-
1
-
-
1342287074
-
Novel angiogenic signaling pathways and vascular targets
-
Bicknell R, Harris AL. Novel angiogenic signaling pathways and vascular targets. Annu Rev Pharmacol Toxicol 2004;44:219-38.
-
(2004)
Annu Rev Pharmacol Toxicol
, vol.44
, pp. 219-238
-
-
Bicknell, R.1
Harris, A.L.2
-
2
-
-
14644440555
-
Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis
-
Hicklin DJ, Ellis LM. Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis. J Clin Oncol 2005;23: 1011-27.
-
(2005)
J Clin Oncol
, vol.23
, pp. 1011-1027
-
-
Hicklin, D.J.1
Ellis, L.M.2
-
3
-
-
14044271973
-
Transcriptional regulation of vascular endothelial growth factor in cancer
-
Loureiro RM, D'Amore PA. Transcriptional regulation of vascular endothelial growth factor in cancer. Cytokine Growth Factor Rev 2005; 16:77-89.
-
(2005)
Cytokine Growth Factor Rev
, vol.16
, pp. 77-89
-
-
Loureiro, R.M.1
D'Amore, P.A.2
-
4
-
-
16644395747
-
The role of VEGF in the regulation of physiological and pathological angiogenesis
-
Ferrara N. The role of VEGF in the regulation of physiological and pathological angiogenesis. EXS 2005;94:209-31.
-
(2005)
EXS
, vol.94
, pp. 209-231
-
-
Ferrara, N.1
-
5
-
-
1242269816
-
Role of lymphangiogenic factors in tumor metastasis
-
He Y, Karpanen T, Alitalo K. Role of lymphangiogenic factors in tumor metastasis. Biochim Biophys Acta 2004;1654:3-12.
-
(2004)
Biochim Biophys Acta
, vol.1654
, pp. 3-12
-
-
He, Y.1
Karpanen, T.2
Alitalo, K.3
-
6
-
-
0348049834
-
VEGF signaling: Integration and multi-tasking in endothelial cell biology
-
Zachary I. VEGF signaling: integration and multi-tasking in endothelial cell biology. Biochem Soc Trans 2003;31:1171-7.
-
(2003)
Biochem Soc Trans
, vol.31
, pp. 1171-1177
-
-
Zachary, I.1
-
7
-
-
2142759556
-
Phosphoinositide 3-kinase signaling pathways in tumor progression, invasion and angiogenesis
-
Brader S, Eccles SA. Phosphoinositide 3-kinase signaling pathways in tumor progression, invasion and angiogenesis. Tumori 2004;90:2-8.
-
(2004)
Tumori
, vol.90
, pp. 2-8
-
-
Brader, S.1
Eccles, S.A.2
-
8
-
-
0037362557
-
Role of plasminogen activator-plasmin system in tumor angiogenesis
-
Rakic JM, Maillard C, Jost M, et al. Role of plasminogen activator-plasmin system in tumor angiogenesis. Cell Mol Life Sci 2003;60:463-73.
-
(2003)
Cell Mol Life Sci
, vol.60
, pp. 463-473
-
-
Rakic, J.M.1
Maillard, C.2
Jost, M.3
-
9
-
-
24044459285
-
Matrix metalloproteinases and angiogenesis
-
Rundhaug JE. Matrix metalloproteinases and angiogenesis. J Cell Mol Med 2005;9:267-85.
-
(2005)
J Cell Mol Med
, vol.9
, pp. 267-285
-
-
Rundhaug, J.E.1
-
10
-
-
0036187615
-
The role of tumor-associated macrophages in tumor progression: Implications for new anticancer therapies
-
Bingle L, Brown NJ, Lewis CE. The role of tumor-associated macrophages in tumor progression: implications for new anticancer therapies. J Pathol 2002;196:254-65.
-
(2002)
J Pathol
, vol.196
, pp. 254-265
-
-
Bingle, L.1
Brown, N.J.2
Lewis, C.E.3
-
11
-
-
0141819958
-
The stress response: Implications for the clinical development of Hsp90 inhibitors
-
Whitesell L, Bagatell R, Falsey R. The stress response: implications for the clinical development of Hsp90 inhibitors. Curr Cancer Drug Targets 2003;3:349-58.
-
(2003)
Curr Cancer Drug Targets
, vol.3
, pp. 349-358
-
-
Whitesell, L.1
Bagatell, R.2
Falsey, R.3
-
12
-
-
1642268986
-
Hsp90 isoforms: Functions, expression and clinical importance
-
Sreedhar AS, Kalmar E, Csermely P, Shen YF. Hsp90 isoforms: functions, expression and clinical importance. FEBS Lett 2004;562: 11-5.
-
(2004)
FEBS Lett
, vol.562
, pp. 11-15
-
-
Sreedhar, A.S.1
Kalmar, E.2
Csermely, P.3
Shen, Y.F.4
-
13
-
-
0033210210
-
Grp94, an ER chaperone with protein and peptide binding properties
-
Argon Y, Simen BB. Grp94, an ER chaperone with protein and peptide binding properties. Semin Cell Dev Biol 1999;10:495-505.
-
(1999)
Semin Cell Dev Biol
, vol.10
, pp. 495-505
-
-
Argon, Y.1
Simen, B.B.2
-
14
-
-
0034603178
-
The Hsp90-related protein TRAP1 is a mitochondrial protein with distinct functional properties
-
Felts SJ, Owen BAL, Nguyen P, Trepel J, Donner DB, Toft DO. The Hsp90-related protein TRAP1 is a mitochondrial protein with distinct functional properties. J Biol Chem 2000;5:3305-12.
-
(2000)
J Biol Chem
, vol.5
, pp. 3305-3312
-
-
Felts, S.J.1
Owen, B.A.L.2
Nguyen, P.3
Trepel, J.4
Donner, D.B.5
Toft, D.O.6
-
15
-
-
4143095430
-
Altered Hsp90 function in cancer: A unique therapeutic opportunity
-
Bagatell R, Whitesell L. Altered Hsp90 function in cancer: a unique therapeutic opportunity. Mol Cancer Ther 2004;3:1021-30.
-
(2004)
Mol Cancer Ther
, vol.3
, pp. 1021-1030
-
-
Bagatell, R.1
Whitesell, L.2
-
16
-
-
0141819944
-
The clinical applications of heat shock protein inhibitors in cancer-present and future
-
Banerji U, Judson I, Workman P. The clinical applications of heat shock protein inhibitors in cancer-present and future. Curr Cancer Drug Targets 2003;3:385-90.
-
(2003)
Curr Cancer Drug Targets
, vol.3
, pp. 385-390
-
-
Banerji, U.1
Judson, I.2
Workman, P.3
-
17
-
-
0043288724
-
Heat shock protein 90 as a molecular target for cancer therapeutics
-
Isaacs JS, Xu W, Neckers L. Heat shock protein 90 as a molecular target for cancer therapeutics. Cancer Cell 2003;3:213-7.
-
(2003)
Cancer Cell
, vol.3
, pp. 213-217
-
-
Isaacs, J.S.1
Xu, W.2
Neckers, L.3
-
18
-
-
14344264703
-
Heat-shock protein 90 inhibitors as novel cancer chemotherapeutics - An update
-
Neckers L, Neckers K. Heat-shock protein 90 inhibitors as novel cancer chemotherapeutics - an update. Expert Opin Emerg Drugs 2005; 10:137-49.
-
(2005)
Expert Opin Emerg Drugs
, vol.10
, pp. 137-149
-
-
Neckers, L.1
Neckers, K.2
-
19
-
-
1542298267
-
Combinatorial attack on multistep carcinogenesis by inhibiting the Hsp90 molecular chaperone
-
Workman P. Combinatorial attack on multistep carcinogenesis by inhibiting the Hsp90 molecular chaperone. Cancer Lett 2004;206: 149-57.
-
(2004)
Cancer Lett
, vol.206
, pp. 149-157
-
-
Workman, P.1
-
20
-
-
0001069853
-
Endothelial metalloprotease-disintegrin protein (ADAM) is implicated in angiogenesis in vitro
-
Trochron T, Li H, Frankeene F, et al. Endothelial metalloprotease-disintegrin protein (ADAM) is implicated in angiogenesis in vitro. Angiogenesis 1998;2:277-85.
-
(1998)
Angiogenesis
, vol.2
, pp. 277-285
-
-
Trochron, T.1
Li, H.2
Frankeene, F.3
-
21
-
-
0024358455
-
Induction of morphologic differentiation of endothelial cells in culture
-
Lawley TJ, Kubota Y. Induction of morphologic differentiation of endothelial cells in culture. J Invest Dermatol 1989;93:59-61S.
-
(1989)
J Invest Dermatol
, vol.93
-
-
Lawley, T.J.1
Kubota, Y.2
-
22
-
-
16744368637
-
United Kingdom Coordinating Committee on Cancer Research guidelines for the welfare of animals in experimental neoplasia
-
2nd ed
-
Workman P, Twentyman P, Balkwill F, et al. United Kingdom Coordinating Committee on Cancer Research guidelines for the welfare of animals in experimental neoplasia. 2nd ed. Br J Cancer 1998;77:1-10.
-
(1998)
Br J Cancer
, vol.77
, pp. 1-10
-
-
Workman, P.1
Twentyman, P.2
Balkwill, F.3
-
23
-
-
0036466840
-
Hyaluronidase gene profiling and role of hyal-1 overexpression in an orthotopic model of prostate cancer
-
Patel S, Turner PR, Stubberfield C, et al. Hyaluronidase gene profiling and role of hyal-1 overexpression in an orthotopic model of prostate cancer. Int J Cancer 2002;97:416-24.
-
(2002)
Int J Cancer
, vol.97
, pp. 416-424
-
-
Patel, S.1
Turner, P.R.2
Stubberfield, C.3
-
24
-
-
0037313638
-
Betacellulin induces angiogenesis through activation of mitogen-activated protein kinase and phosphatidylinositol 3′-kinase in endothelial cell
-
Kim HS, Shin HS, Kwak HJ, Cho CH, Lee CO, Koh GY. Betacellulin induces angiogenesis through activation of mitogen-activated protein kinase and phosphatidylinositol 3′-kinase in endothelial cell. FASEB J 2003;17:318-20.
-
(2003)
FASEB J
, vol.17
, pp. 318-320
-
-
Kim, H.S.1
Shin, H.S.2
Kwak, H.J.3
Cho, C.H.4
Lee, C.O.5
Koh, G.Y.6
-
25
-
-
0035116241
-
Vascular endothelial growth factor family members are differentially regulated by c-erbB signaling in head and neck squamous carcinoma cells
-
O-charoenrat P, Rhys-Evans P, Modjtahedi H, Eccles SA. Vascular endothelial growth factor family members are differentially regulated by c-erbB signaling in head and neck squamous carcinoma cells. Clin Exp Metastasis 2000;18:155-61.
-
(2000)
Clin Exp Metastasis
, vol.18
, pp. 155-161
-
-
O-Charoenrat, P.1
Rhys-Evans, P.2
Modjtahedi, H.3
Eccles, S.A.4
-
26
-
-
0001223491
-
Neutralizing antibodies against epidermal growth factor and ErbB-2/neu receptor tyrosine kinases down-regulate vascular endothelial growth factor production by tumor cells in vitro and in vivo: Angiogenic implications for signal transduction therapy of solid tumors
-
Petit AM, Rak J, Hung MC, et al. Neutralizing antibodies against epidermal growth factor and ErbB-2/neu receptor tyrosine kinases down-regulate vascular endothelial growth factor production by tumor cells in vitro and in vivo: angiogenic implications for signal transduction therapy of solid tumors. Am J Pathol 1997;151:1523-30.
-
(1997)
Am J Pathol
, vol.151
, pp. 1523-1530
-
-
Petit, A.M.1
Rak, J.2
Hung, M.C.3
-
27
-
-
0037119415
-
Hsp90 regulates a von Hippel Lindau-independent hypoxia-inducible factor-1α-degradative pathway
-
Isaacs JS, Jung YJ, Mimnaugh EG, Martinez A, Cuttitta F, Neckers LM. Hsp90 regulates a von Hippel Lindau-independent hypoxia-inducible factor-1α-degradative pathway. J Biol Chem 2002;277:29936-44.
-
(2002)
J Biol Chem
, vol.277
, pp. 29936-29944
-
-
Isaacs, J.S.1
Jung, Y.J.2
Mimnaugh, E.G.3
Martinez, A.4
Cuttitta, F.5
Neckers, L.M.6
-
28
-
-
3242670482
-
Antiangiogenic properties of 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin: An orally bioavailable heat shock protein 90 modulator
-
Kaur G, Belotti D, Burger AM, et al. Antiangiogenic properties of 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin: an orally bioavailable heat shock protein 90 modulator. Clin Cancer Res 2004;10: 4813-21.
-
(2004)
Clin Cancer Res
, vol.10
, pp. 4813-4821
-
-
Kaur, G.1
Belotti, D.2
Burger, A.M.3
-
29
-
-
0141484615
-
A high-affinity conformation of Hsp90 confers tumor selectivity on Hsp90 inhibitors
-
Kamal A, Thao L, Sensintaffar J, et al. A high-affinity conformation of Hsp90 confers tumor selectivity on Hsp90 inhibitors. Nature 2003;425: 407-10.
-
(2003)
Nature
, vol.425
, pp. 407-410
-
-
Kamal, A.1
Thao, L.2
Sensintaffar, J.3
-
30
-
-
0033579175
-
DT-diaphorase expression and tumor cell sensitivity to 17-allylamino, 17-demethoxygeldanamycin, an inhibitor of heat shock protein 90
-
Kelland LR, Sharp SY, Rogers PM, Myers TG, Workman P. DT-diaphorase expression and tumor cell sensitivity to 17-allylamino, 17-demethoxygeldanamycin, an inhibitor of heat shock protein 90. J Natl Cancer Inst 1999;91:1940-9.
-
(1999)
J Natl Cancer Inst
, vol.91
, pp. 1940-1949
-
-
Kelland, L.R.1
Sharp, S.Y.2
Rogers, P.M.3
Myers, T.G.4
Workman, P.5
-
31
-
-
0033890818
-
Induction of a heat shock factor 1-dependent stress response alters the cytotoxic activity of hsp90-binding agents
-
Bagatell R, Paine-Murrieta GD, Taylor CW, et al. Induction of a heat shock factor 1-dependent stress response alters the cytotoxic activity of hsp90-binding agents. Clin Cancer Res 2000;6:3312-8.
-
(2000)
Clin Cancer Res
, vol.6
, pp. 3312-3318
-
-
Bagatell, R.1
Paine-Murrieta, G.D.2
Taylor, C.W.3
-
32
-
-
0034650543
-
The geldanamycins are potent inhibitors of the hepatocyte growth factor/scatter factor-Met-urokinase plasminogen activator-plasmin proteolytic network
-
Webb CP, Hose CD, Koochekpour S, et al. The geldanamycins are potent inhibitors of the hepatocyte growth factor/scatter factor-Met-urokinase plasminogen activator-plasmin proteolytic network. Cancer Res 2000;60:342-9.
-
(2000)
Cancer Res
, vol.60
, pp. 342-349
-
-
Webb, C.P.1
Hose, C.D.2
Koochekpour, S.3
-
33
-
-
19844368824
-
Geldanamycins exquisitely inhibit HGF/SF-mediated tumor cell invasion
-
Xie Q, Gao CF, Shinomiya N, et al. Geldanamycins exquisitely inhibit HGF/SF-mediated tumor cell invasion. Oncogene 2005;24: 3697-707.
-
(2005)
Oncogene
, vol.24
, pp. 3697-3707
-
-
Xie, Q.1
Gao, C.F.2
Shinomiya, N.3
-
34
-
-
0037416174
-
Differential regulation of cell motility and invasion by FAK
-
Hsia DA, Mitra SK, Hauck CR, et al. Differential regulation of cell motility and invasion by FAK. J Cell Biol 2003;160:753-67.
-
(2003)
J Cell Biol
, vol.160
, pp. 753-767
-
-
Hsia, D.A.1
Mitra, S.K.2
Hauck, C.R.3
-
35
-
-
0035948579
-
Biochemical signals and biological responses elicited by the focal adhesion kinase
-
Schaller MD. Biochemical signals and biological responses elicited by the focal adhesion kinase. Biochim Biophys Acta 2001;1540:1-21.
-
(2001)
Biochim Biophys Acta
, vol.1540
, pp. 1-21
-
-
Schaller, M.D.1
-
36
-
-
0032787306
-
The benzoquinone ansamycin geldanamycin stimulates the proteolytic degradation of focal adhesion kinase
-
Ochel H-J, Schulte TW, Nguyen P, Trepel J, Neckers L. The benzoquinone ansamycin geldanamycin stimulates the proteolytic degradation of focal adhesion kinase. Mol Genet Metab 1999;66:24-30.
-
(1999)
Mol Genet Metab
, vol.66
, pp. 24-30
-
-
Ochel, H.-J.1
Schulte, T.W.2
Nguyen, P.3
Trepel, J.4
Neckers, L.5
-
37
-
-
0037358192
-
3, requirement for VEGFR2-mediated activation of SAPK2/p38 and for Hsp90-dependent phosphorylation of focal adhesion kinase in endothelial cells activated by VEGF
-
3, requirement for VEGFR2-mediated activation of SAPK2/p38 and for Hsp90-dependent phosphorylation of focal adhesion kinase in endothelial cells activated by VEGF. Cell Stress Chaperones 2003;8:37-52.
-
(2003)
Cell Stress Chaperones
, vol.8
, pp. 37-52
-
-
Masson-Gadais, B.1
Houle, F.2
Laferriere, J.3
Huot, J.4
-
38
-
-
0034724736
-
Vascular endothelial growth factor-stimulated actin reorganization and migration of endothelial cells is regulated via the serine/threonine kinase Akt
-
Morales-Ruiz M, Fulton D, Sowa G, et al. Vascular endothelial growth factor-stimulated actin reorganization and migration of endothelial cells is regulated via the serine/threonine kinase Akt. Circ Res 2000; 86:892-6.
-
(2000)
Circ Res
, vol.86
, pp. 892-896
-
-
Morales-Ruiz, M.1
Fulton, D.2
Sowa, G.3
-
39
-
-
0036222784
-
Adhesion assembly, disassembly and turnover in migrating cells - Over and over and over again
-
Webb DJ, Parsons JT, Horwitz AF. Adhesion assembly, disassembly and turnover in migrating cells - over and over and over again. Nat Cell Biol 2002;4:E97-100.
-
(2002)
Nat Cell Biol
, vol.4
-
-
Webb, D.J.1
Parsons, J.T.2
Horwitz, A.F.3
-
40
-
-
0035337023
-
Matrix metalloproteinases in cancer invasion, metastasis and angiogenesis
-
Foda HD, Zucker S. Matrix metalloproteinases in cancer invasion, metastasis and angiogenesis. Drug Discov Today 2001;6:478-82.
-
(2001)
Drug Discov Today
, vol.6
, pp. 478-482
-
-
Foda, H.D.1
Zucker, S.2
-
42
-
-
0026722243
-
Hepatocyte growth factor is a potent angiogenic factor which stimulates endothelial cell motility and growth
-
Bussolino F, Di Renzo M, Ziche M, et al. Hepatocyte growth factor is a potent angiogenic factor which stimulates endothelial cell motility and growth. J Cell Biol 1992;119:629-41.
-
(1992)
J Cell Biol
, vol.119
, pp. 629-641
-
-
Bussolino, F.1
Di Renzo, M.2
Ziche, M.3
-
43
-
-
0035793546
-
Sensitivity of mature ErbB2 to geldanamycin is conferred by its kinase domain and is mediated by the chaperone protein Hsp90
-
Xu W, Mimnaugh E, Rosser MF, et al. Sensitivity of mature ErbB2 to geldanamycin is conferred by its kinase domain and is mediated by the chaperone protein Hsp90. J Biol Chem 2001;276:3702-8.
-
(2001)
J Biol Chem
, vol.276
, pp. 3702-3708
-
-
Xu, W.1
Mimnaugh, E.2
Rosser, M.F.3
-
44
-
-
4644301879
-
Regulation of vascular endothelial growth factor receptor 2-mediated phosphorylation of focal adhesion kinase by heat shock protein 90 and Src kinase activities
-
Le Boeuf F, Houle F, Huot J. Regulation of vascular endothelial growth factor receptor 2-mediated phosphorylation of focal adhesion kinase by heat shock protein 90 and Src kinase activities. J Biol Chem 2004;279: 39175-85.
-
(2004)
J Biol Chem
, vol.279
, pp. 39175-39185
-
-
Le Boeuf, F.1
Houle, F.2
Huot, J.3
-
45
-
-
21244446219
-
Heat-shock protein 90 inhibitors in antineoplastic therapy: Is it all wrapped up?
-
Isaacs JS. Heat-shock protein 90 inhibitors in antineoplastic therapy: is it all wrapped up? Expert Opin Investig Drugs 2005;14:569-89.
-
(2005)
Expert Opin Investig Drugs
, vol.14
, pp. 569-589
-
-
Isaacs, J.S.1
-
46
-
-
26444482073
-
Pharmacokinetic-pharmacodynamic relationships for the heat shock protein 90 molecular chaperone inhibitor 17-allylamino, 17-demethoxygeldanamycin in human ovarian cancer xenograft models
-
Banerji U, Walton M, Raynaud F, et al. Pharmacokinetic-pharmacodynamic relationships for the heat shock protein 90 molecular chaperone inhibitor 17-allylamino, 17-demethoxygeldanamycin in human ovarian cancer xenograft models. Clin Cancer Res 2005;11:7023-32.
-
(2005)
Clin Cancer Res
, vol.11
, pp. 7023-7032
-
-
Banerji, U.1
Walton, M.2
Raynaud, F.3
-
48
-
-
23044441106
-
Phase I pharmacokinetic and pharmacodynamic study of 17-allylamino, 17-demethoxygeldanamycin in patients with advanced malignancies
-
Banerji U, O'Donnell A, Scurr M, et al. Phase I pharmacokinetic and pharmacodynamic study of 17-allylamino, 17-demethoxygeldanamycin in patients with advanced malignancies. J Clin Oncol 2005;23: 4152-61.
-
(2005)
J Clin Oncol
, vol.23
, pp. 4152-4161
-
-
Banerji, U.1
O'Donnell, A.2
Scurr, M.3
-
49
-
-
0142027766
-
Angiogenesis impairment in Id-deficient mice cooperates with an Hsp90 inhibitor to completely suppress HER2/neu-dependent breast tumors
-
de Candia P, Solit DB, Giri D, et al. Angiogenesis impairment in Id-deficient mice cooperates with an Hsp90 inhibitor to completely suppress HER2/neu-dependent breast tumors. Proc Natl Acad Sci U S A 2003;100: 12337-42.
-
(2003)
Proc Natl Acad Sci U S A
, vol.100
, pp. 12337-12342
-
-
de Candia, P.1
Solit, D.B.2
Giri, D.3
-
50
-
-
5444246087
-
Parallels in invasion and angiogenesis provide pivotal points for therapeutic intervention
-
Eccles SA. Parallels in invasion and angiogenesis provide pivotal points for therapeutic intervention. Int J Dev Biol 2004;48:583-98.
-
(2004)
Int J Dev Biol
, vol.48
, pp. 583-598
-
-
Eccles, S.A.1
|