-
1
-
-
0030724491
-
Mutation of the mouse klotho gene leads to a syndrome resembling ageing
-
Kuro-o M., Matsumura Y., Aizawa H., et al. Mutation of the mouse klotho gene leads to a syndrome resembling ageing. Nature 390 (1997) 45-51
-
(1997)
Nature
, vol.390
, pp. 45-51
-
-
Kuro-o, M.1
Matsumura, Y.2
Aizawa, H.3
-
2
-
-
24944481544
-
Suppression of aging in mice by the hormone Klotho
-
Kurosu H., Yamamoto M., Clark J.D., et al. Suppression of aging in mice by the hormone Klotho. Science 309 (2005) 1829-1833
-
(2005)
Science
, vol.309
, pp. 1829-1833
-
-
Kurosu, H.1
Yamamoto, M.2
Clark, J.D.3
-
3
-
-
14844345016
-
Association between a functional variant of the KLOTHO gene and high-density lipoprotein cholesterol, blood pressure, stroke, and longevity
-
Arking D.E., Atzmon G., Arking A., et al. Association between a functional variant of the KLOTHO gene and high-density lipoprotein cholesterol, blood pressure, stroke, and longevity. Circ Res 96 (2005) 412-418
-
(2005)
Circ Res
, vol.96
, pp. 412-418
-
-
Arking, D.E.1
Atzmon, G.2
Arking, A.3
-
4
-
-
0036785320
-
Klotho gene polymorphisms associated with bone density of aged postmenopausal women
-
Kawano K., Ogata N., Chiano M., et al. Klotho gene polymorphisms associated with bone density of aged postmenopausal women. J Bone Miner Res 17 (2002) 1744-1751
-
(2002)
J Bone Miner Res
, vol.17
, pp. 1744-1751
-
-
Kawano, K.1
Ogata, N.2
Chiano, M.3
-
6
-
-
12844263399
-
Association of polymorphisms of the androgen receptor and klotho genes with bone mineral density in Japanese women
-
Yamada Y., Ando F., Niino N., et al. Association of polymorphisms of the androgen receptor and klotho genes with bone mineral density in Japanese women. J Mol Med 83 (2005) 50-57
-
(2005)
J Mol Med
, vol.83
, pp. 50-57
-
-
Yamada, Y.1
Ando, F.2
Niino, N.3
-
7
-
-
0036309298
-
Association of klotho gene polymorphism with bone density and spondylosis of the lumbar spine in postmenopausal women
-
Ogata N., Matsumura Y., Shiraki M., et al. Association of klotho gene polymorphism with bone density and spondylosis of the lumbar spine in postmenopausal women. Bone 31 (2002) 37-42
-
(2002)
Bone
, vol.31
, pp. 37-42
-
-
Ogata, N.1
Matsumura, Y.2
Shiraki, M.3
-
8
-
-
27644533791
-
Klotho gene polymorphisms are associated with osteocalcin levels but not bone density of aged postmenopausal women
-
Mullin B.H., Wilson S.G., Islam F.M., et al. Klotho gene polymorphisms are associated with osteocalcin levels but not bone density of aged postmenopausal women. Calcif Tissue Int 77 (2005) 145-151
-
(2005)
Calcif Tissue Int
, vol.77
, pp. 145-151
-
-
Mullin, B.H.1
Wilson, S.G.2
Islam, F.M.3
-
9
-
-
22044456541
-
Association of klotho, bone morphogenic protein 6, and annexin A2 polymorphisms with sickle cell osteonecrosis
-
Baldwin C., Nolan V.G., Wyszynski D.F., et al. Association of klotho, bone morphogenic protein 6, and annexin A2 polymorphisms with sickle cell osteonecrosis. Blood 106 (2005) 372-375
-
(2005)
Blood
, vol.106
, pp. 372-375
-
-
Baldwin, C.1
Nolan, V.G.2
Wyszynski, D.F.3
-
10
-
-
33748741795
-
Klotho is a genetic risk factor for ischemic stroke caused by cardioembolism in Korean females
-
Kim Y., Kim J.H., Nam Y.J., et al. Klotho is a genetic risk factor for ischemic stroke caused by cardioembolism in Korean females. Neurosci Lett 407 (2006) 189-194
-
(2006)
Neurosci Lett
, vol.407
, pp. 189-194
-
-
Kim, Y.1
Kim, J.H.2
Nam, Y.J.3
-
11
-
-
0038744264
-
KLOTHO allele status and the risk of early-onset occult coronary artery disease
-
Arking D.E., Becker D.M., Yanek L.R., et al. KLOTHO allele status and the risk of early-onset occult coronary artery disease. Am J Hum Genet 72 (2003) 1154-1161
-
(2003)
Am J Hum Genet
, vol.72
, pp. 1154-1161
-
-
Arking, D.E.1
Becker, D.M.2
Yanek, L.R.3
-
12
-
-
33746704926
-
Klotho gene polymorphism may be a genetic risk factor for atherosclerotic coronary artery disease but not for vasospastic angina in Japanese
-
Imamura A., Okumura K., Ogawa Y., et al. Klotho gene polymorphism may be a genetic risk factor for atherosclerotic coronary artery disease but not for vasospastic angina in Japanese. Clin Chim Acta 371 (2006) 66-70
-
(2006)
Clin Chim Acta
, vol.371
, pp. 66-70
-
-
Imamura, A.1
Okumura, K.2
Ogawa, Y.3
-
13
-
-
43749088566
-
A homozygous missense mutation in human KLOTHO causes severe tumoral calcinosis
-
Ichikawa S., Imel E.A., Kreiter M.L., et al. A homozygous missense mutation in human KLOTHO causes severe tumoral calcinosis. J Musculoskelet Neuronal Interact 7 (2007) 318-319
-
(2007)
J Musculoskelet Neuronal Interact
, vol.7
, pp. 318-319
-
-
Ichikawa, S.1
Imel, E.A.2
Kreiter, M.L.3
-
14
-
-
42149130855
-
A translocation causing increased alpha-klotho level results in hypophosphatemic rickets and hyperparathyroidism
-
Brownstein C.A., Adler F., Nelson-Williams C., et al. A translocation causing increased alpha-klotho level results in hypophosphatemic rickets and hyperparathyroidism. Proc Natl Acad Sci U S A 105 (2008) 3455-3460
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, pp. 3455-3460
-
-
Brownstein, C.A.1
Adler, F.2
Nelson-Williams, C.3
-
15
-
-
0032567647
-
Identification of the human klotho gene and its two transcripts encoding membrane and secreted klotho protein
-
Matsumura Y., Aizawa H., Shiraki-Iida T., et al. Identification of the human klotho gene and its two transcripts encoding membrane and secreted klotho protein. Biochem Biophys Res Commun 242 (1998) 626-630
-
(1998)
Biochem Biophys Res Commun
, vol.242
, pp. 626-630
-
-
Matsumura, Y.1
Aizawa, H.2
Shiraki-Iida, T.3
-
16
-
-
38049144010
-
Insulin stimulates the cleavage and release of the extracellular domain of Klotho by ADAM10 and ADAM17
-
Chen C.D., Podvin S., Gillespie E., et al. Insulin stimulates the cleavage and release of the extracellular domain of Klotho by ADAM10 and ADAM17. Proc Natl Acad Sci U S A 104 (2007) 19796-19801
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, pp. 19796-19801
-
-
Chen, C.D.1
Podvin, S.2
Gillespie, E.3
-
17
-
-
0034685014
-
Establishment of the anti-Klotho monoclonal antibodies and detection of Klotho protein in kidneys
-
Kato Y., Arakawa E., Kinoshita S., et al. Establishment of the anti-Klotho monoclonal antibodies and detection of Klotho protein in kidneys. Biochem Biophys Res Commun 267 (2000) 597-602
-
(2000)
Biochem Biophys Res Commun
, vol.267
, pp. 597-602
-
-
Kato, Y.1
Arakawa, E.2
Kinoshita, S.3
-
18
-
-
1642352496
-
Klotho is a novel beta-glucuronidase capable of hydrolyzing steroid beta-glucuronides
-
Tohyama O., Imura A., Iwano A., et al. Klotho is a novel beta-glucuronidase capable of hydrolyzing steroid beta-glucuronides. J Biol Chem 279 (2004) 9777-9784
-
(2004)
J Biol Chem
, vol.279
, pp. 9777-9784
-
-
Tohyama, O.1
Imura, A.2
Iwano, A.3
-
19
-
-
13844318061
-
Immunohistochemical localization of Klotho protein in brain, kidney, and reproductive organs of mice
-
Li S.A., Watanabe M., Yamada H., et al. Immunohistochemical localization of Klotho protein in brain, kidney, and reproductive organs of mice. Cell Struct Funct 29 (2004) 91-99
-
(2004)
Cell Struct Funct
, vol.29
, pp. 91-99
-
-
Li, S.A.1
Watanabe, M.2
Yamada, H.3
-
20
-
-
27144440831
-
The beta-glucuronidase klotho hydrolyzes and activates the TRPV5 channel
-
Chang Q., Hoefs S., van der Kemp A.W., et al. The beta-glucuronidase klotho hydrolyzes and activates the TRPV5 channel. Science 310 (2005) 490-493
-
(2005)
Science
, vol.310
, pp. 490-493
-
-
Chang, Q.1
Hoefs, S.2
van der Kemp, A.W.3
-
21
-
-
22244464849
-
Klotho protein activates the PKC pathway in the kidney and testis and suppresses 25-hydroxyvitamin D3 1alpha-hydroxylase gene expression
-
Imai M., Ishikawa K., Matsukawa N., et al. Klotho protein activates the PKC pathway in the kidney and testis and suppresses 25-hydroxyvitamin D3 1alpha-hydroxylase gene expression. Endocrine 25 (2004) 229-234
-
(2004)
Endocrine
, vol.25
, pp. 229-234
-
-
Imai, M.1
Ishikawa, K.2
Matsukawa, N.3
-
22
-
-
27844561111
-
Regulation of oxidative stress by the anti-aging hormone klotho
-
Yamamoto M., Clark J.D., Pastor J.V., et al. Regulation of oxidative stress by the anti-aging hormone klotho. J Biol Chem 280 (2005) 38029-38034
-
(2005)
J Biol Chem
, vol.280
, pp. 38029-38034
-
-
Yamamoto, M.1
Clark, J.D.2
Pastor, J.V.3
-
23
-
-
33646578195
-
Regulation of fibroblast growth factor-23 signaling by klotho
-
Kurosu H., Ogawa Y., Miyoshi M., et al. Regulation of fibroblast growth factor-23 signaling by klotho. J Biol Chem 281 (2006) 6120-6123
-
(2006)
J Biol Chem
, vol.281
, pp. 6120-6123
-
-
Kurosu, H.1
Ogawa, Y.2
Miyoshi, M.3
-
24
-
-
33845631059
-
Klotho converts canonical FGF receptor into a specific receptor for FGF23
-
Urakawa I., Yamazaki Y., Shimada T., et al. Klotho converts canonical FGF receptor into a specific receptor for FGF23. Nature 444 (2006) 770-774
-
(2006)
Nature
, vol.444
, pp. 770-774
-
-
Urakawa, I.1
Yamazaki, Y.2
Shimada, T.3
-
25
-
-
34250803923
-
alpha-Klotho as a regulator of calcium homeostasis
-
Imura A., Tsuji Y., Murata M., et al. alpha-Klotho as a regulator of calcium homeostasis. Science 316 (2007) 1615-1618
-
(2007)
Science
, vol.316
, pp. 1615-1618
-
-
Imura, A.1
Tsuji, Y.2
Murata, M.3
-
26
-
-
0032746021
-
Independent impairment of osteoblast and osteoclast differentiation in klotho mouse exhibiting low-turnover osteopenia
-
Kawaguchi H., Manabe N., Miyaura C., et al. Independent impairment of osteoblast and osteoclast differentiation in klotho mouse exhibiting low-turnover osteopenia. J Clin Invest 104 (1999) 229-237
-
(1999)
J Clin Invest
, vol.104
, pp. 229-237
-
-
Kawaguchi, H.1
Manabe, N.2
Miyaura, C.3
-
27
-
-
0034091390
-
Cellular and molecular mechanism of low-turnover osteopenia in the klotho-deficient mouse
-
Kawaguchi H., Manabe N., Chikuda H., et al. Cellular and molecular mechanism of low-turnover osteopenia in the klotho-deficient mouse. Cell Mol Life Sci 57 (2000) 731-737
-
(2000)
Cell Mol Life Sci
, vol.57
, pp. 731-737
-
-
Kawaguchi, H.1
Manabe, N.2
Chikuda, H.3
-
28
-
-
33947622052
-
Association of the F352V variant of the Klotho gene with bone mineral density
-
Riancho J.A., Valero C., Hernandez J.L., et al. Association of the F352V variant of the Klotho gene with bone mineral density. Biogerontology 8 (2007) 121-127
-
(2007)
Biogerontology
, vol.8
, pp. 121-127
-
-
Riancho, J.A.1
Valero, C.2
Hernandez, J.L.3
-
29
-
-
0035208924
-
The progression of aging in klotho mutant mice can be modified by dietary phosphorus and zinc
-
Morishita K., Shirai A., Kubota M., et al. The progression of aging in klotho mutant mice can be modified by dietary phosphorus and zinc. J Nutr 131 (2001) 3182-3188
-
(2001)
J Nutr
, vol.131
, pp. 3182-3188
-
-
Morishita, K.1
Shirai, A.2
Kubota, M.3
-
30
-
-
0346849707
-
Klotho, a gene related to a syndrome resembling human premature aging, functions in a negative regulatory circuit of vitamin D endocrine system
-
Tsujikawa H., Kurotaki Y., Fujimori T., et al. Klotho, a gene related to a syndrome resembling human premature aging, functions in a negative regulatory circuit of vitamin D endocrine system. Mol Endocrinol 17 (2003) 2393-2403
-
(2003)
Mol Endocrinol
, vol.17
, pp. 2393-2403
-
-
Tsujikawa, H.1
Kurotaki, Y.2
Fujimori, T.3
-
31
-
-
33646238028
-
Premature aging-like phenotype in fibroblast growth factor 23 null mice is a vitamin D-mediated process
-
Razzaque M.S., Sitara D., Taguchi T., et al. Premature aging-like phenotype in fibroblast growth factor 23 null mice is a vitamin D-mediated process. Faseb J 20 (2006) 720-722
-
(2006)
Faseb J
, vol.20
, pp. 720-722
-
-
Razzaque, M.S.1
Sitara, D.2
Taguchi, T.3
-
32
-
-
33746341155
-
Hypervitaminosis D and premature aging: lessons learned from Fgf23 and Klotho mutant mice
-
Razzaque M.S., and Lanske B. Hypervitaminosis D and premature aging: lessons learned from Fgf23 and Klotho mutant mice. Trends Mol Med 12 (2006) 298-305
-
(2006)
Trends Mol Med
, vol.12
, pp. 298-305
-
-
Razzaque, M.S.1
Lanske, B.2
-
33
-
-
28444440235
-
The epithelial Ca2+ channel TRPV5 is essential for proper osteoclastic bone resorption
-
van der Eerden B.C., Hoenderop J.G., et al. The epithelial Ca2+ channel TRPV5 is essential for proper osteoclastic bone resorption. Proc Natl Acad Sci U S A 102 (2005) 17507-17512
-
(2005)
Proc Natl Acad Sci U S A
, vol.102
, pp. 17507-17512
-
-
van der Eerden, B.C.1
Hoenderop, J.G.2
-
34
-
-
33846867744
-
Correlation between hyperphosphatemia and type II Na-Pi cotransporter activity in klotho mice
-
Segawa H., Yamanaka S., Ohno Y., et al. Correlation between hyperphosphatemia and type II Na-Pi cotransporter activity in klotho mice. Am J Physiol Renal Physiol 292 (2007) F769-F779
-
(2007)
Am J Physiol Renal Physiol
, vol.292
-
-
Segawa, H.1
Yamanaka, S.2
Ohno, Y.3
-
35
-
-
0027765508
-
Cloning and characterization of an extracellular Ca2+-sensing receptor from bovine parathyroid
-
Brown E., Gamba G., Riccardi D., et al. Cloning and characterization of an extracellular Ca2+-sensing receptor from bovine parathyroid. Nature 366 (1993) 575-580
-
(1993)
Nature
, vol.366
, pp. 575-580
-
-
Brown, E.1
Gamba, G.2
Riccardi, D.3
-
36
-
-
35848947037
-
Fibroblast growth factor-23 regulates parathyroid hormone and 1alpha-hydroxylase expression in cultured bovine parathyroid cells
-
Krajisnik T., Bjorklund P., Marsell R., et al. Fibroblast growth factor-23 regulates parathyroid hormone and 1alpha-hydroxylase expression in cultured bovine parathyroid cells. J Endocrinol 195 (2007) 125-131
-
(2007)
J Endocrinol
, vol.195
, pp. 125-131
-
-
Krajisnik, T.1
Bjorklund, P.2
Marsell, R.3
-
37
-
-
18244372958
-
Association of human aging with a functional variant of klotho
-
Arking D.E., Krebsova A., Macek Sr. M., et al. Association of human aging with a functional variant of klotho. Proc Natl Acad Sci U S A 99 (2002) 856-861
-
(2002)
Proc Natl Acad Sci U S A
, vol.99
, pp. 856-861
-
-
Arking, D.E.1
Krebsova, A.2
Macek Sr., M.3
-
38
-
-
2942536306
-
Klotho is a serum factor related to human aging
-
Xiao N.M., Zhang Y.M., Zheng Q., et al. Klotho is a serum factor related to human aging. Chin Med J (Engl) 117 (2004) 742-747
-
(2004)
Chin Med J (Engl)
, vol.117
, pp. 742-747
-
-
Xiao, N.M.1
Zhang, Y.M.2
Zheng, Q.3
-
40
-
-
28844474827
-
Anti-apoptotic and anti-senescence effects of Klotho on vascular endothelial cells
-
Ikushima M., Rakugi H., Ishikawa K., et al. Anti-apoptotic and anti-senescence effects of Klotho on vascular endothelial cells. Biochem Biophys Res Commun 339 (2006) 827-832
-
(2006)
Biochem Biophys Res Commun
, vol.339
, pp. 827-832
-
-
Ikushima, M.1
Rakugi, H.2
Ishikawa, K.3
-
41
-
-
0034130405
-
Endothelial dysfunction in the klotho mouse and downregulation of klotho gene expression in various animal models of vascular and metabolic diseases
-
Nagai R., Saito Y., Ohyama Y., et al. Endothelial dysfunction in the klotho mouse and downregulation of klotho gene expression in various animal models of vascular and metabolic diseases. Cell Mol Life Sci 57 (2000) 738-746
-
(2000)
Cell Mol Life Sci
, vol.57
, pp. 738-746
-
-
Nagai, R.1
Saito, Y.2
Ohyama, Y.3
-
43
-
-
0034710838
-
In vivo klotho gene delivery protects against endothelial dysfunction in multiple risk factor syndrome
-
Saito Y., Nakamura T., Ohyama Y., et al. In vivo klotho gene delivery protects against endothelial dysfunction in multiple risk factor syndrome. Biochem Biophys Res Commun 276 (2000) 767-772
-
(2000)
Biochem Biophys Res Commun
, vol.276
, pp. 767-772
-
-
Saito, Y.1
Nakamura, T.2
Ohyama, Y.3
-
44
-
-
30044451280
-
Klotho-induced insulin resistance: a blessing in disguise?
-
Unger R.H. Klotho-induced insulin resistance: a blessing in disguise?. Nat Med 12 (2006) 56-57
-
(2006)
Nat Med
, vol.12
, pp. 56-57
-
-
Unger, R.H.1
|