메뉴 건너뛰기




Volumn 34, Issue 10, 2013, Pages 2271-2280

BRIT1 regulates p53 stability and functions as a tumor suppressor in breast cancer

Author keywords

[No Author keywords available]

Indexed keywords

BRCA1 C TERMINUS REPEAT INHIBITOR OF HUMAN TELOMERASE EXPRESSION 1 PROTEIN; PROTEIN MDM2; PROTEIN P53; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG;

EID: 84885128972     PISSN: 01433334     EISSN: 14602180     Source Type: Journal    
DOI: 10.1093/carcin/bgt190     Document Type: Article
Times cited : (14)

References (54)
  • 1
    • 0037821661 scopus 로고    scopus 로고
    • Multiple tumor suppressor pathways negatively regulate telomerase
    • Lin, S.Y. et al. (2003) Multiple tumor suppressor pathways negatively regulate telomerase. Cell, 113, 881-889.
    • (2003) Cell , vol.113 , pp. 881-889
    • Lin, S.Y.1
  • 2
    • 0032231397 scopus 로고    scopus 로고
    • Primary autosomal recessive microcephaly (MCPH1) maps to chromosome 8p22-pter
    • Jackson, A.P. et al. (1998) Primary autosomal recessive microcephaly (MCPH1) maps to chromosome 8p22-pter. Am. J. Hum. Genet., 63, 541-546.
    • (1998) Am. J. Hum. Genet. , vol.63 , pp. 541-546
    • Jackson, A.P.1
  • 3
    • 33746857684 scopus 로고    scopus 로고
    • BRIT1 regulates early DNA damage response, chromosomal integrity, and cancer
    • Rai, R. et al. (2006) BRIT1 regulates early DNA damage response, chromosomal integrity, and cancer. Cancer Cell, 10, 145-157.
    • (2006) Cancer Cell , vol.10 , pp. 145-157
    • Rai, R.1
  • 4
    • 37848999008 scopus 로고    scopus 로고
    • Distinct BRCT domains in MCPH1/BRIT1 mediate ionizing radiation-induced focus formation and centrosomal localization
    • Jeffers, L.J. et al. (2008) Distinct BRCT domains in MCPH1/BRIT1 mediate ionizing radiation-induced focus formation and centrosomal localization. Oncogene, 27, 139-144.
    • (2008) Oncogene , vol.27 , pp. 139-144
    • Jeffers, L.J.1
  • 5
    • 67650034511 scopus 로고    scopus 로고
    • BRIT1/MCPH1 links chromatin remodelling to DNA damage response
    • Peng, G. et al. (2009) BRIT1/MCPH1 links chromatin remodelling to DNA damage response. Nat. Cell Biol., 11, 865-872.
    • (2009) Nat. Cell Biol. , vol.11 , pp. 865-872
    • Peng, G.1
  • 6
    • 36849000716 scopus 로고    scopus 로고
    • MCPH1 functions in an H2AX-dependent but MDC1-independent pathway in response to DNA damage
    • Wood, J.L. et al. (2007) MCPH1 functions in an H2AX-dependent but MDC1-independent pathway in response to DNA damage. J. Biol. Chem., 282, 35416-35423.
    • (2007) J. Biol. Chem. , vol.282 , pp. 35416-35423
    • Wood, J.L.1
  • 7
    • 67650458507 scopus 로고    scopus 로고
    • Microcephalin regulates BRCA2 and Rad51-associated DNA double-strand break repair
    • Wu, X. et al. (2009) Microcephalin regulates BRCA2 and Rad51-associated DNA double-strand break repair. Cancer Res., 69, 5531-5536.
    • (2009) Cancer Res. , vol.69 , pp. 5531-5536
    • Wu, X.1
  • 8
    • 76749170775 scopus 로고    scopus 로고
    • BRIT1/MCPH1 is essential for mitotic and meiotic recombination DNA repair and maintaining genomic stability in mice
    • Liang, Y. et al. (2010) BRIT1/MCPH1 is essential for mitotic and meiotic recombination DNA repair and maintaining genomic stability in mice. PLoS Genet., 6, e1000826.
    • (2010) PLoS Genet. , vol.6
    • Liang, Y.1
  • 9
    • 0031046294 scopus 로고    scopus 로고
    • A superfamily of conserved domains in DNA damage responsive cell cycle checkpoint proteins
    • Bork, P. et al. (1997) A superfamily of conserved domains in DNA damage responsive cell cycle checkpoint proteins. FASEB J., 11, 68-76.
    • (1997) FASEB J. , vol.11 , pp. 68-76
    • Bork, P.1
  • 10
    • 79958279660 scopus 로고    scopus 로고
    • Microcephalin is a new novel prognostic indicator in breast cancer associated with BRCA1 inactivation
    • Richardson, J. et al. (2011) Microcephalin is a new novel prognostic indicator in breast cancer associated with BRCA1 inactivation. Breast Cancer Res. Treat., 127, 639-648.
    • (2011) Breast Cancer Res. Treat. , vol.127 , pp. 639-648
    • Richardson, J.1
  • 11
    • 85027955413 scopus 로고    scopus 로고
    • ASPM and microcephalin expression in epithelial ovarian cancer correlates with tumour grade and survival
    • Brüning-Richardson, A. et al. (2011) ASPM and microcephalin expression in epithelial ovarian cancer correlates with tumour grade and survival. Br. J. Cancer, 104, 1602-1610.
    • (2011) Br. J. Cancer , vol.104 , pp. 1602-1610
    • Brüning-Richardson, A.1
  • 12
    • 0035449355 scopus 로고    scopus 로고
    • Cell cycle checkpoint signaling through the ATM and ATR kinases
    • Abraham, R.T. (2001) Cell cycle checkpoint signaling through the ATM and ATR kinases. Genes Dev., 15, 2177-2196.
    • (2001) Genes Dev. , vol.15 , pp. 2177-2196
    • Abraham, R.T.1
  • 13
    • 0037365789 scopus 로고    scopus 로고
    • ATM and related protein kinases: safeguarding genome integrity
    • Shiloh, Y. (2003) ATM and related protein kinases: safeguarding genome integrity. Nat. Rev. Cancer, 3, 155-168.
    • (2003) Nat. Rev. Cancer , vol.3 , pp. 155-168
    • Shiloh, Y.1
  • 14
    • 3142534591 scopus 로고    scopus 로고
    • Initiating cellular stress responses
    • Bakkenist, C.J. et al. (2004) Initiating cellular stress responses. Cell, 118, 9-17.
    • (2004) Cell , vol.118 , pp. 9-17
    • Bakkenist, C.J.1
  • 15
    • 1542725073 scopus 로고    scopus 로고
    • Targeting the checkpoint kinases: chemosensitization versus chemoprotection
    • Zhou, B.B. et al. (2004) Targeting the checkpoint kinases: chemosensitization versus chemoprotection. Nat. Rev. Cancer, 4, 216-225.
    • (2004) Nat. Rev. Cancer , vol.4 , pp. 216-225
    • Zhou, B.B.1
  • 16
    • 0035902108 scopus 로고    scopus 로고
    • Genome maintenance mechanisms for preventing cancer
    • Hoeijmakers, J.H. (2001) Genome maintenance mechanisms for preventing cancer. Nature, 411, 366-374.
    • (2001) Nature , vol.411 , pp. 366-374
    • Hoeijmakers, J.H.1
  • 17
    • 27244445051 scopus 로고    scopus 로고
    • BRIT1/MCPH1 is a DNA damage responsive protein that regulates the Brca1-Chk1 pathway, implicating checkpoint dysfunction in microcephaly
    • Lin, S.Y. et al. (2005) BRIT1/MCPH1 is a DNA damage responsive protein that regulates the Brca1-Chk1 pathway, implicating checkpoint dysfunction in microcephaly. Proc. Natl Acad. Sci. USA, 102, 15105-15109.
    • (2005) Proc. Natl Acad. Sci. USA , vol.102 , pp. 15105-15109
    • Lin, S.Y.1
  • 18
    • 4544269236 scopus 로고    scopus 로고
    • Microcephalin is a DNA damage response protein involved in regulation of CHK1 and BRCA1
    • Xu, X. et al. (2004) Microcephalin is a DNA damage response protein involved in regulation of CHK1 and BRCA1. J. Biol. Chem., 279, 34091-34094.
    • (2004) J. Biol. Chem. , vol.279 , pp. 34091-34094
    • Xu, X.1
  • 19
    • 33745763425 scopus 로고    scopus 로고
    • Regulation of mitotic entry by microcephalin and its overlap with ATR signalling
    • Alderton, G.K. et al. (2006) Regulation of mitotic entry by microcephalin and its overlap with ATR signalling. Nat. Cell Biol., 8, 725-733.
    • (2006) Nat. Cell Biol. , vol.8 , pp. 725-733
    • Alderton, G.K.1
  • 20
    • 10944224673 scopus 로고    scopus 로고
    • INO80 and gamma-H2AX interaction links ATP-dependent chromatin remodeling to DNA damage repair
    • Morrison, A.J. et al. (2004) INO80 and gamma-H2AX interaction links ATP-dependent chromatin remodeling to DNA damage repair. Cell, 119, 767-775.
    • (2004) Cell , vol.119 , pp. 767-775
    • Morrison, A.J.1
  • 21
    • 10944233962 scopus 로고    scopus 로고
    • Recruitment of the INO80 complex by H2A phosphorylation links ATP-dependent chromatin remodeling with DNA double-strand break repair
    • van Attikum, H. et al. (2004) Recruitment of the INO80 complex by H2A phosphorylation links ATP-dependent chromatin remodeling with DNA double-strand break repair. Cell, 119, 777-788.
    • (2004) Cell , vol.119 , pp. 777-788
    • van Attikum, H.1
  • 22
    • 0032039077 scopus 로고    scopus 로고
    • Meiotic prophase arrest with failure of chromosome synapsis in mice deficient for Dmc1, a germline-specific RecA homolog
    • Pittman, D.L. et al. (1998) Meiotic prophase arrest with failure of chromosome synapsis in mice deficient for Dmc1, a germline-specific RecA homolog. Mol. Cell, 1, 697-705.
    • (1998) Mol. Cell , vol.1 , pp. 697-705
    • Pittman, D.L.1
  • 23
    • 0032037422 scopus 로고    scopus 로고
    • The mouse RecA-like gene Dmc1 is required for homologous chromosome synapsis during meiosis
    • Yoshida, K. et al. (1998) The mouse RecA-like gene Dmc1 is required for homologous chromosome synapsis during meiosis. Mol. Cell, 1, 707-718.
    • (1998) Mol. Cell , vol.1 , pp. 707-718
    • Yoshida, K.1
  • 24
    • 0037096937 scopus 로고    scopus 로고
    • High-density allelotyping of chromosome 8p in hepatocellular carcinoma and clinicopathologic correlation
    • Chan, K. et al. (2002) High-density allelotyping of chromosome 8p in hepatocellular carcinoma and clinicopathologic correlation. Cancer, 94, 3179-3185.
    • (2002) Cancer , vol.94 , pp. 3179-3185
    • Chan, K.1
  • 25
    • 0037444031 scopus 로고    scopus 로고
    • Pathological and molecular aspects of prostate cancer
    • DeMarzo, A.M. et al. (2003) Pathological and molecular aspects of prostate cancer. Lancet, 361, 955-964.
    • (2003) Lancet , vol.361 , pp. 955-964
    • DeMarzo, A.M.1
  • 26
    • 0035048994 scopus 로고    scopus 로고
    • Comparison of serous and mucinous ovarian carcinomas: distinct pattern of allelic loss at distal 8p and expression of transcription factor GATA-4
    • Lassus, H. et al. (2001) Comparison of serous and mucinous ovarian carcinomas: distinct pattern of allelic loss at distal 8p and expression of transcription factor GATA-4. Lab. Invest., 81, 517-526.
    • (2001) Lab. Invest. , vol.81 , pp. 517-526
    • Lassus, H.1
  • 27
    • 0142059657 scopus 로고    scopus 로고
    • Pooled analysis of loss of heterozygosity in breast cancer: a genome scan provides comparative evidence for multiple tumor suppressors and identifies novel candidate regions
    • Miller, B.J. et al. (2003) Pooled analysis of loss of heterozygosity in breast cancer: a genome scan provides comparative evidence for multiple tumor suppressors and identifies novel candidate regions. Am. J. Hum. Genet., 73, 748-767.
    • (2003) Am. J. Hum. Genet. , vol.73 , pp. 748-767
    • Miller, B.J.1
  • 28
    • 0034902573 scopus 로고    scopus 로고
    • High frequency of allelic imbalance at regions of chromosome arm 8p in ovarian carcinoma
    • Pribill, I. et al. (2001) High frequency of allelic imbalance at regions of chromosome arm 8p in ovarian carcinoma. Cancer Genet. Cytogenet., 129, 23-29.
    • (2001) Cancer Genet. Cytogenet. , vol.129 , pp. 23-29
    • Pribill, I.1
  • 29
    • 0034547268 scopus 로고    scopus 로고
    • Genome-wide allelotype analysis of sporadic primary nasopharyngeal carcinoma from southern China
    • Shao, J.Y. et al. (2000) Genome-wide allelotype analysis of sporadic primary nasopharyngeal carcinoma from southern China. Int. J. Oncol., 17, 1267-1275.
    • (2000) Int. J. Oncol. , vol.17 , pp. 1267-1275
    • Shao, J.Y.1
  • 30
    • 0036320867 scopus 로고    scopus 로고
    • Invasive micropapillary carcinoma of the breast is associated with chromosome 8 abnormalities detected by comparative genomic hybridization
    • Thor, A. et al. (2002) Invasive micropapillary carcinoma of the breast is associated with chromosome 8 abnormalities detected by comparative genomic hybridization. Hum. Pathol., 33, 628-631.
    • (2002) Hum. Pathol. , vol.33 , pp. 628-631
    • Thor, A.1
  • 31
    • 0037905690 scopus 로고    scopus 로고
    • Array-based comparative genomic hybridization for genome-wide screening of DNA copy number in bladder tumors
    • Veltman, J. et al. (2003) Array-based comparative genomic hybridization for genome-wide screening of DNA copy number in bladder tumors. Cancer Res., 63, 2872-2880.
    • (2003) Cancer Res. , vol.63 , pp. 2872-2880
    • Veltman, J.1
  • 32
    • 33751218297 scopus 로고    scopus 로고
    • BRIT1/MCPH1: a guardian of genome and an enemy of tumors
    • Chaplet, M. et al. (2006) BRIT1/MCPH1: a guardian of genome and an enemy of tumors. Cell Cycle, 22, 2579-2583.
    • (2006) Cell Cycle , vol.22 , pp. 2579-2583
    • Chaplet, M.1
  • 33
    • 84857192718 scopus 로고    scopus 로고
    • Causes and consequences of aneuploidy in cancer
    • Gordon, D.J. et al. (2012) Causes and consequences of aneuploidy in cancer. Nat. Rev. Genet., 13, 189-203.
    • (2012) Nat. Rev. Genet. , vol.13 , pp. 189-203
    • Gordon, D.J.1
  • 34
    • 80052146061 scopus 로고    scopus 로고
    • Chromatin and the DNA damage response: the cancer connection
    • Luijsterburg, M.S. et al. (2011) Chromatin and the DNA damage response: the cancer connection. Mol. Oncol., 5, 349-367.
    • (2011) Mol. Oncol. , vol.5 , pp. 349-367
    • Luijsterburg, M.S.1
  • 35
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: the next generation
    • Hanahan, D. et al. (2011) Hallmarks of cancer: the next generation. Cell, 144, 646-676.
    • (2011) Cell , vol.144 , pp. 646-676
    • Hanahan, D.1
  • 36
    • 51049100399 scopus 로고    scopus 로고
    • MCPH1/BRIT1 cooperates with E2F1 in the activation of checkpoint, DNA repair and apoptosis
    • Yang, S.Z. et al. (2008) MCPH1/BRIT1 cooperates with E2F1 in the activation of checkpoint, DNA repair and apoptosis. EMBO Rep., 9, 907-915.
    • (2008) EMBO Rep. , vol.9 , pp. 907-915
    • Yang, S.Z.1
  • 37
    • 70349442548 scopus 로고    scopus 로고
    • The first 30 years of p53: growing ever more complex
    • Levine, A.J. et al. (2009) The first 30 years of p53: growing ever more complex. Nat. Rev. Cancer, 9, 749-758.
    • (2009) Nat. Rev. Cancer , vol.9 , pp. 749-758
    • Levine, A.J.1
  • 38
    • 65349103899 scopus 로고    scopus 로고
    • Blinded by the light: the growing complexity of p53
    • Vousden, K.H. et al. (2009) Blinded by the light: the growing complexity of p53. Cell, 137, 413-431.
    • (2009) Cell , vol.137 , pp. 413-431
    • Vousden, K.H.1
  • 39
    • 33646807491 scopus 로고    scopus 로고
    • Transcriptional regulation by p53: one protein, many possibilities
    • Laptenko, O. et al. (2006) Transcriptional regulation by p53: one protein, many possibilities. Cell Death Differ., 13, 951-961.
    • (2006) Cell Death Differ. , vol.13 , pp. 951-961
    • Laptenko, O.1
  • 40
    • 0025193635 scopus 로고
    • Transcriptional activation by wild-type but not transforming mutants of the p53 anti-oncogene
    • Raycroft, L. et al. (1990) Transcriptional activation by wild-type but not transforming mutants of the p53 anti-oncogene. Science, 249, 1049-1051.
    • (1990) Science , vol.249 , pp. 1049-1051
    • Raycroft, L.1
  • 41
    • 65549120715 scopus 로고    scopus 로고
    • Modes of p53 regulation
    • Kruse, J.P. et al. (2009) Modes of p53 regulation. Cell, 137, 609-622.
    • (2009) Cell , vol.137 , pp. 609-622
    • Kruse, J.P.1
  • 42
    • 33947534030 scopus 로고    scopus 로고
    • p53 in health and disease
    • Vousden, K.H. et al. (2007) p53 in health and disease. Nat. Rev. Mol. Cell Biol., 8, 275-283.
    • (2007) Nat. Rev. Mol. Cell Biol. , vol.8 , pp. 275-283
    • Vousden, K.H.1
  • 43
    • 0027459198 scopus 로고
    • MDM2 expression is induced by wild type p53 activity
    • Barak, Y. et al. (1993) MDM2 expression is induced by wild type p53 activity. EMBO J., 12, 461-468.
    • (1993) EMBO J. , vol.12 , pp. 461-468
    • Barak, Y.1
  • 44
    • 77955871461 scopus 로고    scopus 로고
    • The MDM2-p53 relationship evolves: MDM2 swings both ways as an oncogene and a tumor suppressor
    • Manfredi, J.J. (2010) The MDM2-p53 relationship evolves: MDM2 swings both ways as an oncogene and a tumor suppressor. Genes Dev., 24, 1580-1589.
    • (2010) Genes Dev. , vol.24 , pp. 1580-1589
    • Manfredi, J.J.1
  • 45
    • 77952543499 scopus 로고    scopus 로고
    • The p53 orchestra: MDM2 and MDMX set the tone
    • Wade, M. et al. (2010) The p53 orchestra: MDM2 and MDMX set the tone. Trends Cell Biol., 20, 299-309.
    • (2010) Trends Cell Biol. , vol.20 , pp. 299-309
    • Wade, M.1
  • 46
    • 0033552595 scopus 로고    scopus 로고
    • Regulation of p53 in response to DNA damage
    • Lakin, N.D. et al. (1999) Regulation of p53 in response to DNA damage. Oncogene, 18, 7644-7655.
    • (1999) Oncogene , vol.18 , pp. 7644-7655
    • Lakin, N.D.1
  • 47
    • 18344377030 scopus 로고    scopus 로고
    • The p53 pathway: positive and negative feedback loops
    • Harris, S.L. et al. (2005) The p53 pathway: positive and negative feedback loops. Oncogene, 24, 2899-2908.
    • (2005) Oncogene , vol.24 , pp. 2899-2908
    • Harris, S.L.1
  • 48
    • 0035841951 scopus 로고    scopus 로고
    • Genotoxic and non-genotoxic pathways of p53 induction
    • Pluquet, O. et al. (2001) Genotoxic and non-genotoxic pathways of p53 induction. Cancer Lett., 174, 1-15.
    • (2001) Cancer Lett. , vol.174 , pp. 1-15
    • Pluquet, O.1
  • 49
    • 33646757232 scopus 로고    scopus 로고
    • The complexity of p53 stabilization and activation
    • Lavin, M.F. et al. (2006) The complexity of p53 stabilization and activation. Cell Death Differ., 13, 941-950.
    • (2006) Cell Death Differ. , vol.13 , pp. 941-950
    • Lavin, M.F.1
  • 50
    • 70450260576 scopus 로고    scopus 로고
    • CK1a plays a central role in mediating MDM2 control of p53 and E2F-1 protein stability
    • Huart, A.-S. et al. (2009) CK1a plays a central role in mediating MDM2 control of p53 and E2F-1 protein stability. J. Biol. Chem., 284, 32384-32394.
    • (2009) J. Biol. Chem. , vol.284 , pp. 32384-32394
    • Huart, A.-S.1
  • 51
    • 17244367849 scopus 로고    scopus 로고
    • DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis
    • Barkova, J. et al. (2005) DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis. Nature, 434, 864-870.
    • (2005) Nature , vol.434 , pp. 864-870
    • Barkova, J.1
  • 52
    • 33845269825 scopus 로고    scopus 로고
    • Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication
    • Di Micco, R. et al. (2006) Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication. Nature, 444, 638-642.
    • (2006) Nature , vol.444 , pp. 638-642
    • Di Micco, R.1
  • 53
    • 4043181214 scopus 로고    scopus 로고
    • Cancer genes and the pathways they control
    • Vogelstein, B. et al. (2004) Cancer genes and the pathways they control. Nat. Med., 10, 789-799.
    • (2004) Nat. Med. , vol.10 , pp. 789-799
    • Vogelstein, B.1
  • 54
    • 70349443284 scopus 로고    scopus 로고
    • When mutants gain new powers: news from the mutant p53 field
    • Brosh, R. et al. (2009) When mutants gain new powers: news from the mutant p53 field. Nat. Rev. Cancer, 9, 701-713.
    • (2009) Nat. Rev. Cancer , vol.9 , pp. 701-713
    • Brosh, R.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.