Effects of eicosapentaenoic acid on synaptic plasticity, fatty acid profile and phosphoinositide 3-kinase signaling in rat hippocampus and differentiated PC12 cells

Journal of Nutritional Biochemistry

Volumn 21, Issue 4, 2010, Pages 268-277

  Kawashima, Akiko ^a   Harada, Tsuyoshi ^a   Kami, Hideaki ^a   Yano, Takashi ^a   Imada, Kazunori ^a   Mizuguchi, Kiyoshi ^a  

^a MOCHIDA PHARMACEUTICAL CO   (Japan)

Author keywords

Brain; Eicosapentaenoic acid; Long term potentiation; n 3 fatty acids; Neuron; Phosphatidylinositol 3 kinase

Indexed keywords

CASPASE 3; DOCOSAHEXAENOIC ACID; FATTY ACID; ICOSAPENTAENOIC ACID; NERVE GROWTH FACTOR; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN P85;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL DEATH; CELL DIFFERENTIATION; CELL STRAIN; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; EXCITATORY POSTSYNAPTIC POTENTIAL; GENE EXPRESSION; GLIA CELL; HIPPOCAMPUS; LEARNING; LONG TERM POTENTIATION; MALE; MEMORY CONSOLIDATION; NERVE CELL; NERVE CELL PLASTICITY; NERVE DEGENERATION; NEUROPROTECTION; NONHUMAN; RAT; SIGNAL TRANSDUCTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; BRAIN; CA1 REGION, HIPPOCAMPAL; CELL DEATH; CELL DIFFERENTIATION; DIETARY FATS; EICOSAPENTAENOIC ACID; FATTY ACIDS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HIPPOCAMPUS; LONG-TERM POTENTIATION; MALE; NEUROGLIA; NEURONAL PLASTICITY; NEURONS; PC12 CELLS; PROTO-ONCOGENE PROTEINS C-AKT; RANDOM ALLOCATION; RATS; RATS, WISTAR; RNA, MESSENGER; SIGNAL TRANSDUCTION;

RATTUS;

EID: 77949273976     PISSN: 09552863     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jnutbio.2008.12.015     Document Type: Article

References (48)

1. Horrocks L.A., and Farooqui A.A. Docosahexaenoic acid in the diet: its importance in maintenance and restoration of neural membrane function. Prostaglandins Leukot Essent Fatty Acids 70 (2004) 361-372
2. Song C., and Zhao S. Omega-3 fatty acid eicosapentaenoic acid. A new treatment for psychiatric and neurodegenerative diseases: a review of clinical investigations. Expert Opin Investig Drugs 16 (2007) 1627-1638
3. Kalmijn S., Launer L.J., Ott A., Witteman J.C., Hofman A., and Breteler M.M. Dietary fat intake and the risk of incident dementia in the Rotterdam Study. Ann Neurol 42 (1997) 776-782
4. Peet M., Brind J., Ramchand C.N., Shah S., and Vankar G.K. Two double-blind placebo-controlled pilot studies of eicosapentaenoic acid in the treatment of schizophrenia. Schizophr Res 49 (2001) 243-251
5. Stoll A.L., Severus W.E., Freeman M.P., Rueter S., Zboyan H.A., Diamond E., et al. Omega 3 fatty acids in bipolar disorder: a preliminary double-blind, placebo-controlled trial. Arch Gen Psychiatry 56 (1999) 407-412
6. Van Raamsdonk J.M., Pearson J., Rogers D.A., Lu G., Barakauskas V.E., Barr A.M., et al. Ethyl-EPA treatment improves motor dysfunction, but not neurodegeneration in the YAC128 mouse model of Huntington disease. Exp Neurol 196 (2005) 266-272
7. Moore S.A., Yoder E., Murphy S., Dutton G.R., and Spector A.A. Astrocytes, not neurons, produce docosahexaenoic acid (22:6 omega-3) and arachidonic acid (20:4 omega-6). J Neurochem 56 (1991) 518-524
8. Igarashi M., Ma K., Chang L., Bell J.M., and Rapoport S.I. Dietary n-3 PUFA deprivation for 15 weeks upregulates elongase and desaturase expression in rat liver but not brain. J Lipid Res 48 (2007) 2463-2470
9. Lefkowitz W., Lim S.Y., Lin Y., and Salem Jr. N. Where does the developing brain obtain its docosahexaenoic acid? Relative contributions of dietary alpha-linolenic acid, docosahexaenoic acid, and body stores in the developing rat. Pediatr Res 57 (2005) 157-165
10. Scott B.L., and Bazan N.G. Membrane docosahexaenoate is supplied to the developing brain and retina by the liver. Proc Natl Acad Sci U S A 86 (1989) 2903-2907
11. Moore S.A., Yoder E., and Spector A.A. Role of the blood-brain barrier in the formation of long-chain omega-3 and omega-6 fatty acids from essential fatty acid precursors. J Neurochem 55 (1990) 391-402
12. Petroni A., Salami M., Blasevich M., Papini N., and Galli C. Inhibition by n-3 fatty acids of arachidonic acid metabolism in a primary culture of astroglial cells. Neurochem Res 19 (1994) 1187-1193
13. Young G., and Conquer J. Omega-3 fatty acids and neuropsychiatric disorders. Reprod Nutr Dev 45 (2005) 1-28
14. Lonergan P.E., Martin D.S., Horrobin D.F., and Lynch M.A. Neuroprotective effect of eicosapentaenoic acid in hippocampus of rats exposed to gamma-irradiation. J Biol Chem 277 (2002) 20804-20811
15. Martin D.S., Spencer P., Horrobin D.F., and Lynch M.A. Long-term potentiation in aged rats is restored when the age-related decrease in polyunsaturated fatty acid concentration is reversed. Prostaglandins Leukot Essent Fatty Acids 67 (2002) 121-130
16. Minogue A.M., Lynch A.M., Loane D.J., Herron C.E., and Lynch M.A. Modulation of amyloid-beta-induced and age-associated changes in rat hippocampus by eicosapentaenoic acid. J Neurochem 103 (2007) 914-926
17. Dyall S.C., Michael G.J., Whelpton R., Scott A.G., and Michael-Titus A.T. Dietary enrichment with omega-3 polyunsaturated fatty acids reverses age-related decreases in the GluR2 and NR2B glutamate receptor subunits in rat forebrain. Neurobiol Aging 28 (2007) 424-439
18. Gerbi A., Zerouga M., Debray M., Durand G., Chanez C., and Bourre J.M. Effect of fish oil diet on fatty acid composition of phospholipids of brain membranes and on kinetic properties of Na+,K(+)-ATPase isoenzymes of weaned and adult rats. J Neurochem 62 (1994) 1560-1569
19. Kim H.Y. Novel metabolism of docosahexaenoic acid in neural cells. J Biol Chem 282 (2007) 18661-18665
20. Wu A., Ying Z., and Gomez-Pinilla F. Dietary omega-3 fatty acids normalize BDNF levels, reduce oxidative damage, and counteract learning disability after traumatic brain injury in rats. J Neurotrauma 21 (2004) 1457-1467
21. Gamoh S., Hashimoto M., Sugioka K., Shahdat Hossain M., Hata N., Misawa Y., et al. Chronic administration of docosahexaenoic acid improves reference memory-related learning ability in young rats. Neuroscience 93 (1999) 237-241
22. Oka H., Shimono K., Ogawa R., Sugihara H., and Taketani M. A new planar multielectrode array for extracellular recording: application to hippocampal acute slice. J Neurosci Methods 93 (1999) 61-67
23. Larson J., Wong D., and Lynch G. Patterned stimulation at the theta frequency is optimal for the induction of hippocampal long-term potentiation. Brain Res 368 (1986) 347-350
24. Du K., and Montminy M. CREB is a regulatory target for the protein kinase Akt/PKB. J Biol Chem 273 (1998) 32377-32379
25. Calon F., Lim G.P., Yang F., Morihara T., Teter B., Ubeda O., et al. Docosahexaenoic acid protects from dendritic pathology in an Alzheimer's disease mouse model. Neuron 43 (2004) 633-645
26. Gerster H. Can adults adequately convert alpha-linolenic acid (18:3n-3) to eicosapentaenoic acid (20:5n-3) and docosahexaenoic acid (22:6n-3)?. Int J Vitam Nutr Res 68 (1998) 159-173
27. Moore S.A. Polyunsaturated fatty acid synthesis and release by brain-derived cells in vitro. J Mol Neurosci 16 (2001) 195-200 [discussion 15-21]
28. Pawlosky R.J., Hibbeln J.R., Novotny J.A., and Salem Jr. N. Physiological compartmental analysis of alpha-linolenic acid metabolism in adult humans. J Lipid Res 42 (2001) 1257-1265
29. Langelier B., Alessandri J.M., Perruchot M.H., Guesnet P., and Lavialle M. Changes of the transcriptional and fatty acid profiles in response to n-3 fatty acids in SH-SY5Y neuroblastoma cells. Lipids 40 (2005) 719-728
30. Goustard-Langelier B., Alessandri J.M., Raguenez G., Durand G., and Courtois Y. Phospholipid incorporation and metabolic conversion of n-3 polyunsaturated fatty acids in the Y79 retinoblastoma cell line. J Neurosci Res 60 (2000) 678-685
31. Langelier B., Furet J.P., Perruchot M.H., and Alessandri J.M. Docosahexaenoic acid membrane content and mRNA expression of acyl-CoA oxidase and of peroxisome proliferator-activated receptor-delta are modulated in Y79 retinoblastoma cells differently by low and high doses of alpha-linolenic acid. J Neurosci Res 74 (2003) 134-141
32. Haag M. Essential fatty acids and the brain. Can J Psychiatry 48 (2003) 195-203
33. Youdim K.A., Martin A., and Joseph J.A. Essential fatty acids and the brain: possible health implications. Int J Dev Neurosci 18 (2000) 383-399
34. 2 in production of amyloid-beta peptides both in vitro and in vivo. J Biol Chem 282 (2007) 32676-32688
35. 2 EP2 receptor reduces oxidative damage and amyloid burden in a model of Alzheimer's disease. J Neurosci 25 (2005) 10180-10187
36. 2 receptor subtype 2 (EP2) regulates microglial activation and associated neurotoxicity induced by aggregated alpha-synuclein. J Neuroinflammation 4 (2007) 2
37. Shie F.S., Breyer R.M., and Montine T.J. Microglia lacking E prostanoid receptor subtype 2 have enhanced Abeta phagocytosis yet lack Abeta-activated neurotoxicity. Am J Pathol 166 (2005) 1163-1172
38. 2 levels in patients with probable AD. Neurology 53 (1999) 1495-1498
39. 2 in plasma of schizophrenics and healthy controls by gas chromatography-negative-ion chemical ionization mass spectrometry and radioimmunoassay. J Chromatogr 420 (1987) 373-378
40. 2 levels in schizophrenia. J Neural Transm 77 (1989) 39-46
41. Hashimoto M., Hossain S., Shimada T., Sugioka K., Yamasaki H., Fujii Y., et al. Docosahexaenoic acid provides protection from impairment of learning ability in Alzheimer's disease model rats. J Neurochem 81 (2002) 1084-1091
42. Hashimoto M., Tanabe Y., Fujii Y., Kikuta T., Shibata H., and Shido O. Chronic administration of docosahexaenoic acid ameliorates the impairment of spatial cognition learning ability in amyloid beta-infused rats. J Nutr 135 (2005) 549-555
43. Martin D.S., Lonergan P.E., Boland B., Fogarty M.P., Brady M., Horrobin D.F., et al. Apoptotic changes in the aged brain are triggered by interleukin-1beta-induced activation of p38 and reversed by treatment with eicosapentaenoic acid. J Biol Chem 277 (2002) 34239-34246
44. Cansev M., and Wurtman R.J. Chronic administration of docosahexaenoic acid or eicosapentaenoic acid, but not arachidonic acid, alone or in combination with uridine, increases brain phosphatide and synaptic protein levels in gerbils. Neuroscience 148 (2007) 421-431
45. Calon F., Lim G.P., Morihara T., Yang F., Ubeda O., Salem Jr. N., et al. Dietary n-3 polyunsaturated fatty acid depletion activates caspases and decreases NMDA receptors in the brain of a transgenic mouse model of Alzheimer's disease. Eur J Neurosci 22 (2005) 617-626
46. Akbar M., Calderon F., Wen Z., and Kim H.Y. Docosahexaenoic acid: a positive modulator of Akt signaling in neuronal survival. Proc Natl Acad Sci U S A 102 (2005) 10858-10863
47. Kim H.Y., Akbar M., Lau A., and Edsall L. Inhibition of neuronal apoptosis by docosahexaenoic acid (22:6n-3). Role of phosphatidylserine in antiapoptotic effect. J Biol Chem 275 (2000) 35215-35223
48. Maher F.O., Martin D.S., and Lynch M.A. Increased IL-1beta in cortex of aged rats is accompanied by downregulation of ERK and PI-3 kinase. Neurobiol Aging 25 (2004) 795-806