Eicosapentaenoic and docosahexaenoic acids are not anticonvulsant or neuroprotective in acute mouse seizure models

Epilepsia

Volumn 50, Issue 1, 2009, Pages 138-142

  Willis, Sarah ^a   Samala, Ramakrishna ^a   Rosenberger, Thad A ^b   Borges, Karin ^a  

^a TEXAS TECH UNIVERSITY HEALTH SCIENCES CENTER   (United States)

^b UNIVERSITY OF NORTH DAKOTA   (United States)

Author keywords

Epilepsy; Fluorothyl; Kainate; Pentylenetetrazole; Polyunsaturated fattyacid

Indexed keywords

DOCOSAHEXAENOIC ACID; FATTY ACID; FLUROTHYL; ICOSAPENTAENOIC ACID; KAINIC ACID; PENTETRAZOLE; VEGETABLE OIL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTICONVULSANT ACTIVITY; ARTICLE; BRAIN DAMAGE; CONTROLLED STUDY; EPILEPSY; FATTY ACID BLOOD LEVEL; FEEDING; HIPPOCAMPUS; MALE; MOUSE; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; SEIZURE; SEIZURE SUSCEPTIBILITY; SEIZURE THRESHOLD; TREATMENT OUTCOME;

ACUTE DISEASE; ANIMALS; BRAIN; DISEASE MODELS, ANIMAL; DOCOSAHEXAENOIC ACIDS; EICOSAPENTAENOIC ACID; MICE; SEIZURES;

EID: 58149234925     PISSN: 00139580     EISSN: 15281167     Source Type: Journal    
DOI: 10.1111/j.1528-1167.2008.01722.x     Document Type: Article

References (22)

1. Blondeau N, Widmann C, Lazdunski M, Heurteaux C 2002) Polyunsaturated fatty acids induce ischemic and epileptic tolerance. Neuroscience 109 : 231 241.
2. Borges K, Gearing M, McDermott DL, Smith AB, Almonte AG, Wainer BH, Dingledine R 2003) Neuronal and glial pathological changes during epileptogenesis in the mouse pilocarpine model. Exp Neurol 182 : 21 34.
3. Bromfield E, Dworetzky B, Hurwitz S, Eluri Z, Lane L, Replansky S, Mostofsky D 2008) A randomized trial of polyunsaturated fatty acids for refractory epilepsy. Epilepsy Behav 12 : 187 190.
4. Cunnane SC, Musa K, Ryan MA, Whiting S, Fraser DD 2002) Potential role of polyunsaturates in seizure protection achieved with the ketogenic diet. Prostaglandins Leukot Essent Fatty Acids 67 : 131 135.
5. Dahlin M, Hjelte L, Nilsson S, Amark P 2007) Plasma phospholipid fatty acids are influenced by a ketogenic diet enriched with n-3 fatty acids in children with epilepsy. Epilepsy Res 73 : 199 207.
6. Folch J, Lees M, Sloane Stanley GH 1957) A simple method for the isolation and purification of total lipides from animal tissue. J Biol Chem 226 : 497 509.
7. Hartman AL, Gasior M, Vining EP, Rogawski MA 2007) The neuropharmacology of the ketogenic diet. Pediatr Neurol 36 : 281 292.
8. Itokazu N, Ikegaya Y, Nishikawa M, Matsuki N 2000) Bidirectional actions of docosahexaenoic acid on hippocampal neurotransmissions in vivo. Brain Res 862 : 211 216.
9. Kimball AW, Burnett WT Jr., Doherty DG 1957) Chemical protection against ionizing radiation I. Sampling methods for screening compounds in radiation protection studies in mice. Radiat Res 7 : 1 12.
10. Leaf A, Kang JX, Xiao YF, Billman GE, Voskuyl RA 1999) The antiarrhythmic and anticonvulsant effects of dietary N-3 fatty acids. J Membr Biol 172 : 1 11.
11. McKhann GM 2nd., Wenzel HJ, Robbins CA, Sosunov AA, Schwartzkroin PA 2003) Mouse strain differences in kainic acid sensitivity, seizure behavior, mortality, and hippocampal pathology. Neuroscience 122 : 551 561.
12. Radin NS 1981) Extraction of tissue lipids with a solvent of low toxicity. Methods Enzymol 72 : 5 7.
13. Rho JM, Kim DW, Robbins CA, Anderson GD, Schwartzkroin PA 1999) Age-dependent differences in flurothyl seizure sensitivity in mice treated with a ketogenic diet. Epilepsy Res 37 : 233 240.
14. Rosenberger TA, Hovda JT, Peters JM 2002) Targeted disruption of peroxisomal proliferator-activated receptor beta (delta) results in distinct gender differences in mouse brain phospholipid and esterified FA levels. Lipids 37 : 495 500.
15. Samala R, Willis S, Borges K. (2008) Anticonvulsant profile of a balanced ketogenic diet in acute mouse seizure models. Epilepsy Res, in press.
16. Schauwecker PE 2002) Complications associated with genetic background effects in models of experimental epilepsy. Prog Brain Res 135 : 139 148.
17. Schlanger S, Shinitzky M, Yam D 2002) Diet enriched with omega-3 fatty acids alleviates convulsion symptoms in epilepsy patients. Epilepsia 43 : 103 104.
18. Taha AY, Baghiu BM, Lui R, Nylen K, Ma DW, Burnham WM 2006) Lack of benefit of linoleic and alpha-linolenic polyunsaturated fatty acids on seizure latency, duration, severity or incidence in rats. Epilepsy Res 71 : 40 46.
19. Voskuyl RA, Vreugdenhil M, Kang JX, Leaf A 1998) Anticonvulsant effect of polyunsaturated fatty acids in rats, using the cortical stimulation model. Eur J Pharmacol 341 : 145 152.
20. Xiao Y, Li X 1999) Polyunsaturated fatty acids modify mouse hippocampal neuronal excitability during excitotoxic or convulsant stimulation. Brain Res 846 : 112 121.
21. Yehuda S, Carasso RL, Mostofsky DI 1994) Essential fatty acid preparation (SR-3) raises the seizure threshold in rats. Eur J Pharmacol 254 : 193 198.
22. Yuen AW, Sander JW, Fluegel D, Patsalos PN, Bell GS, Johnson T, Koepp MJ 2005) Omega-3 fatty acid supplementation in patients with chronic epilepsy: a randomized trial. Epilepsy Behav 7 : 253 258.