High levels of retinal membrane docosahexaenoic acid increase susceptibility to stress-induced degeneration

Journal of Lipid Research

Volumn 50, Issue 5, 2009, Pages 807-819

  Tanito, Masaki ^a,b   Brush, Richard S ^a,b   Elliott, Michael H ^a,b   Wicker, Lea D ^a,b   Henry, Kimberly R ^a,b   Anderson, Robert E ^b,c  

^a Department of Ophthalmology ^*  (United States)

^b UNIVERSITY OF OKLAHOMA HEALTH SCIENCES CENTER   (United States)

^c UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

Author keywords

4 hydoroxynonenal(4 HNE); 4 hydroxyhexenal(4 HHE); Fat 1; N 3 fatty acid desaturase; Retinal light damage

Indexed keywords

DOCOSAHEXAENOIC ACID; EYE PROTEIN; LIPID; OMEGA 3 FATTY ACID; SAFFLOWER OIL; 4 HYDROXYNONENAL; 4-HYDROXY-2-NONENAL; ACYL COENZYME A DESATURASE; ALDEHYDE; CAENORHABDITIS ELEGANS PROTEIN; CYSTEINE PROTEINASE INHIBITOR; FAT 1 PROTEIN, C ELEGANS; FAT-1 PROTEIN, C ELEGANS;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOCHEMISTRY; CEREBELLUM; CONTROLLED STUDY; DIET; ELECTRORETINOGRAM; FATTY ACID OXIDATION; FEMALE; GENOTYPE; LIGHT EXPOSURE; LIPID ANALYSIS; LIPID COMPOSITION; LIPID PEROXIDATION; LIVER; MALE; MORPHOMETRICS; MOUSE; NONHUMAN; OXIDATIVE STRESS; PHOTORECEPTOR CELL; PHOTOTRANSDUCTION; PLASMA; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; RETINA DEGENERATION; TRANSGENE; WESTERN BLOTTING; WILD TYPE; ANIMAL; BAGG ALBINO MOUSE; C57BL MOUSE; CELL MEMBRANE; CHEMISTRY; CYTOLOGY; ELECTRORETINOGRAPHY; FAT INTAKE; GENETICS; HUMAN; LIGHT; METABOLISM; PHYSIOLOGICAL STRESS; PHYSIOLOGY; RETINA; RETINA ROD OUTER SEGMENT; TRANSGENIC MOUSE; ULTRASTRUCTURE;

ALDEHYDES; ANIMALS; CAENORHABDITIS ELEGANS PROTEINS; CELL MEMBRANE; CYSTEINE PROTEINASE INHIBITORS; DIETARY FATS; DOCOSAHEXAENOIC ACIDS; ELECTRORETINOGRAPHY; FATTY ACID DESATURASES; FEMALE; HUMANS; LIGHT; LIGHT SIGNAL TRANSDUCTION; LIPID PEROXIDATION; MALE; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, TRANSGENIC; RETINA; RETINAL DEGENERATION; ROD CELL OUTER SEGMENT; SAFFLOWER OIL; STRESS, PHYSIOLOGICAL; TRANSGENES;

EID: 67649739492     PISSN: 00222275     EISSN: 15397262     Source Type: Journal    
DOI: 10.1194/jlr.M800170-JLR200     Document Type: Article

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