokoch GM. GDIs: central regulatory molecules in Rho GTPase activation. Trends Cell Biol 2005;15:356-363.
-
(2005)
Trends Cell Biol
, vol.15
, pp. 356-363
-
-
DerMardirossian, C.1
Bokoch, G.M.2
-
8
-
-
33846969965
-
Current knowledge of the large RhoGAP family of proteins
-
Tcherkezian J, Lamarche-Vane N. Current knowledge of the large RhoGAP family of proteins. Biol Cell 2007;99:67-86.
-
(2007)
Biol Cell
, vol.99
, pp. 67-86
-
-
Tcherkezian, J.1
Lamarche-Vane, N.2
-
9
-
-
0021825489
-
Isolation of a new human oncogene from a diffuse B-cell lymphoma
-
Eva A, Aaronson SA. Isolation of a new human oncogene from a diffuse B-cell lymphoma. Nature 1985;316:273-275.
-
(1985)
Nature
, vol.316
, pp. 273-275
-
-
Eva, A.1
Aaronson, S.A.2
-
10
-
-
0024829578
-
Multicopy suppression of the cdc24 budding defect in yeast by CDC42 and three newly identified genes including the ras-related gene RSR1
-
Bender A, Pringle JR. Multicopy suppression of the cdc24 budding defect in yeast by CDC42 and three newly identified genes including the ras-related gene RSR1. Proc Natl Acad Sci USA 1989;86:9976-9980.
-
(1989)
Proc Natl Acad Sci USA
, vol.86
, pp. 9976-9980
-
-
Bender, A.1
Pringle, J.R.2
-
11
-
-
0025758833
-
A region of proto-dbl essential for its transforming activity shows sequence similarity to a yeast cell cycle gene, CDC24, and the human breakpoint cluster gene, bcr
-
Ron D, et al. A region of proto-dbl essential for its transforming activity shows sequence similarity to a yeast cell cycle gene, CDC24, and the human breakpoint cluster gene, bcr. New Biol 1991;3:372-379.
-
(1991)
New Biol
, vol.3
, pp. 372-379
-
-
Ron, D.1
-
12
-
-
0026044409
-
Catalysis of guanine nucleotide exchange on the CDC42Hs protein by the dbl oncogene product
-
Hart MJ, Eva A, Evans T, Aaronson SA, Cerione RA. Catalysis of guanine nucleotide exchange on the CDC42Hs protein by the dbl oncogene product. Nature 1991;354:311-314.
-
(1991)
Nature
, vol.354
, pp. 311-314
-
-
Hart, M.J.1
Eva, A.2
Evans, T.3
Aaronson, S.A.4
Cerione, R.A.5
-
13
-
-
0031831780
-
Pleckstrin homology domains: a common fold with diverse functions
-
Rebecchi MJ, Scarlata S. Pleckstrin homology domains: a common fold with diverse functions. Annu Rev Biophys Biomol Struct 1998;27:503-528.
-
(1998)
Annu Rev Biophys Biomol Struct
, vol.27
, pp. 503-528
-
-
Rebecchi, M.J.1
Scarlata, S.2
-
14
-
-
0033635275
-
Structural basis for discrimination of 3-phosphoinositides by pleckstrin homology domains
-
Ferguson KM, et al. Structural basis for discrimination of 3-phosphoinositides by pleckstrin homology domains. Mol Cell 2000;6:373-384.
-
(2000)
Mol Cell
, vol.6
, pp. 373-384
-
-
Ferguson, K.M.1
-
15
-
-
0034663568
-
Signal-dependent membrane targeting by pleckstrin homology (PH) domains
-
Lemmon MA, Ferguson KM. Signal-dependent membrane targeting by pleckstrin homology (PH) domains. Biochem J 2000;350(Pt 1):1-18.
-
(2000)
Biochem J
, vol.350
, Issue.PART 1
, pp. 1-18
-
-
Lemmon, M.A.1
Ferguson, K.M.2
-
16
-
-
0032473948
-
Domains of rasGAP and rhoGAP are related
-
Bax B. Domains of rasGAP and rhoGAP are related. Nature 1998;392:447-448.
-
(1998)
Nature
, vol.392
, pp. 447-448
-
-
Bax, B.1
-
17
-
-
0025873083
-
Bcr encodes a GTPase-activating protein for p21rac
-
Diekmann D, et al. Bcr encodes a GTPase-activating protein for p21rac. Nature 1991;351:400-402.
-
(1991)
Nature
, vol.351
, pp. 400-402
-
-
Diekmann, D.1
-
18
-
-
0037115488
-
Identification of an evolutionarily conserved superfamily of DOCK180-related proteins with guanine nucleotide exchange activity
-
Cote JF, Vuori K. Identification of an evolutionarily conserved superfamily of DOCK180-related proteins with guanine nucleotide exchange activity. J Cell Sci 2002;115:4901-4913.
-
(2002)
J Cell Sci
, vol.115
, pp. 4901-4913
-
-
Cote, J.F.1
Vuori, K.2
-
19
-
-
0036045768
-
Unconventional Rac-GEF activity is mediated through the Dock180-ELMO complex
-
Brugnera E, et al. Unconventional Rac-GEF activity is mediated through the Dock180-ELMO complex. Nat Cell Biol 2002;4:574-582.
-
(2002)
Nat Cell Biol
, vol.4
, pp. 574-582
-
-
Brugnera, E.1
-
20
-
-
0028338545
-
Activation of phosphoinositide 3-kinase activity by Cdc42Hs binding to p85
-
Zheng Y, Bagrodia S, Cerione RA. Activation of phosphoinositide 3-kinase activity by Cdc42Hs binding to p85. J Biol Chem 1994;269:18727-18730.
-
(1994)
J Biol Chem
, vol.269
, pp. 18727-18730
-
-
Zheng, Y.1
Bagrodia, S.2
Cerione, R.A.3
-
21
-
-
0029779004
-
The GTPase-activating protein n-chimaerin cooperates with Rac1 and Cdc42Hs to induce the formation of lamellipodia and filopodia
-
Kozma R, Ahmed S, Best A, Lim L. The GTPase-activating protein n-chimaerin cooperates with Rac1 and Cdc42Hs to induce the formation of lamellipodia and filopodia. Mol Cell Biol 1996;16:5069-5080.
-
(1996)
Mol Cell Biol
, vol.16
, pp. 5069-5080
-
-
Kozma, R.1
Ahmed, S.2
Best, A.3
Lim, L.4
-
22
-
-
84856531511
-
Off the beaten paths: alternative and crosstalk regulation of Rho GTPases
-
Boulter E, Estrach S, Garcia-Mata R, Feral CC. Off the beaten paths: alternative and crosstalk regulation of Rho GTPases. FASEB J 2012;26:469-479.
-
(2012)
FASEB J
, vol.26
, pp. 469-479
-
-
Boulter, E.1
Estrach, S.2
Garcia-Mata, R.3
Feral, C.C.4
-
23
-
-
84862773457
-
Rho GTPase regulation by miRNAs and covalent modifications
-
Liu M, Bi F, Zhou X, Zheng Y. Rho GTPase regulation by miRNAs and covalent modifications. Trends Cell Biol 2012;22:365-373.
-
(2012)
Trends Cell Biol
, vol.22
, pp. 365-373
-
-
Liu, M.1
Bi, F.2
Zhou, X.3
Zheng, Y.4
-
24
-
-
0030040750
-
Protein kinase A phosphorylation of RhoA mediates the morphological and functional effects of cyclic AMP in cytotoxic lymphocytes
-
Lang P, Gesbert F, Delespine-Carmagnat M, Stancou R, Pouchelet M, Bertoglio J. Protein kinase A phosphorylation of RhoA mediates the morphological and functional effects of cyclic AMP in cytotoxic lymphocytes. EMBO J 1996;15:510-519.
-
(1996)
EMBO J
, vol.15
, pp. 510-519
-
-
Lang, P.1
Gesbert, F.2
Delespine-Carmagnat, M.3
Stancou, R.4
Pouchelet, M.5
Bertoglio, J.6
-
25
-
-
0344758986
-
Regulation of cell polarity and protrusion formation by targeting RhoA for degradation
-
Wang HR, et al. Regulation of cell polarity and protrusion formation by targeting RhoA for degradation. Science 2003;302:1775-1779.
-
(2003)
Science
, vol.302
, pp. 1775-1779
-
-
Wang, H.R.1
-
26
-
-
0037069690
-
Rho GTPases in cell biology
-
Etienne-Manneville S, Hall A. Rho GTPases in cell biology. Nature 2002;420:629-635.
-
(2002)
Nature
, vol.420
, pp. 629-635
-
-
Etienne-Manneville, S.1
Hall, A.2
-
27
-
-
0029101360
-
An essential role for Rho, Rac, and Cdc42 GTPases in cell cycle progression through G1
-
Olson MF, Ashworth A, Hall A. An essential role for Rho, Rac, and Cdc42 GTPases in cell cycle progression through G1. Science 1995;269:1270-1272.
-
(1995)
Science
, vol.269
, pp. 1270-1272
-
-
Olson, M.F.1
Ashworth, A.2
Hall, A.3
-
28
-
-
2342432240
-
Cdc42-the centre of polarity
-
Etienne-Manneville S. Cdc42-the centre of polarity. J Cell Sci 2004;117:1291-1300.
-
(2004)
J Cell Sci
, vol.117
, pp. 1291-1300
-
-
Etienne-Manneville, S.1
-
29
-
-
0033520458
-
Integration of Rac-dependent regulation of cyclin D1 transcription through a nuclear factor-kappaB-dependent pathway
-
Joyce D, et al. Integration of Rac-dependent regulation of cyclin D1 transcription through a nuclear factor-kappaB-dependent pathway. J Biol Chem 1999;274:25245-25249.
-
(1999)
J Biol Chem
, vol.274
, pp. 25245-25249
-
-
Joyce, D.1
-
30
-
-
0035736485
-
Timing of cyclin D1 expression within G1 phase is controlled by Rho
-
Welsh CF, Roovers K, Villanueva J, Liu Y, Schwartz MA, Assoian RK. Timing of cyclin D1 expression within G1 phase is controlled by Rho. Nat Cell Biol 2001;3:950-957.
-
(2001)
Nat Cell Biol
, vol.3
, pp. 950-957
-
-
Welsh, C.F.1
Roovers, K.2
Villanueva, J.3
Liu, Y.4
Schwartz, M.A.5
Assoian, R.K.6
-
31
-
-
0029055812
-
The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signaling pathway
-
Coso OA, et al. The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signaling pathway. Cell 1995;81:1137-1146.
-
(1995)
Cell
, vol.81
, pp. 1137-1146
-
-
Coso, O.A.1
-
32
-
-
0038737042
-
Actin dynamics control SRF activity by regulation of its coactivator MAL
-
Miralles F, Posern G, Zaromytidou AI, Treisman R. Actin dynamics control SRF activity by regulation of its coactivator MAL. Cell 2003;113:329-342.
-
(2003)
Cell
, vol.113
, pp. 329-342
-
-
Miralles, F.1
Posern, G.2
Zaromytidou, A.I.3
Treisman, R.4
-
33
-
-
0028169005
-
Interaction of Rac with p67phox and regulation of phagocytic NADPH oxidase activity
-
Diekmann D, Abo A, Johnston C, Segal AW, Hall A. Interaction of Rac with p67phox and regulation of phagocytic NADPH oxidase activity. Science 1994;265:531-533.
-
(1994)
Science
, vol.265
, pp. 531-533
-
-
Diekmann, D.1
Abo, A.2
Johnston, C.3
Segal, A.W.4
Hall, A.5
-
34
-
-
1442307630
-
Molecular mechanism for activation of superoxide-producing NADPH oxidases
-
Takeya R, Sumimoto H. Molecular mechanism for activation of superoxide-producing NADPH oxidases. Mol Cells 2003;16:271-277.
-
(2003)
Mol Cells
, vol.16
, pp. 271-277
-
-
Takeya, R.1
Sumimoto, H.2
-
35
-
-
0036468982
-
The oncoprotein 18/stathmin family of microtubule destabilizers
-
Cassimeris L. The oncoprotein 18/stathmin family of microtubule destabilizers. Curr Opin Cell Biol 2002;14:18-24.
-
(2002)
Curr Opin Cell Biol
, vol.14
, pp. 18-24
-
-
Cassimeris, L.1
-
36
-
-
0029894664
-
Identification of a novel human Rho protein with unusual properties: GTPase deficiency and in vivo farnesylation
-
Foster R, Hu KQ, Lu Y, Nolan KM, Thissen J, Settleman J. Identification of a novel human Rho protein with unusual properties: GTPase deficiency and in vivo farnesylation. Mol Cell Biol 1996;16:2689-2699.
-
(1996)
Mol Cell Biol
, vol.16
, pp. 2689-2699
-
-
Foster, R.1
Hu, K.Q.2
Lu, Y.3
Nolan, K.M.4
Thissen, J.5
Settleman, J.6
-
37
-
-
0034461613
-
Induced expression of Rnd3 is associated with transformation of polarized epithelial cells by the Raf-MEK-extracellular signal-regulated kinase pathway
-
Hansen SH, et al. Induced expression of Rnd3 is associated with transformation of polarized epithelial cells by the Raf-MEK-extracellular signal-regulated kinase pathway. Mol Cell Biol 2000;20:9364-9375.
-
(2000)
Mol Cell Biol
, vol.20
, pp. 9364-9375
-
-
Hansen, S.H.1
-
38
-
-
0038655599
-
RhoE binds to ROCK I and inhibits downstream signaling
-
Riento K, Guasch RM, Garg R, Jin B, Ridley AJ. RhoE binds to ROCK I and inhibits downstream signaling. Mol Cell Biol 2003;23:4219-4229.
-
(2003)
Mol Cell Biol
, vol.23
, pp. 4219-4229
-
-
Riento, K.1
Guasch, R.M.2
Garg, R.3
Jin, B.4
Ridley, A.J.5
-
39
-
-
0037145522
-
Genomic organization and expression profile of the small GTPases of the RhoBTB family in human and mouse
-
Ramos S, Khademi F, Somesh BP, Rivero F. Genomic organization and expression profile of the small GTPases of the RhoBTB family in human and mouse. Gene 2002;298:147-157.
-
(2002)
Gene
, vol.298
, pp. 147-157
-
-
Ramos, S.1
Khademi, F.2
Somesh, B.P.3
Rivero, F.4
-
40
-
-
0024449589
-
The mammalian G protein rhoC is ADP-ribosylated by Clostridium botulinum exoenzyme C3 and affects actin microfilaments in Vero cells
-
Chardin P, Boquet P, Madaule P, Popoff MR, Rubin EJ, Gill DM. The mammalian G protein rhoC is ADP-ribosylated by Clostridium botulinum exoenzyme C3 and affects actin microfilaments in Vero cells. EMBO J 1989;8:1087-1092.
-
(1989)
EMBO J
, vol.8
, pp. 1087-1092
-
-
Chardin, P.1
Boquet, P.2
Madaule, P.3
Popoff, M.R.4
Rubin, E.J.5
Gill, D.M.6
-
41
-
-
17844406602
-
Bacterial cytotoxins: targeting eukaryotic switches
-
Aktories K, Barbieri JT. Bacterial cytotoxins: targeting eukaryotic switches. Nat Rev Microbiol 2005;3:397-410.
-
(2005)
Nat Rev Microbiol
, vol.3
, pp. 397-410
-
-
Aktories, K.1
Barbieri, J.T.2
-
42
-
-
0025195876
-
Microinjection of recombinant p21rho induces rapid changes in cell morphology
-
Paterson HF, Self AJ, Garrett MD, Just I, Aktories K, Hall A. Microinjection of recombinant p21rho induces rapid changes in cell morphology. J Cell Biol 1990;111:1001-1007.
-
(1990)
J Cell Biol
, vol.111
, pp. 1001-1007
-
-
Paterson, H.F.1
Self, A.J.2
Garrett, M.D.3
Just, I.4
Aktories, K.5
Hall, A.6
-
43
-
-
0028986034
-
The Ras-related protein Cdc42Hs and bradykinin promote formation of peripheral actin microspikes and filopodia in Swiss 3T3 fibroblasts
-
Kozma R, Ahmed S, Best A, Lim L. The Ras-related protein Cdc42Hs and bradykinin promote formation of peripheral actin microspikes and filopodia in Swiss 3T3 fibroblasts. Mol Cell Biol 1995;15:1942-1952.
-
(1995)
Mol Cell Biol
, vol.15
, pp. 1942-1952
-
-
Kozma, R.1
Ahmed, S.2
Best, A.3
Lim, L.4
-
44
-
-
0029166671
-
Rho, rac and cdc42 GTPases: regulators of actin structures, cell adhesion and motility
-
Nobes CD, Hall A. Rho, rac and cdc42 GTPases: regulators of actin structures, cell adhesion and motility. Biochem Soc Trans 1995;23:456-459.
-
(1995)
Biochem Soc Trans
, vol.23
, pp. 456-459
-
-
Nobes, C.D.1
Hall, A.2
-
45
-
-
0842281652
-
Rho and Rac take center stage
-
Burridge K, Wennerberg K. Rho and Rac take center stage. Cell 2004;116:167-179.
-
(2004)
Cell
, vol.116
, pp. 167-179
-
-
Burridge, K.1
Wennerberg, K.2
-
46
-
-
9444242736
-
Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho-kinase)
-
Kimura K, et al. Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho-kinase). Science 1996;273:245-248.
-
(1996)
Science
, vol.273
, pp. 245-248
-
-
Kimura, K.1
-
47
-
-
0029995797
-
Rho-stimulated contractility drives the formation of stress fibers and focal adhesions
-
Chrzanowska-Wodnicka M, Burridge K. Rho-stimulated contractility drives the formation of stress fibers and focal adhesions. J Cell Biol 1996;133:1403-1415.
-
(1996)
J Cell Biol
, vol.133
, pp. 1403-1415
-
-
Chrzanowska-Wodnicka, M.1
Burridge, K.2
-
48
-
-
0030035043
-
Identification of a putative target for Rho as the serine-threonine kinase protein kinase N
-
Amano M, et al. Identification of a putative target for Rho as the serine-threonine kinase protein kinase N. Science 1996;271:648-650.
-
(1996)
Science
, vol.271
, pp. 648-650
-
-
Amano, M.1
-
49
-
-
13344285358
-
Protein kinase N (PKN) and PKN-related protein rhophilin as targets of small GTPase Rho
-
Watanabe G, et al. Protein kinase N (PKN) and PKN-related protein rhophilin as targets of small GTPase Rho. Science 1996;271:645-648.
-
(1996)
Science
, vol.271
, pp. 645-648
-
-
Watanabe, G.1
-
50
-
-
0034602959
-
Rho-associated kinase ROCK activates LIM-kinase 1 by phosphorylation at threonine 508 within the activation loop
-
Ohashi K, Nagata K, Maekawa M, Ishizaki T, Narumiya S, Mizuno K. Rho-associated kinase ROCK activates LIM-kinase 1 by phosphorylation at threonine 508 within the activation loop. J Biol Chem 2000;275:3577-3582.
-
(2000)
J Biol Chem
, vol.275
, pp. 3577-3582
-
-
Ohashi, K.1
Nagata, K.2
Maekawa, M.3
Ishizaki, T.4
Narumiya, S.5
Mizuno, K.6
-
51
-
-
0033529620
-
Signaling from Rho to the actin cytoskeleton through protein kinases ROCK and LIM-kinase
-
Maekawa M, et al. Signaling from Rho to the actin cytoskeleton through protein kinases ROCK and LIM-kinase. Science 1999;285:895-898.
-
(1999)
Science
, vol.285
, pp. 895-898
-
-
Maekawa, M.1
-
52
-
-
0032581530
-
Role of citron kinase as a target of the small GTPase Rho in cytokinesis
-
Madaule P, et al. Role of citron kinase as a target of the small GTPase Rho in cytokinesis. Nature 1998;394:491-494.
-
(1998)
Nature
, vol.394
, pp. 491-494
-
-
Madaule, P.1
-
53
-
-
0030911424
-
p140mDia, a mammalian homolog of Drosophila diaphanous, is a target protein for Rho small GTPase and is a ligand for profilin
-
Watanabe N, et al. p140mDia, a mammalian homolog of Drosophila diaphanous, is a target protein for Rho small GTPase and is a ligand for profilin. EMBO J 1997;16:3044-3056.
-
(1997)
EMBO J
, vol.16
, pp. 3044-3056
-
-
Watanabe, N.1
-
54
-
-
60749122102
-
Actin nucleation and elongation factors: mechanisms and interplay
-
Chesarone MA, Goode BL. Actin nucleation and elongation factors: mechanisms and interplay. Curr Opin Cell Biol 2009;21:28-37.
-
(2009)
Curr Opin Cell Biol
, vol.21
, pp. 28-37
-
-
Chesarone, M.A.1
Goode, B.L.2
-
55
-
-
72949110575
-
Unleashing formins to remodel the actin and microtubule cytoskeletons
-
Chesarone MA, DuPage AG, Goode BL. Unleashing formins to remodel the actin and microtubule cytoskeletons. Nat Rev Mol Cell Biol 2010;11:62-74.
-
(2010)
Nat Rev Mol Cell Biol
, vol.11
, pp. 62-74
-
-
Chesarone, M.A.1
DuPage, A.G.2
Goode, B.L.3
-
56
-
-
36348984486
-
High-resolution structural analysis of mammalian profilin 2a complex formation with two physiological ligands: the formin homology 1 domain of mDia1 and the proline-rich domain of VASP
-
Kursula P, et al. High-resolution structural analysis of mammalian profilin 2a complex formation with two physiological ligands: the formin homology 1 domain of mDia1 and the proline-rich domain of VASP. J Mol Biol 2008;375:270-290.
-
(2008)
J Mol Biol
, vol.375
, pp. 270-290
-
-
Kursula, P.1
-
57
-
-
34247644614
-
Regulation of actin filament assembly by Arp2/3 complex and formins
-
Pollard TD. Regulation of actin filament assembly by Arp2/3 complex and formins. Annu Rev Biophys Biomol Struct 2007;36:451-477.
-
(2007)
Annu Rev Biophys Biomol Struct
, vol.36
, pp. 451-477
-
-
Pollard, T.D.1
-
58
-
-
0033574722
-
The interaction between N-WASP and the Arp2/3 complex links Cdc42-dependent signals to actin assembly
-
Rohatgi R, et al. The interaction between N-WASP and the Arp2/3 complex links Cdc42-dependent signals to actin assembly. Cell 1999;97:221-231.
-
(1999)
Cell
, vol.97
, pp. 221-231
-
-
Rohatgi, R.1
-
59
-
-
0031952518
-
Induction of filopodium formation by a WASP-related actin-depolymerizing protein N-WASP
-
Miki H, Sasaki T, Takai Y, Takenawa T. Induction of filopodium formation by a WASP-related actin-depolymerizing protein N-WASP. Nature 1998;391:93-96.
-
(1998)
Nature
, vol.391
, pp. 93-96
-
-
Miki, H.1
Sasaki, T.2
Takai, Y.3
Takenawa, T.4
-
60
-
-
0032585538
-
Scar1 and the related Wiskott-Aldrich syndrome protein, WASP, regulate the actin cytoskeleton through the Arp2/3 complex
-
Machesky LM, Insall RH. Scar1 and the related Wiskott-Aldrich syndrome protein, WASP, regulate the actin cytoskeleton through the Arp2/3 complex. Curr Biol 1998;8:1347-1356.
-
(1998)
Curr Biol
, vol.8
, pp. 1347-1356
-
-
Machesky, L.M.1
Insall, R.H.2
-
61
-
-
0037102301
-
Mechanism of regulation of WAVE1-induced actin nucleation by Rac1 and Nck
-
Eden S, Rohatgi R, Podtelejnikov AV, Mann M, Kirschner MW. Mechanism of regulation of WAVE1-induced actin nucleation by Rac1 and Nck. Nature 2002;418:790-793.
-
(2002)
Nature
, vol.418
, pp. 790-793
-
-
Eden, S.1
Rohatgi, R.2
Podtelejnikov, A.V.3
Mann, M.4
Kirschner, M.W.5
-
62
-
-
0036711657
-
Filamin is essential in actin cytoskeletal assembly mediated by p21-activated kinase 1
-
Vadlamudi RK, et al. Filamin is essential in actin cytoskeletal assembly mediated by p21-activated kinase 1. Nat Cell Biol 2002;4:681-690.
-
(2002)
Nat Cell Biol
, vol.4
, pp. 681-690
-
-
Vadlamudi, R.K.1
-
63
-
-
0030820404
-
Signal transduction pathways involving the small G proteins rac and Cdc42 and phosphoinositide kinases
-
Carpenter CL, Tolias KF, Couvillon AC, Hartwig JH. Signal transduction pathways involving the small G proteins rac and Cdc42 and phosphoinositide kinases. Adv Enzyme Regul 1997;37:377-390.
-
(1997)
Adv Enzyme Regul
, vol.37
, pp. 377-390
-
-
Carpenter, C.L.1
Tolias, K.F.2
Couvillon, A.C.3
Hartwig, J.H.4
-
64
-
-
0038311944
-
Phosphoinositide regulation of the actin cytoskeleton
-
Yin HL, Janmey PA. Phosphoinositide regulation of the actin cytoskeleton. Annu Rev Physiol 2003;65:761-789.
-
(2003)
Annu Rev Physiol
, vol.65
, pp. 761-789
-
-
Yin, H.L.1
Janmey, P.A.2
-
65
-
-
11844280881
-
The Cool-2/alpha-Pix protein mediates a Cdc42-Rac signaling cascade
-
Baird D, Feng Q, Cerione RA. The Cool-2/alpha-Pix protein mediates a Cdc42-Rac signaling cascade. Curr Biol 2005;15:1-10.
-
(2005)
Curr Biol
, vol.15
, pp. 1-10
-
-
Baird, D.1
Feng, Q.2
Cerione, R.A.3
-
67
-
-
33746658154
-
FilGAP, a Rho- and ROCK-regulated GAP for Rac binds filamin A to control actin remodelling
-
Ohta Y, Hartwig JH, Stossel TP. FilGAP, a Rho- and ROCK-regulated GAP for Rac binds filamin A to control actin remodelling. Nat Cell Biol 2006;8:803-814.
-
(2006)
Nat Cell Biol
, vol.8
, pp. 803-814
-
-
Ohta, Y.1
Hartwig, J.H.2
Stossel, T.P.3
-
68
-
-
33646197411
-
Spatiotemporal dynamics of RhoA activity in migrating cells
-
Pertz O, Hodgson L, Klemke RL, Hahn KM. Spatiotemporal dynamics of RhoA activity in migrating cells. Nature 2006;440:1069-1072.
-
(2006)
Nature
, vol.440
, pp. 1069-1072
-
-
Pertz, O.1
Hodgson, L.2
Klemke, R.L.3
Hahn, K.M.4
-
70
-
-
0033174147
-
Rac regulates phosphorylation of the myosin-II heavy chain, actinomyosin disassembly and cell spreading
-
van Leeuwen FN, van Delft S, Kain HE, van der Kammen RA, Collard JG. Rac regulates phosphorylation of the myosin-II heavy chain, actinomyosin disassembly and cell spreading. Nat Cell Biol 1999;1:242-248.
-
(1999)
Nat Cell Biol
, vol.1
, pp. 242-248
-
-
van Leeuwen, F.N.1
van Delft, S.2
Kain, H.E.3
van der Kammen, R.A.4
Collard, J.G.5
-
71
-
-
0035910554
-
Rac/Cdc42 and p65PAK regulate the microtubule-destabilizing protein stathmin through phosphorylation at serine 16
-
Daub H, Gevaert K, Vandekerckhove J, Sobel A, Hall A. Rac/Cdc42 and p65PAK regulate the microtubule-destabilizing protein stathmin through phosphorylation at serine 16. J Biol Chem 2001;276:1677-1680.
-
(2001)
J Biol Chem
, vol.276
, pp. 1677-1680
-
-
Daub, H.1
Gevaert, K.2
Vandekerckhove, J.3
Sobel, A.4
Hall, A.5
-
72
-
-
33748577718
-
The Rac activator DOCK7 regulates neuronal polarity through local phosphorylation of stathmin/Op18
-
Watabe-Uchida M, John KA, Janas JA, Newey SE, Van Aelst L. The Rac activator DOCK7 regulates neuronal polarity through local phosphorylation of stathmin/Op18. Neuron 2006;51:727-739.
-
(2006)
Neuron
, vol.51
, pp. 727-739
-
-
Watabe-Uchida, M.1
John, K.A.2
Janas, J.A.3
Newey, S.E.4
Van Aelst, L.5
-
73
-
-
18444369936
-
Rac1 and Cdc42 capture microtubules through IQGAP1 and CLIP-170
-
Fukata M, et al. Rac1 and Cdc42 capture microtubules through IQGAP1 and CLIP-170. Cell 2002;109:873-885.
-
(2002)
Cell
, vol.109
, pp. 873-885
-
-
Fukata, M.1
-
75
-
-
10644281068
-
Interaction with IQGAP1 links APC to Rac1, Cdc42, and actin filaments during cell polarization and migration
-
Watanabe T, et al. Interaction with IQGAP1 links APC to Rac1, Cdc42, and actin filaments during cell polarization and migration. Dev Cell 2004;7:871-883.
-
(2004)
Dev Cell
, vol.7
, pp. 871-883
-
-
Watanabe, T.1
-
76
-
-
77649215060
-
Rho GTPases in hematopoiesis and hemopathies
-
Mulloy JC, Cancelas JA, Filippi MD, Kalfa TA, Guo F, Zheng Y. Rho GTPases in hematopoiesis and hemopathies. Blood 2010;115:936-947.
-
(2010)
Blood
, vol.115
, pp. 936-947
-
-
Mulloy, J.C.1
Cancelas, J.A.2
Filippi, M.D.3
Kalfa, T.A.4
Guo, F.5
Zheng, Y.6
-
77
-
-
0028259050
-
ADP-ribosylation of the GTP-binding protein Rho by Clostridium limosum exoenzyme affects basal, but not N-formyl-peptide-stimulated, actin polymerization in human myeloid leukaemic (HL60) cells
-
Koch G, Norgauer J, Aktories K. ADP-ribosylation of the GTP-binding protein Rho by Clostridium limosum exoenzyme affects basal, but not N-formyl-peptide-stimulated, actin polymerization in human myeloid leukaemic (HL60) cells. Biochem J 1994;299(Pt 3):775-779.
-
(1994)
Biochem J
, vol.299
, Issue.PART 3
, pp. 775-779
-
-
Koch, G.1
Norgauer, J.2
Aktories, K.3
-
78
-
-
0029089841
-
ADP-ribosylation of Rho enhances actin polymerization-coupled shape oscillations in human neutrophils
-
Ehrengruber MU, Boquet P, Coates TD, Deranleau DA. ADP-ribosylation of Rho enhances actin polymerization-coupled shape oscillations in human neutrophils. FEBS Lett 1995;372:161-164.
-
(1995)
FEBS Lett
, vol.372
, pp. 161-164
-
-
Ehrengruber, M.U.1
Boquet, P.2
Coates, T.D.3
Deranleau, D.A.4
-
79
-
-
0025833804
-
ADP-ribosylation of a small size GTP-binding protein in bovine neutrophils by the C3 exoenzyme of Clostridium botulinum and effect on the cell motility
-
Stasia MJ, Jouan A, Bourmeyster N, Boquet P, Vignais PV. ADP-ribosylation of a small size GTP-binding protein in bovine neutrophils by the C3 exoenzyme of Clostridium botulinum and effect on the cell motility. Biochem Biophys Res Commun 1991;180:615-622.
-
(1991)
Biochem Biophys Res Commun
, vol.180
, pp. 615-622
-
-
Stasia, M.J.1
Jouan, A.2
Bourmeyster, N.3
Boquet, P.4
Vignais, P.V.5
-
80
-
-
0030940218
-
Rho, Rac and Cdc42 regulate actin organization and cell adhesion in macrophages
-
Allen WE, Jones GE, Pollard JW, Ridley AJ. Rho, Rac and Cdc42 regulate actin organization and cell adhesion in macrophages. J Cell Sci 1997;110(Pt 6):707-720.
-
(1997)
J Cell Sci
, vol.110
, Issue.PART 6
, pp. 707-720
-
-
Allen, W.E.1
Jones, G.E.2
Pollard, J.W.3
Ridley, A.J.4
-
81
-
-
0031794359
-
The Rho GTPases in macrophage motility and chemotaxis
-
Jones GE, Allen WE, Ridley AJ. The Rho GTPases in macrophage motility and chemotaxis. Cell Adhes Commun 1998;6:237-245.
-
(1998)
Cell Adhes Commun
, vol.6
, pp. 237-245
-
-
Jones, G.E.1
Allen, W.E.2
Ridley, A.J.3
-
83
-
-
0030684003
-
Requirements for both Rac1 and Cdc42 in membrane ruffling and phagocytosis in leukocytes
-
Cox D, Chang P, Zhang Q, Reddy PG, Bokoch GM, Greenberg S. Requirements for both Rac1 and Cdc42 in membrane ruffling and phagocytosis in leukocytes. J Exp Med 1997;186:1487-1494.
-
(1997)
J Exp Med
, vol.186
, pp. 1487-1494
-
-
Cox, D.1
Chang, P.2
Zhang, Q.3
Reddy, P.G.4
Bokoch, G.M.5
Greenberg, S.6
-
84
-
-
0025944684
-
Activation of the NADPH oxidase involves the small GTP-binding protein p21rac1
-
Abo A, Pick E, Hall A, Totty N, Teahan CG, Segal AW. Activation of the NADPH oxidase involves the small GTP-binding protein p21rac1. Nature 1991;353:668-670.
-
(1991)
Nature
, vol.353
, pp. 668-670
-
-
Abo, A.1
Pick, E.2
Hall, A.3
Totty, N.4
Teahan, C.G.5
Segal, A.W.6
-
85
-
-
0026335622
-
Regulation of phagocyte oxygen radical production by the GTP-binding protein Rac 2
-
Knaus UG, Heyworth PG, Evans T, Curnutte JT, Bokoch GM. Regulation of phagocyte oxygen radical production by the GTP-binding protein Rac 2. Science 1991;254:1512-1515.
-
(1991)
Science
, vol.254
, pp. 1512-1515
-
-
Knaus, U.G.1
Heyworth, P.G.2
Evans, T.3
Curnutte, J.T.4
Bokoch, G.M.5
-
86
-
-
0030029804
-
The Rac target NADPH oxidase p67phox interacts preferentially with Rac2 rather than Rac1
-
Dorseuil O, Reibel L, Bokoch GM, Camonis J, Gacon G. The Rac target NADPH oxidase p67phox interacts preferentially with Rac2 rather than Rac1. J Biol Chem 1996;271:83-88.
-
(1996)
J Biol Chem
, vol.271
, pp. 83-88
-
-
Dorseuil, O.1
Reibel, L.2
Bokoch, G.M.3
Camonis, J.4
Gacon, G.5
-
87
-
-
0025370728
-
A member of the ras gene superfamily is expressed specifically in T, B and myeloid hemopoietic cells
-
Shirsat NV, Pignolo RJ, Kreider BL, Rovera G. A member of the ras gene superfamily is expressed specifically in T, B and myeloid hemopoietic cells. Oncogene 1990;5:769-772.
-
(1990)
Oncogene
, vol.5
, pp. 769-772
-
-
Shirsat, N.V.1
Pignolo, R.J.2
Kreider, B.L.3
Rovera, G.4
-
88
-
-
0025754114
-
The murine rac1 gene: cDNA cloning, tissue distribution and regulated expression of rac1 mRNA by disassembly of actin microfilaments
-
Moll J, Sansig G, Fattori E, van der Putten H. The murine rac1 gene: cDNA cloning, tissue distribution and regulated expression of rac1 mRNA by disassembly of actin microfilaments. Oncogene 1991;6:863-866.
-
(1991)
Oncogene
, vol.6
, pp. 863-866
-
-
Moll, J.1
Sansig, G.2
Fattori, E.3
van der Putten, H.4
-
89
-
-
0024425981
-
rac, a novel ras-related family of proteins that are botulinum toxin substrates
-
Didsbury J, Weber RF, Bokoch GM, Evans T, Snyderman R. rac, a novel ras-related family of proteins that are botulinum toxin substrates. J Biol Chem 1989;264:16378-16382.
-
(1989)
J Biol Chem
, vol.264
, pp. 16378-16382
-
-
Didsbury, J.1
Weber, R.F.2
Bokoch, G.M.3
Evans, T.4
Snyderman, R.5
-
90
-
-
0030824832
-
Characterization of RAC3, a novel member of the Rho family
-
Haataja L, Groffen J, Heisterkamp N. Characterization of RAC3, a novel member of the Rho family. J Biol Chem 1997;272:20384-20388.
-
(1997)
J Biol Chem
, vol.272
, pp. 20384-20388
-
-
Haataja, L.1
Groffen, J.2
Heisterkamp, N.3
-
91
-
-
0033082165
-
Deficiency of the hematopoietic cell-specific Rho family GTPase Rac2 is characterized by abnormalities in neutrophil function and host defense
-
Roberts AW, et al. Deficiency of the hematopoietic cell-specific Rho family GTPase Rac2 is characterized by abnormalities in neutrophil function and host defense. Immunity 1999;10:183-196.
-
(1999)
Immunity
, vol.10
, pp. 183-196
-
-
Roberts, A.W.1
-
92
-
-
0033678937
-
Rac2 stimulates Akt activation affecting BAD/Bcl-XL expression while mediating survival and actin function in primary mast cells
-
Yang FC, et al. Rac2 stimulates Akt activation affecting BAD/Bcl-XL expression while mediating survival and actin function in primary mast cells. Immunity 2000;12:557-568.
-
(2000)
Immunity
, vol.12
, pp. 557-568
-
-
Yang, F.C.1
-
93
-
-
0034705628
-
Role of the guanosine triphosphatase Rac2 in T helper 1 cell differentiation
-
Li B, et al. Role of the guanosine triphosphatase Rac2 in T helper 1 cell differentiation. Science 2000;288:2219-2222.
-
(2000)
Science
, vol.288
, pp. 2219-2222
-
-
Li, B.1
-
94
-
-
0014744817
-
Ontogeny of the haemopoietic system: yolk sac origin of in vivo and in vitro colony forming cells in the developing mouse embryo
-
Moore MA, Metcalf D. Ontogeny of the haemopoietic system: yolk sac origin of in vivo and in vitro colony forming cells in the developing mouse embryo. Br J Haematol 1970;18:279-296.
-
(1970)
Br J Haematol
, vol.18
, pp. 279-296
-
-
Moore, M.A.1
Metcalf, D.2
-
95
-
-
0019787255
-
Diffuse intraembryonic hemopoiesis in normal and chimeric avian development
-
Dieterlen-Lievre F, Martin C. Diffuse intraembryonic hemopoiesis in normal and chimeric avian development. Dev Biol 1981;88:180-191.
-
(1981)
Dev Biol
, vol.88
, pp. 180-191
-
-
Dieterlen-Lievre, F.1
Martin, C.2
-
96
-
-
0028467947
-
Development of hematopoietic stem cell activity in the mouse embryo
-
Muller AM, Medvinsky A, Strouboulis J, Grosveld F, Dzierzak E. Development of hematopoietic stem cell activity in the mouse embryo. Immunity 1994;1:291-301.
-
(1994)
Immunity
, vol.1
, pp. 291-301
-
-
Muller, A.M.1
Medvinsky, A.2
Strouboulis, J.3
Grosveld, F.4
Dzierzak, E.5
-
97
-
-
0030946401
-
Engraftment of embryonic hematopoietic cells in conditioned newborn recipients
-
Yoder MC, Hiatt K. Engraftment of embryonic hematopoietic cells in conditioned newborn recipients. Blood 1997;89:2176-2183.
-
(1997)
Blood
, vol.89
, pp. 2176-2183
-
-
Yoder, M.C.1
Hiatt, K.2
-
98
-
-
0036848557
-
Quantitative developmental anatomy of definitive haematopoietic stem cells/long-term repopulating units (HSC/RUs): role of the aorta-gonad-mesonephros (AGM) region and the yolk sac in colonisation of the mouse embryonic liver
-
Kumaravelu P, et al. Quantitative developmental anatomy of definitive haematopoietic stem cells/long-term repopulating units (HSC/RUs): role of the aorta-gonad-mesonephros (AGM) region and the yolk sac in colonisation of the mouse embryonic liver. Development 2002;129:4891-4899.
-
(2002)
Development
, vol.129
, pp. 4891-4899
-
-
Kumaravelu, P.1
-
99
-
-
33750439078
-
The journey of developing hematopoietic stem cells
-
Mikkola HK, Orkin SH. The journey of developing hematopoietic stem cells. Development 2006;133:3733-3744.
-
(2006)
Development
, vol.133
, pp. 3733-3744
-
-
Mikkola, H.K.1
Orkin, S.H.2
-
100
-
-
0017834345
-
Endosteal marrow: a rich source of hematopoietic stem cells
-
Gong JK. Endosteal marrow: a rich source of hematopoietic stem cells. Science 1978;199:1443-1445.
-
(1978)
Science
, vol.199
, pp. 1443-1445
-
-
Gong, J.K.1
-
101
-
-
33645103515
-
The hematopoietic stem cell in its place
-
Adams GB, Scadden DT. The hematopoietic stem cell in its place. Nat Immunol 2006;7:333-337.
-
(2006)
Nat Immunol
, vol.7
, pp. 333-337
-
-
Adams, G.B.1
Scadden, D.T.2
-
102
-
-
28444486367
-
Stem cell niche: structure and function
-
Li L, Xie T. Stem cell niche: structure and function. Annu Rev Cell Dev Biol 2005;21:605-631.
-
(2005)
Annu Rev Cell Dev Biol
, vol.21
, pp. 605-631
-
-
Li, L.1
Xie, T.2
-
103
-
-
39149144034
-
Stem cells and niches: mechanisms that promote stem cell maintenance throughout life
-
Morrison SJ, Spradling AC. Stem cells and niches: mechanisms that promote stem cell maintenance throughout life. Cell 2008;132:598-611.
-
(2008)
Cell
, vol.132
, pp. 598-611
-
-
Morrison, S.J.1
Spradling, A.C.2
-
104
-
-
33845907908
-
Leukaemia: niche retreats for stem cells
-
Williams DA, Cancelas JA. Leukaemia: niche retreats for stem cells. Nature 2006;444:827-828.
-
(2006)
Nature
, vol.444
, pp. 827-828
-
-
Williams, D.A.1
Cancelas, J.A.2
-
105
-
-
0037355362
-
The whys and hows of hematopoietic progenitor and stem cell mobilization
-
Kessinger A, Sharp JG. The whys and hows of hematopoietic progenitor and stem cell mobilization. Bone Marrow Transplant 2003;31:319-329.
-
(2003)
Bone Marrow Transplant
, vol.31
, pp. 319-329
-
-
Kessinger, A.1
Sharp, J.G.2
-
106
-
-
0028149341
-
Circulating stem cell collection in lymphoma and myeloma after mobilization with cyclophosphamide and granulocyte colony-stimulating factor for autologous transplantation
-
Cancelas JA, et al. Circulating stem cell collection in lymphoma and myeloma after mobilization with cyclophosphamide and granulocyte colony-stimulating factor for autologous transplantation. Vox Sang 1994;67:362-367.
-
(1994)
Vox Sang
, vol.67
, pp. 362-367
-
-
Cancelas, J.A.1
-
107
-
-
0027171934
-
Recombinant rat stem cell factor synergizes with recombinant human granulocyte colony-stimulating factor in vivo in mice to mobilize peripheral blood progenitor cells that have enhanced repopulating potential
-
Briddell RA, Hartley CA, Smith KA, McNiece IK. Recombinant rat stem cell factor synergizes with recombinant human granulocyte colony-stimulating factor in vivo in mice to mobilize peripheral blood progenitor cells that have enhanced repopulating potential. Blood 1993;82:1720-1723.
-
(1993)
Blood
, vol.82
, pp. 1720-1723
-
-
Briddell, R.A.1
Hartley, C.A.2
Smith, K.A.3
McNiece, I.K.4
-
108
-
-
1842509856
-
Rapid mobilization of CD34+ cells following administration of the CXCR4 antagonist AMD3100 to patients with multiple myeloma and non-Hodgkin's lymphoma
-
Devine SM, et al. Rapid mobilization of CD34+ cells following administration of the CXCR4 antagonist AMD3100 to patients with multiple myeloma and non-Hodgkin's lymphoma. J Clin Oncol 2004;22:1095-1102.
-
(2004)
J Clin Oncol
, vol.22
, pp. 1095-1102
-
-
Devine, S.M.1
-
109
-
-
77957762029
-
Pharmacological inhibition of EGFR signaling enhances G-CSF-induced hematopoietic stem cell mobilization
-
Ryan MA, et al. Pharmacological inhibition of EGFR signaling enhances G-CSF-induced hematopoietic stem cell mobilization. Nat Med 2010;16:1141-1146.
-
(2010)
Nat Med
, vol.16
, pp. 1141-1146
-
-
Ryan, M.A.1
-
110
-
-
77955646193
-
Mesenchymal and haematopoietic stem cells form a unique bone marrow niche
-
Mendez-Ferrer S, et al. Mesenchymal and haematopoietic stem cells form a unique bone marrow niche. Nature 2010;466:829-834.
-
(2010)
Nature
, vol.466
, pp. 829-834
-
-
Mendez-Ferrer, S.1
-
111
-
-
0032698747
-
The chemokine SDF-1 stimulates integrin-mediated arrest of CD34(+) cells on vascular endothelium under shear flow
-
Peled A, et al. The chemokine SDF-1 stimulates integrin-mediated arrest of CD34(+) cells on vascular endothelium under shear flow. J Clin Invest 1999;104:1199-1211.
-
(1999)
J Clin Invest
, vol.104
, pp. 1199-1211
-
-
Peled, A.1
-
112
-
-
0033524834
-
Dependence of human stem cell engraftment and repopulation of NOD/SCID mice on CXCR4
-
Peled A, et al. Dependence of human stem cell engraftment and repopulation of NOD/SCID mice on CXCR4. Science 1999;283:845-848.
-
(1999)
Science
, vol.283
, pp. 845-848
-
-
Peled, A.1
-
113
-
-
0034210221
-
The chemokine SDF-1 activates the integrins LFA-1, VLA-4, and VLA-5 on immature human CD34(+) cells: role in transendothelial/stromal migration and engraftment of NOD/SCID mice
-
Peled A, et al. The chemokine SDF-1 activates the integrins LFA-1, VLA-4, and VLA-5 on immature human CD34(+) cells: role in transendothelial/stromal migration and engraftment of NOD/SCID mice. Blood 2000;95:3289-3296.
-
(2000)
Blood
, vol.95
, pp. 3289-3296
-
-
Peled, A.1
-
114
-
-
0344235135
-
Membrane-bound stem cell factor is a key regulator in the initial lodgment of stem cells within the endosteal marrow region
-
Driessen RL, Johnston HM, Nilsson SK. Membrane-bound stem cell factor is a key regulator in the initial lodgment of stem cells within the endosteal marrow region. Exp Hematol 2003;31:1284-1291.
-
(2003)
Exp Hematol
, vol.31
, pp. 1284-1291
-
-
Driessen, R.L.1
Johnston, H.M.2
Nilsson, S.K.3
-
115
-
-
0028917884
-
Membrane-bound Steel factor induces more persistent tyrosine kinase activation and longer life span of c-kit gene-encoded protein than its soluble form
-
Miyazawa K, Williams DA, Gotoh A, Nishimaki J, Broxmeyer HE, Toyama K. Membrane-bound Steel factor induces more persistent tyrosine kinase activation and longer life span of c-kit gene-encoded protein than its soluble form. Blood 1995;85:641-649.
-
(1995)
Blood
, vol.85
, pp. 641-649
-
-
Miyazawa, K.1
Williams, D.A.2
Gotoh, A.3
Nishimaki, J.4
Broxmeyer, H.E.5
Toyama, K.6
-
116
-
-
0025851410
-
Fibronectin and VLA-4 in haematopoietic stem cell-microenvironment interactions
-
Williams DA, Rios M, Stephens C, Patel VP. Fibronectin and VLA-4 in haematopoietic stem cell-microenvironment interactions. Nature 1991;352:438-441.
-
(1991)
Nature
, vol.352
, pp. 438-441
-
-
Williams, D.A.1
Rios, M.2
Stephens, C.3
Patel, V.P.4
-
117
-
-
0028971211
-
The VLA4/VCAM-1 adhesion pathway defines contrasting mechanisms of lodgement of transplanted murine hemopoietic progenitors between bone marrow and spleen
-
Papayannopoulou T, Craddock C, Nakamoto B, Priestley GV, Wolf NS. The VLA4/VCAM-1 adhesion pathway defines contrasting mechanisms of lodgement of transplanted murine hemopoietic progenitors between bone marrow and spleen. Proc Natl Acad Sci USA 1995;92:9647-9651.
-
(1995)
Proc Natl Acad Sci USA
, vol.92
, pp. 9647-9651
-
-
Papayannopoulou, T.1
Craddock, C.2
Nakamoto, B.3
Priestley, G.V.4
Wolf, N.S.5
-
118
-
-
0345491600
-
Deletion of alpha4 integrins from adult hematopoietic cells reveals roles in homeostasis, regeneration, and homing
-
Scott LM, Priestley GV, Papayannopoulou T. Deletion of alpha4 integrins from adult hematopoietic cells reveals roles in homeostasis, regeneration, and homing. Mol Cell Biol 2003;23:9349-9360.
-
(2003)
Mol Cell Biol
, vol.23
, pp. 9349-9360
-
-
Scott, L.M.1
Priestley, G.V.2
Papayannopoulou, T.3
-
119
-
-
0032700438
-
Rho GTPases control migration and polarization of adhesion molecules and cytoskeletal ERM components in T lymphocytes
-
del Pozo MA, Vicente-Manzanares M, Tejedor R, Serrador JM, Sanchez-Madrid F. Rho GTPases control migration and polarization of adhesion molecules and cytoskeletal ERM components in T lymphocytes. Eur J Immunol 1999;29:3609-3620.
-
(1999)
Eur J Immunol
, vol.29
, pp. 3609-3620
-
-
del Pozo, M.A.1
Vicente-Manzanares, M.2
Tejedor, R.3
Serrador, J.M.4
Sanchez-Madrid, F.5
-
121
-
-
0026767488
-
Steel factor stimulates the tyrosine phosphorylation of the proto-oncogene product, p95vav, in human hemopoietic cells
-
Alai M, Mui AL, Cutler RL, Bustelo XR, Barbacid M, Krystal G. Steel factor stimulates the tyrosine phosphorylation of the proto-oncogene product, p95vav, in human hemopoietic cells. J Biol Chem 1992;267:18021-18025.
-
(1992)
J Biol Chem
, vol.267
, pp. 18021-18025
-
-
Alai, M.1
Mui, A.L.2
Cutler, R.L.3
Bustelo, X.R.4
Barbacid, M.5
Krystal, G.6
-
122
-
-
0142084736
-
Hematopoietic cell regulation by Rac1 and Rac2 guanosine triphosphatases
-
Gu Y, et al. Hematopoietic cell regulation by Rac1 and Rac2 guanosine triphosphatases. Science 2003;302:445-449.
-
(2003)
Science
, vol.302
, pp. 445-449
-
-
Gu, Y.1
-
123
-
-
0141923912
-
Lysophospholipids synergistically promote primitive hematopoietic cell chemotaxis via a mechanism involving Vav 1
-
Whetton AD, Lu Y, Pierce A, Carney L, Spooncer E. Lysophospholipids synergistically promote primitive hematopoietic cell chemotaxis via a mechanism involving Vav 1. Blood 2003;102:2798-2802.
-
(2003)
Blood
, vol.102
, pp. 2798-2802
-
-
Whetton, A.D.1
Lu, Y.2
Pierce, A.3
Carney, L.4
Spooncer, E.5
-
124
-
-
3242799065
-
Localization of Rac2 via the C terminus and aspartic acid 150 specifies superoxide generation, actin polarity and chemotaxis in neutrophils
-
Filippi MD, Harris CE, Meller J, Gu Y, Zheng Y, Williams DA. Localization of Rac2 via the C terminus and aspartic acid 150 specifies superoxide generation, actin polarity and chemotaxis in neutrophils. Nat Immunol 2004;5:744-751.
-
(2004)
Nat Immunol
, vol.5
, pp. 744-751
-
-
Filippi, M.D.1
Harris, C.E.2
Meller, J.3
Gu, Y.4
Zheng, Y.5
Williams, D.A.6
-
125
-
-
0035826843
-
Rac and Cdc42 GTPases control hematopoietic stem cell shape, adhesion, migration, and mobilization
-
Yang FC, et al. Rac and Cdc42 GTPases control hematopoietic stem cell shape, adhesion, migration, and mobilization. Proc Natl Acad Sci USA 2001;98:5614-5618.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 5614-5618
-
-
Yang, F.C.1
-
126
-
-
79959327133
-
Guanine nucleotide exchange factor Vav1 regulates perivascular homing and bone marrow retention of hematopoietic stem and progenitor cells
-
Sanchez-Aguilera A, et al. Guanine nucleotide exchange factor Vav1 regulates perivascular homing and bone marrow retention of hematopoietic stem and progenitor cells. Proc Natl Acad Sci USA 2011;108:9607-9612.
-
(2011)
Proc Natl Acad Sci USA
, vol.108
, pp. 9607-9612
-
-
Sanchez-Aguilera, A.1
-
127
-
-
84878380745
-
The Rac GTPase effector p21-activated kinase is essential for hematopoietic stem/progenitor cell migration and engraftment
-
Dorrance AM, et al. The Rac GTPase effector p21-activated kinase is essential for hematopoietic stem/progenitor cell migration and engraftment. Blood 2013;121:2474-2482.
-
(2013)
Blood
, vol.121
, pp. 2474-2482
-
-
Dorrance, A.M.1
-
128
-
-
41449118699
-
The transcription factor EGR1 controls both the proliferation and localization of hematopoietic stem cells
-
Min IM, Pietramaggiori G, Kim FS, Passegue E, Stevenson KE, Wagers AJ. The transcription factor EGR1 controls both the proliferation and localization of hematopoietic stem cells. Cell Stem Cell 2008;2:380-391.
-
(2008)
Cell Stem Cell
, vol.2
, pp. 380-391
-
-
Min, I.M.1
Pietramaggiori, G.2
Kim, F.S.3
Passegue, E.4
Stevenson, K.E.5
Wagers, A.J.6
-
129
-
-
84877757129
-
Klf5 controls bone marrow homing of stem cells and progenitors through Rab5-mediated beta1/beta2-integrin trafficking
-
Taniguchi Ishikawa E, et al. Klf5 controls bone marrow homing of stem cells and progenitors through Rab5-mediated beta1/beta2-integrin trafficking. Nat Commun 2013;4:1660.
-
(2013)
Nat Commun
, vol.4
, pp. 1660
-
-
Taniguchi Ishikawa, E.1
-
130
-
-
0025001894
-
Stem cell factor is encoded at the Sl locus of the mouse and is the ligand for the c-kit tyrosine kinase receptor
-
Zsebo KM, et al. Stem cell factor is encoded at the Sl locus of the mouse and is the ligand for the c-kit tyrosine kinase receptor. Cell 1990;63:213-224.
-
(1990)
Cell
, vol.63
, pp. 213-224
-
-
Zsebo, K.M.1
-
131
-
-
84875228640
-
Epidermal growth factor regulates hematopoietic regeneration after radiation injury
-
Doan PL, et al. Epidermal growth factor regulates hematopoietic regeneration after radiation injury. Nat Med 2013;19:295-304.
-
(2013)
Nat Med
, vol.19
, pp. 295-304
-
-
Doan, P.L.1
-
132
-
-
84860899357
-
EGR1 and the ERK-ERF axis drive mammary cell migration in response to EGF
-
Tarcic G, et al. EGR1 and the ERK-ERF axis drive mammary cell migration in response to EGF. FASEB J 2012;26:1582-1592.
-
(2012)
FASEB J
, vol.26
, pp. 1582-1592
-
-
Tarcic, G.1
-
133
-
-
0035021950
-
ERK induces p35, a neuron-specific activator of Cdk5, through induction of Egr1
-
Harada T, Morooka T, Ogawa S, Nishida E. ERK induces p35, a neuron-specific activator of Cdk5, through induction of Egr1. Nat Cell Biol 2001;3:453-459.
-
(2001)
Nat Cell Biol
, vol.3
, pp. 453-459
-
-
Harada, T.1
Morooka, T.2
Ogawa, S.3
Nishida, E.4
-
134
-
-
34247621290
-
Rho GTPase Cdc42 coordinates hematopoietic stem cell quiescence and niche interaction in the bone marrow
-
Yang L, Wang L, Geiger H, Cancelas JA, Mo J, Zheng Y. Rho GTPase Cdc42 coordinates hematopoietic stem cell quiescence and niche interaction in the bone marrow. Proc Natl Acad Sci USA 2007;104:5091-5096.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 5091-5096
-
-
Yang, L.1
Wang, L.2
Geiger, H.3
Cancelas, J.A.4
Mo, J.5
Zheng, Y.6
-
135
-
-
33749365721
-
Increased hematopoietic stem cell mobilization in aged mice
-
Xing Z, et al. Increased hematopoietic stem cell mobilization in aged mice. Blood 2006;108:2190-2197.
-
(2006)
Blood
, vol.108
, pp. 2190-2197
-
-
Xing, Z.1
-
136
-
-
84864194496
-
Noncanonical Wnt signaling maintains hematopoietic stem cells in the niche
-
Sugimura R, et al. Noncanonical Wnt signaling maintains hematopoietic stem cells in the niche. Cell 2012;150:351-365.
-
(2012)
Cell
, vol.150
, pp. 351-365
-
-
Sugimura, R.1
-
137
-
-
84860634046
-
Cdc42 activity regulates hematopoietic stem cell aging and rejuvenation
-
Florian MC, et al. Cdc42 activity regulates hematopoietic stem cell aging and rejuvenation. Cell Stem Cell 2012;10:520-530.
-
(2012)
Cell Stem Cell
, vol.10
, pp. 520-530
-
-
Florian, M.C.1
-
138
-
-
78649439321
-
Asymmetric cell division: recent developments and their implications for tumour biology
-
Knoblich JA. Asymmetric cell division: recent developments and their implications for tumour biology. Nat Rev Mol Cell Biol 2010;11:849-860.
-
(2010)
Nat Rev Mol Cell Biol
, vol.11
, pp. 849-860
-
-
Knoblich, J.A.1
-
139
-
-
0037385561
-
A polarity complex of mPar-6 and atypical PKC binds, phosphorylates and regulates mammalian Lgl
-
Plant PJ, et al. A polarity complex of mPar-6 and atypical PKC binds, phosphorylates and regulates mammalian Lgl. Nat Cell Biol 2003;5:301-308.
-
(2003)
Nat Cell Biol
, vol.5
, pp. 301-308
-
-
Plant, P.J.1
-
140
-
-
35548977489
-
Cdc42 acts downstream of Bazooka to regulate neuroblast polarity through Par-6 aPKC
-
Atwood SX, Chabu C, Penkert RR, Doe CQ, Prehoda KE. Cdc42 acts downstream of Bazooka to regulate neuroblast polarity through Par-6 aPKC. J Cell Sci 2007;120:3200-3206.
-
(2007)
J Cell Sci
, vol.120
, pp. 3200-3206
-
-
Atwood, S.X.1
Chabu, C.2
Penkert, R.R.3
Doe, C.Q.4
Prehoda, K.E.5
-
141
-
-
0034683578
-
Drosophila atypical protein kinase C associates with Bazooka and controls polarity of epithelia and neuroblasts
-
Wodarz A, Ramrath A, Grimm A, Knust E. Drosophila atypical protein kinase C associates with Bazooka and controls polarity of epithelia and neuroblasts. J Cell Biol 2000;150:1361-1374.
-
(2000)
J Cell Biol
, vol.150
, pp. 1361-1374
-
-
Wodarz, A.1
Ramrath, A.2
Grimm, A.3
Knust, E.4
-
142
-
-
35848948403
-
Imaging hematopoietic precursor division in real time
-
Wu M, et al. Imaging hematopoietic precursor division in real time. Cell Stem Cell 2007;1:541-554.
-
(2007)
Cell Stem Cell
, vol.1
, pp. 541-554
-
-
Wu, M.1
-
143
-
-
77955512823
-
Regulation of myeloid leukaemia by the cell-fate determinant Musashi
-
Ito T, et al. Regulation of myeloid leukaemia by the cell-fate determinant Musashi. Nature 2010;466:765-768.
-
(2010)
Nature
, vol.466
, pp. 765-768
-
-
Ito, T.1
-
144
-
-
64749091867
-
Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia
-
Zhao C, et al. Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia. Nature 2009;458:776-779.
-
(2009)
Nature
, vol.458
, pp. 776-779
-
-
Zhao, C.1
-
145
-
-
34249803833
-
Normal hemopoiesis and lymphopoiesis in the combined absence of numb and numblike
-
Wilson A, et al. Normal hemopoiesis and lymphopoiesis in the combined absence of numb and numblike. J Immunol 2007;178:6746-6751.
-
(2007)
J Immunol
, vol.178
, pp. 6746-6751
-
-
Wilson, A.1
-
146
-
-
79959968305
-
Atypical protein kinase C (aPKCzeta and aPKClambda) is dispensable for mammalian hematopoietic stem cell activity and blood formation
-
Sengupta A, et al. Atypical protein kinase C (aPKCzeta and aPKClambda) is dispensable for mammalian hematopoietic stem cell activity and blood formation. Proc Natl Acad Sci USA 2011;108:9957-9962.
-
(2011)
Proc Natl Acad Sci USA
, vol.108
, pp. 9957-9962
-
-
Sengupta, A.1
-
147
-
-
84874525399
-
The cell fate determinant L1gl1 influences HSC fitness and prognosis in AML
-
Heidel FH, et al. The cell fate determinant L1gl1 influences HSC fitness and prognosis in AML. J Exp Med 2012;210:15-22.
-
(2012)
J Exp Med
, vol.210
, pp. 15-22
-
-
Heidel, F.H.1
-
148
-
-
84861813715
-
Sequential gain of mutations in severe congenital neutropenia progressing to acute myeloid leukemia
-
Beekman R, et al. Sequential gain of mutations in severe congenital neutropenia progressing to acute myeloid leukemia. Blood 2012;119:5071-5077.
-
(2012)
Blood
, vol.119
, pp. 5071-5077
-
-
Beekman, R.1
-
149
-
-
23844542698
-
Rac GTPases differentially integrate signals regulating hematopoietic stem cell localization
-
Cancelas JA, Lee AW, Prabhakar R, Stringer KF, Zheng Y, Williams DA. Rac GTPases differentially integrate signals regulating hematopoietic stem cell localization. Nat Med 2005;11:886-891.
-
(2005)
Nat Med
, vol.11
, pp. 886-891
-
-
Cancelas, J.A.1
Lee, A.W.2
Prabhakar, R.3
Stringer, K.F.4
Zheng, Y.5
Williams, D.A.6
-
150
-
-
15544385625
-
Rac2-deficient hematopoietic stem cells show defective interaction with the hematopoietic microenvironment and long-term engraftment failure
-
Jansen M, Yang FC, Cancelas JA, Bailey JR, Williams DA. Rac2-deficient hematopoietic stem cells show defective interaction with the hematopoietic microenvironment and long-term engraftment failure. Stem Cells 2005;23:335-346.
-
(2005)
Stem Cells
, vol.23
, pp. 335-346
-
-
Jansen, M.1
Yang, F.C.2
Cancelas, J.A.3
Bailey, J.R.4
Williams, D.A.5
-
151
-
-
41949097347
-
Cross-talk between RhoH and Rac1 in regulation of actin cytoskeleton and chemotaxis of hematopoietic progenitor cells
-
Chae HD, Lee KE, Williams DA, Gu Y. Cross-talk between RhoH and Rac1 in regulation of actin cytoskeleton and chemotaxis of hematopoietic progenitor cells. Blood 2008;111:2597-2605.
-
(2008)
Blood
, vol.111
, pp. 2597-2605
-
-
Chae, H.D.1
Lee, K.E.2
Williams, D.A.3
Gu, Y.4
-
152
-
-
33748703837
-
Inhibition of RhoA GTPase activity enhances hematopoietic stem and progenitor cell proliferation and engraftment
-
Ghiaur G, Lee A, Bailey J, Cancelas JA, Zheng Y, Williams DA. Inhibition of RhoA GTPase activity enhances hematopoietic stem and progenitor cell proliferation and engraftment. Blood 2006;108:2087-2094.
-
(2006)
Blood
, vol.108
, pp. 2087-2094
-
-
Ghiaur, G.1
Lee, A.2
Bailey, J.3
Cancelas, J.A.4
Zheng, Y.5
Williams, D.A.6
-
153
-
-
70449489421
-
Loss of the Rho GTPase activating protein p190-B enhances hematopoietic stem cell engraftment potential
-
Xu H, et al. Loss of the Rho GTPase activating protein p190-B enhances hematopoietic stem cell engraftment potential. Blood 2009;114:3557-3566.
-
(2009)
Blood
, vol.114
, pp. 3557-3566
-
-
Xu, H.1
-
154
-
-
84885358599
-
RhoA GTPase controls cytokinesis and programmed necrosis of hematopoietic progenitors
-
in press
-
Zhou X, et al. RhoA GTPase controls cytokinesis and programmed necrosis of hematopoietic progenitors. J Exp Med 2013; (in press).
-
(2013)
J Exp Med
-
-
Zhou, X.1
|