Signal transduction pathways involving the small G proteins rac and CDC42 and phosphoinositide kinases

Advances in Enzyme Regulation

Volumn 37, Issue , 1997, Pages 377-390

  Carpenter, Christopher L ^a   Tolias, Kimberley F ^a   Couvillon, Anthony C ^a   Hartwig, John H ^b  

^a BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; CELL CYCLE PROTEIN; G25K PROTEIN; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE TRIPHOSPHATASE; HYBRID PROTEIN; PHOSPHATIDYLINOSITOL; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE; PHOSPHATIDYLINOSITOL KINASE; PHOSPHOTRANSFERASE; RAC G PROTEIN;

ACTIN POLYMERIZATION; ANIMAL; ANIMAL CELL; BIOSYNTHESIS; CELL STRAIN 3T3; CONFERENCE PAPER; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME BINDING; ENZYME LOCALIZATION; ENZYME SPECIFICITY; HUMAN; METABOLISM; MOUSE; NONHUMAN; PROTEIN PROTEIN INTERACTION; RAT; SIGNAL TRANSDUCTION; THROMBOCYTE;

1-PHOSPHATIDYLINOSITOL 3-KINASE; 1-PHOSPHATIDYLINOSITOL 4-KINASE; 3T3 CELLS; ACTINS; ANIMALS; BLOOD PLATELETS; CDC42 GTP-BINDING PROTEIN; CELL CYCLE PROTEINS; GTP PHOSPHOHYDROLASES; GTP-BINDING PROTEINS; HUMANS; MICE; PHOSPHATIDYLINOSITOL 4,5-DIPHOSPHATE; PHOSPHATIDYLINOSITOLS; RAC GTP-BINDING PROTEINS; RATS; RECOMBINANT FUSION PROTEINS; SIGNAL TRANSDUCTION;

ANIMALIA;

EID: 0030820404     PISSN: 00652571     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S0065-2571(96)00005-2     Document Type: Conference Paper

References (26)

1. 1. C. L. CARPENTER, Intracellular signals and the cytoskeleton: the interactions of phosphoinositide kinases and small G proteins in adherence, ruffling and motility, Sem. Cell Dev. Biol. 7, 691-697 In press (1996).
2. 2. A. J. RIDLEY, Rho-related proteins: actin cytoskeleton and cell cycle, Curr. Opin. Genet. Dev. 5, 24-30 (1995).
3. 3. M. S. BOGUSKI and F. MCCORMICK, Proteins regulating ras and its relatives, Nature 366, 643-654 (1993).
4. 4. A. J. RIDLEY and A. HALL, The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors, Cell 70, 389-399 (1992).
5. 5. T. NISHIYAMA, T. SASAKI, K. TAKAISHI, M. KATO, H. YAKU, K. ARAKI, Y. MATSUURA and Y. TAKAI, Rac p21 is involved in insulin-induced membrane ruffling and rho p21 is involved in hepatocyte growth factor-and 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced membrane ruffling in KB cells, Mol. Cell. Biol. 14, 2447-2456 (1994).
6. 6. A. J. RIDLEY, H. F. PATERSON, C. L. JOHNSTON, D. DIEKMANN and A. HALL, The small GTP-binding protein rac regulates growth factor-induced membrane ruffling, Cell 70, 401-410 (1992).
7. 7. C. D. NOBES and A. HALL, Rho, Rac and Cdc42 GTPases regulate the assembly of multimolecular complexes associated with actin stress fibers, lamellipodia and filopodia, Cell 81, 53-62 (1995).
8. 8. R. KOZMA, S. AHMED, A. BEST and L. LIM, The ras-related protein Cdc42Hs and bradykinin promote formation of peripheral actin microspikes and filopoida in Swiss 3T3 fibroblasts, Mol. Cell. Biol. 15, 1942-1952 (1995).
9. 9. A. RIDLEY and A. HALL, Signal transduction pathways regulating Rho-mediated stress fibre formation: requirement for a tyrosine kinase, EMBO J. 13, 2600-2610 (1994).
10. 10. T. P. STOSSEL, On the crawling of animal cells, Science 260, 1086-1094 (1993).
11. 11. K. KOTANI, K. YONEZAWA, K. HARA, H. UEDA, Y. KITAMURA, H. SAKAUE, A. ANDO, A. CHAVANIEU, B. CALA, F. GRIGORESCU, M. NISHITAMA, M. D. WATERFIELD and M. KASUGA, Involvement of phosphoinositide 3-kinase in insulin-or IGF-1 induced membrane ruffling, EMBO J. 13, 2313-2321 (1994).
12. 12. C. D. NOBES, P. HAWKINS, L. STEPHENS and A. HALL, Activation of the small GTP-binding proteins rho and rac by growth factor receptors, J. Cell. Science 108, 225-233 (1995).
13. 13. S. WENNSTROM, P. HAWKINS, F. COOKE, K. HARA, K. YONEZAWA, M. KASUGA, T. JACKSON, L. CLAESSON-WELSH and L. STEPHENS, Activation of phosphoinositide 3-kinase is required for PDGF-stimulated membrane ruffling, Current Biol. 4, 385-393 (1994).
14. 14. V. KUNDRA, J. A. ESCOBEDO, A. KAZLAUSKAS, H. K. KIM, S. G. RHE, L. T. WILLIAMS and B. R. ZETTER, Regulation of chemotaxis by the platelet-derived growth factor receptor-beta, Nature 367, 474-476 (1994).
15. 15. S. WENNSTROM, A. SIEGBAHN, K. YOKOTE, A. K. ARVIDSSON, C. H. HELDIN, S. MORI and W. L. CLAESSON, Membrane ruffling and chemotaxis transduced by the PDGF beta-receptor require the binding site for phosphatidylinositol 3′ kinase, Oncogene 9, 651-660 (1994).
16. 16. R. KAPELLER, A. TOKER, L. C. CANTLEY and C. L. CARPENTER, Phosphoinositide 3-kinase binds constitutively to alpha/beta-tubulin and binds to gamma-tubulin in response to insulin, J. Biol. Chem. 270, 25985-25991 (1995).
17. 17. C. L. CARPENTER, B. C. DUCKWORTH, K. R. AUGER, B. COHEN, B. S. SCHAFFHAUSEN and L. C. CANTLEY, Purification and characterization of phosphoinositide 3-kinase from rat liver, J. Biol. Chem. 265, 19704-19711 (1990).
18. 18. K. R. AUGER, C. L. CARPENTER, L. C. CANTLEY and L. VARTICOVSKI, Phosphatidylinositol 3-kinase and its novel product, phosphatidylinositol 3-phosphate, are present in Saccharomyces cerevisiae, J. Biol. Chem. 264, 20181-20184 (1989).
19. 19. C. E. BAZENET, A. R. RUANO, J. L. BROCKMAN and R. A. ANDERSON, The human erythrocyte contains two forms of phosphatidylinositol-4-phosphate 5-kinase which are differentially active toward membranes, J. Biol. Chem. 265, 18012-18022 (1990).
20. 20. G. H. JENKINS, P. L. FISETTE and R. A. ANDERSON, Type I phosphatidylinositol 4-phosphate 5-kinase isoforms are specifically stimulated by phosphatidic acid, J. Biol. Chem. 269, 11547-11554 (1994).
21. 21. C. L. CARPENTER, K. R. AUGER, B. C. DUCKWORTH, W. M. HOU, B. SCHAFFHAUSEN and L. C. CANTLEY, A tightly associated serine/threonine protein kinase regulates phosphoinositide 3-kinase activity, Mol Cell Biol. 13, 1657-1665 (1993).
22. 22. J. H. HARTWIG, G. BOKOCH, C. CARPENTER, P. JANMEY, L. TAYLOR, A. TOKER and T. P. STOSSEL, Thrombin receptor ligation and activated Rac uncap actin filament barbed end through phosphoinositide synthesis in permeabilized platelets, Cell 82, 643-653 (1995).
23. 23. X.-D. REN, G. M. BOKOCH, A. TRAYNOR-KAPLAN, G. H. JENKINS, R. A. ANDERSON and M. A. SCHWARTZ, Physical association of the small GTPase Rho with a 68-kDa phosphatidylinositol 4-phosphate 5-kinase in Swiss 3T3 cells, Mol. Biol. Cell. 7, 435-442 (1996).
24. 24. L. D. CHONG, A. TRAYNOR KAPLAN, G. M. BOKOCH and M. A. SCHWARTZ, The small GTP binding protein Rho regulates a phosphatidylinositol 4-phosphate 5-kinase in mammalian cells, Cell 79, 507-513 (1994).
25. 25. K. TOLIAS, L. CANTLEY and C. CARPENTER, Rho family GTPases bind to phosphoinositide kinases, J. Biol. Chem. 270, 17656-17659 (1995).
26. 26. P. T. HAWKINS, A. EGUINOA, R.-G. QIU, D. STOKOE, F. T. COOKE, R. WALTERS, S. WENNSTROM, L. CLAESSON-WELSH, T. EVANS, M. SYMONS and L. STEPHENS, PDGF stimulates an increase in GTP-Rac via activation of phosphoinositide 3-kinase, Current Biol. 5, 393-403 (1995).