A pancreatic islet-specific microRNA regulates insulin secretion

Nature

Volumn 432, Issue 7014, 2004, Pages 226-230

  Poy, Matthew N ^a   Eliasson, Lena ^b   Krutzfeldt, Jan ^a   Kuwajima, Satoru ^a   Ma, Xiaosong ^b   MacDonald, Patrick E ^b   Pfeffer, Sébastien ^a   Tuschl, Thomas ^a   Rajewsky, Nikolaus ^c   Rorsman, Patrick ^b,d   Stoffel, Markus ^a  

^a ROCKEFELLER UNIVERSITY   (United States)

^b LUND UNIVERSITY   (Sweden)

^c NEW YORK UNIVERSITY   (United States)

^d UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BIODIVERSITY; CLONING; DISEASES; DRUG THERAPY; GENES; INSULIN;

EXOCYTOSIS; MICRORIBONUCLEIC ACIDS (MIRNA); NON-CODING RNAS; PANCREATIC ENDOCRINE CELLS;

RNA;

GLUCOSE; INSULIN; MICRORNA; PROTEIN INHIBITOR; RECOMBINANT SOMATOMEDIN C; SMALL INTERFERING RNA;

RNA;

ANIMAL CELL; ARTICLE; CALCIUM CELL LEVEL; CALCIUM SIGNALING; CONTROLLED STUDY; DIABETES MELLITUS; EXOCYTOSIS; GENE EXPRESSION REGULATION; GENE FUNCTION; GENE IDENTIFICATION; GENE OVEREXPRESSION; GENE TARGETING; GLUCOSE METABOLISM; INSULIN RELEASE; MOLECULAR CLONING; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PANCREAS ISLET; PANCREAS ISLET CELL; PRIORITY JOURNAL; PROTEIN TARGETING; REGULATORY MECHANISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA ANALYSIS; RNA SEQUENCE; SIGNAL TRANSDUCTION; TISSUE SPECIFICITY; TRANSLATION REGULATION;

ANIMALS; CALCIUM SIGNALING; CELL LINE; CLONING, MOLECULAR; DIABETES MELLITUS; EXOCYTOSIS; GENE EXPRESSION; GENE SILENCING; GENE THERAPY; GLUCOSE; INSULIN; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; ISLETS OF LANGERHANS; MICE; MICRORNAS; ORGAN SPECIFICITY; POTASSIUM CHLORIDE; SUBSTRATE SPECIFICITY; TOLBUTAMIDE;

ANIMALIA;

EID: 9144270691     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/nature03076     Document Type: Article

References (30)

1. Bartel, D. P. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 116, 281-297 (2004).
2. Lagos-Quintana, M., Rauhut, R., Lendeckel, W. & Tuschl, T. Identification of novel genes coding for small expressed RNAs. Science 294, 853-858 (2001).
3. Lau, N. C., Lim, L. P., Weinstein, E. G. & Bartel, D. P. An abundant class of tiny RNAs with probable regulatory roles in Caenorhabditis elegans. Science 294, 858-862 (2001).
4. Lee, R. C. & Ambros, V. An extensive class of small RNAs in Caenorhabditis elegans. Science 294, 862-864 (2001).
5. Carrington, J. C. & Ambros, V. Role of microRNAs in plant and animal development. Science 301, 336-338 (2003).
6. Wightman, B., Ha, I. & Ruvkun, G. Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans. Cell 75, 855-862 (1993).
7. Olsen, P. H. & Ambros, V. The lin-4 regulatory RNA controls developmental timing in Caenorhabditis elegans by blocking LIN-14 protein synthesis after the initiation of translation. Dev. Biol. 216, 671-680 (1999).
8. Brennecke, J., Hipfner, D. R., Stark, A., Russell, R. B. & Cohen, S. M. bantam encodes a develop men tally regulated microRNA that controls cell proliferation and regulates the proapoptotic gene hid in Drosophila. Cell 113, 25-36 (2003).
9. Xu, P., Vernooy, S. Y., Guo, M. & Hay, B. A. The Drosophila microRNA Mir-14 suppresses cell death and is required for normal fat metabolism. Curr. Biol. 13, 790-795 (2003).
10. Pfeffer, S., Lagos-Quintana, M. & Tuschl, T. in Current Protocols in Molecular Biology (eds Ausubel, F. M. B. R. et al.) Ch. 26.4.1-26.4.18 (Wiley Interscience, New York, 2003).
11. Ambros, V. et al. A uniform system for microRNA annotation. RNA 9, 277-279 (2003).
12. Meister, G., Landthaler, M., Dorsett, Y. & Tuschl, T. Sequence-specific inhibition of microRNA- and siRNA-induced RNA silencing. RNA 10, 544-550 (2004).
13. Hutvagner, G., Simard, M. J., Mello, C.C. & Zamore, P. D. Sequence-specific inhibition of small RNA function. PLoS Biol 2, E98 (2004).
14. Barg, S., Galvanovskis, J., Gopel, S. O., Rorsman, P. & Eliasson, L. Tight coupling between electrical activity and exocytosis in mouse glucagon-secreting alpha-cells. Diabetes 49, 1500-1510 (2000).
15. Gopel, S. O., Kanno, T., Barg, S. & Rorsman, P. Patch-clamp characterisation of omatostatin-secreting cells in intact mouse pancreatic islets. J. Physiol. 528, 497-507 (2000).
16. Tsuboi, T., da Silva Xavier, G., Leclerc, I. & Rutter, G. A. 5′-AMP-activated protein kinase controls insulin-containing secretory vesicle dynamics. J. Biol. Chem. 278, 52042-52051 (2003).
17. Rajewsky, N. & Socci, N. D. Computational identification of microRNA targets. Dev. Biol. 267, 529-535 (2004).
18. Antonin, W., Riedel, D. & von Mollard, G. F. The SNARE Vtila-β is localized to small synaptic vesicles and participates in a novel SNARE complex. J. Neurosci. 20, 5724-5732 (2000).
19. Taoka, M. et al V-1, a protein expressed transiently during murine cerebellar development, regulates actin polymerization via interaction with capping protein. J. Biol. Chem. 278, 5864-5870 (2003).
20. Larsen, C. M. et al. Interleukin-1β-induced rat pancreatic islet nitric oxide synthesis requires both the p38 and extracellular signal-regulated kinase 1/2 mitogen-activated protein kinases. J. Biol. Chem. 273, 15294-15300 (1998).
21. Zhao, C., Wilson, M. C., Schuit, F., Halestrap, A. P. & Rutter, G. A. Expression and distribution of lactate/monocarboxylate transporter isoforms in pancreatic iskts and the exocrine pancreas. Diabetes 50, 361-366 (2001).
22. Schreiber-Agus, N. et al. An amino-terminal domain of Mxil mediates anti-Myc oncogenic activity and interacts with a homolog of the yeast transcriptional represser SIN3. Cell 80, 777-786 (1995).
23. Yamakuni, T. et al. V-1, a catecholamine biosynthesis regulatory protein, positively controls catecholamine secretion in PC12D cells. FEBS Lett. 530, 94-98 (2002).
24. Lewis, B. P., Shih, I. H., Jones-Rhoades, M. W., Bartel, D. P. & Burge, C. B. Prediction of mammalian microRNA targets. Cell 115, 787-798 (2003).
25. Lagos-Quintana, M. et al. Identification of tissue-specific microRNAs from mouse. Curr. Biol. 12, 735-739 (2002).
26. Minami, K. et al. Insulin secretion and differential gene expression in glucose-responsive and -unresponsive MIN6 sublines. Am. J. Physiol. Endocrinol. Metab. 279, E773-E781 (2000).
27. Shih, D. Q. et al. Profound defects in pancreatic beta-cell function in mice with combined heterozygous mutations in Pdx-1, Hnf-1α, and Hnf-3β. Proc. Natl Acad. Sci. USA 99, 3818-3823 (2002).
28. Eliasson, L. et al. SUR1 regulates PKA-independent cAMP-inciuced granule priming in mouse pancreatic B-cells. J. Gen. Physiol. 121, 181-197 (2003).
29. Olofsson, C. S. et al. Fast insulin secretion reflects exocytosis of docked granules in mouse pancreatic B-cells. Pflugers Arch. 444, 43-51 (2002).
30. Zuker, M. Mfold web server for nucleic acid folding and hybridization prediction. Nucleic Acids Res. 31, 3406-3415 (2003).