-
1
-
-
2542561964
-
Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer
-
Hurwitz H, Fehrenbacher L, Novotny W, et al. Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N Engl J Med 2004;350:2335-42.
-
(2004)
N Engl J Med
, vol.350
, pp. 2335-2342
-
-
Hurwitz, H.1
Fehrenbacher, L.2
Novotny, W.3
-
2
-
-
0029051439
-
Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension
-
Wang GL, Jiang BH, Rue EA, Semenza GL. Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. Proc Natl Acad Sci U S A 1995;92:5510-4.
-
(1995)
Proc Natl Acad Sci U S A
, vol.92
, pp. 5510-5514
-
-
Wang, G.L.1
Jiang, B.H.2
Rue, E.A.3
Semenza, G.L.4
-
3
-
-
0035834409
-
A conserved family of prolyl-4-hydroxylases that modify HIF
-
Bruick RK, McKnight SL. A conserved family of prolyl-4-hydroxylases that modify HIF. Science 2001; 294:1337-40.
-
(2001)
Science
, vol.294
, pp. 1337-1340
-
-
Bruick, R.K.1
McKnight, S.L.2
-
4
-
-
0036469038
-
Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch
-
Lando D, Peet DJ, Whelan DA, Gorman JJ, Whitelaw ML. Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch. Science 2002;295:858-61.
-
(2002)
Science
, vol.295
, pp. 858-861
-
-
Lando, D.1
Peet, D.J.2
Whelan, D.A.3
Gorman, J.J.4
Whitelaw, M.L.5
-
5
-
-
0032100732
-
HIF-1 α is required for solid tumor formation and embryonic vascularization
-
Ryan HE, Lo J, Johnson RS. HIF-1 α is required for solid tumor formation and embryonic vascularization. EMBO J 1998;17:3005-15.
-
(1998)
EMBO J
, vol.17
, pp. 3005-3015
-
-
Ryan, H.E.1
Lo, J.2
Johnson, R.S.3
-
6
-
-
24744438663
-
Induction of interleukin-8 preserves the angiogenic response in HIF-1α-deficient colon cancer cells
-
Mizukami Y, Jo WS, Duerr EM, et al. Induction of interleukin-8 preserves the angiogenic response in HIF-1α-deficient colon cancer cells. Nat Med 2005;11:992-7.
-
(2005)
Nat Med
, vol.11
, pp. 992-997
-
-
Mizukami, Y.1
Jo, W.S.2
Duerr, E.M.3
-
7
-
-
0037093107
-
Rescue of hypoxia-inducible factor-1α-deficient tumor growth by wild-type cells is independent of vascular endothelial growth factor
-
Hopfl G, Wenger RH, Ziegler U, et al. Rescue of hypoxia-inducible factor-1α-deficient tumor growth by wild-type cells is independent of vascular endothelial growth factor. Cancer Res 2002;62:2962-70.
-
(2002)
Cancer Res
, vol.62
, pp. 2962-2970
-
-
Hopfl, G.1
Wenger, R.H.2
Ziegler, U.3
-
8
-
-
0033870727
-
Hypoxia-inducible factor-1 α is a positive factor in solid tumor growth
-
Ryan HE, Poloni M, McNulty W, et al. Hypoxia-inducible factor-1 α is a positive factor in solid tumor growth. Cancer Res 2000;60:4010-5.
-
(2000)
Cancer Res
, vol.60
, pp. 4010-4015
-
-
Ryan, H.E.1
Poloni, M.2
McNulty, W.3
-
9
-
-
0029789568
-
Functional interference between hypoxia and dioxin signal transduction pathways: Competition for recruitment of the Arnt transcription factor
-
Gradin K, McGuire J, Wenger RH, et al. Functional interference between hypoxia and dioxin signal transduction pathways: competition for recruitment of the Arnt transcription factor. Mol Cell Biol 1996;16:5221-31.
-
(1996)
Mol Cell Biol
, vol.16
, pp. 5221-5231
-
-
Gradin, K.1
McGuire, J.2
Wenger, R.H.3
-
10
-
-
1642329821
-
Hypoxia-inducible factor-1-independent regulation of vascular endothelial growth factor by hypoxia in colon cancer
-
Mizukami Y, Li J, Zhang X, Zimmer MA, Iliopoulos O, Chung DC. Hypoxia-inducible factor-1-independent regulation of vascular endothelial growth factor by hypoxia in colon cancer. Cancer Res 2004;64:1765-72.
-
(2004)
Cancer Res
, vol.64
, pp. 1765-1772
-
-
Mizukami, Y.1
Li, J.2
Zhang, X.3
Zimmer, M.A.4
Iliopoulos, O.5
Chung, D.C.6
-
11
-
-
33744914879
-
Hypoxic Regulation of Vascular Endothelial Growth Factor through the Induction of Phosphatidylinositol 3-Kinase/Rho/ROCK and c-Myc
-
Mizukami Y, Fujiki K, Duerr EM, et al. Hypoxic Regulation of Vascular Endothelial Growth Factor through the Induction of Phosphatidylinositol 3-Kinase/Rho/ROCK and c-Myc. J Biol Chem 2006;281:13957-63.
-
(2006)
J Biol Chem
, vol.281
, pp. 13957-13963
-
-
Mizukami, Y.1
Fujiki, K.2
Duerr, E.M.3
-
12
-
-
0035882030
-
Regulation of vascular endothelial growth factor by the Wnt and K-ras pathways in colonic neoplasia
-
Zhang X, Gaspard JP, Chung DC. Regulation of vascular endothelial growth factor by the Wnt and K-ras pathways in colonic neoplasia. Cancer Res 2001;61:6050-4.
-
(2001)
Cancer Res
, vol.61
, pp. 6050-6054
-
-
Zhang, X.1
Gaspard, J.P.2
Chung, D.C.3
-
13
-
-
6344275304
-
Sp1 is involved in Akt-mediated induction of VEGF expression through an HIF-1-independent mechanism
-
Pore N, Liu S, Shu HK, et al. Sp1 is involved in Akt-mediated induction of VEGF expression through an HIF-1-independent mechanism. Mol Biol Cell 2004;15:4841-53.
-
(2004)
Mol Biol Cell
, vol.15
, pp. 4841-4853
-
-
Pore, N.1
Liu, S.2
Shu, H.K.3
-
14
-
-
33749049319
-
Hypoxia-induced upregulation of endothelial small G protein RhoA and Rho-kinase/ROCK2 inhibits eNOS expression
-
Jin HG, Yamashita H, Nagano Y, et al. Hypoxia-induced upregulation of endothelial small G protein RhoA and Rho-kinase/ROCK2 inhibits eNOS expression. Neurosci Lett 2006;408:62-7.
-
(2006)
Neurosci Lett
, vol.408
, pp. 62-67
-
-
Jin, H.G.1
Yamashita, H.2
Nagano, Y.3
-
15
-
-
0036792667
-
c-Myc is essential for vasculogenesis and angiogenesis during development and tumor progression
-
Baudino TA, McKay C, Pendeville-Samain H, et al. c-Myc is essential for vasculogenesis and angiogenesis during development and tumor progression. Genes Dev 2002;16:2530-43.
-
(2002)
Genes Dev
, vol.16
, pp. 2530-2543
-
-
Baudino, T.A.1
McKay, C.2
Pendeville-Samain, H.3
-
16
-
-
33748680731
-
The Myc-dependent angiogenic switch in tumors is mediated by interleukin 1β
-
Shchors K, Shchors E, Rostker F, Lawlor ER, Brown-Swigart L, Evan GI. The Myc-dependent angiogenic switch in tumors is mediated by interleukin 1β. Genes Dev 2006;20:2527-38.
-
(2006)
Genes Dev
, vol.20
, pp. 2527-2538
-
-
Shchors, K.1
Shchors, E.2
Rostker, F.3
Lawlor, E.R.4
Brown-Swigart, L.5
Evan, G.I.6
-
17
-
-
4644313271
-
c-Myc interacts with hypoxia to induce angiogenesis in vivo by a vascular endothelial growth factor-dependent mechanism
-
Knies-Bamforth UE, Fox SB, Poulsom R, Evan GI, Harris AL. c-Myc interacts with hypoxia to induce angiogenesis in vivo by a vascular endothelial growth factor-dependent mechanism. Cancer Res 2004;64:6563-70.
-
(2004)
Cancer Res
, vol.64
, pp. 6563-6570
-
-
Knies-Bamforth, U.E.1
Fox, S.B.2
Poulsom, R.3
Evan, G.I.4
Harris, A.L.5
-
18
-
-
0042972556
-
Ras modulates Myc activity to repress thrombospondin-1 expression and increase tumor angiogenesis
-
Watnick RS, Cheng YN, Rangarajan A, Ince TA, Weinberg RA. Ras modulates Myc activity to repress thrombospondin-1 expression and increase tumor angiogenesis. Cancer Cell 2003;3:219-31.
-
(2003)
Cancer Cell
, vol.3
, pp. 219-231
-
-
Watnick, R.S.1
Cheng, Y.N.2
Rangarajan, A.3
Ince, T.A.4
Weinberg, R.A.5
-
19
-
-
0034661990
-
Role of oxidants in NF-κ B activation and TNF-α gene transcription induced by hypoxia and endotoxin
-
Chandel NS, Trzyna WC, McClintock DS, Schumacker PT. Role of oxidants in NF-κ B activation and TNF-α gene transcription induced by hypoxia and endotoxin. J Immunol 2000;165:1013-21.
-
(2000)
J Immunol
, vol.165
, pp. 1013-1021
-
-
Chandel, N.S.1
Trzyna, W.C.2
McClintock, D.S.3
Schumacker, P.T.4
-
20
-
-
33845321931
-
Prolyl hydroxylase-1 negatively regulates IκB kinase-β, giving insight into hypoxia-induced NFκB activity
-
Cummins EP, Berra E, Comerford KM, et al. Prolyl hydroxylase-1 negatively regulates IκB kinase-β, giving insight into hypoxia-induced NFκB activity. Proc Natl Acad Sci U S A 2006;103:18154-9.
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, pp. 18154-18159
-
-
Cummins, E.P.1
Berra, E.2
Comerford, K.M.3
-
21
-
-
0033517189
-
NF-κB activation by tumour necrosis factor requires the Akt serine-threonine kinase
-
Ozes ON, Mayo LD, Gustin JA, Pfeffer SR, Pfeffer LM, Donner DB. NF-κB activation by tumour necrosis factor requires the Akt serine-threonine kinase. Nature 1999;401:82-5.
-
(1999)
Nature
, vol.401
, pp. 82-85
-
-
Ozes, O.N.1
Mayo, L.D.2
Gustin, J.A.3
Pfeffer, S.R.4
Pfeffer, L.M.5
Donner, D.B.6
-
22
-
-
0034306969
-
Blockade of nuclear factor-κB signaling inhibits angiogenesis and tumorigenicity of human ovarian cancer cells by suppressing expression of vascular endothelial growth factor and interleukin 8
-
Huang S, Robinson JB, Deguzman A, Bucana CD, Fidler IJ. Blockade of nuclear factor-κB signaling inhibits angiogenesis and tumorigenicity of human ovarian cancer cells by suppressing expression of vascular endothelial growth factor and interleukin 8. Cancer Res 2000;60:5334-9.
-
(2000)
Cancer Res
, vol.60
, pp. 5334-5339
-
-
Huang, S.1
Robinson, J.B.2
Deguzman, A.3
Bucana, C.D.4
Fidler, I.J.5
-
23
-
-
0037422205
-
Inhibition of constitutive NF-κ B activity by I κ B α M suppresses tumorigenesis
-
Fujioka S, Sclab as GM, Schmidt C, et al. Inhibition of constitutive NF-κ B activity by I κ B α M suppresses tumorigenesis. Oncogene 2003;22:1365-70.
-
(2003)
Oncogene
, vol.22
, pp. 1365-1370
-
-
Fujioka, S.1
Sclab as, G.M.2
Schmidt, C.3
-
24
-
-
0037442674
-
VEGF expression in human macrophages is NF-κB-dependent: Studies using adenoviruses expressing the endogenous NF-κB inhibitor IκBα and a kinase-defective form of the IκB kinase 2
-
Kiriakidis S, Andreakos E, Monaco C, Foxwell B, Feldmann M, Paleolog E. VEGF expression in human macrophages is NF-κB-dependent: studies using adenoviruses expressing the endogenous NF-κB inhibitor IκBα and a kinase-defective form of the IκB kinase 2. J Cell Sci 2003;116:665-74.
-
(2003)
J Cell Sci
, vol.116
, pp. 665-674
-
-
Kiriakidis, S.1
Andreakos, E.2
Monaco, C.3
Foxwell, B.4
Feldmann, M.5
Paleolog, E.6
-
25
-
-
0025999033
-
The human gene for vascular endothelial growth factor. Multiple protein forms are encoded through alternative exon splicing
-
Tischer E, Mitchell R, Hartman T, et al. The human gene for vascular endothelial growth factor. Multiple protein forms are encoded through alternative exon splicing. J Biol Chem 1991;266:11947-54.
-
(1991)
J Biol Chem
, vol.266
, pp. 11947-11954
-
-
Tischer, E.1
Mitchell, R.2
Hartman, T.3
-
26
-
-
4344660420
-
NF-κB and AP-1 connection: Mechanism of NF-κB-dependent regulation of AP-1 activity
-
Fujioka S, Niu J, Schmidt C, et al. NF-κB and AP-1 connection: mechanism of NF-κB-dependent regulation of AP-1 activity. Mol Cell Biol 2004;24:7806-19.
-
(2004)
Mol Cell Biol
, vol.24
, pp. 7806-7819
-
-
Fujioka, S.1
Niu, J.2
Schmidt, C.3
-
27
-
-
0036183640
-
The regulation of hypoxic genes by calcium involves c-Jun/AP-1, which cooperates with hypoxia-inducible factor 1 in response to hypoxia
-
Salnikow K, Kluz T, Costa M, et al. The regulation of hypoxic genes by calcium involves c-Jun/AP-1, which cooperates with hypoxia-inducible factor 1 in response to hypoxia. Mol Cell Biol 2002;22:1734-41.
-
(2002)
Mol Cell Biol
, vol.22
, pp. 1734-1741
-
-
Salnikow, K.1
Kluz, T.2
Costa, M.3
-
28
-
-
0347334750
-
IL-1β-mediated up-regulation of HIF-1α via an NFκB/COX-2 pathway identifies HIF-1 as a critical link between inflammation and oncogenesis
-
Jung YJ, Isaacs JS, Lee S, Trepel J, Neckers L. IL-1β-mediated up-regulation of HIF-1α via an NFκB/COX-2 pathway identifies HIF-1 as a critical link between inflammation and oncogenesis. FASEB J 2003;17:2115-7.
-
(2003)
FASEB J
, vol.17
, pp. 2115-2117
-
-
Jung, Y.J.1
Isaacs, J.S.2
Lee, S.3
Trepel, J.4
Neckers, L.5
-
29
-
-
34247187576
-
Reactive Oxygen Species Activate the HIF-1{α} Promoter Via a Functional NF{κ}B Site
-
Bonello S, Zahringer C, Belaiba RS, et al. Reactive Oxygen Species Activate the HIF-1{α} Promoter Via a Functional NF{κ}B Site. Arterioscler Thromb Vasc Biol 2007;27:755-61.
-
(2007)
Arterioscler Thromb Vasc Biol
, vol.27
, pp. 755-761
-
-
Bonello, S.1
Zahringer, C.2
Belaiba, R.S.3
-
30
-
-
0000391746
-
Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis
-
Bergers G, Brekken R, McMahon G, et al. Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis. Nat Cell Biol 2000;2:737-44.
-
(2000)
Nat Cell Biol
, vol.2
, pp. 737-744
-
-
Bergers, G.1
Brekken, R.2
McMahon, G.3
-
31
-
-
33744948425
-
Hypoxia regulates cross-talk between Syk and Lck leading to breast cancer progression and angiogenesis
-
Chakraborty G, Rangaswami H, Jain S, Kundu GC. Hypoxia regulates cross-talk between Syk and Lck leading to breast cancer progression and angiogenesis. J Biol Chem 2006;281:11322-31.
-
(2006)
J Biol Chem
, vol.281
, pp. 11322-11331
-
-
Chakraborty, G.1
Rangaswami, H.2
Jain, S.3
Kundu, G.C.4
-
32
-
-
7944223098
-
Ras-induced interleukin-8 expression plays a critical role in tumor growth and angiogenesis
-
Sparmann A, Bar-Sagi D. Ras-induced interleukin-8 expression plays a critical role in tumor growth and angiogenesis. Cancer Cell 2004;6:447-58.
-
(2004)
Cancer Cell
, vol.6
, pp. 447-458
-
-
Sparmann, A.1
Bar-Sagi, D.2
-
33
-
-
0842311598
-
Hypoxia-induced activation of p38 mitogen-activated protein kinase and phosphatidylinositol 3′-kinase signaling pathways contributes to expression of interleukin 8 in human ovarian carcinoma cells
-
Xu L, Pathak PS, Fukumura D. Hypoxia-induced activation of p38 mitogen-activated protein kinase and phosphatidylinositol 3′-kinase signaling pathways contributes to expression of interleukin 8 in human ovarian carcinoma cells. Clin Cancer Res 2004;10:701-7.
-
(2004)
Clin Cancer Res
, vol.10
, pp. 701-707
-
-
Xu, L.1
Pathak, P.S.2
Fukumura, D.3
-
34
-
-
0034682786
-
Reactive oxygen species generated at mitochondrial complex III stabilize hypoxia-inducible factor-1α during hypoxia: A mechanism of O2 sensing
-
Chandel NS, McClintock DS, Feliciano CE, et al. Reactive oxygen species generated at mitochondrial complex III stabilize hypoxia-inducible factor-1α during hypoxia: a mechanism of O2 sensing. J Biol Chem 2000;275:25130-8.
-
(2000)
J Biol Chem
, vol.275
, pp. 25130-25138
-
-
Chandel, N.S.1
McClintock, D.S.2
Feliciano, C.E.3
-
35
-
-
0035027828
-
Transcription factor HIF-1 is a necessary mediator of the pasteur effect in mammalian cells
-
Seagroves TN, Ryan HE, Lu H, et al. Transcription factor HIF-1 is a necessary mediator of the pasteur effect in mammalian cells. Mol Cell Biol 2001;21:3436-44.
-
(2001)
Mol Cell Biol
, vol.21
, pp. 3436-3444
-
-
Seagroves, T.N.1
Ryan, H.E.2
Lu, H.3
-
36
-
-
33750619348
-
Glucose metabolism and cancer
-
Shaw RJ. Glucose metabolism and cancer. Curr Opin Cell Biol 2006;18:598-608.
-
(2006)
Curr Opin Cell Biol
, vol.18
, pp. 598-608
-
-
Shaw, R.J.1
-
37
-
-
26844516068
-
NF-κB contributes to transcription of placenta growth factor and interacts with metal responsive transcription factor-1 in hypoxic human cells
-
Cramer M, Nagy I, Murphy BJ, et al. NF-κB contributes to transcription of placenta growth factor and interacts with metal responsive transcription factor-1 in hypoxic human cells. Biol Chem 2005;386:865-72.
-
(2005)
Biol Chem
, vol.386
, pp. 865-872
-
-
Cramer, M.1
Nagy, I.2
Murphy, B.J.3
-
38
-
-
33746123520
-
Direct transcriptional up-regulation of cyclooxygenase-2 by hypoxia-inducible factor (HIF)-1 promotes colorectal tumor cell survival and enhances HIF-1 transcriptional activity during hypoxia
-
Kaidi A, Qualtrough D, Williams AC, Paraskeva C. Direct transcriptional up-regulation of cyclooxygenase-2 by hypoxia-inducible factor (HIF)-1 promotes colorectal tumor cell survival and enhances HIF-1 transcriptional activity during hypoxia. Cancer Res 2006;66:6683-91.
-
(2006)
Cancer Res
, vol.66
, pp. 6683-6691
-
-
Kaidi, A.1
Qualtrough, D.2
Williams, A.C.3
Paraskeva, C.4
-
39
-
-
0031034814
-
Hypoxia induces cyclooxygenase-2 via the NF-κB p65 transcription factor in human vascular endothelial cells
-
Schmedtje JF, Jr., Ji YS, Liu WL, DuBois RN, Runge MS. Hypoxia induces cyclooxygenase-2 via the NF-κB p65 transcription factor in human vascular endothelial cells. J Biol Chem 1997;272:601-8.
-
(1997)
J Biol Chem
, vol.272
, pp. 601-608
-
-
Schmedtje Jr., J.F.1
Ji, Y.S.2
Liu, W.L.3
DuBois, R.N.4
Runge, M.S.5
-
40
-
-
0037166271
-
Cyclooxygenase-2 is overexpressed in HER-2/neu-positive breast cancer: Evidence for involvement of AP-1 and PEA3
-
Subbaramaiah K, Norton L, Gerald W, Dannenberg AJ. Cyclooxygenase-2 is overexpressed in HER-2/neu-positive breast cancer: evidence for involvement of AP-1 and PEA3. J Biol Chem 2002;277:18649-57.
-
(2002)
J Biol Chem
, vol.277
, pp. 18649-18657
-
-
Subbaramaiah, K.1
Norton, L.2
Gerald, W.3
Dannenberg, A.J.4
-
41
-
-
26444564805
-
Differential regulation of cyclooxygenase 2 expression by small GTPases Ras, Rac1, and RhoA
-
Chang YW, Putzer K, Ren L, et al. Differential regulation of cyclooxygenase 2 expression by small GTPases Ras, Rac1, and RhoA. J Cell Biochem 2005;96:314-29.
-
(2005)
J Cell Biochem
, vol.96
, pp. 314-329
-
-
Chang, Y.W.1
Putzer, K.2
Ren, L.3
-
42
-
-
0035866755
-
K-Ras-mediated increase in cyclooxygenase 2 mRNA stability involves activation of the protein kinase B1
-
Sheng H, Shao J, Dubois RN. K-Ras-mediated increase in cyclooxygenase 2 mRNA stability involves activation of the protein kinase B1. Cancer Res 2001;61:2670-5.
-
(2001)
Cancer Res
, vol.61
, pp. 2670-2675
-
-
Sheng, H.1
Shao, J.2
Dubois, R.N.3
-
43
-
-
0038375038
-
Vascular endothelial growth factor gene expression in colon cancer cells exposed to prostaglandin E2 is mediated by hypoxia-inducible factor 1
-
Fukuda R, Kelly B, Semenza GL. Vascular endothelial growth factor gene expression in colon cancer cells exposed to prostaglandin E2 is mediated by hypoxia-inducible factor 1. Cancer Res 2003;63:2330-4.
-
(2003)
Cancer Res
, vol.63
, pp. 2330-2334
-
-
Fukuda, R.1
Kelly, B.2
Semenza, G.L.3
-
44
-
-
4544320012
-
Prostaglandin E(2) promotes colorectal adenoma growth via transactivation of the nuclear peroxisome proliferator-activated receptor δ
-
Wang D, Wang H, Shi Q, et al. Prostaglandin E(2) promotes colorectal adenoma growth via transactivation of the nuclear peroxisome proliferator-activated receptor δ. Cancer Cell 2004;6:285-95.
-
(2004)
Cancer Cell
, vol.6
, pp. 285-295
-
-
Wang, D.1
Wang, H.2
Shi, Q.3
-
45
-
-
16444385003
-
Prostaglandin E2 enhances intestinal adenoma growth via activation of the Ras-mitogen-activated protein kinase cascade
-
Wang D, Buchanan FG, Wang H, Dey SK, DuBois RN. Prostaglandin E2 enhances intestinal adenoma growth via activation of the Ras-mitogen-activated protein kinase cascade. Cancer Res 2005;65:1822-9.
-
(2005)
Cancer Res
, vol.65
, pp. 1822-1829
-
-
Wang, D.1
Buchanan, F.G.2
Wang, H.3
Dey, S.K.4
DuBois, R.N.5
-
46
-
-
33645850713
-
CXCL1 induced by prostaglandin E2 promotes angiogenesis in colorectal cancer
-
Wang D, Wang H, Brown J, et al. CXCL1 induced by prostaglandin E2 promotes angiogenesis in colorectal cancer. J Exp Med 2006;203:941-51.
-
(2006)
J Exp Med
, vol.203
, pp. 941-951
-
-
Wang, D.1
Wang, H.2
Brown, J.3
-
47
-
-
1842478183
-
Hypoxic regulation of angiopoietin-2 expression in endothelial cells
-
Pichiule P, Chavez JC, LaManna JC. Hypoxic regulation of angiopoietin-2 expression in endothelial cells. J Biol Chem 2004;279:12171-80.
-
(2004)
J Biol Chem
, vol.279
, pp. 12171-12180
-
-
Pichiule, P.1
Chavez, J.C.2
LaManna, J.C.3
-
48
-
-
33749362031
-
Inhibiting hypoxia-inducible factor 1 for cancer therapy
-
Melillo G. Inhibiting hypoxia-inducible factor 1 for cancer therapy. Mol Cancer Res 2006;4:601-5.
-
(2006)
Mol Cancer Res
, vol.4
, pp. 601-605
-
-
Melillo, G.1
-
49
-
-
33646365644
-
Lysyl oxidase is essential for hypoxia-induced metastasis
-
Erler JT, Bennewith KL, Nicolau M, et al. Lysyl oxidase is essential for hypoxia-induced metastasis. Nature 2006;440:1222-6.
-
(2006)
Nature
, vol.440
, pp. 1222-1226
-
-
Erler, J.T.1
Bennewith, K.L.2
Nicolau, M.3
-
50
-
-
10044258467
-
Inhibition of vascular endothelial growth factor with a sequence-specific hypoxia response element antagonist
-
Olenyuk BZ, Zhang GJ, Klco JM, Nickols NG, Kaelin WG, Jr., Dervan PB. Inhibition of vascular endothelial growth factor with a sequence-specific hypoxia response element antagonist. Proc Natl Acad Sci U S A 2004;101:16768-73.
-
(2004)
Proc Natl Acad Sci U S A
, vol.101
, pp. 16768-16773
-
-
Olenyuk, B.Z.1
Zhang, G.J.2
Klco, J.M.3
Nickols, N.G.4
Kaelin Jr., W.G.5
Dervan, P.B.6
-
51
-
-
3142622930
-
Small molecule blockade of transcriptional coactivation of the hypoxia-inducible factor pathway
-
Kung AL, Zabludoff SD, France DS, et al. Small molecule blockade of transcriptional coactivation of the hypoxia-inducible factor pathway. Cancer Cell 2004;6:33-43.
-
(2004)
Cancer Cell
, vol.6
, pp. 33-43
-
-
Kung, A.L.1
Zabludoff, S.D.2
France, D.S.3
-
52
-
-
0036569704
-
Geldanamycin induces degradation of hypoxia-inducible factor 1α protein via the proteosome pathway in prostate cancer cells
-
Mabjeesh NJ, Post DE, Willard MT, et al. Geldanamycin induces degradation of hypoxia-inducible factor 1α protein via the proteosome pathway in prostate cancer cells. Cancer Res 2002;62:2478-82.
-
(2002)
Cancer Res
, vol.62
, pp. 2478-2482
-
-
Mabjeesh, N.J.1
Post, D.E.2
Willard, M.T.3
-
53
-
-
10744231706
-
2ME2 inhibits tumor growth and angiogenesis by disrupting microtubules and dysregulating HIF
-
Mabjeesh NJ, Escuin D, LaVallee TM, et al. 2ME2 inhibits tumor growth and angiogenesis by disrupting microtubules and dysregulating HIF. Cancer Cell 2003;3:363-75.
-
(2003)
Cancer Cell
, vol.3
, pp. 363-375
-
-
Mabjeesh, N.J.1
Escuin, D.2
LaVallee, T.M.3
-
54
-
-
26644471951
-
Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in late-stage pancreatic islet tumors
-
Casanovas O, Hicklin DJ, Bergers G, Hanahan D. Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in late-stage pancreatic islet tumors. Cancer Cell 2005;8:299-309.
-
(2005)
Cancer Cell
, vol.8
, pp. 299-309
-
-
Casanovas, O.1
Hicklin, D.J.2
Bergers, G.3
Hanahan, D.4
-
55
-
-
30944452436
-
Surrogate markers for antiangiogenic therapy and dose-limiting toxicities for bevacizumab with radiation and chemotherapy: Continued experience of a phase I trial in rectal cancer patients
-
Willett CG, Boucher Y, Duda DG, et al. Surrogate markers for antiangiogenic therapy and dose-limiting toxicities for bevacizumab with radiation and chemotherapy: continued experience of a phase I trial in rectal cancer patients. J Clin Oncol 2005;23:8136-9.
-
(2005)
J Clin Oncol
, vol.23
, pp. 8136-8139
-
-
Willett, C.G.1
Boucher, Y.2
Duda, D.G.3
|