VEGF Trap complex formation measures production rates of VEGF, providing a biomarker for predicting efficacious angiogenic blockade

Proceedings of the National Academy of Sciences of the United States of America

Volumn 104, Issue 47, 2007, Pages 18363-18370

  Rudge, John S ^a   Holash, Jocelyn ^a,b   Hylton, Donna ^a   Russell, Michelle ^a   Jiang, Shelly ^a   Leidich, Raymond ^a   Papadopoulos, Nicholas ^a   Pyles, Erica A ^a   Torri, Al ^a   Wiegand, Stanley J ^a   Thurston, Gavin ^a   Stahl, Neil ^a   Yancopoulos, George D ^a  

^a REGENERON PHARMACEUTICALS INC   (United States)

^b NOVARTIS   (United States)

Author keywords

Aflibercept; Angiogenesis; Endothelial cell; Tumor

Indexed keywords

ANGIOGENESIS INHIBITOR; ANTIBODY; BEVACIZUMAB; BIOLOGICAL MARKER; PLACENTAL GROWTH FACTOR; VASCULOTROPIN; VASCULOTROPIN ANTIBODY; VASCULOTROPIN INHIBITOR;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN ANTIBODY COMPLEX; ARTICLE; CLINICAL RESEARCH; COMPLEX FORMATION; CONTROLLED STUDY; DOSE RESPONSE; ENDOTHELIUM CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; TUMOR; TUMOR VOLUME; AGING; ANIMAL; BIOSYNTHESIS; BLOOD; DRUG SCREENING; HUMAN; IMMUNOLOGY; MALE; METABOLISM; MOUSE MUTANT; PATHOLOGY; PHYSIOLOGY; TUMOR CELL LINE; UTERINE CERVIX CARCINOMA IN SITU;

RODENTIA;

AGING; ANGIOGENESIS INHIBITORS; ANIMALS; ANTIBODIES; BIOLOGICAL MARKERS; CELL LINE, TUMOR; CERVICAL INTRAEPITHELIAL NEOPLASIA; HUMANS; MALE; MICE; MICE, SCID; PROTEIN BINDING; VASCULAR ENDOTHELIAL GROWTH FACTORS; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 36749040908     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0708865104     Document Type: Article

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