The role of 5-HT 1A receptors in fish oil-mediated increased BDNF expression in the rat hippocampus and cortex: A possible antidepressant mechanism

Neuropharmacology

Volumn 62, Issue 1, 2012, Pages 184-191

  Vines, Aparecida ^a   Delattre, Ana Marcia ^a   Lima, Marcelo M S ^a   Rodrigues, Laís Soares ^a   Suchecki, Deborah ^b   MacHado, Ricardo B ^b   Tufik, Sergio ^b   Pereira, Sofia I R ^a   Zanata, Sílvio M ^a   Ferraz, Anete Curte ^a  

^a FEDERAL UNIVERSITY OF PARANÁ   (Brazil)

^b FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

5 HT 1A receptors; BDNF; Depression; Fish oil; Polyunsaturated fatty acids; Serotonin

Indexed keywords

3,4 DIHYDROXYPHENYLACETIC ACID; 5 HYDROXYINDOLEACETIC ACID; BRAIN DERIVED NEUROTROPHIC FACTOR; FISH OIL; OMEGA 3 FATTY ACID; SEROTONIN 1A RECEPTOR;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; BRAIN CORTEX; BRAIN REGION; CONFERENCE PAPER; CONTROLLED STUDY; DIET SUPPLEMENTATION; FEMALE; FORCED SWIMMING TEST; HIPPOCAMPUS; MOUSE; NEUROTRANSMISSION; NONHUMAN; OPEN FIELD TEST; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SEROTONINERGIC SYSTEM;

ANALYSIS OF VARIANCE; ANIMALS; BRAIN-DERIVED NEUROTROPHIC FACTOR; CEREBRAL CORTEX; DEPRESSION; DISEASE MODELS, ANIMAL; EXPLORATORY BEHAVIOR; FATTY ACIDS, OMEGA-3; FEMALE; FENCLONINE; HIPPOCAMPUS; IMMOBILITY RESPONSE, TONIC; MALE; MOTOR ACTIVITY; NEUROCHEMISTRY; PIPERAZINES; RATS; RATS, WISTAR; RECEPTOR, SEROTONIN, 5-HT1A; SEROTONIN ANTAGONISTS; SWIMMING;

EID: 80054095577     PISSN: 00283908     EISSN: 18737064     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2011.06.017     Document Type: Conference Paper

References (64)

1. 1A receptor gene expression as a new target for antidepressant therapy Front. Neurosci. 4 2010 35
2. C.A. Altar, R.E. Whitehead, R. Chen, G. Wortwein, and T.M. Madsen Effects of electroconvulsive seizures and antidepressant drugs on brain-derived neurotrophic factor protein in rat brain Biol. Psychiatry 54 2003 703 709 (Pubitemid 37281386)
3. D.T. Balu, B.A. Hoshaw, J.E. Malberg, S. Rosenzweig-Lipson, L.E. Schechter, and I. Lucki Differential regulation of central BDNF protein levels by antidepressant and non-antidepressant drug treatments Brain Res. 1211 2008 37 43
4. L.M. Bodnar, and K.L. Wisner Nutrition and depression: implications for improving mental health among childbearing-aged women Biol. Psychiatry 58 2005 679 685 (Pubitemid 41547234)
5. E.C. Borsonelo, and J.C. Galduroz The role of polyunsaturated fatty acids (PUFAs) in development, aging and substance abuse disorders: review and propositions Prostaglandins Leukot. Essent. Fatty Acids 78 2008 237 245 (Pubitemid 351794238)
6. J.M. Bourre Dietary omega-3 fatty acids for women Biomed. Pharmacother. 61 2007 105 112
7. P.L. Broadhurst Experiments in psychogenetics H.J. Einsenk, Experiments in Personality 1960 Routledge and Kegan Paul London 52 71
8. L. Cervo, G. Grignaschi, C. Rossi, and R. Samanin Role of central serotonergic neurons in the effect of sertraline in rats in the forced swimming test Eur. J. Pharmacol. 196 1991 217 222
9. M.S. Clark, and J.F. Neumaier The 5-HT1B receptor: behavioral implications Psychopharmacol. Bull. 35 2001 170 185
10. L.A. Colangelo, K. He, M.A. Whooley, M.L. Daviglus, and K. Liu Higher dietary intake of long-chain omega-3 polyunsaturated fatty acids is inversely associated with depressive symptoms in women Nutrition 25 2009 1011 1019
11. T.I. Cremers, K. Rea, F.J. Bosker, H.V. Wikstrom, S. Hogg, A. Mork, and B.H. Westerink Augmentation of SSRI effects on serotonin by 5-HT2C antagonists: mechanistic studies Neuropsychopharmacology 32 2007 1550 1557 (Pubitemid 46920163)
12. J.F. Cryan, M.E. Page, and I. Lucki Noradrenergic lesions differentially alter the antidepressant-like effects of reboxetine in a modified forced swim test Eur. J. Pharmacol. 436 2002 197 205 (Pubitemid 34164699)
13. J.F. Cryan, R.J. Valentino, and I. Lucki Assessing substrates underlying the behavioral effects of antidepressants using the modified rat forced swimming test Neurosci. Biobehav Rev. 29 2005 547 569 (Pubitemid 40755456)
14. T.M. Da Silva, R.P. Munhoz, C. Alvarez, K. Naliwaiko, A. Kiss, R. Andreatini, and A.C. Ferraz Depression in Parkinson's disease: a double-blind, randomized, placebo-controlled pilot study of omega-3 fatty-acid supplementation J. Affect Disord. 111 2008 351 359
15. C. Davidson, M. Ho, G.W. Price, B.J. Jones, and J.A. Stamford (+)-WAY 100135, a partial agonist, at native and recombinant 5-HT1B/1D receptors Br. J. Pharmacol. 121 1997 737 742 (Pubitemid 27260778)
16. S. Delion, S. Chalon, D. Guilloteau, B. Lejeune, J.C. Besnard, and G. Durand Age-related changes in phospholipid fatty acid composition and monoaminergic neurotransmission in the hippocampus of rats fed a balanced or an n-3 polyunsaturated fatty acid-deficient diet J. Lipid Res. 38 1997 680 689 (Pubitemid 27194919)
17. M.J. Detke, M. Rickels, and I. Lucki Active behaviors in the rat forced swimming test differentially produced by serotonergic and noradrenergic antidepressants Psychopharmacology (Berl.) 121 1995 66 72
18. A. Eilander, D.C. Hundscheid, S.J. Osendarp, C. Transler, and P.L. Zock Effects of n-3 long chain polyunsaturated fatty acid supplementation on visual and cognitive development throughout childhood: a review of human studies Prostaglandins Leukot. Essent. Fatty Acids 76 2007 189 203 (Pubitemid 46613865)
19. B. Elfving, P.H. Plougmann, and G. Wegener Detection of brain-derived neurotrophic factor (BDNF) in rat blood and brain preparations using ELISA: pitfalls and solutions J. Neurosci. Methods 187 2010 73 77
20. E. Farkas, M.C. De Wilde, A.J. Kiliaan, J. Meijer, J.N. Keijser, and P.G. Luiten Dietary long chain PUFAs differentially affect hippocampal muscarinic 1 and serotonergic 1A receptors in experimental cerebral hypoperfusion Brain Res. 954 2002 32 41 (Pubitemid 35230003)
21. A.C. Ferraz, A.M. Delattre, R.G. Almendra, M. Sonagli, C. Borges, P. Araujo, M.L. Andersen, S. Tufik, and M.M. Lima Chronic omega-3 fatty acids supplementation promotes beneficial effects on anxiety, cognitive and depressive-like behaviors in rats subjected to a restraint stress protocol Behav. Brain Res. 219 2011 116 122
22. A.C. Ferraz, A. Kiss, R.L. Araujo, H.M. Salles, K. Naliwaiko, J. Pamplona, and F. Matheussi The antidepressant role of dietary long-chain polyunsaturated n-3 fatty acids in two phases in the developing brain Prostaglandins Leukot. Essent. Fatty Acids 78 2008 183 188 (Pubitemid 351514912)
23. D.W. Gallager, and G.K. Aghajanian Effect of antipsychotic drugs on the firing of dorsal raphe cells. II. Reversal by picrotoxin Eur. J. Pharmacol. 39 1976 357 364
24. A.M. Gardier, D.J. David, G. Jego, C. Przybylski, C. Jacquot, S. Durier, B. Gruwez, E. Douvier, P. Beauverie, N. Poisson, R. Hen, and M. Bourin Effects of chronic paroxetine treatment on dialysate serotonin in 5-HT1B receptor knockout mice J. Neurochem. 86 2003 13 24 (Pubitemid 36753841)
25. C. Gundlah, S. Hjorth, and S.B. Auerbach Autoreceptor antagonists enhance the effect of the reuptake inhibitor citalopram on extracellular 5-HT: this effect persists after repeated citalopram treatment Neuropharmacology 36 1997 475 482 (Pubitemid 27272093)
26. L. Gunther, J. Rothe, A. Rex, J.P. Voigt, M.J. Millan, H. Fink, and B. Bert 5-HT(1A)-receptor over-expressing mice: genotype and sex dependent responses to antidepressants in the forced swim-test Neuropharmacology 2011
27. E. Hajos-Korcsok, S.F. Mctavish, and T. Sharp Effect of a selective 5-hydroxytryptamine reuptake inhibitor on brain extracellular noradrenaline: microdialysis studies using paroxetine Eur. J. Pharmacol. 407 2000 101 107
28. A. Harkin, T.J. Connor, M. Walsh, N. St John, and J.P. Kelly Serotonergic mediation of the antidepressant-like effects of nitric oxide synthase inhibitors Neuropharmacology 44 2003 616 623 (Pubitemid 36369141)
29. I. Hervas, C.M. Queiroz, A. Adell, and F. Artigas Role of uptake inhibition and autoreceptor activation in the control of 5-HT release in the frontal cortex and dorsal hippocampus of the rat Br. J. Pharmacol. 130 2000 160 166 (Pubitemid 30248440)
30. D. Hoyer, D.E. Clarke, J.R. Fozard, P.R. Hartig, G.R. Martin, E.J. Mylecharane, P.R. Saxena, and P.P. Humphrey International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (Serotonin) Pharmacol. Rev. 46 1994 157 203 (Pubitemid 24185150)
31. S.M. Innis The role of dietary n-6 and n-3 fatty acids in the developing brain Dev. Neurosci. 22 2000 474 480
32. J.P. Jacobsen, and A. Mork The effect of escitalopram, desipramine, electroconvulsive seizures and lithium on brain-derived neurotrophic factor mRNA and protein expression in the rat brain and the correlation to 5-HT and 5-HIAA levels Brain Res. 1024 2004 183 192 (Pubitemid 39286729)
33. M.E. Keck, S.B. Sartori, T. Welt, M.B. Muller, F. Ohl, F. Holsboer, R. Landgraf, and N. Singewald Differences in serotonergic neurotransmission between rats displaying high or low anxiety/depression-like behaviour: effects of chronic paroxetine treatment J. Neurochem. 92 2005 1170 1179 (Pubitemid 40344307)
34. A.B. Klein, M.A. Santini, S. Aznar, G.M. Knudsen, and M. Rios Changes in 5-HT2A-mediated behavior and 5-HT2A- and 5-HT1A receptor binding and expression in conditional brain-derived neurotrophic factor knock-out mice Neuroscience 169 2010 1007 1016
35. D.S. Kreiss, and I. Lucki Effects of acute and repeated administration of antidepressant drugs on extracellular levels of 5-hydroxytryptamine measured in vivo J. Pharmacol. Exp. Ther. 274 1995 866 876
36. B. Levant, M.K. Ozias, P.F. Davis, M. Winter, K.L. Russell, S.E. Carlson, G.A. Reed, and K.E. Mccarson Decreased brain docosahexaenoic acid content produces neurobiological effects associated with depression: interactions with reproductive status in female rats Psychoneuroendocrinology 33 2008 1279 1292
37. M.M.S. Lima, A. Braga Reksidler, S. Marques Zanata, H. Bueno Machado, S. Tufik, and M.A. Vital Different parkinsonism models produce a time-dependent induction of COX-2 in the substantia nigra of rats Brain Res. 1101 2006 117 125 (Pubitemid 44036768)
38. I. Lucki The forced swimming test as a model for core and component behavioral effects of antidepressant drugs Behav. Pharmacol. 8 1997 523 532 (Pubitemid 27504702)
39. R.B. Machado, S. Tufik, and D. Suchecki Chronic stress during paradoxical sleep deprivation increases paradoxical sleep rebound: association with prolactin plasma levels and brain serotonin content Psychoneuroendocrinology 33 2008 1211 1224
40. K. Martinowich, and B. Lu Interaction between BDNF and serotonin: role in mood disorders Neuropsychopharmacology 33 2008 73 83 (Pubitemid 350191318)
41. R.K. Mcnamara, J. Able, Y. Liu, R. Jandacek, T. Rider, P. Tso, and J.W. Lipton Omega-3 fatty acid deficiency during perinatal development increases serotonin turnover in the prefrontal cortex and decreases midbrain tryptophan hydroxylase-2 expression in adult female rats: dissociation from estrogenic effects J. Psychiatr. Res. 43 2009 656 663
42. R.K. Mcnamara, and S.E. Carlson Role of omega-3 fatty acids in brain development and function: potential implications for the pathogenesis and prevention of psychopathology Prostaglandins Leukot. Essent. Fatty Acids 75 2006 329 349 (Pubitemid 44442917)
43. K. Naliwaiko, R.L. Araujo, R.V. Da Fonseca, J.C. Castilho, R. Andreatini, M.I. Bellissimo, B.H. Oliveira, E.F. Martins, R. Curi, L.C. Fernandes, and A.C. Ferraz Effects of fish oil on the central nervous system: a new potential antidepressant? Nutr. Neurosci. 7 2004 91 99 (Pubitemid 38961729)
44. E.J. Nestler, M. Barrot, R.J. Dileone, A.J. Eisch, S.J. Gold, and L.M. Monteggia Neurobiology of depression Neuron 34 2002 13 25 (Pubitemid 34270695)
45. M.E. Page, M.J. Detke, A. Dalvi, L.G. Kirby, and I. Lucki Serotonergic mediation of the effects of fluoxetine, but not desipramine, in the rat forced swimming test Psychopharmacology (Berl.) 147 1999 162 167 (Pubitemid 30010563)
46. A. Pazos, R. Cortes, and J.M. Palacios Quantitative autoradiographic mapping of serotonin receptors in the rat brain. II. Serotonin-2 receptors Brain Res. 346 1985 231 249 (Pubitemid 16241112)
47. D. Popa, J. Cerdan, C. Reperant, B.P. Guiard, J.P. Guilloux, D.J. David, and A.M. Gardier A longitudinal study of 5-HT outflow during chronic fluoxetine treatment using a new technique of chronic microdialysis in a highly emotional mouse strain Eur. J. Pharmacol. 628 2010 83 90
48. R.D. Porsolt, M. Le Pichon, and M. Jalfre Depression: a new animal model sensitive to antidepressant treatments Nature 266 1977 730 732 (Pubitemid 8073804)
49. S. Riemer, M. Maes, A. Christophe, and W. Rief Lowered omega-3 PUFAs are related to major depression, but not to somatization syndrome J. Affect Disord. 123 2009 173 180
50. L. Romero, and F. Artigas Preferential potentiation of the effects of serotonin uptake inhibitors by 5-HT1A receptor antagonists in the dorsal raphe pathway: role of somatodendritic autoreceptors J. Neurochem. 68 1997 2593 2603 (Pubitemid 27218184)
51. B.M. Ross Omega-3 fatty acid deficiency in major depressive disorder is caused by the interaction between diet and a genetically determined abnormality in phospholipid metabolism Med. Hypotheses 68 2007 515 524 (Pubitemid 46043407)
52. B.M. Ruf, and Z. Bhagwagar The 5-HT1B receptor: a novel target for the pathophysiology of depression Curr. Drug Targets 10 2009 1118 1138
53. R.M. Santiago, J. Barbieiro, M.M. Lima, P.A. Dombrowski, R. Andreatini, and M.A. Vital Depressive-like behaviors alterations induced by intranigral MPTP, 6-OHDA, LPS and rotenone models of Parkinson's disease are predominantly associated with serotonin and dopamine Prog. Neuropsychopharmacol. Biol. Psychiatry 34 2010 1104 1114
54. J. Savitz, I. Lucki, and W.C. Drevets 5-HT(1A) receptor function in major depressive disorder Prog. Neurobiol. 88 2009 17 31
55. J. Serrats, G. Mengod, and R. Cortes Expression of serotonin 5-HT2C receptors in GABAergic cells of the anterior raphe nuclei J. Chem. Neuroanat. 29 2005 83 91 (Pubitemid 40126684)
56. T. Sharp, L. Boothman, J. Raley, and P. Queree Important messages in the 'post': recent discoveries in 5-HT neurone feedback control Trends Pharmacol. Sci. 28 2007 629 636 (Pubitemid 350166575)
57. P. Svenningsson, K. Chergui, I. Rachleff, M. Flajolet, X. Zhang, M. El Yacoubi, J.M. Vaugeois, G.G. Nomikos, and P. Greengard Alterations in 5-HT1B receptor function by p11 in depression-like states Science 311 2006 77 80 (Pubitemid 43063061)
58. G. Ulak, O. Mutlu, P. Tanyeri, F.I. Komsuoglu, F.Y. Akar, and B.F. Erden Involvement of serotonin receptor subtypes in the antidepressant-like effect of TRIM in the rat forced swimming test Pharmacol. Biochem. Behav. 95 2010 308 314
59. V.R. Venna, D. Deplanque, C. Allet, K. Belarbi, M. Hamdane, and R. Bordet PUFA induce antidepressant-like effects in parallel to structural and molecular changes in the hippocampus Psychoneuroendocrinology 34 2009 199 211
60. Q.P. Wang, H. Ochiai, and Y. Nakai GABAergic innervation of serotonergic neurons in the dorsal raphe nucleus of the rat studied by electron microscopy double immunostaining Brain Res. Bull. 29 1992 943 948
61. G. Wegener, Z. Bandpey, I.L. Heiberg, A. Mork, and R. Rosenberg Increased extracellular serotonin level in rat hippocampus induced by chronic citalopram is augmented by subchronic lithium: neurochemical and behavioural studies in the rat Psychopharmacology (Berl.) 166 2003 188 194 (Pubitemid 36313127)
62. S. Wieland, and I. Lucki Antidepressant-like activity of 5-HT1A agonists measured with the forced swim test Psychopharmacology (Berl.) 101 1990 497 504 (Pubitemid 20220042)
63. H. Yu, and Z. Chen The role of BDNF in depression on the basis of its location in the neuronal circuitry Acta Pharmacologica Sinica 32 2011 3 11
64. A.D.E. Zomkowski, A.O. Rosa, J. Lin, A.R.S. Santos, J.B. Calixto, and A.L.S. Rodrigues Evidence for serotonin subtypes involvement in agmatine antidepressant-like effect in the mouse forced swimming test Brain Res. 1023 2004 253 263 (Pubitemid 39221428)