-
1
-
-
85013312416
-
Tumor angiogenesis: therapeutic implications
-
Folkman J. Tumor angiogenesis: therapeutic implications. N Engl J Med 1971, 285:1182-1186.
-
(1971)
N Engl J Med
, vol.285
, pp. 1182-1186
-
-
Folkman, J.1
-
2
-
-
0023157363
-
Angiogenic factors
-
Folkman J., Klagsbrun M. Angiogenic factors. Science 1987, 235:442-447.
-
(1987)
Science
, vol.235
, pp. 442-447
-
-
Folkman, J.1
Klagsbrun, M.2
-
3
-
-
0031969264
-
Angiogenesis and tumor metastasis
-
Zetter B.R. Angiogenesis and tumor metastasis. Ann Rev Med 1998, 49:407-424.
-
(1998)
Ann Rev Med
, vol.49
, pp. 407-424
-
-
Zetter, B.R.1
-
4
-
-
2542628099
-
Vascular normalization by vascular endothelial growth factor receptor 2 blockade induces a pressure gradient across the vasculature and improves drug penetration in tumors
-
Tong R.T., Boucher Y., Kozin S.V., Winkler F., Hicklin D.J., Jain R.K. Vascular normalization by vascular endothelial growth factor receptor 2 blockade induces a pressure gradient across the vasculature and improves drug penetration in tumors. Cancer Res 2004, 64:3731-3736.
-
(2004)
Cancer Res
, vol.64
, pp. 3731-3736
-
-
Tong, R.T.1
Boucher, Y.2
Kozin, S.V.3
Winkler, F.4
Hicklin, D.J.5
Jain, R.K.6
-
5
-
-
11844254414
-
Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy
-
Jain R.K. Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy. Science 2005, 307:58-62.
-
(2005)
Science
, vol.307
, pp. 58-62
-
-
Jain, R.K.1
-
6
-
-
0036124520
-
Abnormalities in pericytes on blood vessels and endothelial sprouts in tumors
-
Morikawa S., Baluk P., Kaidoh T., Haskell A., Jain R.K., McDonald D.M. Abnormalities in pericytes on blood vessels and endothelial sprouts in tumors. Am J Pathol 2002, 160:985-1000.
-
(2002)
Am J Pathol
, vol.160
, pp. 985-1000
-
-
Morikawa, S.1
Baluk, P.2
Kaidoh, T.3
Haskell, A.4
Jain, R.K.5
McDonald, D.M.6
-
7
-
-
26644471951
-
Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in late-stage pancreatic islet tumors
-
Casanovas O., Hicklin D.J., Bergers G., Hanahan D. Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in late-stage pancreatic islet tumors. Cancer Cell 2005, 8:299-309.
-
(2005)
Cancer Cell
, vol.8
, pp. 299-309
-
-
Casanovas, O.1
Hicklin, D.J.2
Bergers, G.3
Hanahan, D.4
-
8
-
-
0035160312
-
Impaired recruitment of bone-marrow-derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth
-
Lyden D., Hattori K., Dias S., et al. Impaired recruitment of bone-marrow-derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth. Nat Med 2001, 7:1194-1201.
-
(2001)
Nat Med
, vol.7
, pp. 1194-1201
-
-
Lyden, D.1
Hattori, K.2
Dias, S.3
-
9
-
-
33748290053
-
Incorporation of bone marrow-derived Flk-1-expressing CD34+ cells in the endothelium of tumor vessels in the mouse brain
-
Santarelli J.G., Udani V., Yung Y.C., et al. Incorporation of bone marrow-derived Flk-1-expressing CD34+ cells in the endothelium of tumor vessels in the mouse brain. Neurosurgery 2006, 59:374-382.
-
(2006)
Neurosurgery
, vol.59
, pp. 374-382
-
-
Santarelli, J.G.1
Udani, V.2
Yung, Y.C.3
-
10
-
-
0033580889
-
Vessel cooption, regression, and growth in tumors mediated by angiopoietins and VEGF
-
Holash J., Maisonpierre P.C., Compton D., et al. Vessel cooption, regression, and growth in tumors mediated by angiopoietins and VEGF. Science 1999, 284:1994-1998.
-
(1999)
Science
, vol.284
, pp. 1994-1998
-
-
Holash, J.1
Maisonpierre, P.C.2
Compton, D.3
-
11
-
-
8544249895
-
Tumor-associated endothelial cells with cytogenetic abnormalities
-
Hida K., Hida Y., Amin D.N., et al. Tumor-associated endothelial cells with cytogenetic abnormalities. Cancer Res 2004, 64:8249-8255.
-
(2004)
Cancer Res
, vol.64
, pp. 8249-8255
-
-
Hida, K.1
Hida, Y.2
Amin, D.N.3
-
12
-
-
34249822498
-
Genes that distinguish physiological and pathological angiogenesis
-
Seaman S., Stevens J., Yang M.Y., Logsdon D., Graff-Cherry C., St Croix B. Genes that distinguish physiological and pathological angiogenesis. Cancer Cell 2007, 11:539-554.
-
(2007)
Cancer Cell
, vol.11
, pp. 539-554
-
-
Seaman, S.1
Stevens, J.2
Yang, M.Y.3
Logsdon, D.4
Graff-Cherry, C.5
St Croix, B.6
-
13
-
-
47949089077
-
VEGF-targeted therapy: mechanisms of anti-tumour activity
-
Ellis L.M., Hicklin D.J. VEGF-targeted therapy: mechanisms of anti-tumour activity. Nat Rev Cancer 2008, 8:579-591.
-
(2008)
Nat Rev Cancer
, vol.8
, pp. 579-591
-
-
Ellis, L.M.1
Hicklin, D.J.2
-
14
-
-
63749125392
-
VEGFs and receptors involved in angiogenesis versus lymphangiogenesis
-
Lohela M., Bry M., Tammela T., Alitalo K. VEGFs and receptors involved in angiogenesis versus lymphangiogenesis. Curr Opin Cell Biol 2009, 21:154-165.
-
(2009)
Curr Opin Cell Biol
, vol.21
, pp. 154-165
-
-
Lohela, M.1
Bry, M.2
Tammela, T.3
Alitalo, K.4
-
15
-
-
66149086950
-
Positive and negative modulation of angiogenesis by VEGFR1 ligands
-
Cao Y. Positive and negative modulation of angiogenesis by VEGFR1 ligands. Sci Signal 2009, 2:re1.
-
(2009)
Sci Signal
, vol.2
-
-
Cao, Y.1
-
16
-
-
0034028399
-
Vegf, Vegf-B, Vegf-C and their receptors KDR, FLT-1 and FLT-4 during the neoplastic progression of human colonic mucosa
-
André T., Kotelevets L., Vaillant J.C., et al. Vegf, Vegf-B, Vegf-C and their receptors KDR, FLT-1 and FLT-4 during the neoplastic progression of human colonic mucosa. Int J Cancer 2000, 86:174-181.
-
(2000)
Int J Cancer
, vol.86
, pp. 174-181
-
-
André, T.1
Kotelevets, L.2
Vaillant, J.C.3
-
17
-
-
0032818583
-
Expression and localization of placenta growth factor and PlGF receptors in human meningiomas
-
Donnini S., Machein M.R., Plate K.H., Weich H.A. Expression and localization of placenta growth factor and PlGF receptors in human meningiomas. J Pathol 1999, 189:66-71.
-
(1999)
J Pathol
, vol.189
, pp. 66-71
-
-
Donnini, S.1
Machein, M.R.2
Plate, K.H.3
Weich, H.A.4
-
18
-
-
56749174211
-
FLT1 and its ligands VEGFB and PlGF: drug targets for anti-angiogenic therapy?
-
Fischer C., Mazzone M., Jonckx B., Carmeliet P. FLT1 and its ligands VEGFB and PlGF: drug targets for anti-angiogenic therapy?. Nat Rev Cancer 2008, 8:942-956.
-
(2008)
Nat Rev Cancer
, vol.8
, pp. 942-956
-
-
Fischer, C.1
Mazzone, M.2
Jonckx, B.3
Carmeliet, P.4
-
19
-
-
65549139264
-
VEGF-B is dispensable for blood vessel growth but critical for their survival, and VEGF-B targeting inhibits pathological angiogenesis
-
Zhang F., Tang Z., Hou X., et al. VEGF-B is dispensable for blood vessel growth but critical for their survival, and VEGF-B targeting inhibits pathological angiogenesis. Proc Natl Acad Sci USA 2009, 106:6152-6157.
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, pp. 6152-6157
-
-
Zhang, F.1
Tang, Z.2
Hou, X.3
-
20
-
-
0036306121
-
Vascular growth factors and lymphangiogenesis
-
Jussila L., Alitalo K. Vascular growth factors and lymphangiogenesis. Physiol Rev 2002, 82:673-700.
-
(2002)
Physiol Rev
, vol.82
, pp. 673-700
-
-
Jussila, L.1
Alitalo, K.2
-
21
-
-
84860120883
-
The association of alternate VEGF ligands with resistance to anti-VEGF therapy in metastatic colorectal cancer
-
Lieu CH, Tran HT, Jiang Z, et al. The association of alternate VEGF ligands with resistance to anti-VEGF therapy in metastatic colorectal cancer. J Clin Oncol 2011;29: 15(Suppl.):3533.
-
(2011)
J Clin Oncol
, vol.29
, Issue.15 SUPPL.
, pp. 3533
-
-
Lieu, C.H.1
Tran, H.T.2
Jiang, Z.3
-
22
-
-
0029959192
-
Localisation of placenta growth factor (PIGF) in human term placenta
-
Khaliq A., Li X.F., Shams M., et al. Localisation of placenta growth factor (PIGF) in human term placenta. Growth Factors 1996, 13:243-250.
-
(1996)
Growth Factors
, vol.13
, pp. 243-250
-
-
Khaliq, A.1
Li, X.F.2
Shams, M.3
-
23
-
-
0031044769
-
Expression of vascular endothelial growth factor and placenta growth factor in human placenta
-
Vuorela P., Hatva E., Lymboussaki A., et al. Expression of vascular endothelial growth factor and placenta growth factor in human placenta. Biol Reprod 1997, 56:489-494.
-
(1997)
Biol Reprod
, vol.56
, pp. 489-494
-
-
Vuorela, P.1
Hatva, E.2
Lymboussaki, A.3
-
24
-
-
0028134936
-
Placenta growth factor. Potentiation of vascular endothelial growth factor bioactivity, in vitro and in vivo, and high affinity binding to Flt-1 but not to Flk-1/KDR
-
Park J.E., Chen H.H., Winer J., Houck K.A., Ferrara N. Placenta growth factor. Potentiation of vascular endothelial growth factor bioactivity, in vitro and in vivo, and high affinity binding to Flt-1 but not to Flk-1/KDR. J Biol Chem 1994, 269:25646-25654.
-
(1994)
J Biol Chem
, vol.269
, pp. 25646-25654
-
-
Park, J.E.1
Chen, H.H.2
Winer, J.3
Houck, K.A.4
Ferrara, N.5
-
25
-
-
29244460998
-
Adenovirus-mediated gene transfer of placental growth factor to perivascular tissue induces angiogenesis via upregulation of the expression of endogenous vascular endothelial growth factor-A
-
Roy H., Bhardwaj S., Babu M., et al. Adenovirus-mediated gene transfer of placental growth factor to perivascular tissue induces angiogenesis via upregulation of the expression of endogenous vascular endothelial growth factor-A. Hum Gene Ther 2005, 16:1422-1428.
-
(2005)
Hum Gene Ther
, vol.16
, pp. 1422-1428
-
-
Roy, H.1
Bhardwaj, S.2
Babu, M.3
-
26
-
-
19244379078
-
Synergism between vascular endothelial growth factor and placental growth factor contributes to angiogenesis and plasma extravasation in pathological conditions
-
Carmeliet P., Moons L., Luttun A., et al. Synergism between vascular endothelial growth factor and placental growth factor contributes to angiogenesis and plasma extravasation in pathological conditions. Nat Med 2001, 7:575-583.
-
(2001)
Nat Med
, vol.7
, pp. 575-583
-
-
Carmeliet, P.1
Moons, L.2
Luttun, A.3
-
27
-
-
77958042477
-
Context-dependent role of angiopoietin-1 inhibition in the suppression of angiogenesis and tumor growth: implications for AMG 386, an angiopoietin-1/2-neutralizing peptibody
-
Coxon A., Bready J., Min H., et al. Context-dependent role of angiopoietin-1 inhibition in the suppression of angiogenesis and tumor growth: implications for AMG 386, an angiopoietin-1/2-neutralizing peptibody. Mol Cancer Ther 2010, 9:2641-2651.
-
(2010)
Mol Cancer Ther
, vol.9
, pp. 2641-2651
-
-
Coxon, A.1
Bready, J.2
Min, H.3
-
28
-
-
0142058307
-
The temporal-spatial expression of VEGF, angiopoietins-1 and 2, and Tie-2 during tumor angiogenesis and their functional correlation with tumor neovascular architecture
-
Tse V., Xu L., Yung Y.C., Santarelli J.G., et al. The temporal-spatial expression of VEGF, angiopoietins-1 and 2, and Tie-2 during tumor angiogenesis and their functional correlation with tumor neovascular architecture. Neurol Res 2003, 25:729-738.
-
(2003)
Neurol Res
, vol.25
, pp. 729-738
-
-
Tse, V.1
Xu, L.2
Yung, Y.C.3
Santarelli, J.G.4
-
29
-
-
22844445338
-
Comparison of the prognosis indication of VEGFR-1 and VEGFR-2 and Tie2 receptor expression in breast carcinoma
-
Meunier-Carpentier S., Dales J.P., Djemli A., et al. Comparison of the prognosis indication of VEGFR-1 and VEGFR-2 and Tie2 receptor expression in breast carcinoma. Int J Oncol 2005, 26:977-984.
-
(2005)
Int J Oncol
, vol.26
, pp. 977-984
-
-
Meunier-Carpentier, S.1
Dales, J.P.2
Djemli, A.3
-
30
-
-
14844320757
-
Expression and significance of Tie-1 and Tie-2 receptors, and angiopoietins-1, 2 and 4 in colorectal adenocarcinoma: Immunohistochemical analysis and correlation with clinicopathological factors
-
Nakayama T., Hatachi G., Wen C.Y., et al. Expression and significance of Tie-1 and Tie-2 receptors, and angiopoietins-1, 2 and 4 in colorectal adenocarcinoma: Immunohistochemical analysis and correlation with clinicopathological factors. World J Gastroenterol 2005, 11:964-969.
-
(2005)
World J Gastroenterol
, vol.11
, pp. 964-969
-
-
Nakayama, T.1
Hatachi, G.2
Wen, C.Y.3
-
31
-
-
70249114453
-
Safety, pharmacokinetics, and antitumor activity of AMG 386, a selective angiopoietin inhibitor, in adult patients with advanced solid tumors
-
Herbst R.S., Hong D., Chap L., et al. Safety, pharmacokinetics, and antitumor activity of AMG 386, a selective angiopoietin inhibitor, in adult patients with advanced solid tumors. J Clin Oncol 2009, 27:3557-3565.
-
(2009)
J Clin Oncol
, vol.27
, pp. 3557-3565
-
-
Herbst, R.S.1
Hong, D.2
Chap, L.3
-
32
-
-
77953097101
-
Phase 1 study of AMG 386, a selective angiopoietin 1/2-neutralizing peptibody, in combination with chemotherapy in adults with advanced solid tumors
-
Mita A.C., Takimoto C.H., Mita M., et al. Phase 1 study of AMG 386, a selective angiopoietin 1/2-neutralizing peptibody, in combination with chemotherapy in adults with advanced solid tumors. Clin Cancer Res 2010, 16:3044-3056.
-
(2010)
Clin Cancer Res
, vol.16
, pp. 3044-3056
-
-
Mita, A.C.1
Takimoto, C.H.2
Mita, M.3
-
33
-
-
84861196348
-
-
Avastin [package insert]. South San Francisco, CA: Genentech, Inc
-
Avastin [package insert]. South San Francisco, CA: Genentech, Inc.; 2011.
-
(2011)
-
-
-
34
-
-
84861182483
-
-
Sutent [package insert]. New York, NY: Pfizer Inc.
-
Sutent [package insert]. New York, NY: Pfizer Inc.; 2010.
-
(2010)
-
-
-
35
-
-
84861185657
-
-
Nexavar [package insert]. Wayne, NJ: Bayer AG
-
Nexavar [package insert]. Wayne, NJ: Bayer AG; 2011.
-
(2011)
-
-
-
36
-
-
84861185658
-
-
Votrient [package insert]. Research Triangle Park, NC: GlaxoSmithKline plc
-
Votrient [package insert]. Research Triangle Park, NC: GlaxoSmithKline plc; 2010.
-
(2010)
-
-
-
37
-
-
58149190795
-
Pathways mediating resistance to vascular endothelial growth factor-targeted therapy
-
Ellis L.M., Hicklin D.J. Pathways mediating resistance to vascular endothelial growth factor-targeted therapy. Clin Cancer Res 2008, 14:6371-6375.
-
(2008)
Clin Cancer Res
, vol.14
, pp. 6371-6375
-
-
Ellis, L.M.1
Hicklin, D.J.2
-
38
-
-
47949099628
-
Modes of resistance to anti-angiogenic therapy
-
Bergers G., Hanahan D. Modes of resistance to anti-angiogenic therapy. Nat Rev Cancer 2008, 8:592-603.
-
(2008)
Nat Rev Cancer
, vol.8
, pp. 592-603
-
-
Bergers, G.1
Hanahan, D.2
-
39
-
-
33846638744
-
Risks of proteinuria and hypertension with bevacizumab, an antibody against vascular endothelial growth factor: systematic review and meta-analysis
-
Zhu X., Wu S., Dahut W.L., Parikh C.R. Risks of proteinuria and hypertension with bevacizumab, an antibody against vascular endothelial growth factor: systematic review and meta-analysis. Am J Kidney Dis 2007, 49:186-193.
-
(2007)
Am J Kidney Dis
, vol.49
, pp. 186-193
-
-
Zhu, X.1
Wu, S.2
Dahut, W.L.3
Parikh, C.R.4
-
40
-
-
70349782389
-
An overview of small-molecule inhibitors of VEGFR signaling
-
Ivy S.P., Wick J.Y., Kaufman B.M. An overview of small-molecule inhibitors of VEGFR signaling. Nat Rev Clin Oncol 2009, 6:569-579.
-
(2009)
Nat Rev Clin Oncol
, vol.6
, pp. 569-579
-
-
Ivy, S.P.1
Wick, J.Y.2
Kaufman, B.M.3
-
41
-
-
0037143764
-
VEGF-Trap: a VEGF blocker with potent antitumor effects
-
Holash J., Davis S., Papadopoulos N., et al. VEGF-Trap: a VEGF blocker with potent antitumor effects. Proc Natl Acad Sci USA 2002, 99:11393-11398.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 11393-11398
-
-
Holash, J.1
Davis, S.2
Papadopoulos, N.3
-
42
-
-
74949101370
-
Phase 1 study of aflibercept administered subcutaneously to patients with advanced solid tumors
-
Tew W.P., Gordon M., Murren J., et al. Phase 1 study of aflibercept administered subcutaneously to patients with advanced solid tumors. Clin Cancer Res 2010, 16:358-366.
-
(2010)
Clin Cancer Res
, vol.16
, pp. 358-366
-
-
Tew, W.P.1
Gordon, M.2
Murren, J.3
-
43
-
-
70450175957
-
Targeting angiogenesis: progress with anti-VegF treatment with large molecules
-
Grothey A., Galanis E. Targeting angiogenesis: progress with anti-VegF treatment with large molecules. Nat Rev Clin Oncol 2009, 6:507-518.
-
(2009)
Nat Rev Clin Oncol
, vol.6
, pp. 507-518
-
-
Grothey, A.1
Galanis, E.2
-
44
-
-
36749040908
-
VEGF Trap complex formation measures production rates of VEGF, providing a biomarker for predicting efficacious angiogenic blockade
-
Rudge J.S., Holash J., Hylton D., et al. VEGF Trap complex formation measures production rates of VEGF, providing a biomarker for predicting efficacious angiogenic blockade. Proc Natl Acad Sci USA 2007, 104:18363-18370.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 18363-18370
-
-
Rudge, J.S.1
Holash, J.2
Hylton, D.3
-
45
-
-
33746442378
-
VEGF trap as a novel antiangiogenic treatment currently in clinical trials for cancer and eye diseases, and VelociGene- based discovery of the next generation of angiogenesis targets
-
Rudge J.S., Thurston G., Davis S., et al. VEGF trap as a novel antiangiogenic treatment currently in clinical trials for cancer and eye diseases, and VelociGene- based discovery of the next generation of angiogenesis targets. Cold Spring Harb Symp Quant Biol 2005, 70:411-418.
-
(2005)
Cold Spring Harb Symp Quant Biol
, vol.70
, pp. 411-418
-
-
Rudge, J.S.1
Thurston, G.2
Davis, S.3
-
46
-
-
67649921334
-
Efficacy, safety, and biomarkers of neoadjuvant bevacizumab, radiation therapy, and fluorouracil in rectal cancer: a multidisciplinary phase II study
-
Willett C.G., Duda D.G., di Tomaso E., et al. Efficacy, safety, and biomarkers of neoadjuvant bevacizumab, radiation therapy, and fluorouracil in rectal cancer: a multidisciplinary phase II study. J Clin Oncol 2009, 27:3020-3026.
-
(2009)
J Clin Oncol
, vol.27
, pp. 3020-3026
-
-
Willett, C.G.1
Duda, D.G.2
di Tomaso, E.3
-
47
-
-
49249087039
-
Antitumor activity and biomarker analysis of sunitinib in patients with bevacizumab-refractory metastatic renal cell carcinoma
-
Rini B.I., Michaelson M.D., Rosenberg J.E., et al. Antitumor activity and biomarker analysis of sunitinib in patients with bevacizumab-refractory metastatic renal cell carcinoma. J Clin Oncol 2008, 26:3743-3748.
-
(2008)
J Clin Oncol
, vol.26
, pp. 3743-3748
-
-
Rini, B.I.1
Michaelson, M.D.2
Rosenberg, J.E.3
-
48
-
-
32944466693
-
Cellular changes in normal blood capillaries undergoing regression after inhibition of VEGF signaling
-
Baffert F., Le T., Sennino B., et al. Cellular changes in normal blood capillaries undergoing regression after inhibition of VEGF signaling. Am J Physiol Heart Circ Physiol 2006, 290:H547-H559.
-
(2006)
Am J Physiol Heart Circ Physiol
, vol.290
-
-
Baffert, F.1
Le, T.2
Sennino, B.3
-
49
-
-
33748306057
-
VEGF trap abolishes shear stress- and overload-dependent angiogenesis in skeletal muscle
-
Williams J.L., Cartland D., Rudge J.S., Egginton S. VEGF trap abolishes shear stress- and overload-dependent angiogenesis in skeletal muscle. Microcirculation 2006, 13:499-509.
-
(2006)
Microcirculation
, vol.13
, pp. 499-509
-
-
Williams, J.L.1
Cartland, D.2
Rudge, J.S.3
Egginton, S.4
-
50
-
-
35148855012
-
Effects of inhibition of vascular endothelial growth factor at time of selection on follicular angiogenesis, expansion, development and atresia in the marmoset
-
Taylor P.D., Wilson H., Hillier S.G., Wiegand S.J., Fraser H.M. Effects of inhibition of vascular endothelial growth factor at time of selection on follicular angiogenesis, expansion, development and atresia in the marmoset. Mol Hum Reprod 2007, 13:729-736.
-
(2007)
Mol Hum Reprod
, vol.13
, pp. 729-736
-
-
Taylor, P.D.1
Wilson, H.2
Hillier, S.G.3
Wiegand, S.J.4
Fraser, H.M.5
-
51
-
-
50449095294
-
The role of vascular endothelial growth factor and estradiol in the regulation of endometrial angiogenesis and cell proliferation in the marmoset
-
Fraser H.M., Wilson H., Silvestri A., Morris K.D., Wiegand S.J. The role of vascular endothelial growth factor and estradiol in the regulation of endometrial angiogenesis and cell proliferation in the marmoset. Endocrinology 2008, 149:4413-4420.
-
(2008)
Endocrinology
, vol.149
, pp. 4413-4420
-
-
Fraser, H.M.1
Wilson, H.2
Silvestri, A.3
Morris, K.D.4
Wiegand, S.J.5
-
52
-
-
54049128139
-
VEGF blockade inhibits angiogenesis and reepithelialization of endometrium
-
Fan X., Krieg S., Kuo C.J., et al. VEGF blockade inhibits angiogenesis and reepithelialization of endometrium. FASEB J 2008, 22:3571-3580.
-
(2008)
FASEB J
, vol.22
, pp. 3571-3580
-
-
Fan, X.1
Krieg, S.2
Kuo, C.J.3
-
53
-
-
0037143739
-
Potent VEGF blockade causes regression of coopted vessels in a model of neuroblastoma
-
Kim E.S., Serur A., Huang J., et al. Potent VEGF blockade causes regression of coopted vessels in a model of neuroblastoma. Proc Natl Acad Sci USA 2002, 99:11399-11404.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 11399-11404
-
-
Kim, E.S.1
Serur, A.2
Huang, J.3
-
54
-
-
0037934449
-
Regression of established tumors and metastases by potent vascular endothelial growth factor blockade
-
Huang J., Frischer J.S., Serur A., et al. Regression of established tumors and metastases by potent vascular endothelial growth factor blockade. Proc Natl Acad Sci USA 2003, 100:7785-7790.
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 7785-7790
-
-
Huang, J.1
Frischer, J.S.2
Serur, A.3
-
55
-
-
0345060442
-
Vascular endothelial growth factor-trap decreases tumor burden, inhibits ascites, and causes dramatic vascular remodeling in an ovarian cancer model
-
Byrne A.T., Ross L., Holash J., et al. Vascular endothelial growth factor-trap decreases tumor burden, inhibits ascites, and causes dramatic vascular remodeling in an ovarian cancer model. Clin Cancer Res 2003, 9:5721-5728.
-
(2003)
Clin Cancer Res
, vol.9
, pp. 5721-5728
-
-
Byrne, A.T.1
Ross, L.2
Holash, J.3
-
56
-
-
2542450942
-
Vascular endothelial growth factor-trap suppresses tumorigenicity of multiple pancreatic cancer cell lines
-
Fukasawa M., Korc M. Vascular endothelial growth factor-trap suppresses tumorigenicity of multiple pancreatic cancer cell lines. Clin Cancer Res 2004, 10:3327-3332.
-
(2004)
Clin Cancer Res
, vol.10
, pp. 3327-3332
-
-
Fukasawa, M.1
Korc, M.2
-
57
-
-
34547093162
-
Vascular endothelial growth factor trap blocks tumor growth, metastasis formation, and vascular leakage in an orthotopic murine renal cell cancer model
-
Verheul H.M., Hammers H., van Erp K., et al. Vascular endothelial growth factor trap blocks tumor growth, metastasis formation, and vascular leakage in an orthotopic murine renal cell cancer model. Clin Cancer Res 2007, 13:4201-4208.
-
(2007)
Clin Cancer Res
, vol.13
, pp. 4201-4208
-
-
Verheul, H.M.1
Hammers, H.2
van Erp, K.3
-
58
-
-
85019810368
-
Multi-parametric imaging of tumor treatment response to VEGF blockade
-
May 1-7, Stockholm, Sweden. Abstract 2716.
-
Hoff BA, Bhojani MS, Rehemtulla A, Ross BD, Galban CJ. Multi-parametric imaging of tumor treatment response to VEGF blockade. In: Proceedings from the international society for magnetic resonance in medicine and European society for magnetic resonance in medicine joint annual meeting. May 1-7, 2010; Stockholm, Sweden. Abstract 2716.
-
(2010)
Proceedings from the international society for magnetic resonance in medicine and European society for magnetic resonance in medicine joint annual meeting
-
-
Hoff, B.A.1
Bhojani, M.S.2
Rehemtulla, A.3
Ross, B.D.4
Galban, C.J.5
-
59
-
-
60549106878
-
VEGF Trap induces antiglioma effect at different stages of disease
-
Gomez-Manzano C., Holash J., Fueyo J., et al. VEGF Trap induces antiglioma effect at different stages of disease. Neuro Oncol 2008, 10:940-945.
-
(2008)
Neuro Oncol
, vol.10
, pp. 940-945
-
-
Gomez-Manzano, C.1
Holash, J.2
Fueyo, J.3
-
60
-
-
3042548695
-
Inhibition of vascular endothelial growth factor (VEGF) signaling in cancer causes loss of endothelial fenestrations, regression of tumor vessels, and appearance of basement membrane ghosts
-
Inai T., Mancuso M., Hashizume H., et al. Inhibition of vascular endothelial growth factor (VEGF) signaling in cancer causes loss of endothelial fenestrations, regression of tumor vessels, and appearance of basement membrane ghosts. Am J Pathol 2004, 165:35-52.
-
(2004)
Am J Pathol
, vol.165
, pp. 35-52
-
-
Inai, T.1
Mancuso, M.2
Hashizume, H.3
-
61
-
-
84861196346
-
Rapid effects of VEGF Trap on angiogenesis and tumor cell proliferation
-
April 14-18, Los Angeles, CA. Abstract 2127.
-
Adler A, Li B, Xia A, Burakov D, Papadopoulos N, Thurston G. Rapid effects of VEGF Trap on angiogenesis and tumor cell proliferation. In: Proceedings from the 98th American association for cancer research annual meeting. April 14-18, 2007; Los Angeles, CA. Abstract 2127.
-
(2007)
Proceedings from the 98th American association for cancer research annual meeting
-
-
Adler, A.1
Li, B.2
Xia, A.3
Burakov, D.4
Papadopoulos, N.5
Thurston, G.6
-
62
-
-
84861182486
-
Identifying tumor vascular genes regulated by Aflibercept (VEGF Trap)
-
April 12-16, San Diego, CA. Abstract 2497.
-
Adler A, Eichten A, Kao C, Wei Y, Fury W, Lin C, et al. Identifying tumor vascular genes regulated by Aflibercept (VEGF Trap). In: Proceedings from the 99th American association for cancer research annual meeting. April 12-16, 2008; San Diego, CA. Abstract 2497.
-
(2008)
Proceedings from the 99th American association for cancer research annual meeting
-
-
Adler, A.1
Eichten, A.2
Kao, C.3
Wei, Y.4
Fury, W.5
Lin, C.6
-
63
-
-
78650378957
-
Effect of VEGF and VEGF Trap on vascular endothelial cell signaling in tumors
-
Lassoued W., Murphy D., Tsai J., Oueslati R., Thurston G., Lee W.M. Effect of VEGF and VEGF Trap on vascular endothelial cell signaling in tumors. Cancer Biol Ther 2011, 10:1326-1333.
-
(2011)
Cancer Biol Ther
, vol.10
, pp. 1326-1333
-
-
Lassoued, W.1
Murphy, D.2
Tsai, J.3
Oueslati, R.4
Thurston, G.5
Lee, W.M.6
-
64
-
-
57349164272
-
Specific blockade of VEGF and HER2 pathways results in greater growth inhibition of breast cancer xenografts that overexpress HER2
-
Le X.F., Mao W., Lu C., et al. Specific blockade of VEGF and HER2 pathways results in greater growth inhibition of breast cancer xenografts that overexpress HER2. Cell Cycle 2008, 7:3747-3758.
-
(2008)
Cell Cycle
, vol.7
, pp. 3747-3758
-
-
Le, X.F.1
Mao, W.2
Lu, C.3
-
65
-
-
26444484355
-
Vascular endothelial growth factor trap combined with paclitaxel strikingly inhibits tumor and ascites, prolonging survival in a human ovarian cancer model
-
Hu L., Hofmann J., Holash J., Yancopoulos G.D., Sood A.K., Jaffe R.B. Vascular endothelial growth factor trap combined with paclitaxel strikingly inhibits tumor and ascites, prolonging survival in a human ovarian cancer model. Clin Cancer Res 2005, 11(19 Pt. 1):6966-6971.
-
(2005)
Clin Cancer Res
, vol.11
, Issue.19 PART. 1
, pp. 6966-6971
-
-
Hu, L.1
Hofmann, J.2
Holash, J.3
Yancopoulos, G.D.4
Sood, A.K.5
Jaffe, R.B.6
-
66
-
-
84861185666
-
Combination of the antiangiogenic agent aflibercept results in greater antitumor activity
-
April 12-16, San Diego, CA. Abstract 1107.
-
Lejeune P, Chiron M, Le Moigne R, Vrignaud P, Bissery M-C. Combination of the antiangiogenic agent aflibercept results in greater antitumor activity. In: Proceedings from the 99th American association for cancer research annual meeting. April 12-16, 2008; San Diego, CA. Abstract 1107.
-
(2008)
Proceedings from the 99th American association for cancer research annual meeting
-
-
Lejeune, P.1
Chiron, M.2
Le Moigne, R.3
Vrignaud, P.4
Bissery, M-C.5
-
67
-
-
85019781927
-
Combination of aflibercept (VEGF Trap) and docetaxel produces increased anti-tumor effects associated with enhanced changes to tumor vasculature
-
April 17-21, Washington, DC. Abstract 5427.
-
Abrahams C, Li B, Parveen A, Thurston G. Combination of aflibercept (VEGF Trap) and docetaxel produces increased anti-tumor effects associated with enhanced changes to tumor vasculature. In: Proceedings from the 101st American association for cancer research annual meeting. April 17-21, 2010; Washington, DC. Abstract 5427.
-
(2010)
Proceedings from the 101st American association for cancer research annual meeting
-
-
Abrahams, C.1
Li, B.2
Parveen, A.3
Thurston, G.4
-
68
-
-
33947531672
-
VEGF trap in combination with radiotherapy improves tumor control in u87 glioblastoma
-
Wachsberger P.R., Burd R., Cardi C., et al. VEGF trap in combination with radiotherapy improves tumor control in u87 glioblastoma. Int J Radiat Oncol Biol Phys 2007, 67:1526-1537.
-
(2007)
Int J Radiat Oncol Biol Phys
, vol.67
, pp. 1526-1537
-
-
Wachsberger, P.R.1
Burd, R.2
Cardi, C.3
-
69
-
-
84993737605
-
Synergistic activity of aflibercept (VEGF Trap) in combination with 5-fluorouracil and irinotecan in preclinical tumor models
-
October 22-26, San Francisco, CA. Abstract A13.
-
Chiron M, Vrignaud P, Lejeune P, Demers B, Leopold D, Bissery MC. Synergistic activity of aflibercept (VEGF Trap) in combination with 5-fluorouracil and irinotecan in preclinical tumor models. In: Proceedings from the AACR-NCI-EORTC: molecular targets and cancer therapeutics. October 22-26, 2007; San Francisco, CA. Abstract A13.
-
(2007)
Proceedings from the AACR-NCI-EORTC: molecular targets and cancer therapeutics
-
-
Chiron, M.1
Vrignaud, P.2
Lejeune, P.3
Demers, B.4
Leopold, D.5
Bissery, M.C.6
-
70
-
-
77958198446
-
Aflibercept (VEGF Trap): one more double-edged sword of anti-VEGF therapy for cancer?
-
Jin K., Shen Y., He K., Xu Z., Li G., Teng L. Aflibercept (VEGF Trap): one more double-edged sword of anti-VEGF therapy for cancer?. Clin Transl Oncol 2010, 12:526-532.
-
(2010)
Clin Transl Oncol
, vol.12
, pp. 526-532
-
-
Jin, K.1
Shen, Y.2
He, K.3
Xu, Z.4
Li, G.5
Teng, L.6
-
71
-
-
2542561964
-
Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer
-
Hurwitz H., Fehrenbacher L., Novotny W., et al. Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N Engl J Med 2004, 350:2335-2342.
-
(2004)
N Engl J Med
, vol.350
, pp. 2335-2342
-
-
Hurwitz, H.1
Fehrenbacher, L.2
Novotny, W.3
-
72
-
-
33845490014
-
Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer
-
Erratum in: N Engl J Med 2007;356:318
-
Sandler A., Gray R., Perry M.C. Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer. N Engl J Med 2006, 355:2542-2550. Erratum in: N Engl J Med 2007;356:318.
-
(2006)
N Engl J Med
, vol.355
, pp. 2542-2550
-
-
Sandler, A.1
Gray, R.2
Perry, M.C.3
-
73
-
-
37549040613
-
Paclitaxel plus bevacizumab versus paclitaxel alone for metastatic breast cancer
-
Miller K., Wang M., Gralow J., et al. Paclitaxel plus bevacizumab versus paclitaxel alone for metastatic breast cancer. N Engl J Med 2007, 357:2666-2676.
-
(2007)
N Engl J Med
, vol.357
, pp. 2666-2676
-
-
Miller, K.1
Wang, M.2
Gralow, J.3
-
74
-
-
33846148701
-
Sorafenib in advanced clear-cell renal-cell carcinoma
-
Erratum in: N Engl J Med 2007;357:203
-
Escudier B., Eisen T., Stadler W.M. Sorafenib in advanced clear-cell renal-cell carcinoma. N Engl J Med 2007, 356:125-134. Erratum in: N Engl J Med 2007;357:203.
-
(2007)
N Engl J Med
, vol.356
, pp. 125-134
-
-
Escudier, B.1
Eisen, T.2
Stadler, W.M.3
-
75
-
-
33846181370
-
Sunitinib versus interferon alfa in metastatic renal-cell carcinoma
-
Motzer R.J., Hutson T.E., Tomczak P., et al. Sunitinib versus interferon alfa in metastatic renal-cell carcinoma. N Engl J Med 2007, 356:115-124.
-
(2007)
N Engl J Med
, vol.356
, pp. 115-124
-
-
Motzer, R.J.1
Hutson, T.E.2
Tomczak, P.3
-
76
-
-
0037208589
-
Phase II, randomized trial comparing bevacizumab plus fluorouracil (FU)/leucovorin (LV) with FU/LV alone in patients with metastatic colorectal cancer
-
Kabbinavar F., Hurwitz H.I., Fehrenbacher L., et al. Phase II, randomized trial comparing bevacizumab plus fluorouracil (FU)/leucovorin (LV) with FU/LV alone in patients with metastatic colorectal cancer. J Clin Oncol 2003, 2:60-65.
-
(2003)
J Clin Oncol
, vol.2
, pp. 60-65
-
-
Kabbinavar, F.1
Hurwitz, H.I.2
Fehrenbacher, L.3
-
77
-
-
74949119167
-
Phase I study of intravenous vascular endothelial growth factor trap, aflibercept, in patients with advanced solid tumors
-
Lockhart A.C., Rothenberg M.L., Dupont J., et al. Phase I study of intravenous vascular endothelial growth factor trap, aflibercept, in patients with advanced solid tumors. J Clin Oncol 2010, 28:207-214.
-
(2010)
J Clin Oncol
, vol.28
, pp. 207-214
-
-
Lockhart, A.C.1
Rothenberg, M.L.2
Dupont, J.3
-
78
-
-
70349330817
-
VEGF Trap-Eye for the treatment of neovascular age-related macular degeneration
-
Dixon J.A., Oliver S.C.N., Olson J.L., Mandava N. VEGF Trap-Eye for the treatment of neovascular age-related macular degeneration. Expert Opin Investig Drugs 2009, 18:1573-1580.
-
(2009)
Expert Opin Investig Drugs
, vol.18
, pp. 1573-1580
-
-
Dixon, J.A.1
Oliver, S.C.N.2
Olson, J.L.3
Mandava, N.4
-
79
-
-
77955900071
-
A pediatric phase I trial and pharmacokinetic study of aflibercept (VEGF Trap): A Children's Oncology Group Phase I Consortium study
-
[abstract 9530].
-
Park JR, Hawkins DS, Ingle M, et al. A pediatric phase I trial and pharmacokinetic study of aflibercept (VEGF Trap): A Children's Oncology Group Phase I Consortium study. J Clin Oncol 2010;28(15s) [abstract 9530].
-
(2010)
J Clin Oncol
, vol.28
, Issue.15 S
-
-
Park, J.R.1
Hawkins, D.S.2
Ingle, M.3
-
80
-
-
34548125294
-
Vascular endothelial growth factor-trap overcomes defects in dendritic cell differentiation but does not improve antigen-specific immune responses
-
Fricke I., Mirza N., Dupont J., et al. Vascular endothelial growth factor-trap overcomes defects in dendritic cell differentiation but does not improve antigen-specific immune responses. Clin Cancer Res 2007, 13:4840-4848.
-
(2007)
Clin Cancer Res
, vol.13
, pp. 4840-4848
-
-
Fricke, I.1
Mirza, N.2
Dupont, J.3
-
81
-
-
79960111080
-
Phase II study of aflibercept in recurrent malignant glioma: a North American brain tumor consortium study
-
de Groot J.F., Lamborn K.R., Chang S.M., et al. Phase II study of aflibercept in recurrent malignant glioma: a North American brain tumor consortium study. J Clin Oncol 2011, 29:2689-2695.
-
(2011)
J Clin Oncol
, vol.29
, pp. 2689-2695
-
-
de Groot, J.F.1
Lamborn, K.R.2
Chang, S.M.3
-
82
-
-
69549140332
-
Aflibercept (VEGF Trap) for advanced epithelial ovarian cancer (EOC) patients (pts) with symptomatic malignant ascites: preliminary results of a pilot study
-
[abstract 14598].
-
Colombo N, Mangili G, Mammoliti S, et al. Aflibercept (VEGF Trap) for advanced epithelial ovarian cancer (EOC) patients (pts) with symptomatic malignant ascites: preliminary results of a pilot study. J Clin Oncol 2008;26(15s) [abstract 14598].
-
(2008)
J Clin Oncol
, vol.26
, Issue.15 S
-
-
Colombo, N.1
Mangili, G.2
Mammoliti, S.3
-
83
-
-
84861185662
-
Intravenous aflibercept in advanced ovarian cancer patients with recurrent symptomatic malignant ascites: key efficacy and safety results of a phase II, randomized, double-blind, placebo-controlled study
-
October 11-14, Belgrade, Serbia.
-
Vergote I, Amant F, Advani S, et al. Intravenous aflibercept in advanced ovarian cancer patients with recurrent symptomatic malignant ascites: key efficacy and safety results of a phase II, randomized, double-blind, placebo-controlled study. In: Proceedings from the 16th international meeting of the European society for of gynecological oncology (ESGO). October 11-14, 2009; Belgrade, Serbia.
-
(2009)
Proceedings from the 16th international meeting of the European society for of gynecological oncology (ESGO)
-
-
Vergote, I.1
mant, F.2
Advani, S.3
-
84
-
-
77954428008
-
A multicenter, phase 2 study of vascular endothelial growth factor trap (Aflibercept) in platinum- and erlotinib-resistant adenocarcinoma of the lung
-
Leighl N.B., Raez L.E., Besse B., et al. A multicenter, phase 2 study of vascular endothelial growth factor trap (Aflibercept) in platinum- and erlotinib-resistant adenocarcinoma of the lung. J Thorac Oncol 2010, 5:1054-1059.
-
(2010)
J Thorac Oncol
, vol.5
, pp. 1054-1059
-
-
Leighl, N.B.1
Raez, L.E.2
Besse, B.3
-
85
-
-
77957756488
-
Phase II study of Aflibercept (VEGF-Trap) in patients with recurrent or metastatic urothelial cancer, a California Cancer Consortium Trial
-
Twardowski P., Stadler W.M., Frankel P., et al. Phase II study of Aflibercept (VEGF-Trap) in patients with recurrent or metastatic urothelial cancer, a California Cancer Consortium Trial. Urology 2010, 76:923-926.
-
(2010)
Urology
, vol.76
, pp. 923-926
-
-
Twardowski, P.1
Stadler, W.M.2
Frankel, P.3
-
86
-
-
79960406166
-
Myeloid biomarkers associated with glioblastoma response to anti-VEGF therapy with aflibercept
-
de Groot J.F., Piao Y., Tran H.T., et al. Myeloid biomarkers associated with glioblastoma response to anti-VEGF therapy with aflibercept. Clin Cancer Res 2011, 17:4872-4881.
-
(2011)
Clin Cancer Res
, vol.17
, pp. 4872-4881
-
-
de Groot, J.F.1
Piao, Y.2
Tran, H.T.3
-
87
-
-
84861185663
-
Sanofi-Aventis; Regeneron Pharmaceuticals
-
In: ClinicalTrials.gov [Internet]. Bethesda (MD): National Library of Medicine (US);, [cited 2011 October 7]. Available from: NLM Identifier: ctgov:NCT00327171
-
Sanofi-Aventis; Regeneron Pharmaceuticals. Study of AVE0005 (VEGF Trap) in patients With chemoresistant advanced ovarian cancer. In: ClinicalTrials.gov [Internet]. Bethesda (MD): National Library of Medicine (US); 2000 [cited 2011 October 7]. Available from: NLM Identifier: ctgov:NCT00327171.
-
(2000)
Study of AVE0005 (VEGF Trap) in patients With chemoresistant advanced ovarian cancer
-
-
-
88
-
-
36849005801
-
VEGF-Trap for patients (pts) with recurrent platinum- resistant epithelial ovarian cancer (EOC): Preliminary results of a randomized, multicenter phase II study [ASCO abstract 5508]
-
Tew WP, Colombo N, Ray-Coquard I, et al. VEGF-Trap for patients (pts) with recurrent platinum- resistant epithelial ovarian cancer (EOC): Preliminary results of a randomized, multicenter phase II study [ASCO abstract 5508]. J Clin Oncol 2007;25(18s).
-
(2007)
J Clin Oncol
, vol.25
, Issue.18 S
-
-
Tew, W.P.1
Colombo, N.2
Ray-Coquard, I.3
-
89
-
-
0023004134
-
Paracentesis of ascitic fluid. A safe procedure
-
Runyon B.A. Paracentesis of ascitic fluid. A safe procedure. Arch Intern Med 1986, 146:2259-2261.
-
(1986)
Arch Intern Med
, vol.146
, pp. 2259-2261
-
-
Runyon, B.A.1
-
90
-
-
0347377779
-
Differential inhibition of fluid accumulation and tumor growth in two mouse ascites tumors by an antivascular endothelial growth factor/permeability factor neutralizing antibody
-
Luo J.C., Toyoda M., Shibuya M. Differential inhibition of fluid accumulation and tumor growth in two mouse ascites tumors by an antivascular endothelial growth factor/permeability factor neutralizing antibody. Cancer Res 1998, 58:2594-2600.
-
(1998)
Cancer Res
, vol.58
, pp. 2594-2600
-
-
Luo, J.C.1
Toyoda, M.2
Shibuya, M.3
-
91
-
-
33748475636
-
The use of bevacizumab to palliate symptomatic ascites in patients with refractory ovarian carcinoma
-
Numnum T.M., Rocconi R.P., Whitworth J., Barnes M.N. The use of bevacizumab to palliate symptomatic ascites in patients with refractory ovarian carcinoma. Gynecol Oncol 2006, 102:425-428.
-
(2006)
Gynecol Oncol
, vol.102
, pp. 425-428
-
-
Numnum, T.M.1
Rocconi, R.P.2
Whitworth, J.3
Barnes, M.N.4
-
92
-
-
56449083663
-
Intraperitoneal bevacizumab for the palliation of malignant ascites in refractory ovarian cancer
-
Hamilton C.A., Maxwell G.L., Chernofsky M.R., Bernstein S.A., Farley J.H., Rose G.S. Intraperitoneal bevacizumab for the palliation of malignant ascites in refractory ovarian cancer. Gynecol Oncol 2008, 111:530-532.
-
(2008)
Gynecol Oncol
, vol.111
, pp. 530-532
-
-
Hamilton, C.A.1
Maxwell, G.L.2
Chernofsky, M.R.3
Bernstein, S.A.4
Farley, J.H.5
Rose, G.S.6
-
93
-
-
56449083159
-
The use of bevacizumab in refractory ovarian granulosa-cell carcinoma with symptomatic relief of ascites: a case report
-
Kesterson J.P., Mhawech-Fauceglia P., Lele S. The use of bevacizumab in refractory ovarian granulosa-cell carcinoma with symptomatic relief of ascites: a case report. Gynecol Oncol 2008, 111:527-529.
-
(2008)
Gynecol Oncol
, vol.111
, pp. 527-529
-
-
Kesterson, J.P.1
Mhawech-Fauceglia, P.2
Lele, S.3
-
94
-
-
26444484355
-
Vascular endothelial growth factor Trap combined with paclitaxel stilingly inhibits tumor and ascites, prolongs survival in a human ovarian cancer model
-
Hu L., Hofmann J., Holash J., Yancopoulos G.D., Sood A.K., Jaffe R. Vascular endothelial growth factor Trap combined with paclitaxel stilingly inhibits tumor and ascites, prolongs survival in a human ovarian cancer model. Clin Cancer Res 2005, 11:6966-6971.
-
(2005)
Clin Cancer Res
, vol.11
, pp. 6966-6971
-
-
Hu, L.1
Hofmann, J.2
Holash, J.3
Yancopoulos, G.D.4
Sood, A.K.5
Jaffe, R.6
-
95
-
-
84861185665
-
-
Sanofi-Aventis; Regeneron Pharmaceuticals, National Surgical Adjuvant Breast and Bowel Project (NSABP). Aflibercept versus placebo in combination with irinotecan and 5-FU in the treatment of patients with metastatic colorectal cancer after failure of an oxaliplatin based regimen (VELOUR). In: ClinicalTrials.gov [Internet]. Bethesda (MD): National Library of Medicine (US);, [cited 2011 October, ctgov:NCT00561470
-
Sanofi-Aventis; Regeneron Pharmaceuticals, National Surgical Adjuvant Breast and Bowel Project (NSABP). Aflibercept versus placebo in combination with irinotecan and 5-FU in the treatment of patients with metastatic colorectal cancer after failure of an oxaliplatin based regimen (VELOUR). In: ClinicalTrials.gov [Internet]. Bethesda (MD): National Library of Medicine (US); 2000 [cited 2011 October 7]. Available from: NLM Identifier: ctgov:NCT00561470.
-
(2000)
-
-
-
96
-
-
84861382251
-
Intravenous Aflibercept versus placebo in combination with irinotecan/5-FU (FOLFIRI) for second-line treatment of metastatic colorectal cancer (mCRC): results of a multinational Phase III trial (EFC10262-VELOUR)
-
[abstract O-0024].
-
Van Cutsem E, Tabernero J, Lakomy R, et al. Intravenous Aflibercept versus placebo in combination with irinotecan/5-FU (FOLFIRI) for second-line treatment of metastatic colorectal cancer (mCRC): results of a multinational Phase III trial (EFC10262-VELOUR). Ann Oncol 2011;22(s5) [abstract O-0024].
-
(2011)
Ann Oncol
, vol.22
, Issue.S5
-
-
Van Cutsem, E.1
Tabernero, J.2
Lakomy, R.3
-
97
-
-
84861185659
-
-
Sanofi-Aventis; Regeneron Pharmaceuticals. A study of aflibercept versus placebo in patients with second-line docetaxel for locally advanced or metastatic non-small-cell lung cancer (VITAL). In: ClinicalTrials.gov [Internet]. Bethesda (MD): National Library of Medicine (US);, [cited 2011 October 7]. Available from: NLM Identifier: ctgov:NCT00532155
-
Sanofi-Aventis; Regeneron Pharmaceuticals. A study of aflibercept versus placebo in patients with second-line docetaxel for locally advanced or metastatic non-small-cell lung cancer (VITAL). In: ClinicalTrials.gov [Internet]. Bethesda (MD): National Library of Medicine (US); 2000 [cited 2011 October 7]. Available from: NLM Identifier: ctgov:NCT00532155.
-
(2000)
-
-
-
98
-
-
84861185664
-
Aflibercept in combination with docetaxel for second-line treatment of locally advanced or metastatic non-small-cell lung cancer (NSCLC): Final results of a multinational placebo-controlled phase III trial (EFC10261-VITAL)
-
July 3-7, Amsterdam, The Netherlands. Abstract O43.06.
-
Novello S, Ramlay R, Gorbunova VA, et al. Aflibercept in combination with docetaxel for second-line treatment of locally advanced or metastatic non-small-cell lung cancer (NSCLC): Final results of a multinational placebo-controlled phase III trial (EFC10261-VITAL). In: Proceedings from the international association for the study of lung cancer. July 3-7, 2011; Amsterdam, The Netherlands. Abstract O43.06.
-
(2011)
Proceedings from the international association for the study of lung cancer
-
-
Novello, S.1
Ramlay, R.2
Gorbunova, V.A.3
-
99
-
-
85019778046
-
Double-blind, placebo-controlled randomized phase III trial of aflibercept (A) plus gemcitabine (G) versus placebo (P) plus gemcitabine (G) in patients with metastatic pancreatic cancer: Final results
-
June 30-July 3, Barcelona, Spain. Abstract O-0006.
-
Riess H, Manges R, Karasek P, et al. Double-blind, placebo-controlled randomized phase III trial of aflibercept (A) plus gemcitabine (G) versus placebo (P) plus gemcitabine (G) in patients with metastatic pancreatic cancer: Final results. In: Proceedings from the 12th world congress on gastrointestinal cancer. June 30-July 3, 2010; Barcelona, Spain. Abstract O-0006.
-
(2010)
Proceedings from the 12th world congress on gastrointestinal cancer
-
-
Riess, H.1
Manges, R.2
Karasek, P.3
-
100
-
-
84861196345
-
-
Sanofi-Aventis. Study of aflibercept and modified FOLFOX6 as first-line treatment in patients with metastatic colorectal cancer (AFFIRM). In: ClinicalTrials.gov [Internet]. Bethesda (MD): National Library of Medicine (US);, [cited 2011 October 7]. Available from: NLM Identifier: ctgov:NCT00851084
-
Sanofi-Aventis. Study of aflibercept and modified FOLFOX6 as first-line treatment in patients with metastatic colorectal cancer (AFFIRM). In: ClinicalTrials.gov [Internet]. Bethesda (MD): National Library of Medicine (US); 2000 [cited 2011 October 7]. Available from: NLM Identifier: ctgov:NCT00851084.
-
(2000)
-
-
-
101
-
-
84861185661
-
Sanofi-Aventis; Regeneron Pharmaceuticals
-
In: ClinicalTrials.gov [Internet]. Bethesda (MD): National Library of Medicine (US);, [cited 2011 October 7]. Available from: NLM Identifier: ctgov:NCT00519285
-
Sanofi-Aventis; Regeneron Pharmaceuticals. Aflibercept in combination with docetaxel in metastatic androgen independent prostate cancer (VENICE). In: ClinicalTrials.gov [Internet]. Bethesda (MD): National Library of Medicine (US); 2000 [cited 2011 October 7]. Available from: NLM Identifier: ctgov:NCT00519285.
-
(2000)
Aflibercept in combination with docetaxel in metastatic androgen independent prostate cancer (VENICE)
-
-
-
102
-
-
84859755855
-
A phase I study of IV aflibercept (Afl) in combination with R-CHOP in untreated patients (pts) with B-cell lymphoma
-
[abstract 8010].
-
Kuhnowski F, Thieblemont C, Jardin F, et al. A phase I study of IV aflibercept (Afl) in combination with R-CHOP in untreated patients (pts) with B-cell lymphoma. J Clin Oncol 2010;28(15s) [abstract 8010].
-
(2010)
J Clin Oncol
, vol.28
, Issue.15 S
-
-
Kuhnowski, F.1
Thieblemont, C.2
Jardin, F.3
-
103
-
-
77953667091
-
A phase I dose escalation and pharmacokinetic (PK) study of intravenous (iv) aflibercept (VEGF Trap) plus docetaxel (D) and cisplatin (C) in patients (pts) with advanced solid tumors: preliminary results
-
[abstract 14539]
-
Freyer G., Fumoleau P., You B., Isambert N., Chevalier P., Trillet-Lenoir V. A phase I dose escalation and pharmacokinetic (PK) study of intravenous (iv) aflibercept (VEGF Trap) plus docetaxel (D) and cisplatin (C) in patients (pts) with advanced solid tumors: preliminary results. J Clin Oncol 2008, 26(15s). [abstract 14539].
-
(2008)
J Clin Oncol
, vol.26
, Issue.15 S
-
-
Freyer, G.1
Fumoleau, P.2
You, B.3
Isambert, N.4
Chevalier, P.5
Trillet-Lenoir, V.6
-
104
-
-
69249228874
-
A phase I dose escalation and pharmacokinetic (PK) study of intravenous (iv) aflibercept (VEGF Trap) plus FOLFOX4 in patients (pts) with advanced solid tumors: preliminary results
-
[abstract 3556].
-
Limentani SA, Just R, Purdham A, et al. A phase I dose escalation and pharmacokinetic (PK) study of intravenous (iv) aflibercept (VEGF Trap) plus FOLFOX4 in patients (pts) with advanced solid tumors: preliminary results. J Clin Oncol 2008;26(15s) [abstract 3556].
-
(2008)
J Clin Oncol
, vol.26
, Issue.15 S
-
-
Limentani, S.A.1
Just, R.2
Purdham, A.3
-
105
-
-
69249228874
-
A phase I dose escalation and pharmacokinetic (PK) study of intravenous (iv) aflibercept (VEGF Trap) plus weekly gemcitabine (Gem) in patients (pts) with advanced solid tumors: preliminary results
-
[abstract 3558].
-
Patnaik A, Pipas M, Rosen L, et al. A phase I dose escalation and pharmacokinetic (PK) study of intravenous (iv) aflibercept (VEGF Trap) plus weekly gemcitabine (Gem) in patients (pts) with advanced solid tumors: preliminary results. J Clin Oncol 2008;26(15s) [abstract 3558].
-
(2008)
J Clin Oncol
, vol.26
, Issue.15 S
-
-
Patnaik, A.1
Pipas, M.2
Rosen, L.3
-
106
-
-
77953674924
-
A phase I dose escalation (DE) and pharmacokinetics (PK) study of intravenous aflibercept (VEGF Trap) plus irinotecan, 5-fluorouracil, and leucovorin (I-LV5FU2) in patients with advanced solid tumors (STs)
-
[abstract 3557].
-
Rixe O, Verslype C, Khayat C, et al. A phase I dose escalation (DE) and pharmacokinetics (PK) study of intravenous aflibercept (VEGF Trap) plus irinotecan, 5-fluorouracil, and leucovorin (I-LV5FU2) in patients with advanced solid tumors (STs). J Clin Oncol 2008;26(15s) [abstract 3557].
-
(2008)
J Clin Oncol
, vol.26
, Issue.15 S
-
-
Rixe, O.1
Verslype, C.2
Khayat, C.3
-
107
-
-
69249228874
-
A phase I dose escalation and pharmacokinetic (PK) study of intravenous aflibercept (VEGF trap) plus docetaxel (D) in patients (pts) with advanced solid tumors: preliminary results
-
(May 20 Suppl.) [abstract 3599].
-
Isambert N, Freyer G, Zanetta S, et al. A phase I dose escalation and pharmacokinetic (PK) study of intravenous aflibercept (VEGF trap) plus docetaxel (D) in patients (pts) with advanced solid tumors: preliminary results. J Clin Oncol 2008;26(May 20 Suppl.) [abstract 3599].
-
(2008)
J Clin Oncol
, vol.26
-
-
Isambert, N.1
Freyer, G.2
Zanetta, S.3
-
108
-
-
77957072191
-
Validation of the selected dose of aflibercept (VEGF Trap) plus irinotecan, 5-fluorouracil, and leucovorin (I-LV5FU2) in a phase I clinical trial of patients (pts) with advanced solid tumors (STs): preliminary results
-
[abstract 14540].
-
Verslype C, Spano J, Van Cutsem E, et al. Validation of the selected dose of aflibercept (VEGF Trap) plus irinotecan, 5-fluorouracil, and leucovorin (I-LV5FU2) in a phase I clinical trial of patients (pts) with advanced solid tumors (STs): preliminary results. J Clin Oncol 2008;26(15s) [abstract 14540].
-
(2008)
J Clin Oncol
, vol.26
, Issue.15 S
-
-
Verslype, C.1
Spano, J.2
Van Cutsem, E.3
-
109
-
-
84861185993
-
A phase I study of aflibercept, pemetrexed (P), and cisplatin (C) in patients with advanced solid tumors
-
[abstract 2536]
-
Townsley C.A., Siu L.L., San Pedro-Salcedo M., Liu L., Wakelee H.A. A phase I study of aflibercept, pemetrexed (P), and cisplatin (C) in patients with advanced solid tumors. J Clin Oncol 2010, 28(15s). [abstract 2536].
-
(2010)
J Clin Oncol
, vol.28
, Issue.15 S
-
-
Townsley, C.A.1
Siu, L.L.2
San Pedro-Salcedo, M.3
Liu, L.4
Wakelee, H.A.5
-
110
-
-
84858245055
-
Phase II multi-institutional study of docetaxel plus aflibercept (AVE0005, NSC# 724770) in patients with recurrent ovarian, primary peritoneal, and fallopian tube cancer
-
[abstract 5017].
-
Coleman RL, Duska LR, Ramirez PT, et al. Phase II multi-institutional study of docetaxel plus aflibercept (AVE0005, NSC# 724770) in patients with recurrent ovarian, primary peritoneal, and fallopian tube cancer. J Clin Oncol 2011;29(Suppl.) [abstract 5017].
-
(2011)
J Clin Oncol
, vol.29
, Issue.SUPPL.
-
-
Coleman, R.L.1
Duska, L.R.2
Ramirez, P.T.3
-
111
-
-
78651394951
-
A phase II study of VEGF trap (aflibercept) in patients with radioactive iodine-refractory, positron emission tomography (PET) positive thyroid carcinoma
-
[abstract 5587].
-
Sherman EJ, Ho AL, Haque S, et al. A phase II study of VEGF trap (aflibercept) in patients with radioactive iodine-refractory, positron emission tomography (PET) positive thyroid carcinoma. J Clin Oncol 2010;28(15s) [abstract 5587].
-
(2010)
J Clin Oncol
, vol.28
, Issue.15 S
-
-
Sherman, E.J.1
Ho, A.L.2
Haque, S.3
-
112
-
-
67649262706
-
Phase II trial of aflibercept (VEGF Trap) in previously treated patients with metastatic colorectal cancer (MCRC): a PMH phase II consortium trial
-
[abstract 4027]
-
Tang P., Cohen S.J., Bjarnason G.A., Kollmannsberger C., Virik K., MacKenzie M.J., et al. Phase II trial of aflibercept (VEGF Trap) in previously treated patients with metastatic colorectal cancer (MCRC): a PMH phase II consortium trial. J Clin Oncol 2008, 26(15s). [abstract 4027].
-
(2008)
J Clin Oncol
, vol.26
, Issue.15 S
-
-
Tang, P.1
Cohen, S.J.2
Bjarnason, G.A.3
Kollmannsberger, C.4
Virik, K.5
MacKenzie, M.J.6
-
113
-
-
54849433672
-
Phase II study of the efficacy and safety of intravenous (IV) AVE0005 (VEGF Trap) given every 2 weeks in patients (Pts) with platinum- and erlotinib-resistant adenocarcinoma of the lung (NSCLA)
-
[abstract 7627].
-
Massarelli E, Miller VA, Leighl N, et al. Phase II study of the efficacy and safety of intravenous (IV) AVE0005 (VEGF Trap) given every 2 weeks in patients (Pts) with platinum- and erlotinib-resistant adenocarcinoma of the lung (NSCLA). J Clin Oncol 2007;25(18s) [abstract 7627].
-
(2007)
J Clin Oncol
, vol.25
, Issue.18 S
-
-
Massarelli, E.1
Miller, V.A.2
Leighl, N.3
-
114
-
-
77950182626
-
Phase II study of aflibercept (VEGF trap) in recurrent inoperable stage III or stage IV melanoma of cutaneous or ocular origin
-
[abstract 9028].
-
Tarhini AA, Christensen S, Frankel P, et al. Phase II study of aflibercept (VEGF trap) in recurrent inoperable stage III or stage IV melanoma of cutaneous or ocular origin. J Clin Oncol 2009;27(15s) [abstract 9028].
-
(2009)
J Clin Oncol
, vol.27
, Issue.15 S
-
-
Tarhini, A.A.1
Christensen, S.2
Frankel, P.3
-
115
-
-
77957068007
-
A phase II study of aflibercept (VEGF trap) in recurrent or metastatic gynecologic soft-tissue sarcomas: A study of the Princess Margaret Hospital Phase II Consortium
-
[abstract 5591]
-
Townsley C., Hirte H., Hoskins P., Buckanovich R., Mackay H., Welch S., et al. A phase II study of aflibercept (VEGF trap) in recurrent or metastatic gynecologic soft-tissue sarcomas: A study of the Princess Margaret Hospital Phase II Consortium. J Clin Oncol 2009, 27(15s). [abstract 5591].
-
(2009)
J Clin Oncol
, vol.27
, Issue.15 S
-
-
Townsley, C.1
Hirte, H.2
Hoskins, P.3
Buckanovich, R.4
Mackay, H.5
Welch, S.6
-
116
-
-
84861185660
-
-
Eastern Cooperative Oncology Group; National Cancer Institute (NCI). VEGF Trap in treating patients with metastatic or unresectable kidney cancer. In: ClinicalTrials.gov [Internet]. Bethesda (MD): National Library of Medicine (US);, [cited 2011 October 7]. Available from: NLM Identifier: ctgov:NCT00357760
-
Eastern Cooperative Oncology Group; National Cancer Institute (NCI). VEGF Trap in treating patients with metastatic or unresectable kidney cancer. In: ClinicalTrials.gov [Internet]. Bethesda (MD): National Library of Medicine (US); 2000 [cited 2011 October 7]. Available from: NLM Identifier: ctgov:NCT00357760.
-
(2000)
-
-
-
117
-
-
84861197267
-
-
Gynecologic Oncology Group; National Cancer Institute (NCI). VEGF Trap in treating patients with recurrent or persistent endometrial cancer. In: ClinicalTrials.gov [Internet]. Bethesda (MD): National Library of Medicine (US);, [cited 2011 October 7]. Available from: NLM Identifier: ctgov:NCT00462826
-
Gynecologic Oncology Group; National Cancer Institute (NCI). VEGF Trap in treating patients with recurrent or persistent endometrial cancer. In: ClinicalTrials.gov [Internet]. Bethesda (MD): National Library of Medicine (US); 2000 [cited 2011 October 7]. Available from: NLM Identifier: ctgov:NCT00462826.
-
(2000)
-
-
-
118
-
-
84861185656
-
-
Weill Medical College of Cornell University; National Cancer Institute (NCI). VEGF Trap in treating patients with stage II or stage III multiple myeloma that has relapsed or not responded to previous treatment. In: ClinicalTrials.gov [Internet]. Bethesda (MD): National Library of Medicine (US);, [cited 2011 October 7]. Available from: NLM Identifier: ctgov:NCT00437034
-
Weill Medical College of Cornell University; National Cancer Institute (NCI). VEGF Trap in treating patients with stage II or stage III multiple myeloma that has relapsed or not responded to previous treatment. In: ClinicalTrials.gov [Internet]. Bethesda (MD): National Library of Medicine (US); 2000 [cited 2011 October 7]. Available from: NLM Identifier: ctgov:NCT00437034.
-
(2000)
-
-
-
119
-
-
84861185655
-
-
California Cancer Consortium; National Cancer Institute (NCI), Aflibercept in treating patients with myelodysplastic syndromes. In: ClinicalTrials.gov [Internet]. Bethesda (MD): National Library of Medicine (US);, [cited 2011 October 7]. Available from: NLM Identifier: ctgov:NCT00509249
-
California Cancer Consortium; National Cancer Institute (NCI), Aflibercept in treating patients with myelodysplastic syndromes. In: ClinicalTrials.gov [Internet]. Bethesda (MD): National Library of Medicine (US); 2000 [cited 2011 October 7]. Available from: NLM Identifier: ctgov:NCT00509249.
-
(2000)
-
-
-
120
-
-
77957083400
-
Clinical applications of VEGF-Trap (aflibercept) in cancer treatment
-
Teng L.-S., Jin D.-T., He K.-F., Zhang J., Wang H-H C.J. Clinical applications of VEGF-Trap (aflibercept) in cancer treatment. J Chin Med Assoc 2010, 73:449-456.
-
(2010)
J Chin Med Assoc
, vol.73
, pp. 449-456
-
-
Teng, L.-S.1
Jin, D.-T.2
He, K.-F.3
Zhang, J.4
Wang H-H, C.J.5
-
121
-
-
0036287302
-
Prevention of thecal angiogenesis, antral follicular growth, and ovulation in the primate by treatment with vascular endothelial growth factor Trap R1R2
-
Wulff C., Wilson H., Wiegand S.J., Rudge J.S., Fraser H.M. Prevention of thecal angiogenesis, antral follicular growth, and ovulation in the primate by treatment with vascular endothelial growth factor Trap R1R2. Endocrinology 2002, 143:2797-2807.
-
(2002)
Endocrinology
, vol.143
, pp. 2797-2807
-
-
Wulff, C.1
Wilson, H.2
Wiegand, S.J.3
Rudge, J.S.4
Fraser, H.M.5
|