Phase I study of Cetuximab, Irinotecan, and Vandetanib (ZD6474) as therapy for patients with previously treated metastastic colorectal cancer

PLoS ONE

Volumn 7, Issue 6, 2012, Pages

  Meyerhardt, Jeffrey A ^a   Ancukiewicz, Marek ^b   Abrams, Thomas A ^a   Schrag, Deborah ^a   Enzinger, Peter C ^a   Chan, Jennifer A ^a   Kulke, Matthew H ^a   Wolpin, Brian M ^a   Goldstein, Michael ^c   Blaszkowsky, Lawrence ^b   Zhu, Andrew X ^b   Elliott, Meaghan ^a   Regan, Eileen ^a   Jain, Rakesh K ^b   Duda, Dan G ^b  

^a DANA FARBER CANCER INSTITUTE   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CETUXIMAB; FIBROBLAST GROWTH FACTOR 2; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; IRINOTECAN; PLACENTAL GROWTH FACTOR; STROMAL CELL DERIVED FACTOR 1ALPHA; TUMOR MARKER; TUMOR NECROSIS FACTOR ALPHA; VANDETANIB; VASCULOTROPIN; VASCULOTROPIN RECEPTOR 1; VASCULOTROPIN RECEPTOR 2; ANTINEOPLASTIC AGENT; CAMPTOTHECIN; DRUG DERIVATIVE; EPIDERMAL GROWTH FACTOR RECEPTOR; MONOCLONAL ANTIBODY; N (4 BROMO 2 FLUOROPHENYL) 6 METHOXY 7 ((1 METHYLPIPERIDIN 4 YL)METHOXY)QUINAZOLIN 4 AMINE; N-(4-BROMO-2-FLUOROPHENYL)-6-METHOXY-7-((1-METHYLPIPERIDIN-4-YL)METHOXY)QUINAZOLIN-4-AMINE; PIPERIDINE DERIVATIVE; QUINAZOLINE DERIVATIVE;

ABDOMINAL PAIN; ADULT; AGED; ALOPECIA; ANEMIA; ANGIOGENESIS; ANOREXIA; ANTIANGIOGENIC ACTIVITY; ARTICLE; CANCER PATIENT; CHEMOTHERAPY INDUCED EMESIS; CLINICAL ARTICLE; COLORECTAL CANCER; CONSTIPATION; CONTROLLED STUDY; DEHYDRATION; DIARRHEA; DRUG DOSE ESCALATION; DRUG EFFICACY; DRUG ERUPTION; DRUG FEVER; DRUG INDUCED HEADACHE; DRUG RECEPTOR BINDING; DRUG SAFETY; DRUG WITHDRAWAL; DRY SKIN; DYSPNEA; ELECTROLYTE DISTURBANCE; EYE IRRITATION; FATIGUE; FEMALE; HUMAN; HYPERTENSION; HYPOKALEMIA; HYPOMAGNESEMIA; LIVER DYSFUNCTION; LYMPHOCYTOPENIA; MALE; MAXIMUM TOLERATED DOSE; METASTASIS; MULTICENTER STUDY; NAIL; NAUSEA; NEUROPATHY; NEUTROPENIA; OVERALL SURVIVAL; PHASE 1 CLINICAL TRIAL; PROGRESSION FREE SURVIVAL; PROTEIN BLOOD LEVEL; PROTEINURIA; PRURITUS; QT PROLONGATION; SIDE EFFECT; THROMBOCYTOPENIA; TREATMENT OUTCOME; BLOOD; CLINICAL TRIAL; COLORECTAL TUMOR; COMPUTER ASSISTED TOMOGRAPHY; KAPLAN MEIER METHOD; METABOLISM; MIDDLE AGED; PATHOLOGY;

AGED; AGED, 80 AND OVER; CHEMORADIOTHERAPY; ESOPHAGEAL NEOPLASMS; HUMANS; LASERS, SEMICONDUCTOR; MALE; MIDDLE AGED; NEOPLASM RECURRENCE, LOCAL; PHOTOCHEMOTHERAPY; PHOTOSENSITIZING AGENTS; PORPHYRINS; SALVAGE THERAPY; ADULT; ANTIBODIES, MONOCLONAL; ANTINEOPLASTIC AGENTS; CAMPTOTHECIN; COLORECTAL NEOPLASMS; FEMALE; KAPLAN-MEIER ESTIMATE; MAXIMUM TOLERATED DOSE; NEOPLASM METASTASIS; PIPERIDINES; QUINAZOLINES; RECEPTOR, EPIDERMAL GROWTH FACTOR; TOMOGRAPHY, X-RAY COMPUTED; TREATMENT OUTCOME; TUMOR MARKERS, BIOLOGICAL; VASCULAR ENDOTHELIAL GROWTH FACTORS;

EID: 84862184774     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0038231     Document Type: Article

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