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Volumn 170, Issue 4, 2013, Pages 712-729

Angiogenesis inhibitors in cancer therapy: Mechanistic perspective on classification and treatment rationales

Author keywords

angiogenesis inhibitors; cancer therapy; tumour micro environment

Indexed keywords

ACETYLSALICYLIC ACID; ANGIOGENESIS INHIBITOR; ANTINEOPLASTIC AGENT; AXITINIB; AZD 4547; BEVACIZUMAB; BORTEZOMIB; CARBOPLATIN; CELECOXIB; CILENGITIDE; CYCLOPHOSPHAMIDE; DACINOSTAT; DOCETAXEL; FLUOROURACIL; GOSSYPOL; IBUPROFEN; IMATINIB; ORANTINIB; PACLITAXEL; RABEPRAZOLE; REPARIXIN; SORAFENIB; SUNITINIB; TIPIFARNIB; UNINDEXED DRUG; VANDETANIB; VASCULOTROPIN; VATALANIB; VOLOCIXIMAB; ZOLEDRONIC ACID;

EID: 84885106382     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/bph.12344     Document Type: Review
Times cited : (204)

References (243)
  • 2
    • 24344434550 scopus 로고    scopus 로고
    • Inhibition of alpha(v)beta3 integrin survival signaling enhances antiangiogenic and antitumor effects of radiotherapy
    • Abdollahi A, Griggs DW, Zieher H, Roth A, Lipson KE, Saffrich R, et al. (2005). Inhibition of alpha(v)beta3 integrin survival signaling enhances antiangiogenic and antitumor effects of radiotherapy. Clin Cancer Res 11: 6270-6279.
    • (2005) Clin Cancer Res , vol.11 , pp. 6270-6279
    • Abdollahi, A.1    Griggs, D.W.2    Zieher, H.3    Roth, A.4    Lipson, K.E.5    Saffrich, R.6
  • 3
    • 28244456279 scopus 로고    scopus 로고
    • Tumor inflammatory angiogenesis and its chemoprevention
    • Albini A, Tosetti F, Benelli R, Noonan DM, (2005). Tumor inflammatory angiogenesis and its chemoprevention. Cancer Res 65: 10637-10641.
    • (2005) Cancer Res , vol.65 , pp. 10637-10641
    • Albini, A.1    Tosetti, F.2    Benelli, R.3    Noonan, D.M.4
  • 4
    • 59949099437 scopus 로고    scopus 로고
    • Diabetic retinopathy: Current management and experimental therapeutic targets
    • Ali TK, El-Remessy AB, (2009). Diabetic retinopathy: current management and experimental therapeutic targets. Pharmacotherapy 29: 182-192.
    • (2009) Pharmacotherapy , vol.29 , pp. 182-192
    • Ali, T.K.1    El-Remessy, A.B.2
  • 5
    • 80051690789 scopus 로고    scopus 로고
    • Brivanib, a dual FGF/VEGF inhibitor, is active both first and second line against mouse pancreatic neuroendocrine tumors developing adaptive/evasive resistance to VEGF inhibition
    • Allen E, Walters IB, Hanahan D, (2011). Brivanib, a dual FGF/VEGF inhibitor, is active both first and second line against mouse pancreatic neuroendocrine tumors developing adaptive/evasive resistance to VEGF inhibition. Clin Cancer Res 17: 5299-5310.
    • (2011) Clin Cancer Res , vol.17 , pp. 5299-5310
    • Allen, E.1    Walters, I.B.2    Hanahan, D.3
  • 6
    • 84874851836 scopus 로고    scopus 로고
    • Phase i study of dovitinib (TKI258), an oral FGFR, VEGFR, and PDGFR inhibitor, in advanced or metastatic renal cell carcinoma
    • Angevin E, Lopez-Martin JA, Lin C-C, Gschwend E Jr, Harzstark A, Castellano D, et al. (2013). Phase I study of dovitinib (TKI258), an oral FGFR, VEGFR, and PDGFR inhibitor, in advanced or metastatic renal cell carcinoma. Clin Cancer Res 19: 1257-1268.
    • (2013) Clin Cancer Res , vol.19 , pp. 1257-1268
    • Angevin, E.1    Lopez-Martin, J.A.2    Lin, C.-C.3    Gschwend, Jr.E.4    Harzstark, A.5    Castellano, D.6
  • 7
    • 0031745571 scopus 로고    scopus 로고
    • Signal transduction and signal modulation by cell adhesion receptors: The role of integrins, cadherins, immunoglobulin-cell adhesion molecules, and selectins
    • Aplin AE, Howe A, Alahari SK, Juliano RL, (1998). Signal transduction and signal modulation by cell adhesion receptors: the role of integrins, cadherins, immunoglobulin-cell adhesion molecules, and selectins. Pharmacol Rev 50: 197-263.
    • (1998) Pharmacol Rev , vol.50 , pp. 197-263
    • Aplin, A.E.1    Howe, A.2    Alahari, S.K.3    Juliano, R.L.4
  • 8
    • 39749140405 scopus 로고    scopus 로고
    • HIF-independent regulation of VEGF and angiogenesis by the transcriptional coactivator PGC-1alpha
    • Arany Z, Foo SY, Ma Y, Ruas JL, Bommi-Reddy A, Girnun G, et al. (2008). HIF-independent regulation of VEGF and angiogenesis by the transcriptional coactivator PGC-1alpha. Nature 451: 1008-1012.
    • (2008) Nature , vol.451 , pp. 1008-1012
    • Arany, Z.1    Foo, S.Y.2    Ma, Y.3    Ruas, J.L.4    Bommi-Reddy, A.5    Girnun, G.6
  • 9
    • 79952741923 scopus 로고    scopus 로고
    • Phase II trial of pemetrexed and bevacizumab in patients with recurrent or metastatic head and neck cancer
    • Argiris A, Karamouzis MV, Gooding WE, Branstetter BF, Zhong S, Raez LE, et al. (2011). Phase II trial of pemetrexed and bevacizumab in patients with recurrent or metastatic head and neck cancer. J Clin Oncol 29: 1140-1145.
    • (2011) J Clin Oncol , vol.29 , pp. 1140-1145
    • Argiris, A.1    Karamouzis, M.V.2    Gooding, W.E.3    Branstetter, B.F.4    Zhong, S.5    Raez, L.E.6
  • 10
    • 84871554687 scopus 로고    scopus 로고
    • Cetuximab and bevacizumab: Preclinical data and phase II trial in recurrent or metastatic squamous cell carcinoma of the head and neck
    • Argiris A, Kotsakis AP, Hoang T, Worden FP, Savvides P, Gibson MK, et al. (2013). Cetuximab and bevacizumab: preclinical data and phase II trial in recurrent or metastatic squamous cell carcinoma of the head and neck. Ann Oncol 24: 220-225.
    • (2013) Ann Oncol , vol.24 , pp. 220-225
    • Argiris, A.1    Kotsakis, A.P.2    Hoang, T.3    Worden, F.P.4    Savvides, P.5    Gibson, M.K.6
  • 11
    • 0036848118 scopus 로고    scopus 로고
    • Phase i and pharmacological study of the oral farnesyl transferase inhibitor SCH 66336 given once daily to patients with advanced solid tumours
    • Awada A, Eskens FA, Piccart M, Cutler DL, van der Gaast A, Bleiberg H, et al. (2002). Phase I and pharmacological study of the oral farnesyl transferase inhibitor SCH 66336 given once daily to patients with advanced solid tumours. Eur J Cancer 38: 2272-2278.
    • (2002) Eur J Cancer , vol.38 , pp. 2272-2278
    • Awada, A.1    Eskens, F.A.2    Piccart, M.3    Cutler, D.L.4    Van Der Gaast, A.5    Bleiberg, H.6
  • 12
    • 70549112270 scopus 로고    scopus 로고
    • The angiogenic switch in carcinogenesis
    • Baeriswyl V, Christofori G, (2009). The angiogenic switch in carcinogenesis. Semin Cancer Biol 19: 329-337.
    • (2009) Semin Cancer Biol , vol.19 , pp. 329-337
    • Baeriswyl, V.1    Christofori, G.2
  • 13
    • 33751413349 scopus 로고    scopus 로고
    • A review of the latest clinical compounds to inhibit VEGF in pathological angiogenesis
    • Baka S, Clamp AR, Jayson GC, (2006). A review of the latest clinical compounds to inhibit VEGF in pathological angiogenesis. Expert Opin Ther Targets 10: 867-876.
    • (2006) Expert Opin Ther Targets , vol.10 , pp. 867-876
    • Baka, S.1    Clamp, A.R.2    Jayson, G.C.3
  • 14
    • 17644394616 scopus 로고    scopus 로고
    • Smoldering and polarized inflammation in the initiation and promotion of malignant disease
    • Balkwill F, Charles KA, Mantovani A, (2005). Smoldering and polarized inflammation in the initiation and promotion of malignant disease. Cancer Cell 7: 211-217.
    • (2005) Cancer Cell , vol.7 , pp. 211-217
    • Balkwill, F.1    Charles, K.A.2    Mantovani, A.3
  • 15
    • 0036733776 scopus 로고    scopus 로고
    • Suppression of 7,12-dimethylbenz(a)anthracene-induced mammary carcinogenesis in rats by resveratrol: Role of nuclear factor-kappaB, cyclooxygenase 2, and matrix metalloprotease 9
    • Banerjee S, Bueso-Ramos C, Aggarwal BB, (2002). Suppression of 7,12-dimethylbenz(a)anthracene-induced mammary carcinogenesis in rats by resveratrol: role of nuclear factor-kappaB, cyclooxygenase 2, and matrix metalloprotease 9. Cancer Res 62: 4945-4954.
    • (2002) Cancer Res , vol.62 , pp. 4945-4954
    • Banerjee, S.1    Bueso-Ramos, C.2    Aggarwal, B.B.3
  • 16
    • 84874045033 scopus 로고    scopus 로고
    • The tyrosine kinase inhibitor E-3810 combined with paclitaxel inhibits the growth of advanced-stage triple-negative breast cancer xenografts
    • Bello E, Taraboletti G, Colella G, Zucchetti M, Forestieri D, Licandro SA, et al. (2013). The tyrosine kinase inhibitor E-3810 combined with paclitaxel inhibits the growth of advanced-stage triple-negative breast cancer xenografts. Mol Cancer Ther 12: 131-140.
    • (2013) Mol Cancer Ther , vol.12 , pp. 131-140
    • Bello, E.1    Taraboletti, G.2    Colella, G.3    Zucchetti, M.4    Forestieri, D.5    Licandro, S.A.6
  • 17
    • 0037967272 scopus 로고    scopus 로고
    • Tumorigenesis and the angiogenic switch
    • Bergers G, Benjamin LE, (2003). Tumorigenesis and the angiogenic switch. Nat Rev Cancer 3: 401-410.
    • (2003) Nat Rev Cancer , vol.3 , pp. 401-410
    • Bergers, G.1    Benjamin, L.E.2
  • 18
    • 47949099628 scopus 로고    scopus 로고
    • Modes of resistance to anti-angiogenic therapy
    • Bergers G, Hanahan D, (2008). Modes of resistance to anti-angiogenic therapy. Nat Rev Cancer 8: 592-603.
    • (2008) Nat Rev Cancer , vol.8 , pp. 592-603
    • Bergers, G.1    Hanahan, D.2
  • 19
    • 0000391746 scopus 로고    scopus 로고
    • Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis
    • Bergers G, Brekken R, McMahon G, Vu TH, Itoh T, Tamaki K, et al. (2000). Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis. Nat Cell Biol 2: 737-744.
    • (2000) Nat Cell Biol , vol.2 , pp. 737-744
    • Bergers, G.1    Brekken, R.2    McMahon, G.3    Vu, T.H.4    Itoh, T.5    Tamaki, K.6
  • 21
    • 84871568127 scopus 로고    scopus 로고
    • Phase Ib safety and pharmacokinetic study of volociximab, an anti-alpha5beta1 integrin antibody, in combination with carboplatin and paclitaxel in advanced non-small-cell lung cancer
    • Besse B, Tsao LC, Chao DT, Fang Y, Soria JC, Almokadem S, et al. (2013). Phase Ib safety and pharmacokinetic study of volociximab, an anti-alpha5beta1 integrin antibody, in combination with carboplatin and paclitaxel in advanced non-small-cell lung cancer. Ann Oncol 24: 90-96.
    • (2013) Ann Oncol , vol.24 , pp. 90-96
    • Besse, B.1    Tsao, L.C.2    Chao, D.T.3    Fang, Y.4    Soria, J.C.5    Almokadem, S.6
  • 22
    • 84859406516 scopus 로고    scopus 로고
    • Potent inhibition of angiogenesis by the IGF-1 receptor-targeting antibody SCH717454 is reversed by IGF-2
    • Bid HK, Zhan J, Phelps DA, Kurmasheva RT, Houghton PJ, (2011). Potent inhibition of angiogenesis by the IGF-1 receptor-targeting antibody SCH717454 is reversed by IGF-2. Mol Cancer Ther 11: 649-659.
    • (2011) Mol Cancer Ther , vol.11 , pp. 649-659
    • Bid, H.K.1    Zhan, J.2    Phelps, D.A.3    Kurmasheva, R.T.4    Houghton, P.J.5
  • 23
    • 0031470620 scopus 로고    scopus 로고
    • Cell adhesion and angiogenesis
    • Bischoff J, (1997). Cell adhesion and angiogenesis. J Clin Invest 100 (Suppl. 11): S37-S39.
    • (1997) J Clin Invest , vol.100 , Issue.SUPPL. 11
    • Bischoff, J.1
  • 24
    • 77955123488 scopus 로고    scopus 로고
    • A phase i study of Vandetanib in combination with vinorelbine/cisplatin or gemcitabine/cisplatin as first-line treatment for advanced non-small cell lung cancer
    • Blackhall FH, O'Brien M, Schmid P, Nicolson M, Taylor P, Milenkova T, et al. (2010). A phase I study of Vandetanib in combination with vinorelbine/cisplatin or gemcitabine/cisplatin as first-line treatment for advanced non-small cell lung cancer. J Thorac Oncol 5: 1285-1288.
    • (2010) J Thorac Oncol , vol.5 , pp. 1285-1288
    • Blackhall, F.H.1    O'Brien, M.2    Schmid, P.3    Nicolson, M.4    Taylor, P.5    Milenkova, T.6
  • 25
    • 84887319864 scopus 로고    scopus 로고
    • Further observations concerning the effects of the N-cadherin antagonist ExherinTM (ADH-1) on endothelial cells and tumor blood vessels
    • Blaschuk O, Lavoie N, Devamy E, Lepekhin E, (2005). Further observations concerning the effects of the N-cadherin antagonist ExherinTM (ADH-1) on endothelial cells and tumor blood vessels. AACR Meeting Abstracts 2005 (1): 268.
    • (2005) AACR Meeting Abstracts , Issue.1 , pp. 268
    • Blaschuk, O.1    Lavoie, N.2    Devamy, E.3    Lepekhin, E.4
  • 26
    • 84862767410 scopus 로고    scopus 로고
    • Discovery and development of N-cadherin antagonists
    • Blaschuk OW, (2012). Discovery and development of N-cadherin antagonists. Cell Tissue Res 348: 309-313.
    • (2012) Cell Tissue Res , vol.348 , pp. 309-313
    • Blaschuk, O.W.1
  • 27
    • 84876355112 scopus 로고    scopus 로고
    • Inhibition of tumor angiogenesis and growth by a small-molecule multi-FGF receptor blocker with allosteric properties
    • Bono F, De Smet F, Herbert C, De Bock K, Georgiadou M, Fons P, et al. (2013). Inhibition of tumor angiogenesis and growth by a small-molecule multi-FGF receptor blocker with allosteric properties. Cancer Cell 23: 477-488.
    • (2013) Cancer Cell , vol.23 , pp. 477-488
    • Bono, F.1    De Smet, F.2    Herbert, C.3    De Bock, K.4    Georgiadou, M.5    Fons, P.6
  • 28
    • 29344440476 scopus 로고    scopus 로고
    • A review on pro- and anti-angiogenic factors as targets of clinical intervention
    • Bouis D, Kusumanto Y, Meijer C, Mulder NH, Hospers GAP, (2006). A review on pro- and anti-angiogenic factors as targets of clinical intervention. Pharmacol Res 53: 89-103.
    • (2006) Pharmacol Res , vol.53 , pp. 89-103
    • Bouis, D.1    Kusumanto, Y.2    Meijer, C.3    Mulder, N.H.4    Hospers, G.A.P.5
  • 29
    • 77956301181 scopus 로고    scopus 로고
    • Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs): Positive and negative regulators in tumor cell adhesion
    • Bourboulia D, Stetler-Stevenson WG, (2010). Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs): positive and negative regulators in tumor cell adhesion. Semin Cancer Biol 20: 161-168.
    • (2010) Semin Cancer Biol , vol.20 , pp. 161-168
    • Bourboulia, D.1    Stetler-Stevenson, W.G.2
  • 30
    • 84866096019 scopus 로고    scopus 로고
    • Targeting carcinoma-associated fibroblasts within the tumor stroma with a fibroblast activation protein-activated prodrug
    • Brennen WN, Rosen DM, Wang H, Isaacs JT, Denmeade SR, (2012). Targeting carcinoma-associated fibroblasts within the tumor stroma with a fibroblast activation protein-activated prodrug. J Natl Cancer Inst 104: 1320-1334.
    • (2012) J Natl Cancer Inst , vol.104 , pp. 1320-1334
    • Brennen, W.N.1    Rosen, D.M.2    Wang, H.3    Isaacs, J.T.4    Denmeade, S.R.5
  • 31
    • 84878235787 scopus 로고    scopus 로고
    • Dose selection trial of metronomic oral vinorelbine monotherapy in patients with metastatic cancer: A hellenic cooperative oncology group clinical translational study
    • Briasoulis E, Aravantinos G, Kouvatseas G, Pappas P, Biziota E, Sainis I, et al. (2013). Dose selection trial of metronomic oral vinorelbine monotherapy in patients with metastatic cancer: a hellenic cooperative oncology group clinical translational study. BMC Cancer 13: 263.
    • (2013) BMC Cancer , vol.13 , pp. 263
    • Briasoulis, E.1    Aravantinos, G.2    Kouvatseas, G.3    Pappas, P.4    Biziota, E.5    Sainis, I.6
  • 33
    • 79953848263 scopus 로고    scopus 로고
    • Bevacizumab for advanced breast cancer: All tied up with a RIBBON?
    • Burstein HJ, (2011). Bevacizumab for advanced breast cancer: all tied up with a RIBBON? J Clin Oncol 29: 1232-1235.
    • (2011) J Clin Oncol , vol.29 , pp. 1232-1235
    • Burstein, H.J.1
  • 34
    • 0037699955 scopus 로고    scopus 로고
    • Angiogenesis in health and disease
    • Carmeliet P, (2003). Angiogenesis in health and disease. Nat Med 9: 653-660.
    • (2003) Nat Med , vol.9 , pp. 653-660
    • Carmeliet, P.1
  • 35
    • 30744479430 scopus 로고    scopus 로고
    • Angiogenesis in life, disease and medicine
    • Carmeliet P, (2005). Angiogenesis in life, disease and medicine. Nature 438: 932-936.
    • (2005) Nature , vol.438 , pp. 932-936
    • Carmeliet, P.1
  • 36
    • 26644471951 scopus 로고    scopus 로고
    • Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in late-stage pancreatic islet tumors
    • Casanovas O, Hicklin DJ, Bergers G, Hanahan D, (2005). Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in late-stage pancreatic islet tumors. Cancer Cell 8: 299-309.
    • (2005) Cancer Cell , vol.8 , pp. 299-309
    • Casanovas, O.1    Hicklin, D.J.2    Bergers, G.3    Hanahan, D.4
  • 38
    • 84872744595 scopus 로고    scopus 로고
    • Dovitinib preferentially targets endothelial cells rather than cancer cells for the inhibition of hepatocellular carcinoma growth and metastasis
    • Chen ZY, Shi M, Peng LX, Wei W, Li XJ, Guo ZX, et al. (2012). Dovitinib preferentially targets endothelial cells rather than cancer cells for the inhibition of hepatocellular carcinoma growth and metastasis. J Transl Med 10: 245.
    • (2012) J Transl Med , vol.10 , pp. 245
    • Chen, Z.Y.1    Shi, M.2    Peng, L.X.3    Wei, W.4    Li, X.J.5    Guo, Z.X.6
  • 39
    • 84871384069 scopus 로고    scopus 로고
    • Metastatic pancreatic cancer: Are we making progress in treatment?
    • Chiu J, Yau T, (2012). Metastatic pancreatic cancer: are we making progress in treatment? Gastroenterol Res Pract 2012: 898931.
    • (2012) Gastroenterol Res Pract , vol.2012 , pp. 898931
    • Chiu, J.1    Yau, T.2
  • 40
    • 77953988924 scopus 로고    scopus 로고
    • Targeting the tumour vasculature: Insights from physiological angiogenesis
    • Chung AS, Lee J, Ferrara N, (2010). Targeting the tumour vasculature: insights from physiological angiogenesis. Nat Rev Cancer 10: 505-514.
    • (2010) Nat Rev Cancer , vol.10 , pp. 505-514
    • Chung, A.S.1    Lee, J.2    Ferrara, N.3
  • 41
    • 84857640591 scopus 로고    scopus 로고
    • Cancer associated fibroblasts: The dark side of the coin
    • Cirri P, Chiarugi P, (2011). Cancer associated fibroblasts: the dark side of the coin. Am J Cancer Res 1: 482-497.
    • (2011) Am J Cancer Res , vol.1 , pp. 482-497
    • Cirri, P.1    Chiarugi, P.2
  • 42
    • 34147190880 scopus 로고    scopus 로고
    • FDA drug approval summary: Bevacizumab plus FOLFOX4 as second-line treatment of colorectal cancer
    • Cohen MH, Gootenberg J, Keegan P, Pazdur R, (2007). FDA drug approval summary: bevacizumab plus FOLFOX4 as second-line treatment of colorectal cancer. Oncologist 12: 356-361.
    • (2007) Oncologist , vol.12 , pp. 356-361
    • Cohen, M.H.1    Gootenberg, J.2    Keegan, P.3    Pazdur, R.4
  • 43
    • 0036682484 scopus 로고    scopus 로고
    • A monoclonal antibody to vascular endothelial-cadherin inhibits tumor angiogenesis without side effects on endothelial permeability
    • Corada M, Zanetta L, Orsenigo F, Breviario F, Lampugnani MG, Bernasconi S, et al. (2002). A monoclonal antibody to vascular endothelial-cadherin inhibits tumor angiogenesis without side effects on endothelial permeability. Blood 100: 905-911.
    • (2002) Blood , vol.100 , pp. 905-911
    • Corada, M.1    Zanetta, L.2    Orsenigo, F.3    Breviario, F.4    Lampugnani, M.G.5    Bernasconi, S.6
  • 44
    • 78650051896 scopus 로고    scopus 로고
    • Zoledronic acid repolarizes tumour-associated macrophages and inhibits mammary carcinogenesis by targeting the mevalonate pathway
    • Coscia M, Quaglino E, Iezzi M, Curcio C, Pantaleoni F, Riganti C, et al. (2010). Zoledronic acid repolarizes tumour-associated macrophages and inhibits mammary carcinogenesis by targeting the mevalonate pathway. J Cell Mol Med 14: 2803-2815.
    • (2010) J Cell Mol Med , vol.14 , pp. 2803-2815
    • Coscia, M.1    Quaglino, E.2    Iezzi, M.3    Curcio, C.4    Pantaleoni, F.5    Riganti, C.6
  • 45
    • 0037192458 scopus 로고    scopus 로고
    • Matrix metalloproteinase inhibitors and cancer: Trials and tribulations
    • Coussens LM, Fingleton B, Matrisian LM, (2002). Matrix metalloproteinase inhibitors and cancer: trials and tribulations. Science 295: 2387-2392.
    • (2002) Science , vol.295 , pp. 2387-2392
    • Coussens, L.M.1    Fingleton, B.2    Matrisian, L.M.3
  • 46
    • 57849106330 scopus 로고    scopus 로고
    • PDGF-C mediates the angiogenic and tumorigenic properties of fibroblasts associated with tumors refractory to anti-VEGF treatment
    • Crawford Y, Kasman I, Yu L, Zhong C, Wu X, Modrusan Z, et al. (2009). PDGF-C mediates the angiogenic and tumorigenic properties of fibroblasts associated with tumors refractory to anti-VEGF treatment. Cancer Cell 15: 21-34.
    • (2009) Cancer Cell , vol.15 , pp. 21-34
    • Crawford, Y.1    Kasman, I.2    Yu, L.3    Zhong, C.4    Wu, X.5    Modrusan, Z.6
  • 48
    • 60649108677 scopus 로고    scopus 로고
    • Selective inhibition of matrix metalloproteinase-14 blocks tumor growth, invasion, and angiogenesis
    • Devy L, Huang L, Naa L, Yanamandra N, Pieters H, Frans N, et al. (2009). Selective inhibition of matrix metalloproteinase-14 blocks tumor growth, invasion, and angiogenesis. Cancer Res 69: 1517-1526.
    • (2009) Cancer Res , vol.69 , pp. 1517-1526
    • Devy, L.1    Huang, L.2    Naa, L.3    Yanamandra, N.4    Pieters, H.5    Frans, N.6
  • 49
    • 79951676056 scopus 로고    scopus 로고
    • PG545, a dual heparanase and angiogenesis inhibitor, induces potent anti-tumour and anti-metastatic efficacy in preclinical models
    • Dredge K, Hammond E, Handley P, Gonda TJ, Smith MT, Vincent C, et al. (2011). PG545, a dual heparanase and angiogenesis inhibitor, induces potent anti-tumour and anti-metastatic efficacy in preclinical models. Br J Cancer 104: 635-642.
    • (2011) Br J Cancer , vol.104 , pp. 635-642
    • Dredge, K.1    Hammond, E.2    Handley, P.3    Gonda, T.J.4    Smith, M.T.5    Vincent, C.6
  • 50
    • 3242678017 scopus 로고    scopus 로고
    • Antiangiogenic potency of various chemotherapeutic drugs for metronomic chemotherapy
    • Drevs J, Fakler J, Eisele S, Medinger M, Bing G, Esser N, et al. (2004). Antiangiogenic potency of various chemotherapeutic drugs for metronomic chemotherapy. Anticancer Res 24: 1759-1763.
    • (2004) Anticancer Res , vol.24 , pp. 1759-1763
    • Drevs, J.1    Fakler, J.2    Eisele, S.3    Medinger, M.4    Bing, G.5    Esser, N.6
  • 53
    • 42349084306 scopus 로고    scopus 로고
    • NVP-AUY922: A novel heat shock protein 90 inhibitor active against xenograft tumor growth, angiogenesis, and metastasis
    • Eccles SA, Massey A, Raynaud FI, Sharp SY, Box G, Valenti M, et al. (2008). NVP-AUY922: a novel heat shock protein 90 inhibitor active against xenograft tumor growth, angiogenesis, and metastasis. Cancer Res 68: 2850-2860.
    • (2008) Cancer Res , vol.68 , pp. 2850-2860
    • Eccles, S.A.1    Massey, A.2    Raynaud, F.I.3    Sharp, S.Y.4    Box, G.5    Valenti, M.6
  • 54
    • 54449094358 scopus 로고    scopus 로고
    • Identification of amino acids essential for the antiangiogenic activity of tumstatin and its use in combination antitumor activity
    • Eikesdal HP, Sugimoto H, Birrane G, Maeshima Y, Cooke VG, Kieran M, et al. (2008). Identification of amino acids essential for the antiangiogenic activity of tumstatin and its use in combination antitumor activity. Proc Natl Acad Sci U S A 105: 15040-15045.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 15040-15045
    • Eikesdal, H.P.1    Sugimoto, H.2    Birrane, G.3    Maeshima, Y.4    Cooke, V.G.5    Kieran, M.6
  • 55
    • 77955476115 scopus 로고    scopus 로고
    • Bleeding complications of antiangiogenic therapy: Pathogenetic mechanisms and clinical impact
    • Elice F, Rodeghiero F, (2010). Bleeding complications of antiangiogenic therapy: pathogenetic mechanisms and clinical impact. Thromb Res 125 (Suppl. 2): S55-S57.
    • (2010) Thromb Res , vol.125 , Issue.SUPPL. 2
    • Elice, F.1    Rodeghiero, F.2
  • 56
    • 84862154963 scopus 로고    scopus 로고
    • Side effects of anti-angiogenic drugs
    • Elice F, Rodeghiero F, (2012). Side effects of anti-angiogenic drugs. Thromb Res 129 (Suppl. 1): S50-S53.
    • (2012) Thromb Res , vol.129 , Issue.SUPPL. 1
    • Elice, F.1    Rodeghiero, F.2
  • 57
    • 47949089077 scopus 로고    scopus 로고
    • VEGF-targeted therapy: Mechanisms of anti-tumour activity
    • Ellis LM, Hicklin DJ, (2008). VEGF-targeted therapy: mechanisms of anti-tumour activity. Nat Rev Cancer 8: 579-591.
    • (2008) Nat Rev Cancer , vol.8 , pp. 579-591
    • Ellis, L.M.1    Hicklin, D.J.2
  • 58
    • 34547788817 scopus 로고    scopus 로고
    • Peroxynitrite mediates VEGF's angiogenic signal and function via a nitration-independent mechanism in endothelial cells
    • El-Remessy AB, Al-Shabrawey M, Platt DH, Bartoli M, Behzadian MA, Ghaly N, et al. (2007). Peroxynitrite mediates VEGF's angiogenic signal and function via a nitration-independent mechanism in endothelial cells. FASEB J 21: 2528-2539.
    • (2007) FASEB J , vol.21 , pp. 2528-2539
    • El-Remessy, A.B.1    Al-Shabrawey, M.2    Platt, D.H.3    Bartoli, M.4    Behzadian, M.A.5    Ghaly, N.6
  • 59
    • 44949142600 scopus 로고    scopus 로고
    • Final results from cohort 1 of a phase II study of volociximab, an anti-{alpha}5{beta}1 integrin antibody, in combination with gemcitabine (GEM) in patients (pts) with metastatic pancreatic cancer (MPC)
    • Evans T, Ramanathan RK, Yazji S, Glynne-Jones R, Anthoney A, Berlin J, et al. (2007). Final results from cohort 1 of a phase II study of volociximab, an anti-{alpha}5{beta}1 integrin antibody, in combination with gemcitabine (GEM) in patients (pts) with metastatic pancreatic cancer (MPC). ASCO Meeting Abstracts 25 (18 Suppl.): 4549.
    • (2007) ASCO Meeting Abstracts , vol.25 , Issue.18 SUPPL. , pp. 4549
    • Evans, T.1    Ramanathan, R.K.2    Yazji, S.3    Glynne-Jones, R.4    Anthoney, A.5    Berlin, J.6
  • 60
    • 84867593323 scopus 로고    scopus 로고
    • Maintenance bevacizumab beyond first-line paclitaxel plus bevacizumab in patients with Her2-negative hormone receptor-positive metastatic breast cancer: Efficacy in combination with hormonal therapy
    • Fabi A, Russillo M, Ferretti G, Metro G, Nistico C, Papaldo P, et al. (2012). Maintenance bevacizumab beyond first-line paclitaxel plus bevacizumab in patients with Her2-negative hormone receptor-positive metastatic breast cancer: efficacy in combination with hormonal therapy. BMC Cancer 12: 482.
    • (2012) BMC Cancer , vol.12 , pp. 482
    • Fabi, A.1    Russillo, M.2    Ferretti, G.3    Metro, G.4    Nistico, C.5    Papaldo, P.6
  • 61
    • 84868486023 scopus 로고    scopus 로고
    • Angiopoietins in angiogenesis
    • Fagiani E, Christofori G, (2013). Angiopoietins in angiogenesis. Cancer Lett 328: 18-26.
    • (2013) Cancer Lett , vol.328 , pp. 18-26
    • Fagiani, E.1    Christofori, G.2
  • 62
    • 84871294854 scopus 로고    scopus 로고
    • Efficacy and safety of bevacizumab for the treatment of advanced hepatocellular carcinoma: A systematic review of phase II trials
    • Fang P, Hu JH, Cheng ZG, Liu ZF, Wang JL, Jiao SC, (2012). Efficacy and safety of bevacizumab for the treatment of advanced hepatocellular carcinoma: a systematic review of phase II trials. PLoS One 7: e49717.
    • (2012) PLoS One , vol.7
    • Fang, P.1    Hu, J.H.2    Cheng, Z.G.3    Liu, Z.F.4    Wang, J.L.5    Jiao, S.C.6
  • 63
    • 30744449235 scopus 로고    scopus 로고
    • Angiogenesis as a therapeutic target
    • Ferrara N, Kerbel RS, (2005). Angiogenesis as a therapeutic target. Nature 438: 967-974.
    • (2005) Nature , vol.438 , pp. 967-974
    • Ferrara, N.1    Kerbel, R.S.2
  • 64
    • 33845351712 scopus 로고    scopus 로고
    • Phase II study of volociximab (M200), an {alpha}5{beta}1 anti-integrin antibody in refractory metastatic clear cell renal cell cancer (RCC)
    • Figlin RA, Kondagunta GV, Yazji S, Motzer RJ, Bukowski RM, (2006). Phase II study of volociximab (M200), an {alpha}5{beta}1 anti-integrin antibody in refractory metastatic clear cell renal cell cancer (RCC). ASCO Meeting Abstracts 24 (18 Suppl.): 4535.
    • (2006) ASCO Meeting Abstracts , vol.24 , Issue.18 SUPPL. , pp. 4535
    • Figlin, R.A.1    Kondagunta, G.V.2    Yazji, S.3    Motzer, R.J.4    Bukowski, R.M.5
  • 65
    • 85013312416 scopus 로고
    • Tumor angiogenesis: Therapeutic implications
    • Folkman J, (1971). Tumor angiogenesis: therapeutic implications. N Engl J Med 285: 1182-1186.
    • (1971) N Engl J Med , vol.285 , pp. 1182-1186
    • Folkman, J.1
  • 66
    • 0028929803 scopus 로고
    • Angiogenesis in cancer, vascular, rheumatoid and other disease
    • Folkman J, (1995). Angiogenesis in cancer, vascular, rheumatoid and other disease. Nat Med 1: 27-30.
    • (1995) Nat Med , vol.1 , pp. 27-30
    • Folkman, J.1
  • 67
    • 0037376877 scopus 로고    scopus 로고
    • Angiogenesis and apoptosis
    • Folkman J, (2003). Angiogenesis and apoptosis. Semin Cancer Biol 13: 159-167.
    • (2003) Semin Cancer Biol , vol.13 , pp. 159-167
    • Folkman, J.1
  • 68
    • 33947732977 scopus 로고    scopus 로고
    • Angiogenesis: An organizing principle for drug discovery?
    • Folkman J, (2007). Angiogenesis: an organizing principle for drug discovery? Nat Rev Drug Discov 6: 273-286.
    • (2007) Nat Rev Drug Discov , vol.6 , pp. 273-286
    • Folkman, J.1
  • 69
    • 77952189779 scopus 로고    scopus 로고
    • Metronomic cyclophosphamide in elderly patients with advanced, castration-resistant prostate cancer
    • Fontana A, Bocci G, Galli L, D'Arcangelo M, Derosa L, Fioravanti A, et al. (2010). Metronomic cyclophosphamide in elderly patients with advanced, castration-resistant prostate cancer. J Am Geriatr Soc 58: 986-988.
    • (2010) J Am Geriatr Soc , vol.58 , pp. 986-988
    • Fontana, A.1    Bocci, G.2    Galli, L.3    D'Arcangelo, M.4    Derosa, L.5    Fioravanti, A.6
  • 70
    • 0037112368 scopus 로고    scopus 로고
    • Bisphosphonates inhibit angiogenesis in vitro and testosterone-stimulated vascular regrowth in the ventral prostate in castrated rats
    • Fournier P, Boissier S, Filleur S, Guglielmi J, Cabon F, Colombel M, et al. (2002). Bisphosphonates inhibit angiogenesis in vitro and testosterone-stimulated vascular regrowth in the ventral prostate in castrated rats. Cancer Res 62: 6538-6544.
    • (2002) Cancer Res , vol.62 , pp. 6538-6544
    • Fournier, P.1    Boissier, S.2    Filleur, S.3    Guglielmi, J.4    Cabon, F.5    Colombel, M.6
  • 71
    • 33645735004 scopus 로고    scopus 로고
    • Targeted anti-vascular endothelial growth factor receptor-2 therapy leads to short-term and long-term impairment of vascular function and increase in tumor hypoxia
    • Franco M, Man S, Chen L, Emmenegger U, Shaked Y, Cheung AM, et al. (2006). Targeted anti-vascular endothelial growth factor receptor-2 therapy leads to short-term and long-term impairment of vascular function and increase in tumor hypoxia. Cancer Res 66: 3639-3648.
    • (2006) Cancer Res , vol.66 , pp. 3639-3648
    • Franco, M.1    Man, S.2    Chen, L.3    Emmenegger, U.4    Shaked, Y.5    Cheung, A.M.6
  • 72
    • 34447554872 scopus 로고    scopus 로고
    • Inhibition of laminin-8 in vivo using a novel poly(malic acid)-based carrier reduces glioma angiogenesis
    • Fujita M, Khazenzon NM, Ljubimov AV, Lee BS, Virtanen I, Holler E, et al. (2006). Inhibition of laminin-8 in vivo using a novel poly(malic acid)-based carrier reduces glioma angiogenesis. Angiogenesis 9: 183-191.
    • (2006) Angiogenesis , vol.9 , pp. 183-191
    • Fujita, M.1    Khazenzon, N.M.2    Ljubimov, A.V.3    Lee, B.S.4    Virtanen, I.5    Holler, E.6
  • 73
    • 10744223595 scopus 로고    scopus 로고
    • The combination of the tyrosine kinase receptor inhibitor SU6668 with paclitaxel affects ascites formation and tumor spread in ovarian carcinoma xenografts growing orthotopically
    • Garofalo A, Naumova E, Manenti L, Ghilardi C, Ghisleni G, Caniatti M, et al. (2003). The combination of the tyrosine kinase receptor inhibitor SU6668 with paclitaxel affects ascites formation and tumor spread in ovarian carcinoma xenografts growing orthotopically. Clin Cancer Res 9: 3476-3485.
    • (2003) Clin Cancer Res , vol.9 , pp. 3476-3485
    • Garofalo, A.1    Naumova, E.2    Manenti, L.3    Ghilardi, C.4    Ghisleni, G.5    Caniatti, M.6
  • 74
    • 84860120185 scopus 로고    scopus 로고
    • AZD4547: An orally bioavailable, potent, and selective inhibitor of the fibroblast growth factor receptor tyrosine kinase family
    • Gavine PR, Mooney L, Kilgour E, Thomas AP, Al-Kadhimi K, Beck S, et al. (2012). AZD4547: an orally bioavailable, potent, and selective inhibitor of the fibroblast growth factor receptor tyrosine kinase family. Cancer Res 72: 2045-2056.
    • (2012) Cancer Res , vol.72 , pp. 2045-2056
    • Gavine, P.R.1    Mooney, L.2    Kilgour, E.3    Thomas, A.P.4    Al-Kadhimi, K.5    Beck, S.6
  • 75
    • 84861190138 scopus 로고    scopus 로고
    • A preclinical and clinical review of aflibercept for the management of cancer
    • Gaya A, Tse V, (2012). A preclinical and clinical review of aflibercept for the management of cancer. Cancer Treat Rev 38: 484-493.
    • (2012) Cancer Treat Rev , vol.38 , pp. 484-493
    • Gaya, A.1    Tse, V.2
  • 76
    • 84856933036 scopus 로고    scopus 로고
    • Oral metronomic cyclophosphamide with and without methotrexate as palliative treatment for patients with metastatic breast carcinoma
    • Gebbia V, Boussen H, Valerio MR, (2012). Oral metronomic cyclophosphamide with and without methotrexate as palliative treatment for patients with metastatic breast carcinoma. Anticancer Res 32: 529-536.
    • (2012) Anticancer Res , vol.32 , pp. 529-536
    • Gebbia, V.1    Boussen, H.2    Valerio, M.R.3
  • 78
    • 77956280130 scopus 로고    scopus 로고
    • Reciprocal activation of prostate cancer cells and cancer-associated fibroblasts stimulates epithelial-mesenchymal transition and cancer stemness
    • Giannoni E, Bianchini F, Masieri L, Serni S, Torre E, Calorini L, et al. (2010). Reciprocal activation of prostate cancer cells and cancer-associated fibroblasts stimulates epithelial-mesenchymal transition and cancer stemness. Cancer Res 70: 6945-6956.
    • (2010) Cancer Res , vol.70 , pp. 6945-6956
    • Giannoni, E.1    Bianchini, F.2    Masieri, L.3    Serni, S.4    Torre, E.5    Calorini, L.6
  • 79
    • 33748752619 scopus 로고    scopus 로고
    • A phase II study of high-dose bevacizumab in combination with irinotecan, 5-fluorouracil, leucovorin, as initial therapy for advanced colorectal cancer: Results from the Eastern Cooperative Oncology Group study E2200
    • Giantonio BJ, Levy DE, O'Dwyer PJ, Meropol NJ, Catalano PJ, Benson AB, 3rd, (2006). A phase II study of high-dose bevacizumab in combination with irinotecan, 5-fluorouracil, leucovorin, as initial therapy for advanced colorectal cancer: results from the Eastern Cooperative Oncology Group study E2200. Ann Oncol 17: 1399-1403.
    • (2006) Ann Oncol , vol.17 , pp. 1399-1403
    • Giantonio, B.J.1    Levy, D.E.2    O'Dwyer, P.J.3    Meropol, N.J.4    Catalano, P.J.5    Benson III, A.B.6
  • 80
    • 34248173883 scopus 로고    scopus 로고
    • Bevacizumab in combination with oxaliplatin, fluorouracil, and leucovorin (FOLFOX4) for previously treated metastatic colorectal cancer: Results from the Eastern Cooperative Oncology Group Study E3200
    • Giantonio BJ, Catalano PJ, Meropol NJ, O'Dwyer PJ, Mitchell EP, Alberts SR, et al. (2007). Bevacizumab in combination with oxaliplatin, fluorouracil, and leucovorin (FOLFOX4) for previously treated metastatic colorectal cancer: results from the Eastern Cooperative Oncology Group Study E3200. J Clin Oncol 25: 1539-1544.
    • (2007) J Clin Oncol , vol.25 , pp. 1539-1544
    • Giantonio, B.J.1    Catalano, P.J.2    Meropol, N.J.3    O'Dwyer, P.J.4    Mitchell, E.P.5    Alberts, S.R.6
  • 81
    • 4944239035 scopus 로고    scopus 로고
    • An amino-bisphosphonate targets MMP-9-expressing macrophages and angiogenesis to impair cervical carcinogenesis
    • Giraudo E, Inoue M, Hanahan D, (2004). An amino-bisphosphonate targets MMP-9-expressing macrophages and angiogenesis to impair cervical carcinogenesis. J Clin Invest 114: 623-633.
    • (2004) J Clin Invest , vol.114 , pp. 623-633
    • Giraudo, E.1    Inoue, M.2    Hanahan, D.3
  • 83
    • 0033564974 scopus 로고    scopus 로고
    • Blockage of the vascular endothelial growth factor stress response increases the antitumor effects of ionizing radiation
    • Gorski DH, Beckett MA, Jaskowiak NT, Calvin DP, Mauceri HJ, Salloum RM, et al. (1999). Blockage of the vascular endothelial growth factor stress response increases the antitumor effects of ionizing radiation. Cancer Res 59: 3374-3378.
    • (1999) Cancer Res , vol.59 , pp. 3374-3378
    • Gorski, D.H.1    Beckett, M.A.2    Jaskowiak, N.T.3    Calvin, D.P.4    Mauceri, H.J.5    Salloum, R.M.6
  • 84
    • 84859402751 scopus 로고    scopus 로고
    • Ponatinib (AP24534), a multitargeted pan-FGFR inhibitor with activity in multiple FGFR-amplified or mutated cancer models
    • Gozgit JM, Wong MJ, Moran L, Wardwell S, Mohemmad QK, Narasimhan NI, et al. (2012). Ponatinib (AP24534), a multitargeted pan-FGFR inhibitor with activity in multiple FGFR-amplified or mutated cancer models. Mol Cancer Ther 11: 690-699.
    • (2012) Mol Cancer Ther , vol.11 , pp. 690-699
    • Gozgit, J.M.1    Wong, M.J.2    Moran, L.3    Wardwell, S.4    Mohemmad, Q.K.5    Narasimhan, N.I.6
  • 85
    • 1642368865 scopus 로고    scopus 로고
    • Thrombospondin-1 associated with tumor microenvironment contributes to low-dose cyclophosphamide-mediated endothelial cell apoptosis and tumor growth suppression
    • Hamano Y, Sugimoto H, Soubasakos MA, Kieran M, Olsen BR, Lawler J, et al. (2004). Thrombospondin-1 associated with tumor microenvironment contributes to low-dose cyclophosphamide-mediated endothelial cell apoptosis and tumor growth suppression. Cancer Res 64: 1570-1574.
    • (2004) Cancer Res , vol.64 , pp. 1570-1574
    • Hamano, Y.1    Sugimoto, H.2    Soubasakos, M.A.3    Kieran, M.4    Olsen, B.R.5    Lawler, J.6
  • 86
    • 24744467401 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1alpha and antiangiogenic activity of farnesyltransferase inhibitor SCH66336 in human aerodigestive tract cancer
    • Han JY, Oh SH, Morgillo F, Myers JN, Kim E, Hong WK, et al. (2005). Hypoxia-inducible factor 1alpha and antiangiogenic activity of farnesyltransferase inhibitor SCH66336 in human aerodigestive tract cancer. J Natl Cancer Inst 97: 1272-1286.
    • (2005) J Natl Cancer Inst , vol.97 , pp. 1272-1286
    • Han, J.Y.1    Oh, S.H.2    Morgillo, F.3    Myers, J.N.4    Kim, E.5    Hong, W.K.6
  • 87
    • 33749003219 scopus 로고    scopus 로고
    • Antiangiogenic and antitumor effects of SRC inhibition in ovarian carcinoma
    • Han LY, Landen CN, Trevino JG, Halder J, Lin YG, Kamat AA, et al. (2006). Antiangiogenic and antitumor effects of SRC inhibition in ovarian carcinoma. Cancer Res 66: 8633-8639.
    • (2006) Cancer Res , vol.66 , pp. 8633-8639
    • Han, L.Y.1    Landen, C.N.2    Trevino, J.G.3    Halder, J.4    Lin, Y.G.5    Kamat, A.A.6
  • 88
    • 0030576517 scopus 로고    scopus 로고
    • Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis
    • Hanahan D, Folkman J, (1996). Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. Cell 86: 353-364.
    • (1996) Cell , vol.86 , pp. 353-364
    • Hanahan, D.1    Folkman, J.2
  • 89
    • 34548175694 scopus 로고    scopus 로고
    • Assessment of the biological and pharmacological effects of the alpha nu beta3 and alpha nu beta5 integrin receptor antagonist, cilengitide (EMD 121974), in patients with advanced solid tumors
    • Hariharan S, Gustafson D, Holden S, McConkey D, Davis D, Morrow M, et al. (2007). Assessment of the biological and pharmacological effects of the alpha nu beta3 and alpha nu beta5 integrin receptor antagonist, cilengitide (EMD 121974), in patients with advanced solid tumors. Ann Oncol 18: 1400-1407.
    • (2007) Ann Oncol , vol.18 , pp. 1400-1407
    • Hariharan, S.1    Gustafson, D.2    Holden, S.3    McConkey, D.4    Davis, D.5    Morrow, M.6
  • 90
    • 77950491674 scopus 로고    scopus 로고
    • Phase I/II study of the Src inhibitor dasatinib in combination with erlotinib in advanced non-small-cell lung cancer
    • Haura EB, Tanvetyanon T, Chiappori A, Williams C, Simon G, Antonia S, et al. (2010). Phase I/II study of the Src inhibitor dasatinib in combination with erlotinib in advanced non-small-cell lung cancer. J Clin Oncol 28: 1387-1394.
    • (2010) J Clin Oncol , vol.28 , pp. 1387-1394
    • Haura, E.B.1    Tanvetyanon, T.2    Chiappori, A.3    Williams, C.4    Simon, G.5    Antonia, S.6
  • 91
    • 84876401041 scopus 로고    scopus 로고
    • Molecular mechanism of SSR128129E, an extracellularly acting, small-molecule, allosteric inhibitor of FGF receptor signaling
    • Herbert C, Schieborr U, Saxena K, Juraszek J, De Smet F, Alcouffe C, et al. (2013). Molecular mechanism of SSR128129E, an extracellularly acting, small-molecule, allosteric inhibitor of FGF receptor signaling. Cancer Cell 23: 489-501.
    • (2013) Cancer Cell , vol.23 , pp. 489-501
    • Herbert, C.1    Schieborr, U.2    Saxena, K.3    Juraszek, J.4    De Smet, F.5    Alcouffe, C.6
  • 92
    • 14644440555 scopus 로고    scopus 로고
    • Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis
    • Hicklin DJ, Ellis LM, (2005). Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis. J Clin Oncol 23: 1011-1027.
    • (2005) J Clin Oncol , vol.23 , pp. 1011-1027
    • Hicklin, D.J.1    Ellis, L.M.2
  • 93
    • 49649123154 scopus 로고    scopus 로고
    • BIBF 1120: Triple angiokinase inhibitor with sustained receptor blockade and good antitumor efficacy
    • Hilberg F, Roth GJ, Krssak M, Kautschitsch S, Sommergruber W, Tontsch-Grunt U, et al. (2008). BIBF 1120: triple angiokinase inhibitor with sustained receptor blockade and good antitumor efficacy. Cancer Res 68: 4774-4782.
    • (2008) Cancer Res , vol.68 , pp. 4774-4782
    • Hilberg, F.1    Roth, G.J.2    Krssak, M.3    Kautschitsch, S.4    Sommergruber, W.5    Tontsch-Grunt, U.6
  • 94
    • 36148937125 scopus 로고    scopus 로고
    • Tumour vascularization: Sprouting angiogenesis and beyond
    • Hillen F, Griffioen AW, (2007). Tumour vascularization: sprouting angiogenesis and beyond. Cancer Metastasis Rev 26: 489-502.
    • (2007) Cancer Metastasis Rev , vol.26 , pp. 489-502
    • Hillen, F.1    Griffioen, A.W.2
  • 95
    • 42349114587 scopus 로고    scopus 로고
    • Endothelial sprouting and angiogenesis: Matrix metalloproteinases in the lead
    • van Hinsbergh VW, Koolwijk P, (2008). Endothelial sprouting and angiogenesis: matrix metalloproteinases in the lead. Cardiovasc Res 78: 203-212.
    • (2008) Cardiovasc Res , vol.78 , pp. 203-212
    • Van Hinsbergh, V.W.1    Koolwijk, P.2
  • 96
    • 0033580889 scopus 로고    scopus 로고
    • Vessel cooption, regression, and growth in tumors mediated by angiopoietins and VEGF
    • Holash J, Maisonpierre PC, Compton D, Boland P, Alexander CR, Zagzag D, et al. (1999). Vessel cooption, regression, and growth in tumors mediated by angiopoietins and VEGF. Science 284: 1994-1998.
    • (1999) Science , vol.284 , pp. 1994-1998
    • Holash, J.1    Maisonpierre, P.C.2    Compton, D.3    Boland, P.4    Alexander, C.R.5    Zagzag, D.6
  • 97
    • 23844544081 scopus 로고    scopus 로고
    • Clinical evaluation of ZD6474, an orally active inhibitor of VEGF and EGF receptor signaling, in patients with solid, malignant tumors
    • Holden SN, Eckhardt SG, Basser R, de Boer R, Rischin D, Green M, et al. (2005). Clinical evaluation of ZD6474, an orally active inhibitor of VEGF and EGF receptor signaling, in patients with solid, malignant tumors. Ann Oncol 16: 1391-1397.
    • (2005) Ann Oncol , vol.16 , pp. 1391-1397
    • Holden, S.N.1    Eckhardt, S.G.2    Basser, R.3    De Boer, R.4    Rischin, D.5    Green, M.6
  • 98
    • 0027064888 scopus 로고
    • Dual regulation of vascular endothelial growth factor bioavailability by genetic and proteolytic mechanisms
    • Houck KA, Leung DW, Rowland AM, Winer J, Ferrara N, (1992). Dual regulation of vascular endothelial growth factor bioavailability by genetic and proteolytic mechanisms. J Biol Chem 267: 26031-26037.
    • (1992) J Biol Chem , vol.267 , pp. 26031-26037
    • Houck, K.A.1    Leung, D.W.2    Rowland, A.M.3    Winer, J.4    Ferrara, N.5
  • 99
    • 84862832278 scopus 로고    scopus 로고
    • Vandetanib in patients with inoperable hepatocellular carcinoma: A phase II, randomized, double-blind, placebo-controlled study
    • Hsu C, Yang TS, Huo TI, Hsieh RK, Yu CW, Hwang WS, et al. (2012). Vandetanib in patients with inoperable hepatocellular carcinoma: a phase II, randomized, double-blind, placebo-controlled study. J Hepatol 56: 1097-1103.
    • (2012) J Hepatol , vol.56 , pp. 1097-1103
    • Hsu, C.1    Yang, T.S.2    Huo, T.I.3    Hsieh, R.K.4    Yu, C.W.5    Hwang, W.S.6
  • 100
    • 70349277438 scopus 로고    scopus 로고
    • Monoclonal antibodies targeting vascular endothelial growth factor: Current status and future challenges in cancer therapy
    • Hsu JY, Wakelee HA, (2009). Monoclonal antibodies targeting vascular endothelial growth factor: current status and future challenges in cancer therapy. BioDrugs 23: 289-304.
    • (2009) BioDrugs , vol.23 , pp. 289-304
    • Hsu, J.Y.1    Wakelee, H.A.2
  • 101
    • 76249126867 scopus 로고    scopus 로고
    • Sunitinib acts primarily on tumor endothelium rather than tumor cells to inhibit the growth of renal cell carcinoma
    • Huang D, Ding Y, Li Y, Luo W-M, Zhang Z-F, Snider J, et al. (2010). Sunitinib acts primarily on tumor endothelium rather than tumor cells to inhibit the growth of renal cell carcinoma. Cancer Res 70: 1053-1062.
    • (2010) Cancer Res , vol.70 , pp. 1053-1062
    • Huang, D.1    Ding, Y.2    Li, Y.3    Luo, W.-M.4    Zhang, Z.-F.5    Snider, J.6
  • 102
    • 2542561964 scopus 로고    scopus 로고
    • Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer
    • Hurwitz H, Fehrenbacher L, Novotny W, Cartwright T, Hainsworth J, Heim W, et al. (2004). Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N Engl J Med 350: 2335-2342.
    • (2004) N Engl J Med , vol.350 , pp. 2335-2342
    • Hurwitz, H.1    Fehrenbacher, L.2    Novotny, W.3    Cartwright, T.4    Hainsworth, J.5    Heim, W.6
  • 103
  • 104
    • 80053405625 scopus 로고    scopus 로고
    • Inhibiting Cxcr2 disrupts tumor-stromal interactions and improves survival in a mouse model of pancreatic ductal adenocarcinoma
    • Ijichi H, Chytil A, Gorska AE, Aakre ME, Bierie B, Tada M, et al. (2011). Inhibiting Cxcr2 disrupts tumor-stromal interactions and improves survival in a mouse model of pancreatic ductal adenocarcinoma. J Clin Invest 121: 4106-4117.
    • (2011) J Clin Invest , vol.121 , pp. 4106-4117
    • Ijichi, H.1    Chytil, A.2    Gorska, A.E.3    Aakre, M.E.4    Bierie, B.5    Tada, M.6
  • 105
    • 70349782389 scopus 로고    scopus 로고
    • An overview of small-molecule inhibitors of VEGFR signaling
    • Ivy SP, Wick JY, Kaufman BM, (2009). An overview of small-molecule inhibitors of VEGFR signaling. Nat Rev Clin Oncol 6: 569-579.
    • (2009) Nat Rev Clin Oncol , vol.6 , pp. 569-579
    • Ivy, S.P.1    Wick, J.Y.2    Kaufman, B.M.3
  • 106
    • 23344433262 scopus 로고    scopus 로고
    • Biomarkers of anticancer activity of R115777 (Tipifarnib, Zarnestra) in human breast cancer models in vitro
    • Izbicka E, Campos D, Carrizales G, Patnaik A, (2005). Biomarkers of anticancer activity of R115777 (Tipifarnib, Zarnestra) in human breast cancer models in vitro. Anticancer Res 25: 3215-3223.
    • (2005) Anticancer Res , vol.25 , pp. 3215-3223
    • Izbicka, E.1    Campos, D.2    Carrizales, G.3    Patnaik, A.4
  • 108
    • 0034796595 scopus 로고    scopus 로고
    • Normalizing tumor vasculature with anti-angiogenic therapy: A new paradigm for combination therapy
    • Jain RK, (2001). Normalizing tumor vasculature with anti-angiogenic therapy: a new paradigm for combination therapy. Nat Med 7: 987-989.
    • (2001) Nat Med , vol.7 , pp. 987-989
    • Jain, R.K.1
  • 109
    • 0038376002 scopus 로고    scopus 로고
    • Molecular regulation of vessel maturation
    • Jain RK, (2003). Molecular regulation of vessel maturation. Nat Med 9: 685-693.
    • (2003) Nat Med , vol.9 , pp. 685-693
    • Jain, R.K.1
  • 110
    • 11844254414 scopus 로고    scopus 로고
    • Normalization of tumor vasculature: An emerging concept in antiangiogenic therapy
    • Jain RK, (2005). Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy. Science 307: 58-62.
    • (2005) Science , vol.307 , pp. 58-62
    • Jain, R.K.1
  • 112
    • 0037192635 scopus 로고    scopus 로고
    • Complex roles of tissue inhibitors of metalloproteinases in cancer
    • Jiang Y, Goldberg ID, Shi YE, (2002). Complex roles of tissue inhibitors of metalloproteinases in cancer. Oncogene 21: 2245-2252.
    • (2002) Oncogene , vol.21 , pp. 2245-2252
    • Jiang, Y.1    Goldberg, I.D.2    Shi, Y.E.3
  • 113
    • 2942657615 scopus 로고    scopus 로고
    • Randomized phase II trial comparing bevacizumab plus carboplatin and paclitaxel with carboplatin and paclitaxel alone in previously untreated locally advanced or metastatic non-small-cell lung cancer
    • Johnson DH, Fehrenbacher L, Novotny WF, Herbst RS, Nemunaitis JJ, Jablons DM, et al. (2004). Randomized phase II trial comparing bevacizumab plus carboplatin and paclitaxel with carboplatin and paclitaxel alone in previously untreated locally advanced or metastatic non-small-cell lung cancer. J Clin Oncol 22: 2184-2191.
    • (2004) J Clin Oncol , vol.22 , pp. 2184-2191
    • Johnson, D.H.1    Fehrenbacher, L.2    Novotny, W.F.3    Herbst, R.S.4    Nemunaitis, J.J.5    Jablons, D.M.6
  • 114
    • 77649224315 scopus 로고    scopus 로고
    • Synthesis and biological evaluation of polysulfated oligosaccharide glycosides as inhibitors of angiogenesis and tumor growth
    • Johnstone KD, Karoli T, Liu L, Dredge K, Copeman E, Li CP, et al. (2010). Synthesis and biological evaluation of polysulfated oligosaccharide glycosides as inhibitors of angiogenesis and tumor growth. J Med Chem 53: 1686-1699.
    • (2010) J Med Chem , vol.53 , pp. 1686-1699
    • Johnstone, K.D.1    Karoli, T.2    Liu, L.3    Dredge, K.4    Copeman, E.5    Li, C.P.6
  • 115
    • 63049104211 scopus 로고    scopus 로고
    • Microenvironmental regulation of metastasis
    • Joyce JA, Pollard JW, (2009). Microenvironmental regulation of metastasis. Nat Rev Cancer 9: 239-252.
    • (2009) Nat Rev Cancer , vol.9 , pp. 239-252
    • Joyce, J.A.1    Pollard, J.W.2
  • 116
    • 33746548452 scopus 로고    scopus 로고
    • Predicting benefit from anti-angiogenic agents in malignancy
    • Jubb AM, Oates AJ, Holden S, Koeppen H, (2006). Predicting benefit from anti-angiogenic agents in malignancy. Nat Rev Cancer 6: 626-635.
    • (2006) Nat Rev Cancer , vol.6 , pp. 626-635
    • Jubb, A.M.1    Oates, A.J.2    Holden, S.3    Koeppen, H.4
  • 117
    • 0037208589 scopus 로고    scopus 로고
    • Phase II, randomized trial comparing bevacizumab plus fluorouracil (FU)/leucovorin (LV) with FU/LV alone in patients with metastatic colorectal cancer
    • Kabbinavar F, Hurwitz HI, Fehrenbacher L, Meropol NJ, Novotny WF, Lieberman G, et al. (2003). Phase II, randomized trial comparing bevacizumab plus fluorouracil (FU)/leucovorin (LV) with FU/LV alone in patients with metastatic colorectal cancer. J Clin Oncol 21: 60-65.
    • (2003) J Clin Oncol , vol.21 , pp. 60-65
    • Kabbinavar, F.1    Hurwitz, H.I.2    Fehrenbacher, L.3    Meropol, N.J.4    Novotny, W.F.5    Lieberman, G.6
  • 119
    • 64049109575 scopus 로고    scopus 로고
    • Profiling of angiogenic cytokines produced by hormone- and drug-refractory prostate cancer cell lines, PC-3 and DU-145 before and after treatment with gossypol
    • Karaca B, Kucukzeybek Y, Gorumlu G, Erten C, Gul MK, Cengiz E, et al. (2008). Profiling of angiogenic cytokines produced by hormone- and drug-refractory prostate cancer cell lines, PC-3 and DU-145 before and after treatment with gossypol. Eur Cytokine Netw 19: 176-184.
    • (2008) Eur Cytokine Netw , vol.19 , pp. 176-184
    • Karaca, B.1    Kucukzeybek, Y.2    Gorumlu, G.3    Erten, C.4    Gul, M.K.5    Cengiz, E.6
  • 120
    • 20444456293 scopus 로고    scopus 로고
    • Bcl-2 acts in a proangiogenic signaling pathway through nuclear factor-kappaB and CXC chemokines
    • Karl E, Warner K, Zeitlin B, Kaneko T, Wurtzel L, Jin T, et al. (2005). Bcl-2 acts in a proangiogenic signaling pathway through nuclear factor-kappaB and CXC chemokines. Cancer Res 65: 5063-5069.
    • (2005) Cancer Res , vol.65 , pp. 5063-5069
    • Karl, E.1    Warner, K.2    Zeitlin, B.3    Kaneko, T.4    Wurtzel, L.5    Jin, T.6
  • 121
    • 0036780251 scopus 로고    scopus 로고
    • Clinical translation of angiogenesis inhibitors
    • Kerbel R, Folkman J, (2002). Clinical translation of angiogenesis inhibitors. Nat Rev Cancer 2: 727-739.
    • (2002) Nat Rev Cancer , vol.2 , pp. 727-739
    • Kerbel, R.1    Folkman, J.2
  • 122
    • 0034131079 scopus 로고    scopus 로고
    • 'Accidental' anti-angiogenic drugs. Anti-oncogene directed signal transduction inhibitors and conventional chemotherapeutic agents as examples
    • Kerbel RS, Viloria-Petit A, Klement G, Rak J, (2000). 'Accidental' anti-angiogenic drugs. Anti-oncogene directed signal transduction inhibitors and conventional chemotherapeutic agents as examples. Eur J Cancer 36: 1248-1257.
    • (2000) Eur J Cancer , vol.36 , pp. 1248-1257
    • Kerbel, R.S.1    Viloria-Petit, A.2    Klement, G.3    Rak, J.4
  • 123
    • 77953770159 scopus 로고    scopus 로고
    • The farnesyltransferase inhibitor LB42708 suppresses vascular endothelial growth factor-induced angiogenesis by inhibiting ras-dependent mitogen-activated protein kinase and phosphatidylinositol 3-kinase/Akt signal pathways
    • Kim CK, Choi YK, Lee H, Ha KS, Won MH, Kwon YG, et al. (2010). The farnesyltransferase inhibitor LB42708 suppresses vascular endothelial growth factor-induced angiogenesis by inhibiting ras-dependent mitogen-activated protein kinase and phosphatidylinositol 3-kinase/Akt signal pathways. Mol Pharmacol 78: 142-150.
    • (2010) Mol Pharmacol , vol.78 , pp. 142-150
    • Kim, C.K.1    Choi, Y.K.2    Lee, H.3    Ha, K.S.4    Won, M.H.5    Kwon, Y.G.6
  • 124
    • 17644383328 scopus 로고    scopus 로고
    • Chemosensitization by STI571 targeting the platelet-derived growth factor/platelet-derived growth factor receptor-signaling pathway in the tumor progression and angiogenesis of gastric carcinoma
    • Kim R, Emi M, Arihiro K, Tanabe K, Uchida Y, Toge T, (2005). Chemosensitization by STI571 targeting the platelet-derived growth factor/platelet-derived growth factor receptor-signaling pathway in the tumor progression and angiogenesis of gastric carcinoma. Cancer 103: 1800-1809.
    • (2005) Cancer , vol.103 , pp. 1800-1809
    • Kim, R.1    Emi, M.2    Arihiro, K.3    Tanabe, K.4    Uchida, Y.5    Toge, T.6
  • 125
    • 0034991938 scopus 로고    scopus 로고
    • Resveratrol isolated from Polygonum cuspidatum root prevents tumor growth and metastasis to lung and tumor-induced neovascularization in Lewis lung carcinoma-bearing mice
    • Kimura Y, Okuda H, (2001). Resveratrol isolated from Polygonum cuspidatum root prevents tumor growth and metastasis to lung and tumor-induced neovascularization in Lewis lung carcinoma-bearing mice. J Nutr 131: 1844-1849.
    • (2001) J Nutr , vol.131 , pp. 1844-1849
    • Kimura, Y.1    Okuda, H.2
  • 126
    • 33947612000 scopus 로고    scopus 로고
    • Tyrosine kinase inhibitor SU6668 represses chondrosarcoma growth via antiangiogenesis in vivo
    • Klenke FM, Abdollahi A, Bertl E, Gebhard MM, Ewerbeck V, Huber PE, et al. (2007). Tyrosine kinase inhibitor SU6668 represses chondrosarcoma growth via antiangiogenesis in vivo. BMC Cancer 7: 49.
    • (2007) BMC Cancer , vol.7 , pp. 49
    • Klenke, F.M.1    Abdollahi, A.2    Bertl, E.3    Gebhard, M.M.4    Ewerbeck, V.5    Huber, P.E.6
  • 127
    • 84869155416 scopus 로고    scopus 로고
    • A phase I/II trial of vandetanib for patients with recurrent malignant glioma
    • Kreisl TN, McNeill KA, Sul J, Iwamoto FM, Shih J, Fine HA, (2012). A phase I/II trial of vandetanib for patients with recurrent malignant glioma. Neuro Oncol 14: 1519-1526.
    • (2012) Neuro Oncol , vol.14 , pp. 1519-1526
    • Kreisl, T.N.1    McNeill, K.A.2    Sul, J.3    Iwamoto, F.M.4    Shih, J.5    Fine, H.A.6
  • 128
    • 66049154097 scopus 로고    scopus 로고
    • M-CSF inhibition selectively targets pathological angiogenesis and lymphangiogenesis
    • Kubota Y, Takubo K, Shimizu T, Ohno H, Kishi K, Shibuya M, et al. (2009). M-CSF inhibition selectively targets pathological angiogenesis and lymphangiogenesis. J Exp Med 206: 1089-1102.
    • (2009) J Exp Med , vol.206 , pp. 1089-1102
    • Kubota, Y.1    Takubo, K.2    Shimizu, T.3    Ohno, H.4    Kishi, K.5    Shibuya, M.6
  • 129
    • 0037058575 scopus 로고    scopus 로고
    • Interference with TGF-beta1 and -beta3 in tumor stroma lowers tumor interstitial fluid pressure independently of growth in experimental carcinoma
    • Lammerts E, Roswall P, Sundberg C, Gotwals PJ, Koteliansky VE, Reed RK, et al. (2002). Interference with TGF-beta1 and -beta3 in tumor stroma lowers tumor interstitial fluid pressure independently of growth in experimental carcinoma. Int J Cancer 102: 453-462.
    • (2002) Int J Cancer , vol.102 , pp. 453-462
    • Lammerts, E.1    Roswall, P.2    Sundberg, C.3    Gotwals, P.J.4    Koteliansky, V.E.5    Reed, R.K.6
  • 130
    • 34147123235 scopus 로고    scopus 로고
    • Inhibition of heat shock protein 90 impairs epidermal growth factor-mediated signaling in gastric cancer cells and reduces tumor growth and vascularization in vivo
    • Lang SA, Klein D, Moser C, Gaumann A, Glockzin G, Dahlke MH, et al. (2007). Inhibition of heat shock protein 90 impairs epidermal growth factor-mediated signaling in gastric cancer cells and reduces tumor growth and vascularization in vivo. Mol Cancer Ther 6: 1123-1132.
    • (2007) Mol Cancer Ther , vol.6 , pp. 1123-1132
    • Lang, S.A.1    Klein, D.2    Moser, C.3    Gaumann, A.4    Glockzin, G.5    Dahlke, M.H.6
  • 131
    • 84865552505 scopus 로고    scopus 로고
    • Vandetanib in locally advanced or metastatic differentiated thyroid cancer: A randomised, double-blind, phase 2 trial
    • Leboulleux S, Bastholt L, Krause T, de la Fouchardiere C, Tennvall J, Awada A, et al. (2012). Vandetanib in locally advanced or metastatic differentiated thyroid cancer: a randomised, double-blind, phase 2 trial. Lancet Oncol 13: 897-905.
    • (2012) Lancet Oncol , vol.13 , pp. 897-905
    • Leboulleux, S.1    Bastholt, L.2    Krause, T.3    De La Fouchardiere, C.4    Tennvall, J.5    Awada, A.6
  • 132
    • 80053561888 scopus 로고    scopus 로고
    • Randomized phase II placebo-controlled trial of maintenance therapy using the oral triple angiokinase inhibitor BIBF 1120 after chemotherapy for relapsed ovarian cancer
    • Ledermann JA, Hackshaw A, Kaye S, Jayson G, Gabra H, McNeish I, et al. (2011). Randomized phase II placebo-controlled trial of maintenance therapy using the oral triple angiokinase inhibitor BIBF 1120 after chemotherapy for relapsed ovarian cancer. J Clin Oncol 29: 3798-3804.
    • (2011) J Clin Oncol , vol.29 , pp. 3798-3804
    • Ledermann, J.A.1    Hackshaw, A.2    Kaye, S.3    Jayson, G.4    Gabra, H.5    McNeish, I.6
  • 133
    • 84872693386 scopus 로고    scopus 로고
    • Hypoxia-inducible Factor-1 (HIF-1)-independent hypoxia response of the small heat shock protein hsp-16.1 gene regulated by chromatin-remodeling factors in the nematode Caenorhabditis elegans
    • Lee J, (2013). Hypoxia-inducible Factor-1 (HIF-1)-independent hypoxia response of the small heat shock protein hsp-16.1 gene regulated by chromatin-remodeling factors in the nematode Caenorhabditis elegans. J Biol Chem 288: 1582-1589.
    • (2013) J Biol Chem , vol.288 , pp. 1582-1589
    • Lee, J.1
  • 134
    • 84861720010 scopus 로고    scopus 로고
    • Vandetanib versus placebo in patients with advanced non-small-cell lung cancer after prior therapy with an epidermal growth factor receptor tyrosine kinase inhibitor: A randomized, double-blind phase III trial (ZEPHYR)
    • Lee JS, Hirsh V, Park K, Qin S, Blajman CR, Perng RP, et al. (2012). Vandetanib versus placebo in patients with advanced non-small-cell lung cancer after prior therapy with an epidermal growth factor receptor tyrosine kinase inhibitor: a randomized, double-blind phase III trial (ZEPHYR). J Clin Oncol 30: 1114-1121.
    • (2012) J Clin Oncol , vol.30 , pp. 1114-1121
    • Lee, J.S.1    Hirsh, V.2    Park, K.3    Qin, S.4    Blajman, C.R.5    Perng, R.P.6
  • 135
    • 0036493984 scopus 로고    scopus 로고
    • Relation of hypoxia-inducible factor-2 alpha (HIF-2 alpha) expression in tumor-infiltrative macrophages to tumor angiogenesis and the oxidative thymidine phosphorylase pathway in human breast cancer
    • Leek RD, Talks KL, Pezzella F, Turley H, Campo L, Brown NS, et al. (2002). Relation of hypoxia-inducible factor-2 alpha (HIF-2 alpha) expression in tumor-infiltrative macrophages to tumor angiogenesis and the oxidative thymidine phosphorylase pathway in human breast cancer. Cancer Res 62: 1326-1329.
    • (2002) Cancer Res , vol.62 , pp. 1326-1329
    • Leek, R.D.1    Talks, K.L.2    Pezzella, F.3    Turley, H.4    Campo, L.5    Brown, N.S.6
  • 136
    • 0036033456 scopus 로고    scopus 로고
    • Vessel co-option: How tumors obtain blood supply in the absence of sprouting angiogenesis
    • Leenders WP, Kusters B, de Waal RM, (2002). Vessel co-option: how tumors obtain blood supply in the absence of sprouting angiogenesis. Endothelium 9: 83-87.
    • (2002) Endothelium , vol.9 , pp. 83-87
    • Leenders, W.P.1    Kusters, B.2    De Waal, R.M.3
  • 137
    • 31544441610 scopus 로고    scopus 로고
    • Distinct role of macrophages in different tumor microenvironments
    • Lewis CE, Pollard JW, (2006). Distinct role of macrophages in different tumor microenvironments. Cancer Res 66: 605-612.
    • (2006) Cancer Res , vol.66 , pp. 605-612
    • Lewis, C.E.1    Pollard, J.W.2
  • 138
    • 0037171951 scopus 로고    scopus 로고
    • Squalamine and cisplatin block angiogenesis and growth of human ovarian cancer cells with or without HER-2 gene overexpression
    • Li D, Williams JI, Pietras RJ, (2002). Squalamine and cisplatin block angiogenesis and growth of human ovarian cancer cells with or without HER-2 gene overexpression. Oncogene 21: 2805-2814.
    • (2002) Oncogene , vol.21 , pp. 2805-2814
    • Li, D.1    Williams, J.I.2    Pietras, R.J.3
  • 139
    • 81555207200 scopus 로고    scopus 로고
    • Tumor angiogenesis as a target for dietary cancer prevention
    • Li WW, Li VW, Hutnik M, Chiou AS, (2012). Tumor angiogenesis as a target for dietary cancer prevention. J Oncol 2012: 879623.
    • (2012) J Oncol , vol.2012 , pp. 879623
    • Li, W.W.1    Li, V.W.2    Hutnik, M.3    Chiou, A.S.4
  • 140
    • 33845767868 scopus 로고    scopus 로고
    • Macrophages regulate the angiogenic switch in a mouse model of breast cancer
    • Lin EY, Li JF, Gnatovskiy L, Deng Y, Zhu L, Grzesik DA, et al. (2006). Macrophages regulate the angiogenic switch in a mouse model of breast cancer. Cancer Res 66: 11238-11246.
    • (2006) Cancer Res , vol.66 , pp. 11238-11246
    • Lin, E.Y.1    Li, J.F.2    Gnatovskiy, L.3    Deng, Y.4    Zhu, L.5    Grzesik, D.A.6
  • 141
    • 84984569951 scopus 로고    scopus 로고
    • Heparanase inhibitor PI-88 as adjuvant therapy for hepatocellular carcinoma after curative resection: A randomized phase II trial for safety and optimal dosage
    • Liu CJ, Lee PH, Lin DY, Wu CC, Jeng LB, Lin PW, et al. (2009). Heparanase inhibitor PI-88 as adjuvant therapy for hepatocellular carcinoma after curative resection: a randomized phase II trial for safety and optimal dosage. J Hepatol 50: 958-968.
    • (2009) J Hepatol , vol.50 , pp. 958-968
    • Liu, C.J.1    Lee, P.H.2    Lin, D.Y.3    Wu, C.C.4    Jeng, L.B.5    Lin, P.W.6
  • 143
    • 77952673621 scopus 로고    scopus 로고
    • Mechanisms of resistance to anti-angiogenic therapy and development of third-generation anti-angiogenic drug candidates
    • Loges S, Schmidt T, Carmeliet P, (2010). Mechanisms of resistance to anti-angiogenic therapy and development of third-generation anti-angiogenic drug candidates. Genes Cancer 1: 12-25.
    • (2010) Genes Cancer , vol.1 , pp. 12-25
    • Loges, S.1    Schmidt, T.2    Carmeliet, P.3
  • 144
    • 3042755032 scopus 로고    scopus 로고
    • Insulin-like growth factor i is required for vessel remodeling in the adult brain
    • Lopez-Lopez C, LeRoith D, Torres-Aleman I, (2004). Insulin-like growth factor I is required for vessel remodeling in the adult brain. Proc Natl Acad Sci U S A 101: 9833-9838.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 9833-9838
    • Lopez-Lopez, C.1    Leroith, D.2    Torres-Aleman, I.3
  • 145
    • 34248190133 scopus 로고    scopus 로고
    • Low dose metronomic oral cyclophosphamide for hormone resistant prostate cancer: A phase II study
    • .:; discussion 2140
    • Lord R, Nair S, Schache A, Spicer J, Somaihah N, Khoo V, et al. (2007). Low dose metronomic oral cyclophosphamide for hormone resistant prostate cancer: a phase II study. J Urol 177: 2136-2140; discussion 2140.
    • (2007) J Urol , vol.177 , pp. 2136-2140
    • Lord, R.1    Nair, S.2    Schache, A.3    Spicer, J.4    Somaihah, N.5    Khoo, V.6
  • 146
    • 56749107194 scopus 로고    scopus 로고
    • The tumor microenvironment and its contribution to tumor evolution toward metastasis
    • Lorusso G, Ruegg C, (2008). The tumor microenvironment and its contribution to tumor evolution toward metastasis. Histochem Cell Biol 130: 1091-1103.
    • (2008) Histochem Cell Biol , vol.130 , pp. 1091-1103
    • Lorusso, G.1    Ruegg, C.2
  • 147
    • 57749092182 scopus 로고    scopus 로고
    • Combination of antiangiogenesis with chemotherapy for more effective cancer treatment
    • Ma J, Waxman DJ, (2008). Combination of antiangiogenesis with chemotherapy for more effective cancer treatment. Mol Cancer Ther 7: 3670-3684.
    • (2008) Mol Cancer Ther , vol.7 , pp. 3670-3684
    • Ma, J.1    Waxman, D.J.2
  • 148
    • 59449106047 scopus 로고    scopus 로고
    • Dominant effect of antiangiogenesis in combination therapy involving cyclophosphamide and axitinib
    • Ma J, Waxman DJ, (2009). Dominant effect of antiangiogenesis in combination therapy involving cyclophosphamide and axitinib. Clin Cancer Res 15: 578-588.
    • (2009) Clin Cancer Res , vol.15 , pp. 578-588
    • Ma, J.1    Waxman, D.J.2
  • 149
    • 79953330322 scopus 로고    scopus 로고
    • Antiangiogenesis enhances intratumoral drug retention
    • Ma J, Chen CS, Blute T, Waxman DJ, (2011). Antiangiogenesis enhances intratumoral drug retention. Cancer Res 71: 2675-2685.
    • (2011) Cancer Res , vol.71 , pp. 2675-2685
    • Ma, J.1    Chen, C.S.2    Blute, T.3    Waxman, D.J.4
  • 151
  • 152
    • 84873077884 scopus 로고    scopus 로고
    • Randomized phase II study of three doses of the integrin inhibitor cilengitide versus docetaxel as second-line treatment for patients with advanced non-small-cell lung cancer
    • Manegold C, Vansteenkiste J, Cardenal F, Schuette W, Woll PJ, Ulsperger E, et al. (2013). Randomized phase II study of three doses of the integrin inhibitor cilengitide versus docetaxel as second-line treatment for patients with advanced non-small-cell lung cancer. Invest New Drugs 31: 175-182.
    • (2013) Invest New Drugs , vol.31 , pp. 175-182
    • Manegold, C.1    Vansteenkiste, J.2    Cardenal, F.3    Schuette, W.4    Woll, P.J.5    Ulsperger, E.6
  • 153
    • 38949145737 scopus 로고    scopus 로고
    • Antiangiogenic therapy with mammalian target of rapamycin inhibitor RAD001 (Everolimus) increases radiosensitivity in solid cancer
    • Manegold PC, Paringer C, Kulka U, Krimmel K, Eichhorn ME, Wilkowski R, et al. (2008). Antiangiogenic therapy with mammalian target of rapamycin inhibitor RAD001 (Everolimus) increases radiosensitivity in solid cancer. Clin Cancer Res 14: 892-900.
    • (2008) Clin Cancer Res , vol.14 , pp. 892-900
    • Manegold, P.C.1    Paringer, C.2    Kulka, U.3    Krimmel, K.4    Eichhorn, M.E.5    Wilkowski, R.6
  • 154
    • 70949104409 scopus 로고    scopus 로고
    • JNJ-28312141, a novel orally active colony-stimulating factor-1 receptor/FMS-related receptor tyrosine kinase-3 receptor tyrosine kinase inhibitor with potential utility in solid tumors, bone metastases, and acute myeloid leukemia
    • Manthey CL, Johnson DL, Illig CR, Tuman RW, Zhou Z, Baker JF, et al. (2009). JNJ-28312141, a novel orally active colony-stimulating factor-1 receptor/FMS-related receptor tyrosine kinase-3 receptor tyrosine kinase inhibitor with potential utility in solid tumors, bone metastases, and acute myeloid leukemia. Mol Cancer Ther 8: 3151-3161.
    • (2009) Mol Cancer Ther , vol.8 , pp. 3151-3161
    • Manthey, C.L.1    Johnson, D.L.2    Illig, C.R.3    Tuman, R.W.4    Zhou, Z.5    Baker, J.F.6
  • 155
    • 33845910687 scopus 로고    scopus 로고
    • A monoclonal antibody inhibits gelatinase B/MMP-9 by selective binding to part of the catalytic domain and not to the fibronectin or zinc binding domains
    • Martens E, Leyssen A, Van Aelst I, Fiten P, Piccard H, Hu J, et al. (2007). A monoclonal antibody inhibits gelatinase B/MMP-9 by selective binding to part of the catalytic domain and not to the fibronectin or zinc binding domains. Biochim Biophys Acta 1770: 178-186.
    • (2007) Biochim Biophys Acta , vol.1770 , pp. 178-186
    • Martens, E.1    Leyssen, A.2    Van Aelst, I.3    Fiten, P.4    Piccard, H.5    Hu, J.6
  • 156
    • 77950356821 scopus 로고    scopus 로고
    • Proteasome inhibitor MG132 inhibits angiogenesis in pancreatic cancer by blocking NF-kappaB activity
    • Matsuo Y, Sawai H, Ochi N, Yasuda A, Sakamoto M, Takahashi H, et al. (2009). Proteasome inhibitor MG132 inhibits angiogenesis in pancreatic cancer by blocking NF-kappaB activity. Dig Dis Sci 55: 1167-1176.
    • (2009) Dig Dis Sci , vol.55 , pp. 1167-1176
    • Matsuo, Y.1    Sawai, H.2    Ochi, N.3    Yasuda, A.4    Sakamoto, M.5    Takahashi, H.6
  • 157
    • 21144433924 scopus 로고    scopus 로고
    • Identification of a transiently exposed VE-cadherin epitope that allows for specific targeting of an antibody to the tumor neovasculature
    • May C, Doody JF, Abdullah R, Balderes P, Xu X, Chen CP, et al. (2005). Identification of a transiently exposed VE-cadherin epitope that allows for specific targeting of an antibody to the tumor neovasculature. Blood 105: 4337-4344.
    • (2005) Blood , vol.105 , pp. 4337-4344
    • May, C.1    Doody, J.F.2    Abdullah, R.3    Balderes, P.4    Xu, X.5    Chen, C.P.6
  • 158
    • 84862184774 scopus 로고    scopus 로고
    • Phase i study of cetuximab, irinotecan, and vandetanib (ZD6474) as therapy for patients with previously treated metastastic colorectal cancer
    • Meyerhardt JA, Ancukiewicz M, Abrams TA, Schrag D, Enzinger PC, Chan JA, et al. (2012). Phase I study of cetuximab, irinotecan, and vandetanib (ZD6474) as therapy for patients with previously treated metastastic colorectal cancer. PLoS One 7: e38231.
    • (2012) PLoS One , vol.7
    • Meyerhardt, J.A.1    Ancukiewicz, M.2    Abrams, T.A.3    Schrag, D.4    Enzinger, P.C.5    Chan, J.A.6
  • 159
    • 84863918824 scopus 로고    scopus 로고
    • Bevacizumab advanced melanoma (BEAM) was a positive trial
    • author reply 2023-2024
    • Minor DR, (2012). Bevacizumab advanced melanoma (BEAM) was a positive trial. J Clin Oncol 30: 2023; author reply 2023-2024.
    • (2012) J Clin Oncol , vol.30 , pp. 2023
    • Minor, D.R.1
  • 160
    • 35348909046 scopus 로고    scopus 로고
    • Hypoxia inducible factor-1 independent pathways in tumor angiogenesis
    • Mizukami Y, Kohgo Y, Chung DC, (2007). Hypoxia inducible factor-1 independent pathways in tumor angiogenesis. Clin Cancer Res 13: 5670-5674.
    • (2007) Clin Cancer Res , vol.13 , pp. 5670-5674
    • Mizukami, Y.1    Kohgo, Y.2    Chung, D.C.3
  • 161
    • 84857626952 scopus 로고    scopus 로고
    • Bevacizumab in the treatment of metastatic breast cancer: Friend or foe?
    • Montero AJ, Escobar M, Lopes G, Gluck S, Vogel C, (2012). Bevacizumab in the treatment of metastatic breast cancer: friend or foe? Curr Oncol Rep 14: 1-11.
    • (2012) Curr Oncol Rep , vol.14 , pp. 1-11
    • Montero, A.J.1    Escobar, M.2    Lopes, G.3    Gluck, S.4    Vogel, C.5
  • 162
    • 84865695718 scopus 로고    scopus 로고
    • Targeting HSP90 by the novel inhibitor NVP-AUY922 reduces growth and angiogenesis of pancreatic cancer
    • Moser C, Lang SA, Hackl C, Wagner C, Scheiffert E, Schlitt HJ, et al. (2012). Targeting HSP90 by the novel inhibitor NVP-AUY922 reduces growth and angiogenesis of pancreatic cancer. Anticancer Res 32: 2551-2561.
    • (2012) Anticancer Res , vol.32 , pp. 2551-2561
    • Moser, C.1    Lang, S.A.2    Hackl, C.3    Wagner, C.4    Scheiffert, E.5    Schlitt, H.J.6
  • 163
    • 67651172970 scopus 로고    scopus 로고
    • Targeting of tumor blood vessels: A phage-displayed tumor-homing peptide
    • Mueller J, Gaertner FC, Blechert B, Janssen KP, Essler M, (2009). Targeting of tumor blood vessels: a phage-displayed tumor-homing peptide specifically binds to matrix metalloproteinase-2-processed collagen IV and blocks angiogenesis in vivo. Mol Cancer Res 7: 1078-1085.
    • (2009) Mol Cancer Res , vol.7 , pp. 1078-1085
    • Mueller, J.1    Gaertner, F.C.2    Blechert, B.3    Janssen, K.P.4    Essler, M.5
  • 164
    • 35748947260 scopus 로고    scopus 로고
    • Type IV collagen-derived angiogenesis inhibitors
    • Mundel TM, Kalluri R, (2007). Type IV collagen-derived angiogenesis inhibitors. Microvasc Res 74: 85-89.
    • (2007) Microvasc Res , vol.74 , pp. 85-89
    • Mundel, T.M.1    Kalluri, R.2
  • 165
    • 79951873360 scopus 로고    scopus 로고
    • Lipid mediators in life science
    • Murakami M, (2011). Lipid mediators in life science. Exp Anim 60: 7-20.
    • (2011) Exp Anim , vol.60 , pp. 7-20
    • Murakami, M.1
  • 167
    • 47949090079 scopus 로고    scopus 로고
    • The role of myeloid cells in the promotion of tumour angiogenesis
    • Murdoch C, Muthana M, Coffelt SB, Lewis CE, (2008). The role of myeloid cells in the promotion of tumour angiogenesis. Nat Rev Cancer 8: 618-631.
    • (2008) Nat Rev Cancer , vol.8 , pp. 618-631
    • Murdoch, C.1    Muthana, M.2    Coffelt, S.B.3    Lewis, C.E.4
  • 169
    • 33746257413 scopus 로고    scopus 로고
    • Permeability properties of tumor surrogate blood vessels induced by VEGF-A
    • Nagy JA, Feng D, Vasile E, Wong WH, Shih SC, Dvorak AM, et al. (2006). Permeability properties of tumor surrogate blood vessels induced by VEGF-A. Lab Invest 86: 767-780.
    • (2006) Lab Invest , vol.86 , pp. 767-780
    • Nagy, J.A.1    Feng, D.2    Vasile, E.3    Wong, W.H.4    Shih, S.C.5    Dvorak, A.M.6
  • 170
    • 0037591510 scopus 로고    scopus 로고
    • Neural-cadherin expression associated with angiogenesis in non-small-cell lung cancer patients
    • Nakashima T, Huang C, Liu D, Kameyama K, Masuya D, Kobayashi S, et al. (2003). Neural-cadherin expression associated with angiogenesis in non-small-cell lung cancer patients. Br J Cancer 88: 1727-1733.
    • (2003) Br J Cancer , vol.88 , pp. 1727-1733
    • Nakashima, T.1    Huang, C.2    Liu, D.3    Kameyama, K.4    Masuya, D.5    Kobayashi, S.6
  • 171
    • 33645657886 scopus 로고    scopus 로고
    • The vascular targeting property of paclitaxel is enhanced by SU6668, a receptor tyrosine kinase inhibitor, causing apoptosis of endothelial cells and inhibition of angiogenesis
    • Naumova E, Ubezio P, Garofalo A, Borsotti P, Cassis L, Riccardi E, et al. (2006). The vascular targeting property of paclitaxel is enhanced by SU6668, a receptor tyrosine kinase inhibitor, causing apoptosis of endothelial cells and inhibition of angiogenesis. Clin Cancer Res 12: 1839-1849.
    • (2006) Clin Cancer Res , vol.12 , pp. 1839-1849
    • Naumova, E.1    Ubezio, P.2    Garofalo, A.3    Borsotti, P.4    Cassis, L.5    Riccardi, E.6
  • 172
    • 84871979382 scopus 로고    scopus 로고
    • Phase i and clinical pharmacology study of bevacizumab, sorafenib, and low-dose cyclophosphamide in children and young adults with refractory/recurrent solid tumors
    • Navid F, Baker SD, McCarville MB, Stewart CF, Billups CA, Wu J, et al. (2013). Phase I and clinical pharmacology study of bevacizumab, sorafenib, and low-dose cyclophosphamide in children and young adults with refractory/recurrent solid tumors. Clin Cancer Res 19: 236-246.
    • (2013) Clin Cancer Res , vol.19 , pp. 236-246
    • Navid, F.1    Baker, S.D.2    McCarville, M.B.3    Stewart, C.F.4    Billups, C.A.5    Wu, J.6
  • 173
    • 0012433771 scopus 로고    scopus 로고
    • Effects of the proteasome inhibitor PS-341 on apoptosis and angiogenesis in orthotopic human pancreatic tumor xenografts
    • Nawrocki ST, Bruns CJ, Harbison MT, Bold RJ, Gotsch BS, Abbruzzese JL, et al. (2002). Effects of the proteasome inhibitor PS-341 on apoptosis and angiogenesis in orthotopic human pancreatic tumor xenografts. Mol Cancer Ther 1: 1243-1253.
    • (2002) Mol Cancer Ther , vol.1 , pp. 1243-1253
    • Nawrocki, S.T.1    Bruns, C.J.2    Harbison, M.T.3    Bold, R.J.4    Gotsch, B.S.5    Abbruzzese, J.L.6
  • 174
    • 79960999855 scopus 로고    scopus 로고
    • Oral/metronomic cyclophosphamide-based chemotherapy as option for patients with castration-refractory prostate cancer: Review of the literature
    • Nelius T, Rinard K, Filleur S, (2011). Oral/metronomic cyclophosphamide-based chemotherapy as option for patients with castration-refractory prostate cancer: review of the literature. Cancer Treat Rev 37: 444-455.
    • (2011) Cancer Treat Rev , vol.37 , pp. 444-455
    • Nelius, T.1    Rinard, K.2    Filleur, S.3
  • 175
    • 20144379162 scopus 로고    scopus 로고
    • Endogenous inhibitors of angiogenesis
    • Nyberg P, Xie L, Kalluri R, (2005). Endogenous inhibitors of angiogenesis. Cancer Res 65: 3967-3979.
    • (2005) Cancer Res , vol.65 , pp. 3967-3979
    • Nyberg, P.1    Xie, L.2    Kalluri, R.3
  • 176
    • 0031454617 scopus 로고    scopus 로고
    • Endostatin: An endogenous inhibitor of angiogenesis and tumor growth
    • O'Reilly MS, Boehm T, Shing Y, Fukai N, Vasios G, Lane WS, et al. (1997). Endostatin: an endogenous inhibitor of angiogenesis and tumor growth. Cell 88: 277-285.
    • (1997) Cell , vol.88 , pp. 277-285
    • O'Reilly, M.S.1    Boehm, T.2    Shing, Y.3    Fukai, N.4    Vasios, G.5    Lane, W.S.6
  • 177
    • 80053573446 scopus 로고    scopus 로고
    • Bevacizumab in combination with chemotherapy as first-line therapy in advanced gastric cancer: A randomized, double-blind, placebo-controlled phase III study
    • Ohtsu A, Shah MA, Van Cutsem E, Rha SY, Sawaki A, Park SR, et al. (2011). Bevacizumab in combination with chemotherapy as first-line therapy in advanced gastric cancer: a randomized, double-blind, placebo-controlled phase III study. J Clin Oncol 29: 3968-3976.
    • (2011) J Clin Oncol , vol.29 , pp. 3968-3976
    • Ohtsu, A.1    Shah, M.A.2    Van Cutsem, E.3    Rha, S.Y.4    Sawaki, A.5    Park, S.R.6
  • 178
    • 79956046608 scopus 로고    scopus 로고
    • (-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis
    • Pang X, Wu Y, Lu B, Chen J, Wang J, Yi Z, et al. (2011). (-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis. Mol Cancer Ther 10: 795-805.
    • (2011) Mol Cancer Ther , vol.10 , pp. 795-805
    • Pang, X.1    Wu, Y.2    Lu, B.3    Chen, J.4    Wang, J.5    Yi, Z.6
  • 179
    • 33846208703 scopus 로고    scopus 로고
    • Combination therapy with IFN-alpha plus bortezomib induces apoptosis and inhibits angiogenesis in human bladder cancer cells
    • Papageorgiou A, Kamat A, Benedict WF, Dinney C, McConkey DJ, (2006). Combination therapy with IFN-alpha plus bortezomib induces apoptosis and inhibits angiogenesis in human bladder cancer cells. Mol Cancer Ther 5: 3032-3041.
    • (2006) Mol Cancer Ther , vol.5 , pp. 3032-3041
    • Papageorgiou, A.1    Kamat, A.2    Benedict, W.F.3    Dinney, C.4    McConkey, D.J.5
  • 180
    • 84858799883 scopus 로고    scopus 로고
    • Cyclophosphamide-based metronomic chemotherapy: After 10 years of experience, where do we stand and where are we going?
    • Penel N, Adenis A, Bocci G, (2012). Cyclophosphamide-based metronomic chemotherapy: after 10 years of experience, where do we stand and where are we going? Crit Rev Oncol Hematol 82: 40-50.
    • (2012) Crit Rev Oncol Hematol , vol.82 , pp. 40-50
    • Penel, N.1    Adenis, A.2    Bocci, G.3
  • 181
    • 0036692256 scopus 로고    scopus 로고
    • Angiogenesis in health and disease: Insights into basic mechanisms and therapeutic opportunities
    • Polverini PJ, (2002). Angiogenesis in health and disease: insights into basic mechanisms and therapeutic opportunities. J Dent Educ 66: 962-975.
    • (2002) J Dent Educ , vol.66 , pp. 962-975
    • Polverini, P.J.1
  • 183
    • 0038037735 scopus 로고    scopus 로고
    • Regulation of angiogenesis by hypoxia: Role of the HIF system
    • Pugh CW, Ratcliffe PJ, (2003). Regulation of angiogenesis by hypoxia: role of the HIF system. Nat Med 9: 677-684.
    • (2003) Nat Med , vol.9 , pp. 677-684
    • Pugh, C.W.1    Ratcliffe, P.J.2
  • 184
    • 4644364508 scopus 로고    scopus 로고
    • The histone deacetylase inhibitor NVP-LAQ824 inhibits angiogenesis and has a greater antitumor effect in combination with the vascular endothelial growth factor receptor tyrosine kinase inhibitor PTK787/ZK222584
    • Qian DZ, Wang X, Kachhap SK, Kato Y, Wei Y, Zhang L, et al. (2004). The histone deacetylase inhibitor NVP-LAQ824 inhibits angiogenesis and has a greater antitumor effect in combination with the vascular endothelial growth factor receptor tyrosine kinase inhibitor PTK787/ZK222584. Cancer Res 64: 6626-6634.
    • (2004) Cancer Res , vol.64 , pp. 6626-6634
    • Qian, D.Z.1    Wang, X.2    Kachhap, S.K.3    Kato, Y.4    Wei, Y.5    Zhang, L.6
  • 185
    • 84877613865 scopus 로고    scopus 로고
    • The vascular permeabilizing factors histamine and serotonin induce angiogenesis through TR3/Nur77 and subsequently truncate it through thrombospondin-1
    • Qin L, Zhao D, Xu J, Ren X, Terwilliger EF, Parangi S, et al. (2013). The vascular permeabilizing factors histamine and serotonin induce angiogenesis through TR3/Nur77 and subsequently truncate it through thrombospondin-1. Blood 121: 2154-2164.
    • (2013) Blood , vol.121 , pp. 2154-2164
    • Qin, L.1    Zhao, D.2    Xu, J.3    Ren, X.4    Terwilliger, E.F.5    Parangi, S.6
  • 186
    • 84868621665 scopus 로고    scopus 로고
    • Cilengitide: A prototypic integrin inhibitor for the treatment of glioblastoma and other malignancies
    • Reardon DA, Cheresh D, (2011). Cilengitide: a prototypic integrin inhibitor for the treatment of glioblastoma and other malignancies. Genes Cancer 2: 1159-1165.
    • (2011) Genes Cancer , vol.2 , pp. 1159-1165
    • Reardon, D.A.1    Cheresh, D.2
  • 187
    • 61649113720 scopus 로고    scopus 로고
    • Endogenous inhibitors of angiogenesis: A historical review
    • Ribatti D, (2009). Endogenous inhibitors of angiogenesis: a historical review. Leuk Res 33: 638-644.
    • (2009) Leuk Res , vol.33 , pp. 638-644
    • Ribatti, D.1
  • 188
    • 84856014603 scopus 로고    scopus 로고
    • Intussusceptive microvascular growth in tumors
    • Ribatti D, Djonov V, (2012). Intussusceptive microvascular growth in tumors. Cancer Lett 316: 126-131.
    • (2012) Cancer Lett , vol.316 , pp. 126-131
    • Ribatti, D.1    Djonov, V.2
  • 189
    • 80054075147 scopus 로고    scopus 로고
    • Tumour macrophages as potential targets of bisphosphonates
    • Rogers TL, Holen I, (2011). Tumour macrophages as potential targets of bisphosphonates. J Transl Med 9: 177.
    • (2011) J Transl Med , vol.9 , pp. 177
    • Rogers, T.L.1    Holen, I.2
  • 190
    • 33947416658 scopus 로고    scopus 로고
    • Sunitinib: A VEGF and PDGF receptor protein kinase and angiogenesis inhibitor
    • Roskoski R, Jr, (2007). Sunitinib: a VEGF and PDGF receptor protein kinase and angiogenesis inhibitor. Biochem Biophys Res Commun 356: 323-328.
    • (2007) Biochem Biophys Res Commun , vol.356 , pp. 323-328
    • Roskoski, Jr.R.1
  • 191
    • 78650215449 scopus 로고    scopus 로고
    • Long-term effect of aspirin on colorectal cancer incidence and mortality: 20-year follow-up of five randomised trials
    • Rothwell PM, Wilson M, Elwin CE, Norrving B, Algra A, Warlow CP, et al. (2010). Long-term effect of aspirin on colorectal cancer incidence and mortality: 20-year follow-up of five randomised trials. Lancet 376: 1741-1750.
    • (2010) Lancet , vol.376 , pp. 1741-1750
    • Rothwell, P.M.1    Wilson, M.2    Elwin, C.E.3    Norrving, B.4    Algra, A.5    Warlow, C.P.6
  • 192
    • 36749040908 scopus 로고    scopus 로고
    • VEGF Trap complex formation measures production rates of VEGF, providing a biomarker for predicting efficacious angiogenic blockade
    • Rudge JS, Holash J, Hylton D, Russell M, Jiang S, Leidich R, et al. (2007). VEGF Trap complex formation measures production rates of VEGF, providing a biomarker for predicting efficacious angiogenic blockade. Proc Natl Acad Sci U S A 104: 18363-18370.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 18363-18370
    • Rudge, J.S.1    Holash, J.2    Hylton, D.3    Russell, M.4    Jiang, S.5    Leidich, R.6
  • 193
    • 77949762340 scopus 로고    scopus 로고
    • Targeting of drugs and nanoparticles to tumors
    • Ruoslahti E, Bhatia SN, Sailor MJ, (2010). Targeting of drugs and nanoparticles to tumors. J Cell Biol 188: 759-768.
    • (2010) J Cell Biol , vol.188 , pp. 759-768
    • Ruoslahti, E.1    Bhatia, S.N.2    Sailor, M.J.3
  • 194
    • 79951981180 scopus 로고    scopus 로고
    • Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration
    • Sabbadini RA, (2011). Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration. Br J Pharmacol 162: 1225-1238.
    • (2011) Br J Pharmacol , vol.162 , pp. 1225-1238
    • Sabbadini, R.A.1
  • 195
    • 33645470397 scopus 로고    scopus 로고
    • Benzoquinone ansamycin heat shock protein 90 inhibitors modulate multiple functions required for tumor angiogenesis
    • Sanderson S, Valenti M, Gowan S, Patterson L, Ahmad Z, Workman P, et al. (2006). Benzoquinone ansamycin heat shock protein 90 inhibitors modulate multiple functions required for tumor angiogenesis. Mol Cancer Ther 5: 522-532.
    • (2006) Mol Cancer Ther , vol.5 , pp. 522-532
    • Sanderson, S.1    Valenti, M.2    Gowan, S.3    Patterson, L.4    Ahmad, Z.5    Workman, P.6
  • 197
    • 34547653957 scopus 로고    scopus 로고
    • Repeated intermittent low-dose therapy with zoledronic acid induces an early, sustained, and long-lasting decrease of peripheral vascular endothelial growth factor levels in cancer patients
    • Santini D, Vincenzi B, Galluzzo S, Battistoni F, Rocci L, Venditti O, et al. (2007). Repeated intermittent low-dose therapy with zoledronic acid induces an early, sustained, and long-lasting decrease of peripheral vascular endothelial growth factor levels in cancer patients. Clin Cancer Res 13 (15 Pt 1): 4482-4486.
    • (2007) Clin Cancer Res , vol.13 , Issue.15 PART 1 , pp. 4482-4486
    • Santini, D.1    Vincenzi, B.2    Galluzzo, S.3    Battistoni, F.4    Rocci, L.5    Venditti, O.6
  • 198
    • 84862502742 scopus 로고    scopus 로고
    • Clinical efficacy and safety of bevacizumab monotherapy in patients with metastatic melanoma: Predictive importance of induced early hypertension
    • Schuster C, Eikesdal HP, Puntervoll H, Geisler J, Geisler S, Heinrich D, et al. (2012). Clinical efficacy and safety of bevacizumab monotherapy in patients with metastatic melanoma: predictive importance of induced early hypertension. PLoS One 7: e38364.
    • (2012) PLoS One , vol.7
    • Schuster, C.1    Eikesdal, H.P.2    Puntervoll, H.3    Geisler, J.4    Geisler, S.5    Heinrich, D.6
  • 199
    • 65249123159 scopus 로고    scopus 로고
    • Antivascular actions of microtubule-binding drugs
    • Schwartz EL, (2009). Antivascular actions of microtubule-binding drugs. Clin Cancer Res 15: 2594-2601.
    • (2009) Clin Cancer Res , vol.15 , pp. 2594-2601
    • Schwartz, E.L.1
  • 200
    • 45949087412 scopus 로고    scopus 로고
    • Low-dose metronomic cyclophosphamide treatment mediates ischemia-dependent K-ras mutation in colorectal carcinoma xenografts
    • Shahrzad S, Shirasawa S, Sasazuki T, Rak JW, Coomber BL, (2008). Low-dose metronomic cyclophosphamide treatment mediates ischemia-dependent K-ras mutation in colorectal carcinoma xenografts. Oncogene 27: 3729-3738.
    • (2008) Oncogene , vol.27 , pp. 3729-3738
    • Shahrzad, S.1    Shirasawa, S.2    Sasazuki, T.3    Rak, J.W.4    Coomber, B.L.5
  • 201
    • 33749005405 scopus 로고    scopus 로고
    • Therapy-induced acute recruitment of circulating endothelial progenitor cells to tumors
    • Shaked Y, Ciarrocchi A, Franco M, Lee CR, Man S, Cheung AM, et al. (2006). Therapy-induced acute recruitment of circulating endothelial progenitor cells to tumors. Science 313: 1785-1787.
    • (2006) Science , vol.313 , pp. 1785-1787
    • Shaked, Y.1    Ciarrocchi, A.2    Franco, M.3    Lee, C.R.4    Man, S.5    Cheung, A.M.6
  • 202
    • 24644447853 scopus 로고    scopus 로고
    • Enhanced radiation damage of tumor vasculature by mTOR inhibitors
    • Shinohara ET, Cao C, Niermann K, Mu Y, Zeng F, Hallahan DE, et al. (2005). Enhanced radiation damage of tumor vasculature by mTOR inhibitors. Oncogene 24: 5414-5422.
    • (2005) Oncogene , vol.24 , pp. 5414-5422
    • Shinohara, E.T.1    Cao, C.2    Niermann, K.3    Mu, Y.4    Zeng, F.5    Hallahan, D.E.6
  • 203
    • 36849013036 scopus 로고    scopus 로고
    • Bv8 regulates myeloid-cell-dependent tumour angiogenesis
    • Shojaei F, Wu X, Zhong C, Yu L, Liang XH, Yao J, et al. (2007). Bv8 regulates myeloid-cell-dependent tumour angiogenesis. Nature 450: 825-831.
    • (2007) Nature , vol.450 , pp. 825-831
    • Shojaei, F.1    Wu, X.2    Zhong, C.3    Yu, L.4    Liang, X.H.5    Yao, J.6
  • 204
    • 40649104348 scopus 로고    scopus 로고
    • Role of Bv8 in neutrophil-dependent angiogenesis in a transgenic model of cancer progression
    • Shojaei F, Singh M, Thompson JD, Ferrara N, (2008). Role of Bv8 in neutrophil-dependent angiogenesis in a transgenic model of cancer progression. Proc Natl Acad Sci U S A 105: 2640-2645.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 2640-2645
    • Shojaei, F.1    Singh, M.2    Thompson, J.D.3    Ferrara, N.4
  • 205
    • 79958717044 scopus 로고    scopus 로고
    • Sunitinib in advanced alveolar soft part sarcoma: Evidence of a direct antitumor effect
    • Stacchiotti S, Negri T, Zaffaroni N, Palassini E, Morosi C, Brich S, et al. (2011). Sunitinib in advanced alveolar soft part sarcoma: evidence of a direct antitumor effect. Ann Oncol 22: 1682-1690.
    • (2011) Ann Oncol , vol.22 , pp. 1682-1690
    • Stacchiotti, S.1    Negri, T.2    Zaffaroni, N.3    Palassini, E.4    Morosi, C.5    Brich, S.6
  • 208
    • 30344460024 scopus 로고    scopus 로고
    • AP23846, a novel and highly potent Src family kinase inhibitor, reduces vascular endothelial growth factor and interleukin-8 expression in human solid tumor cell lines and abrogates downstream angiogenic processes
    • Summy JM, Trevino JG, Lesslie DP, Baker CH, Shakespeare WC, Wang Y, et al. (2005). AP23846, a novel and highly potent Src family kinase inhibitor, reduces vascular endothelial growth factor and interleukin-8 expression in human solid tumor cell lines and abrogates downstream angiogenic processes. Mol Cancer Ther 4: 1900-1911.
    • (2005) Mol Cancer Ther , vol.4 , pp. 1900-1911
    • Summy, J.M.1    Trevino, J.G.2    Lesslie, D.P.3    Baker, C.H.4    Shakespeare, W.C.5    Wang, Y.6
  • 209
    • 0034902354 scopus 로고    scopus 로고
    • Novel proteasome inhibitor PS-341 inhibits activation of nuclear factor-kappa B, cell survival, tumor growth, and angiogenesis in squamous cell carcinoma
    • Sunwoo JB, Chen Z, Dong G, Yeh N, Crowl Bancroft C, Sausville E, et al. (2001). Novel proteasome inhibitor PS-341 inhibits activation of nuclear factor-kappa B, cell survival, tumor growth, and angiogenesis in squamous cell carcinoma. Clin Cancer Res 7: 1419-1428.
    • (2001) Clin Cancer Res , vol.7 , pp. 1419-1428
    • Sunwoo, J.B.1    Chen, Z.2    Dong, G.3    Yeh, N.4    Crowl Bancroft, C.5    Sausville, E.6
  • 210
    • 81055124256 scopus 로고    scopus 로고
    • Targeting FGFR/PDGFR/VEGFR impairs tumor growth, angiogenesis, and metastasis by effects on tumor cells, endothelial cells, and pericytes in pancreatic cancer
    • Taeger J, Moser C, Hellerbrand C, Mycielska ME, Glockzin G, Schlitt HJ, et al. (2011). Targeting FGFR/PDGFR/VEGFR impairs tumor growth, angiogenesis, and metastasis by effects on tumor cells, endothelial cells, and pericytes in pancreatic cancer. Mol Cancer Ther 10: 2157-2167.
    • (2011) Mol Cancer Ther , vol.10 , pp. 2157-2167
    • Taeger, J.1    Moser, C.2    Hellerbrand, C.3    Mycielska, M.E.4    Glockzin, G.5    Schlitt, H.J.6
  • 211
    • 25144511910 scopus 로고    scopus 로고
    • The vascular endothelial growth factor (VEGF)/VEGF receptor system and its role under physiological and pathological conditions
    • Takahashi H, Shibuya M, (2005). The vascular endothelial growth factor (VEGF)/VEGF receptor system and its role under physiological and pathological conditions. Clin Sci 109: 227-241.
    • (2005) Clin Sci , vol.109 , pp. 227-241
    • Takahashi, H.1    Shibuya, M.2
  • 212
    • 17144422889 scopus 로고    scopus 로고
    • Extracellular matrix metalloproteinase inducer stimulates tumor angiogenesis by elevating vascular endothelial cell growth factor and matrix metalloproteinases
    • Tang Y, Nakada MT, Kesavan P, McCabe F, Millar H, Rafferty P, et al. (2005). Extracellular matrix metalloproteinase inducer stimulates tumor angiogenesis by elevating vascular endothelial cell growth factor and matrix metalloproteinases. Cancer Res 65: 3193-3199.
    • (2005) Cancer Res , vol.65 , pp. 3193-3199
    • Tang, Y.1    Nakada, M.T.2    Kesavan, P.3    McCabe, F.4    Millar, H.5    Rafferty, P.6
  • 213
    • 0036829791 scopus 로고    scopus 로고
    • Roles of cell adhesion molecules in tumor angiogenesis induced by cotransplantation of cancer and endothelial cells to nude rats
    • Tei K, Kawakami-Kimura N, Taguchi O, Kumamoto K, Higashiyama S, Taniguchi N, et al. (2002). Roles of cell adhesion molecules in tumor angiogenesis induced by cotransplantation of cancer and endothelial cells to nude rats. Cancer Res 62: 6289-6296.
    • (2002) Cancer Res , vol.62 , pp. 6289-6296
    • Tei, K.1    Kawakami-Kimura, N.2    Taguchi, O.3    Kumamoto, K.4    Higashiyama, S.5    Taniguchi, N.6
  • 214
    • 0030018743 scopus 로고    scopus 로고
    • A systems approach to cancer therapy. (Antioncogenics + standard cytotoxics - >mechanism(s) of interaction)
    • Teicher BA, (1996). A systems approach to cancer therapy. (Antioncogenics + standard cytotoxics - >mechanism(s) of interaction). Cancer Metastasis Rev 15: 247-272.
    • (1996) Cancer Metastasis Rev , vol.15 , pp. 247-272
    • Teicher, B.A.1
  • 215
    • 65249183165 scopus 로고    scopus 로고
    • PDGF-C induces maturation of blood vessels in a model of glioblastoma and attenuates the response to anti-VEGF treatment
    • di Tomaso E, London N, Fuja D, Logie J, Tyrrell JA, Kamoun W, et al. (2009). PDGF-C induces maturation of blood vessels in a model of glioblastoma and attenuates the response to anti-VEGF treatment. PLoS One 4: e5123.
    • (2009) PLoS One , vol.4
    • Di Tomaso, E.1    London, N.2    Fuja, D.3    Logie, J.4    Tyrrell, J.A.5    Kamoun, W.6
  • 216
    • 84885110135 scopus 로고    scopus 로고
    • Vandetanib: A novel targeted therapy for the treatment of metastatic or locally advanced medullary thyroid cancer
    • Ton GN, Banaszynski ME, Kolesar JM, (2013). Vandetanib: a novel targeted therapy for the treatment of metastatic or locally advanced medullary thyroid cancer. Am J Health Syst Pharm 70: 849-855.
    • (2013) Am J Health Syst Pharm , vol.70 , pp. 849-855
    • Ton, G.N.1    Banaszynski, M.E.2    Kolesar, J.M.3
  • 217
    • 2542628099 scopus 로고    scopus 로고
    • Vascular normalization by vascular endothelial growth factor receptor 2 blockade induces a pressure gradient across the vasculature and improves drug penetration in tumors
    • Tong RT, Boucher Y, Kozin SV, Winkler F, Hicklin DJ, Jain RK, (2004). Vascular normalization by vascular endothelial growth factor receptor 2 blockade induces a pressure gradient across the vasculature and improves drug penetration in tumors. Cancer Res 64: 3731-3736.
    • (2004) Cancer Res , vol.64 , pp. 3731-3736
    • Tong, R.T.1    Boucher, Y.2    Kozin, S.V.3    Winkler, F.4    Hicklin, D.J.5    Jain, R.K.6
  • 219
    • 0003504049 scopus 로고    scopus 로고
    • Cyclooxygenase regulates angiogenesis induced by colon cancer cells
    • Tsujii M, Kawano S, Tsuji S, Sawaoka H, Hori M, DuBois RN, (1998). Cyclooxygenase regulates angiogenesis induced by colon cancer cells. Cell 93: 705-716.
    • (1998) Cell , vol.93 , pp. 705-716
    • Tsujii, M.1    Kawano, S.2    Tsuji, S.3    Sawaoka, H.4    Hori, M.5    Dubois, R.N.6
  • 220
    • 84863897798 scopus 로고    scopus 로고
    • Bevacizumab in combination with chemotherapy as first-line therapy in advanced gastric cancer: A biomarker evaluation from the AVAGAST randomized phase III trial
    • Van Cutsem E, de Haas S, Kang YK, Ohtsu A, Tebbutt NC, Ming Xu J, et al. (2012). Bevacizumab in combination with chemotherapy as first-line therapy in advanced gastric cancer: a biomarker evaluation from the AVAGAST randomized phase III trial. J Clin Oncol 30: 2119-2127.
    • (2012) J Clin Oncol , vol.30 , pp. 2119-2127
    • Van Cutsem, E.1    De Haas, S.2    Kang, Y.K.3    Ohtsu, A.4    Tebbutt, N.C.5    Ming Xu, J.6
  • 222
    • 78649356052 scopus 로고    scopus 로고
    • Phase II study comparing volociximab (an antiangiogenic antibody) and pegylated liposomal doxorubicin (PLD) with PLD alone in recurrent ovarian or primary peritoneal cancer
    • Vergote IB, Colombo N, Kutarska E, Del Campo J, Pippitt C, Casado A, et al. (2009). Phase II study comparing volociximab (an antiangiogenic antibody) and pegylated liposomal doxorubicin (PLD) with PLD alone in recurrent ovarian or primary peritoneal cancer. ASCO Meeting Abstracts 27 (15S): 5560.
    • (2009) ASCO Meeting Abstracts , vol.27 , Issue.15 , pp. 5560
    • Vergote, I.B.1    Colombo, N.2    Kutarska, E.3    Del Campo, J.4    Pippitt, C.5    Casado, A.6
  • 223
    • 34249294557 scopus 로고    scopus 로고
    • Possible molecular mechanisms involved in the toxicity of angiogenesis inhibition
    • Verheul HM, Pinedo HM, (2007). Possible molecular mechanisms involved in the toxicity of angiogenesis inhibition. Nat Rev Cancer 7: 475-485.
    • (2007) Nat Rev Cancer , vol.7 , pp. 475-485
    • Verheul, H.M.1    Pinedo, H.M.2
  • 224
    • 79957671402 scopus 로고    scopus 로고
    • Phase I/II trial of cilengitide with cetuximab, cisplatin and 5-fluorouracil in recurrent and/or metastatic squamous cell cancer of the head and neck: Findings of the phase i part
    • Vermorken JB, Guigay J, Mesia R, Trigo JM, Keilholz U, Kerber A, et al. (2012). Phase I/II trial of cilengitide with cetuximab, cisplatin and 5-fluorouracil in recurrent and/or metastatic squamous cell cancer of the head and neck: findings of the phase I part. Br J Cancer 104: 1691-1696.
    • (2012) Br J Cancer , vol.104 , pp. 1691-1696
    • Vermorken, J.B.1    Guigay, J.2    Mesia, R.3    Trigo, J.M.4    Keilholz, U.5    Kerber, A.6
  • 225
    • 33644830810 scopus 로고    scopus 로고
    • Validation of an anti-sphingosine-1-phosphate antibody as a potential therapeutic in reducing growth, invasion, and angiogenesis in multiple tumor lineages
    • Visentin B, Vekich JA, Sibbald BJ, Cavalli AL, Moreno KM, Matteo RG, et al. (2006). Validation of an anti-sphingosine-1-phosphate antibody as a potential therapeutic in reducing growth, invasion, and angiogenesis in multiple tumor lineages. Cancer Cell 9: 225-238.
    • (2006) Cancer Cell , vol.9 , pp. 225-238
    • Visentin, B.1    Vekich, J.A.2    Sibbald, B.J.3    Cavalli, A.L.4    Moreno, K.M.5    Matteo, R.G.6
  • 226
    • 0034904048 scopus 로고    scopus 로고
    • Molecular properties and involvement of heparanase in cancer metastasis and angiogenesis
    • Vlodavsky I, Friedmann Y, (2001). Molecular properties and involvement of heparanase in cancer metastasis and angiogenesis. J Clin Invest 108: 341-347.
    • (2001) J Clin Invest , vol.108 , pp. 341-347
    • Vlodavsky, I.1    Friedmann, Y.2
  • 227
    • 77649179672 scopus 로고    scopus 로고
    • Eicosanoids and cancer
    • Wang D, Dubois RN, (2010). Eicosanoids and cancer. Nat Rev Cancer 10: 181-193.
    • (2010) Nat Rev Cancer , vol.10 , pp. 181-193
    • Wang, D.1    Dubois, R.N.2
  • 228
    • 33645850713 scopus 로고    scopus 로고
    • CXCL1 induced by prostaglandin E2 promotes angiogenesis in colorectal cancer
    • Wang D, Wang H, Brown J, Daikoku T, Ning W, Shi Q, et al. (2006). CXCL1 induced by prostaglandin E2 promotes angiogenesis in colorectal cancer. J Exp Med 203: 941-951.
    • (2006) J Exp Med , vol.203 , pp. 941-951
    • Wang, D.1    Wang, H.2    Brown, J.3    Daikoku, T.4    Ning, W.5    Shi, Q.6
  • 229
    • 84862751803 scopus 로고    scopus 로고
    • A novel monoclonal antibody to fibroblast growth factor 2 effectively inhibits growth of hepatocellular carcinoma xenografts
    • Wang L, Park H, Chhim S, Ding Y, Jiang W, Queen C, et al. (2012). A novel monoclonal antibody to fibroblast growth factor 2 effectively inhibits growth of hepatocellular carcinoma xenografts. Mol Cancer Ther 11: 864-872.
    • (2012) Mol Cancer Ther , vol.11 , pp. 864-872
    • Wang, L.1    Park, H.2    Chhim, S.3    Ding, Y.4    Jiang, W.5    Queen, C.6
  • 230
    • 47049099431 scopus 로고    scopus 로고
    • TW-37, a small-molecule inhibitor of Bcl-2, inhibits cell growth and invasion in pancreatic cancer
    • Wang Z, Song W, Aboukameel A, Mohammad M, Wang G, Banerjee S, et al. (2008). TW-37, a small-molecule inhibitor of Bcl-2, inhibits cell growth and invasion in pancreatic cancer. Int J Cancer 123: 958-966.
    • (2008) Int J Cancer , vol.123 , pp. 958-966
    • Wang, Z.1    Song, W.2    Aboukameel, A.3    Mohammad, M.4    Wang, G.5    Banerjee, S.6
  • 231
    • 79952484658 scopus 로고    scopus 로고
    • Nanoparticulate delivery system targeted to tumor neovasculature for combined anticancer and antiangiogenesis therapy
    • Wang Z, Chui WK, Ho PC, (2011). Nanoparticulate delivery system targeted to tumor neovasculature for combined anticancer and antiangiogenesis therapy. Pharm Res 28: 585-596.
    • (2011) Pharm Res , vol.28 , pp. 585-596
    • Wang, Z.1    Chui, W.K.2    Ho, P.C.3
  • 232
    • 0037102369 scopus 로고    scopus 로고
    • ZD6474 inhibits vascular endothelial growth factor signaling, angiogenesis, and tumor growth following oral administration
    • Wedge SR, Ogilvie DJ, Dukes M, Kendrew J, Chester R, Jackson JA, et al. (2002). ZD6474 inhibits vascular endothelial growth factor signaling, angiogenesis, and tumor growth following oral administration. Cancer Res 62: 4645-4655.
    • (2002) Cancer Res , vol.62 , pp. 4645-4655
    • Wedge, S.R.1    Ogilvie, D.J.2    Dukes, M.3    Kendrew, J.4    Chester, R.5    Jackson, J.A.6
  • 233
    • 1542615084 scopus 로고    scopus 로고
    • Celecoxib inhibits vascular endothelial growth factor expression in and reduces angiogenesis and metastasis of human pancreatic cancer via suppression of Sp1 transcription factor activity
    • Wei D, Wang L, He Y, Xiong HQ, Abbruzzese JL, Xie K, (2004). Celecoxib inhibits vascular endothelial growth factor expression in and reduces angiogenesis and metastasis of human pancreatic cancer via suppression of Sp1 transcription factor activity. Cancer Res 64: 2030-2038.
    • (2004) Cancer Res , vol.64 , pp. 2030-2038
    • Wei, D.1    Wang, L.2    He, Y.3    Xiong, H.Q.4    Abbruzzese, J.L.5    Xie, K.6
  • 235
    • 84655175698 scopus 로고    scopus 로고
    • Vandetanib in patients with locally advanced or metastatic medullary thyroid cancer: A randomized, double-blind phase III trial
    • Wells SA, Jr, Robinson BG, Gagel RF, Dralle H, Fagin JA, Santoro M, et al. (2012). Vandetanib in patients with locally advanced or metastatic medullary thyroid cancer: a randomized, double-blind phase III trial. J Clin Oncol 30: 134-141.
    • (2012) J Clin Oncol , vol.30 , pp. 134-141
    • Wells, Jr.S.A.1    Robinson, B.G.2    Gagel, R.F.3    Dralle, H.4    Fagin, J.A.5    Santoro, M.6
  • 236
    • 0029876376 scopus 로고    scopus 로고
    • The degradation of human endothelial cell-derived perlecan and release of bound basic fibroblast growth factor by stromelysin, collagenase, plasmin, and heparanases
    • Whitelock JM, Murdoch AD, Iozzo RV, Underwood PA, (1996). The degradation of human endothelial cell-derived perlecan and release of bound basic fibroblast growth factor by stromelysin, collagenase, plasmin, and heparanases. J Biol Chem 271: 10079-10086.
    • (1996) J Biol Chem , vol.271 , pp. 10079-10086
    • Whitelock, J.M.1    Murdoch, A.D.2    Iozzo, R.V.3    Underwood, P.A.4
  • 237
    • 79951786110 scopus 로고    scopus 로고
    • Angiotensin receptor blockers and angiogenesis: Clinical and experimental evidence
    • Willis LM, El-Remessy AB, Somanath PR, Deremer DL, Fagan SC, (2011). Angiotensin receptor blockers and angiogenesis: clinical and experimental evidence. Clin Sci 120: 307-319.
    • (2011) Clin Sci , vol.120 , pp. 307-319
    • Willis, L.M.1    El-Remessy, A.B.2    Somanath, P.R.3    Deremer, D.L.4    Fagan, S.C.5
  • 238
    • 14644420887 scopus 로고    scopus 로고
    • Effects of nonselective cyclooxygenase inhibition with low-dose ibuprofen on tumor growth, angiogenesis, metastasis, and survival in a mouse model of colorectal cancer
    • Yao M, Zhou W, Sangha S, Albert A, Chang AJ, Liu TC, et al. (2005). Effects of nonselective cyclooxygenase inhibition with low-dose ibuprofen on tumor growth, angiogenesis, metastasis, and survival in a mouse model of colorectal cancer. Clin Cancer Res 11: 1618-1628.
    • (2005) Clin Cancer Res , vol.11 , pp. 1618-1628
    • Yao, M.1    Zhou, W.2    Sangha, S.3    Albert, A.4    Chang, A.J.5    Liu, T.C.6
  • 239
    • 64949187144 scopus 로고    scopus 로고
    • Vandetanib (ZD6474), an inhibitor of VEGFR and EGFR signalling, as a novel molecular-targeted therapy against cholangiocarcinoma
    • Yoshikawa D, Ojima H, Kokubu A, Ochiya T, Kasai S, Hirohashi S, et al. (2009). Vandetanib (ZD6474), an inhibitor of VEGFR and EGFR signalling, as a novel molecular-targeted therapy against cholangiocarcinoma. Br J Cancer 100: 1257-1266.
    • (2009) Br J Cancer , vol.100 , pp. 1257-1266
    • Yoshikawa, D.1    Ojima, H.2    Kokubu, A.3    Ochiya, T.4    Kasai, S.5    Hirohashi, S.6
  • 240
    • 78049460090 scopus 로고    scopus 로고
    • PF-03732010: A fully human monoclonal antibody against P-cadherin with antitumor and antimetastatic activity
    • Zhang CC, Yan Z, Zhang Q, Kuszpit K, Zasadny K, Qiu M, et al. (2010). PF-03732010: a fully human monoclonal antibody against P-cadherin with antitumor and antimetastatic activity. Clin Cancer Res 16: 5177-5188.
    • (2010) Clin Cancer Res , vol.16 , pp. 5177-5188
    • Zhang, C.C.1    Yan, Z.2    Zhang, Q.3    Kuszpit, K.4    Zasadny, K.5    Qiu, M.6
  • 241
    • 81055124246 scopus 로고    scopus 로고
    • A novel, selective inhibitor of fibroblast growth factor receptors that shows a potent broad spectrum of antitumor activity in several tumor xenograft models
    • Zhao G, Li W-Y, Chen D, Henry JR, Li H-Y, Chen Z, et al. (2011). A novel, selective inhibitor of fibroblast growth factor receptors that shows a potent broad spectrum of antitumor activity in several tumor xenograft models. Mol Cancer Ther 10: 2200-2210.
    • (2011) Mol Cancer Ther , vol.10 , pp. 2200-2210
    • Zhao, G.1    Li, W.-Y.2    Chen, D.3    Henry, J.R.4    Li, H.-Y.5    Chen, Z.6
  • 242
    • 78650331674 scopus 로고    scopus 로고
    • Monoclonal antibodies to fibroblast growth factor receptor 2 effectively inhibit growth of gastric tumor xenografts
    • Zhao WM, Wang L, Park H, Chhim S, Tanphanich M, Yashiro M, et al. (2010). Monoclonal antibodies to fibroblast growth factor receptor 2 effectively inhibit growth of gastric tumor xenografts. Clin Cancer Res 16: 5750-5758.
    • (2010) Clin Cancer Res , vol.16 , pp. 5750-5758
    • Zhao, W.M.1    Wang, L.2    Park, H.3    Chhim, S.4    Tanphanich, M.5    Yashiro, M.6
  • 243
    • 79959266354 scopus 로고    scopus 로고
    • M402, a novel heparan sulfate mimetic, targets multiple pathways implicated in tumor progression and metastasis
    • Zhou H, Roy S, Cochran E, Zouaoui R, Chu CL, Duffner J, et al. (2011). M402, a novel heparan sulfate mimetic, targets multiple pathways implicated in tumor progression and metastasis. PLoS One 6: e21106.
    • (2011) PLoS One , vol.6
    • Zhou, H.1    Roy, S.2    Cochran, E.3    Zouaoui, R.4    Chu, C.L.5    Duffner, J.6


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