XPC silencing in normal human keratinocytes triggers metabolic alterations that drive the formation of squamous cell carcinomas

Journal of Clinical Investigation

Volumn 121, Issue 1, 2011, Pages 195-211

  Rezvani, Hamid Reza ^a,b,c   Kim, Arianna L ^a   Rossignol, Rodrigue ^b,c   Ali, Nsrein ^b,c   Daly, Meaghan ^a   Mahfouf, Walid ^b,c   Bellance, Nadège ^b,c   Taïeb, Alain ^b,c,d   De Verneuil, Hubert ^b,c   Mazurier, Frédéric ^b,c   Bickers, David R ^a  

^a Columbia University ^*  (United States)

^b INSERM   (France)

^c UNIVERSITÉ DE BORDEAUX   (France)

^d HÔPITAL SAINT ANDRÉ   (France)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; DNA DEPENDENT PROTEIN KINASE; MITOCHONDRIAL DNA; PROTEIN KINASE B; PROTEIN KINASE B 1; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 1; UNCLASSIFIED DRUG; XERODERMA PIGMENTOSUM GROUP C PROTEIN;

ARTICLE; CANCER CELL CULTURE; CANCER INCIDENCE; CELL METABOLISM; CONTROLLED STUDY; DISEASE ASSOCIATION; DNA DAMAGE; ENZYME ACTIVATION; ENZYME ACTIVITY; EXCISION REPAIR; GENE DELETION; GENE MUTATION; GENE SILENCING; GENETIC TRANSDUCTION; GENOMIC INSTABILITY; GENOMICS; GLYCOLYSIS; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; KERATINOCYTE; LENTIVIRINAE; MALIGNANT TRANSFORMATION; MITOCHONDRIAL RESPIRATION; OXIDATIVE PHOSPHORYLATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; SKIN CANCER; SKIN CARCINOGENESIS; SQUAMOUS CELL CARCINOMA; XERODERMA PIGMENTOSUM;

ANIMALS; CARCINOMA, SQUAMOUS CELL; CELL PROLIFERATION; CELL TRANSFORMATION, NEOPLASTIC; DNA DAMAGE; DNA REPAIR; DNA, MITOCHONDRIAL; DNA-BINDING PROTEINS; ENERGY METABOLISM; GENE KNOCKDOWN TECHNIQUES; GENE SILENCING; HUMANS; KERATINOCYTES; MICE; MICE, INBRED NOD; MICE, SCID; MITOCHONDRIA; MODELS, BIOLOGICAL; MUTATION; NADPH OXIDASE; PROTO-ONCOGENE PROTEINS C-AKT; REACTIVE OXYGEN SPECIES; SKIN NEOPLASMS; TRANSPLANTATION, HETEROLOGOUS;

EID: 78650935572     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI40087     Document Type: Article

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