-
2
-
-
0030724491
-
Mutation of the mouse klotho gene leads to a syndrome resembling ageing
-
10.1038/36285. 9363890
-
Mutation of the mouse klotho gene leads to a syndrome resembling ageing. M Kuro-o Y Matsumura H Aizawa H Kawaguchi T Suga T Utsugi Y Ohyama M Kurabayashi T Kaname E Kume, et al. Nature 1997 390 45 51 10.1038/36285 9363890
-
(1997)
Nature
, vol.390
, pp. 45-51
-
-
Kuro-O, M.1
Matsumura, Y.2
Aizawa, H.3
Kawaguchi, H.4
Suga, T.5
Utsugi, T.6
Ohyama, Y.7
Kurabayashi, M.8
Kaname, T.9
Kume, E.10
-
3
-
-
24944481544
-
Suppression of aging in mice by the hormone Klotho
-
10.1126/science.1112766. 16123266
-
Suppression of aging in mice by the hormone Klotho. H Kurosu M Yamamoto JD Clark JV Pastor A Nandi P Gurnani OP McGuinness H Chikuda M Yamaguchi H Kawaguchi, et al. Science 2005 309 1829 1833 10.1126/science.1112766 16123266
-
(2005)
Science
, vol.309
, pp. 1829-1833
-
-
Kurosu, H.1
Yamamoto, M.2
Clark, J.D.3
Pastor, J.V.4
Nandi, A.5
Gurnani, P.6
McGuinness, O.P.7
Chikuda, H.8
Yamaguchi, M.9
Kawaguchi, H.10
-
4
-
-
0032567647
-
Identification of the human klotho gene and its two transcripts encoding membrane and secreted klotho protein
-
DOI 10.1006/bbrc.1997.8019
-
Identification of the human klotho gene and its two transcripts encoding membrane and secreted klotho protein. Y Matsumura H Aizawa T Shiraki-Iida R Nagai M Kuro-o Y Nabeshima, Biochem Biophys Res Commun 1998 242 626 630 10.1006/bbrc.1997.8019 9464267 (Pubitemid 28412578)
-
(1998)
Biochemical and Biophysical Research Communications
, vol.242
, Issue.3
, pp. 626-630
-
-
Matsumura, Y.1
Aizawa, H.2
Shiraki-Iida, T.3
Nagai, R.4
Kuro-O, M.5
Nabeshima, Y.-I.6
-
5
-
-
0032489424
-
Structure of the mouse klotho gene and its two transcripts encoding membrane and secreted protein
-
DOI 10.1016/S0014-5793(98)00127-6, PII S0014579398001276
-
Structure of the mouse klotho gene and its two transcripts encoding membrane and secreted protein. T Shiraki-Iida H Aizawa Y Matsumura S Sekine A Iida H Anazawa R Nagai M Kuro-o Y Nabeshima, FEBS Lett 1998 424 6 10 10.1016/S0014-5793(98)00127-6 9537505 (Pubitemid 28130341)
-
(1998)
FEBS Letters
, vol.424
, Issue.1-2
, pp. 6-10
-
-
Shiraki-Iida, T.1
Aizawa, H.2
Matsumura, Y.3
Sekine, S.4
Iida, A.5
Anazawa, H.6
Nagai, R.7
Kuro-O, M.8
Nabeshima, Y.-I.9
-
6
-
-
0031904682
-
Sequence, structural, functional, and phylogenetic analyses of three glycosidase families
-
9779294
-
Sequence, structural, functional, and phylogenetic analyses of three glycosidase families. IS Mian, Blood Cells Mol Dis 1998 24 83 100 9779294
-
(1998)
Blood Cells Mol Dis
, vol.24
, pp. 83-100
-
-
Mian, I.S.1
-
7
-
-
2342610541
-
Secreted Klotho protein in sera and CSF: Implication for post-translational cleavage in release of Klotho protein from cell membrane
-
10.1016/j.febslet.2004.03.090. 15135068
-
Secreted Klotho protein in sera and CSF: implication for post-translational cleavage in release of Klotho protein from cell membrane. A Imura A Iwano O Tohyama Y Tsuji K Nozaki N Hashimoto T Fujimori Y Nabeshima, FEBS Lett 2004 565 143 147 10.1016/j.febslet.2004.03.090 15135068
-
(2004)
FEBS Lett
, vol.565
, pp. 143-147
-
-
Imura, A.1
Iwano, A.2
Tohyama, O.3
Tsuji, Y.4
Nozaki, K.5
Hashimoto, N.6
Fujimori, T.7
Nabeshima, Y.8
-
8
-
-
0033812019
-
Decreased insulin production and increased insulin sensitivity in the klotho mutant mouse, a novel animal model for human aging
-
10.1053/meta.2000.8606. 11016890
-
Decreased insulin production and increased insulin sensitivity in the klotho mutant mouse, a novel animal model for human aging. T Utsugi T Ohno Y Ohyama T Uchiyama Y Saito Y Matsumura H Aizawa H Itoh M Kurabayashi S Kawazu, et al. Metabolism 2000 49 1118 1123 10.1053/meta.2000.8606 11016890
-
(2000)
Metabolism
, vol.49
, pp. 1118-1123
-
-
Utsugi, T.1
Ohno, T.2
Ohyama, Y.3
Uchiyama, T.4
Saito, Y.5
Matsumura, Y.6
Aizawa, H.7
Itoh, H.8
Kurabayashi, M.9
Kawazu, S.10
-
9
-
-
0037470501
-
The endocrine regulation of aging by insulin-like signals
-
10.1126/science.1081447. 12610294
-
The endocrine regulation of aging by insulin-like signals. M Tatar A Bartke A Antebi, Science 2003 299 1346 1351 10.1126/science.1081447 12610294
-
(2003)
Science
, vol.299
, pp. 1346-1351
-
-
Tatar, M.1
Bartke, A.2
Antebi, A.3
-
10
-
-
34547908461
-
Augmented Wnt signaling in a mammalian model of accelerated aging
-
10.1126/science.1143578. 17690294
-
Augmented Wnt signaling in a mammalian model of accelerated aging. H Liu MM Fergusson RM Castilho J Liu L Cao J Chen D Malide II Rovira D Schimel CJ Kuo, et al. Science 2007 317 803 806 10.1126/science.1143578 17690294
-
(2007)
Science
, vol.317
, pp. 803-806
-
-
Liu, H.1
Fergusson, M.M.2
Castilho, R.M.3
Liu, J.4
Cao, L.5
Chen, J.6
Malide, D.7
Rovira, I.I.8
Schimel, D.9
Kuo, C.J.10
-
11
-
-
34250675360
-
Emerging role of fibroblast growth factor 23 in a bone-kidney axis regulating systemic phosphate homeostasis and extracellular matrix mineralization
-
10.1097/MNH.0b013e3281ca6ffd. 17565275
-
Emerging role of fibroblast growth factor 23 in a bone-kidney axis regulating systemic phosphate homeostasis and extracellular matrix mineralization. S Liu A Gupta LD Quarles, Curr Opin Nephrol Hypertens 2007 16 329 335 10.1097/MNH.0b013e3281ca6ffd 17565275
-
(2007)
Curr Opin Nephrol Hypertens
, vol.16
, pp. 329-335
-
-
Liu, S.1
Gupta, A.2
Quarles, L.D.3
-
12
-
-
0036235099
-
In vivo klotho gene transfer ameliorates angiotensin II-induced renal damage
-
10.1161/01.HYP.0000013734.33441.EA. 11967236
-
In vivo klotho gene transfer ameliorates angiotensin II-induced renal damage. H Mitani N Ishizaka T Aizawa M Ohno S Usui T Suzuki T Amaki I Mori Y Nakamura M Sato, et al. Hypertension 2002 39 838 843 10.1161/01.HYP.0000013734. 33441.EA 11967236
-
(2002)
Hypertension
, vol.39
, pp. 838-843
-
-
Mitani, H.1
Ishizaka, N.2
Aizawa, T.3
Ohno, M.4
Usui, S.5
Suzuki, T.6
Amaki, T.7
Mori, I.8
Nakamura, Y.9
Sato, M.10
-
13
-
-
0034710838
-
In vivo klotho gene delivery protects against endothelial dysfunction in multiple risk factor syndrome
-
10.1006/bbrc.2000.3470. 11027545
-
In vivo klotho gene delivery protects against endothelial dysfunction in multiple risk factor syndrome. Y Saito T Nakamura Y Ohyama T Suzuki A Iida T Shiraki-Iida M Kuro-o Y Nabeshima M Kurabayashi R Nagai, Biochem Biophys Res Commun 2000 276 767 772 10.1006/bbrc.2000.3470 11027545
-
(2000)
Biochem Biophys Res Commun
, vol.276
, pp. 767-772
-
-
Saito, Y.1
Nakamura, T.2
Ohyama, Y.3
Suzuki, T.4
Iida, A.5
Shiraki-Iida, T.6
Kuro-O, M.7
Nabeshima, Y.8
Kurabayashi, M.9
Nagai, R.10
-
14
-
-
23044493251
-
Blocking the insulin-like growth factor-I receptor as a strategy for targeting cancer
-
10.1016/S1359-6446(05)03512-9. 16055020
-
Blocking the insulin-like growth factor-I receptor as a strategy for targeting cancer. F Hofmann C García-Echeverría, Drug Discov Today 2005 10 1041 1047 10.1016/S1359-6446(05)03512-9 16055020
-
(2005)
Drug Discov Today
, vol.10
, pp. 1041-1047
-
-
Hofmann, F.1
García-Echeverría, C.2
-
15
-
-
35148837581
-
Mechanisms of disease: Signaling of the insulin-like growth factor 1 receptor pathway-therapeutic perspectives in cancer
-
10.1038/ncponc0934. 17898809
-
Mechanisms of disease: signaling of the insulin-like growth factor 1 receptor pathway-therapeutic perspectives in cancer. Y Tao V Pinzi J Bourhis E Deutsch, Nat Clin Pract Oncol 2007 4 591 602 10.1038/ncponc0934 17898809
-
(2007)
Nat Clin Pract Oncol
, vol.4
, pp. 591-602
-
-
Tao, Y.1
Pinzi, V.2
Bourhis, J.3
Deutsch, E.4
-
16
-
-
0033585421
-
Plasma levels of insulin-like growth factor-I and lung cancer risk: A case-control analysis
-
10.1093/jnci/91.2.151. 9923856
-
Plasma levels of insulin-like growth factor-I and lung cancer risk: a case-control analysis. H Yu MR Spitz J Mistry J Gu WK Hong X Wu, J Natl Cancer Inst 1999 91 151 156 10.1093/jnci/91.2.151 9923856
-
(1999)
J Natl Cancer Inst
, vol.91
, pp. 151-156
-
-
Yu, H.1
Spitz, M.R.2
Mistry, J.3
Gu, J.4
Hong, W.K.5
Wu, X.6
-
17
-
-
70449699792
-
Intracellular presence of insulin and its phosphorylated receptor in non-small cell lung cancer
-
10.1002/jcp.21916. 19688775
-
Intracellular presence of insulin and its phosphorylated receptor in non-small cell lung cancer. S Mattarocci C Abbruzzese AM Mileo P Visca B Antoniani G Alessandrini F Facciolo A Felsani RT Radulescu MG Paggi, J Cell Physiol 2009 221 766 770 10.1002/jcp.21916 19688775
-
(2009)
J Cell Physiol
, vol.221
, pp. 766-770
-
-
Mattarocci, S.1
Abbruzzese, C.2
Mileo, A.M.3
Visca, P.4
Antoniani, B.5
Alessandrini, G.6
Facciolo, F.7
Felsani, A.8
Radulescu, R.T.9
Paggi, M.G.10
-
18
-
-
38049110518
-
Silencing of the type 1 insulin-like growth factor receptor increases the sensitivity to apoptosis and inhibits invasion in human lung adenocarcinoma A549 cells
-
10.2478/s11658-007-0022-1. 17588222
-
Silencing of the type 1 insulin-like growth factor receptor increases the sensitivity to apoptosis and inhibits invasion in human lung adenocarcinoma A549 cells. Z Ma A Dong M Kong J Qian, Cell Mol Biol Lett 2007 12 556 572 10.2478/s11658-007-0022-1 17588222
-
(2007)
Cell Mol Biol Lett
, vol.12
, pp. 556-572
-
-
Ma, Z.1
Dong, A.2
Kong, M.3
Qian, J.4
-
19
-
-
58149229326
-
Klotho: A tumor suppressor and a modulator of the IGF-1 and FGF pathways in human breast cancer
-
10.1038/onc.2008.292. 18762812
-
Klotho: a tumor suppressor and a modulator of the IGF-1 and FGF pathways in human breast cancer. I Wolf S Levanon-Cohen S Bose H Ligumsky B Sredni H Kanety M Kuro-o B Karlan B Kaufman HP Koeffler T Rubinek, Oncogene 2008 27 7094 7105 10.1038/onc.2008.292 18762812
-
(2008)
Oncogene
, vol.27
, pp. 7094-7105
-
-
Wolf, I.1
Levanon-Cohen, S.2
Bose, S.3
Ligumsky, H.4
Sredni, B.5
Kanety, H.6
Kuro-O, M.7
Karlan, B.8
Kaufman, B.9
Koeffler, H.P.10
Rubinek, T.11
-
20
-
-
34247167175
-
Down-regulation of IGF-IR using small, interfering, hairpin RNA (siRNA) inhibits growth of human lung cancer cell line A549 in vitro and in nude mice
-
10.1016/j.cellbi.2006.11.017. 17196841
-
Down-regulation of IGF-IR using small, interfering, hairpin RNA (siRNA) inhibits growth of human lung cancer cell line A549 in vitro and in nude mice. AQ Dong MJ Kong ZY Ma JF Qian XH Xu, Cell Biol Int 2007 31 500 507 10.1016/j.cellbi.2006.11.017 17196841
-
(2007)
Cell Biol Int
, vol.31
, pp. 500-507
-
-
Dong, A.Q.1
Kong, M.J.2
Ma, Z.Y.3
Qian, J.F.4
Xu, X.H.5
-
21
-
-
33749342012
-
Klotho RNAi induces premature senescence of human cells via a p53/p21 dependent pathway
-
10.1016/j.febslet.2006.09.036. 17014852
-
Klotho RNAi induces premature senescence of human cells via a p53/p21 dependent pathway. RM de Oliveira, FEBS Lett 2006 580 5753 5758 10.1016/j.febslet.2006.09.036 17014852
-
(2006)
FEBS Lett
, vol.580
, pp. 5753-5758
-
-
De Oliveira, R.M.1
-
22
-
-
0037423695
-
Upregulation of cAMP is a new functional signal pathway of Klotho in endothelial cells
-
10.1016/S0006-291X(02)03056-5. 12565878
-
Upregulation of cAMP is a new functional signal pathway of Klotho in endothelial cells. J Yang N Matsukawa H Rakugi M Imai I Kida M Nagai J Ohta K Fukuo Y Nabeshima T Ogihara, Biochem Biophys Res Commun 2003 301 424 429 10.1016/S0006-291X(02)03056-5 12565878
-
(2003)
Biochem Biophys Res Commun
, vol.301
, pp. 424-429
-
-
Yang, J.1
Matsukawa, N.2
Rakugi, H.3
Imai, M.4
Kida, I.5
Nagai, M.6
Ohta, J.7
Fukuo, K.8
Nabeshima, Y.9
Ogihara, T.10
-
23
-
-
48549092932
-
Molecular profile of the BCL2 family of the apoptosis related genes in breast cancer cells after treatment with cytotoxic/cytostatic drugs
-
10.1080/03008200802147829. 18661356
-
Molecular profile of the BCL2 family of the apoptosis related genes in breast cancer cells after treatment with cytotoxic/cytostatic drugs. H Thomadaki A Scorilas, Connect Tissue Res 2008 49 261 264 10.1080/03008200802147829 18661356
-
(2008)
Connect Tissue Res
, vol.49
, pp. 261-264
-
-
Thomadaki, H.1
Scorilas, A.2
-
24
-
-
0034641918
-
The biochemistry of apoptosis
-
10.1038/35037710. 11048727
-
The biochemistry of apoptosis. MO Hengartner, Nature 2000 407 770 776 10.1038/35037710 11048727
-
(2000)
Nature
, vol.407
, pp. 770-776
-
-
Hengartner, M.O.1
-
25
-
-
0030584079
-
Apoptosis meets signal transduction: Elimination of a BAD influence
-
10.1016/S0092-8674(00)81377-X. 8929527
-
Apoptosis meets signal transduction: elimination of a BAD influence. TF Gajewski CB Thompson, Cell 1996 87 589 592 10.1016/S0092-8674(00)81377-X 8929527
-
(1996)
Cell
, vol.87
, pp. 589-592
-
-
Gajewski, T.F.1
Thompson, C.B.2
-
26
-
-
47949099916
-
From endoplasmic-reticulum stress to the inflammatory response
-
10.1038/nature07203. 18650916
-
From endoplasmic-reticulum stress to the inflammatory response. K Zhang RJ Kaufman, Nature 2008 454 455 462 10.1038/nature07203 18650916
-
(2008)
Nature
, vol.454
, pp. 455-462
-
-
Zhang, K.1
Kaufman, R.J.2
|