MicroRNAs as pharmacological targets in endothelial cell function and dysfunction

Pharmacological Research

Volumn 75, Issue , 2013, Pages 15-27

  Chamorro Jorganes, Aránzazu ^a   Araldi, Elisa ^a   Suárez, Yajaira ^a  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Endothelial cell dysfunction; Endothelial cells; MicroRNA therapeutics; MicroRNAs; Vascular disease

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MICRORNA; MICRORNA 10A; MICRORNA 125B; MICRORNA 126; MICRORNA 15; MICRORNA 16; MICRORNA 17; MICRORNA 181B; MICRORNA 20; MICRORNA 210; MICRORNA 217; MICRORNA 221; MICRORNA 222; MICRORNA 23; MICRORNA 24; MICRORNA 27; MICRORNA 424; MICRORNA 503; MICRORNA ANTIBODY; MIRAVIRSEN; RNA ANTIBODY; UNCLASSIFIED DRUG;

ANGIOGENESIS; APOPTOSIS; ARTICLE; BLOOD FLOW; BLOOD VESSEL TONE; CELL AGING; CELL CYCLE PROGRESSION; CELL DIFFERENTIATION; CELL FUNCTION; CELL MIGRATION; CELL PROLIFERATION; DOWN REGULATION; DRUG EFFICACY; DRUG RESPONSE; ENDOTHELIAL DYSFUNCTION; ENDOTHELIUM CELL; GENE CLUSTER; GENE EXPRESSION; GENE FUNCTION; GENE TARGETING; HEPATITIS C; HUMAN; INFLAMMATION; ISCHEMIA; LEUKOCYTE; LIMB ISCHEMIA; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; RNA STABILITY; TUMOR GROWTH; UPREGULATION; VASCULAR DISEASE;

ENDOTHELIAL CELL DYSFUNCTION; ENDOTHELIAL CELLS; MICRORNA THERAPEUTICS; MICRORNAS; VASCULAR DISEASE;

ANIMALS; CARDIOVASCULAR DISEASES; CELL DIFFERENTIATION; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; GENE EXPRESSION REGULATION; GENE TARGETING; GENETIC THERAPY; HEMODYNAMICS; HUMANS; MICRORNAS;

EID: 84884817128     PISSN: 10436618     EISSN: 10961186     Source Type: Journal    
DOI: 10.1016/j.phrs.2013.04.002     Document Type: Review

References (228)

1. A.P. Fishman Endothelium: a distributed organ of diverse capabilities Annals of the New York Academy of Sciences 401 1982 1 8
2. J. Arnout, M.F. Hoylaerts, and H.R. Lijnen Haemostasis Handbook of Experimental Pharmacology 2006 1 41
3. G. Bazzoni, and E. Dejana Endothelial cell-to-cell junctions: molecular organization and role in vascular homeostasis Physiological Reviews 84 2004 869 901 (Pubitemid 38823769)
4. R. Busse, and I. Fleming Vascular endothelium and blood flow Handbook of Experimental Pharmacology 2006 43 78
5. D.B. Cines, E.S. Pollak, C.A. Buck, J. Loscalzo, G.A. Zimmerman, and R.P. McEver Endothelial cells in physiology and in the pathophysiology of vascular disorders Blood 91 1998 3527 3561 (Pubitemid 28225719)
6. A.P. Hall Review of the pericyte during angiogenesis and its role in cancer and diabetic retinopathy Toxicologic Pathology 34 2006 763 775
7. C. Michiels Endothelial cell functions Journal of Cellular Physiology 196 2003 430 443 (Pubitemid 36927738)
8. R.D. Minshall, and A.B. Malik Transport across the endothelium: regulation of endothelial permeability Handbook of Experimental Pharmacology 2006 107 144
9. S. Moncada, and E.A. Higgs Nitric oxide and the vascular endothelium Handbook of Experimental Pharmacology 2006 213 254
10. J.S. Pober, and W.C. Sessa Evolving functions of endothelial cells in inflammation Nature Reviews Immunology 7 2007 803 815 (Pubitemid 47480307)
11. J. Davignon, and P. Ganz Role of endothelial dysfunction in atherosclerosis Circulation 109 2004 III27 III32
12. G.K. Kolluru, S.C. Bir, and C.G. Kevil Endothelial dysfunction and diabetes: effects on angiogenesis, vascular remodeling, and wound healing International Journal of Vascular Medicine 2012 2012 918267
13. J.D. Pearson Normal endothelial cell function Lupus 9 2000 183 188 (Pubitemid 30199260)
14. J.S. Pober, and R.S. Cotran The role of endothelial cells in inflammation Transplantation 50 1990 537 544 (Pubitemid 20358517)
15. B.E. Sumpio, J.T. Riley, and A. Dardik Cells in focus: endothelial cell International Journal of Biochemistry and Cell Biology 34 2002 1508 1512
16. S. Verma, M.R. Buchanan, and T.J. Anderson Endothelial function testing as a biomarker of vascular disease Circulation 108 2003 2054 2059 (Pubitemid 37337577)
17. M.S. Goligorsky Endothelial cell dysfunction: can't live with it, how to live without it American Journal of Physiology. Renal Physiology 288 2005 F871 F880
18. E. O'Riordan, J. Chen, S.V. Brodsky, I. Smirnova, H. Li, and M.S. Goligorsky Endothelial cell dysfunction: the syndrome in making Kidney International 67 2005 1654 1658 (Pubitemid 40577693)
19. M.A. Gimbrone Jr., and G. Garcia-Cardena Vascular endothelium, hemodynamics, and the pathobiology of atherosclerosis Cardiovascular Pathology: The Official Journal of the Society for Cardiovascular Pathology 23 2013 9 15
20. J. Folkman Angiogenesis in cancer, vascular, rheumatoid and other disease Nature Medicine 1 1995 27 31
21. A. Lerman, and A.M. Zeiher Endothelial function: cardiac events Circulation 111 2005 363 368 (Pubitemid 40165345)
22. V. Ambros The functions of animal microRNAs Nature 431 2004 350 355 (Pubitemid 39265675)
23. D.P. Bartel MicroRNAs: target recognition and regulatory functions Cell 136 2009 215 233
24. V. Ambros MicroRNA pathways in flies and worms: growth, death, fat, stress, and timing Cell 113 2003 673 676 (Pubitemid 36724931)
25. W. Filipowicz, S.N. Bhattacharyya, and N. Sonenberg Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight? Nature Reviews Genetics 9 2008 102 114
26. D. Betel, M. Wilson, A. Gabow, D.S. Marks, and C. Sander The microRNA.Org resource: targets and expression Nucleic Acids Research 36 2008 D149 D153
27. S. Griffiths-Jones, H.K. Saini, S. van Dongen, and A.J. Enright Mirbase: tools for microRNA genomics Nucleic Acids Research 36 2008 D154 D158
28. A. Kozomara, and S. Griffiths-Jones Mirbase: integrating microRNA annotation and deep-sequencing data Nucleic Acids Research 39 2011 D152 D157
29. X. Cai, C.H. Hagedorn, and B.R. Cullen Human microRNAs are processed from capped, polyadenylated transcripts that can also function as mRNAs RNA 10 2004 1957 1966 (Pubitemid 39557833)
30. Y. Lee, M. Kim, J. Han, K.H. Yeom, S. Lee, and S.H. Baek MicroRNA genes are transcribed by RNA polymerase II The EMBO Journal 23 2004 4051 4060 (Pubitemid 39472426)
31. Y. Lee, C. Ahn, J. Han, H. Choi, J. Kim, and J. Yim The nuclear RNAse III drosha initiates microRNA processing Nature 425 2003 415 419 (Pubitemid 37187272)
32. A.M. Denli, B.B. Tops, R.H. Plasterk, R.F. Ketting, and G.J. Hannon Processing of primary microRNAs by the microprocessor complex Nature 432 2004 231 235 (Pubitemid 39545854)
33. J.G. Ruby, C.H. Jan, and D.P. Bartel Intronic microRNA precursors that bypass drosha processing Nature 448 2007 83 86 (Pubitemid 47037009)
34. E. Lund, S. Guttinger, A. Calado, J.E. Dahlberg, and U. Kutay Nuclear export of microRNA precursors Science 303 2004 95 98 (Pubitemid 38055779)
35. G. Hutvagner, J. McLachlan, A.E. Pasquinelli, E. Balint, T. Tuschl, and P.D. Zamore A cellular function for the RNA-interference enzyme dicer in the maturation of the let-7 small temporal RNA Science 293 2001 834 838 (Pubitemid 32743968)
36. B.R. Cullen Transcription and processing of human microRNA precursors Molecular Cell 16 2004 861 865 (Pubitemid 40018397)
37. K. Okamura, M.D. Phillips, D.M. Tyler, H. Duan, Y.T. Chou, and E.C. Lai The regulatory activity of microRNA* species has substantial influence on microRNA and 3′UTR evolution Nature Structural and Molecular Biology 15 2008 354 363 (Pubitemid 351483397)
38. L. Guo, and Z. Lu The fate of miRNA* strand through evolutionary analysis: implication for degradation as merely carrier strand or potential regulatory molecule? PloS ONE 5 2010 e11387
39. J.S. Yang, M.D. Phillips, D. Betel, P. Mu, A. Ventura, and A.C. Siepel Widespread regulatory activity of vertebrate microRNA* species RNA 17 2011 312 326
40. H. Zhou, X. Huang, H. Cui, X. Luo, Y. Tang, and S. Chen Mir-155 and its star-form partner mir-155* cooperatively regulate type I interferon production by human plasmacytoid dendritic cells Blood 116 2010 5885 5894
41. G. Hutvagner, and P.D. Zamore A microRNA in a multiple-turnover RNAi enzyme complex Science 297 2002 2056 2060
42. Z. Mourelatos, J. Dostie, S. Paushkin, A. Sharma, B. Charroux, and L. Abel Mirnps: a novel class of ribonucleoproteins containing numerous microRNAs Genes and Development 16 2002 720 728 (Pubitemid 34274041)
43. S. Saxena, Z.O. Jonsson, and A. Dutta Small RNAs with imperfect match to endogenous mRNA repress translation. Implications for off-target activity of small inhibitory RNA in mammalian cells The Journal of Biological Chemistry 278 2003 44312 44319 (Pubitemid 37377177)
44. M.A. Valencia-Sanchez, J. Liu, G.J. Hannon, and R. Parker Control of translation and mRNA degradation by miRNAs and siRNAs Genes and Development 20 2006 515 524 (Pubitemid 43345317)
45. E.C. Lai Micro RNAs are complementary to 3′ UTR sequence motifs that mediate negative post-transcriptional regulation Nature Genetics 30 2002 363 364
46. R.C. Friedman, K.K.-H. Farh, C.B. Burge, and D.P. Bartel Most mammalian mRNAs are conserved targets of microRNAs Genome Research 2009 92 105
47. E. Hornstein, and N. Shomron Canalization of development by microRNAs Nature Genetics 38 Suppl. 2006 S20 S24
48. M.S. Ebert, and P.A. Sharp Roles for microRNAs in conferring robustness to biological processes Cell 2012 515 524
49. J. Krutzfeldt, and M. Stoffel MicroRNAs: a new class of regulatory genes affecting metabolism Cell Metabolism 4 2006 9 12 (Pubitemid 43942256)
50. C.Z. Chen, L. Li, H.F. Lodish, and D.P. Bartel MicroRNAs modulate hematopoietic lineage differentiation Science 303 2004 83 86 (Pubitemid 38055775)
51. W.J. Yang, D.D. Yang, S. Na, G.E. Sandusky, Q. Zhang, and G. Zhao Dicer is required for embryonic angiogenesis during mouse development The Journal of Biological Chemistry 280 2005 9330 9335 (Pubitemid 40409626)
52. E. Wienholds, W.P. Kloosterman, E. Miska, E. Alvarez-Saavedra, E. Berezikov, and E. de Bruijn MicroRNA expression in zebrafish embryonic development Science 309 2005 310 311 (Pubitemid 40967869)
53. M.N. Poy, L. Eliasson, J. Krutzfeldt, S. Kuwajima, X. Ma, and P.E. Macdonald A pancreatic islet-specific microRNA regulates insulin secretion Nature 432 2004 226 230 (Pubitemid 39545853)
54. A.M. Krichevsky, K.C. Sonntag, O. Isacson, and K.S. Kosik Specific microRNAs modulate embryonic stem cell-derived neurogenesis Stem Cells 24 2006 857 864 (Pubitemid 44464719)
55. H.B. Houbaviy, M.F. Murray, and P.A. Sharp Embryonic stem cell-specific microRNAs Developmental Cell 5 2003 351 358 (Pubitemid 37006477)
56. A.J. Giraldez, R.M. Cinalli, M.E. Glasner, A.J. Enright, J.M. Thomson, and S. Baskerville MicroRNAs regulate brain morphogenesis in zebrafish Science 308 2005 833 838 (Pubitemid 40629259)
57. E. Bernstein, S.Y. Kim, M.A. Carmell, E.P. Murchison, H. Alcorn, and M.Z. Li Dicer is essential for mouse development Nature Genetics 35 2003 215 217 (Pubitemid 37363172)
58. Y.S. Lee, K. Nakahara, J.W. Pham, K. Kim, Z. He, and E.J. Sontheimer Distinct roles for drosophila dicer-1 and dicer-2 in the siRNA/miRNA silencing pathways Cell 117 2004 69 81 (Pubitemid 38469899)
59. J. Liu, M.A. Carmell, F.V. Rivas, C.G. Marsden, J.M. Thomson, and J.J. Song Argonaute2 is the catalytic engine of mammalian RNAi Science 305 2004 1437 1441 (Pubitemid 39167657)
60. J. Lu, J. Qian, F. Chen, X. Tang, C. Li, and W.V. Cardoso Differential expression of components of the microRNA machinery during mouse organogenesis Biochemical and Biophysical Research Communications 334 2005 319 323 (Pubitemid 40982372)
61. J.E. Fish, and D. Srivastava MicroRNAs: opening a new vein in angiogenesis research Science Signaling 2 2009 pe1
62. S. Wang, and E.N. Olson Angiomirs - key regulators of angiogenesis Current Opinion in Genetics and Development 19 2009 205 211
63. Y. Suarez, and W.C. Sessa MicroRNAs as novel regulators of angiogenesis Circulation Research 104 2009 442 454
64. S. Batkai, and T. Thum MicroRNAs in hypertension: mechanisms and therapeutic targets Current Hypertension Reports 14 2012 79 87
65. S. Dangwal, and T. Thum MicroRNAs in platelet biogenesis and function Thrombosis and Haemostasis 108 2012 599 604
66. A. Schober, T. Thum, and A. Zernecke MicroRNAs in vascular biology - metabolism and atherosclerosis Thrombosis and Haemostasis 107 2012 603 604
67. T. Thum, and M. Mayr Review focus on the role of microRNA in cardiovascular biology and disease Cardiovascular Research 93 2012 543 544
68. P. Carmeliet Angiogenesis in health and disease Nature Medicine 9 2003 653 660 (Pubitemid 36749213)
69. P. Carmeliet Angiogenesis in life, disease and medicine Nature 438 2005 932 936 (Pubitemid 43093958)
70. L. Coultas, K. Chawengsaksophak, and J. Rossant Endothelial cells and vegf in vascular development Nature 438 2005 937 945 (Pubitemid 43093959)
71. J. Folkman Angiogenesis Annual Review of Medicine 57 2006 1 18 (Pubitemid 43261975)
72. N. Ferrara Role of vascular endothelial growth factor in regulation of physiological angiogenesis American Journal of Physiology. Cell Physiology 280 2001 C1358 C1366
73. C.W. Pugh, and P.J. Ratcliffe Regulation of angiogenesis by hypoxia: role of the HIF system Nature Medicine 9 2003 677 684 (Pubitemid 36749216)
74. P. Romagnani, L. Lasagni, F. Annunziato, M. Serio, and S. Romagnani Cxc chemokines: the regulatory link between inflammation and angiogenesis Trends in Immunology 25 2004 201 209 (Pubitemid 38372168)
75. G.D. Yancopoulos, S. Davis, N.W. Gale, J.S. Rudge, S.J. Wiegand, and J. Holash Vascular-specific growth factors and blood vessel formation Nature 407 2000 242 248
76. J. Folkman What is the role of endothelial cells in angiogenesis? Laboratory Investigation: A Journal of Technical Methods and Pathology 51 1984 601 604 (Pubitemid 15182526)
77. Y. Suarez, C. Fernandez-Hernando, J.S. Pober, and W.C. Sessa Dicer dependent microRNAs regulate gene expression and functions in human endothelial cells Circulation Research 100 2007 1164 1173 (Pubitemid 46684129)
78. A. Kuehbacher, C. Urbich, A.M. Zeiher, and S. Dimmeler Role of dicer and drosha for endothelial microRNA expression and angiogenesis Circulation Research 101 2007 59 68 (Pubitemid 47094624)
79. Y. Suarez, C. Fernandez-Hernando, J. Yu, S.A. Gerber, K.D. Harrison, and J.S. Pober Dicer-dependent endothelial microRNAs are necessary for postnatal angiogenesis Proceedings of the National Academy of Sciences of the United States of America 105 2008 14082 14087
80. L. Poliseno, A. Tuccoli, L. Mariani, M. Evangelista, L. Citti, and K. Woods MicroRNAs modulate the angiogenic properties of huvecs Blood 108 2006 3068 3071
81. T.A. Harris, M. Yamakuchi, M. Ferlito, J.T. Mendell, and C.J. Lowenstein MicroRNA-126 regulates endothelial expression of vascular cell adhesion molecule 1 Proceedings of the National Academy of Sciences of the United States of America 105 2008 1516 1521 (Pubitemid 351346546)
82. T.A. Harris, M. Yamakuchi, M. Kondo, P. Oettgen, and C.J. Lowenstein Ets-1 and ets-2 regulate the expression of microRNA-126 in endothelial cells Arteriosclerosis, Thrombosis, and Vascular Biology 30 2010 1990 1997
83. M. Lagos-Quintana, R. Rauhut, A. Yalcin, J. Meyer, W. Lendeckel, and T. Tuschl Identification of tissue-specific microRNAs from mouse Current Biology 12 2002 735 739 (Pubitemid 34455427)
84. P. Landgraf, M. Rusu, R. Sheridan, A. Sewer, N. Iovino, and A. Aravin A mammalian microRNA expression atlas based on small RNA library sequencing Cell 129 2007 1401 1414 (Pubitemid 46970709)
85. M.J. Fitch, L. Campagnolo, F. Kuhnert, and H. Stuhlmann Egfl7, a novel epidermal growth factor-domain gene expressed in endothelial cells Developmental Dynamics: An Official Publication of the American Association of Anatomists 230 2004 316 324 (Pubitemid 38669592)
86. L.H. Parker, M. Schmidt, S.W. Jin, A.M. Gray, D. Beis, and T. Pham The endothelial-cell-derived secreted factor egfl7 regulates vascular tube formation Nature 428 2004 754 758 (Pubitemid 38514720)
87. S. Wang, A.B. Aurora, B.A. Johnson, X. Qi, J. McAnally, and J.A. Hill The endothelial-specific microRNA mir-126 governs vascular integrity and angiogenesis Developmental Cell 15 2008 261 271
88. F. Kuhnert, M.R. Mancuso, J. Hampton, K. Stankunas, T. Asano, and C.Z. Chen Attribution of vascular phenotypes of the murine egfl7 locus to the microRNA mir-126 Development 135 2008 3989 3993
89. J.E. Fish, M.M. Santoro, S.U. Morton, S. Yu, R.F. Yeh, and J.D. Wythe Mir-126 regulates angiogenic signaling and vascular integrity Developmental Cell 15 2008 272 284
90. R. Sessa, G. Seano, L. di Blasio, P.A. Gagliardi, C. Isella, and E. Medico The mir-126 regulates angiopoietin-1 signaling and vessel maturation by targeting p85beta Biochimica et Biophysica Acta 1823 2012 1925 1935
91. S. Nicoli, C. Standley, P. Walker, A. Hurlstone, K.E. Fogarty, and N.D. Lawson MicroRNA-mediated integration of haemodynamics and vegf signalling during angiogenesis Nature 464 2010 1196 1200
92. C. van Solingen, L. Seghers, R. Bijkerk, J.M. Duijs, M.K. Roeten, and A.M. van Oeveren-Rietdijk Antagomir-mediated silencing of endothelial cell specific microRNA-126 impairs ischemia-induced angiogenesis Journal of Cellular and Molecular Medicine 13 2009 1577 1585
93. Y. Saito, J.M. Friedman, Y. Chihara, G. Egger, J.C. Chuang, and G. Liang Epigenetic therapy upregulates the tumor suppressor microRNA-126 and its host gene egfl7 in human cancer cells Biochemical and Biophysical Research Communications 379 2009 726 731
94. N. Yanaihara, N. Caplen, E. Bowman, M. Seike, K. Kumamoto, and M. Yi Unique microRNA molecular profiles in lung cancer diagnosis and prognosis Cancer Cell 9 2006 189 198 (Pubitemid 43357945)
95. S.F. Tavazoie, C. Alarcon, T. Oskarsson, D. Padua, Q. Wang, and P.D. Bos Endogenous human microRNAs that suppress breast cancer metastasis Nature 451 2008 147 152
96. E. Miko, Z. Margitai, Z. Czimmerer, I. Varkonyi, B. Dezso, and A. Lanyi Mir-126 inhibits proliferation of small cell lung cancer cells by targeting slc7a5 FEBS Letters 585 2011 1191 1196
97. S. Hamada, K. Satoh, W. Fujibuchi, M. Hirota, A. Kanno, and J. Unno Mir-126 acts as a tumor suppressor in pancreatic cancer cells via the regulation of adam9 Molecular Cancer Research 10 2012 3 10
98. B. Liu, X.C. Peng, X.L. Zheng, J. Wang, and Y.W. Qin Mir-126 restoration down-regulate vegf and inhibit the growth of lung cancer cell lines in vitro and in vivo Lung Cancer 66 2009 169 175
99. J.E. Fish, J.D. Wythe, T. Xiao, B.G. Bruneau, D.Y. Stainier, and D. Srivastava A slit/mir-218/robo regulatory loop is required during heart tube formation in zebrafish Development 138 2011 1409 1419
100. J. Tie, Y. Pan, L. Zhao, K. Wu, J. Liu, and S. Sun Mir-218 inhibits invasion and metastasis of gastric cancer by targeting the robo1 receptor PLoS Genetics 6 2010 e1000879
101. E.M. Small, L.B. Sutherland, K.N. Rajagopalan, S. Wang, and E.N. Olson MicroRNA-218 regulates vascular patterning by modulation of slit-robo signaling Circulation Research 107 2010 1336 1344
102. L. He, J.M. Thomson, M.T. Hemann, E. Hernando-Monge, D. Mu, and S. Goodson A microRNA polycistron as a potential human oncogene Nature 435 2005 828 833 (Pubitemid 40839734)
103. Y. Hayashita, H. Osada, Y. Tatematsu, H. Yamada, K. Yanagisawa, and S. Tomida A polycistronic microRNA cluster, mir-17-92, is overexpressed in human lung cancers and enhances cell proliferation Cancer Research 65 2005 9628 9632 (Pubitemid 41541436)
104. A. Ota, H. Tagawa, S. Karnan, S. Tsuzuki, A. Karpas, and S. Kira Identification and characterization of a novel gene, c13orf25, as a target for 13q31-q32 amplification in malignant lymphoma Cancer Research 64 2004 3087 3095 (Pubitemid 38581408)
105. K.A. O'Donnell, E.A. Wentzel, K.I. Zeller, C.V. Dang, and J.T. Mendell C-myc-regulated microRNAs modulate e2f1 expression Nature 435 2005 839 843 (Pubitemid 40839736)
106. L. Fontana, M.E. Fiori, S. Albini, L. Cifaldi, S. Giovinazzi, and M. Forloni Antagomir-17-5p abolishes the growth of therapy-resistant neuroblastoma through p21 and bim PloS ONE 3 2008 e2236
107. M. Dews, A. Homayouni, D. Yu, D. Murphy, C. Sevignani, and E. Wentzel Augmentation of tumor angiogenesis by a myc-activated microRNA cluster Nature Genetics 38 2006 1060 1065 (Pubitemid 44325933)
108. M. Otsuka, M. Zheng, M. Hayashi, J.D. Lee, O. Yoshino, and S. Lin Impaired microRNA processing causes corpus luteum insufficiency and infertility in mice The Journal of Clinical Investigation 118 2008 1944 1954 (Pubitemid 351632396)
109. C. Doebele, A. Bonauer, A. Fischer, A. Scholz, Y. Reiss, and C. Urbich Members of the microRNA-17-92 cluster exhibit a cell-intrinsic antiangiogenic function in endothelial cells Blood 115 2010 4944 4950
110. X. Qin, X. Wang, Y. Wang, Z. Tang, Q. Cui, and J. Xi MicroRNA-19a mediates the suppressive effect of laminar flow on cyclin d1 expression in human umbilical vein endothelial cells Proceedings of the National Academy of Sciences of the United States of America 107 2010 3240 3244
111. A. Bonauer, G. Carmona, M. Iwasaki, M. Mione, M. Koyanagi, and A. Fischer MicroRNA-92a controls angiogenesis and functional recovery of ischemic tissues in mice Science 324 2009 1710 1713
112. J. Semo, R. Sharir, A. Afek, C. Avivi, I. Barshack, and S. Maysel-Auslender The 106b-25 microRNA cluster is essential for neovascularization after hindlimb ischaemia in mice European Heart Journal 2013 Feb 17, [Epub ahead of print]
113. R. Chhabra, R. Dubey, and N. Saini Cooperative and individualistic functions of the microRNAs in the mir-23a-27a-24-2 cluster and its implication in human diseases Molecular Cancer 9 2010 232
114. Q. Zhou, R. Gallagher, R. Ufret-Vincenty, X. Li, E.N. Olson, and S. Wang Regulation of angiogenesis and choroidal neovascularization by members of microRNA-23-27-24 clusters Proceedings of the National Academy of Sciences of the United States of America 108 2011 8287 8292
115. J. Fiedler, V. Jazbutyte, B.C. Kirchmaier, S.K. Gupta, J. Lorenzen, and D. Hartmann MicroRNA-24 regulates vascularity after myocardial infarction Circulation 124 2011 720 730
116. C. Bang, J. Fiedler, and T. Thum Cardiovascular importance of the MicroRNA-23/27/24 family Microcirculation 19 2012 208 214
117. C. Urbich, D. Kaluza, T. Fromel, A. Knau, K. Bennewitz, and R.A. Boon MicroRNA-27a/b controls endothelial cell repulsion and angiogenesis by targeting semaphorin 6a Blood 119 2012 1607 1616
118. K.C. Wang, L.X. Garmire, A. Young, P. Nguyen, A. Trinh, and S. Subramaniam Role of microRNA-23b in flow-regulation of rb phosphorylation and endothelial cell growth Proceedings of the National Academy of Sciences of the United States of America 107 2010 3234 3239
119. M.L. Iruela-Arispe, and H.F. Dvorak Angiogenesis: a dynamic balance of stimulators and inhibitors Thrombosis and Haemostasis 78 1997 672 677 (Pubitemid 27289325)
120. M.J. Cross, and L. Claesson-Welsh Fgf and vegf function in angiogenesis: signalling pathways, biological responses and therapeutic inhibition Trends in Pharmacological Sciences 22 2001 201 207 (Pubitemid 32244307)
121. D.W. Leung, G. Cachianes, W.J. Kuang, D.V. Goeddel, and N. Ferrara Vascular endothelial growth factor is a secreted angiogenic mitogen Science 246 1989 1306 1309 (Pubitemid 20066716)
122. A.K. Olsson, A. Dimberg, J. Kreuger, and L. Claesson-Welsh Vegf receptor signalling - in control of vascular function Nature Reviews Molecular Cell Biology 7 2006 359 371
123. M. Presta, P. Dell'Era, S. Mitola, E. Moroni, R. Ronca, and M. Rusnati Fibroblast growth factor/fibroblast growth factor receptor system in angiogenesis Cytokine and Growth Factor Reviews 16 2005 159 178 (Pubitemid 40616114)
124. A. Chamorro-Jorganes, E. Araldi, L.O. Penalva, D. Sandhu, C. Fernandez-Hernando, and Y. Suarez MicroRNA-16 and microRNA-424 regulate cell-autonomous angiogenic functions in endothelial cells via targeting vascular endothelial growth factor receptor-2 and fibroblast growth factor receptor-1 Arteriosclerosis, Thrombosis, and Vascular Biology 31 2011 2595 2606
125. A.S. Nudelman, D.P. DiRocco, T.J. Lambert, M.G. Garelick, J. Le, and N.M. Nathanson Neuronal activity rapidly induces transcription of the creb-regulated microRNA-132, in vivo Hippocampus 20 2010 492 498
126. N. Vo, M.E. Klein, O. Varlamova, D.M. Keller, T. Yamamoto, and R.H. Goodman A camp-response element binding protein-induced microRNA regulates neuronal morphogenesis Proceedings of the National Academy of Sciences of the United States of America 102 2005 16426 16431 (Pubitemid 41688930)
127. S. Anand, B.K. Majeti, L.M. Acevedo, E.A. Murphy, R. Mukthavaram, and L. Scheppke MicroRNA-132-mediated loss of p120rasgap activates the endothelium to facilitate pathological angiogenesis Nature Medicine 16 2010 909 914
128. P. Dentelli, L. Del Sorbo, A. Rosso, A. Molinar, G. Garbarino, and G. Camussi Human il-3 stimulates endothelial cell motility and promotes in vivo new vessel formation Journal of Immunology 163 1999 2151 2159 (Pubitemid 29382222)
129. E. Brogi, J.A. Winkles, R. Underwood, S.K. Clinton, G.F. Alberts, and P. Libby Distinct patterns of expression of fibroblast growth factors and their receptors in human atheroma and nonatherosclerotic arteries. Association of acidic fgf with plaque microvessels and macrophages The Journal of Clinical Investigation 92 1993 2408 2418 (Pubitemid 23333549)
130. P. Dentelli, A. Rosso, F. Orso, C. Olgasi, D. Taverna, and M.F. Brizzi MicroRNA-222 controls neovascularization by regulating signal transducer and activator of transcription 5a expression Arteriosclerosis, Thrombosis, and Vascular Biology 30 2010 1562 1568
131. Y. Chen, M. Banda, C.L. Speyer, J.S. Smith, A.B. Rabson, and D.H. Gorski Regulation of the expression and activity of the antiangiogenic homeobox gene gax/meox2 by zeb2 and microRNA-221 Molecular and Cellular Biology 30 2010 3902 3913
132. N. Zhu, D. Zhang, S. Chen, X. Liu, L. Lin, and X. Huang Endothelial enriched microRNAs regulate angiotensin ii-induced endothelial inflammation and migration Atherosclerosis 215 2011 286 293
133. P. Carmeliet, and R.K. Jain Molecular mechanisms and clinical applications of angiogenesis Nature 473 2011 298 307
134. C. Camps, F.M. Buffa, S. Colella, J. Moore, C. Sotiriou, and H. Sheldon Hsa-mir-210 is induced by hypoxia and is an independent prognostic factor in breast cancer Clinical Cancer Research: An Official Journal of the American Association for Cancer Research 14 2008 1340 1348 (Pubitemid 351413913)
135. P. Fasanaro, Y. D'Alessandra, V. Di Stefano, R. Melchionna, S. Romani, and G. Pompilio MicroRNA-210 modulates endothelial cell response to hypoxia and inhibits the receptor tyrosine kinase ligand ephrin-a3 The Journal of Biological Chemistry 283 2008 15878 15883
136. S. Hu, M. Huang, Z. Li, F. Jia, Z. Ghosh, and M.A. Lijkwan MicroRNA-210 as a novel therapy for treatment of ischemic heart disease Circulation 122 2010 S124 S131
137. E. Raitoharju, L.P. Lyytikainen, M. Levula, N. Oksala, A. Mennander, and M. Tarkka Mir-21, mir-210, mir-34a, and mir-146a/b are up-regulated in human atherosclerotic plaques in the tampere vascular study Atherosclerosis 219 2011 211 217
138. G. Spinetti, O. Fortunato, A. Caporali, S. Shantikumar, M. Marchetti, and M. Meloni MicroRNA-15a and microRNA-16 impair human circulating pro-angiogenic cell (pac) functions and are increased in the pacs and serum of patients with critical limb ischemia Circulation Research 112 2013 335 346
139. T.G. Hullinger, R.L. Montgomery, A.G. Seto, B.A. Dickinson, H.M. Semus, and J.M. Lynch Inhibition of mir-15 protects against cardiac ischemic injury Circulation Research 110 2012 71 81
140. K.J. Yin, Z. Deng, M. Hamblin, Y. Xiang, H. Huang, and J. Zhang Peroxisome proliferator-activated receptor delta regulation of mir-15a in ischemia-induced cerebral vascular endothelial injury The Journal of Neuroscience: The Official Journal of the Society for Neuroscience 30 2010 6398 6408
141. A. Caporali, M. Meloni, C. Vollenkle, D. Bonci, G.B. Sala-Newby, and R. Addis Deregulation of microRNA-503 contributes to diabetes mellitus-induced impairment of endothelial function and reparative angiogenesis after limb ischemia Circulation 123 2011 282 291
142. G. Ghosh, I.V. Subramanian, N. Adhikari, X. Zhang, H.P. Joshi, and D. Basi Hypoxia-induced microRNA-424 expression in human endothelial cells regulates HIF-alpha isoforms and promotes angiogenesis The Journal of Clinical Investigation 120 2010 4141 4154
143. J.M. Isner, and T. Asahara Angiogenesis and vasculogenesis as therapeutic strategies for postnatal neovascularization The Journal of Clinical Investigation 103 1999 1231 1236 (Pubitemid 29218292)
144. Y. Minami, M. Satoh, C. Maesawa, Y. Takahashi, T. Tabuchi, and T. Itoh Effect of atorvastatin on microRNA 221/222 expression in endothelial progenitor cells obtained from patients with coronary artery disease European Journal of Clinical Investigation 39 2009 359 367
145. C. Sabatel, L. Malvaux, N. Bovy, C. Deroanne, V. Lambert, and M.L. Gonzalez MicroRNA-21 exhibits antiangiogenic function by targeting rhob expression in endothelial cells PloS ONE 6 2011 e16979
146. S. Zhu, S. Deng, Q. Ma, T. Zhang, C. Jia, and D. Zhuo MicroRNA-10a* and microRNA-21 modulate endothelial progenitor cell senescence via suppressing high-mobility group a2 Circulation Research 112 2013 152 164
147. F. Fleissner, V. Jazbutyte, J. Fiedler, S.K. Gupta, X. Yin, and Q. Xu Short communication: asymmetric dimethylarginine impairs angiogenic progenitor cell function in patients with coronary artery disease through a microRNA-21-dependent mechanism Circulation Research 107 2010 138 143
148. J. Guduric-Fuchs, A. O'Connor, A. Cullen, L. Harwood, R.J. Medina, and C.L. O'Neill Deep sequencing reveals predominant expression of mir-21 amongst the small non-coding RNAs in retinal microvascular endothelial cells Journal of Cellular Biochemistry 113 2012 2098 2111
149. A.B. Gaur, S.L. Holbeck, N.H. Colburn, and M.A. Israel Downregulation of pdcd4 by mir-21 facilitates glioblastoma proliferation in vivo Neuro-oncology 13 2011 580 590
150. J. Tao, Q. Lu, D. Wu, P. Li, B. Xu, and W. Qing MicroRNA-21 modulates cell proliferation and sensitivity to doxorubicin in bladder cancer cells Oncology Reports 25 2011 1721 1729
151. R. Menghini, V. Casagrande, M. Cardellini, E. Martelli, A. Terrinoni, and F. Amati MicroRNA 217 modulates endothelial cell senescence via silent information regulator 1 Circulation 120 2009 1524 1532
152. M. Vasa-Nicotera, H. Chen, P. Tucci, A.L. Yang, G. Saintigny, and R. Menghini Mir-146a is modulated in human endothelial cell with aging Atherosclerosis 217 2011 326 330
153. T.A. Springer Traffic signals on endothelium for lymphocyte recirculation and leukocyte emigration Annual Review of Physiology 57 1995 827 872
154. E.C. Butcher Leukocyte-endothelial cell recognition: three (or more) steps to specificity and diversity Cell 67 1991 1033 1036 (Pubitemid 121001517)
155. R. Bonfanti, B.C. Furie, B. Furie, and D.D. Wagner Padgem (gmp140) is a component of Weibel-Palade bodies of human endothelial cells Blood 73 1989 1109 1112 (Pubitemid 19107409)
156. J. Middleton, S. Neil, J. Wintle, I. Clark-Lewis, H. Moore, and C. Lam Transcytosis and surface presentation of il-8 by venular endothelial cells Cell 91 1997 385 395 (Pubitemid 27467969)
157. M.P. Bevilacqua, R.M. Nelson, G. Mannori, and O. Cecconi Endothelial-leukocyte adhesion molecules in human disease Annual Review of Medicine 45 1994 361 378 (Pubitemid 24158168)
158. J.S. Pober Endothelial activation: intracellular signaling pathways Arthritis Research 4 Suppl. 3 2002 S109 S116
159. E. Sonkoly, and A. Pivarcsi Advances in microRNAs: implications for immunity and inflammatory diseases Journal of Cellular and Molecular Medicine 13 2009 24 38
160. R.M. O'Connell, K.D. Taganov, M.P. Boldin, G. Cheng, and D. Baltimore MicroRNA-155 is induced during the macrophage inflammatory response Proceedings of the National Academy of Sciences of the United States of America 104 2007 1604 1609 (Pubitemid 46214637)
161. M.M. Perry, S.A. Moschos, A.E. Williams, N.J. Shepherd, H.M. Larner-Svensson, and M.A. Lindsay Rapid changes in microRNA-146a expression negatively regulate the il-1beta-induced inflammatory response in human lung alveolar epithelial cells Journal of Immunology 180 2008 5689 5698
162. K.D. Taganov, M.P. Boldin, K.J. Chang, and D. Baltimore Nf-kappab-dependent induction of microRNA mir-146, an inhibitor targeted to signaling proteins of innate immune responses Proceedings of the National Academy of Sciences of the United States of America 103 2006 12481 12486 (Pubitemid 44267285)
163. E. Tili, J.J. Michaille, A. Cimino, S. Costinean, C.D. Dumitru, and B. Adair Modulation of mir-155 and mir-125b levels following lipopolysaccharide/ tnf-alpha stimulation and their possible roles in regulating the response to endotoxin shock Journal of Immunology 179 2007 5082 5089
164. F. Bazzoni, M. Rossato, M. Fabbri, D. Gaudiosi, M. Mirolo, and L. Mori Induction and regulatory function of mir-9 in human monocytes and neutrophils exposed to proinflammatory signals Proceedings of the National Academy of Sciences of the United States of America 106 2009 5282 5287
165. Y. Suarez, C. Wang, T.D. Manes, and J.S. Pober Cutting edge: Tnf-induced microRNAs regulate tnf-induced expression of e-selectin and intercellular adhesion molecule-1 on human endothelial cells: feedback control of inflammation Journal of Immunology 184 2010 21 25
166. X. Sun, B. Icli, A.K. Wara, N. Belkin, S. He, and L. Kobzik MicroRNA-181b regulates nf-kappab-mediated vascular inflammation The Journal of Clinical Investigation 122 2012 1973 1990
167. Y. Fang, C. Shi, E. Manduchi, M. Civelek, and P.F. Davies MicroRNA-10a regulation of proinflammatory phenotype in athero-susceptible endothelium in vivo and in vitro Proceedings of the National Academy of Sciences of the United States of America 107 2010 13450 13455
168. D. Li, and J.L. Mehta Antisense to lox-1 inhibits oxidized ldl-mediated upregulation of monocyte chemoattractant protein-1 and monocyte adhesion to human coronary artery endothelial cells Circulation 101 2000 2889 2895 (Pubitemid 30415877)
169. D. Li, P. Yang, Q. Xiong, X. Song, X. Yang, and L. Liu MicroRNA-125a/b-5p inhibits endothelin-1 expression in vascular endothelial cells Journal of Hypertension 28 2010 1646 1654
170. B. Qin, B. Xiao, D. Liang, J. Xia, Y. Li, and H. Yang MicroRNAs expression in ox-ldl treated huvecs: Mir-365 modulates apoptosis and bcl-2 expression Biochemical and Biophysical Research Communications 410 2011 127 133
171. L. Hajra, A.I. Evans, M. Chen, S.J. Hyduk, T. Collins, and M.I. Cybulsky The nf-kappa b signal transduction pathway in aortic endothelial cells is primed for activation in regions predisposed to atherosclerotic lesion formation Proceedings of the National Academy of Sciences of the United States of America 97 2000 9052 9057 (Pubitemid 30626672)
172. Y. Fang, and P.F. Davies Site-specific microRNA-92a regulation of kruppel-like factors 4 and 2 in atherosusceptible endothelium Arteriosclerosis, Thrombosis, and Vascular Biology 32 2012 979 987
173. S.M. McCormick, S.G. Eskin, L.V. McIntire, C.L. Teng, C.M. Lu, and C.G. Russell DNA microarray reveals changes in gene expression of shear stressed human umbilical vein endothelial cells Proceedings of the National Academy of Sciences of the United States of America 98 2001 8955 8960 (Pubitemid 32743851)
174. R.J. Dekker, S. van Soest, R.D. Fontijn, S. Salamanca, P.G. de Groot, and E. VanBavel Prolonged fluid shear stress induces a distinct set of endothelial cell genes, most specifically lung kruppel-like factor (klf2) Blood 100 2002 1689 1698 (Pubitemid 34925146)
175. G.P. Sorescu, M. Sykes, D. Weiss, M.O. Platt, A. Saha, and J. Hwang Bone morphogenic protein 4 produced in endothelial cells by oscillatory shear stress stimulates an inflammatory response The Journal of Biological Chemistry 278 2003 31128 31135 (Pubitemid 36994628)
176. C.W. Ni, H. Qiu, and H. Jo MicroRNA-663 upregulated by oscillatory shear stress plays a role in inflammatory response of endothelial cells American Journal of Physiology Heart and Circulatory Physiology 300 2011 H1762 H1769
177. E. Dejana, and A. Del Maschio Molecular organization and functional regulation of cell to cell junctions in the endothelium Thrombosis and Haemostasis 74 1995 309 312
178. H.J. Schnittler Structural and functional aspects of intercellular junctions in vascular endothelium Basic Research in Cardiology 93 Suppl. 3 1998 30 39
179. A.L. Baldwin, and G. Thurston Mechanics of endothelial cell architecture and vascular permeability Critical Reviews in Biomedical Engineering 29 2001 247 278 (Pubitemid 32549967)
180. J.S. Alexander, and J.W. Elrod Extracellular matrix, junctional integrity and matrix metalloproteinase interactions in endothelial permeability regulation Journal of Anatomy 200 2002 561 574 (Pubitemid 34823048)
181. E. Dejana, M. Corada, and M.G. Lampugnani Endothelial cell-to-cell junctions FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology 9 1995 910 918
182. T. Pepini, E.E. Gorbunova, I.N. Gavrilovskaya, J.E. Mackow, and E.R. Mackow Andes virus regulation of cellular microRNAs contributes to hantavirus-induced endothelial cell permeability Journal of Virology 84 2010 11929 11936
183. M.S. Nicoloso, R. Spizzo, M. Shimizu, S. Rossi, and G.A. Calin MicroRNAs - the micro steering wheel of tumour metastases Nature Reviews Cancer 9 2009 293 302
184. L.M. Acevedo, S.M. Weis, and D.A. Cheresh Robo4 counteracts vegf signaling Nature Medicine 14 2008 372 373 (Pubitemid 351499382)
185. C.A. Jones, N.R. London, H. Chen, K.W. Park, D. Sauvaget, and R.A. Stockton Robo4 stabilizes the vascular network by inhibiting pathologic angiogenesis and endothelial hyperpermeability Nature Medicine 14 2008 448 453 (Pubitemid 351499393)
186. W.C. Sessa Enos at a glance Journal of Cell Science 117 2004 2427 2429 (Pubitemid 38877838)
187. J.S. Stamler, D.J. Singel, and J. Loscalzo Biochemistry of nitric oxide and its redox-activated forms Science 258 1992 1898 1902 (Pubitemid 23026727)
188. R. Govers, and T.J. Rabelink Cellular regulation of endothelial nitric oxide synthase American Journal of Physiology. Renal Physiology 280 2001 F193 F206
189. D. Fulton, J.P. Gratton, T.J. McCabe, J. Fontana, Y. Fujio, and K. Walsh Regulation of endothelium-derived nitric oxide production by the protein kinase akt Nature 399 1999 597 601
190. H.X. Sun, D.Y. Zeng, R.T. Li, R.P. Pang, H. Yang, and Y.L. Hu Essential role of microRNA-155 in regulating endothelium-dependent vasorelaxation by targeting endothelial nitric oxide synthase Hypertension 60 2012 1407 1414
191. M.E. Mendelsohn, S. O'Neill, D. George, and J. Loscalzo Inhibition of fibrinogen binding to human platelets by s-nitroso-n-acetylcysteine The Journal of Biological Chemistry 265 1990 19028 19034
192. J.Y. Jeremy, D. Rowe, A.M. Emsley, and A.C. Newby Nitric oxide and the proliferation of vascular smooth muscle cells Cardiovascular Research 43 1999 580 594 (Pubitemid 29369257)
193. A.M. Lefer Nitric oxide: nature's naturally occurring leukocyte inhibitor Circulation 95 1997 553 554 (Pubitemid 27063023)
194. G.K. Hansson, and P. Libby The immune response in atherosclerosis: a double-edged sword Nature Reviews Immunology 6 2006 508 519 (Pubitemid 43980523)
195. M. Weber, M.B. Baker, J.P. Moore, and C.D. Searles Mir-21 is induced in endothelial cells by shear stress and modulates apoptosis and enos activity Biochemical and Biophysical Research Communications 393 2010 643 648
196. J. Zhou, K.C. Wang, W. Wu, S. Subramaniam, J.Y. Shyy, and J.J. Chiu MicroRNA-21 targets peroxisome proliferators-activated receptor-alpha in an autoregulatory loop to modulate flow-induced endothelial inflammation Proceedings of the National Academy of Sciences of the United States of America 108 2011 10355 10360
197. M. Yanagisawa, H. Kurihara, S. Kimura, Y. Tomobe, M. Kobayashi, and Y. Mitsui A novel potent vasoconstrictor peptide produced by vascular endothelial cells Nature 332 1988 411 415 (Pubitemid 18090241)
198. F. Bohm, and J. Pernow The importance of endothelin-1 for vascular dysfunction in cardiovascular disease Cardiovascular Research 76 2007 8 18 (Pubitemid 47362047)
199. X. Chen, H. Liang, J. Zhang, K. Zen, and C.-Y. Zhang Secreted microRNAs: a new form of intercellular communication Trends in Cell Biology 22 2012 125 132
200. M. Mittelbrunn, and F. Sánchez-Madrid Intercellular communication: diverse structures for exchange of genetic information Nature Reviews Molecular Cell Biology 2012 328 335
201. E. Araldi, E.-M. Krämer-Albers, E.N.-t Hoen, H. Peinado, K.M. Psonka-Antonczyk, and P. Rao International society for extracellular vesicles: first annual meeting, April 17-21, 2012: Isev-2012 Journal of Extracellular Vesicles 1 2012 19995
202. S. Mathivanan, H. Ji, and R.J. Simpson Exosomes: extracellular organelles important in intercellular communication Journal of Proteomics 2010 1907 1920
203. A. Montecalvo, A.T. Larregina, W.J. Shufesky, D.B. Stolz, M.L.G. Sullivan, and J.M. Karlsson Mechanism of transfer of functional microRNAs between mouse dendritic cells via exosomes Blood 2012 756 766
204. S. Rana, S. Yue, D. Stadel, and M. Zöller Toward tailored exosomes: the exosomal tetraspanin web contributes to target cell selection International Journal of Biochemistry and Cell Biology 2012 1574 1584
205. Y. Zhang, D. Liu, X. Chen, J. Li, L. Li, and Z. Bian Secreted monocytic mir-150 enhances targeted endothelial cell migration Molecular Cell 2010 133 144
206. M. Mineo, S.H. Garfield, S. Taverna, A. Flugy, G. De Leo, and R. Alessandro Exosomes released by k562 chronic myeloid leukemia cells promote angiogenesis in a src-dependent fashion Angiogenesis 2011 33 45
207. C. Grange, M. Tapparo, F. Collino, L. Vitillo, C. Damasco, and M.-C. Deregibus Microvesicles released from human renal cancer stem cells stimulate angiogenesis and formation of lung premetastatic niche Cancer Research 2011 5346 5356
208. G. Zhuang, X. Wu, Z. Jiang, I. Kasman, J. Yao, and Y. Guan Tumour-secreted mir-9 promotes endothelial cell migration and angiogenesis by activating the jak-stat pathway The EMBO Journal: Nature Publishing Group 2012 1 11
209. A. Zernecke, K. Bidzhekov, H. Noels, E. Shagdarsuren, L. Gan, and B. Denecke Delivery of microRNA-126 by apoptotic bodies induces cxcl12-dependent vascular protection Science Signaling 2009 pra81
210. V. Cantaluppi, S. Gatti, D. Medica, F. Figliolini, S. Bruno, and M.C. Deregibus Microvesicles derived from endothelial progenitor cells protect the kidney from ischemia-reperfusion injury by microRNA-dependent reprogramming of resident renal cells Kidney 2012 412 427
211. A. Ranghino, V. Cantaluppi, and C. Grange Endothelial progenitor cell-derived microvesicles improve neovascularization in a murine model of hindlimb ischemia International Journal of Immunopathology and Pharmacology 25 2012 75 85
212. E. Hergenreider, S. Heydt, K. Treguer, T. Boettger, A.J. Horrevoets, and A.M. Zeiher Atheroprotective communication between endothelial cells and smooth muscle cells through miRNAs Nature Cell Biology 14 2012 249 256
213. M.P. Hunter, N. Ismail, X. Zhang, B.D. Aguda, E.J. Lee, and L. Yu Detection of microRNA expression in human peripheral blood microvesicles PloS ONE: Public Library of Science 2008 pe3694
214. J. Skog, T. Wurdinger, S. van Rijn, D.H. Meijer, L. Gainche, and M. Sena-Esteves Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers Nature Cell Biology 10 2008 1470 1476
215. S. Fichtlscherer, S. De Rosa, H. Fox, T. Schwietz, A. Fischer, and C. Liebetrau Circulating microRNAs in patients with coronary artery disease Circulation Research 107 2010 677 684
216. A. Zampetaki, S. Kiechl, I. Drozdov, P. Willeit, U. Mayr, and M. Prokopi Plasma microRNA profiling reveals loss of endothelial mir-126 and other microRNAs in type 2 diabetes Circulation Research 107 2010 810 817
217. G. Hutvagner, M.J. Simard, C.C. Mello, and P.D. Zamore Sequence-specific inhibition of small RNA function PLoS Biology 2 2004 E98
218. E. van Rooij, W.S. Marshall, and E.N. Olson Toward microRNA-based therapeutics for heart disease: the sense in antisense Circulation Research 103 2008 919 928
219. A.G. Bader, D. Brown, and M. Winkler The promise of microRNA replacement therapy Cancer Research 70 2010 7027 7030
220. J. Krutzfeldt, N. Rajewsky, R. Braich, K.G. Rajeev, T. Tuschl, and M. Manoharan Silencing of microRNAs in vivo with 'antagomirs' Nature 438 2005 685 689
221. K.J. Rayner, C.C. Esau, F.N. Hussain, A.L. McDaniel, S.M. Marshall, and J.M. van Gils Inhibition of mir-33a/b in non-human primates raises plasma hdl and lowers vldl triglycerides Nature 478 2011 404 407
222. J. Elmen, M. Lindow, S. Schutz, M. Lawrence, A. Petri, and S. Obad Lna-mediated microRNA silencing in non-human primates Nature 452 2008 896 899 (Pubitemid 351550859)
223. J. Worm, J. Stenvang, A. Petri, K.S. Frederiksen, S. Obad, and J. Elmen Silencing of microRNA-155 in mice during acute inflammatory response leads to derepression of c/ebp beta and down-regulation of g-csf Nucleic Acids Research 37 2009 5784 5792
224. J. Elmen, M. Lindow, A. Silahtaroglu, M. Bak, M. Christensen, and A. Lind-Thomsen Antagonism of microRNA-122 in mice by systemically administered lna-antimir leads to up-regulation of a large set of predicted target mRNAs in the liver Nucleic Acids Research 36 2008 1153 1162 (Pubitemid 351330933)
225. C.L. Jopling, M. Yi, A.M. Lancaster, S.M. Lemon, and P. Sarnow Modulation of hepatitis c virus RNA abundance by a liver-specific microRNA Science 309 2005 1577 1581 (Pubitemid 41266486)
226. B. Gentner, G. Schira, A. Giustacchini, M. Amendola, B.D. Brown, and M. Ponzoni Stable knockdown of microRNA in vivo by lentiviral vectors Nature Methods 6 2009 63 66
227. M.S. Ebert, and P.A. Sharp MicroRNA sponges: progress and possibilities RNA 16 2010 2043 2050
228. F. Takeshita, L. Patrawala, M. Osaki, R.U. Takahashi, Y. Yamamoto, and N. Kosaka Systemic delivery of synthetic microRNA-16 inhibits the growth of metastatic prostate tumors via downregulation of multiple cell-cycle genes Molecular Therapy: The Journal of the American Society of Gene Therapy 18 2010 181 187