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Volumn 83, Issue 11-12, 2007, Pages 743-751

Integrins: Signaling, disease, and therapy

Author keywords

Adhesion; Cancer; Treatment

Indexed keywords

ABCIXIMAB; ALPHA6BETA4 INTEGRIN; ALPHA7 INTEGRIN; ANTIASTHMATIC AGENT; BACTERIAL POLYSACCHARIDE; CILENGITIDE; CONTORTROSTATIN; CYCLIN D1; CYCLIN E; EFALIZUMAB; EMD 12974; ENDOSTATIN; GEMCITABINE; INTEGRIN; LOTRAFIBAN; MITOGEN ACTIVATED PROTEIN KINASE; MLN 02; MONOCLONAL ANTIBODY LM 609; NATALIZUMAB; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; RABTIVA; RESVERATROL; S 247; SB 273005; SC 55631; STRESS ACTIVATED PROTEIN KINASE; TR 14035; TRI 4035; UNCLASSIFIED DRUG; VERY LATE ACTIVATION ANTIGEN 5; VITRONECTIN RECEPTOR;

EID: 36849048720     PISSN: 09553002     EISSN: 13623095     Source Type: Journal    
DOI: 10.1080/09553000701481808     Document Type: Review
Times cited : (102)

References (100)
  • 4
    • 0033998223 scopus 로고    scopus 로고
    • In vitro and in vivo effects of a cyclic peptide with affinity for the alpha(nu)beta3 integrin in human melanoma cells
    • Allman R, Cowburn P, Mason M. 2000. In vitro and in vivo effects of a cyclic peptide with affinity for the alpha(nu)beta3 integrin in human melanoma cells. European Journal of Cancer 36:410-422.
    • (2000) European Journal of Cancer , vol.36 , pp. 410-422
    • Allman, R.1    Cowburn, P.2    Mason, M.3
  • 6
    • 0035253672 scopus 로고    scopus 로고
    • Coordinate signaling by integrins and receptor tyrosine kinases in the regulation of G1 phase cell-cycle progression
    • Assoian RK, Schwartz MA. 2001. Coordinate signaling by integrins and receptor tyrosine kinases in the regulation of G1 phase cell-cycle progression. Current Opinion in Genetics & Development 11:48-53.
    • (2001) Current Opinion in Genetics & Development , vol.11 , pp. 48-53
    • Assoian, R.K.1    Schwartz, M.A.2
  • 9
    • 0035825597 scopus 로고    scopus 로고
    • Regulation of the expression of c-Myc by beta1 integrins in epithelial cells
    • Benaud CM, Dickson RB. 2001. Regulation of the expression of c-Myc by beta1 integrins in epithelial cells. Oncogene 20:759-768.
    • (2001) Oncogene , vol.20 , pp. 759-768
    • Benaud, C.M.1    Dickson, R.B.2
  • 11
    • 0036745861 scopus 로고    scopus 로고
    • Integrins in development: Moving on, responding to, and sticking to the extracellular matrix
    • Bokel C, Brown NH. 2002. Integrins in development: Moving on, responding to, and sticking to the extracellular matrix. Developmental Cell 3:311-321.
    • (2002) Developmental Cell , vol.3 , pp. 311-321
    • Bokel, C.1    Brown, N.H.2
  • 12
    • 0032908323 scopus 로고    scopus 로고
    • Structure and function of hemidesmosomes: More than simple adhesion complexes
    • Borradori L, Sonnenberg A. 1999. Structure and function of hemidesmosomes: more than simple adhesion complexes. Journal of Investigative Dermatology 112:411-418.
    • (1999) Journal of Investigative Dermatology , vol.112 , pp. 411-418
    • Borradori, L.1    Sonnenberg, A.2
  • 14
    • 0028362876 scopus 로고
    • Requirement of vascular integrin alpha v beta 3 for angiogenesis
    • Brooks PC, Clark RA, Cheresh DA. 1994a. Requirement of vascular integrin alpha v beta 3 for angiogenesis. Science 264:569-571.
    • (1994) Science , vol.264 , pp. 569-571
    • Brooks, P.C.1    Clark, R.A.2    Cheresh, D.A.3
  • 15
    • 0028670833 scopus 로고
    • Integrin alpha v beta 3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels
    • Brooks PC, Montgomery AM, Rosenfeld M, Reisfeld RA, Hu T, Klier G, Cheresh DA. 1994b. Integrin alpha v beta 3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels. Cell 79:1157-1164.
    • (1994) Cell , vol.79 , pp. 1157-1164
    • Brooks, P.C.1    Montgomery, A.M.2    Rosenfeld, M.3    Reisfeld, R.A.4    Hu, T.5    Klier, G.6    Cheresh, D.A.7
  • 18
    • 33748616254 scopus 로고    scopus 로고
    • Anti-angiogenic cancer therapy based on integrin alphavbeta3 antagonism
    • Cai W, Chen X. 2006. Anti-angiogenic cancer therapy based on integrin alphavbeta3 antagonism. Anti-Cancer Agents in Medicinal Chemistry 6:407-428.
    • (2006) Anti-Cancer Agents in Medicinal Chemistry , vol.6 , pp. 407-428
    • Cai, W.1    Chen, X.2
  • 19
    • 0035524114 scopus 로고    scopus 로고
    • Improving the efficacy of antibody-based cancer therapies
    • Carter P. 2001. Improving the efficacy of antibody-based cancer therapies. Nature Reviews Cancer 1:118-129.
    • (2001) Nature Reviews Cancer , vol.1 , pp. 118-129
    • Carter, P.1
  • 20
    • 0029994358 scopus 로고    scopus 로고
    • Integrin-mediated activation of MEK and mitogen-activated protein kinase is independent of Ras [corrected]
    • Chen Q, Lin TH, Der CJ, Juliano RL. 1996. Integrin-mediated activation of MEK and mitogen-activated protein kinase is independent of Ras [corrected]. Journal of Biological Chemistry 271:18122-18127.
    • (1996) Journal of Biological Chemistry , vol.271 , pp. 18122-18127
    • Chen, Q.1    Lin, T.H.2    Der, C.J.3    Juliano, R.L.4
  • 21
    • 0005306564 scopus 로고
    • Human endothelial cells synthesize and express an Arg-Gly-Asp-directed adhesion receptor involved in attachment to fibrinogen and von Willebrand factor
    • Cheresh DA. 1987. Human endothelial cells synthesize and express an Arg-Gly-Asp-directed adhesion receptor involved in attachment to fibrinogen and von Willebrand factor. Proceedings of the National Academy of Sciences USA 84:6471-6475.
    • (1987) Proceedings of the National Academy of Sciences USA , vol.84 , pp. 6471-6475
    • Cheresh, D.A.1
  • 22
    • 0028037889 scopus 로고
    • Structurally distinct disintegrins contortrostatin and multisquamatin differentially regulate platelet tyrosine phosphorylation
    • Clark EA, Trikha M, Markland FS, Brugge JS. 1994. Structurally distinct disintegrins contortrostatin and multisquamatin differentially regulate platelet tyrosine phosphorylation. Journal of Biological Chemistry 269:21940-21943.
    • (1994) Journal of Biological Chemistry , vol.269 , pp. 21940-21943
    • Clark, E.A.1    Trikha, M.2    Markland, F.S.3    Brugge, J.S.4
  • 23
    • 15544361947 scopus 로고    scopus 로고
    • Colomer R. 2004. Gemcitabine and paclitaxel in metastatic breast cancer: A review. Oncology (Williston. Park) 18:8-12.
    • Colomer R. 2004. Gemcitabine and paclitaxel in metastatic breast cancer: A review. Oncology (Williston. Park) 18:8-12.
  • 24
    • 33748049409 scopus 로고    scopus 로고
    • Integrin-mediated cell-matrix interactions for prosurvival and antiapoptotic signaling after genotoxic injury
    • Cordes N. 2006. Integrin-mediated cell-matrix interactions for prosurvival and antiapoptotic signaling after genotoxic injury. Cancer Letters 242:11-19.
    • (2006) Cancer Letters , vol.242 , pp. 11-19
    • Cordes, N.1
  • 25
    • 33645104626 scopus 로고    scopus 로고
    • A small molecule, orally active, alpha4beta1/alpha4beta7 dual antagonist reduces leukocyte infiltration and airway hyper-responsiveness in an experimental model of allergic asthma in Brown Norway rats
    • Cortijo J, Sanz MJ, Iranzo A, Montesinos JL, Nabah YN, Alfon J, Gomez LA, Merlos M, Morcillo EJ. 2006. A small molecule, orally active, alpha4beta1/alpha4beta7 dual antagonist reduces leukocyte infiltration and airway hyper-responsiveness in an experimental model of allergic asthma in Brown Norway rats. British Journal of Pharmacology 147:661-670.
    • (2006) British Journal of Pharmacology , vol.147 , pp. 661-670
    • Cortijo, J.1    Sanz, M.J.2    Iranzo, A.3    Montesinos, J.L.4    Nabah, Y.N.5    Alfon, J.6    Gomez, L.A.7    Merlos, M.8    Morcillo, E.J.9
  • 27
    • 0034283814 scopus 로고    scopus 로고
    • Integrin and ECM functions: Roles in vertebrate development
    • De Arcangelis A, Georges-Labouesse E. 2000. Integrin and ECM functions: Roles in vertebrate development. Trends in Genetics 16:389-395.
    • (2000) Trends in Genetics , vol.16 , pp. 389-395
    • De Arcangelis, A.1    Georges-Labouesse, E.2
  • 32
    • 0031733974 scopus 로고    scopus 로고
    • Diversity does make a difference: Fibroblast growth factor-heparin interactions
    • Faham S, Linhardt RJ, Rees DC. 1998. Diversity does make a difference: fibroblast growth factor-heparin interactions. Current Opinion in Structural Biology 8:578-586.
    • (1998) Current Opinion in Structural Biology , vol.8 , pp. 578-586
    • Faham, S.1    Linhardt, R.J.2    Rees, D.C.3
  • 35
    • 85013312416 scopus 로고
    • Tumor angiogenesis: Therapeutic implications
    • Folkman J. 1971. Tumor angiogenesis: therapeutic implications. New England Journal of Medicine 285:1182-1186.
    • (1971) New England Journal of Medicine , vol.285 , pp. 1182-1186
    • Folkman, J.1
  • 38
    • 0022273672 scopus 로고
    • Interaction of fibronectin with its receptor on platelets
    • Gardner JM, Hynes RO. 1985. Interaction of fibronectin with its receptor on platelets. Cell 42:439-448.
    • (1985) Cell , vol.42 , pp. 439-448
    • Gardner, J.M.1    Hynes, R.O.2
  • 43
    • 33845669072 scopus 로고    scopus 로고
    • Integrin signaling in epithelial cells
    • Gilcrease MZ. 2007. Integrin signaling in epithelial cells. Cancer Letters 247:1-25.
    • (2007) Cancer Letters , vol.247 , pp. 1-25
    • Gilcrease, M.Z.1
  • 44
    • 0037186502 scopus 로고    scopus 로고
    • Nanomolar small molecule inhibitors for alphav(beta)6, alphav(beta)5, and alphav(beta)3 integrins
    • Goodman SL, Holzemann G, Sulyok GA, Kessler H. 2002. Nanomolar small molecule inhibitors for alphav(beta)6, alphav(beta)5, and alphav(beta)3 integrins. Journal of Medicinal Chemistry 45:1045-1051.
    • (2002) Journal of Medicinal Chemistry , vol.45 , pp. 1045-1051
    • Goodman, S.L.1    Holzemann, G.2    Sulyok, G.A.3    Kessler, H.4
  • 47
    • 0034040525 scopus 로고    scopus 로고
    • alpha(v)beta(3) Integrin antagonists as inhibitors of bone resorption
    • Hartman GD, Duggan ME. 2000. alpha(v)beta(3) Integrin antagonists as inhibitors of bone resorption. Expert Opinion on Investigational Drugs 9:1281-1291.
    • (2000) Expert Opinion on Investigational Drugs , vol.9 , pp. 1281-1291
    • Hartman, G.D.1    Duggan, M.E.2
  • 48
    • 0023884392 scopus 로고
    • Adherence induces selective mRNA expression of monocyte mediators and proto-oncogenes
    • Haskill S, Johnson C, Eierman D, Becker S, Warren K. 1988. Adherence induces selective mRNA expression of monocyte mediators and proto-oncogenes. Journal of Immunology 140:1690-1694.
    • (1988) Journal of Immunology , vol.140 , pp. 1690-1694
    • Haskill, S.1    Johnson, C.2    Eierman, D.3    Becker, S.4    Warren, K.5
  • 51
    • 0031814234 scopus 로고    scopus 로고
    • What have snakes taught us about integrins?
    • Huang TF. 1998. What have snakes taught us about integrins? Cellular & Molecular Life Sciences 54:527-540.
    • (1998) Cellular & Molecular Life Sciences , vol.54 , pp. 527-540
    • Huang, T.F.1
  • 52
    • 0037145037 scopus 로고    scopus 로고
    • Integrins: Bidirectional, allosteric signaling machines
    • Hynes RO. 2002. Integrins: bidirectional, allosteric signaling machines. Cell 110:673-687.
    • (2002) Cell , vol.110 , pp. 673-687
    • Hynes, R.O.1
  • 53
    • 11844254414 scopus 로고    scopus 로고
    • Normalization of tumor vasculature: An emerging concept in antiangiogenic therapy
    • Jain RK. 2005. Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy. Science 307:58-62.
    • (2005) Science , vol.307 , pp. 58-62
    • Jain, R.K.1
  • 55
    • 0033843942 scopus 로고    scopus 로고
    • Regulation of angiogenesis in vivo by ligation of integrin alpha5beta1 with the central cell-binding domain of fibronectin
    • Kim S, Bell K, Mousa SA, Varner JA. 2000. Regulation of angiogenesis in vivo by ligation of integrin alpha5beta1 with the central cell-binding domain of fibronectin. American Journal of Pathology 156:1345-1362.
    • (2000) American Journal of Pathology , vol.156 , pp. 1345-1362
    • Kim, S.1    Bell, K.2    Mousa, S.A.3    Varner, J.A.4
  • 56
    • 0027166680 scopus 로고
    • Spatial organization of microfilaments and vitronectin receptor, alpha v beta 3, in osteoclasts. A study using confocal laser scanning microscopy
    • Lakkakorpi PT, Helfrich MH, Horton MA, Vaananen HK. 1993. Spatial organization of microfilaments and vitronectin receptor, alpha v beta 3, in osteoclasts. A study using confocal laser scanning microscopy. Journal of Cell Science 104 (Pt 3):663-670.
    • (1993) Journal of Cell Science , vol.104 , Issue.PART 3 , pp. 663-670
    • Lakkakorpi, P.T.1    Helfrich, M.H.2    Horton, M.A.3    Vaananen, H.K.4
  • 65
    • 0031017220 scopus 로고    scopus 로고
    • Demonstration of mechanical connections between integrins, cytoskeletal filaments, and nucleoplasm that stabilize nuclear structure
    • Maniotis AJ, Chen CS, Ingber DE. 1997. Demonstration of mechanical connections between integrins, cytoskeletal filaments, and nucleoplasm that stabilize nuclear structure. Proceedings of the National Academy of Sciences USA 94:849-854.
    • (1997) Proceedings of the National Academy of Sciences USA , vol.94 , pp. 849-854
    • Maniotis, A.J.1    Chen, C.S.2    Ingber, D.E.3
  • 67
    • 0023649186 scopus 로고
    • Occupation of the extracellular matrix receptor, integrin, is a control point for myogenic differentiation
    • Menko AS, Boettiger D. 1987. Occupation of the extracellular matrix receptor, integrin, is a control point for myogenic differentiation. Cell 51:51-57.
    • (1987) Cell , vol.51 , pp. 51-57
    • Menko, A.S.1    Boettiger, D.2
  • 72
    • 0021271957 scopus 로고
    • Cell attachment activity of fibronectin can be duplicated by small synthetic fragments of the molecule
    • Pierschbacher MD, Ruoslahti E. 1984. Cell attachment activity of fibronectin can be duplicated by small synthetic fragments of the molecule. Nature 309:30-33.
    • (1984) Nature , vol.309 , pp. 30-33
    • Pierschbacher, M.D.1    Ruoslahti, E.2
  • 76
    • 0036884547 scopus 로고    scopus 로고
    • Integrin alpha(v)beta3 targeted therapy for Kaposi's sarcoma with an in vitro evolved antibody
    • Rader C, Popkov M, Neves JA, Barbas CF III. 2002. Integrin alpha(v)beta3 targeted therapy for Kaposi's sarcoma with an in vitro evolved antibody. FASEB Journal 16:2000-2002.
    • (2002) FASEB Journal , vol.16 , pp. 2000-2002
    • Rader, C.1    Popkov, M.2    Neves, J.A.3    Barbas III, C.F.4
  • 77
    • 0346158521 scopus 로고    scopus 로고
    • Cilengitide (EMD 121974) arrests the growth of a heavily pretreated highly vascularised head and neck tumour
    • Raguse JD, Gath HJ, Bier J, Riess H, Oettle H. 2004. Cilengitide (EMD 121974) arrests the growth of a heavily pretreated highly vascularised head and neck tumour. Oral Oncology 40:228-230.
    • (2004) Oral Oncology , vol.40 , pp. 228-230
    • Raguse, J.D.1    Gath, H.J.2    Bier, J.3    Riess, H.4    Oettle, H.5
  • 79
    • 0030766846 scopus 로고    scopus 로고
    • Growth factor activation of MAP kinase requires cell adhesion
    • Renshaw MW, Ren XD, Schwartz MA. 1997. Growth factor activation of MAP kinase requires cell adhesion. EMBO Journal 16:5592-5599.
    • (1997) EMBO Journal , vol.16 , pp. 5592-5599
    • Renshaw, M.W.1    Ren, X.D.2    Schwartz, M.A.3
  • 80
    • 0032529848 scopus 로고    scopus 로고
    • Loss of beta1 integrin function results in a retardation of myogenic, but an acceleration of neuronal, differentiation of embryonic stem cells in vitro
    • Rohwedel J, Guan K, Zuschratter W, Jin S, Hnert-Hilger G, Furst D, Fassler R, Wobus AM. 1998. Loss of beta1 integrin function results in a retardation of myogenic, but an acceleration of neuronal, differentiation of embryonic stem cells in vitro. Developmental Biology 201:167-184.
    • (1998) Developmental Biology , vol.201 , pp. 167-184
    • Rohwedel, J.1    Guan, K.2    Zuschratter, W.3    Jin, S.4    Hnert-Hilger, G.5    Furst, D.6    Fassler, R.7    Wobus, A.M.8
  • 82
    • 0031915021 scopus 로고    scopus 로고
    • Integrin signalling and tyrosine phosphorylation: Just the FAKs?
    • Schlaepfer DD, Hunter T. 1998. Integrin signalling and tyrosine phosphorylation: Just the FAKs? Trends in Cell Biology 8:151-157.
    • (1998) Trends in Cell Biology , vol.8 , pp. 151-157
    • Schlaepfer, D.D.1    Hunter, T.2
  • 83
    • 23744451167 scopus 로고    scopus 로고
    • Integrins and Src: Dynamic duo of adhesion signaling
    • Shattil SJ. 2005. Integrins and Src: Dynamic duo of adhesion signaling. Trends in Cell Biology 15:399-403.
    • (2005) Trends in Cell Biology , vol.15 , pp. 399-403
    • Shattil, S.J.1
  • 84
    • 33744967049 scopus 로고    scopus 로고
    • Integrin signals, transcription factors, and monocyte differentiation
    • Shi C, Simon DI. 2006. Integrin signals, transcription factors, and monocyte differentiation. Trends in Cardiovascular Medicine 16:146-152.
    • (2006) Trends in Cardiovascular Medicine , vol.16 , pp. 146-152
    • Shi, C.1    Simon, D.I.2
  • 85
    • 0142026204 scopus 로고    scopus 로고
    • Therapeutic antagonists and conformational regulation of integrin function
    • Shimaoka M, Springer TA. 2003. Therapeutic antagonists and conformational regulation of integrin function. Nature Reviews Drug Discovery 2:703-716.
    • (2003) Nature Reviews Drug Discovery , vol.2 , pp. 703-716
    • Shimaoka, M.1    Springer, T.A.2
  • 91
    • 0030018743 scopus 로고    scopus 로고
    • A systems approach to cancer therapy. (Antioncogenics+standard cytotoxics ->mechanism(s) of interaction)
    • Teicher BA. 1996. A systems approach to cancer therapy. (Antioncogenics+standard cytotoxics ->mechanism(s) of interaction). Cancer and Metastasis Reviews 15:247-272.
    • (1996) Cancer and Metastasis Reviews , vol.15 , pp. 247-272
    • Teicher, B.A.1
  • 93
    • 0037092984 scopus 로고    scopus 로고
    • Multiple roles for platelet GPIIb/IIIa and alphavbeta3 integrins in tumor growth, angiogenesis, and metastasis
    • Trikha M, Zhou Z, Timar J, Raso E, Kennel M, Emmell E, Nakada MT. 2002. Multiple roles for platelet GPIIb/IIIa and alphavbeta3 integrins in tumor growth, angiogenesis, and metastasis. Cancer Research 62:2824-2833.
    • (2002) Cancer Research , vol.62 , pp. 2824-2833
    • Trikha, M.1    Zhou, Z.2    Timar, J.3    Raso, E.4    Kennel, M.5    Emmell, E.6    Nakada, M.T.7
  • 96
    • 0028979701 scopus 로고
    • Integrin alpha 5 beta 1 expression negatively regulates cell growth: Reversal by attachment to fibronectin
    • Varner JA, Emerson DA, Juliano RL. 1995. Integrin alpha 5 beta 1 expression negatively regulates cell growth: Reversal by attachment to fibronectin. Molecular Biology of the Cell 6:725-740.
    • (1995) Molecular Biology of the Cell , vol.6 , pp. 725-740
    • Varner, J.A.1    Emerson, D.A.2    Juliano, R.L.3
  • 97
    • 0036683057 scopus 로고    scopus 로고
    • Role of integrins in regulating epidermal adhesion, growth and differentiation
    • Watt FM. 2002. Role of integrins in regulating epidermal adhesion, growth and differentiation. EMBO Journal 21:3919-3926.
    • (2002) EMBO Journal , vol.21 , pp. 3919-3926
    • Watt, F.M.1
  • 98
    • 0036726312 scopus 로고    scopus 로고
    • beta4 integrin-dependent formation of polarized three-dimensional architecture confers resistance to apoptosis in normal and malignant mammary epithelium
    • Weaver VM, Lelievre S, Lakins JN, Chrenek MA, Jones JC, Giancotti F, Werb Z, Bissell MJ. 2002. beta4 integrin-dependent formation of polarized three-dimensional architecture confers resistance to apoptosis in normal and malignant mammary epithelium. Cancer Cell 2:205-216.
    • (2002) Cancer Cell , vol.2 , pp. 205-216
    • Weaver, V.M.1    Lelievre, S.2    Lakins, J.N.3    Chrenek, M.A.4    Jones, J.C.5    Giancotti, F.6    Werb, Z.7    Bissell, M.J.8
  • 99
    • 27144550160 scopus 로고    scopus 로고
    • Arming antibodies: Prospects and challenges for immunoconjugates
    • Wu AM, Senter PD. 2005. Arming antibodies: Prospects and challenges for immunoconjugates. Nature Biotechnology 23:1137-1146.
    • (2005) Nature Biotechnology , vol.23 , pp. 1137-1146
    • Wu, A.M.1    Senter, P.D.2
  • 100
    • 0036229695 scopus 로고    scopus 로고
    • Integrin regulation of growth factor receptors
    • Yamada KM, Even-Ram S. 2002. Integrin regulation of growth factor receptors. Nature Cell Biology 4:E75-76.
    • (2002) Nature Cell Biology , vol.4
    • Yamada, K.M.1    Even-Ram, S.2


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