메뉴 건너뛰기




Volumn 20, Issue 1, 2009, Pages 1-10

Experimental models and mechanisms underlying the protective effects of n-3 polyunsaturated fatty acids in Alzheimer's disease

Author keywords

Alzheimer's Disease; DHA; Fish oil; Mouse models; n 3 PUFA

Indexed keywords

AMYLOID PRECURSOR PROTEIN; APOLIPOPROTEIN E; ARACHIDONIC ACID; DOCOSAHEXAENOIC ACID; ICOSAPENTAENOIC ACID; ICOSAPENTAENOIC ACID ETHYL ESTER; OMEGA 3 FATTY ACID;

EID: 57049137646     PISSN: 09552863     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jnutbio.2008.05.016     Document Type: Review
Times cited : (98)

References (75)
  • 1
    • 0034641193 scopus 로고    scopus 로고
    • The incidence of dementia in Canada
    • The Canadian Study of Health and Aging Working Group
    • The Canadian Study of Health and Aging Working Group. The incidence of dementia in Canada. Neurology 55 (2000) 66-73
    • (2000) Neurology , vol.55 , pp. 66-73
  • 2
    • 57049182164 scopus 로고    scopus 로고
    • Alzheimer's Association Alzheimer's disease facts and figures 2007.
    • Alzheimer's Association Alzheimer's disease facts and figures 2007.
  • 3
    • 0042023711 scopus 로고    scopus 로고
    • Alzheimer disease in the US population: prevalence estimates using the 2000 census
    • Hebert L.E., Scherr P.A., Bienias J.L., Bennett D.A., and Evans D.A. Alzheimer disease in the US population: prevalence estimates using the 2000 census. Arch Neurol 60 (2003) 1119-1122
    • (2003) Arch Neurol , vol.60 , pp. 1119-1122
    • Hebert, L.E.1    Scherr, P.A.2    Bienias, J.L.3    Bennett, D.A.4    Evans, D.A.5
  • 4
    • 3943092621 scopus 로고    scopus 로고
    • Pathways towards and away from Alzheimer's disease
    • Mattson M.P. Pathways towards and away from Alzheimer's disease. Nature 430 (2004) 631-639
    • (2004) Nature , vol.430 , pp. 631-639
    • Mattson, M.P.1
  • 5
    • 18844378852 scopus 로고    scopus 로고
    • Presenilin function and gamma-secretase activity
    • Brunkan A.L., and Goate A.M. Presenilin function and gamma-secretase activity. J Neurochem 93 (2005) 769-792
    • (2005) J Neurochem , vol.93 , pp. 769-792
    • Brunkan, A.L.1    Goate, A.M.2
  • 6
    • 25144512007 scopus 로고    scopus 로고
    • Diet and Alzheimer's disease: what the evidence shows
    • Morris M.C. Diet and Alzheimer's disease: what the evidence shows. Med Gen Med 6 (2004) 48
    • (2004) Med Gen Med , vol.6 , pp. 48
    • Morris, M.C.1
  • 7
    • 28444434796 scopus 로고    scopus 로고
    • Docosahexaenoic acid, fatty acid-interacting proteins, and neuronal function: breastmilk and fish are good for you
    • Marszalek J.R., and Lodish H.F. Docosahexaenoic acid, fatty acid-interacting proteins, and neuronal function: breastmilk and fish are good for you. Annu Rev Cell Dev Biol 21 (2005) 633-657
    • (2005) Annu Rev Cell Dev Biol , vol.21 , pp. 633-657
    • Marszalek, J.R.1    Lodish, H.F.2
  • 8
    • 0038292118 scopus 로고    scopus 로고
    • Essential fatty acids and the brain
    • Haag M. Essential fatty acids and the brain. Can J Psychiatry 48 (2003) 195-203
    • (2003) Can J Psychiatry , vol.48 , pp. 195-203
    • Haag, M.1
  • 9
    • 0034884757 scopus 로고    scopus 로고
    • Physiological compartmental analysis of alpha-linolenic acid metabolism in adult humans
    • Pawlosky R.J., Hibbeln J.R., Novotny J.A., and Salem Jr. N. Physiological compartmental analysis of alpha-linolenic acid metabolism in adult humans. J Lipid Res 42 (2001) 1257-1265
    • (2001) J Lipid Res , vol.42 , pp. 1257-1265
    • Pawlosky, R.J.1    Hibbeln, J.R.2    Novotny, J.A.3    Salem Jr., N.4
  • 10
    • 33750139770 scopus 로고    scopus 로고
    • Innovative dietary sources of n-3 fatty acids
    • Whelan J., and Rust C. Innovative dietary sources of n-3 fatty acids. Annu Rev Nutr 26 (2006) 75-103
    • (2006) Annu Rev Nutr , vol.26 , pp. 75-103
    • Whelan, J.1    Rust, C.2
  • 12
    • 0035167408 scopus 로고    scopus 로고
    • Mechanisms of action of docosahexaenoic acid in the nervous system
    • Salem Jr. N., Litman B., Kim H.Y., and Gawrisch K. Mechanisms of action of docosahexaenoic acid in the nervous system. Lipids 36 (2001) 945-959
    • (2001) Lipids , vol.36 , pp. 945-959
    • Salem Jr., N.1    Litman, B.2    Kim, H.Y.3    Gawrisch, K.4
  • 13
    • 34247108513 scopus 로고    scopus 로고
    • Dietary (n-3) fatty acids and brain development
    • Innis S.M. Dietary (n-3) fatty acids and brain development. J Nutr 137 (2007) 855-859
    • (2007) J Nutr , vol.137 , pp. 855-859
    • Innis, S.M.1
  • 14
    • 0000657628 scopus 로고    scopus 로고
    • Effect of the long-term feeding of dietary lipids on the learning ability, fatty acid composition of brain stem phospholipids and synaptic membrane fluidity in adult mice: a comparison of sardine oil diet with palm oil diet
    • Suzuki H., Park S.J., Tamura M., and Ando S. Effect of the long-term feeding of dietary lipids on the learning ability, fatty acid composition of brain stem phospholipids and synaptic membrane fluidity in adult mice: a comparison of sardine oil diet with palm oil diet. Mech Ageing Dev 101 (1998) 119-128
    • (1998) Mech Ageing Dev , vol.101 , pp. 119-128
    • Suzuki, H.1    Park, S.J.2    Tamura, M.3    Ando, S.4
  • 15
    • 0034282175 scopus 로고    scopus 로고
    • Age-related changes in ethanolamine glycerophospholipid fatty acid levels in rat frontal cortex and hippocampus
    • Favreliere S., Stadelmann-Ingrand S., Huguet F., De J.D., Piriou A., Tallineau C., et al. Age-related changes in ethanolamine glycerophospholipid fatty acid levels in rat frontal cortex and hippocampus. Neurobiol Aging 21 (2000) 653-660
    • (2000) Neurobiol Aging , vol.21 , pp. 653-660
    • Favreliere, S.1    Stadelmann-Ingrand, S.2    Huguet, F.3    De, J.D.4    Piriou, A.5    Tallineau, C.6
  • 16
    • 38049098106 scopus 로고    scopus 로고
    • The low density lipoprotein receptor is not necessary for maintaining mouse brain polyunsaturated fatty acid concentrations
    • Chen C.T., Ma D.W., Kim J.H., Mount H.T., and Bazinet R.P. The low density lipoprotein receptor is not necessary for maintaining mouse brain polyunsaturated fatty acid concentrations. J Lipid Res 49 (2008) 147-152
    • (2008) J Lipid Res , vol.49 , pp. 147-152
    • Chen, C.T.1    Ma, D.W.2    Kim, J.H.3    Mount, H.T.4    Bazinet, R.P.5
  • 17
    • 34248204099 scopus 로고    scopus 로고
    • Docosahexaenoic acid synthesis from alpha-linolenic acid by rat brain is unaffected by dietary n-3 PUFA deprivation
    • Igarashi M., Demar Jr. J.C., Ma K., Chang L., Bell J.M., and Rapoport S.I. Docosahexaenoic acid synthesis from alpha-linolenic acid by rat brain is unaffected by dietary n-3 PUFA deprivation. J Lipid Res 48 (2007) 1150-1158
    • (2007) J Lipid Res , vol.48 , pp. 1150-1158
    • Igarashi, M.1    Demar Jr., J.C.2    Ma, K.3    Chang, L.4    Bell, J.M.5    Rapoport, S.I.6
  • 18
    • 0031692458 scopus 로고    scopus 로고
    • Astrocytes are mainly responsible for the polyunsaturated fatty acid enrichment in blood-brain barrier endothelial cells in vitro
    • Bernoud N., Fenart L., Benistant C., Pageaux J.F., Dehouck M.P., Moliere P., et al. Astrocytes are mainly responsible for the polyunsaturated fatty acid enrichment in blood-brain barrier endothelial cells in vitro. J Lipid Res 39 (1998) 1816-1824
    • (1998) J Lipid Res , vol.39 , pp. 1816-1824
    • Bernoud, N.1    Fenart, L.2    Benistant, C.3    Pageaux, J.F.4    Dehouck, M.P.5    Moliere, P.6
  • 21
    • 38649085664 scopus 로고    scopus 로고
    • Effect of Fatty acids isolated from edible oils like mustard, linseed or coconut on astrocytes maturation
    • Joardar A., and Das S. Effect of Fatty acids isolated from edible oils like mustard, linseed or coconut on astrocytes maturation. Cell Mol Neurobiol 27 (2007) 973-983
    • (2007) Cell Mol Neurobiol , vol.27 , pp. 973-983
    • Joardar, A.1    Das, S.2
  • 22
    • 33644758176 scopus 로고    scopus 로고
    • Docosahexaenoic acid facilitates cell maturation and beta-adrenergic transmission in astrocytes
    • Joardar A., Sen A.K., and Das S. Docosahexaenoic acid facilitates cell maturation and beta-adrenergic transmission in astrocytes. J Lipid Res 47 (2006) 571-581
    • (2006) J Lipid Res , vol.47 , pp. 571-581
    • Joardar, A.1    Sen, A.K.2    Das, S.3
  • 23
    • 34247157293 scopus 로고    scopus 로고
    • Eicosapentaenoic acid confers neuroprotection in the amyloid-beta challenged aged hippocampus
    • Lynch A.M., Loane D.J., Minogue A.M., Clarke R.M., Kilroy D., Nally R.E., et al. Eicosapentaenoic acid confers neuroprotection in the amyloid-beta challenged aged hippocampus. Neurobiol Aging 28 (2007) 845-855
    • (2007) Neurobiol Aging , vol.28 , pp. 845-855
    • Lynch, A.M.1    Loane, D.J.2    Minogue, A.M.3    Clarke, R.M.4    Kilroy, D.5    Nally, R.E.6
  • 24
    • 40549119867 scopus 로고    scopus 로고
    • Eicosapentaenoic acid stimulates the expression of myelin proteins in rat brain
    • Salvati S., Natali F., Attorri L., Di B.R., Leonardi F., Di B.A., et al. Eicosapentaenoic acid stimulates the expression of myelin proteins in rat brain. J Neurosci Res 86 (2008) 776-784
    • (2008) J Neurosci Res , vol.86 , pp. 776-784
    • Salvati, S.1    Natali, F.2    Attorri, L.3    Di, B.R.4    Leonardi, F.5    Di, B.A.6
  • 26
    • 34147107925 scopus 로고    scopus 로고
    • Plasma n-3 fatty acids and the risk of cognitive decline in older adults: the Atherosclerosis Risk in Communities Study
    • Beydoun M.A., Kaufman J.S., Satia J.A., Rosamond W., and Folsom A.R. Plasma n-3 fatty acids and the risk of cognitive decline in older adults: the Atherosclerosis Risk in Communities Study. Am J Clin Nutr 85 (2007) 1103-1111
    • (2007) Am J Clin Nutr , vol.85 , pp. 1103-1111
    • Beydoun, M.A.1    Kaufman, J.S.2    Satia, J.A.3    Rosamond, W.4    Folsom, A.R.5
  • 28
    • 27644537715 scopus 로고    scopus 로고
    • Benefits of fatty fish on dementia risk are stronger for those without APOE epsilon4
    • Huang T.L., Zandi P.P., Tucker K.L., Fitzpatrick A.L., Kuller L.H., Fried L.P., et al. Benefits of fatty fish on dementia risk are stronger for those without APOE epsilon4. Neurology 65 (2005) 1409-1414
    • (2005) Neurology , vol.65 , pp. 1409-1414
    • Huang, T.L.1    Zandi, P.P.2    Tucker, K.L.3    Fitzpatrick, A.L.4    Kuller, L.H.5    Fried, L.P.6
  • 32
    • 33750982113 scopus 로고    scopus 로고
    • Plasma phosphatidylcholine docosahexaenoic acid content and risk of dementia and Alzheimer disease: the Framingham Heart Study
    • Schaefer E.J., Bongard V., Beiser A.S., Lamon-Fava S., Robins S.J., Au R., et al. Plasma phosphatidylcholine docosahexaenoic acid content and risk of dementia and Alzheimer disease: the Framingham Heart Study. Arch Neurol 63 (2006) 1545-1550
    • (2006) Arch Neurol , vol.63 , pp. 1545-1550
    • Schaefer, E.J.1    Bongard, V.2    Beiser, A.S.3    Lamon-Fava, S.4    Robins, S.J.5    Au, R.6
  • 33
    • 34147100004 scopus 로고    scopus 로고
    • Fish consumption, n-3 fatty acids, and subsequent 5-y cognitive decline in elderly men: the Zutphen Elderly Study
    • van Gelder B.M., Tijhuis M., Kalmijn S., and Kromhout D. Fish consumption, n-3 fatty acids, and subsequent 5-y cognitive decline in elderly men: the Zutphen Elderly Study. Am J Clin Nutr 85 (2007) 1142-1147
    • (2007) Am J Clin Nutr , vol.85 , pp. 1142-1147
    • van Gelder, B.M.1    Tijhuis, M.2    Kalmijn, S.3    Kromhout, D.4
  • 34
    • 0034500422 scopus 로고    scopus 로고
    • Fatty acid analysis of blood plasma of patients with Alzheimer's disease, other types of dementia, and cognitive impairment
    • Conquer J.A., Tierney M.C., Zecevic J., Bettger W.J., and Fisher R.H. Fatty acid analysis of blood plasma of patients with Alzheimer's disease, other types of dementia, and cognitive impairment. Lipids 35 (2000) 1305-1312
    • (2000) Lipids , vol.35 , pp. 1305-1312
    • Conquer, J.A.1    Tierney, M.C.2    Zecevic, J.3    Bettger, W.J.4    Fisher, R.H.5
  • 35
    • 0036449651 scopus 로고    scopus 로고
    • Similarities and differences between Alzheimer's disease and vascular dementia from the viewpoint of nutrition
    • Otsuka M., Yamaguchi K., and Ueki A. Similarities and differences between Alzheimer's disease and vascular dementia from the viewpoint of nutrition. Ann N Y Acad Sci 977 (2002) 155-161
    • (2002) Ann N Y Acad Sci , vol.977 , pp. 155-161
    • Otsuka, M.1    Yamaguchi, K.2    Ueki, A.3
  • 36
    • 0037650162 scopus 로고    scopus 로고
    • Low serum cholesteryl ester-docosahexaenoic acid levels in Alzheimer's disease: a case-control study
    • Tully A.M., Roche H.M., Doyle R., Fallon C., Bruce I., Lawlor B., et al. Low serum cholesteryl ester-docosahexaenoic acid levels in Alzheimer's disease: a case-control study. Br J Nutr 89 (2003) 483-489
    • (2003) Br J Nutr , vol.89 , pp. 483-489
    • Tully, A.M.1    Roche, H.M.2    Doyle, R.3    Fallon, C.4    Bruce, I.5    Lawlor, B.6
  • 37
    • 33749633921 scopus 로고    scopus 로고
    • Omega-3 fatty acid treatment in 174 patients with mild to moderate Alzheimer disease: OmegAD study: a randomized double-blind trial
    • Freund-Levi Y., Eriksdotter-Jonhagen M., Cederholm T., Basun H., Faxen-Irving G., Garlind A., et al. Omega-3 fatty acid treatment in 174 patients with mild to moderate Alzheimer disease: OmegAD study: a randomized double-blind trial. Arch Neurol 63 (2006) 1402-1408
    • (2006) Arch Neurol , vol.63 , pp. 1402-1408
    • Freund-Levi, Y.1    Eriksdotter-Jonhagen, M.2    Cederholm, T.3    Basun, H.4    Faxen-Irving, G.5    Garlind, A.6
  • 39
    • 33748534825 scopus 로고    scopus 로고
    • Dietary supplementation of arachidonic and docosahexaenoic acids improves cognitive dysfunction
    • Kotani S., Sakaguchi E., Warashina S., Matsukawa N., Ishikura Y., Kiso Y., et al. Dietary supplementation of arachidonic and docosahexaenoic acids improves cognitive dysfunction. Neurosci Res 56 (2006) 159-164
    • (2006) Neurosci Res , vol.56 , pp. 159-164
    • Kotani, S.1    Sakaguchi, E.2    Warashina, S.3    Matsukawa, N.4    Ishikura, Y.5    Kiso, Y.6
  • 40
    • 26444598506 scopus 로고    scopus 로고
    • A role for docosahexaenoic acid-derived neuroprotectin D1 in neural cell survival and Alzheimer disease
    • Lukiw W.J., Cui J.G., Marcheselli V.L., Bodker M., Botkjaer A., Gotlinger K., et al. A role for docosahexaenoic acid-derived neuroprotectin D1 in neural cell survival and Alzheimer disease. J Clin Invest 115 (2005) 2774-2783
    • (2005) J Clin Invest , vol.115 , pp. 2774-2783
    • Lukiw, W.J.1    Cui, J.G.2    Marcheselli, V.L.3    Bodker, M.4    Botkjaer, A.5    Gotlinger, K.6
  • 41
    • 0032571154 scopus 로고    scopus 로고
    • Abnormal content of n-6 and n-3 long-chain unsaturated fatty acids in the phosphoglycerides and cholesterol esters of parahippocampal cortex from Alzheimer's disease patients and its relationship to acetyl CoA content
    • Corrigan F.M., Horrobin D.F., Skinner E.R., Besson J.A., and Cooper M.B. Abnormal content of n-6 and n-3 long-chain unsaturated fatty acids in the phosphoglycerides and cholesterol esters of parahippocampal cortex from Alzheimer's disease patients and its relationship to acetyl CoA content. Int J Biochem Cell Biol 30 (1998) 197-207
    • (1998) Int J Biochem Cell Biol , vol.30 , pp. 197-207
    • Corrigan, F.M.1    Horrobin, D.F.2    Skinner, E.R.3    Besson, J.A.4    Cooper, M.B.5
  • 43
    • 0025913434 scopus 로고
    • Fatty acid composition of brain phospholipids in aging and in Alzheimer's disease
    • Soderberg M., Edlund C., Kristensson K., and Dallner G. Fatty acid composition of brain phospholipids in aging and in Alzheimer's disease. Lipids 26 (1991) 421-425
    • (1991) Lipids , vol.26 , pp. 421-425
    • Soderberg, M.1    Edlund, C.2    Kristensson, K.3    Dallner, G.4
  • 44
    • 33747180133 scopus 로고    scopus 로고
    • Impact of different saturated fatty acid, polyunsaturated fatty acid and cholesterol containing diets on beta-amyloid accumulation in APP/PS1 transgenic mice
    • Oksman M., Iivonen H., Hogyes E., Amtul Z., Penke B., Leenders I., et al. Impact of different saturated fatty acid, polyunsaturated fatty acid and cholesterol containing diets on beta-amyloid accumulation in APP/PS1 transgenic mice. Neurobiol Dis 23 (2006) 563-572
    • (2006) Neurobiol Dis , vol.23 , pp. 563-572
    • Oksman, M.1    Iivonen, H.2    Hogyes, E.3    Amtul, Z.4    Penke, B.5    Leenders, I.6
  • 45
    • 23344439553 scopus 로고    scopus 로고
    • Docosahexaenoic acid: a positive modulator of Akt signaling in neuronal survival
    • Akbar M., Calderon F., Wen Z., and Kim H.Y. Docosahexaenoic acid: a positive modulator of Akt signaling in neuronal survival. Proc Natl Acad Sci U S A 102 (2005) 10858-10863
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 10858-10863
    • Akbar, M.1    Calderon, F.2    Wen, Z.3    Kim, H.Y.4
  • 46
    • 33644875009 scopus 로고    scopus 로고
    • Docosahexaenoic acid prevents neuronal apoptosis induced by soluble amyloid-beta oligomers
    • Florent S., Malaplate-Armand C., Youssef I., Kriem B., Koziel V., Escanye M.C., et al. Docosahexaenoic acid prevents neuronal apoptosis induced by soluble amyloid-beta oligomers. J Neurochem 96 (2006) 385-395
    • (2006) J Neurochem , vol.96 , pp. 385-395
    • Florent, S.1    Malaplate-Armand, C.2    Youssef, I.3    Kriem, B.4    Koziel, V.5    Escanye, M.C.6
  • 47
    • 16244416174 scopus 로고    scopus 로고
    • A diet enriched with the omega-3 fatty acid docosahexaenoic acid reduces amyloid burden in an aged Alzheimer mouse model
    • Lim G.P., Calon F., Morihara T., Yang F., Teter B., Ubeda O., et al. A diet enriched with the omega-3 fatty acid docosahexaenoic acid reduces amyloid burden in an aged Alzheimer mouse model. J Neurosci 25 (2005) 3032-3040
    • (2005) J Neurosci , vol.25 , pp. 3032-3040
    • Lim, G.P.1    Calon, F.2    Morihara, T.3    Yang, F.4    Teter, B.5    Ubeda, O.6
  • 48
    • 4444223956 scopus 로고    scopus 로고
    • Docosahexaenoic acid protects from dendritic pathology in an Alzheimer's disease mouse model
    • Calon F., Lim G.P., Yang F., Morihara T., Teter B., Ubeda O., et al. Docosahexaenoic acid protects from dendritic pathology in an Alzheimer's disease mouse model. Neuron 43 (2004) 633-645
    • (2004) Neuron , vol.43 , pp. 633-645
    • Calon, F.1    Lim, G.P.2    Yang, F.3    Morihara, T.4    Teter, B.5    Ubeda, O.6
  • 49
    • 31044440027 scopus 로고    scopus 로고
    • Docosahexaenoic acid-induced amelioration on impairment of memory learning in amyloid beta-infused rats relates to the decreases of amyloid beta and cholesterol levels in detergent-insoluble membrane fractions
    • Hashimoto M., Hossain S., Agdul H., and Shido O. Docosahexaenoic acid-induced amelioration on impairment of memory learning in amyloid beta-infused rats relates to the decreases of amyloid beta and cholesterol levels in detergent-insoluble membrane fractions. Biochim Biophys Acta 1738 (2005) 91-98
    • (2005) Biochim Biophys Acta , vol.1738 , pp. 91-98
    • Hashimoto, M.1    Hossain, S.2    Agdul, H.3    Shido, O.4
  • 50
    • 14944376646 scopus 로고    scopus 로고
    • Chronic administration of docosahexaenoic acid ameliorates the impairment of spatial cognition learning ability in amyloid beta-infused rats
    • Hashimoto M., Tanabe Y., Fujii Y., Kikuta T., Shibata H., and Shido O. Chronic administration of docosahexaenoic acid ameliorates the impairment of spatial cognition learning ability in amyloid beta-infused rats. J Nutr 135 (2005) 549-555
    • (2005) J Nutr , vol.135 , pp. 549-555
    • Hashimoto, M.1    Tanabe, Y.2    Fujii, Y.3    Kikuta, T.4    Shibata, H.5    Shido, O.6
  • 51
    • 0036319034 scopus 로고    scopus 로고
    • Docosahexaenoic acid provides protection from impairment of learning ability in Alzheimer's disease model rats
    • Hashimoto M., Hossain S., Shimada T., Sugioka K., Yamasaki H., Fujii Y., et al. Docosahexaenoic acid provides protection from impairment of learning ability in Alzheimer's disease model rats. J Neurochem 81 (2002) 1084-1091
    • (2002) J Neurochem , vol.81 , pp. 1084-1091
    • Hashimoto, M.1    Hossain, S.2    Shimada, T.3    Sugioka, K.4    Yamasaki, H.5    Fujii, Y.6
  • 52
    • 33748907870 scopus 로고    scopus 로고
    • Docosahexaenoic acid-induced protective effect against impaired learning in amyloid beta-infused rats is associated with increased synaptosomal membrane fluidity
    • Hashimoto M., Hossain S., Shimada T., and Shido O. Docosahexaenoic acid-induced protective effect against impaired learning in amyloid beta-infused rats is associated with increased synaptosomal membrane fluidity. Clin Exp Pharmacol Physiol 33 (2006) 934-939
    • (2006) Clin Exp Pharmacol Physiol , vol.33 , pp. 934-939
    • Hashimoto, M.1    Hossain, S.2    Shimada, T.3    Shido, O.4
  • 53
    • 34247380762 scopus 로고    scopus 로고
    • Dietary docosahexaenoic acid and docosapentaenoic acid ameliorate amyloid-beta and tau pathology via a mechanism involving presenilin 1 levels
    • Green K.N., Martinez-Coria H., Khashwji H., Hall E.B., Yurko-Mauro K.A., Ellis L., et al. Dietary docosahexaenoic acid and docosapentaenoic acid ameliorate amyloid-beta and tau pathology via a mechanism involving presenilin 1 levels. J Neurosci 27 (2007) 4385-4395
    • (2007) J Neurosci , vol.27 , pp. 4385-4395
    • Green, K.N.1    Martinez-Coria, H.2    Khashwji, H.3    Hall, E.B.4    Yurko-Mauro, K.A.5    Ellis, L.6
  • 54
    • 0141596079 scopus 로고    scopus 로고
    • Transgenic mouse models of Alzheimer's disease: phenotype and application
    • Higgins G.A., and Jacobsen H. Transgenic mouse models of Alzheimer's disease: phenotype and application. Behav Pharmacol 14 (2003) 419-438
    • (2003) Behav Pharmacol , vol.14 , pp. 419-438
    • Higgins, G.A.1    Jacobsen, H.2
  • 55
    • 0042697305 scopus 로고    scopus 로고
    • Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction
    • Oddo S., Caccamo A., Shepherd J.D., Murphy M.P., Golde T.E., Kayed R., et al. Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction. Neuron 39 (2003) 409-421
    • (2003) Neuron , vol.39 , pp. 409-421
    • Oddo, S.1    Caccamo, A.2    Shepherd, J.D.3    Murphy, M.P.4    Golde, T.E.5    Kayed, R.6
  • 57
    • 0033755730 scopus 로고    scopus 로고
    • AHA Dietary Guidelines: revision 2000: a statement for healthcare professionals from the Nutrition Committee of the American Heart Association
    • Krauss R.M., Eckel R.H., Howard B., Appel L.J., Daniels S.R., Deckelbaum R.J., et al. AHA Dietary Guidelines: revision 2000: a statement for healthcare professionals from the Nutrition Committee of the American Heart Association. Stroke 31 (2000) 2751-2766
    • (2000) Stroke , vol.31 , pp. 2751-2766
    • Krauss, R.M.1    Eckel, R.H.2    Howard, B.3    Appel, L.J.4    Daniels, S.R.5    Deckelbaum, R.J.6
  • 58
    • 33746999977 scopus 로고    scopus 로고
    • Dietary intakes and food sources of fatty acids for Belgian women, focused on n-6 and n-3 polyunsaturated fatty acids
    • Sioen I.A., Pynaert I., Matthys C., De B.G., Van C.J., and De H.S. Dietary intakes and food sources of fatty acids for Belgian women, focused on n-6 and n-3 polyunsaturated fatty acids. Lipids 41 (2006) 415-422
    • (2006) Lipids , vol.41 , pp. 415-422
    • Sioen, I.A.1    Pynaert, I.2    Matthys, C.3    De, B.G.4    Van, C.J.5    De, H.S.6
  • 59
    • 0345669752 scopus 로고    scopus 로고
    • Alzheimer's disease: the cholesterol connection
    • Puglielli L., Tanzi R.E., and Kovacs D.M. Alzheimer's disease: the cholesterol connection. Nat Neurosci 6 (2003) 345-351
    • (2003) Nat Neurosci , vol.6 , pp. 345-351
    • Puglielli, L.1    Tanzi, R.E.2    Kovacs, D.M.3
  • 60
    • 34247330919 scopus 로고    scopus 로고
    • Modulation of inflammation in brain: a matter of fat
    • Farooqui, Horrocks, and Farooqui T. Modulation of inflammation in brain: a matter of fat. J Neurochem 101 (2007) 577-599
    • (2007) J Neurochem , vol.101 , pp. 577-599
    • Farooqui1    Horrocks2    Farooqui, T.3
  • 61
    • 0029657725 scopus 로고    scopus 로고
    • Cytosolic phospholipase A2 (cPLA2) immunoreactivity is elevated in Alzheimer's disease brain
    • Stephenson D.T., Lemere C.A., Selkoe D.J., and Clemens J.A. Cytosolic phospholipase A2 (cPLA2) immunoreactivity is elevated in Alzheimer's disease brain. Neurobiol Dis 3 (1996) 51-63
    • (1996) Neurobiol Dis , vol.3 , pp. 51-63
    • Stephenson, D.T.1    Lemere, C.A.2    Selkoe, D.J.3    Clemens, J.A.4
  • 62
    • 0033526660 scopus 로고    scopus 로고
    • Distribution of cyclooxygenase-1 and cyclooxygenase-2 mRNAs and proteins in human brain and peripheral organs
    • Yasojima K., Schwab C., McGeer E.G., and McGeer P.L. Distribution of cyclooxygenase-1 and cyclooxygenase-2 mRNAs and proteins in human brain and peripheral organs. Brain Res 830 (1999) 226-236
    • (1999) Brain Res , vol.830 , pp. 226-236
    • Yasojima, K.1    Schwab, C.2    McGeer, E.G.3    McGeer, P.L.4
  • 63
    • 34250002065 scopus 로고    scopus 로고
    • The onset of brain injury and neurodegeneration triggers the synthesis of docosanoid neuroprotective signaling
    • Bazan N.G. The onset of brain injury and neurodegeneration triggers the synthesis of docosanoid neuroprotective signaling. Cell Mol Neurobiol 26 (2006) 901-913
    • (2006) Cell Mol Neurobiol , vol.26 , pp. 901-913
    • Bazan, N.G.1
  • 64
    • 33846540379 scopus 로고    scopus 로고
    • Dietary n-3 PUFA deprivation alters expression of enzymes of the arachidonic and docosahexaenoic acid cascades in rat frontal cortex
    • Rao J.S., Ertley R.N., Demar Jr. J.C., Rapoport S.I., Bazinet R.P., and Lee H.J. Dietary n-3 PUFA deprivation alters expression of enzymes of the arachidonic and docosahexaenoic acid cascades in rat frontal cortex. Mol Psychiatry 12 (2007) 151-157
    • (2007) Mol Psychiatry , vol.12 , pp. 151-157
    • Rao, J.S.1    Ertley, R.N.2    Demar Jr., J.C.3    Rapoport, S.I.4    Bazinet, R.P.5    Lee, H.J.6
  • 65
    • 33845775752 scopus 로고    scopus 로고
    • n-3 polyunsaturated fatty acid deprivation in rats decreases frontal cortex BDNF via a p38 MAPK-dependent mechanism
    • Rao J.S., Ertley R.N., Lee H.J., DeMar Jr. J.C., Arnold J.T., Rapoport S.I., et al. n-3 polyunsaturated fatty acid deprivation in rats decreases frontal cortex BDNF via a p38 MAPK-dependent mechanism. Mol Psychiatry 12 (2007) 36-46
    • (2007) Mol Psychiatry , vol.12 , pp. 36-46
    • Rao, J.S.1    Ertley, R.N.2    Lee, H.J.3    DeMar Jr., J.C.4    Arnold, J.T.5    Rapoport, S.I.6
  • 66
    • 33746085241 scopus 로고    scopus 로고
    • Rafts defined: a report on the Keystone Symposium on Lipid Rafts and Cell Function
    • Pike L.J. Rafts defined: a report on the Keystone Symposium on Lipid Rafts and Cell Function. J Lipid Res 47 (2006) 1597-1598
    • (2006) J Lipid Res , vol.47 , pp. 1597-1598
    • Pike, L.J.1
  • 67
    • 2142647335 scopus 로고    scopus 로고
    • The biology of caveolae: lessons from caveolin knockout mice and implications for human disease
    • Hnasko R., and Lisanti M.P. The biology of caveolae: lessons from caveolin knockout mice and implications for human disease. Mol Interv 3 (2003) 445-464
    • (2003) Mol Interv , vol.3 , pp. 445-464
    • Hnasko, R.1    Lisanti, M.P.2
  • 68
    • 0032562615 scopus 로고    scopus 로고
    • Caveolae, plasma membrane microdomains for alpha-secretase-mediated processing of the amyloid precursor protein
    • Ikezu T., Trapp B.D., Song K.S., Schlegel A., Lisanti M.P., and Okamoto T. Caveolae, plasma membrane microdomains for alpha-secretase-mediated processing of the amyloid precursor protein. J Biol Chem 273 (1998) 10485-10495
    • (1998) J Biol Chem , vol.273 , pp. 10485-10495
    • Ikezu, T.1    Trapp, B.D.2    Song, K.S.3    Schlegel, A.4    Lisanti, M.P.5    Okamoto, T.6
  • 69
    • 0141482022 scopus 로고    scopus 로고
    • Exclusively targeting beta-secretase to lipid rafts by GPI-anchor addition up-regulates beta-site processing of the amyloid precursor protein
    • Cordy J.M., Hussain I., Dingwall C., Hooper N.M., and Turner A.J. Exclusively targeting beta-secretase to lipid rafts by GPI-anchor addition up-regulates beta-site processing of the amyloid precursor protein. Proc Natl Acad Sci U S A 100 (2003) 11735-11740
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 11735-11740
    • Cordy, J.M.1    Hussain, I.2    Dingwall, C.3    Hooper, N.M.4    Turner, A.J.5
  • 70
    • 0037421206 scopus 로고    scopus 로고
    • Amyloidogenic processing of the Alzheimer beta-amyloid precursor protein depends on lipid rafts
    • Ehehalt R., Keller P., Haass C., Thiele C., and Simons K. Amyloidogenic processing of the Alzheimer beta-amyloid precursor protein depends on lipid rafts. J Cell Biol 160 (2003) 113-123
    • (2003) J Cell Biol , vol.160 , pp. 113-123
    • Ehehalt, R.1    Keller, P.2    Haass, C.3    Thiele, C.4    Simons, K.5
  • 71
    • 0035928732 scopus 로고    scopus 로고
    • Compartmentalization of beta-secretase (Asp2) into low-buoyant density, noncaveolar lipid rafts
    • Riddell D.R., Christie G., Hussain I., and Dingwall C. Compartmentalization of beta-secretase (Asp2) into low-buoyant density, noncaveolar lipid rafts. Curr Biol 11 (2001) 1288-1293
    • (2001) Curr Biol , vol.11 , pp. 1288-1293
    • Riddell, D.R.1    Christie, G.2    Hussain, I.3    Dingwall, C.4
  • 72
    • 6944240423 scopus 로고    scopus 로고
    • n-3 PUFA alter caveolae lipid composition and resident protein localization in mouse colon
    • Ma D.W., Seo J., Davidson, Callaway E.S., Fan Y.Y., Lupton J.R., et al. n-3 PUFA alter caveolae lipid composition and resident protein localization in mouse colon. FASEB J 18 (2004) 1040-1042
    • (2004) FASEB J , vol.18 , pp. 1040-1042
    • Ma, D.W.1    Seo, J.2    Davidson3    Callaway, E.S.4    Fan, Y.Y.5    Lupton, J.R.6
  • 73
    • 33947169954 scopus 로고    scopus 로고
    • (n-3) PUFA alter raft lipid composition and decrease epidermal growth factor receptor levels in lipid rafts of human breast cancer cells
    • Schley P.D., Brindley D.N., and Field C.J. (n-3) PUFA alter raft lipid composition and decrease epidermal growth factor receptor levels in lipid rafts of human breast cancer cells. J Nutr 137 (2007) 548-553
    • (2007) J Nutr , vol.137 , pp. 548-553
    • Schley, P.D.1    Brindley, D.N.2    Field, C.J.3
  • 74
    • 0142103875 scopus 로고    scopus 로고
    • Interaction of cholesterol with a docosahexaenoic acid-containing phosphatidylethanolamine: trigger for microdomain/raft formation?
    • Shaikh S.R., Cherezov V., Caffrey M., Stillwell W., and Wassall S.R. Interaction of cholesterol with a docosahexaenoic acid-containing phosphatidylethanolamine: trigger for microdomain/raft formation?. Biochemistry 42 (2003) 12028-12037
    • (2003) Biochemistry , vol.42 , pp. 12028-12037
    • Shaikh, S.R.1    Cherezov, V.2    Caffrey, M.3    Stillwell, W.4    Wassall, S.R.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.