2-Decenoic acid ethyl ester, a derivative of unsaturated medium-chain fatty acids, facilitates functional recovery of locomotor activity after spinal cord injury

Neuroscience

Volumn 171, Issue 4, 2010, Pages 1377-1385

  Hirakawa, A ^a,b   Shimizu, K ^b   Fukumitsu, H ^a   Soumiya, H ^a   Iinuma, M ^a   Furukawa, S ^a  

^a GIFU PHARMACEUTICAL UNIVERSITY   (Japan)

^b GIFU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Bcl 2; BDNF; ERK1 2; Secondary damage

Indexed keywords

2 DECENOIC ACID ETHYL ESTER; BRAIN DERIVED NEUROTROPHIC FACTOR; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEIN BCL 2; UNCLASSIFIED DRUG; UNSATURATED FATTY ACID;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; CONVALESCENCE; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; FEMALE; LOCOMOTION; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RAT; SPINAL CORD HEMISECTION; SPINAL CORD INJURY; SPINAL CORD NERVE CELL;

ANALYSIS OF VARIANCE; ANIMALS; BRAIN-DERIVED NEUROTROPHIC FACTOR; CELLS, CULTURED; CEREBRAL CORTEX; DISEASE MODELS, ANIMAL; EMBRYO, MAMMALIAN; FATTY ACIDS, MONOUNSATURATED; FATTY ACIDS, UNSATURATED; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GLIAL FIBRILLARY ACIDIC PROTEIN; MITOGEN-ACTIVATED PROTEIN KINASE 3; MOTOR ACTIVITY; NEURONS; PHOSPHOPYRUVATE HYDRATASE; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-BCL-2; RATS; RATS, WISTAR; RECOVERY OF FUNCTION; RNA, MESSENGER; SPINAL CORD INJURIES;

EID: 78650170728     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2010.10.004     Document Type: Article

References (50)

1. Basso D.M., Beattie M.S., Bresnahan J.C. Graded histological and locomotor outcomes after spinal cord contusion using the NYU weight-drop device versus transection. Exp Neurol 1996, 139:244-256.
2. Bhat N.R., Zhang P., Lee J.C., Hogan E.L. Extracellular signal-regulated kinase and p38 subgroups of mitogen-activated protein kinases regulate inducible nitric oxide synthase and tumor necrosis factor-alpha gene expression in endotoxin-stimulated primary glial cultures. J Neurosci 1998, 18:1633-1641.
3. Blondeau N., Widmann C., Lazdunski M., Heurteaux C. Polyunsaturated fatty acids induce ischemic and epileptic tolerance. Neuroscience 2002, 109:231-241.
4. Bonni A., Brunet A., West A.E., Datta S.R., Takasu M.A., Greenberg M.E. Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms. Science 1999, 286:1358-1362.
5. Boyce V.S., Tumolo M., Fischer I., Murray M., Lemay M.A. Neurotrophic factors promote and enhance locomotor recovery in untrained spinalized cats. J Neurophysiol 2007, 98:1988-1996.
6. Choi D.W. Ionic dependence of glutamate neurotoxicity. J Neurosci 1987, 7:369-379.
7. Ding Q., Wang Q., Deng J., Gu Q., Hu S., Li Y., Su B., Zeng Y., Xiong L. Sevoflurane preconditioning induces rapid ischemic tolerance against spinal cord ischemia/reperfusion through activation of extracellular signal-regulated kinase in rabbits. Anesth Analg 2009, 109:1263-1272.
8. Emsley R., Oosthuizen P., van Rensburg S.J. Clinical potential of omega-3 fatty acids in the treatment of schizophrenia. CNS Drugs 2003, 17:1081-1091.
9. Faden A.I., Simon R.P. A potential role for excitotoxins in the pathophysiology of spinal cord injury. Ann Neurol 1988, 23:623-626.
10. Ferchmin P.A., Perez D., Eterovic V.A., de Vellis J. Nicotinic receptors differentially regulate N-methyl-[scap]d]-aspartate damage in acute hippocampal slices. J Pharmacol Exp Ther 2003, 305:1071-1078.
11. Genovese T., Rossi A., Mazzon E., Di Paola R., Muia C., Caminiti R., Bramanti P., Sautebin L., Cuzzocrea S. Effects of zileuton and montelukast in mouse experimental spinal cord injury. Br J Pharmacol 2008, 153:568-582.
12. Hajebrahimi Z., Mowla S.J., Movahedin M., Tavallaei M. Gene expression alterations of neurotrophins, their receptors and prohormone convertases in a rat model of spinal cord contusion. Neurosci Lett 2008, 441:261-266.
13. Hashimoto M., Nitta A., Fukumitsu H., Nomoto H., Shen L., Furukawa S. Inflammation-induced GDNF improves locomotor function after spinal cord injury. Neuroreport 2005, 16:99-102.
14. Hashimoto M., Sun D., Rittling S.R., Denhardt D.T., Young W. Osteopontin-deficient mice exhibit less inflammation, greater tissue damage, and impaired locomotor recovery from spinal cord injury compared with wild-type controls. J Neurosci 2007, 27:3603-3611.
15. Hattori N., Nomoto H., Fukumitsu H., Mishima S., Furukawa S. Royal jelly-induced neurite outgrowth from rat pheochromocytoma PC12 cells requires integrin signal independent of activation of extracellular signal-regulated kinases. Biomed Res 2007, 28:139-146.
16. Hayashi M., Ueyama T., Nemoto K., Tamaki T., Senba E. Sequential mRNA expression for immediate early genes, cytokines, and neurotrophins in spinal cord injury. J Neurotrauma 2000, 17:203-218.
17. Hetman M., Gozdz A. Role of extracellular signal regulated kinases 1 and 2 in neuronal survival. Eur J Biochem 2004, 271:2050-2055.
18. Huang W.L., King V.R., Curran O.E., Dyall S.C., Ward R.E., Lal N., Priestley J.V., Michael-Titus A.T. A combination of intravenous and dietary docosahexaenoic acid significantly improves outcome after spinal cord injury. Brain 2007, 130:3004-3019.
19. Ikeda O., Murakami M., Ino H., Yamazaki M., Koda M., Nakayama C., Moriya H. Effects of brain-derived neurotrophic factor (BDNF) on compression-induced spinal cord injury: BDNF attenuates down-regulation of superoxide dismutase expression and promotes up-regulation of myelin basic protein expression. J Neuropathol Exp Neurol 2002, 61:142-153.
20. Jover-Mengual T., Zukin R.S., Etgen A.M. MAPK signaling is critical to estradiol protection of CA1 neurons in global ischemia. Endocrinology 2007, 148:1131-1143.
21. Kamata Y., Shiraga H., Tai A., Kawamoto Y., Gohda E. Induction of neurite outgrowth in PC12 cells by the medium-chain fatty acid octanoic acid. Neuroscience 2007, 146:1073-1081.
22. Kane D.J., Ord T., Anton R., Bredesen D.E. Expression of bcl-2 inhibits necrotic neural cell death. J Neurosci Res 1995, 40:269-275.
23. Kane D.J., Sarafian T.A., Anton R., Hahn H., Gralla E.B., Valentine J.S., Ord T., Bredesen D.E. Bcl-2 inhibition of neural death: decreased generation of reactive oxygen species. Science 1993, 262:1274-1277.
24. King V.R., Huang W.L., Dyall S.C., Curran O.E., Priestley J.V., Michael-Titus A.T. Omega-3 fatty acids improve recovery, whereas omega-6 fatty acids worsen outcome, after spinal cord injury in the adult rat. J Neurosci 2006, 26:4672-4680.
25. Kobayashi N.R., Fan D.P., Giehl K.M., Bedard A.M., Wiegand S.J., Tetzlaff W. BDNF and NT-4/5 prevent atrophy of rat rubrospinal neurons after cervical axotomy, stimulate GAP-43 and Talpha1-tubulin mRNA expression, and promote axonal regeneration. J Neurosci 1997, 17:9583-9595.
26. Lang-Lazdunski L., Blondeau N., Jarretou G., Lazdunski M., Heurteaux C. Linolenic acid prevents neuronal cell death and paraplegia after transient spinal cord ischemia in rats. J Vasc Surg 2003, 38:564-575.
27. Lauritzen I., Blondeau N., Heurteaux C., Widmann C., Romey G., Lazdunski M. Polyunsaturated fatty acids are potent neuroprotectors. EMBO J 2000, 19:1784-1793.
28. Liu D., Thangnipon W., McAdoo D.J. Excitatory amino acids rise to toxic levels upon impact injury to the rat spinal cord. Brain Res 1991, 547:344-348.
29. Lou J., Lenke L.G., Xu F., O'Brien M. In vivo] Bcl-2 oncogene neuronal expression in the rat spinal cord. Spine (Phila Pa 1976) 1998, 23:517-523.
30. Lu P., Jones L.L., Tuszynski M.H. BDNF-expressing marrow stromal cells support extensive axonal growth at sites of spinal cord injury. Exp Neurol 2005, 191:344-360.
31. Mitsui T., Fischer I., Shumsky J.S., Murray M. Transplants of fibroblasts expressing BDNF and NT-3 promote recovery of bladder and hindlimb function following spinal contusion injury in rats. Exp Neurol 2005, 194:410-431.
32. Ohmiya M., Shudai T., Nitta A., Nomoto H., Furukawa Y., Furukawa S. Brain-derived neurotrophic factor alters cell migration of particular progenitors in the developing mouse cerebral cortex. Neurosci Lett 2002, 317:21-24.
33. Pearson G., Robinson F., Beers Gibson T., Xu B.E., Karandikar M., Berman K., Cobb M.H. Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions. Endocr Rev 2001, 22:153-183.
34. Polster B.M., Fiskum G. Mitochondrial mechanisms of neural cell apoptosis. J Neurochem 2004, 90:1281-1289.
35. Sayer F.T., Oudega M., Hagg T. Neurotrophins reduce degeneration of injured ascending sensory and corticospinal motor axons in adult rat spinal cord. Exp Neurol 2002, 175:282-296.
36. Seki T., Hida K., Tada M., Koyanagi I., Iwasaki Y. Role of the bcl-2 gene after contusive spinal cord injury in mice. Neurosurgery 2003, 53:192-198.
37. Shibata M., Murray M., Tessler A., Ljubetic C., Connors T., Saavedra R.A. Single injections of a DNA plasmid that contains the human Bcl-2 gene prevent loss and atrophy of distinct neuronal populations after spinal cord injury in adult rats. Neurorehabil Neural Repair 2000, 14:319-330.
38. Singer C.A., Figueroa-Masot X.A., Batchelor R.H., Dorsa D.M. The mitogen-activated protein kinase pathway mediates estrogen neuroprotection after glutamate toxicity in primary cortical neurons. J Neurosci 1999, 19:2455-2463.
39. Takahashi K., Schwarz E., Ljubetic C., Murray M., Tessler A., Saavedra R.A. DNA plasmid that codes for human Bcl-2 gene preserves axotomized Clarke's nucleus neurons and reduces atrophy after spinal cord hemisection in adult rats. J Comp Neurol 1999, 404:159-171.
40. Takei N., Tanaka O., Endo Y., Lindholm D., Hatanaka H. BDNF and NT-3 but not CNTF counteract the Ca2+ ionophore-induced apoptosis of cultured cortical neurons: involvement of dual pathways. Neuropharmacology 1999, 38:283-288.
41. Thoenen H. Neurotrophins and neuronal plasticity. Science 1995, 270:593-598.
42. Toborek M., Son K.W., Pudelko A., King-Pospisil K., Wylegala E., Malecki A. ERK 1/2 signaling pathway is involved in nicotine-mediated neuroprotection in spinal cord neurons. J Cell Biochem 2007, 100:279-292.
43. Vavrek R., Girgis J., Tetzlaff W., Hiebert G.W., Fouad K. BDNF promotes connections of corticospinal neurons onto spared descending interneurons in spinal cord injured rats. Brain 2006, 129:1534-1545.
44. Wang Z.Q., Wu D.C., Huang F.P., Yang G.Y. Inhibition of MEK/ERK 1/2 pathway reduces pro-inflammatory cytokine interleukin-1 expression in focal cerebral ischemia. Brain Res 2004, 996:55-66.
45. Yan Q., Matheson C., Lopez O.T., Miller J.A. The biological responses of axotomized adult motoneurons to brain-derived neurotrophic factor. J Neurosci 1994, 14:5281-5291.
46. Yanase M., Sakou T., Fukuda T. Role of N-methyl-[scap]d]-aspartate receptor in acute spinal cord injury. J Neurosurg 1995, 83:884-888.
47. Yukawa Y., Lou J., Fukui N., Lenke L.G. Optimal treatment timing to attenuate neuronal apoptosis via Bcl-2 gene transfer in vitro] and in vivo]. J Neurotrauma 2002, 19:1091-1103.
48. Yune T.Y., Park H.G., Lee J.Y., Oh T.H. Estrogen-induced Bcl-2 expression after spinal cord injury is mediated through phosphoinositide-3-kinase/Akt-dependent CREB activation. J Neurotrauma 2008, 25:1121-1131.
49. Zhong L.T., Kane D.J., Bredesen D.E. BCL-2 blocks glutamate toxicity in neural cell lines. Brain Res Mol Brain Res 1993, 19:353-355.
50. Zhong L.T., Sarafian T., Kane D.J., Charles A.C., Mah S.P., Edwards R.H., Bredesen D.E. Bcl-2 inhibits death of central neural cells induced by multiple agents. Proc Natl Acad Sci U S A 1993, 90:4533-4537.