Epigenetic silencing of the tumor suppressor klotho in human breast cancer

Breast Cancer Research and Treatment

Volumn 133, Issue 2, 2012, Pages 649-657

  Rubinek, Tami ^a   Shulman, Michal ^a   Israeli, Shira ^a   Bose, Shikha ^b   Avraham, Ayelet ^c   Zundelevich, Adi ^a   Evron, Ella ^c,d   Gal Yam, Einav Nili ^a   Kaufman, Bella ^a   Wolf, Ido ^a,d  

^a SHEBA MEDICAL CENTER   (Israel)

^b CEDARS SINAI MEDICAL CENTER   (United States)

^c ASSAF HAROFEH MEDICAL CENTER   (Israel)

^d TEL AVIV UNIVERSITY   (Israel)

Author keywords

Breast cancer; Histone acetylation; Klotho; Methylation

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; KLOTHO PROTEIN; VORINOSTAT;

ARTICLE; ATYPICAL DUCTAL HYPERPLASIA; BREAST CANCER; CARCINOGENESIS; CHROMATIN IMMUNOPRECIPITATION; CLINICAL ARTICLE; CONTROLLED STUDY; DEACETYLATION; DNA METHYLATION; ENZYME ACTIVITY; EPIGENETICS; GENE EXPRESSION; GENE SILENCING; HISTONE ACETYLATION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; KLOTHO GENE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; TUMOR SUPPRESSOR GENE;

ACETYLATION; AZACITIDINE; BASE SEQUENCE; BREAST; BREAST NEOPLASMS; CELL LINE, TUMOR; CPG ISLANDS; DNA METHYLATION; FEMALE; GENE SILENCING; GLUCURONIDASE; HISTONES; HUMANS; PROMOTER REGIONS, GENETIC; TUMOR SUPPRESSOR PROTEINS;

EID: 84863726107     PISSN: 01676806     EISSN: 15737217     Source Type: Journal    
DOI: 10.1007/s10549-011-1824-4     Document Type: Article

References (36)

1. Kuro-o M, Matsumura Y, Aizawa H, Kawaguchi H, Suga T, Utsugi T, Ohyama Y, Kurabayashi M, Kaname T, Kume E et al (1997) Mutation of the mouse klotho gene leads to a syndrome resembling ageing. Nature 390:45-51
2. Kurosu H, Yamamoto M, Clark JD, Pastor JV, Nandi A, Gurnani P, McGuinness OP, Chikuda H, Yamaguchi M, Kawaguchi H et al (2005) Suppression of aging in mice by the hormone Klotho. Science 309:1829-1833
3. Ito S, Kinoshita S, Shiraishi N, Nakagawa S, Sekine S, Fujimori T, Nabeshima Y (2000) Molecular cloning and expression analyses of mouse [beta]klotho, which encodes a novel Klotho family protein. Mech Develop 98:115-119
4. Matsumura Y, Aizawa H, Shiraki-Iida T, Nagai R, Kuro-o M, Nabeshima Y (1998) Identification of the human klotho gene and its two transcripts encoding membrane and secreted klotho protein. Biochem Biophys Res Commun 242:626-630
5. Shiraki-Iida T, Aizawa H, Matsumura Y, Sekine S, Iida A, Anazawa H, Nagai R, Kuro-o M, Nabeshima Y (1998) Structure of the mouse klotho gene and its two transcripts encoding membrane and secreted protein. FEBS Letters 424:6-10
6. Imura A, Iwano A, Tohyama O, Tsuji Y, Nozaki K, Hashimoto N, Fujimori T, Nabeshima Y (2004) Secreted Klotho protein in sera and CSF: implication for post-translational cleavage in release of Klotho protein from cell membrane. FEBS Letters 565:143-147
7. Chen C-D, Podvin S, Gillespie E, Leeman SE, Abraham CR (2007) Insulin stimulates the cleavage and release of the extra cellular domain of Klotho by ADAM10 and ADAM17. Proc Natl Acad Sci 104:19796-19801
8. Ohyama Y, Kurabayashi M, Masuda H, Nakamura T, Aihara Y, Kaname T, Suga T, Arai M, Aizawa H, Matsumura Y et al (1998) Molecular cloning of rat klotho cDNA: markedly decreased expression of klotho by acute inflammatory stress. Biochem Biophys Res Commun 251:920-925
9. Cha S-K, Ortega B, Kurosu H, Rosenblatt KP, Kuro-o M, Huang C-L (2008) Removal of sialic acid involving Klotho causes cell-surface retention of TRPV5 channel via binding to galectin-1. Proc Natl Acad Sci 105:9805-9810
10. Kurosu H, Ogawa Y, Miyoshi M, Yamamoto M, Nandi A, Rosenblatt KP, Baum MG, Schiavi S, Hu M-C, Moe OW et al (2006) Regulation of fibroblast growth factor-23 signaling by Klotho. J Biol Chem 281:6120-6123
11. Urakawa I, Yamazaki Y, Shimada T, Iijima K, Hasegawa H, Okawa K, Fujita T, Fukumoto S, Yamashita T (2006) Klotho converts canonical FGF receptor into a specific receptor for FGF23. Nature 444:770-774
12. Wolf I, Sadetzki S, Catane R, Karasik A, Kaufman B (2005) Diabetes mellitus and breast cancer. Lancet Oncol 6:103-111
13. Yee D (2006) Targeting insulin-like growth factor pathways. Br J Cancer 94:465-468
14. Wolf I, Levanon-Cohen S, Bose S, Ligumsky H, Sredni B, Kanety H, Kuro-o M, Karlan B, Kaufman B, Koeffler HP et al (2008) Klotho: a tumor suppressor and a modulator of the IGF-1 and FGF pathways in human breast cancer. Oncogene 27:7094-7105
15. Wolf I, Laitman Y, Rubinek T, Abramovitz L, Novikov I, Beeri R, Kuro OM, Koeffler HP, Catane R, Freedman LS et al (2010) Functional variant of KLOTHO: a breast cancer risk modifier among BRCA1 mutation carriers of Ashkenazi origin. Oncogene 29:26-33
16. Chen B, Wang X, Zhao W, Wu J (2010) Klotho inhibits growth and promotes apoptosis in human lung cancer cell line A549. J Exp Clin Cancer Res 29:99
17. Doi S, Zou Y, Togao O, Pastor JV, John GB, Wang L, Shiizaki K, Gotschall R, Schiavi S, Yorioka N et al (2011) Klotho inhibits transforming growth factor-{beta}1 (TGF-{beta}1) signaling and suppresses renal fibrosis and cancer metastasis in mice. J Biol Chem 286:8655-8665
18. Lee J, Jeong D-J, Kim J, Lee S, Park J-H, Chang B, Jung S-I, Yi L, Han Y, Yang Y et al (2010) The anti-aging gene KLOTHO is a novel target for epigenetic silencing in human cervical carcinoma. Molecular Cancer 9:109-119
19. Lu L, Katsaros D, Wiley A, de la Longrais IA, Puopolo M, Yu H (2008) Klotho expression in epithelial ovarian cancer and its association with insulin-like growth factors and disease progression. Cancer Invest 26:185-192
20. Wang X, Chen B, Xu W, Liu S, Zhao W, Wu J (2011) Combined effects of klotho and soluble CD40 ligand on A549 lung cancer cells. Oncol Rep 25(5):1465-1472
21. Sharma S, Kelly TK, Jones PA (2010) Epigenetics in cancer. Carcinogenesis 31:27-36
22. Lo P-K, Sukumar S (2008) Epigenomics and breast cancer. Pharmacogenomics 9:1879-1902
23. Wolf I, Bose S, Desmond J, Lin B, Williamson E, Karlan B, Koeffler H (2007) Unmasking of epigenetically silenced genes reveals DNA promoter methylation and reduced expression of PTCH in breast cancer. Breast Cancer Res Treat 105:139-155
24. Wolf I, Bose S, Williamson EA, Miller CW, Karlan BY, Koeffler HP (2007) FOXA1: Growth inhibitor and a favorable prognostic factor in human breast cancer. Int J Cancer 120:1013-1022
25. McShane L, Altman D, Sauerbrei W, Taube S, Gion M, Clark G (2006) REporting recommendations for tumor MARKer prognostic studies (REMARK). Breast Cancer Res Treat 100:229-235
26. Gal-Yam EN, Egger G, Iniguez L, Holster H, Einarsson Sm, Zhang X, Lin JC, Liang G, Jones PA, Tanay A (2008) Frequent switching of Polycomb repressive marks and DNA hypermethy-lation in the PC3 prostate cancer cell line. Proc Natl Acad Sci 105:12979-12984
27. Lacroix M, Leclercq G (2004) Relevance of breast cancer cell lines as models for breast tumours: an update. Breast Cancer Res Treat 83:249-289
28. Wolf I, O'Kelly J, Rubinek T, Tong M, Nguyen A, Lin BT, Tai H-H, Karlan BY, Koeffler HP (2006) 15-Hydroxyprostaglandin dehydrogenase is a tumor suppressor of human breast cancer. Cancer Res 66:7818-7823
29. Richon VM, Emiliani S, Verdin E, Webb Y, Breslow R, Rifkind RA, Marks PA (1998) A class of hybrid polar inducers of transformed cell differentiation inhibits histone deacetylases. Proc Natl Acad Sci 95:3003-3007
30. Schnitt SJ (2003) Benign breast disease and breast cancer risk: morphology and beyond. Am J Surg Pathol 27:836-841
31. Hoque MO, Prencipe M, Poeta ML, Barbano R, Valori VM, Copetti M, Gallo AP, Brait M, Maiello E, Apicella A et al (2009) Changes in CpG islands promoter methylation patterns during ductal breast carcinoma progression. Cancer Epidem Biomar 18:2694-2700
32. Herman JG, Merlo A, Mao L, Lapidus RG, Issa J-PJ, Davidson NE, Sidransky D, Baylin SB (1995) Inactivation of the CDKN2/p16/MTS1 gene is frequently associated with aberrant DNA methylation in all common human cancers. Cancer Res 55:4525-4530
33. 0 regulatory region of the BRCA1 gene is tumor specific and includes a putative CREB binding site. Oncogene 16:1161-1169
34. Schutte M, Rozenblum E, Moskaluk CA, Guan X, Hoque AT, Hahn SA, da Costa LT, de Jong PJ, Kern SE (1995) An integrated high-resolution physical map of the DPC/BRCA2 region at chromosome 13q12. Cancer Res 55:4570-4574
35. Geck P, Maffini MV, Szelei J, Sonnenschein C, Soto AM (2000) Androgen-induced proliferative quiescence in prostate cancer cells: the role of AS3 as its mediator. Proc Natl Acad Sci 97:10185-10190
36. Schott DR, Chang JN, Deng G, Kurisu W, Kuo WL, Gray J, Smith HS (1994) A candidate tumor suppressor gene in human breast cancers. Cancer Res 54:1393-1396