메뉴 건너뛰기




Volumn 37, Issue 6, 2011, Pages 444-455

Oral/metronomic cyclophosphamide-based chemotherapy as option for patients with castration-refractory prostate cancer - Review of the literature

Author keywords

Androgen independent prostate cancer; Castration refractory prostate cancer; Hormone refractory prostate cancer; Metronomic chemotherapy Cyclophosphamide; Oral chemotherapy; Prostate cancer

Indexed keywords

CELECOXIB; COTRIMOXAZOLE; CYCLOPHOSPHAMIDE; DEXAMETHASONE; DIETHYLSTILBESTROL; DOCETAXEL; ESTRAMUSTINE; ETOPOSIDE; FLUOROURACIL; METHOTREXATE; PREDNISONE; THALIDOMIDE; UFT;

EID: 79960999855     PISSN: 03057372     EISSN: 15321967     Source Type: Journal    
DOI: 10.1016/j.ctrv.2010.12.006     Document Type: Review
Times cited : (38)

References (71)
  • 2
    • 0024324367 scopus 로고
    • A controlled trial of leuprolide with and without flutamide in prostatic carcinoma
    • Crawford E.D., Eisenberger M.A., McLeod D.G., et al. A controlled trial of leuprolide with and without flutamide in prostatic carcinoma. N Engl J Med 1989, 321:419-424.
    • (1989) N Engl J Med , vol.321 , pp. 419-424
    • Crawford, E.D.1    Eisenberger, M.A.2    McLeod, D.G.3
  • 3
    • 0032497522 scopus 로고    scopus 로고
    • Bilateral orchiectomy with or without flutamide for metastatic prostate cancer
    • Eisenberger M.A., Blumenstein B.A., Crawford E.D., et al. Bilateral orchiectomy with or without flutamide for metastatic prostate cancer. N Engl J Med 1998, 339:1036-1042.
    • (1998) N Engl J Med , vol.339 , pp. 1036-1042
    • Eisenberger, M.A.1    Blumenstein, B.A.2    Crawford, E.D.3
  • 5
    • 0032784113 scopus 로고    scopus 로고
    • Hydrocortisone with or without mitoxantrone in men with hormone-refractory prostate cancer: results of the cancer and leukemia group B 9182 study
    • Kantoff P.W., Halabi S., Conaway M., et al. Hydrocortisone with or without mitoxantrone in men with hormone-refractory prostate cancer: results of the cancer and leukemia group B 9182 study. J Clin Oncol 1999, 17:2506-2513.
    • (1999) J Clin Oncol , vol.17 , pp. 2506-2513
    • Kantoff, P.W.1    Halabi, S.2    Conaway, M.3
  • 6
    • 8944220720 scopus 로고    scopus 로고
    • Chemotherapy with mitoxantrone plus prednisone or prednisone alone for symptomatic hormone-resistant prostate cancer: a Canadian randomized trial with palliative end points
    • Tannock I.F., Osoba D., Stockler M.R., et al. Chemotherapy with mitoxantrone plus prednisone or prednisone alone for symptomatic hormone-resistant prostate cancer: a Canadian randomized trial with palliative end points. J Clin Oncol 1996, 14:1756-1764.
    • (1996) J Clin Oncol , vol.14 , pp. 1756-1764
    • Tannock, I.F.1    Osoba, D.2    Stockler, M.R.3
  • 7
    • 35448959580 scopus 로고    scopus 로고
    • Addition of estramustine to chemotherapy and survival of patients with castration-refractory prostate cancer: a meta-analysis of individual patient data
    • Fizazi K., Le Maitre A., Hudes G., et al. Addition of estramustine to chemotherapy and survival of patients with castration-refractory prostate cancer: a meta-analysis of individual patient data. Lancet Oncol 2007, 8:994-1000.
    • (2007) Lancet Oncol , vol.8 , pp. 994-1000
    • Fizazi, K.1    Le Maitre, A.2    Hudes, G.3
  • 8
    • 4744337716 scopus 로고    scopus 로고
    • Docetaxel and estramustine compared with mitoxantrone and prednisone for advanced refractory prostate cancer
    • Petrylak D.P., Tangen C.M., Hussain M.H., et al. Docetaxel and estramustine compared with mitoxantrone and prednisone for advanced refractory prostate cancer. N Engl J Med 2004, 351:1513-1520.
    • (2004) N Engl J Med , vol.351 , pp. 1513-1520
    • Petrylak, D.P.1    Tangen, C.M.2    Hussain, M.H.3
  • 9
    • 4744366279 scopus 로고    scopus 로고
    • Docetaxel plus prednisone or mitoxantrone plus prednisone for advanced prostate cancer
    • Tannock I.F., de Wit R., Berry W.R., et al. Docetaxel plus prednisone or mitoxantrone plus prednisone for advanced prostate cancer. N Engl J Med 2004, 351:1502-1512.
    • (2004) N Engl J Med , vol.351 , pp. 1502-1512
    • Tannock, I.F.1    de Wit, R.2    Berry, W.R.3
  • 10
    • 71249094779 scopus 로고    scopus 로고
    • Sagopilone, a microtubule stabilizer for the potential treatment of cancer
    • Galmarini C.M. Sagopilone, a microtubule stabilizer for the potential treatment of cancer. Curr Opin Investig Drugs 2009, 10:1359-1371.
    • (2009) Curr Opin Investig Drugs , vol.10 , pp. 1359-1371
    • Galmarini, C.M.1
  • 11
    • 61649126264 scopus 로고    scopus 로고
    • Phase II trial of weekly patupilone in patients with castration-resistant prostate cancer
    • Hussain A., DiPaola R.S., Baron A.D., et al. Phase II trial of weekly patupilone in patients with castration-resistant prostate cancer. Ann Oncol 2009, 20:492-497.
    • (2009) Ann Oncol , vol.20 , pp. 492-497
    • Hussain, A.1    DiPaola, R.S.2    Baron, A.D.3
  • 12
    • 79961005665 scopus 로고    scopus 로고
    • Epothilones in prostate cancer
    • Kelly W.K. Epothilones in prostate cancer. Urol Oncol 2009.
    • (2009) Urol Oncol
    • Kelly, W.K.1
  • 13
    • 67649974684 scopus 로고    scopus 로고
    • Phase I study of ixabepilone, mitoxantrone, and prednisone in patients with metastatic castration resistant prostate cancer previously treated with docetaxel-based therapy: a study of the department of defense prostate cancer clinical trials consortium
    • Rosenberg J.E., Ryan C.J., Weinberg V.K., et al. Phase I study of ixabepilone, mitoxantrone, and prednisone in patients with metastatic castration resistant prostate cancer previously treated with docetaxel-based therapy: a study of the department of defense prostate cancer clinical trials consortium. J Clin Oncol 2009.
    • (2009) J Clin Oncol
    • Rosenberg, J.E.1    Ryan, C.J.2    Weinberg, V.K.3
  • 14
    • 34547119271 scopus 로고    scopus 로고
    • Activity of second-line chemotherapy in docetaxel-refractory hormone-refractory prostate cancer patients: randomized phase 2 study of ixabepilone or mitoxantrone and prednisone
    • Rosenberg J.E., Weinberg V.K., Kelly W.K., et al. Activity of second-line chemotherapy in docetaxel-refractory hormone-refractory prostate cancer patients: randomized phase 2 study of ixabepilone or mitoxantrone and prednisone. Cancer 2007, 110:556-563.
    • (2007) Cancer , vol.110 , pp. 556-563
    • Rosenberg, J.E.1    Weinberg, V.K.2    Kelly, W.K.3
  • 15
    • 68949094223 scopus 로고    scopus 로고
    • Selective inhibition of CYP17 with abiraterone acetate is highly active in the treatment of castration-resistant prostate cancer
    • Attard G., Reid A.H., A'Hern R., et al. Selective inhibition of CYP17 with abiraterone acetate is highly active in the treatment of castration-resistant prostate cancer. J Clin Oncol 2009, 27:3742-3748.
    • (2009) J Clin Oncol , vol.27 , pp. 3742-3748
    • Attard, G.1    Reid, A.H.2    A'Hern, R.3
  • 16
    • 53749090666 scopus 로고    scopus 로고
    • Phase I clinical trial of a selective inhibitor of CYP17, abiraterone acetate, confirms that castration-resistant prostate cancer commonly remains hormone driven
    • Attard G., Reid A.H., Yap T.A., et al. Phase I clinical trial of a selective inhibitor of CYP17, abiraterone acetate, confirms that castration-resistant prostate cancer commonly remains hormone driven. J Clin Oncol 2008, 26:4563-4571.
    • (2008) J Clin Oncol , vol.26 , pp. 4563-4571
    • Attard, G.1    Reid, A.H.2    Yap, T.A.3
  • 17
    • 77951591066 scopus 로고    scopus 로고
    • Phase II multicenter study of abiraterone acetate plus prednisone therapy in patients with docetaxel-treated castration-resistant prostate cancer
    • Danila D.C., Morris M.J., de Bono J.S., et al. Phase II multicenter study of abiraterone acetate plus prednisone therapy in patients with docetaxel-treated castration-resistant prostate cancer. J Clin Oncol 2010, 28:1496-1501.
    • (2010) J Clin Oncol , vol.28 , pp. 1496-1501
    • Danila, D.C.1    Morris, M.J.2    de Bono, J.S.3
  • 18
    • 77951518711 scopus 로고    scopus 로고
    • Significant and sustained antitumor activity in post-docetaxel, castration-resistant prostate cancer with the CYP17 inhibitor abiraterone acetate
    • Reid A.H., Attard G., Danila D.C., et al. Significant and sustained antitumor activity in post-docetaxel, castration-resistant prostate cancer with the CYP17 inhibitor abiraterone acetate. J Clin Oncol 2010, 28:1489-1495.
    • (2010) J Clin Oncol , vol.28 , pp. 1489-1495
    • Reid, A.H.1    Attard, G.2    Danila, D.C.3
  • 19
    • 51449124047 scopus 로고    scopus 로고
    • Targeting CYP17: established and novel approaches in prostate cancer
    • Yap T.A., Carden C.P., Attard G., de Bono J.S. Targeting CYP17: established and novel approaches in prostate cancer. Curr Opin Pharmacol 2008, 8:449-457.
    • (2008) Curr Opin Pharmacol , vol.8 , pp. 449-457
    • Yap, T.A.1    Carden, C.P.2    Attard, G.3    de Bono, J.S.4
  • 20
    • 65649090203 scopus 로고    scopus 로고
    • Development of a second-generation antiandrogen for treatment of advanced prostate cancer
    • Tran C., Ouk S., Clegg N.J., et al. Development of a second-generation antiandrogen for treatment of advanced prostate cancer. Science 2009, 324:787-790.
    • (2009) Science , vol.324 , pp. 787-790
    • Tran, C.1    Ouk, S.2    Clegg, N.J.3
  • 21
    • 75949107937 scopus 로고    scopus 로고
    • VEGF inhibitors and prostate cancer therapy
    • Aragon-Ching J.B., Dahut W.L. VEGF inhibitors and prostate cancer therapy. Curr Mol Pharmacol 2009, 2:161-168.
    • (2009) Curr Mol Pharmacol , vol.2 , pp. 161-168
    • Aragon-Ching, J.B.1    Dahut, W.L.2
  • 22
    • 0034795178 scopus 로고    scopus 로고
    • A randomized phase II trial of docetaxel (taxotere) plus thalidomide in androgen-independent prostate cancer
    • Figg W.D., Arlen P., Gulley J., et al. A randomized phase II trial of docetaxel (taxotere) plus thalidomide in androgen-independent prostate cancer. Semin Oncol 2001, 28:62-66.
    • (2001) Semin Oncol , vol.28 , pp. 62-66
    • Figg, W.D.1    Arlen, P.2    Gulley, J.3
  • 23
    • 77951887506 scopus 로고    scopus 로고
    • Sunitinib malate for metastatic castration-resistant prostate cancer following docetaxel-based chemotherapy
    • Sonpavde G., Periman P.O., Bernold D., et al. Sunitinib malate for metastatic castration-resistant prostate cancer following docetaxel-based chemotherapy. Ann Oncol 2010, 21:319-324.
    • (2010) Ann Oncol , vol.21 , pp. 319-324
    • Sonpavde, G.1    Periman, P.O.2    Bernold, D.3
  • 24
    • 58149391399 scopus 로고    scopus 로고
    • Custirsen (OGX-011): a second-generation antisense inhibitor of clusterin for the treatment of cancer
    • Chi K.N., Zoubeidi A., Gleave M.E. Custirsen (OGX-011): a second-generation antisense inhibitor of clusterin for the treatment of cancer. Expert Opin Investig Drugs 2008, 17:1955-1962.
    • (2008) Expert Opin Investig Drugs , vol.17 , pp. 1955-1962
    • Chi, K.N.1    Zoubeidi, A.2    Gleave, M.E.3
  • 25
    • 70549105748 scopus 로고    scopus 로고
    • Phase II, two-stage, single-arm trial of the histone deacetylase inhibitor (HDACi) romidepsin in metastatic castration-resistant prostate cancer (CRPC)
    • Molife L.R., Attard G., Fong P.C., et al. Phase II, two-stage, single-arm trial of the histone deacetylase inhibitor (HDACi) romidepsin in metastatic castration-resistant prostate cancer (CRPC). Ann Oncol 2010, 21:109-113.
    • (2010) Ann Oncol , vol.21 , pp. 109-113
    • Molife, L.R.1    Attard, G.2    Fong, P.C.3
  • 26
    • 55549112219 scopus 로고    scopus 로고
    • Phase 3, randomized, controlled trial of atrasentan in patients with nonmetastatic, hormone-refractory prostate cancer
    • Nelson J.B., Love W., Chin J.L., et al. Phase 3, randomized, controlled trial of atrasentan in patients with nonmetastatic, hormone-refractory prostate cancer. Cancer 2008, 113:2478-2487.
    • (2008) Cancer , vol.113 , pp. 2478-2487
    • Nelson, J.B.1    Love, W.2    Chin, J.L.3
  • 27
    • 66149164441 scopus 로고    scopus 로고
    • SRC family kinase activity is up-regulated in hormone-refractory prostate cancer
    • Tatarov O., Mitchell T.J., Seywright M., et al. SRC family kinase activity is up-regulated in hormone-refractory prostate cancer. Clin Cancer Res 2009, 15:3540-3549.
    • (2009) Clin Cancer Res , vol.15 , pp. 3540-3549
    • Tatarov, O.1    Mitchell, T.J.2    Seywright, M.3
  • 28
    • 52049090425 scopus 로고    scopus 로고
    • Phase 1/2 dose-escalation study of a GM-CSF-secreting, allogeneic, cellular immunotherapy for metastatic hormone-refractory prostate cancer
    • Higano C.S., Corman J.M., Smith D.C., et al. Phase 1/2 dose-escalation study of a GM-CSF-secreting, allogeneic, cellular immunotherapy for metastatic hormone-refractory prostate cancer. Cancer 2008, 113:975-984.
    • (2008) Cancer , vol.113 , pp. 975-984
    • Higano, C.S.1    Corman, J.M.2    Smith, D.C.3
  • 29
    • 68549135290 scopus 로고    scopus 로고
    • Integrated data from 2 randomized, double-blind, placebo-controlled, phase 3 trials of active cellular immunotherapy with sipuleucel-T in advanced prostate cancer
    • Higano C.S., Schellhammer P.F., Small E.J., et al. Integrated data from 2 randomized, double-blind, placebo-controlled, phase 3 trials of active cellular immunotherapy with sipuleucel-T in advanced prostate cancer. Cancer 2009, 115:3670-3679.
    • (2009) Cancer , vol.115 , pp. 3670-3679
    • Higano, C.S.1    Schellhammer, P.F.2    Small, E.J.3
  • 30
    • 70449090422 scopus 로고    scopus 로고
    • Anti-epidermal growth factor receptor monoclonal antibody cetuximab plus Doxorubicin in the treatment of metastatic castration-resistant prostate cancer
    • Slovin S.F., Kelly W.K., Wilton A., et al. Anti-epidermal growth factor receptor monoclonal antibody cetuximab plus Doxorubicin in the treatment of metastatic castration-resistant prostate cancer. Clin Genitourin Cancer 2009, 7:E77-E82.
    • (2009) Clin Genitourin Cancer , vol.7
    • Slovin, S.F.1    Kelly, W.K.2    Wilton, A.3
  • 31
    • 3943104783 scopus 로고    scopus 로고
    • The use of trastuzumab in the treatment of hormone refractory prostate cancer; phase II trial
    • Ziada A., Barqawi A., Glode L.M., et al. The use of trastuzumab in the treatment of hormone refractory prostate cancer; phase II trial. Prostate 2004, 60:332-337.
    • (2004) Prostate , vol.60 , pp. 332-337
    • Ziada, A.1    Barqawi, A.2    Glode, L.M.3
  • 32
    • 15944410592 scopus 로고    scopus 로고
    • Inhibition of CD4(+)25+ T regulatory cell function implicated in enhanced immune response by low-dose cyclophosphamide
    • Lutsiak M.E., Semnani R.T., De Pascalis R., et al. Inhibition of CD4(+)25+ T regulatory cell function implicated in enhanced immune response by low-dose cyclophosphamide. Blood 2005, 105:2862-2868.
    • (2005) Blood , vol.105 , pp. 2862-2868
    • Lutsiak, M.E.1    Semnani, R.T.2    De Pascalis, R.3
  • 33
    • 33744503923 scopus 로고    scopus 로고
    • The anti-tumour effect of low-dose continuous chemotherapy may partly be mediated by thrombospondin
    • Damber J.E., Vallbo C., Albertsson P., Lennernas B., Norrby K. The anti-tumour effect of low-dose continuous chemotherapy may partly be mediated by thrombospondin. Cancer Chemother Pharmacol 2006, 58:354-360.
    • (2006) Cancer Chemother Pharmacol , vol.58 , pp. 354-360
    • Damber, J.E.1    Vallbo, C.2    Albertsson, P.3    Lennernas, B.4    Norrby, K.5
  • 34
    • 68049137904 scopus 로고    scopus 로고
    • Clinical and pharmacodynamic evaluation of metronomic cyclophosphamide, celecoxib, and dexamethasone in advanced hormone-refractory prostate cancer
    • Fontana A., Galli L., Fioravanti A., et al. Clinical and pharmacodynamic evaluation of metronomic cyclophosphamide, celecoxib, and dexamethasone in advanced hormone-refractory prostate cancer. Clin Cancer Res 2009, 15:4954-4962.
    • (2009) Clin Cancer Res , vol.15 , pp. 4954-4962
    • Fontana, A.1    Galli, L.2    Fioravanti, A.3
  • 35
    • 0027504768 scopus 로고
    • Oral cyclophosphamide for the management of hormone-refractory prostate cancer
    • Raghavan D., Cox K., Pearson B.S., et al. Oral cyclophosphamide for the management of hormone-refractory prostate cancer. Br J Urol 1993, 72:625-628.
    • (1993) Br J Urol , vol.72 , pp. 625-628
    • Raghavan, D.1    Cox, K.2    Pearson, B.S.3
  • 36
    • 0034048358 scopus 로고    scopus 로고
    • Less is more, regularly: metronomic dosing of cytotoxic drugs can target tumor angiogenesis in mice
    • Hanahan D., Bergers G., Bergsland E. Less is more, regularly: metronomic dosing of cytotoxic drugs can target tumor angiogenesis in mice. J Clin Invest 2000, 105:1045-1047.
    • (2000) J Clin Invest , vol.105 , pp. 1045-1047
    • Hanahan, D.1    Bergers, G.2    Bergsland, E.3
  • 37
    • 0034032882 scopus 로고    scopus 로고
    • Antiangiogenic scheduling of chemotherapy improves efficacy against experimental drug-resistant cancer
    • Browder T., Butterfield C.E., Kraling B.M., et al. Antiangiogenic scheduling of chemotherapy improves efficacy against experimental drug-resistant cancer. Cancer Res 2000, 60:1878-1886.
    • (2000) Cancer Res , vol.60 , pp. 1878-1886
    • Browder, T.1    Butterfield, C.E.2    Kraling, B.M.3
  • 38
    • 0037093209 scopus 로고    scopus 로고
    • Antitumor effects in mice of low-dose (metronomic) cyclophosphamide administered continuously through the drinking water
    • Man S., Bocci G., Francia G., et al. Antitumor effects in mice of low-dose (metronomic) cyclophosphamide administered continuously through the drinking water. Cancer Res 2002, 62:2731-2735.
    • (2002) Cancer Res , vol.62 , pp. 2731-2735
    • Man, S.1    Bocci, G.2    Francia, G.3
  • 39
    • 23844538059 scopus 로고    scopus 로고
    • Low-dose metronomic combined with intermittent bolus-dose cyclophosphamide is an effective long-term chemotherapy treatment strategy
    • Shaked Y., Emmenegger U., Francia G., et al. Low-dose metronomic combined with intermittent bolus-dose cyclophosphamide is an effective long-term chemotherapy treatment strategy. Cancer Res 2005, 65:7045-7051.
    • (2005) Cancer Res , vol.65 , pp. 7045-7051
    • Shaked, Y.1    Emmenegger, U.2    Francia, G.3
  • 40
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • Hanahan D., Weinberg R.A. The hallmarks of cancer. Cell 2000, 100:57-70.
    • (2000) Cell , vol.100 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 41
    • 0030576517 scopus 로고    scopus 로고
    • Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis
    • Hanahan D., Folkman J. Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. Cell 1996, 86:353-364.
    • (1996) Cell , vol.86 , pp. 353-364
    • Hanahan, D.1    Folkman, J.2
  • 42
    • 0032952010 scopus 로고    scopus 로고
    • Selective ablation of immature blood vessels in established human tumors follows vascular endothelial growth factor withdrawal
    • Benjamin L.E., Golijanin D., Itin A., Pode D., Keshet E. Selective ablation of immature blood vessels in established human tumors follows vascular endothelial growth factor withdrawal. J Clin Invest 1999, 103:159-165.
    • (1999) J Clin Invest , vol.103 , pp. 159-165
    • Benjamin, L.E.1    Golijanin, D.2    Itin, A.3    Pode, D.4    Keshet, E.5
  • 43
    • 0034087691 scopus 로고    scopus 로고
    • Continuous low-dose therapy with vinblastine and VEGF receptor-2 antibody induces sustained tumor regression without overt toxicity
    • Klement G., Baruchel S., Rak J., et al. Continuous low-dose therapy with vinblastine and VEGF receptor-2 antibody induces sustained tumor regression without overt toxicity. J Clin Invest 2000, 105:R15-R24.
    • (2000) J Clin Invest , vol.105
    • Klement, G.1    Baruchel, S.2    Rak, J.3
  • 44
    • 0032762952 scopus 로고    scopus 로고
    • Antiangiogenesis is produced by nontoxic doses of vinblastine
    • Vacca A., Iurlaro M., Ribatti D., et al. Antiangiogenesis is produced by nontoxic doses of vinblastine. Blood 1999, 94:4143-4155.
    • (1999) Blood , vol.94 , pp. 4143-4155
    • Vacca, A.1    Iurlaro, M.2    Ribatti, D.3
  • 45
    • 0031870832 scopus 로고    scopus 로고
    • Monoclonal antibodies targeting the VEGF receptor-2 (Flk1/KDR) as an anti-angiogenic therapeutic strategy
    • Witte L., Hicklin D.J., Zhu Z., et al. Monoclonal antibodies targeting the VEGF receptor-2 (Flk1/KDR) as an anti-angiogenic therapeutic strategy. Cancer Metastasis Rev 1998, 17:155-161.
    • (1998) Cancer Metastasis Rev , vol.17 , pp. 155-161
    • Witte, L.1    Hicklin, D.J.2    Zhu, Z.3
  • 46
    • 0036897097 scopus 로고    scopus 로고
    • Protracted low-dose effects on human endothelial cell proliferation and survival in vitro reveal a selective antiangiogenic window for various chemotherapeutic drugs
    • Bocci G., Nicolaou K.C., Kerbel R.S. Protracted low-dose effects on human endothelial cell proliferation and survival in vitro reveal a selective antiangiogenic window for various chemotherapeutic drugs. Cancer Res 2002, 62:6938-6943.
    • (2002) Cancer Res , vol.62 , pp. 6938-6943
    • Bocci, G.1    Nicolaou, K.C.2    Kerbel, R.S.3
  • 47
    • 25144488561 scopus 로고    scopus 로고
    • Metronomic low-dose chemotherapy boosts CD95-dependent antiangiogenic effect of the thrombospondin peptide ABT-510: a complementation antiangiogenic strategy
    • Yap R., Veliceasa D., Emmenegger U., et al. Metronomic low-dose chemotherapy boosts CD95-dependent antiangiogenic effect of the thrombospondin peptide ABT-510: a complementation antiangiogenic strategy. Clin Cancer Res 2005, 11:6678-6685.
    • (2005) Clin Cancer Res , vol.11 , pp. 6678-6685
    • Yap, R.1    Veliceasa, D.2    Emmenegger, U.3
  • 48
    • 0242331613 scopus 로고    scopus 로고
    • Thrombospondin 1, a mediator of the antiangiogenic effects of low-dose metronomic chemotherapy
    • Bocci G., Francia G., Man S., Lawler J., Kerbel R.S. Thrombospondin 1, a mediator of the antiangiogenic effects of low-dose metronomic chemotherapy. Proc Natl Acad Sci USA 2003, 100:12917-12922.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 12917-12922
    • Bocci, G.1    Francia, G.2    Man, S.3    Lawler, J.4    Kerbel, R.S.5
  • 49
    • 0041589524 scopus 로고    scopus 로고
    • Maximum tolerable dose and low-dose metronomic chemotherapy have opposite effects on the mobilization and viability of circulating endothelial progenitor cells
    • Bertolini F., Paul S., Mancuso P., et al. Maximum tolerable dose and low-dose metronomic chemotherapy have opposite effects on the mobilization and viability of circulating endothelial progenitor cells. Cancer Res 2003, 63:4342-4346.
    • (2003) Cancer Res , vol.63 , pp. 4342-4346
    • Bertolini, F.1    Paul, S.2    Mancuso, P.3
  • 50
    • 0347626100 scopus 로고    scopus 로고
    • Synergistic effect of metronomic dosing of cyclophosphamide combined with specific antitumor immunotherapy in a murine melanoma model
    • Hermans I.F., Chong T.W., Palmowski M.J., Harris A.L., Cerundolo V. Synergistic effect of metronomic dosing of cyclophosphamide combined with specific antitumor immunotherapy in a murine melanoma model. Cancer Res 2003, 63:8408-8413.
    • (2003) Cancer Res , vol.63 , pp. 8408-8413
    • Hermans, I.F.1    Chong, T.W.2    Palmowski, M.J.3    Harris, A.L.4    Cerundolo, V.5
  • 51
    • 34548284038 scopus 로고    scopus 로고
    • Thalidomide in combination with oral daily cyclophosphamide in patients with pretreated hormone refractory prostate cancer: a phase I clinical trial
    • Di Lorenzo G., Autorino R., De Laurentiis M., et al. Thalidomide in combination with oral daily cyclophosphamide in patients with pretreated hormone refractory prostate cancer: a phase I clinical trial. Cancer Biol Ther 2007, 6:313-317.
    • (2007) Cancer Biol Ther , vol.6 , pp. 313-317
    • Di Lorenzo, G.1    Autorino, R.2    De Laurentiis, M.3
  • 52
    • 0029878436 scopus 로고    scopus 로고
    • Phase II study of the oral cyclophosphamide and oral etoposide combination in hormone-refractory prostate carcinoma patients
    • Maulard-Durdux C., Dufour B., Hennequin C., et al. Phase II study of the oral cyclophosphamide and oral etoposide combination in hormone-refractory prostate carcinoma patients. Cancer 1996, 77:1144-1148.
    • (1996) Cancer , vol.77 , pp. 1144-1148
    • Maulard-Durdux, C.1    Dufour, B.2    Hennequin, C.3
  • 53
    • 79961129887 scopus 로고    scopus 로고
    • Clinical outcome of patients with docetaxel-resistant hormone-refractory prostate cancer treated with second-line cyclophosphamide-based metronomic chemotherapy
    • Nelius T., Klatte T., de Riese W., Haynes A., Filleur S. Clinical outcome of patients with docetaxel-resistant hormone-refractory prostate cancer treated with second-line cyclophosphamide-based metronomic chemotherapy. Med Oncol 2009.
    • (2009) Med Oncol
    • Nelius, T.1    Klatte, T.2    de Riese, W.3    Haynes, A.4    Filleur, S.5
  • 54
    • 0034654510 scopus 로고    scopus 로고
    • Oral estramustine and cyclophosphamide in patients with metastatic hormone refractory prostate carcinoma: a phase II study
    • Bracarda S., Tonato M., Rosi P., et al. Oral estramustine and cyclophosphamide in patients with metastatic hormone refractory prostate carcinoma: a phase II study. Cancer 2000, 88:1438-1444.
    • (2000) Cancer , vol.88 , pp. 1438-1444
    • Bracarda, S.1    Tonato, M.2    Rosi, P.3
  • 55
    • 0141958313 scopus 로고    scopus 로고
    • Metronomic therapy with cyclophosphamide and dexamethasone for prostate carcinoma
    • Glode L.M., Barqawi A., Crighton F., Crawford E.D., Kerbel R. Metronomic therapy with cyclophosphamide and dexamethasone for prostate carcinoma. Cancer 2003, 98:1643-1648.
    • (2003) Cancer , vol.98 , pp. 1643-1648
    • Glode, L.M.1    Barqawi, A.2    Crighton, F.3    Crawford, E.D.4    Kerbel, R.5
  • 56
    • 0141958312 scopus 로고    scopus 로고
    • Phase II trial of oral cyclophosphamide, prednisone, and diethylstilbestrol for androgen-independent prostate carcinoma
    • Hellerstedt B., Pienta K.J., Redman B.G., et al. Phase II trial of oral cyclophosphamide, prednisone, and diethylstilbestrol for androgen-independent prostate carcinoma. Cancer 2003, 98:1603-1610.
    • (2003) Cancer , vol.98 , pp. 1603-1610
    • Hellerstedt, B.1    Pienta, K.J.2    Redman, B.G.3
  • 57
    • 34248190133 scopus 로고    scopus 로고
    • Low dose metronomic oral cyclophosphamide for hormone resistant prostate cancer: a phase II study
    • discussion 40
    • Lord R., Nair S., Schache A., et al. Low dose metronomic oral cyclophosphamide for hormone resistant prostate cancer: a phase II study. J Urol 2007, 177:2136-2140. discussion 40.
    • (2007) J Urol , vol.177 , pp. 2136-2140
    • Lord, R.1    Nair, S.2    Schache, A.3
  • 58
    • 5344266706 scopus 로고    scopus 로고
    • Oral low-dose cyclophosphamide in metastatic hormone refractory prostate cancer (MHRPC)
    • Nicolini A., Mancini P., Ferrari P., et al. Oral low-dose cyclophosphamide in metastatic hormone refractory prostate cancer (MHRPC). Biomed Pharmacother 2004, 58:447-450.
    • (2004) Biomed Pharmacother , vol.58 , pp. 447-450
    • Nicolini, A.1    Mancini, P.2    Ferrari, P.3
  • 59
    • 17744367405 scopus 로고    scopus 로고
    • Oral combination of cyclophosphamide, uracil plus tegafur and estramustine for hormone-refractory prostate cancer
    • Nishimura K., Nonomura N., Ono Y., et al. Oral combination of cyclophosphamide, uracil plus tegafur and estramustine for hormone-refractory prostate cancer. Oncology 2001, 60:49-54.
    • (2001) Oncology , vol.60 , pp. 49-54
    • Nishimura, K.1    Nonomura, N.2    Ono, Y.3
  • 60
    • 0027319154 scopus 로고
    • Cyclophosphamide, methotrexate, and 5-fluorouracil in the treatment of metastatic prostate cancer. A Southwest Oncology Group study
    • Wozniak A.J., Blumenstein B.A., Crawford E.D., et al. Cyclophosphamide, methotrexate, and 5-fluorouracil in the treatment of metastatic prostate cancer. A Southwest Oncology Group study. Cancer 1993, 71:3975-3978.
    • (1993) Cancer , vol.71 , pp. 3975-3978
    • Wozniak, A.J.1    Blumenstein, B.A.2    Crawford, E.D.3
  • 61
    • 0021257608 scopus 로고
    • Criteria for evaluating patient responses to treatment modalities for prostatic cancer
    • Slack N.H., Murphy G.P. Criteria for evaluating patient responses to treatment modalities for prostatic cancer. Urol Clin North Am 1984, 11:337-342.
    • (1984) Urol Clin North Am , vol.11 , pp. 337-342
    • Slack, N.H.1    Murphy, G.P.2
  • 62
    • 0032747375 scopus 로고    scopus 로고
    • Eligibility and response guidelines for phase II clinical trials in androgen-independent prostate cancer: recommendations from the Prostate-Specific Antigen Working Group
    • Bubley G.J., Carducci M., Dahut W., et al. Eligibility and response guidelines for phase II clinical trials in androgen-independent prostate cancer: recommendations from the Prostate-Specific Antigen Working Group. J Clin Oncol 1999, 17:3461-3467.
    • (1999) J Clin Oncol , vol.17 , pp. 3461-3467
    • Bubley, G.J.1    Carducci, M.2    Dahut, W.3
  • 63
    • 56249147452 scopus 로고    scopus 로고
    • The role of doxorubicin and epirubicin in the treatment of patients with metastatic hormone-refractory prostate cancer
    • Petrioli R., Fiaschi A.I., Francini E., Pascucci A., Francini G. The role of doxorubicin and epirubicin in the treatment of patients with metastatic hormone-refractory prostate cancer. Cancer Treat Rev 2008, 34:710-718.
    • (2008) Cancer Treat Rev , vol.34 , pp. 710-718
    • Petrioli, R.1    Fiaschi, A.I.2    Francini, E.3    Pascucci, A.4    Francini, G.5
  • 64
    • 0013092576 scopus 로고    scopus 로고
    • The evolving role of estrogen therapy in prostate cancer
    • Oh W.K. The evolving role of estrogen therapy in prostate cancer. Clin Prostate Cancer 2002, 1:81-89.
    • (2002) Clin Prostate Cancer , vol.1 , pp. 81-89
    • Oh, W.K.1
  • 65
    • 77956363740 scopus 로고    scopus 로고
    • Clinical outcome of patients with docetaxel-resistant hormone-refractory prostate cancer treated with second-line cyclophosphamide-based metronomic chemotherapy
    • Nelius T., Klatte T., de Riese W., Haynes A., Filleur S. Clinical outcome of patients with docetaxel-resistant hormone-refractory prostate cancer treated with second-line cyclophosphamide-based metronomic chemotherapy. Med Oncol 2010, 27:363-367.
    • (2010) Med Oncol , vol.27 , pp. 363-367
    • Nelius, T.1    Klatte, T.2    de Riese, W.3    Haynes, A.4    Filleur, S.5
  • 66
    • 73949098659 scopus 로고    scopus 로고
    • Multinational, double-blind, phase III study of prednisone and either satraplatin or placebo in patients with castrate-refractory prostate cancer progressing after prior chemotherapy: the SPARC trial
    • Sternberg C.N., Petrylak D.P., Sartor O., et al. Multinational, double-blind, phase III study of prednisone and either satraplatin or placebo in patients with castrate-refractory prostate cancer progressing after prior chemotherapy: the SPARC trial. J Clin Oncol 2009, 27:5431-5438.
    • (2009) J Clin Oncol , vol.27 , pp. 5431-5438
    • Sternberg, C.N.1    Petrylak, D.P.2    Sartor, O.3
  • 67
    • 33947610197 scopus 로고    scopus 로고
    • Double-blinded randomized study of high-dose calcitriol plus docetaxel compared with placebo plus docetaxel in androgen-independent prostate cancer: a report from the ASCENT Investigators
    • Beer T.M., Ryan C.W., Venner P.M., et al. Double-blinded randomized study of high-dose calcitriol plus docetaxel compared with placebo plus docetaxel in androgen-independent prostate cancer: a report from the ASCENT Investigators. J Clin Oncol 2007, 25:669-674.
    • (2007) J Clin Oncol , vol.25 , pp. 669-674
    • Beer, T.M.1    Ryan, C.W.2    Venner, P.M.3
  • 68
    • 77956542827 scopus 로고    scopus 로고
    • Cabazitaxel or mitoxantrone with prednisone in patients with metastatic castration-resistant prostate cancer (mCRPC) previously treated with docetaxel: Final results of a multinational phase III trial (TROPIC)
    • [abstr 4508]
    • Sartor A.C., Oudard S., Ozguroglu M., Hansen S., Machiels J., Shen L., et al. Cabazitaxel or mitoxantrone with prednisone in patients with metastatic castration-resistant prostate cancer (mCRPC) previously treated with docetaxel: Final results of a multinational phase III trial (TROPIC). J Clin Oncol 2010, 28(Suppl.):15s. [abstr 4508].
    • (2010) J Clin Oncol , vol.28 , Issue.SUPPL.
    • Sartor, A.C.1    Oudard, S.2    Ozguroglu, M.3    Hansen, S.4    Machiels, J.5    Shen, L.6
  • 69
    • 77952105685 scopus 로고    scopus 로고
    • Antitumour activity of MDV3100 in castration-resistant prostate cancer: a phase 1-2 study
    • Scher H.I., Beer T.M., Higano C.S., et al. Antitumour activity of MDV3100 in castration-resistant prostate cancer: a phase 1-2 study. Lancet 2010, 375:1437-1446.
    • (2010) Lancet , vol.375 , pp. 1437-1446
    • Scher, H.I.1    Beer, T.M.2    Higano, C.S.3
  • 70
    • 2942615257 scopus 로고    scopus 로고
    • The anti-angiogenic basis of metronomic chemotherapy
    • Kerbel R.S., Kamen B.A. The anti-angiogenic basis of metronomic chemotherapy. Nat Rev Cancer 2004, 4:423-436.
    • (2004) Nat Rev Cancer , vol.4 , pp. 423-436
    • Kerbel, R.S.1    Kamen, B.A.2
  • 71
    • 3042523515 scopus 로고    scopus 로고
    • Assessing tumor angiogenesis: increased circulating VE-cadherin RNA in patients with cancer indicates viability of circulating endothelial cells
    • Rabascio C., Muratori E., Mancuso P., et al. Assessing tumor angiogenesis: increased circulating VE-cadherin RNA in patients with cancer indicates viability of circulating endothelial cells. Cancer Res 2004, 64:4373-4377.
    • (2004) Cancer Res , vol.64 , pp. 4373-4377
    • Rabascio, C.1    Muratori, E.2    Mancuso, P.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.