Filamin is essential in actin cytoskeletal assembly mediated by p21-activated kinase 1

Nature Cell Biology

Volumn 4, Issue 9, 2002, Pages 681-690

  Vadlamudi, Ratna K ^a   Li, Feng ^a   Adam, Liana ^a   Nguyen, Diep ^a   Ohta, Yasutaka ^b   Stossel, Thomas P ^b   Kumar, Rakesh ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; AMINO ACID; CYTOSKELETON PROTEIN; FILAMIN; GUANOSINE TRIPHOSPHATASE; PROTEIN CDC42; PROTEIN P21; PROTEIN SERINE THREONINE KINASE; RAC PROTEIN; SERINE;

AMINO TERMINAL SEQUENCE; ARTICLE; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CELL MEMBRANE; CELL STRUCTURE; CONTROLLED STUDY; CYTOSKELETON; ENZYME ACTIVATION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN ASSEMBLY; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN TARGETING; SIGNAL TRANSDUCTION; TANDEM REPEAT; TWO HYBRID SYSTEM;

ACTINS; BINDING SITES; CELL LINE; CONTRACTILE PROTEINS; CYTOSKELETON; ENZYME ACTIVATION; GREEN FLUORESCENT PROTEINS; HUMANS; LUMINESCENT PROTEINS; MICROFILAMENT PROTEINS; MITOGEN-ACTIVATED PROTEIN KINASES; MUTATION; PHOSPHORYLATION; PROTEIN KINASES; PROTEIN-SERINE-THREONINE KINASES; RECOMBINANT FUSION PROTEINS; SIGNAL TRANSDUCTION; SUBSTRATE SPECIFICITY; TWO-HYBRID SYSTEM TECHNIQUES;

EID: 0036711657     PISSN: 14657392     EISSN: None     Source Type: Journal    
DOI: 10.1038/ncb838     Document Type: Article

References (35)

1. Rho GTPases and the actin cytoskeleton
2. The small GTP-binding protein Rac regulates growth factor-induced membrane ruffling
3. The GTPase-activating protein n-chimaerin cooperates with Rac1 and Cdc42Hs to induce the formation of lamellipodia and filopodia
4. Rho GTPases and their effector proteins
5. A brain serine/threonine protein kinase activated by Cdc42 and Rac1
6. Human p21-activated kinase (Pak1) regulates actin organization in mammalian cells
7. P21-activated protein kinase: A crucial component of morphological signaling?
8. A conserved negative regulatory region in αPAK: Inhibition of PAK kinases reveals their morphological roles downstream of Cdc42 and Rac1
9. Expression of constitutively active α-PAK reveals effects of the kinase on actin and focal complexes
10. Localization of p21-activated kinase 1 (PAK1) to pinocytic vesicles and cortical actin structures in stimulated cells
11. Paxillin LD4 motif binds PAK and PIX through a novel 95-kD ankyrin repeat, ARF-GAP protein: A role in cytoskeletal remodeling
12. Differential effects of PAK1-activating mutations reveal activity-dependent and -independent effects on cytoskeletal regulation
13. Activation of LIM-kinase by Pak1 couples Rac/Cdc42 GTPase signaling to actin cytoskeletal dynamics
14. The role of the cortical cytoskeleton: F-actin crosslinking proteins protect against osmotic stress, ensure cell size, cell shape and motility, and contribute to phagocytosis and development
15. Filamins as integrators of cell mechanics and signalling
16. Phosphorylation of actin-binding protein 280 by growth factors is mediated by p90 ribosomal protein S6 kinase
17. Human endothelial actin-binding protein (ABP-280, nonmuscle filamin): A molecular leaf spring
18. Actin-binding and dimerization domains of HeLa cell filamin
19. Actin-binding protein requirement for cortical stability and efficient locomotion
20. Mutations in filamin 1 prevent migration of cerebral cortical neurons in human periventricular heterotopia
21. Wrch-1, a novel member of the Rho gene family that is regulated by Wnt-1
22. Heregulin regulates cytoskeletal reorganization and cell migration through the p21-activated kinase-1 via phosphatidylinositol-3 kinase
23. Regulatable expression of p21-activated kinase-1 promotes anchorage-independent growth and abnormal organization of mitotic spindles in human epithelial breast cancer cells
24. A GTPase-independent mechanism of p21-activated kinase activation. Regulation by sphingosine and other biologically active lipids
25. Etk/Bmx tyrosine kinase activates Pak1 and regulates tumorigenicity of breast cancer cells
26. Rac p21 is involved in insulin-induced membrane ruffling and Rho p21 is involved in hepatocyte growth factor- and 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced membrane ruffling in KB cells
27. Pak to the future
28. Regulation of microfilament reorganization and invasiveness of breast cancer cells by kinase dead p21-activated kinase 1
29. Actin-binding protem-280 binds the stress-activated protein kinase (SAPK) activator SEK-1 and is required for tumor necrosis factor-α activation of SAPK in melanoma cells
30. Identification of filamin as a novel ligand for caveolin-1: Evidence for the organization of caveolin-1-associated membrane domains by the actin cytoskeleton
31. PAK2 is cleaved and activated during hyperosmotic shock-induced apoptosis via a caspase-dependent mechanism: Evidence for the involvement of oxidative stress
32. The small GTPase RalA targets filamin to induce filopodia
33. Temporal and spatial distribution of activated Pak1 in fibroblasts
34. A naturally occurring MTA1 variant sequesters estrogen receptor-α in the cytoplasm
35. Transcriptional repression of estrogen receptor by metastasis-associated protein 1 corepressor, a component of histone deacetylase and nucleosome remodelling complexes