MicroRNA-15a and MicroRNA-16 impair human circulating proangiogenic cell functions and are increased in the proangiogenic cells and serum of patients with critical limb ischemia

Circulation Research

Volumn 112, Issue 2, 2013, Pages 335-346

  Spinetti, Gaia ^a,b   Fortunato, Orazio ^b   Caporali, Andrea ^a   Shantikumar, Saran ^a   Marchetti, Micol ^a   Meloni, Marco ^a   Descamps, Betty ^a   Floris, Ilaria ^a   Sangalli, Elena ^b   Vono, Rosa ^b   Faglia, Ezio ^c   Specchia, Claudia ^d   Pintus, Gianfranco ^e   Madeddu, Paolo ^a   Emanueli, Costanza ^a  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

^b Experimental Cardiovascular Medicine   (United Kingdom)

^c IRCCS   (Italy)

^d UNIVERSITY OF BRESCIA   (Italy)

^e UNIVERSITY OF SASSARI   (Italy)

Author keywords

angiogenesis; diabetes mellitus; ischemia; microRNA 15a; microRNA 16; microRNAs; proangiogenic cells

Indexed keywords

ARGONAUTE 2 PROTEIN; MICRORNA 15A; MICRORNA 16; PROTEIN KINASE B; RNA ANTIBODY; VASCULOTROPIN A;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERIOLE; ARTICLE; BLOOD FLOW; BLOOD LEVEL; CELL ENGINEERING; CELL FUNCTION; CELL LEVEL; CELL MIGRATION; CELL SURVIVAL; CELL TRANSPLANTATION; CIRCULATING PROANGIOGENIC CELL; CONJUGATION; CONTROLLED STUDY; CRITICAL LIMB ISCHEMIA; DIABETES MELLITUS; DIAGNOSTIC VALUE; ENDOTHELIAL PROGENITOR CELL; EX VIVO STUDY; EXOSOME; FOLLOW UP; GENE EXPRESSION PROFILING; GENE OVEREXPRESSION; GENE TARGETING; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IMMUNE DEFICIENCY; IMMUNOCOMPROMISED PATIENT; LEG AMPUTATION; LEG REVASCULARIZATION; LIMB AMPUTATION; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN TARGETING; RESTENOSIS; RNA ANALYSIS;

ANIMALS; CELL MOVEMENT; CELL SURVIVAL; CELL TRANSPLANTATION; CELLS, CULTURED; DIABETES COMPLICATIONS; DIABETES MELLITUS, TYPE 2; HEK293 CELLS; HINDLIMB; HUMANS; ISCHEMIA; MICE; MICE, NUDE; MICRORNAS; NEOVASCULARIZATION, PATHOLOGIC;

EID: 84872866537     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.111.300418     Document Type: Article

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