Fatting the brain: A brief of recent research

Frontiers in Cellular Neuroscience

Volumn , Issue SEP, 2013, Pages

  Hussain, Ghulam ^a   Schmitt, Florent ^a   Loeffler, Jean Philippe ^a   de Aguilar, Jose Luis Gonzalez ^a  

^a UNIVERSITÉ DE STRASBOURG   (France)

Author keywords

Monounsaturated fatty acid; Neurodegenerative disease; Neurological disease; Peripheral nerve; Polyunsaturated fatty acid; Saturated fatty acid

Indexed keywords

AMYLOID BETA PROTEIN; ARACHIDONIC ACID; BRAIN DERIVED NEUROTROPHIC FACTOR; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; CASPASE 3; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; DOCOSAHEXAENOIC ACID; FATTY ACID; ICOSAPENTAENOIC ACID; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; LAURIC ACID; LINOLENIC ACID; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MONOUNSATURATED FATTY ACID; OLEIC ACID; OMEGA 3 FATTY ACID; OMEGA 6 FATTY ACID; PALMITIC ACID; POLYUNSATURATED FATTY ACID; PROTEIN BAX; PROTEIN BCL 2; PROTEIN C FOS; SATURATED FATTY ACID; STEARIC ACID; SYNAPSIN I; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA; UNINDEXED DRUG;

ALZHEIMER DISEASE; AMYLOID PLAQUE; APOPTOSIS; BRAIN HEMORRHAGE; BRAIN HYPOXIA; BRAIN ISCHEMIA; BRAIN LEVEL; CINGULATE GYRUS; COGNITION; CYTOKINE RELEASE; DEMYELINATION; DEPRESSION; DISEASE ASSOCIATION; DISEASE MODEL; FAT INTAKE; FATTY ACID METABOLISM; FATTY ACID SYNTHESIS; GENE EXPRESSION; HIPPOCAMPUS; HYPOTHALAMUS; LIPID COMPOSITION; LIPID RAFT; LONG TERM POTENTIATION; MICROGLIA; MULTIPLE SCLEROSIS; NERVE CELL STIMULATION; NERVE DEGENERATION; NERVOUS SYSTEM DEVELOPMENT; NERVOUS SYSTEM FUNCTION; NERVOUS SYSTEM INFLAMMATION; NEUROLOGIC DISEASE; NEURONAL CEROID LIPOFUSCINOSIS; NEUROPROTECTION; NEUROTRANSMISSION; NIGRONEOSTRIATAL SYSTEM; NONHUMAN; ORBITAL CORTEX; PARKINSON DISEASE; PERIPHERAL NERVE; PROTEIN AGGREGATION; PROTEIN EXPRESSION; REVIEW; SCHIZOPHRENIA; SPINAL CORD INJURY; SYNAPTOGENESIS; TRAUMATIC BRAIN INJURY;

EID: 84885169093     PISSN: 16625102     EISSN: None     Source Type: Journal    
DOI: 10.3389/fncel.2013.00144     Document Type: Review

References (124)

1. Amtul, Z., Uhrig, M., Rozmahel, R. F., and Beyreuther, K. (2011a). Structural insight into the differential effects of omega-3 and omega-6 fatty acids on the production of Abeta peptides and amyloid plaques. J. Biol. Chem. 286, 6100-6107. doi: 10.1074/jbc.M110.183608
2. Amtul, Z., Westaway, D., Cechetto, D. F., and Rozmahel, R. F. (2011b). Oleic acid ameliorates amyloidosis in cellular and mouse models of Alzheimer's disease. Brain Pathol. 21, 321-329. doi: 10.1111/j.1750-3639.2010.00449.x
3. Amtul, Z., Uhrig, M., Wang, L., Rozmahel, R. F., and Beyreuther, K. (2012). Detrimental effects of arachidonic acid and its metabolites in cellular and mouse models of Alzheimer's disease: structural insight. Neurobiol. Aging 33, 831. e21-31. doi: 10.1016/j.neurobiolaging.2011.07.014
4. Astarita, G., Jung, K.-M., Vasilevko, V., Dipatrizio, N. V., Martin, S. K., Cribbs, D. H., et al. (2011). Elevated stearoyl-CoA desaturase in brains of patients with Alzheimer's disease. PLoS ONE 6:e24777. doi: 10.1371/journal.pone.0024777
5. Avraham, Y., Saidian, M., Burston, J. J., Mevorach, R., Vorobiev, L., Magen, I., et al. (2011). Fish oil promotes survival and protects against cognitive decline in severely undernourished mice by normalizing satiety signals. J. Nutr. Biochem. 22, 766-776. doi: 10.1016/j.jnutbio.2010.07.001
6. Balanzá-Martïnez, V., Fries, G. R., Colpo, G. D., Silveira, P. P., Portella, A. K., Tabarés-Seisdedos, R., et al. (2011). Therapeutic use of omega-3 fatty acids in bipolar disorder. Expert Rev. Neurother. 11, 1029-1047. doi: 10.1586/ern.11.42
7. Bate, C., Tayebi, M., Salmona, M., Diomede, L., and Williams, A. (2010). Polyunsaturated fatty acids protect against prion-mediated synapse damage in vitro. Neurotox. Res. 17, 203-214. doi: 10.1007/s12640-009-9093-2
8. Bazan, N. G. (2009). Cellular and molecular events mediated by docosahexaenoic acid-derived neuroprotectin D1 signaling in photoreceptor cell survival and brain protection. Prostaglandins Leukot. Essent. Fatty Acids 81, 205-211. doi: 10.1016/j.plefa.2009.05.024
9. Blondeau, N., Nguemeni, C., Debruyne, D. N., Piens, M., Wu, X., Pan, H., et al. (2009). Subchronic alpha-linolenic acid treatment enhances brain plasticity and exerts an antidepressant effect: a versatile potential therapy for stroke. Neuropsychopharmacology34, 2548-2559. doi: 10.1038/npp.2009.84
10. Boneva, N. B., Kaplamadzhiev, D. B., Sahara, S., Kikuchi, H., Pyko, I. V, Kikuchi, M., et al. (2011a). Expression of fatty acid-binding proteins in adult hippocampal neurogenic niche of postischemic monkeys. Hippocampus 21, 162-171. doi: 10.1002/hipo.20732
11. Boneva, N. B., Kikuchi, M., Minabe, Y., and Yamashima, T. (2011b). Neuroprotective and ameliorative actions of polyunsaturated fatty acids against neuronal diseases: implication of fatty acid-binding proteins (FABP) and G protein-coupled receptor 40 (GPR40) in adult neurogenesis. J. Pharmacol. Sci. 116, 163-172. doi: 10.1254/jphs.10R34FM
12. Boudrault, C., Bazinet, R. P., and Ma, D. W. L. (2009). Experimental models and mechanisms underlying the protective effects of n-3 polyunsaturated fatty acids in Alzheimer's disease. J. Nutr. Biochem. 20, 1-10. doi: 10.1016/j.jnutbio.2008.05.016
13. Bousquet, M., Calon, F., and Cicchetti, F. (2011). Impact of ω-3 fatty acids in Parkinson's disease. Ageing Res. Rev. 10, 453-463. doi: 10.1016/j.arr.2011.03.001
14. Bousquet, M., Gibrat, C., Saint-Pierre, M., Julien, C., Calon, F., and Cicchetti, F. (2009). Modulation of brain-derived neurotrophic factor as a potential neuroprotective mechanism of action of omega-3 fatty acids in a parkinsonian animal model. Prog. Neuropsychopharmacol. Biol. Psychiatry 33, 1401-1408. doi: 10.1016/j.pnpbp.2009.07.018
15. Bousquet, M., Saint-Pierre, M., Julien, C., Salem, N., Cicchetti, F., and Calon, F. (2008). Beneficial effects of dietary omega-3 polyunsaturated fatty acid on toxin-induced neuronal degeneration in an animal model of Parkinson's disease. FASEB J. 22, 1213-1225. doi: 10.1096/fj.07-9677com
16. Bradbury, J. (2011). Docosahexaenoic acid (DHA): an ancient nutrient for the modern human brain. Nutrients 3, 529-554. doi: 10.3390/nu3050529
17. Brenna, J. T., Salem, N., Sinclair, A. J., and Cunnane, S. C. (2009). alpha-Linolenic acid supplementation and conversion to n-3 long-chain polyunsaturated fatty acids in humans. Prostaglandins Leukot. Essent. Fatty Acids 80, 85-91. doi: 10.1016/j.plefa.2009.01.004
18. Chen, H.-F., and Su, H.-M. (2012). Fish oil supplementation of maternal rats on an n-3 fatty acid-deficient diet prevents depletion of maternal brain regional docosahexaenoic acid levels and has a postpartum anxiolytic effect. J. Nutr. Biochem. 23, 299-305. doi: 10.1016/j.jnutbio.2010.12.010
19. Choi, S. J., Kim, F., Schwartz, M. W., and Wisse, B. E. (2010). Cultured hypothalamic neurons are resistant to inflammation and insulin resistance induced by saturated fatty acids. Am. J. Physiol. Endocrinol. Metab. 298, E1122-E1130. doi: 10.1152/ajpendo.00006.2010
20. Chung, W.-L., Chen, J.-J., and Su, H.-M. (2008). Fish oil supplementation of control and (n-3) fatty acid-deficient male rats enhances reference and working memory performance and increases brain regional docosahexaenoic acid levels. J. Nutr. 138, 1165-1171.
21. Coluccia, A., Borracci, P., Renna, G., Giustino, A., Latronico, T., Riccio, P., et al. (2009). Developmental omega-3 supplementation improves motor skills in juvenile-adult rats. Int. J. Dev. Neurosci. 27, 599-605. doi: 10.1016/j.ijdevneu.2009.05.011
22. Conklin, S. M., Runyan, C. A., Leonard, S., Reddy, R. D., Muldoon, M. F., and Yao, J. K. (2010). Age-related changes of n-3 and n-6 polyunsaturated fatty acids in the anterior cingulate cortex of individuals with major depressive disorder. Prostaglandins Leukot. Essent. Fatty Acids 82, 111-119. doi: 10.1016/j.plefa.2009.12.002
23. Connor, S., Tenorio, G., Clandinin, M. T., and Sauvé, Y. (2012). DHA supplementation enhances high-frequency, stimulation-induced synaptic transmission in mouse hippocampus. Appl. Physiol. Nutr. Metab. 37, 880-887. doi: 10.1139/h2012-062
24. Cortina, M. S., He, J., Li, N., Bazan, N. G., and Bazan, H. E. P. (2010). Neuroprotectin D1 synthesis and corneal nerve regeneration after experimental surgery and treatment with PEDF plus DHA. Invest. Ophthalmol. Vis. Sci. 51, 804-810. doi: 10.1167/iovs.09-3641
25. Cortina, M. S., He, J., Li, N., Bazan, N. G., and Bazan, H. E. P. (2012). Recovery of corneal sensitivity, calcitonin gene-related peptide-positive nerves, and increased wound healing induced by pigment epithelial-derived factor plus docosahexaenoic acid after experimental surgery. Arch. Ophthalmol. 130, 76-83. doi: 10.1001/archophthalmol.2011.287
26. Crupi, R., Cambiaghi, M., Deckelbaum, R., Hansen, I., Mindes, J., Spina, E., et al. (2012). n-3 fatty acids prevent impairment of neurogenesis and synaptic plasticity in B-cell activating factor (BAFF) transgenic mice. Prev. Med. 54(Suppl.), S103-S108. doi: 10.1016/j.ypmed.2011.12.019
27. De Franceschi, G., Frare, E., Bubacco, L., Mammi, S., Fontana, A., and De Laureto, P. P. (2009). Molecular insights into the interaction between alpha-synuclein and docosahexaenoic acid. J. Mol. Biol. 394, 94-107. doi: 10.1016/j.jmb.2009.09.008
28. De Franceschi, G., Frare, E., Pivato, M., Relini, A., Penco, A., Greggio, E., et al. (2011). Structural and morphological characterization of aggregated species of α-synuclein induced by docosahexaenoic acid. J. Biol. Chem. 286, 22262-22274. doi: 10.1074/jbc.M110.202937
29. Delattre, A. M., Kiss, A., Szawka, R. E., Anselmo-Franci, J. A., Bagatini, P. B., Xavier, L. L., et al. (2010). Evaluation of chronic omega-3 fatty acids supplementation on behavioral and neurochemical alterations in 6-hydroxydopamine-lesion model of Parkinson's disease. Neurosci. Res. 66, 256-264. doi: 10.1016/j.neures.2009.11.006
30. Dyall, S. C., Michael, G. J., and Michael-Titus, A. T. (2010). Omega-3 fatty acids reverse age-related decreases in nuclear receptors and increase neurogenesis in old rats. J. Neurosci. Res.88, 2091-2102. doi: 10.1002/jnr.22390
31. Enoch, H. G., Catala, A., and Strittmatter, P. (1976). Mechanism of rat liver microsomal stearyl-CoA desaturase. Studies of the substrate specificity, enzyme-substrate interactions, and the function of lipid. J. Biol. Chem. 251, 5095-5103.
32. Etschmaier, K., Becker, T., Eichmann, T. O., Schweinzer, C., Scholler, M., Tam-Amersdorfer, C., et al. (2011). Adipose triglyceride lipase affects triacylglycerol metabolism at brain barriers. J. Neurochem. 119, 1016-1028. doi: 10.1111/j.1471-4159.2011.07498.x
33. Fabelo, N., Martïn, V., Santpere, G., Marïn, R., Torrent, L., Ferrer, I., et al. (2011). Severe alterations in lipid composition of frontal cortex lipid rafts from Parkinson's disease and incidental Parkinson's disease. Mol. Med. 17, 1107-1118. doi: 10.2119/molmed.2011.00119
34. Fick, L. J., Fick, G. H., and Belsham, D. D. (2011). Palmitate alters the rhythmic expression of molecular clock genes and orexigenic neuropeptide Y mRNA levels within immortalized, hypothalamic neurons. Biochem. Biophys. Res. Commun. 413, 414-419. doi: 10.1016/j.bbrc.2011.08.103
35. Figueroa, J. D., Cordero, K., Baldeosingh, K., Torrado, A. I., Walker, R. L., Miranda, J. D., et al. (2012). Docosahexaenoic acid pretreatment confers protection and functional improvements after acute spinal cord injury in adult rats. J. Neurotrauma 29, 551-566. doi: 10.1089/neu.2011.2141
36. Fraser, T., Tayler, H., and Love, S. (2010). Fatty acid composition of frontal, temporal and parietal neocortex in the normal human brain and in Alzheimer's disease. Neurochem. Res.35, 503-513. doi: 10.1007/s11064-009-0087-5
37. Georgiadi, A., and Kersten, S. (2012). Mechanisms of gene regulation by fatty acids. Adv. Nutr. 3, 127-134. doi: 10.3945/an.111.001602
38. Gladman, S. J., Huang, W., Lim, S.-N., Dyall, S. C., Boddy, S., Kang, J. X., et al. (2012). Improved outcome after peripheral nerve injury in mice with increased levels of endogenous ω-3 polyunsaturated fatty acids. J. Neurosci. 32, 563-571. doi: 10.1523/JNEUROSCI.3371-11.2012
39. Gupta, S., Knight, A. G., Gupta, S., Keller, J. N., and Bruce-Keller, A. J. (2012). Saturated long-chain fatty acids activate inflammatory signaling in astrocytes. J. Neurochem. 120, 1060-1071.
40. Hamazaki, K., Choi, K. H., and Kim, H.-Y. (2010). Phospholipid profile in the postmortem hippocampus of patients with schizophrenia and bipolar disorder: no changes in docosahexaenoic acid species. J. Psychiatr. Res. 44, 688-693. doi: 10.1016/j.jpsychires.2009.11.017
41. Hamazaki, K., Hamazaki, T., and Inadera, H. (2012). Fatty acid composition in the postmortem amygdala of patients with schizophrenia, bipolar disorder, and major depressive disorder. J. Psychiatr. Res. 46, 1024-1028. doi: 10.1016/j.jpsychires.2012.04.012
42. Harbeby, E., Jouin, M., Alessandri, J.-M., Lallemand, M.-S., Linard, A., Lavialle, M., et al. (2012). n-3 PUFA status affects expression of genes involved in neuroenergetics differently in the fronto-parietal cortex compared to the CA1 area of the hippocampus: effect of rest and neuronal activation in the rat. Prostaglandins Leukot. Essent. Fatty Acids 86, 211-220. doi: 10.1016/j.plefa.2012.04.008
43. Hirakawa, A., Shimizu, K., Fukumitsu, H., Soumiya, H., Iinuma, M., and Furukawa, S. (2010). 2-Decenoic acid ethyl ester, a derivative of unsaturated medium-chain fatty acids, facilitates functional recovery of locomotor activity after spinal cord injury. Neuroscience 171, 1377-1385. doi: 10.1016/j.neuroscience.2010.10.004
44. Hunt, W. T., Kamboj, A., Anderson, H. D., and Anderson, C. M. (2010). Protection of cortical neurons from excitotoxicity by conjugated linoleic acid. J. Neurochem. 115, 123-130. doi: 10.1111/j.1471-4159.2010.06908.x
45. Hussain, G., Schmitt, F., Henriques, A., Lequeu, T., Rene, F., Bindler, F., et al. (2013). Systemic down-regulation of delta-9 desaturase promotes muscle oxidative metabolism and accelerates muscle function recovery following nerve injury. PLoS ONE 8:e64525. doi: 10.1371/journal.pone.0064525
46. Inceoglu, B., Wagner, K. M., Yang, J., Bettaieb, A., Schebb, N. H., Hwang, S. H., et al. (2012). Acute augmentation of epoxygenated fatty acid levels rapidly reduces pain-related behavior in a rat model of type I diabetes. Proc. Natl. Acad. Sci. U.S.A. 109, 11390-11395. doi: 10.1073/pnas.1208708109
47. IUPAC. (1997). Compendium of Chemical Terminology, 2nd Edn (the "Gold Book"). Compiled by A. D. McNaught and A. Wilkinson. Oxford: Blackwell Scientific Publications.
48. Ji, A., Diao, H., Wang, X., Yang, R., Zhang, J., Luo, W., et al. (2012). N-3 Polyunsaturated fatty acids inhibit lipopolysaccharide-induced microglial activation and dopaminergic injury in rats. Neurotoxicology 33, 780-788. doi: 10.1016/j.neuro.2012.02.018
49. Katakura, M., Hashimoto, M., Okui, T., Shahdat, H. M., Matsuzaki, K., and Shido, O. (2013). Omega-3 polyunsaturated fatty acids enhance neuronal differentiation in cultured rat neural stem cells. Stem Cells Int. 2013, 490476. doi: 10.1155/2013/490476
50. Kawashima, A., Harada, T., Kami, H., Yano, T., Imada, K., and Mizuguchi, K. (2010). Effects of eicosapentaenoic acid on synaptic plasticity, fatty acid profile and phosphoinositide 3-kinase signaling in rat hippocampus and differentiated PC12 cells. J. Nutr. Biochem. 21, 268-277. doi: 10.1016/j.jnutbio.2008.12.015
51. Kelly, L., Grehan, B., Chiesa, A. D., O'Mara, S. M., Downer, E., Sahyoun, G., et al. (2011). The polyunsaturated fatty acids, EPA and DPA exert a protective effect in the hippocampus of the aged rat. Neurobiol. Aging 32, 2318. e1-15. doi: 10.1016/j.neurobiolaging.2010.04.001
52. Kenchegowda, S., He, J., and Bazan, H. E. P. (2013). Involvement of pigment epithelium-derived factor, docosahexaenoic acid and neuroprotectin D1 in corneal inflammation and nerve integrity after refractive surgery. Prostaglandins Leukot. Essent. Fatty Acids 88, 27-31. doi: 10.1016/j.plefa.2012.03.010
53. Kim, S.-J., Zhang, Z., Saha, A., Sarkar, C., Zhao, Z., Xu, Y., et al. (2010). Omega-3 and omega-6 fatty acids suppress ER-and oxidative stress in cultured neurons and neuronal progenitor cells from mice lacking PPT1. Neurosci. Lett. 479, 292-296. doi: 10.1016/j.neulet.2010.05.083
54. Labrousse, V. F., Nadjar, A., Joffre, C., Costes, L., Aubert, A., Grégoire, S., et al. (2012). Short-term long chain omega3 diet protects from neuroinflammatory processes and memory impairment in aged mice. PLoS ONE 7:e36861. doi: 10.1371/journal.pone.0036861
55. Lafourcade, M., Larrieu, T., Mato, S., Duffaud, A., Sepers, M., Matias, I., et al. (2011). Nutritional omega-3 deficiency abolishes endocannabinoid-mediated neuronal functions. Nat. Neurosci. 14, 345-350. doi: 10.1038/nn.2736
56. Lands, B. (2012). Consequences of essential fatty acids. Nutrients 4, 1338-1357. doi: 10.3390/nu4091338
57. Lebbadi, M., Julien, C., Phivilay, A., Tremblay, C., Emond, V., Kang, J. X., et al. (2011). Endogenous conversion of omega-6 into omega-3 fatty acids improves neuropathology in an animal model of Alzheimer's disease. J. Alzheimers Dis. 27, 853-869. doi: 10.3233/JAD-2011-111010
58. Lee, J. C.-M., Simonyi, A., Sun, A. Y., and Sun, G. Y. (2011). Phospholipases A2 and neural membrane dynamics: implications for Alzheimer's disease. J. Neurochem. 116, 813-819. doi: 10.1111/j.1471-4159.2010.07033.x
59. Li, F., Marchette, L. D., Brush, R. S., Elliott, M. H., Davis, K. R., Anderson, A. G., et al. (2010). High levels of retinal docosahexaenoic acid do not protect photoreceptor degeneration in VPP transgenic mice. Mol. Vis. 16, 1669-1679.
60. Li, F., Marchette, L. D., Brush, R. S., Elliott, M. H., Le, Y.-Z., Henry, K. A., et al. (2009). DHA does not protect ELOVL4 transgenic mice from retinal degeneration. Mol. Vis. 15, 1185-1193.
61. Lim, S.-N., Gladman, S. J., Dyall, S. C., Patel, U., Virani, N., Kang, J. X., et al. (2013a). Transgenic mice with high endogenous omega-3 fatty acids are protected from spinal cord injury. Neurobiol. Dis. 51, 104-112. doi: 10.1016/j.nbd.2012.10.021
62. Lim, S.-N., Huang, W., Hall, J. C. E., Michael-Titus, A. T., and Priestley, J. V. (2013b). Improved outcome after spinal cord compression injury in mice treated with docosahexaenoic acid. Exp. Neurol. 239, 13-27. doi: 10.1016/j.expneurol.2012.09.015
63. Lin, P.-Y., Huang, S.-Y., and Su, K.-P. (2010). A meta-analytic review of polyunsaturated fatty acid compositions in patients with depression. Biol. Psychiatry 68, 140-147. doi: 10.1016/j.biopsych.2010.03.018
64. Liu, R.-Z., Mita, R., Beaulieu, M., Gao, Z., and Godbout, R. (2010). Fatty acid binding proteins in brain development and disease. Int. J. Dev. Biol. 54, 1229-1239. doi: 10.1387/ijdb.092976rl
65. Luchtman, D. W., Meng, Q., and Song, C. (2012). Ethyl-eicosapentaenoate (E-EPA) attenuates motor impairments and inflammation in the MPTP-probenecid mouse model of Parkinson's disease. Behav. Brain Res. 226, 386-396. doi: 10.1016/j.bbr.2011.09.033
66. Luchtman, D. W., and Song, C. (2013). Cognitive enhancement by omega-3 fatty acids from childhood to old age: findings from animal and clinical studies. Neuropharmacology 64, 550-565. doi: 10.1016/j.neuropharm.2012.07.019
67. Ma, D., Zhang, M., Mori, Y., Yao, C., Larsen, C. P., Yamashima, T., et al. (2010). Cellular localization of epidermal-type and brain-type fatty acid-binding proteins in adult hippocampus and their response to cerebral ischemia. Hippocampus 20, 811-819. doi: 10.1002/hipo.20682
68. Ma, Q.-L., Yang, F., Rosario, E. R., Ubeda, O. J., Beech, W., Gant, D. J., et al. (2009). Beta-amyloid oligomers induce phosphorylation of tau and inactivation of insulin receptor substrate via c-Jun N-terminal kinase signaling: suppression by omega-3 fatty acids and curcumin. J. Neurosci. 29, 9078-9089. doi: 10.1523/JNEUROSCI.1071-09.2009
69. Maekawa, M., Takashima, N., Matsumata, M., Ikegami, S., Kontani, M., Hara, Y., et al. (2009). Arachidonic acid drives postnatal neurogenesis and elicits a beneficial effect on prepulse inhibition, a biological trait of psychiatric illnesses. PLoS ONE 4:e5085. doi: 10.1371/journal.pone.0005085
70. Martïn, V., Fabelo, N., Santpere, G., Puig, B., Marïn, R., Ferrer, I., et al. (2010). Lipid alterations in lipid rafts from Alzheimer's disease human brain cortex. J. Alzheimers Dis. 19, 489-502. doi: 10.3233/JAD-2010-1242
71. Mathieu, G., Géraldine, M., Denis, S., Stéphanie, D., Langelier, B., Bénédicte, L., et al. (2010). DHA enhances the noradrenaline release by SH-SY5Y cells. Neurochem. Int. 56, 94-100. doi: 10.1016/j.neuint.2009.09.006
72. Mayer, C. M., and Belsham, D. D. (2010). Palmitate attenuates insulin signaling and induces endoplasmic reticulum stress and apoptosis in hypothalamic neurons: rescue of resistance and apoptosis through adenosine 5′ monophosphate-activated protein kinase activation. Endocrinology 151, 576-585. doi: 10.1210/en.2009-1122
73. McNamara, R. K., and Liu, Y. (2011). Reduced expression of fatty acid biosynthesis genes in the prefrontal cortex of patients with major depressive disorder. J. Affect. Disord. 129, 359-363. doi: 10.1016/j.jad.2010.08.021
74. Ménard, C., Patenaude, C., Gagné, A.-M., and Massicotte, G. (2009). AMPA receptor-mediated cell death is reduced by docosahexaenoic acid but not by eicosapentaenoic acid in area CA1 of hippocampal slice cultures. J. Neurosci. Res. 87, 876-886. doi: 10.1002/jnr.21916
75. Meng, Q., Luchtman, D. W., El Bahh, B., Zidichouski, J. A., Yang, J., and Song, C. (2010). Ethyl-eicosapentaenoate modulates changes in neurochemistry and brain lipids induced by parkinsonian neurotoxin 1-methyl-4-phenylpyridinium in mouse brain slices. Eur. J. Pharmacol. 649, 127-134. doi: 10.1016/j.ejphar.2010.09.046
76. Milanski, M., Degasperi, G., Coope, A., Morari, J., Denis, R., Cintra, D. E., et al. (2009). Saturated fatty acids produce an inflammatory response predominantly through the activation of TLR4 signaling in hypothalamus: implications for the pathogenesis of obesity. J. Neurosci. 29, 359-370. doi: 10.1523/JNEUROSCI.2760-08.2009
77. Moreira, J. D., Knorr, L., Ganzella, M., Thomazi, A. P., De Souza, C. G., De Souza, D. G., et al. (2010a). Omega-3 fatty acids deprivation affects ontogeny of glutamatergic synapses in rats: relevance for behavior alterations. Neurochem. Int. 56, 753-759. doi: 10.1016/j.neuint.2010.02.010
78. Moreira, J. D., Knorr, L., Thomazi, A. P., Simúo, F., Battú, C., Oses, J. P., et al. (2010b). Dietary omega-3 fatty acids attenuate cellular damage after a hippocampal ischemic insult in adult rats. J. Nutr. Biochem. 21, 351-356. doi: 10.1016/j.jnutbio.2009.01.013
79. Motter, A. L., and Ahern, G. P. (2012). TRPA1 is a polyunsaturated fatty acid sensor in mammals. PLoS ONE 7:e38439. doi: 10.1371/journal.pone.0038439
80. Muntané, G., Janué, A., Fernandez, N., Odena, M. A., Oliveira, E., Boluda, S., et al. (2010). Modification of brain lipids but not phenotype in alpha-synucleinopathy transgenic mice by long-term dietary n-3 fatty acids. Neurochem. Int. 56, 318-328. doi: 10.1016/j.neuint.2009.10.015
81. Musto, A. E., Gjorstrup, P., and Bazan, N. G. (2011). The omega-3 fatty acid-derived neuroprotectin D1 limits hippocampal hyperexcitability and seizure susceptibility in kindling epileptogenesis. Epilepsia 52, 1601-1608. doi: 10.1111/j.1528-1167.2011.03081.x
82. Nakamura, M. T., and Nara, T. Y. (2004). Structure, function, and dietary regulation of delta6, delta5, and delta9 desaturases. Annu. Rev. Nutr. 24, 345-376. doi: 10.1146/annurev.nutr.24.121803.063211
83. Niculescu, M. D., Lupu, D. S., and Craciunescu, C. N. (2011). Maternal α-linolenic acid availability during gestation and lactation alters the postnatal hippocampal development in the mouse offspring. Int. J. Dev. Neurosci. 29, 795-802. doi: 10.1016/j.ijdevneu.2011.09.006
84. Ochoa, J. J., Pamplona, R., Ramirez-Tortosa, M. C., Granados-Principal, S., Perez-Lopez, P., Naudï, A., et al. (2011). Age-related changes in brain mitochondrial DNA deletion and oxidative stress are differentially modulated by dietary fat type and coenzyme Q1. Free Radic. Biol. Med. 50, 1053-1064. doi: 10.1016/j.freeradbiomed.2011.02.004
85. Palacios-Pelaez, R., Lukiw, W. J., and Bazan, N. G. (2010). Omega-3 essential fatty acids modulate initiation and progression of neurodegenerative disease. Mol. Neurobiol. 41, 367-374. doi: 10.1007/s12035-010-8139-z
86. Pan, J.-P., Zhang, H.-Q., Wei-Wang, Guo, Y.-F., Na-Xiao, Cao, X.-H., et al. (2011). Some subtypes of endocannabinoid/endovanilloid receptors mediate docosahexaenoic acid-induced enhanced spatial memory in rats. Brain Res. 1412, 18-27. doi: 10.1016/j.brainres.2011.07.015
87. Park, C.-K., Lü, N., Xu, Z.-Z., Liu, T., Serhan, C. N., and Ji, R.-R. (2011). Resolving TRPV1-and TNF-α-mediated spinal cord synaptic plasticity and inflammatory pain with neuroprotectin D1. J. Neurosci. 31, 15072-15085. doi: 10.1523/JNEUROSCI.2443-11.2011
88. Park, Y., Moon, H.-J., and Kim, S.-H. (2012). N-3 polyunsaturated fatty acid consumption produces neurobiological effects associated with prevention of depression in rats after the forced swimming test. J. Nutr. Biochem. 23, 924-928. doi: 10.1016/j.jnutbio.2011.04.018
89. Park, Y., Nam, S., Yi, H.-J., Hong, H.-J., and Lee, M. (2009). Dietary n-3 polyunsaturated fatty acids increase oxidative stress in rats with intracerebral hemorrhagic stroke. Nutr. Res.29, 812-818. doi: 10.1016/j.nutres.2009.10.019
90. Peters, B. D., Duran, M., Vlieger, E. J., Majoie, C. B., Den Heeten, G. J., Linszen, D. H., et al. (2009). Polyunsaturated fatty acids and brain white matter anisotropy in recent-onset schizophrenia: a preliminary study. Prostaglandins Leukot. Essent. Fatty Acids 81, 61-63. doi: 10.1016/j.plefa.2009.04.007
91. Porta, N., Bourgois, B., Galabert, C., Lecointe, C., Cappy, P., Bordet, R., et al. (2009). Anticonvulsant effects of linolenic acid are unrelated to brain phospholipid cell membrane compositions. Epilepsia 50, 65-71. doi: 10.1111/j.1528-1167.2008.01723.x
92. Prior, P. L., and Galduróz, J. C. (2012). (N-3) Fatty acids: molecular role and clinical uses in psychiatric disorders. Adv. Nutr. 3, 257-265. doi: 10.3945/an.111.001693
93. Rashid, M. A., Katakura, M., Kharebava, G., Kevala, K., and Kim, H. Y. (2013). N-Docosahexaenoylethanolamine is a potent neurogenic factor for neural stem cell differentiation. J. Neurochem. 125, 869-884. doi: 10.1111/jnc.12255
94. Robson, L. G., Dyall, S., Sidloff, D., and Michael-Titus, A. T. (2010). Omega-3 polyunsaturated fatty acids increase the neurite outgrowth of rat sensory neurones throughout development and in aged animals. Neurobiol. Aging 31, 678-687. doi: 10.1016/j.neurobiolaging.2008.05.027
95. Rombaldi Bernardi, J., De Souza Escobar, R., Ferreira, C. F., and Pelufo Silveira, P. (2012). Fetal and neonatal levels of omega-3: effects on neurodevelopment, nutrition, and growth. Sci. World J. 2012, 202473. doi: 10.1100/2012/202473
96. Ruzickova, J., Rossmeisl, M., Prazak, T., Flachs, P., Sponarova, J., Veck, M., et al. (2004). Omega-3 PUFA of marine origin limit diet-induced obesity in mice by reducing cellularity of adipose tissue. Lipids 39, 1177-1185. doi: 10.1007/s11745-004-1345-9
97. Sartorius, T., Ketterer, C., Kullmann, S., Balzer, M., Rotermund, C., Binder, S., et al. (2012). Monounsaturated fatty acids prevent the aversive effects of obesity on locomotion, brain activity, and sleep behavior. Diabetes 61, 1669-1679. doi: 10.2337/db11-1521
98. Schaeffer, E. L., Skaf, H. D., Novaes Bde, A., Da Silva, E. R., Martins, B. A., Joaquim, H. D., et al. (2011). Inhibition of phospholipase A2 in rat brain modifies different membrane fluidity parameters in opposite ways. Prog. Neuropsychopharmacol. Biol. Psychiatry 35, 1612-1617. doi: 10.1016/j.pnpbp.2011.05.001
99. Schleicher, M., Weikel, K., Garber, C., and Taylor, A. (2013). Diminishing risk for age-related macular degeneration with nutrition: a current view. Nutrients 5, 2405-2456. doi: 10.3390/nu5072405
100. Shchepinov, M. S., Chou, V. P., Pollock, E., Langston, J. W., Cantor, C. R., Molinari, R. J., et al. (2011). Isotopic reinforcement of essential polyunsaturated fatty acids diminishes nigrostriatal degeneration in a mouse model of Parkinson's disease. Toxicol. Lett. 207, 97-103. doi: 10.1016/j.toxlet.2011.07.020
101. Sidhu, V. K., Huang, B. X., and Kim, H. Y. (2011). Effects of docosahexaenoic acid on mouse brain synaptic plasma membrane proteome analyzed by mass spectrometry and (16)O/(18)O labeling. J. Proteome Res. 10, 5472-5480. doi: 10.1021/pr2007285
102. Simopoulos, A. P. (2011). Evolutionary aspects of diet: the omega-6/omega-3 ratio and the brain. Mol. Neurobiol. 44, 203-215. doi: 10.1007/s12035-010-8162-0
103. Taha, A. Y., Filo, E., Ma, D. W. L., and McIntyre Burnham, W. (2009). Dose-dependent anticonvulsant effects of linoleic and alpha-linolenic polyunsaturated fatty acids on pentylenetetrazol induced seizures in rats. Epilepsia 50, 72-82. doi: 10.1111/j.1528-1167.2008.01731.x
104. Tanito, M., Brush, R. S., Elliott, M. H., Wicker, L. D., Henry, K. R., and Anderson, R. E. (2009). High levels of retinal membrane docosahexaenoic acid increase susceptibility to stress-induced degeneration. J. Lipid Res. 50, 807-819. doi: 10.1194/jlr.M800170-JLR200
105. Tian, C., Fan, C., Liu, X., Xu, F., and Qi, K. (2011). Brain histological changes in young mice submitted to diets with different ratios of n-6/n-3 polyunsaturated fatty acids during maternal pregnancy and lactation. Clin. Nutr. 30, 659-667. doi: 10.1016/j.clnu.2011.03.002
106. Torkildsen, Ø., Brunborg, L. A., Milde, A. M., Mørk, S. J., Myhr, K.-M. (2009). A salmon based diet protects mice from behavioural changes in the cuprizone model for demyelination. Clin. Nutr. 28, 83-87. doi: 10.1016/j.clnu.2008.10.015
107. Uauy, R., and Dangour, A. D. (2006). Nutrition in brain development and aging: role of essential fatty acids. Nutr. Rev. 64, S24-S33. doi: 10.1301/nr.2006.may.S24-S33
108. Venna, V. R., Deplanque, D., Allet, C., Belarbi, K., Hamdane, M., and Bordet, R. (2009). PUFA induce antidepressant-like effects in parallel to structural and molecular changes in the hippocampus. Psychoneuroendocrinology 34, 199-211. doi: 10.1016/j.psyneuen.2008.08.025
109. Vines, A., Delattre, A. M., Lima, M. M. S., Rodrigues, L. S., Suchecki, D., Machado, R. B., et al. (2012). The role of 5-HT1 A receptors in fish oil-mediated increased BDNF expression in the rat hippocampus and cortex: a possible antidepressant mechanism. Neuropharmacology 62, 184-191. doi: 10.1016/j.neuropharm.2011.06.017
110. Wang, Z., Liu, D., Wang, J., Liu, S., Gao, M., Ling, E.-A., et al. (2012). Cytoprotective effects of melatonin on astroglial cells subjected to palmitic acid treatment in vitro. J. Pineal Res. 52, 253-264. doi: 10.1111/j.1600-079X.2011.00952.x
111. Wergeland, S., Torkildsen, Ø., Bø, L., and Myhr, K.-M. (2012). Polyunsaturated fatty acids in multiple sclerosis therapy. Acta Neurol. Scand. Suppl. 126, 70-75. doi: 10.1111/ane.12034
112. Willis, S., Samala, R., Rosenberger, T. A., and Borges, K. (2009). Eicosapentaenoic and docosahexaenoic acids are not anticonvulsant or neuroprotective in acute mouse seizure models. Epilepsia 50, 138-142. doi: 10.1111/j.1528-1167.2008.01722.x
113. Wu, A, Ying, Z., and Gomez-Pinilla, F. (2008). Docosahexaenoic acid dietary supplementation enhances the effects of exercise on synaptic plasticity and cognition. Neuroscience 155, 751-759. doi: 10.1016/j.neuroscience.2008.05.061
114. Wu, A., Ying, Z., and Gomez-Pinilla, F. (2011). The salutary effects of DHA dietary supplementation on cognition, neuroplasticity, and membrane homeostasis after brain trauma. J. Neurotrauma 28, 2113-2122. doi: 10.1089/neu.2011.1872
115. Yakunin, E., Loeb, V., Kisos, H., Biala, Y., Yehuda, S., Yaari, Y., et al. (2012). A-synuclein neuropathology is controlled by nuclear hormone receptors and enhanced by docosahexaenoic acid in a mouse model for Parkinson's disease. Brain Pathol. 22, 280-294. doi: 10.1111/j.1750-3639.2011.00530.x
116. Yamashima, T. (2012). "PUFA-GPR40-CREB signaling" hypothesis for the adult primate neurogenesis. Prog. Lipid Res. 51, 221-231. doi: 10.1016/j.plipres.2012.02.001
117. Yang, H., Zhuo, J.-M., Chu, J., Chinnici, C., and Praticò, D. (2010). Amelioration of the Alzheimer's disease phenotype by absence of 12/15-lipoxygenase. Biol. Psychiatry 68, 922-929. doi: 10.1016/j.biopsych.2010.04.010
118. Yee, P., Weymouth, A. E., Fletcher, E. L., and Vingrys, A. J. (2010). A role for omega-3 polyunsaturated fatty acid supplements in diabetic neuropathy. Invest. Ophthalmol. Vis. Sci.51, 1755-1764. doi: 10.1167/iovs.09-3792
119. Yip, P. K., Pizzasegola, C., Gladman, S., Biggio, M. L., Marino, M., Jayasinghe, M., et al. (2013). The omega-3 fatty acid eicosapentaenoic acid accelerates disease progression in a model of amyotrophic lateral sclerosis. PLoS ONE 8:e61626. doi: 10.1371/journal.pone.0061626
120. Yu, H., Bi, Y., Ma, W., He, L., Yuan, L., Feng, J., et al. (2010). Long-term effects of high lipid and high energy diet on serum lipid, brain fatty acid composition, and memory and learning ability in mice. Int. J. Dev. Neurosci. 28, 271-276. doi: 10.1016/j.ijdevneu.2009.12.001
121. Zhang, C., and Bazan, N. G. (2010). Lipid-mediated cell signaling protects against injury and neurodegeneration. J. Nutr. 140, 858-863. doi: 10.3945/jn.109.114884
122. Zhang, W., Hu, X., Yang, W., Gao, Y., and Chen, J. (2010). Omega-3 polyunsaturated fatty acid supplementation confers long-term neuroprotection against neonatal hypoxic-ischemic brain injury through anti-inflammatory actions. Stroke 41, 2341-2347. doi: 10.1161/STROKEAHA.110.586081
123. Zhao, C.-H., Liu, H.-Q., Cao, R., Ji, A.-L., Zhang, L., Wang, F., et al. (2012). Effects of dietary fish oil on learning function and apoptosis of hippocampal pyramidal neurons in streptozotocin-diabetic rats. Brain Res. 1457, 33-43. doi: 10.1016/j.brainres.2012.03.067
124. Zhou, Y., Zhang, Y., Li, J., Lv, F., Zhao, Y., Duan, D., et al. (2012). A comprehensive study on long-term injury to nigral dopaminergic neurons following intracerebroventricular injection of lipopolysaccharide in rats. J. Neurochem. 123, 771-780. doi: 10.1111/jnc.12010