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Volumn 33, Issue 9, 2013, Pages 3543-3552

Mitochondrial DNA damage is uncommon in cancer but can promote aggressive behaviour

Author keywords

Carcinogenesis; DNA repair; Metastasis; Mitochondrial DNA; Review

Indexed keywords

CELL NUCLEUS DNA; CIRCULAR DNA; CRE RECOMBINASE; CYTOCHROME B; CYTOCHROME C OXIDASE; GLUTATHIONE PEROXIDASE; HYPOXIA INDUCIBLE FACTOR 1; MITOCHONDRIAL DNA; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE; RIBOSOME RNA; TRANSFER RNA;

EID: 84885014085     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (15)

References (88)
  • 2
    • 0001221508 scopus 로고
    • On respiratory impairment in cancer cells
    • Warburg O: On respiratory impairment in cancer cells. Science 124(3215): 269-270, 1956.
    • (1956) Science , vol.124 , Issue.3215 , pp. 269-270
    • Warburg, O.1
  • 4
    • 24744442376 scopus 로고    scopus 로고
    • Mitochondrial DNA G10398A polymorphism and invasive breast cancer in African-American women
    • Canter JA, Kallianpur AR, Parl FF and Millikan RC: Mitochondrial DNA G10398A polymorphism and invasive breast cancer in African-American women. Cancer Res 65(17): 8028-8033, 2005.
    • (2005) Cancer Res , vol.65 , Issue.17 , pp. 8028-8033
    • Canter, J.A.1    Kallianpur, A.R.2    Parl, F.F.3    Millikan, R.C.4
  • 5
    • 33947373403 scopus 로고    scopus 로고
    • Mitochondrial DNA G10398A polymorphism imparts maternal haplogroup N a risk for breast and esophageal cancer
    • Darvishi K, Sharma S, Bhat AK, Rai E and Bamezai RN: Mitochondrial DNA G10398A polymorphism imparts maternal haplogroup N a risk for breast and esophageal cancer. Cancer Lett 249(2): 249-255, 2007.
    • (2007) Cancer Lett , vol.249 , Issue.2 , pp. 249-255
    • Darvishi, K.1    Sharma, S.2    Bhat, A.K.3    Rai, E.4    Bamezai, R.N.5
  • 6
    • 52649175410 scopus 로고    scopus 로고
    • Mitochondrial DNA variant interactions modify breast cancer risk
    • Covarrubias D, Bai RK, Wong LJ and Leal SM: Mitochondrial DNA variant interactions modify breast cancer risk. J Hum Genet 53(10): 924-928, 2008.
    • (2008) J Hum Genet , vol.53 , Issue.10 , pp. 924-928
    • Covarrubias, D.1    Bai, R.K.2    Wong, L.J.3    Leal, S.M.4
  • 9
    • 0037180245 scopus 로고    scopus 로고
    • Accumulation of mitochondrial DNA mutations in ageing, cancer, and mitochondrial disease: Is there a common mechanism?
    • Chinnery PF, Samuels DC, Elson J and Turnbull DM: Accumulation of mitochondrial DNA mutations in ageing, cancer, and mitochondrial disease: Is there a common mechanism? Lancet 360(9342): 1323-1325, 2002.
    • (2002) Lancet , vol.360 , Issue.9342 , pp. 1323-1325
    • Chinnery, P.F.1    Samuels, D.C.2    Elson, J.3    Turnbull, D.M.4
  • 10
    • 0037112431 scopus 로고    scopus 로고
    • Extensive somatic mitochondrial mutations in primary prostate cancer using laser capture microdissection
    • Chen JZ, Gokden N, Greene GF, Mukunyadzi P and Kadlubar FF: Extensive somatic mitochondrial mutations in primary prostate cancer using laser capture microdissection. Cancer Res 62(22): 6470-6474, 2002.
    • (2002) Cancer Res , vol.62 , Issue.22 , pp. 6470-6474
    • Chen, J.Z.1    Gokden, N.2    Greene, G.F.3    Mukunyadzi, P.4    Kadlubar, F.F.5
  • 11
    • 0042387705 scopus 로고    scopus 로고
    • Phylogeny of east asian mitochondrial DNA lineages inferred from complete sequences
    • Kong QP, Yao YG, Sun C, Bandelt HJ, Zhu CL and Zhang YP: Phylogeny of east asian mitochondrial DNA lineages inferred from complete sequences. Am J Hum Genet 73(3): 671-676, 2003.
    • (2003) Am J Hum Genet , vol.73 , Issue.3 , pp. 671-676
    • Kong, Q.P.1    Yao, Y.G.2    Sun, C.3    Bandelt, H.J.4    Zhu, C.L.5    Zhang, Y.P.6
  • 14
    • 28444447123 scopus 로고    scopus 로고
    • A critical reassessment of the role of mitochondria in tumorigenesis
    • Salas A, Yao Y, Macaulay V, Vega A, Carracedo A and Bandelt H: A critical reassessment of the role of mitochondria in tumorigenesis. PLoS Medicine 2(11): 1158-1166, 2005.
    • (2005) PLoS Medicine , vol.2 , Issue.11 , pp. 1158-1166
    • Salas, A.1    Yao, Y.2    Macaulay, V.3    Vega, A.4    Carracedo, A.5    Bandelt, H.6
  • 16
    • 0035501563 scopus 로고    scopus 로고
    • Detection of mitochondrial DNA alterations in primary tumors and corresponding serum of colorectal cancer patients
    • Hibi K, Nakayama H, Yamazaki T, Takase T, Taguchi M, Kasai Y, Ito K, Akiyama S and Nakao A: Detection of mitochondrial DNA alterations in primary tumors and corresponding serum of colorectal cancer patients. Int J Cancer 94(3): 429-431, 2001.
    • (2001) Int J Cancer , vol.94 , Issue.3 , pp. 429-431
    • Hibi, K.1    Nakayama, H.2    Yamazaki, T.3    Takase, T.4    Taguchi, M.5    Kasai, Y.6    Ito, K.7    Akiyama, S.8    Nakao, A.9
  • 19
    • 1542345767 scopus 로고    scopus 로고
    • Somatic mutations in the D-loop and decrease in the copy number of mitochondrial DNA in human hepatocellular carcinoma
    • Lee H, Li S, Lin J, Wu C, Yeh D and Wei Y: Somatic mutations in the D-loop and decrease in the copy number of mitochondrial DNA in human hepatocellular carcinoma. Mutat Res 547(1-2): 71-78, 2004.
    • (2004) Mutat Res , vol.547 , Issue.1-2 , pp. 71-78
    • Lee, H.1    Li, S.2    Lin, J.3    Wu, C.4    Yeh, D.5    Wei, Y.6
  • 20
    • 76349101416 scopus 로고    scopus 로고
    • Somatic mutations of mitochondrial genome in hepatocellular carcinoma
    • Yin P, Wu C, Lin J, Chi C, Wei Y and Lee H: Somatic mutations of mitochondrial genome in hepatocellular carcinoma. Mitochondrion 10(2): 174-182, 2010.
    • (2010) Mitochondrion , vol.10 , Issue.2 , pp. 174-182
    • Yin, P.1    Wu, C.2    Lin, J.3    Chi, C.4    Wei, Y.5    Lee, H.6
  • 21
    • 13144295901 scopus 로고    scopus 로고
    • Control region mutations and the 'common deletion' are frequent in the mitochondrial DNA of patients with esophageal squamous cell carcinoma
    • Abnet CC, Huppi K, Carrera A, Armistead D, McKenney K, Hu N, Tang ZZ, Taylor PR and Dawsey SM: Control region mutations and the 'common deletion' are frequent in the mitochondrial DNA of patients with esophageal squamous cell carcinoma. BMC Cancer 4: 30, 2004.
    • (2004) BMC Cancer , vol.4 , pp. 30
    • Abnet, C.C.1    Huppi, K.2    Carrera, A.3    Armistead, D.4    McKenney, K.5    Hu, N.6    Tang, Z.Z.7    Taylor, P.R.8    Dawsey, S.M.9
  • 25
    • 84861324017 scopus 로고    scopus 로고
    • Frequent occurrence of mitochondrial DNA mutations in Barrett's metaplasia without the presence of dysplasia
    • Lee S, Han M, Lee K, Back S, Hwang D, Kim H, Shin J, Suh S, Ryang D, Kim H and Shin M: Frequent occurrence of mitochondrial DNA mutations in Barrett's metaplasia without the presence of dysplasia. PLoS ONE 7(5): e37571, 2012.
    • (2012) PLoS ONE , vol.7 , Issue.5
    • Lee, S.1    Han, M.2    Lee, K.3    Back, S.4    Hwang, D.5    Kim, H.6    Shin, J.7    Suh, S.8    Ryang, D.9    Kim, H.10    Shin, M.11
  • 26
    • 0038281403 scopus 로고    scopus 로고
    • Mitochondrial DNA mutations in patients with myelodysplastic syndromes
    • Shin MG, Kajigaya S, Levin BC and Young NS: Mitochondrial DNA mutations in patients with myelodysplastic syndromes. Blood 101(8): 3118-3125, 2003.
    • (2003) Blood , vol.101 , Issue.8 , pp. 3118-3125
    • Shin, M.G.1    Kajigaya, S.2    Levin, B.C.3    Young, N.S.4
  • 27
    • 1542615082 scopus 로고    scopus 로고
    • Comprehensive scanning of somatic mitochondrial DNA alterations in acute leukemia developing from myelodysplastic syndromes
    • Linnartz B, Anglmayer R and Zanssen S: Comprehensive scanning of somatic mitochondrial DNA alterations in acute leukemia developing from myelodysplastic syndromes. Cancer Res 64(6): 1966-1971, 2004.
    • (2004) Cancer Res , vol.64 , Issue.6 , pp. 1966-1971
    • Linnartz, B.1    Anglmayer, R.2    Zanssen, S.3
  • 29
    • 0035882532 scopus 로고    scopus 로고
    • High frequency of mitochondrial DNA mutations in glioblastoma multiforme identified by direct sequence comparison to blood samples
    • Kirches E, Krause G, Warich-Kirches M, Weis S, Schneider T, Meyer-Puttlitz B, Mawrin C and Dietzmann K: High frequency of mitochondrial DNA mutations in glioblastoma multiforme identified by direct sequence comparison to blood samples. Int J Cancer 93(4): 534-538, 2001.
    • (2001) Int J Cancer , vol.93 , Issue.4 , pp. 534-538
    • Kirches, E.1    Krause, G.2    Warich-Kirches, M.3    Weis, S.4    Schneider, T.5    Meyer-Puttlitz, B.6    Mawrin, C.7    Dietzmann, K.8
  • 31
    • 0000825475 scopus 로고
    • The absence of a pyrimidine dimer repair mechanism in mammalian mitochondria
    • Clayton DA, Doda JN and Friedberg EC: The absence of a pyrimidine dimer repair mechanism in mammalian mitochondria. Proc Natl Acad Sci USA 71(7): 2777-2781, 1974.
    • (1974) Proc Natl Acad Sci USA , vol.71 , Issue.7 , pp. 2777-2781
    • Clayton, D.A.1    Doda, J.N.2    Friedberg, E.C.3
  • 32
    • 0026493929 scopus 로고
    • Repair of mitochondrial DNA after various types of DNA damage in Chinese hamster ovary cells
    • LeDoux SP, Wilson GL, Beecham EJ, Stevnsner T, Wassermann K and Bohr VA: Repair of mitochondrial DNA after various types of DNA damage in Chinese hamster ovary cells. Carcinogenesis 13(11): 1967-1973, 1992.
    • (1992) Carcinogenesis , vol.13 , Issue.11 , pp. 1967-1973
    • Ledoux, S.P.1    Wilson, G.L.2    Beecham, E.J.3    Stevnsner, T.4    Wassermann, K.5    Bohr, V.A.6
  • 33
    • 0027438888 scopus 로고
    • Repair of oxidative damage within the mitochondrial DNA of RINr 38 cells
    • Driggers WJ, LeDoux SP and Wilson GL: Repair of oxidative damage within the mitochondrial DNA of RINr 38 cells. J Biol Chem 268(29): 22042-22045, 1993.
    • (1993) J Biol Chem , vol.268 , Issue.29 , pp. 22042-22045
    • Driggers, W.J.1    Ledoux, S.P.2    Wilson, G.L.3
  • 34
    • 0025116342 scopus 로고
    • Mechanism of the neurotoxicity of MPTP: An update
    • Singer TP and Ramsay RR: Mechanism of the neurotoxicity of MPTP: An update. FEBS Lett 274(1-2): 1-8, 1990.
    • (1990) FEBS Lett , vol.274 , Issue.1-2 , pp. 1-8
    • Singer, T.P.1    Ramsay, R.R.2
  • 35
    • 0019306621 scopus 로고
    • Mitochondrial DNA is a major cellular target for a dihydrodiol-epoxide derivative of benzo[a]pyrene
    • Backer JM, Weinstein IB: Mitochondrial DNA is a major cellular target for a dihydrodiol-epoxide derivative of benzo[a]pyrene. Science 209(4453): 297-299, 1980.
    • (1980) Science , vol.209 , Issue.4453 , pp. 297-299
    • Backer, J.M.1    Weinstein, I.B.2
  • 36
    • 0020026483 scopus 로고
    • Preferential attack of mitochondrial DNA by aflatoxin B1 during hepatocarcinogenesis
    • Niranjan BG, Bhat NK and Avadhani NG: Preferential attack of mitochondrial DNA by aflatoxin B1 during hepatocarcinogenesis. Science 215(4528): 73-75, 1982.
    • (1982) Science , vol.215 , Issue.4528 , pp. 73-75
    • Niranjan, B.G.1    Bhat, N.K.2    Avadhani, N.G.3
  • 37
    • 0030881789 scopus 로고    scopus 로고
    • Repair of oxidative damage to nuclear and mitochondrial DNA in mammalian cells
    • Croteau DL and Bohr VA: Repair of oxidative damage to nuclear and mitochondrial DNA in mammalian cells. J Biol Chem 272(41): 25409-25412, 1997.
    • (1997) J Biol Chem , vol.272 , Issue.41 , pp. 25409-25412
    • Croteau, D.L.1    Bohr, V.A.2
  • 39
    • 0029911367 scopus 로고    scopus 로고
    • Mammalian mitochondria possess homologous DNA recombination activity
    • Thyagarajan B, Padua RA and Campbell C: Mammalian mitochondria possess homologous DNA recombination activity. J Biol Chem 271(44): 27536-27543, 1996.
    • (1996) J Biol Chem , vol.271 , Issue.44 , pp. 27536-27543
    • Thyagarajan, B.1    Padua, R.A.2    Campbell, C.3
  • 40
    • 84858199617 scopus 로고    scopus 로고
    • Mitochondrial genome maintenance: Roles for nuclear nonhomologous end-joining proteins in Saccharomyces cerevisiae
    • Kalifa L, Quintana DF, Schiraldi LK, Phadnis N, Coles GL, Sia RA and Sia EA: Mitochondrial genome maintenance: Roles for nuclear nonhomologous end-joining proteins in Saccharomyces cerevisiae. Genetics 190(3): 951-964, 2012.
    • (2012) Genetics , vol.190 , Issue.3 , pp. 951-964
    • Kalifa, L.1    Quintana, D.F.2    Schiraldi, L.K.3    Phadnis, N.4    Coles, G.L.5    Sia, R.A.6    Sia, E.A.7
  • 42
    • 0033566862 scopus 로고    scopus 로고
    • Mammalian mitochondrial extracts possess DNA end-binding activity
    • Coffey G, Lakshmipathy U and Campbell C: Mammalian mitochondrial extracts possess DNA end-binding activity: Nucleic Acids Res 27(16): 3348-3354, 1999.
    • (1999) Nucleic Acids Res , vol.27 , Issue.16 , pp. 3348-3354
    • Coffey, G.1    Lakshmipathy, U.2    Campbell, C.3
  • 43
    • 0034730598 scopus 로고    scopus 로고
    • High direct estimate of the mutation rate in the mitochondrial genome of Caenorhabditis elegans
    • Denver DR, Morris K, Lynch M, Vassilieva LL and Thomas WK: High direct estimate of the mutation rate in the mitochondrial genome of Caenorhabditis elegans. Science 289(5488): 2342-2344, 2000.
    • (2000) Science , vol.289 , Issue.5488 , pp. 2342-2344
    • Denver, D.R.1    Morris, K.2    Lynch, M.3    Vassilieva, L.L.4    Thomas, W.K.5
  • 44
    • 3943059570 scopus 로고    scopus 로고
    • High mutation rate and predominance of insertions in the Caenorhabditis elegans nuclear genome
    • Denver DR, Morris K, Lynch M and Thomas WK: High mutation rate and predominance of insertions in the Caenorhabditis elegans nuclear genome. Nature 430(7000): 679-682, 2004.
    • (2004) Nature , vol.430 , Issue.7000 , pp. 679-682
    • Denver, D.R.1    Morris, K.2    Lynch, M.3    Thomas, W.K.4
  • 47
    • 84875273810 scopus 로고    scopus 로고
    • New insights into the function and regulation of mitochondrial fission
    • Otera H, Ishihara N and Mihara K: New insights into the function and regulation of mitochondrial fission. Biochim Biophys Acta 1833(5): 1256-1268, 2013.
    • (2013) Biochim Biophys Acta , vol.1833 , Issue.5 , pp. 1256-1268
    • Otera, H.1    Ishihara, N.2    Mihara, K.3
  • 48
    • 0025313091 scopus 로고
    • Unexpected nonrandom mitochondrial DNA segregation in human cell hybrids
    • Shay JW and Ishii S: Unexpected nonrandom mitochondrial DNA segregation in human cell hybrids. Anticancer Res 10(2 A): 279-284, 1990.
    • (1990) Anticancer Res , vol.10 , Issue.2 A , pp. 279-284
    • Shay, J.W.1    Ishii, S.2
  • 49
    • 64549098628 scopus 로고    scopus 로고
    • A heteroplasmic, not homoplasmic, mitochondrial DNA mutation promotes tumorigenesis via alteration in reactive oxygen species generation and apoptosis
    • Park JS, Sharma LK, Li H, Xiang R, Holstein D, Wu J, Lechleiter J, Naylor SL, Deng JJ, Lu J and Bai Y: A heteroplasmic, not homoplasmic, mitochondrial DNA mutation promotes tumorigenesis via alteration in reactive oxygen species generation and apoptosis. Hum Mol Genet 18(9): 1578-1589, 2009.
    • (2009) Hum Mol Genet , vol.18 , Issue.9 , pp. 1578-1589
    • Park, J.S.1    Sharma, L.K.2    Li, H.3    Xiang, R.4    Holstein, D.5    Wu, J.6    Lechleiter, J.7    Naylor, S.L.8    Deng, J.J.9    Lu, J.10    Bai, Y.11
  • 50
    • 59449106196 scopus 로고    scopus 로고
    • Mitochondrial mutations contribute to HIF1α accumulation via increased reactive oxygen species and upregulated pyruvate dehydrogenase kinase 2 in head and neck squamous cell carcinoma
    • Sun W, Zhou S, Chang SS, McFate T, Verma A and Califano JA: Mitochondrial mutations contribute to HIF1α accumulation via increased reactive oxygen species and upregulated pyruvate dehydrogenase kinase 2 in head and neck squamous cell carcinoma. Clin Cancer Res 15(2): 476-484, 2009.
    • (2009) Clin Cancer Res , vol.15 , Issue.2 , pp. 476-484
    • Sun, W.1    Zhou, S.2    Chang, S.S.3    McFate, T.4    Verma, A.5    Califano, J.A.6
  • 51
    • 83455245373 scopus 로고    scopus 로고
    • Somatic alterations in mitochondrial DNA produce changes in cell growth and metabolism supporting a tumorigenic phenotype
    • Jandova J, Shi M, Norman KG, Stricklin GP and Sligh JE: Somatic alterations in mitochondrial DNA produce changes in cell growth and metabolism supporting a tumorigenic phenotype. Biochim Biophys Acta 1822(2): 293-300, 2012.
    • (2012) Biochim Biophys Acta , vol.1822 , Issue.2 , pp. 293-300
    • Jandova, J.1    Shi, M.2    Norman, K.G.3    Stricklin, G.P.4    Sligh, J.E.5
  • 55
    • 53449090706 scopus 로고    scopus 로고
    • "ROS-generating mitochondrial DNA mutations can regulate tumor cell metastasis"-a critical commentary
    • Zielonka J, Kalyanaraman B: "ROS-generating mitochondrial DNA mutations can regulate tumor cell metastasis"-a critical commentary. Free Radic Biol Med 45(9): 1217-1219, 2008.
    • (2008) Free Radic Biol Med , vol.45 , Issue.9 , pp. 1217-1219
    • Zielonka, J.1    Kalyanaraman, B.2
  • 59
    • 0033151863 scopus 로고    scopus 로고
    • Cell-by-cell scanning of whole mitochondrial genomes in aged human heart reveals a significant fraction of myocytes with clonally expanded deletions
    • Khrapko K, Bodyak N, Thilly WG, Van Orsouw NJ, Zhang X, Coller HA, Peris TT, Upton M, Vijg J and Wei JY: Cell-by-cell scanning of whole mitochondrial genomes in aged human heart reveals a significant fraction of myocytes with clonally expanded deletions. Nucleic Acids Res 27(11): 2434-2441, 1999.
    • (1999) Nucleic Acids Res , vol.27 , Issue.11 , pp. 2434-2441
    • Khrapko, K.1    Bodyak, N.2    Thilly, W.G.3    Van Orsouw, N.J.4    Zhang, X.5    Coller, H.A.6    Peris, T.T.7    Upton, M.8    Vijg, J.9    Wei, J.Y.10
  • 60
    • 84860553218 scopus 로고    scopus 로고
    • RecA-dependent DNA repair results in increased heteroplasmy of the Arabidopsis mitochondrial genome
    • Miller-Messmer M, Kuhn K, Bichara M, le Ret M, Imbault P and Gualberto JM: RecA-dependent DNA repair results in increased heteroplasmy of the Arabidopsis mitochondrial genome. Plant Physiol 159(1): 211-226, 2012.
    • (2012) Plant Physiol , vol.159 , Issue.1 , pp. 211-226
    • Miller-Messmer, M.1    Kuhn, K.2    Bichara, M.3    Le Ret, M.4    Imbault, P.5    Gualberto, J.M.6
  • 61
    • 84868192844 scopus 로고    scopus 로고
    • A RAD52-like singlestranded DNA binding protein affects mitochondrial DNA repair by recombination
    • Janicka S, Kühn K, Le Ret M, Bonnard G, Imbault P, Augustyniak H and Gualberto JM: A RAD52-like singlestranded DNA binding protein affects mitochondrial DNA repair by recombination. Plant J 72(3): 423-435, 2012.
    • (2012) Plant J , vol.72 , Issue.3 , pp. 423-435
    • Janicka, S.1    Kühn, K.2    Le Ret, M.3    Bonnard, G.4    Imbault, P.5    Augustyniak, H.6    Gualberto, J.M.7
  • 63
    • 50149097983 scopus 로고    scopus 로고
    • Hypoxia, HIF1 and glucose metabolism in the solid tumour
    • Denko NC: Hypoxia, HIF1 and glucose metabolism in the solid tumour. Nat Rev Cancer 8(9): 705-713, 2008.
    • (2008) Nat Rev Cancer , vol.8 , Issue.9 , pp. 705-713
    • Denko, N.C.1
  • 64
    • 0031032817 scopus 로고    scopus 로고
    • Mitochondrial DNA damage is more extensive and persists longer than nuclear DNA damage in human cells following oxidative stress
    • Yakes FM and Van Houten B: Mitochondrial DNA damage is more extensive and persists longer than nuclear DNA damage in human cells following oxidative stress. Proc Natl Acad Sci USA 94(2): 514-519, 1997.
    • (1997) Proc Natl Acad Sci USA , vol.94 , Issue.2 , pp. 514-519
    • Yakes, F.M.1    Van Houten, B.2
  • 66
    • 0025081437 scopus 로고
    • Mitochondrial DNA modulation of the anchorage-independent phenotype of transformed avian cells
    • Zinkewich-Peotti K, Parent M and Morais R: Mitochondrial DNA modulation of the anchorage-independent phenotype of transformed avian cells. Cancer Res 50(20): 6675-6682, 1990.
    • (1990) Cancer Res , vol.50 , Issue.20 , pp. 6675-6682
    • Zinkewich-Peotti, K.1    Parent, M.2    Morais, R.3
  • 67
    • 0026697079 scopus 로고
    • Recovery of the missing tumorigenicity in mitochondrial DNA-less HeLa cells by introduction of mitochondrial DNA from normal human cells
    • Hayashi J, Takemitsu M and Nonaka I: Recovery of the missing tumorigenicity in mitochondrial DNA-less HeLa cells by introduction of mitochondrial DNA from normal human cells. Somat Cell Mol Genet 18(2): 123-129, 1992.
    • (1992) Somat Cell Mol Genet , vol.18 , Issue.2 , pp. 123-129
    • Hayashi, J.1    Takemitsu, M.2    Nonaka, I.3
  • 68
    • 0030728737 scopus 로고    scopus 로고
    • Diminished tumorigenic phenotype after depletion of mitochondrial DNA
    • Cavalli LR, Varella-Garcia M and Liang BC: Diminished tumorigenic phenotype after depletion of mitochondrial DNA. Cell Growth Differ 8(11): 1189-1198, 1997.
    • (1997) Cell Growth Differ , vol.8 , Issue.11 , pp. 1189-1198
    • Cavalli, L.R.1    Varella-Garcia, M.2    Liang, B.C.3
  • 69
    • 0035957398 scopus 로고    scopus 로고
    • Increased in vivo apoptosis in cells lacking mitochondrial DNA gene expression
    • Wang J, Silva JP, Gustafsson CM, Rustin P and Larsson N: Increased in vivo apoptosis in cells lacking mitochondrial DNA gene expression. Proc Natl Acad Sci USA 98(7): 4038-4043, 2001.
    • (2001) Proc Natl Acad Sci USA , vol.98 , Issue.7 , pp. 4038-4043
    • Wang, J.1    Silva, J.P.2    Gustafsson, C.M.3    Rustin, P.4    Larsson, N.5
  • 70
    • 56449097919 scopus 로고    scopus 로고
    • Tumorigenic transformation of human breast epithelial cells induced by mitochondrial DNA depletion
    • Kulawiec M, Safina A, Desouki MM, Still I, Matsui S, Bakin A and Singh KK: Tumorigenic transformation of human breast epithelial cells induced by mitochondrial DNA depletion. Cancer Biol Ther 7(11): 1732-1743, 2008.
    • (2008) Cancer Biol Ther , vol.7 , Issue.11 , pp. 1732-1743
    • Kulawiec, M.1    Safina, A.2    Desouki, M.M.3    Still, I.4    Matsui, S.5    Bakin, A.6    Singh, K.K.7
  • 72
    • 45449088101 scopus 로고    scopus 로고
    • Mitochondrial DNA repair in aging and disease
    • Druzhyna NM, Wilson GL and LeDoux SP: Mitochondrial DNA repair in aging and disease. Mech Ageing Dev 129(7-8): 383-390, 2008.
    • (2008) Mech Ageing Dev , vol.129 , Issue.7-8 , pp. 383-390
    • Druzhyna, N.M.1    Wilson, G.L.2    Ledoux, S.P.3
  • 73
    • 13644267272 scopus 로고    scopus 로고
    • Mutation in mitochondrial complex i ND6 subunit is associated with defective response to hypoxia in human glioma cells
    • DeHaan C, Habibi-Nazhad B, Yan E, Salloum N, Parliament M and Allalunis-Turner J: Mutation in mitochondrial complex I ND6 subunit is associated with defective response to hypoxia in human glioma cells. Mol Cancer 3: 19, 2004.
    • (2004) Mol Cancer , vol.3 , pp. 19
    • Dehaan, C.1    Habibi-Nazhad, B.2    Yan, E.3    Salloum, N.4    Parliament, M.5    Allalunis-Turner, J.6
  • 75
    • 84885006108 scopus 로고    scopus 로고
    • Revised 20 June 2013. Last accessed 29 June
    • Lott M, Wallace D: Pathological mutations in tRNALeu. MITOMAP http://www.mitomap.org/pub/MITOMAP/mitomap figures/tRNAleu.pdf. Revised 20 June 2013. Last accessed 29 June 2013.
    • (2013) Pathological Mutations in TRNALeu
    • Lott, M.1    Wallace, D.2
  • 76
    • 84868294727 scopus 로고    scopus 로고
    • Genomic instability at the 13q31 locus and somatic mtDNA mutation in the D-loop site correlate with tumor aggressiveness in sporadic Brazilian breast cancer cases
    • dos Santos GC Jr., de Souza Góoes AC, de Vitto H, Moreira CC, Avvad E, Rumjanek FD and de Moura Gallo CV: Genomic instability at the 13q31 locus and somatic mtDNA mutation in the D-loop site correlate with tumor aggressiveness in sporadic Brazilian breast cancer cases. Clinics 67(10): 1181-1190, 2012.
    • (2012) Clinics , vol.67 , Issue.10 , pp. 1181-1190
    • Dos Santos Jr., G.C.1    De Souza Góoes, A.C.2    De Vitto, H.3    Moreira, C.C.4    Avvad, E.5    Rumjanek, F.D.6    De Moura Gallo, C.V.7
  • 77
    • 10244247903 scopus 로고    scopus 로고
    • Correlation between clinical characteristics and mitochondrial D-loop DNA mutations in hepatocellular carcinoma
    • Tamori A, Nishiguchi S, Nishikawa M, Kubo S, Koh N, Hirohashi K, Shiomi S and Inoue M: Correlation between clinical characteristics and mitochondrial D-loop DNA mutations in hepatocellular carcinoma. J Gastroenterol 39(11): 1063-1068, 2004.
    • (2004) J Gastroenterol , vol.39 , Issue.11 , pp. 1063-1068
    • Tamori, A.1    Nishiguchi, S.2    Nishikawa, M.3    Kubo, S.4    Koh, N.5    Hirohashi, K.6    Shiomi, S.7    Inoue, M.8
  • 79
    • 84858226929 scopus 로고    scopus 로고
    • Clinical significance of mitochondrial transcription factor A expression in patients with colorectal cancer
    • Nakayama Y, Yamauchi M, Minagawa N, Torigoe T, Izumi H, Kohno K and Yamaguchi K: Clinical significance of mitochondrial transcription factor A expression in patients with colorectal cancer. Oncol Rep 27(5): 1325-1330, 2012.
    • (2012) Oncol Rep , vol.27 , Issue.5 , pp. 1325-1330
    • Nakayama, Y.1    Yamauchi, M.2    Minagawa, N.3    Torigoe, T.4    Izumi, H.5    Kohno, K.6    Yamaguchi, K.7
  • 85
    • 33744783432 scopus 로고    scopus 로고
    • Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance
    • Fantin VR, St-Pierre J and Leder P: Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance. Cancer Cell 9(6): 425-434, 2006.
    • (2006) Cancer Cell , vol.9 , Issue.6 , pp. 425-434
    • Fantin, V.R.1    St-Pierre, J.2    Leder, P.3
  • 87
    • 0034682786 scopus 로고    scopus 로고
    • Reactive oxygen species generated at mitochondrial complex III stabilize hypoxia-inducible factor-1a during hypoxia: A mechanism of O2 sensing
    • Chandel NS, McClintock DS, Feliciano CE, Wood TM, Melendez JA, Rodriguez AM and Schumacker PT: Reactive oxygen species generated at mitochondrial complex III stabilize hypoxia-inducible factor-1a during hypoxia: A mechanism of O2 sensing. J Biol Chem 275(33): 25130-25138, 2000.
    • (2000) J Biol Chem , vol.275 , Issue.33 , pp. 25130-25138
    • Chandel, N.S.1    McClintock, D.S.2    Feliciano, C.E.3    Wood, T.M.4    Melendez, J.A.5    Rodriguez, A.M.6    Schumacker, P.T.7
  • 88
    • 76349095132 scopus 로고    scopus 로고
    • Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics
    • Semenza GL: Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics. Oncogene 29(5): 625-634, 2010.
    • (2010) Oncogene , vol.29 , Issue.5 , pp. 625-634
    • Semenza, G.L.1


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