-
1
-
-
0030724491
-
Mutation of the mouse klotho gene leads to a syndrome resembling ageing
-
9363890 1:CAS:528:DyaK2sXnt1Cnu70%3D
-
Kuro-o M, Matsumura Y, Aizawa H et al (1997) Mutation of the mouse klotho gene leads to a syndrome resembling ageing. Nature 390:45-51
-
(1997)
Nature
, vol.390
, pp. 45-51
-
-
Kuro-O, M.1
Matsumura, Y.2
Aizawa, H.3
-
2
-
-
24944481544
-
Suppression of aging in mice by the hormone Klotho
-
16123266 1:CAS:528:DC%2BD2MXpvFCisb0%3D
-
Kurosu H, Yamamoto M, Clark JD et al (2005) Suppression of aging in mice by the hormone Klotho. Science 309:1829-1833
-
(2005)
Science
, vol.309
, pp. 1829-1833
-
-
Kurosu, H.1
Yamamoto, M.2
Clark, J.D.3
-
3
-
-
58049172887
-
Klotho gene, phosphocalcic metabolism, and survival in dialysis
-
19121771 1:CAS:528:DC%2BD1MXksl2rs7Y%3D
-
Torres PU, Prié D, Beck L, De Brauwere D, Leroy C, Friedlander G (2009) Klotho gene, phosphocalcic metabolism, and survival in dialysis. J Ren Nutr 19:50-56
-
(2009)
J Ren Nutr
, vol.19
, pp. 50-56
-
-
Torres, P.U.1
Prié, D.2
Beck, L.3
De Brauwere, D.4
Leroy, C.5
Friedlander, G.6
-
4
-
-
84862149482
-
Klotho in health and disease
-
22660551 1:CAS:528:DC%2BC38XotVOjtrs%3D
-
Kuro-o M (2012) Klotho in health and disease. Curr Opin Nephrol Hypertens 21:362-368
-
(2012)
Curr Opin Nephrol Hypertens
, vol.21
, pp. 362-368
-
-
Kuro-O, M.1
-
5
-
-
38949155148
-
Klotho expression in epithelial ovarian cancer and its association with insulin-like growth factors and disease progression
-
18259951 1:CAS:528:DC%2BD1cXhs1Wnsrw%3D
-
Lu L, Katsaros D, Wiley A, de la Longrais IA, Puopolo M, Yu H (2008) Klotho expression in epithelial ovarian cancer and its association with insulin-like growth factors and disease progression. Cancer Invest 26:185-192
-
(2008)
Cancer Invest
, vol.26
, pp. 185-192
-
-
Lu, L.1
Katsaros, D.2
Wiley, A.3
De La Longrais, I.A.4
Puopolo, M.5
Yu, H.6
-
6
-
-
58149229326
-
Klotho: A tumor suppressor and a modulator of the IGF-1 and FGF pathways in human breast cancer
-
18762812 1:CAS:528:DC%2BD1cXhsVenu7vK
-
Wolf I, Levanon-Cohen S, Bose S et al (2008) Klotho: a tumor suppressor and a modulator of the IGF-1 and FGF pathways in human breast cancer. Oncogene 27:7094-7105
-
(2008)
Oncogene
, vol.27
, pp. 7094-7105
-
-
Wolf, I.1
Levanon-Cohen, S.2
Bose, S.3
-
7
-
-
73849140439
-
Functional variant of KLOTHO: A breast cancer risk modifier among BRCA1 mutation carriers of Ashkenazi origin
-
19802015 1:CAS:528:DC%2BD1MXht1Wgsb%2FJ
-
Wolf I, Laitman Y, Rubinek T et al (2010) Functional variant of KLOTHO: a breast cancer risk modifier among BRCA1 mutation carriers of Ashkenazi origin. Oncogene 29:26-33
-
(2010)
Oncogene
, vol.29
, pp. 26-33
-
-
Wolf, I.1
Laitman, Y.2
Rubinek, T.3
-
8
-
-
84865185665
-
The KL-VS sequence variant of Klotho and cancer risk in BRCA1 and BRCA2 mutation carriers
-
22212556 1:CAS:528:DC%2BC38XmtFWgsrs%3D
-
Laitman Y, Kuchenbaecker KB, Rantala J et al (2012) The KL-VS sequence variant of Klotho and cancer risk in BRCA1 and BRCA2 mutation carriers. Breast Cancer Res Treat 132:1119-1126
-
(2012)
Breast Cancer Res Treat
, vol.132
, pp. 1119-1126
-
-
Laitman, Y.1
Kuchenbaecker, K.B.2
Rantala, J.3
-
9
-
-
77954684957
-
Klotho inhibits growth and promotes apoptosis in human lung cancer cell line A549
-
20642846
-
Chen B, Wang X, Zhao W, Wu J (2010) Klotho inhibits growth and promotes apoptosis in human lung cancer cell line A549. J Exp Clin Cancer Res 29:99-106
-
(2010)
J Exp Clin Cancer Res
, vol.29
, pp. 99-106
-
-
Chen, B.1
Wang, X.2
Zhao, W.3
Wu, J.4
-
10
-
-
77952248261
-
The antiaging gene KLOTHO is a novel target for epigenetic silencing inhuman cervical carcinoma
-
20482749
-
Lee J, Jeong DJ, Kim J et al (2010) The antiaging gene KLOTHO is a novel target for epigenetic silencing inhuman cervical carcinoma. Mol Cancer 9:109-118
-
(2010)
Mol Cancer
, vol.9
, pp. 109-118
-
-
Lee, J.1
Jeong, D.J.2
Kim, J.3
-
11
-
-
80052329379
-
Klotho is silenced through promoter hypermethylation in gastric cancer
-
21969138 1:CAS:528:DC%2BC3MXms1Knsbw%3D
-
Wang LJ, Wang X, Wang XJ et al (2011) Klotho is silenced through promoter hypermethylation in gastric cancer. Am J Cancer Res 1:111-119
-
(2011)
Am J Cancer Res
, vol.1
, pp. 111-119
-
-
Wang, L.J.1
Wang, X.2
Wang, X.J.3
-
12
-
-
79960288442
-
KL1 internal repeat mediates klotho tumor suppressor activities and inhibits bFGF and IGF-I signaling in pancreatic cancer
-
21571866 1:CAS:528:DC%2BC3MXos1SmtrY%3D
-
Abramovitz L, Rubinek T, Ligumsky H et al (2011) KL1 internal repeat mediates klotho tumor suppressor activities and inhibits bFGF and IGF-I signaling in pancreatic cancer. Clin Cancer Res 17:4254-4266
-
(2011)
Clin Cancer Res
, vol.17
, pp. 4254-4266
-
-
Abramovitz, L.1
Rubinek, T.2
Ligumsky, H.3
-
13
-
-
0035884617
-
Differential insulin-like growth factor i receptor signaling and function in estrogen receptor (ER)-positive MCF-7 and ER-negative MDA-MB-231 breast cancer cells
-
11559546 1:CAS:528:DC%2BD3MXntFaisL0%3D
-
Bartucci M, Morelli C, Mauro L, Andò S, Surmacz E (2001) Differential insulin-like growth factor I receptor signaling and function in estrogen receptor (ER)-positive MCF-7 and ER-negative MDA-MB-231 breast cancer cells. Cancer Res 61:6747-6754
-
(2001)
Cancer Res
, vol.61
, pp. 6747-6754
-
-
Bartucci, M.1
Morelli, C.2
Mauro, L.3
Andò, S.4
Surmacz, E.5
-
14
-
-
80052332092
-
Klotho, an anti-senescence related gene, is frequently inactivated through promoter hypermethylation in colorectal cancer
-
21523445 1:CAS:528:DC%2BC3MXos1Oit74%3D
-
Pan J, Zhong J, Gan LH et al (2011) Klotho, an anti-senescence related gene, is frequently inactivated through promoter hypermethylation in colorectal cancer. Tumour Biol 32:729-735
-
(2011)
Tumour Biol
, vol.32
, pp. 729-735
-
-
Pan, J.1
Zhong, J.2
Gan, L.H.3
-
15
-
-
84863726107
-
Epigenetic silencing of the tumor suppressor klotho in human breast cancer
-
[Epub ahead of print]
-
Rubinek T, Shulman M, Israeli S, et al. (2011) Epigenetic silencing of the tumor suppressor klotho in human breast cancer. Breast Cancer Res Treat [Epub ahead of print]
-
(2011)
Breast Cancer Res Treat
-
-
Rubinek, T.1
Shulman, M.2
Israeli, S.3
-
16
-
-
79953044634
-
Combined effects of klotho and soluble CD40 ligand on A549 lung cancer cells
-
21308354 1:CAS:528:DC%2BC3MXmtlagt7Y%3D
-
Wang X, Chen B, Xu W, Liu S, Zhao W, Wu J (2011) Combined effects of klotho and soluble CD40 ligand on A549 lung cancer cells. Oncol Rep 25:1465-1472
-
(2011)
Oncol Rep
, vol.25
, pp. 1465-1472
-
-
Wang, X.1
Chen, B.2
Xu, W.3
Liu, S.4
Zhao, W.5
Wu, J.6
-
17
-
-
79953138206
-
Klotho inhibits transforming growth factor-beta1 (TGF-beta1) signaling and suppresses renal fibrosis and cancer metastasis in mice
-
1:CAS:528:DC%2BC3MXislyksr8%3D
-
Doi S, Zou Y, Togao O et al (2011) Klotho inhibits transforming growth factor-beta1 (TGF-beta1) signaling and suppresses renal fibrosis and cancer metastasis in mice. Biol Chem 286:8655-8665
-
(2011)
Biol Chem
, vol.286
, pp. 8655-8665
-
-
Doi, S.1
Zou, Y.2
Togao, O.3
-
18
-
-
84885185681
-
Restoration of klotho expression induces apoptosis and autophagy in hepatocellular carcinoma cells
-
[Epub ahead of print]
-
Shu G, Xie B, Ren F, et al. (2012) Restoration of klotho expression induces apoptosis and autophagy in hepatocellular carcinoma cells. Cell Oncol (Dordr) [Epub ahead of print]
-
(2012)
Cell Oncol (Dordr)
-
-
Shu, G.1
Xie, B.2
Ren, F.3
-
19
-
-
84876503548
-
Epigenetic silencing of Klotho expression correlates with poor prognosis of human hepatocellular carcinoma
-
Xie B, Zhou J, Yuan L, et al. (2012) Epigenetic silencing of Klotho expression correlates with poor prognosis of human hepatocellular carcinoma. Hum Pathol
-
(2012)
Hum Pathol
-
-
Xie, B.1
Zhou, J.2
Yuan, L.3
-
21
-
-
79952455618
-
TOR signaling never gets old: Aging, longevity and TORC1 activity
-
20385253 1:CAS:528:DC%2BC3MXjtFWjtLc%3D
-
Evans DS, Kapahi P, Hsueh WC, Kockel L (2011) TOR signaling never gets old: aging, longevity and TORC1 activity. Ageing Res Rev 10:225-237
-
(2011)
Ageing Res Rev
, vol.10
, pp. 225-237
-
-
Evans, D.S.1
Kapahi, P.2
Hsueh, W.C.3
Kockel, L.4
-
22
-
-
20944440088
-
Tumor development by transgenic expression of a constitutively active insulin-like growth factor i receptor
-
Carboni JM, Lee AV, Hadsell DL et al (2005) Tumor development by transgenic expression of a constitutively active insulin-like growth factor I receptor. Cancer Res 5:3781-3787
-
(2005)
Cancer Res
, vol.5
, pp. 3781-3787
-
-
Carboni, J.M.1
Lee, A.V.2
Hadsell, D.L.3
-
23
-
-
0036559535
-
Elevated levels of IGF-1 receptor convey invasive and metastatic capability in a mouse model of pancreatic islet tumorigenesis
-
12086849 1:CAS:528:DC%2BD38XktlSrtLc%3D
-
Lopez T, Hanahan D (2002) Elevated levels of IGF-1 receptor convey invasive and metastatic capability in a mouse model of pancreatic islet tumorigenesis. Cancer Cell 1:339-353
-
(2002)
Cancer Cell
, vol.1
, pp. 339-353
-
-
Lopez, T.1
Hanahan, D.2
-
24
-
-
22544461679
-
The role of the growth hormone/insulin-like growth factor axis in tumor growth and progression: Lessons from animal models
-
15886048 1:CAS:528:DC%2BD2MXmvVCnu70%3D
-
Yakar S, Leroith D, Brodt P (2005) The role of the growth hormone/insulin-like growth factor axis in tumor growth and progression: Lessons from animal models. Cytokine Growth Factor Rev 16:407-420
-
(2005)
Cytokine Growth Factor Rev
, vol.16
, pp. 407-420
-
-
Yakar, S.1
Leroith, D.2
Brodt, P.3
-
25
-
-
22544461679
-
The role of the growth hormone/insulin-like growth factor axis in tumor growth and progression: Lessons from animal models
-
Yakar S, Leroith D, Brodt P (2005) The role of the growth hormone/insulin-like growth factor axis in tumor growth and progression: Lessons from animal models. Cytokine Growth Factor Rev 6:407-420
-
(2005)
Cytokine Growth Factor Rev
, vol.6
, pp. 407-420
-
-
Yakar, S.1
Leroith, D.2
Brodt, P.3
-
26
-
-
79955463824
-
Klotho is a novel biomarker for good survival in resected large cell neuroendocrine carcinoma of the lung
-
21075474
-
Usuda J, Ichinose S, Ishizumi T et al (2011) Klotho is a novel biomarker for good survival in resected large cell neuroendocrine carcinoma of the lung. Lung Cancer 72:355-359
-
(2011)
Lung Cancer
, vol.72
, pp. 355-359
-
-
Usuda, J.1
Ichinose, S.2
Ishizumi, T.3
-
27
-
-
80053643828
-
Klotho predicts good clinical outcome in patients with limited-disease small cell lung cancer who received surgery
-
21529984
-
Usuda J, Ichinose S, Ishizumi T et al (2011) Klotho predicts good clinical outcome in patients with limited-disease small cell lung cancer who received surgery. Lung Cancer 74:332-337
-
(2011)
Lung Cancer
, vol.74
, pp. 332-337
-
-
Usuda, J.1
Ichinose, S.2
Ishizumi, T.3
-
28
-
-
84874016733
-
Restoration of klotho gene expression induces apoptosis and autophagy in gastric cancer cells: Tumor suppressive role of klotho in gastric cancer
-
23432957 1:CAS:528:DC%2BC3sXnsFKntL8%3D
-
Xie B, Zhou J, Shu G et al (2013) Restoration of klotho gene expression induces apoptosis and autophagy in gastric cancer cells: tumor suppressive role of klotho in gastric cancer. Cancer Cell Int 13:18
-
(2013)
Cancer Cell Int
, vol.13
, pp. 18
-
-
Xie, B.1
Zhou, J.2
Shu, G.3
-
29
-
-
33746036030
-
Klotho protein promotes adipocyte differentiation
-
16709611 1:CAS:528:DC%2BD28XnsVWms7w%3D
-
Chihara Y, Rakugi H, Ishikawa K et al (2006) Klotho protein promotes adipocyte differentiation. Endocrinology 147:3835-3842
-
(2006)
Endocrinology
, vol.147
, pp. 3835-3842
-
-
Chihara, Y.1
Rakugi, H.2
Ishikawa, K.3
-
30
-
-
77949891834
-
Evidence against a direct role of klotho in insulin resistance
-
19756714 1:CAS:528:DC%2BC3cXps1ajsw%3D%3D
-
Lorenzi O, Veyrat-Durebex C, Wollheim CB et al (2010) Evidence against a direct role of klotho in insulin resistance. Pflugers Arch 459:465-473
-
(2010)
Pflugers Arch
, vol.459
, pp. 465-473
-
-
Lorenzi, O.1
Veyrat-Durebex, C.2
Wollheim, C.B.3
-
31
-
-
36448972266
-
Gene profile analysis implicates Klotho as an important contributor to aging changes in brain white matter of the rhesus monkey
-
17963266
-
Duce JA, Podvin S, Hollander W et al (2008) Gene profile analysis implicates Klotho as an important contributor to aging changes in brain white matter of the rhesus monkey. Glia 56:106-117
-
(2008)
Glia
, vol.56
, pp. 106-117
-
-
Duce, J.A.1
Podvin, S.2
Hollander, W.3
-
32
-
-
72449191689
-
Transcriptional activation of the human Klotho gene by epidermal growth factor in HEK293 cells; Role of Egr-1
-
19913601 1:CAS:528:DC%2BD1MXhsFCksLvL
-
Choi BH, Kim CG, Lim Y, Lee YH, Shin SY (2010) Transcriptional activation of the human Klotho gene by epidermal growth factor in HEK293 cells; role of Egr-1. Gene 450:121-127
-
(2010)
Gene
, vol.450
, pp. 121-127
-
-
Choi, B.H.1
Kim, C.G.2
Lim, Y.3
Lee, Y.H.4
Shin, S.Y.5
-
33
-
-
84872496432
-
MicroRNAs as potential biomarkers in human solid tumors
-
Shen J, Stass SA, Jiang F (2013) MicroRNAs as potential biomarkers in human solid tumors. Cancer Lett 329:125-136
-
(2013)
Cancer Lett
, vol.329
, pp. 125-136
-
-
Shen, J.1
Stass, S.A.2
Jiang, F.3
-
34
-
-
68649100731
-
Epigenetic Control of MicroRNA Expression and Aging
-
19881911 1:CAS:528:DC%2BD1MXmslans7s%3D
-
Liang R, Bates DJ, Wang E (2009) Epigenetic Control of MicroRNA Expression and Aging. Curr Genomics 10:184-193
-
(2009)
Curr Genomics
, vol.10
, pp. 184-193
-
-
Liang, R.1
Bates, D.J.2
Wang, E.3
-
35
-
-
46649098396
-
Murine microRNAs implicated in liver functions and aging process
-
18561983 1:CAS:528:DC%2BD1cXosVOnsbw%3D
-
Maes OC, An J, Sarojini H, Wang E (2008) Murine microRNAs implicated in liver functions and aging process. Mech Ageing Dev 129:534-541
-
(2008)
Mech Ageing Dev
, vol.129
, pp. 534-541
-
-
Maes, O.C.1
An, J.2
Sarojini, H.3
Wang, E.4
-
36
-
-
8444251784
-
The Wnt signaling pathway in development and disease
-
15473860 1:CAS:528:DC%2BD2cXhtVejsr7I
-
Logan CY, Nusse R (2004) The Wnt signaling pathway in development and disease. Annu Rev Cell Dev Biol 20:781-810
-
(2004)
Annu Rev Cell Dev Biol
, vol.20
, pp. 781-810
-
-
Logan, C.Y.1
Nusse, R.2
-
37
-
-
42549164807
-
Wnt signalling and its impact on development and cancer
-
18432252 1:CAS:528:DC%2BD1cXltVGlu7c%3D
-
Klaus A, Birchmeier W (2008) Wnt signalling and its impact on development and cancer. Nat Rev Cancer 8:387-398
-
(2008)
Nat Rev Cancer
, vol.8
, pp. 387-398
-
-
Klaus, A.1
Birchmeier, W.2
-
38
-
-
12144291274
-
Epigenetic inactivation of SFRP genes allows constitutive WNT signaling in colorectal cancer
-
15034581 1:CAS:528:DC%2BD2cXis1ahtrY%3D
-
Suzuki H, Watkins DN, Jair KW et al (2004) Epigenetic inactivation of SFRP genes allows constitutive WNT signaling in colorectal cancer. Nat Genet 36:417-422
-
(2004)
Nat Genet
, vol.36
, pp. 417-422
-
-
Suzuki, H.1
Watkins, D.N.2
Jair, K.W.3
-
39
-
-
33646247418
-
Combination analysis of hypermethylated Wnt-antagonist family genes as a novel epigenetic biomarker panel for bladder cancer detection
-
16609023 1:CAS:528:DC%2BD28XjtlChsrs%3D
-
Urakami S, Shiina H, Enokida H et al (2006) Combination analysis of hypermethylated Wnt-antagonist family genes as a novel epigenetic biomarker panel for bladder cancer detection. Clin Cancer Res 12:2109-2116
-
(2006)
Clin Cancer Res
, vol.12
, pp. 2109-2116
-
-
Urakami, S.1
Shiina, H.2
Enokida, H.3
-
40
-
-
34447521472
-
Frequent epigenetic inactivation of SFRP genes and constitutive activation of Wnt signaling in gastric cancer
-
17297461 1:CAS:528:DC%2BD2sXnsFOisrk%3D
-
Nojima M, Suzuki H, Toyota M et al (2007) Frequent epigenetic inactivation of SFRP genes and constitutive activation of Wnt signaling in gastric cancer. Oncogene 26:4699-4713
-
(2007)
Oncogene
, vol.26
, pp. 4699-4713
-
-
Nojima, M.1
Suzuki, H.2
Toyota, M.3
-
41
-
-
40849116461
-
Frequent epigenetic inactivation of Wnt antagonist genes in breast cancer
-
18283316 1:CAS:528:DC%2BD1cXjtlGktb0%3D
-
Suzuki H, Toyota M, Carraway H et al (2008) Frequent epigenetic inactivation of Wnt antagonist genes in breast cancer. Br J Cancer 98:1147-1156
-
(2008)
Br J Cancer
, vol.98
, pp. 1147-1156
-
-
Suzuki, H.1
Toyota, M.2
Carraway, H.3
-
42
-
-
78651431471
-
Loss of Klotho during melanoma progression leads to increased filamin cleavage, increased Wnt5A expression, and enhanced melanoma cell motility
-
20955350 1:CAS:528:DC%2BC3MXisVCmurw%3D
-
Camilli TC, Xu M, O'Connell MP et al (2011) Loss of Klotho during melanoma progression leads to increased filamin cleavage, increased Wnt5A expression, and enhanced melanoma cell motility. Pigment Cell Melanoma Res 24:175-186
-
(2011)
Pigment Cell Melanoma Res
, vol.24
, pp. 175-186
-
-
Camilli, T.C.1
Xu, M.2
O'Connell, M.P.3
-
43
-
-
34547908461
-
Augmented Wnt signaling in a mammalian model of accelerated aging
-
17690294 1:CAS:528:DC%2BD2sXptVWjt7s%3D
-
Liu H, Fergusson MM, Castilho RM et al (2007) Augmented Wnt signaling in a mammalian model of accelerated aging. Science 317:803-806
-
(2007)
Science
, vol.317
, pp. 803-806
-
-
Liu, H.1
Fergusson, M.M.2
Castilho, R.M.3
-
44
-
-
33748850636
-
Activation of the canonical Wnt pathway leads to loss of hematopoietic stem cell repopulation and multilineage differentiation block
-
16951689 1:CAS:528:DC%2BD28Xps1yntbg%3D
-
Kirstetter P, Anderson K, Porse BT, Jacobsen SE, Nerlov C (2006) Activation of the canonical Wnt pathway leads to loss of hematopoietic stem cell repopulation and multilineage differentiation block. Nat Immunol 7:1048-1056
-
(2006)
Nat Immunol
, vol.7
, pp. 1048-1056
-
-
Kirstetter, P.1
Anderson, K.2
Porse, B.T.3
Jacobsen, S.E.4
Nerlov, C.5
-
45
-
-
43049144313
-
Wnt signaling and stem cell control
-
18392048 1:CAS:528:DC%2BD1cXltlSmsL8%3D
-
Nusse R (2008) Wnt signaling and stem cell control. Cell Res 18:523-527
-
(2008)
Cell Res
, vol.18
, pp. 523-527
-
-
Nusse, R.1
-
46
-
-
69249206717
-
MTOR mediates Wnt-induced epidermal stem cell exhaustion and aging
-
Castilho RM, Squarize CH, Chodosh LA, Williams BO, Gutkind JS (2009) mTOR mediates Wnt-induced epidermal stem cell exhaustion and aging. Cell Stem Cell 4:279-289
-
(2009)
Cell Stem Cell
, vol.4
, pp. 279-289
-
-
Castilho, R.M.1
Squarize, C.H.2
Chodosh, L.A.3
Williams, B.O.4
Gutkind, J.S.5
-
47
-
-
33748859509
-
Hematopoietic stem cell and multilineage defects generated by constitutive beta-catenin activation
-
16951686 1:CAS:528:DC%2BD28Xps1ynurw%3D
-
Scheller M, Huelsken J, Rosenbauer F et al (2006) Hematopoietic stem cell and multilineage defects generated by constitutive beta-catenin activation. Nat Immunol 7:1037-1047
-
(2006)
Nat Immunol
, vol.7
, pp. 1037-1047
-
-
Scheller, M.1
Huelsken, J.2
Rosenbauer, F.3
-
48
-
-
57749190558
-
Current understanding of klotho
-
19022406
-
Wang Y, Sun Z (2009) Current understanding of klotho. Ageing Res Rev 8:43-51
-
(2009)
Ageing Res Rev
, vol.8
, pp. 43-51
-
-
Wang, Y.1
Sun, Z.2
-
49
-
-
33646698671
-
Hydrogen peroxide: A signaling messenger
-
16677071 1:CAS:528:DC%2BD28Xkt12qs78%3D
-
Stone JR, Yang S (2006) Hydrogen peroxide: a signaling messenger. Antioxid Redox Signal 8:243-270
-
(2006)
Antioxid Redox Signal
, vol.8
, pp. 243-270
-
-
Stone, J.R.1
Yang, S.2
-
50
-
-
0035966052
-
Hydrogen peroxide generated during cellular insulin stimulation is integral to activation of the distal insulin signaling cascade in 3T3-L1 adipocytes
-
11598110 1:CAS:528:DC%2BD38Xktlaqtg%3D%3D
-
Mahadev K, Wu X, Zilbering A et al (2001) Hydrogen peroxide generated during cellular insulin stimulation is integral to activation of the distal insulin signaling cascade in 3T3-L1 adipocytes. J Biol Chem 276:48662-48669
-
(2001)
J Biol Chem
, vol.276
, pp. 48662-48669
-
-
Mahadev, K.1
Wu, X.2
Zilbering, A.3
-
51
-
-
0036479214
-
Reactive oxygen species as downstream mediators of angiogenic signaling by vascular endothelial growth factor receptor-2/KDR
-
11719508 1:CAS:528:DC%2BD38XhtVaksro%3D
-
Colavitti R, Pani G, Bedogni B et al (2002) Reactive oxygen species as downstream mediators of angiogenic signaling by vascular endothelial growth factor receptor-2/KDR. J Biol Chem 277:3101-3108
-
(2002)
J Biol Chem
, vol.277
, pp. 3101-3108
-
-
Colavitti, R.1
Pani, G.2
Bedogni, B.3
-
52
-
-
70349659193
-
Klotho gene delivery prevents the progression of spontaneous hypertension and renal damage
-
19635988 1:CAS:528:DC%2BD1MXhtFSns7rO
-
Wang Y, Sun Z (2009) Klotho gene delivery prevents the progression of spontaneous hypertension and renal damage. Hypertension 54:810-817
-
(2009)
Hypertension
, vol.54
, pp. 810-817
-
-
Wang, Y.1
Sun, Z.2
-
53
-
-
23944483457
-
Oxidative stress decreases klotho expression in a mouse kidney cell line
-
Mitobe M, Yoshida T, Sugiura H et al (2005) Oxidative stress decreases klotho expression in a mouse kidney cell line. Nephron Exp Nephrol 101:67-74
-
(2005)
Nephron Exp Nephrol
, vol.101
, pp. 67-74
-
-
Mitobe, M.1
Yoshida, T.2
Sugiura, H.3
-
54
-
-
40149102029
-
Klotho as a regulator of oxidative stress and senescence
-
18177265 1:CAS:528:DC%2BD1cXivFeqtb0%3D
-
Kuro-o M (2008) Klotho as a regulator of oxidative stress and senescence. Biol Chem 389:233-241
-
(2008)
Biol Chem
, vol.389
, pp. 233-241
-
-
Kuro-O, M.1
-
55
-
-
44449126104
-
Reactive oxygen species (ROS) in multistage carcinogenesis
-
18359554 1:CAS:528:DC%2BD1cXmsFKlu7Y%3D
-
Panayiotidis M (2008) Reactive oxygen species (ROS) in multistage carcinogenesis. Cancer Lett 266:3-5
-
(2008)
Cancer Lett
, vol.266
, pp. 3-5
-
-
Panayiotidis, M.1
-
56
-
-
5644284546
-
Serum withdrawal kills U937 cells by inducing a positive mutual interaction between reactive oxygen species and phosphoinositide 3-kinase
-
15494211 1:CAS:528:DC%2BD2cXos1eqsLo%3D
-
Lee SB, Cho ES, Yang HS, Kim H, Um HD (2005) Serum withdrawal kills U937 cells by inducing a positive mutual interaction between reactive oxygen species and phosphoinositide 3-kinase. Cell Signal 17:197-204
-
(2005)
Cell Signal
, vol.17
, pp. 197-204
-
-
Lee, S.B.1
Cho, E.S.2
Yang, H.S.3
Kim, H.4
Um, H.D.5
-
57
-
-
33749234968
-
DLPC and SAMe prevent alpha1(I) collagen mRNA up-regulation in human hepatic stellate cells, whether caused by leptin or menadione
-
16996477 1:CAS:528:DC%2BD28XhtVagtr7O
-
Cao Q, Mak KM, Lieber CS (2006) DLPC and SAMe prevent alpha1(I) collagen mRNA up-regulation in human hepatic stellate cells, whether caused by leptin or menadione. Biochem Biophys Res Commun 350:50-55
-
(2006)
Biochem Biophys Res Commun
, vol.350
, pp. 50-55
-
-
Cao, Q.1
Mak, K.M.2
Lieber, C.S.3
-
58
-
-
18044364401
-
Differential modulation of normal and tumor cell proliferation by reactive oxygen species
-
15862711 1:CAS:528:DC%2BD2MXjs1Kmt78%3D
-
Nicco C, Laurent A, Chereau C, Weill B, Batteux F (2005) Differential modulation of normal and tumor cell proliferation by reactive oxygen species. Biomed Pharmacother 59:169-174
-
(2005)
Biomed Pharmacother
, vol.59
, pp. 169-174
-
-
Nicco, C.1
Laurent, A.2
Chereau, C.3
Weill, B.4
Batteux, F.5
-
59
-
-
34248396033
-
Dual role of hydrogen peroxide in cancer: Possible relevance to cancer chemoprevention and therapy
-
17150302
-
López-Lázaro M (2007) Dual role of hydrogen peroxide in cancer: possible relevance to cancer chemoprevention and therapy. Cancer Lett 252:1-8
-
(2007)
Cancer Lett
, vol.252
, pp. 1-8
-
-
López-Lázaro, M.1
-
60
-
-
53449090706
-
ROS-generating mitochondrial DNA mutations can regulate tumor cell metastasis"-a critical commentary
-
18789385 1:CAS:528:DC%2BD1cXht1KlsLfJ
-
Zielonka J, Kalyanaraman B (2008) "ROS-generating mitochondrial DNA mutations can regulate tumor cell metastasis"-a critical commentary. Free Radic Biol Med 45:1217-1219
-
(2008)
Free Radic Biol Med
, vol.45
, pp. 1217-1219
-
-
Zielonka, J.1
Kalyanaraman, B.2
-
61
-
-
34247186472
-
Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4
-
17347651 1:CAS:528:DC%2BD2sXjslOmtLs%3D
-
Scherz-Shouval R, Shvets E, Fass E et al (2007) Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4. EMBO J 26:1749-1760
-
(2007)
EMBO J
, vol.26
, pp. 1749-1760
-
-
Scherz-Shouval, R.1
Shvets, E.2
Fass, E.3
-
62
-
-
36849021043
-
Atg7-dependent autophagy promotes neuronal health, stress tolerance, and longevity but is dispensable for metamorphosis in Drosophila
-
18056421
-
Juhász G, Erdi B, Sass M, Neufeld TP (2007) Atg7-dependent autophagy promotes neuronal health, stress tolerance, and longevity but is dispensable for metamorphosis in Drosophila. Genes Dev 21:3061-3066
-
(2007)
Genes Dev
, vol.21
, pp. 3061-3066
-
-
Juhász, G.1
Erdi, B.2
Sass, M.3
Neufeld, T.P.4
-
63
-
-
11144245626
-
The role of autophagy during the early neonatal starvation period
-
15525940 1:CAS:528:DC%2BD2cXhtFeisrnJ
-
Kuma A, Hatano M, Matsui M et al (2004) The role of autophagy during the early neonatal starvation period. Nature 432:1032-1036
-
(2004)
Nature
, vol.432
, pp. 1032-1036
-
-
Kuma, A.1
Hatano, M.2
Matsui, M.3
-
64
-
-
0042691506
-
Autophagy genes are essential for dauer development and life-span extension in C. Elegans
-
12958363
-
Meléndez A, Tallóczy Z, Seaman M et al (2003) Autophagy genes are essential for dauer development and life-span extension in C. elegans. Science 301:1387-1391
-
(2003)
Science
, vol.301
, pp. 1387-1391
-
-
Meléndez, A.1
Tallóczy, Z.2
Seaman, M.3
-
65
-
-
27844561111
-
Regulation of oxidative stress by the anti-aging hormone klotho
-
16186101 1:CAS:528:DC%2BD2MXhtF2is7zM
-
Yamamoto M, Clark JD, Pastor JV et al (2005) Regulation of oxidative stress by the anti-aging hormone klotho. J Biol Chem 280:38029-38034
-
(2005)
J Biol Chem
, vol.280
, pp. 38029-38034
-
-
Yamamoto, M.1
Clark, J.D.2
Pastor, J.V.3
-
66
-
-
0142134263
-
Iron chelation and a free radical scavenger suppress angiotensin II-induced downregulation of klotho, an anti-aging gene, in rat
-
12965205 1:CAS:528:DC%2BD3sXntVCjs7k%3D
-
Saito K, Ishizaka N, Mitani H, Ohno M, Nagai R (2003) Iron chelation and a free radical scavenger suppress angiotensin II-induced downregulation of klotho, an anti-aging gene, in rat. FEBS Lett 551:58-62
-
(2003)
FEBS Lett
, vol.551
, pp. 58-62
-
-
Saito, K.1
Ishizaka, N.2
Mitani, H.3
Ohno, M.4
Nagai, R.5
-
67
-
-
77957341040
-
Reactive oxygen species and age-related genes p66shc, Sirtuin, FOX03 and Klotho in senescence
-
20716932
-
Afanas'ev I (2010) Reactive oxygen species and age-related genes p66shc, Sirtuin, FOX03 and Klotho in senescence. Oxid Med Cell Longev 3:77-85
-
(2010)
Oxid Med Cell Longev
, vol.3
, pp. 77-85
-
-
Afanas'Ev, I.1
-
68
-
-
57749195944
-
Insulin exhibits short-term anti-inflammatory but long-term proinflammatory effects in vitro
-
18955107 1:CAS:528:DC%2BD1cXhsFCms7nE
-
Iwasaki Y, Nishiyama M, Taguchi T et al (2009) Insulin exhibits short-term anti-inflammatory but long-term proinflammatory effects in vitro. Mol Cell Endocrinol 298:25-32
-
(2009)
Mol Cell Endocrinol
, vol.298
, pp. 25-32
-
-
Iwasaki, Y.1
Nishiyama, M.2
Taguchi, T.3
-
69
-
-
40949123149
-
Activation of innate immunity system during aging: NF-kB signaling is the molecular culprit of inflamm-aging
-
17964225 1:CAS:528:DC%2BD1cXmsVyksr0%3D
-
Salminen A, Huuskonen J, Ojala J et al (2008) Activation of innate immunity system during aging: NF-kB signaling is the molecular culprit of inflamm-aging. Ageing Res Rev 7:83-105
-
(2008)
Ageing Res Rev
, vol.7
, pp. 83-105
-
-
Salminen, A.1
Huuskonen, J.2
Ojala, J.3
-
70
-
-
65549139675
-
Regulation of the aging process by autophagy
-
19380253 1:CAS:528:DC%2BD1MXmtVWntL8%3D
-
Salminen A, Kaarniranta K (2009) Regulation of the aging process by autophagy. Trends Mol Med 15:217-224
-
(2009)
Trends Mol Med
, vol.15
, pp. 217-224
-
-
Salminen, A.1
Kaarniranta, K.2
-
71
-
-
62949091373
-
Autophagy: A lysosomal degradation pathway with a central role in health and disease
-
Eskelinen EL, Saftig P (2004) Autophagy: a lysosomal degradation pathway with a central role in health and disease. Biochim Biophys Acta 1793:664-673
-
(2004)
Biochim Biophys Acta
, vol.1793
, pp. 664-673
-
-
Eskelinen, E.L.1
Saftig, P.2
-
72
-
-
2442482810
-
Autophagy as a cell death and tumor suppressor mechanism
-
15077152 1:CAS:528:DC%2BD2cXivFKmsL8%3D
-
Gozuacik D, Kimchi A (2004) Autophagy as a cell death and tumor suppressor mechanism. Oncogene 23:2891-2906
-
(2004)
Oncogene
, vol.23
, pp. 2891-2906
-
-
Gozuacik, D.1
Kimchi, A.2
-
73
-
-
33746108329
-
Lysosomal turnover, but not a cellular level, of endogenous LC3 is a marker for autophagy
-
16874052 1:CAS:528:DC%2BD2MXhtVyktL7O
-
Tanida I, Minematsu-Ikeguchi N, Ueno T, Kominami E (2005) Lysosomal turnover, but not a cellular level, of endogenous LC3 is a marker for autophagy. Autophagy 1:84-91
-
(2005)
Autophagy
, vol.1
, pp. 84-91
-
-
Tanida, I.1
Minematsu-Ikeguchi, N.2
Ueno, T.3
Kominami, E.4
-
74
-
-
77951568703
-
Phosphoinositide signalling in cancer: Beyond PI3K and PTEN
-
20414202 1:CAS:528:DC%2BC3cXltV2ktb4%3D
-
Bunney TD, Katan M (2010) Phosphoinositide signalling in cancer: beyond PI3K and PTEN. Nat Rev Cancer 10:342-352
-
(2010)
Nat Rev Cancer
, vol.10
, pp. 342-352
-
-
Bunney, T.D.1
Katan, M.2
-
75
-
-
59749091850
-
A complex interplay between Akt, TSC2 and the two mTOR complexes
-
19143635 1:CAS:528:DC%2BD1MXotVWlsg%3D%3D
-
Huang J, Manning BD (2009) A complex interplay between Akt, TSC2 and the two mTOR complexes. Biochem Soc Trans 37:217-222
-
(2009)
Biochem Soc Trans
, vol.37
, pp. 217-222
-
-
Huang, J.1
Manning, B.D.2
-
76
-
-
53749104349
-
Akt inhibition promotes autophagy and sensitizes PTEN-null tumors to lysosomotropic agents
-
18838554 1:CAS:528:DC%2BD1cXht1Cht77K
-
Degtyarev M, De Mazière A, Orr C et al (2008) Akt inhibition promotes autophagy and sensitizes PTEN-null tumors to lysosomotropic agents. J Cell Biol 183:101-116
-
(2008)
J Cell Biol
, vol.183
, pp. 101-116
-
-
Degtyarev, M.1
De Mazière, A.2
Orr, C.3
-
77
-
-
0035929650
-
The tumor suppressor PTEN positively regulates macroautophagy by inhibiting the phosphatidylinositol 3-kinase/protein kinase B pathway
-
11477064 1:CAS:528:DC%2BD3MXntFaitbo%3D
-
Arico S, Petiot A, Bauvy C et al (2001) The tumor suppressor PTEN positively regulates macroautophagy by inhibiting the phosphatidylinositol 3-kinase/protein kinase B pathway. J Biol Chem 276:35243-35246
-
(2001)
J Biol Chem
, vol.276
, pp. 35243-35246
-
-
Arico, S.1
Petiot, A.2
Bauvy, C.3
-
78
-
-
36448940798
-
FoxO3 controls autophagy in skeletal muscle in vivo
-
18054315 1:CAS:528:DC%2BD2sXhsVektb%2FN
-
Mammucari C, Milan G, Romanello V et al (2007) FoxO3 controls autophagy in skeletal muscle in vivo. Cell Metab 6:458-471
-
(2007)
Cell Metab
, vol.6
, pp. 458-471
-
-
Mammucari, C.1
Milan, G.2
Romanello, V.3
-
79
-
-
78651300628
-
Autophagic-lysosomal pathway functions in the masseter and tongue muscles in the klotho mouse, a mouse model for aging
-
21082218 1:CAS:528:DC%2BC3MXis1akug%3D%3D
-
Iida RH, Kanko S, Suga T, Morito M, Yamane A (2011) Autophagic-lysosomal pathway functions in the masseter and tongue muscles in the klotho mouse, a mouse model for aging. Mol Cell Biochem 348:89-98
-
(2011)
Mol Cell Biochem
, vol.348
, pp. 89-98
-
-
Iida, R.H.1
Kanko, S.2
Suga, T.3
Morito, M.4
Yamane, A.5
|