Protection of cortical neurons from excitotoxicity by conjugated linoleic acid

Journal of Neurochemistry

Volumn 115, Issue 1, 2010, Pages 123-130

  Hunt, Waylon T ^a   Kamboj, Amit ^a   Anderson, Hope D ^b   Anderson, Christopher M ^a  

^a ST BONIFACE GENERAL HOSPITAL   (Canada)

^b UNIVERSITY OF MANITOBA   (Canada)

Author keywords

conjugated linoleic acid; delayed neuron death; excitotoxicity; glutamate; NMDA receptor; polyunsaturated fatty acid

Indexed keywords

CONJUGATED LINOLEIC ACID; GLUTAMIC ACID; PROTEIN BCL 2; 5,5',6,6'-TETRACHLORO-1,1',3,3'-TETRAETHYLBENZIMIDAZOLOCARBOCYANINE; AMINO ACID RECEPTOR STIMULATING AGENT; BENZIMIDAZOLE DERIVATIVE; CARBOCYANINE; FLUORESCENT DYE; NEUROPROTECTIVE AGENT;

ANIMAL CELL; ARTICLE; BRAIN CELL; CELL SURVIVAL; CONTROLLED STUDY; DIET SUPPLEMENTATION; EXCITOTOXICITY; MITOCHONDRIAL MEMBRANE POTENTIAL; MOUSE; NERVE CELL NECROSIS; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; STROKE; ANIMAL; BRAIN CORTEX; CELL CULTURE; CELL DEATH; CYTOLOGY; DRUG EFFECTS; MEMBRANE POTENTIAL; METABOLISM; MITOCHONDRIAL MEMBRANE; NERVE CELL; PHYSIOLOGY; TIME; TOXICITY; WESTERN BLOTTING;

ANIMALIA;

ANIMALS; BENZIMIDAZOLES; BLOTTING, WESTERN; CARBOCYANINES; CELL DEATH; CELLS, CULTURED; CEREBRAL CORTEX; EXCITATORY AMINO ACID AGONISTS; FLUORESCENT DYES; GLUTAMIC ACID; LINOLEIC ACIDS, CONJUGATED; MEMBRANE POTENTIALS; MICE; MITOCHONDRIAL MEMBRANES; NEURONS; NEUROPROTECTIVE AGENTS; PROTO-ONCOGENE PROTEINS C-BCL-2; TIME FACTORS;

EID: 77956576899     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2010.06908.x     Document Type: Article

References (39)

1. Alibin C. P., Kopilas M. A. Anderson H. D. (2008) Suppression of cardiac myocyte hypertrophy by conjugated linoleic acid: role of peroxisome proliferator-activated receptors alpha and gamma. J. Biol. Chem. 283, 10707 10715.
2. Bhattacharya A., Banu J., Rahman M., Causey J. Fernandes G. (2006) Biological effects of conjugated linoleic acids in health and disease. J. Nutr. Biochem. 17, 789 810.
3. Brenner D. Mak T. W. (2009) Mitochondrial cell death effectors. Curr. Opin. Cell Biol. 21, 871 877.
4. Choi D. W. (1988) Glutamate neurotoxicity and diseases of the nervous system. Neuron 1, 623 634.
5. Corona J. C., Tovar-y-Romo L. B. Tapia R. (2007) Glutamate excitotoxicity and therapeutic targets for amyotrophic lateral sclerosis. Expert Opin. Ther. Targets 11, 1415 1428.
6. Coyle J. T. Puttfarcken P. (1993) Oxidative stress, glutamate, and neurodegenerative disorders. Science 262, 689 695.
7. Doyle L., Jewell C., Mullen A., Nugent A. P., Roche H. M. Cashman K. D. (2005) Effect of dietary supplementation with conjugated linoleic acid on markers of calcium and bone metabolism in healthy adult men. Eur. J. Clin. Nutr. 59, 432 440.
8. Estrada Sanchez A. M., Mejia-Toiber J. Massieu L. (2008) Excitotoxic neuronal death and the pathogenesis of Huntington's disease. Arch. Med. Res. 39, 265 276.
9. Evans M., Geigerman C., Cook J., Curtis L., Kuebler B. McIntosh M. (2000) Conjugated linoleic acid suppresses triglyceride accumulation and induces apoptosis in 3T3-L1 preadipocytes. Lipids 35, 899 910.
10. Fa M., Diana A., Carta G., Cordeddu L., Melis M. P., Murru E., Sogos V. Banni S. (2005) Incorporation and metabolism of c9, t11 and t10, c12 conjugated linoleic acid (CLA) isomers in rat brain. Biochim. Biophys. Acta 1736, 61 66.
11. Fonnum F. (1984) Glutamate: a neurotransmitter in mammalian brain. J. Neurochem. 42, 1 11.
12. Fuenzalida K., Quintanilla R., Ramos P., Piderit D., Fuentealba R. A., Martinez G., Inestrosa N. C. Bronfman M. (2007) Peroxisome proliferator- activated receptor gamma up-regulates the Bcl-2 anti-apoptotic protein in neurons and induces mitochondrial stabilization and protection against oxidative stress and apoptosis. J. Biol. Chem. 282, 37006 37015.
13. Garcia-Bueno B., Caso J. R., Perez-Nievas B. G., Lorenzo P. Leza J. C. (2007) Effects of peroxisome proliferator-activated receptor gamma agonists on brain glucose and glutamate transporters after stress in rats. Neuropsychopharmacology 32, 1251 1260.
14. Herbel B. K., McGuire M. K., McGuire M. A. Shultz T. D. (1998) Safflower oil consumption does not increase plasma conjugated linoleic acid concentrations in humans. Am. J. Clin. Nutr. 67, 332 337.
15. Joo N. E. Park C. S. (2003) Inhibition of excitotoxicity in cultured rat cortical neurons by a mixture of conjugated linoleic acid isomers. Pharmacol. Res. 47, 305 310.
16. Kapadia R., Yi J. H. Vemuganti R. (2008) Mechanisms of anti-inflammatory and neuroprotective actions of PPAR-gamma agonists. Front. Biosci. 13, 1813 1826.
17. Lai K. L., Torres-Duarte A. P. Vanderhoek J. Y. (2005) 9-trans, 11-trans-CLA: antiproliferative and proapoptotic effects on bovine endothelial cells. Lipids 40, 1107 1116.
18. Lemberger T., Desvergne B. Wahli W. (1996) Peroxisome proliferator-activated receptors: a nuclear receptor signaling pathway in lipid physiology. Annu. Rev. Cell Dev. Biol. 12, 335 363.
19. Lopes P. A., Martins S. V. Pinho M. S. et al. (2008) Diet supplementation with the cis-9, trans-11 conjugated linoleic acid isomer affects the size of adipocytes in Wistar rats. Nutr. Res. 28, 480 486.
20. Martin J. C. Valeille K. (2002) Conjugated linoleic acids: all the same or to everyone its own function? Reprod. Nutr. Dev. 42, 525 536.
21. Miller A., Stanton C. Devery R. (2002) Cis 9, trans 11- and trans 10, cis 12-conjugated linoleic acid isomers induce apoptosis in cultured SW480 cells. Anticancer Res. 22, 3879 3887.
22. Moloney F., Toomey S., Noone E., Nugent A., Allan B., Loscher C. E. Roche H. M. (2007) Antidiabetic effects of cis-9, trans-11-conjugated linoleic acid may be mediated via anti-inflammatory effects in white adipose tissue. Diabetes 56, 574 582.
23. Montpied P., Weller M. Paul S. M. (1993) N-Methyl-D-aspartate receptor agonists decrease protooncogene bcl-2 mRNA expression in cultured cerebellar granule neurons. Biochim. Biophys. Res. Commun. 195, 623 629.
24. Moya-Camarena S. Y. Belury M. A. (1999) CLA and PPARgamma activation. J. Nutr. 129, 2106.
25. Moya-Camarena S. Y., Vanden Heuvel J. P., Blanchard S. G., Leesnitzer L. A. Belury M. A. (1999) Conjugated linoleic acid is a potent naturally occurring ligand and activator of PPARalpha. J. Lipid Res. 40, 1426 1433.
26. Nagao K., Inoue N., Wang Y. M., Hirata J., Shimada Y., Nagao T., Matsui T. Yanagita T. (2003) The 10trans, 12cis isomer of conjugated linoleic acid suppresses the development of hypertension in Otsuka Long-Evans Tokushima fatty rats. Biochem. Biophys. Res. Commun. 306, 134 138.
27. Nakanishi T., Koutoku T., Kawahara S., Murai A. Furuse M. (2003) Dietary conjugated linoleic acid reduces cerebral prostaglandin E2 in mice. Neurosci. Lett. 341, 135 138.
28. Navarro M. A., Badimon L., Rodriguez C., Arnal C., Noone E. J., Roche H. M., Osada J. Martinez-Gonzalez J. (2010) Trans-10, cis-12-CLA dysregulate lipid and glucose metabolism and induce hepatic NR4A receptors. Front. Biosci. (Elite Ed) 2, 87 97.
29. Nestel P., Fujii A. Allen T. (2006) The cis-9, trans-11 isomer of conjugated linoleic acid (CLA) lowers plasma triglyceride and raises HDL cholesterol concentrations but does not suppress aortic atherosclerosis in diabetic apoE-deficient mice. Atherosclerosis 189, 282 287.
30. Ochoa J. J., Farquarson A. J., Grant I., Moffat L. E., Heys S. D. Wahle K. W. (2004) Conjugated linoleic acids decrease prostate cancer cell proliferation: different molecular mechianisms of cis9, trans11 and trans10, cis12 isomers. Carcinogenesis 25, 1185 1191.
31. Palmquist D. L., Lock A. L., Shingfield K. J. Bauman D. E. (2005) Biosynthesis of conjugated linoleic Acid in ruminants and humans. Adv. Food Nutr. Res. 50, 179 217.
32. Riederer P. Hoyer S. (2006) From benefit to damage. Glutamate and advanced glycation end products in Alzheimer brain. J. Neural. Transm. 113, 1671 1677.
33. Roche H. M., Noone E., Sewter C., Mc Bennett S., Savage D., Gibney M. J., O'Rahilly S. Vidal-Puig A. J. (2002) Isomer-dependent metabolic effects of conjugated linoleic acid: insights from molecular markers sterol regulatory element-binding protein-1c and LXRalpha. Diabetes 51, 2037 2044.
34. Ryder J. W., Portocarrero C. P. Song X. M. et al. (2001) Isomer-specific antidiabetic properties of conjugated linoleic acid. Improved glucose tolerance, skeletal muscle insulin action, and UCP-2 gene expression. Diabetes 50, 1149 1157.
35. Sikorski A. M., Hebert N. Swain R. A. (2008) Conjugated Linoleic Acid (CLA) inhibits new vessel growth in the mammalian brain. Brain Res. 1213, 35 40.
36. Tholstrup T., Raff M., Straarup E. M., Lund P., Basu S. Bruun J. M. (2008) An oil mixture with trans-10, cis-12 conjugated linoleic acid increases markers of inflammation and in vivo lipid peroxidation compared with cis-9, trans-11 conjugated linoleic acid in postmenopausal women. J. Nutr. 138, 1445 1451.
37. Uryu S., Harada J., Hisamoto M. Oda T. (2002) Troglitazone inhibits both post-glutamate neurotoxicity and low-potassium-induced apoptosis in cerebellar granule neurons. Brain Res. 924, 229 236.
38. Zhao X., Ou Z., Grotta J. C., Waxham N. Aronowski J. (2006a) Peroxisome-proliferator-activated receptor-gamma (PPARgamma) activation protects neurons from NMDA excitotoxicity. Brain Res. 1073-1074, 460 469.
39. Zhao Y., Patzer A., Herdegen T., Gohlke P. Culman J. (2006b) Activation of cerebral peroxisome proliferator-activated receptors gamma promotes neuroprotection by attenuation of neuronal cyclooxygenase-2 overexpression after focal cerebral ischemia in rats. FASEB J. 20, 1162 1175.