Structural insight into the differential effects of omega-3 and omega-6 fatty acids on the production of Aβ peptides and amyloid plaques

Journal of Biological Chemistry

Volumn 286, Issue 8, 2011, Pages 6100-6107

  Amtul, Zareen ^a,b   Uhrig, Markus ^a   Rozmahel, Richard F ^b   Beyreuther, Konrad ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b UNIVERSITY OF WESTERN ONTARIO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ALZHEIMER DISEASE; AMYLOID PLAQUES; AMYLOID PRECURSOR PROTEINS; ANIMAL MODEL; ARACHIDONIC ACIDS; BENEFICIAL EFFECTS; DIFFERENTIAL EFFECT; DOWN-STREAM; ENZYME LINKED IMMUNOSORBENT ASSAY; FATTY ACYL CHAINS; HIGH-SENSITIVITY; IMMUNOBLOTTING; IN-VITRO; INDIANA; LONG CHAINS; OMEGA-3; OMEGA-6 FATTY ACIDS; PROTECTIVE EFFECTS; SECRETASES; STRUCTURAL INSIGHTS; STRUCTURAL TEMPLATES; STRUCTURE ACTIVITY RELATIONSHIPS; TRANSGENIC MICE;

GLYCOPROTEINS; PEPTIDES; SATURATED FATTY ACIDS;

MONOUNSATURATED FATTY ACIDS;

AMYLOID BETA PROTEIN[1-40]; AMYLOID BETA PROTEIN[1-42]; AMYLOID PRECURSOR PROTEIN; ARACHIDONIC ACID; ASPARAGINE; DOCOSAHEXAENOIC ACID; GAMMA SECRETASE; LEUCINE; LYSINE; METHIONINE; MONOUNSATURATED FATTY ACID; OMEGA 3 FATTY ACID; OMEGA 6 FATTY ACID; PHENYLALANINE; SATURATED FATTY ACID; VALINE;

ALZHEIMER DISEASE; AMYLOID PLAQUE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL STRAIN COS7; CONTROLLED STUDY; IN VITRO STUDY; LOW FAT DIET; MALE; MOUSE; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN SECRETION; PROTEIN SYNTHESIS;

ALZHEIMER DISEASE; AMYLOID; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; BRAIN; CERCOPITHECUS AETHIOPS; COS CELLS; DISEASE MODELS, ANIMAL; FATTY ACIDS, OMEGA-3; FATTY ACIDS, OMEGA-6; HUMANS; MICE; MICE, MUTANT STRAINS; PEPTIDES;

ANIMALIA; MUS MUSCULUS;

EID: 79953212240     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.183608     Document Type: Article

References (49)

1. Mattson, M. P. (2004) Nature 430, 631-639
2. Lambert, M. P., Barlow, A. K., Chromy, B. A., Edwards, C., Freed, R., Liosatos, M., Morgan, T. E., Rozovsky, I., Trommer, B., Viola, K. L., Wals, P., Zhang, C., Finch, C. E., Krafft, G. A., and Klein, W. L. (1998) Proc. Natl. Acad. Sci. U.S.A. 95, 6448-6453
3. McLean, C. A., Cherny, R. A., Fraser, F. W., Fuller, S. J., Smith, M. J., Beyreuther, K., Bush, A. I., and Masters, C. L. (1999) Ann. Neurol. 46, 860-866
4. St George-Hyslop, P. H. (2000) Sci. Am. 283, 76-83
5. Grimm, M. O., Grimm, H. S., Pätzold, A. J., Zinser, E. G., Halonen, R., Duering, M., Tschäpe, J. A., De Strooper, B., Müller, U., Shen, J., and Hartmann, T. (2005) Nat. Cell Biol. 7, 1118-1123
6. Simons, M., Keller, P., De Strooper, B., Beyreuther, K., Dotti, C. G., and Simons, K. (1998) Proc. Natl. Acad. Sci. U.S.A. 95, 6460-6464
7. Hashimoto, M., Tanabe, Y., Fujii, Y., Kikuta, T., Shibata, H., and Shido, O. (2005) J. Nutr. 135, 549-555
8. Hashimoto, M., Hossain, S., Agdul, H., and Shido, O. (2005) Biochim. Biophys. Acta 1738, 91-98
9. Lim, G. P., Calon, F., Morihara, T., Yang, F., Teter, B., Ubeda, O., Salem, N., Jr., Frautschy, S. A., and Cole, G. M. (2005) J. Neurosci. 25, 3032-3040
10. Patil, S., and Chan, C. (2005) Neurosci. Lett. 384, 288-293
11. Patil, S., Sheng, L., Masserang, A., and Chan, C. (2006) Neurosci. Lett. 406, 55-59
12. Chishti, M. A., Yang, D. S., Janus, C., Phinney, A. L., Horne, P., Pearson, J., Strome, R., Zuker, N., Loukides, J., French, J., Turner, S., Lozza, G., Grilli, M., Kunicki, S., Morissette, C., Paquette, J., Gervais, F., Bergeron, C., Fraser, P. E., Carlson, G. A., George-Hyslop, P. S., and Westaway, D. (2001) J. Biol. Chem. 276, 21562-21570
13. Lichtenthaler, S. F., Beher, D., Grimm, H. S., Wang, R., Shearman, M. S., Masters, C. L., and Beyreuther, K. (2002) Proc. Natl. Acad. Sci. U.S.A. 99, 1365-1370
14. Amtul, Z., Uhrig, M., Supino, R., and Beyreuther, K. (2010) Neurosci. Lett. 481, 73-77
15. Jensen, M., Hartmann, T., Engvall, B., Wang, R., Uljon, S. N., Sennvik, K., Näslund, J., Muehlhauser, F., Nordstedt, C., Beyreuther, K., and Lannfelt, L. (2000) Mol. Med. 6, 291-302
16. Ida, N., Hartmann, T., Pantel, J., Schröder, J., Zerfass, R., Förstl, H., Sandbrink, R., Masters, C. L., and Beyreuther, K. (1996) J. Biol. Chem. 271, 22908-22914
17. Tagawa, K., Maruyama, K., and Ishiura, S. (1992) Ann. N.Y. Acad. Sci. 674, 129-137
18. Hartmann, T., Bergsdorf, C., Sandbrink, R., Tienari, P. J., Multhaup, G., Ida, N., Bieger, S., Dyrks, T., Weidemann, A., Masters, C. L., and Beyreuther, K. (1996) J. Biol. Chem. 271, 13208-13214
19. Iizuka, T., Shoji, M., Kawarabayashi, T., Sato, M., Kobayashi, T., Tada, N., Kasai, K., Matsubara, E., Watanabe, M., Tomidokoro, Y., and Hirai, S. (1996) Biochem. Biophys. Res. Commun. 218, 238-242
20. Amtul, Z., Westaway, D., Cechetto, D., and Rozmahel, R. F. (2010) Oleic Acid Ameliorates Amyloidosis in Cellular and Mouse Models of Alzheimer's Disease (in press), 2010 Oct 5. doi:10.1111/j.1750-3639.2010.00449
21. Oksman, M., Iivonen, H., Hogyes, E., Amtul, Z., Penke, B., Leenders, I., Broersen, L., Lütjohann, D., Hartmann, T., and Tanila, H. (2006) Neurobiol. Dis. 23, 563-572
22. Carta, G., Angioni, E., Murru, E., Melis, M. P., Spada, S., and Banni, S. (2002) Prostaglandins Leukot. Essent. Fatty Acids 67, 187-191
23. Kulkarni, P. S., and Srinivasan, B. D. (1986) Prostaglandins 31, 1159-1164
24. Kulkarni, P. S., Kaufman, P. L., and Srinivasan, B. D. (1987) J. Ocul. Pharmacol. 3, 349-356
25. Oda, M., Ueno, T., Kasai, N., Takahashi, H., Yoshida, H., Sugawara, F., Sakaguchi, K., Hayashi, H., and Mizushina, Y. (2002) Biochem. J. 367, 329-334
26. Birch, E. E., Birch, D. G., Hoffman, D. R., and Uauy, R. (1992) Invest. Ophthalmol. Vis. Sci. 33, 3242-3253
27. Davis, P. J. (1992) Biochem. Cell Biol. 70, 1313-1318
28. Jicha, G. A., and Markesbery, W. R. (2010) Clin. Interv. Aging 5, 45-61
29. Kris-Etherton, P. M., Harris, W. S., and Appel, L. J. (2002) Circulation 106, 2747-2757
30. Price, P. T., Nelson, C. M., and Clarke, S. D. (2000) Curr. Opin. Lipidol. 11, 3-7
31. Watanabe, S., Doshi, M., and Hamazaki, T. (2003) Prostaglandins Leukot. Essent. Fatty Acids 69, 51-59
32. Colin, A., Reggers, J., Castronovo, V., and Ansseau, M. (2003) Encephale 29, 49-58
33. Stubbs, C. D., and Smith, A. D. (1990) Biochem. Soc. Trans. 18, 779-781
34. Mathias, S., Peña, L. A., and Kolesnick, R. N. (1998) Biochem. J. 335, 465-480
35. Horrobin, D. F., Jenkins, K., Bennett, C. N., and Christie, W. W. (2002) Prostaglandins Leukot Essent Fatty Acids 66, 83-90
36. Homan, R., Grossman, J. E., and Pownall, H. J. (1991) J. Lipid Res. 32, 231-241
37. Chiu, L. C., Wan, J. M., and Ooi, V. E. (2000) Int. J. Oncol. 17, 789-796
38. Malkowski, M. G., Ginell, S. L., Smith, W. L., and Garavito, R. M. (2000) Science 289, 1933-1937
39. Marcheselli, V. L., Hong, S., Lukiw, W. J., Tian, X. H., Gronert, K., Musto, A., Hardy, M., Gimenez, J. M., Chiang, N., Serhan, C. N., and Bazan, N. G. (2003) J. Biol. Chem. 278, 43807-43817
40. Calder, P. C. (2002) Proc. Nutr. Soc. 61, 345-358
41. Kuehl, F. A., Jr., and Egan, R. W. (1980) Science 210, 978-984
42. Huber, T., Rajamoorthi, K., Kurze, V. F., Beyer, K., and Brown, M. F. (2002) J. Am. Chem. Soc. 124, 298-309
43. Eldho, N. V., Feller, S. E., Tristram-Nagle, S., Polozov, I. V., and Gawrisch, K. (2003) J. Am. Chem. Soc. 125, 6409-6421
44. Serhan, C. N., Hong, S., Gronert, K., Colgan, S. P., Devchand, P. R., Mirick, G., and Moussignac, R. L. (2002) J. Exp. Med. 196, 1025-1037
45. Yagaloff, K. A., Franco, L., Simko, B., and Burghardt, B. (1995) Prostaglandins Leukot Essent Fatty Acids 52, 293-297
46. Lukiw, W. J., Cui, J. G., Marcheselli, V. L., Bodker, M., Botkjaer, A., Gotlinger, K., Serhan, C. N., and Bazan, N. G. (2005) J. Clin. Invest. 115, 2774-2783
47. Agren, J. J., Törmälä, M. L., Nenonen, M. T., and Hänninen, O. O. (1995) Lipids 30, 365-369
48. Sanders, T. A., and Younger, K. M. (1981) Br. J. Nutr. 45, 613-616
49. Pitman, M. C., Suits, F., Mackerell, A. D., Jr., and Feller, S. E. (2004) Biochemistry 43, 15318-15328