메뉴 건너뛰기




Volumn 21, Issue 5, 2013, Pages 339-363

Pathobiology and management of prostate cancer-induced bone pain: Recent insights and future treatments

Author keywords

Analgesics; Bone metastases; Bone pain; Prostate cancer

Indexed keywords

ANALGESIC AGENT; ATRASENTAN; BISPHOSPHONIC ACID DERIVATIVE; CISPLATIN; DASATINIB; DENOSUMAB; DOCETAXEL; ENDOTHELIN 1; ETARACIZUMAB; LEXIDRONAM SAMARIUM SM 153; NARCOTIC ANALGESIC AGENT; NONSTEROID ANTIINFLAMMATORY AGENT; ODANACATIB; OPIATE; OSTEOCLAST DIFFERENTIATION FACTOR; PAMIDRONIC ACID; PHOSPHORUS 32; PLACEBO; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE KINASE INHIBITOR; RADIOISOTOPE; RADIUM 223; RHENIUM 186; RHENIUM 188; SAMARIUM 153; SARACATINIB; STRONTIUM 89; UNCLASSIFIED DRUG; UNINDEXED DRUG; ZIBOTENTAN; ZOLEDRONIC ACID;

EID: 84884813750     PISSN: 09254692     EISSN: 15685608     Source Type: Journal    
DOI: 10.1007/s10787-013-0183-7     Document Type: Review
Times cited : (35)

References (271)
  • 1
    • 0028348389 scopus 로고
    • Urokinase overproduction results in increased skeletal metastasis by prostate cancer cells in vivo
    • 8162583 1:CAS:528:DyaK2cXivFGntbw%3D
    • Achbarou A, Kaiser S, Tremblay G et al (1994) Urokinase overproduction results in increased skeletal metastasis by prostate cancer cells in vivo. Cancer Res 54:2372-2377
    • (1994) Cancer Res , vol.54 , pp. 2372-2377
    • Achbarou, A.1    Kaiser, S.2    Tremblay, G.3
  • 2
    • 0942279599 scopus 로고    scopus 로고
    • Downregulation of osteopontin and bone sialoprotein II is related to reduced colony formation and metastasis formation of MDA-MB-231 human breast cancer cells
    • 14647232 1:CAS:528:DC%2BD2cXkt1ylug%3D%3D 10.1038/sj.cgt.7700659
    • Adwan H, Bauerle TJ, Berger MR (2004) Downregulation of osteopontin and bone sialoprotein II is related to reduced colony formation and metastasis formation of MDA-MB-231 human breast cancer cells. Cancer Gene Ther 11:109-120
    • (2004) Cancer Gene Ther , vol.11 , pp. 109-120
    • Adwan, H.1    Bauerle, T.J.2    Berger, M.R.3
  • 3
    • 77956822573 scopus 로고    scopus 로고
    • Sclerostin antibody treatment enhances metaphyseal bone healing in rats
    • 20499342 1:CAS:528:DC%2BC3cXhsVOjtbzJ 10.1002/jbmr.135
    • Agholme F, Li X, Isaksson H et al (2010) Sclerostin antibody treatment enhances metaphyseal bone healing in rats. J Bone Miner Res 25:2412-2418
    • (2010) J Bone Miner Res , vol.25 , pp. 2412-2418
    • Agholme, F.1    Li, X.2    Isaksson, H.3
  • 4
    • 0037086536 scopus 로고    scopus 로고
    • A multiinstitutional, concurrent chemoradiation trial of strontium-89, estramustine, and vinblastine for hormone refractory prostate carcinoma involving bone
    • 11920525 1:CAS:528:DC%2BD38XjtVGlsL0%3D 10.1002/cncr.10437
    • Akerley W, Butera J, Wehbe T et al (2002) A multiinstitutional, concurrent chemoradiation trial of strontium-89, estramustine, and vinblastine for hormone refractory prostate carcinoma involving bone. Cancer 94:1654-1660
    • (2002) Cancer , vol.94 , pp. 1654-1660
    • Akerley, W.1    Butera, J.2    Wehbe, T.3
  • 5
    • 58149267548 scopus 로고    scopus 로고
    • Bone-targeted therapy: Phase II study of strontium-89 in combination with alternating weekly chemohormonal therapies for patients with advanced androgen-independent prostate cancer
    • 19060583 1:CAS:528:DC%2BD1cXhsVKnurnF 10.1097/COC.0b013e318172aa92
    • Amato RJ, Hernandez-McClain J, Henary H (2008) Bone-targeted therapy: phase II study of strontium-89 in combination with alternating weekly chemohormonal therapies for patients with advanced androgen-independent prostate cancer. Am J Clin Oncol 31:532-538
    • (2008) Am J Clin Oncol , vol.31 , pp. 532-538
    • Amato, R.J.1    Hernandez-Mcclain, J.2    Henary, H.3
  • 6
    • 84878871141 scopus 로고    scopus 로고
    • A phase 2 study of KX2-391, an oral inhibitor of Src kinase and tubulin polymerization, in men with bone-metastatic castration-resistant prostate cancer
    • 23314737 1:CAS:528:DC%2BC3sXkvF2nu7o%3D 10.1007/s00280-013-2079-z
    • Antonarakis ES, Heath EI, Posadas EM et al (2013) A phase 2 study of KX2-391, an oral inhibitor of Src kinase and tubulin polymerization, in men with bone-metastatic castration-resistant prostate cancer. Cancer Chemother Pharmacol 71:883-892
    • (2013) Cancer Chemother Pharmacol , vol.71 , pp. 883-892
    • Antonarakis, E.S.1    Heath, E.I.2    Posadas, E.M.3
  • 7
    • 77951496674 scopus 로고    scopus 로고
    • Dasatinib inhibits both osteoclast activation and prostate cancer PC-3-cell-induced osteoclast formation
    • 19855158 1:CAS:528:DC%2BC3cXpt1Wjs78%3D 10.4161/cbt.8.22.9770
    • Araujo JC, Poblenz A, Corn P et al (2009) Dasatinib inhibits both osteoclast activation and prostate cancer PC-3-cell-induced osteoclast formation. Cancer Biol Ther 8:2153-2159
    • (2009) Cancer Biol Ther , vol.8 , pp. 2153-2159
    • Araujo, J.C.1    Poblenz, A.2    Corn, P.3
  • 8
    • 83855162892 scopus 로고    scopus 로고
    • Dasatinib combined with docetaxel for castration-resistant prostate cancer: Results from a phase 1-2 study
    • 21976132 1:CAS:528:DC%2BC3MXhs1ajsbnN 10.1002/cncr.26204
    • Araujo JC, Mathew P, Armstrong AJ et al (2012) Dasatinib combined with docetaxel for castration-resistant prostate cancer: results from a phase 1-2 study. Cancer 118:63-71
    • (2012) Cancer , vol.118 , pp. 63-71
    • Araujo, J.C.1    Mathew, P.2    Armstrong, A.J.3
  • 9
    • 44849102368 scopus 로고    scopus 로고
    • Src kinase potentiates androgen receptor transactivation function and invasion of androgen-independent prostate cancer C4-2 cells
    • 18223692 1:CAS:528:DC%2BD1cXmslWmur0%3D 10.1038/sj.onc.1211016
    • Asim M, Siddiqui IA, Hafeez BB et al (2008) Src kinase potentiates androgen receptor transactivation function and invasion of androgen-independent prostate cancer C4-2 cells. Oncogene 27:3596-3604
    • (2008) Oncogene , vol.27 , pp. 3596-3604
    • Asim, M.1    Siddiqui, I.A.2    Hafeez, B.B.3
  • 10
    • 0032416022 scopus 로고    scopus 로고
    • Bone stem cells
    • 9893258 10.1002/(SICI)1097-4644(1998)72:30/31+<73: AID-JCB11>3.0.CO;2-L
    • Aubin JE (1998) Bone stem cells. J Cell Biochem Suppl 30-31:73-82
    • (1998) J Cell Biochem Suppl , vol.30-31 , pp. 73-82
    • Aubin, J.E.1
  • 11
    • 0034846991 scopus 로고    scopus 로고
    • Nerve growth factor modulates the activation status and fast axonal transport of ERK 1/2 in adult nociceptive neurones
    • 11520179 1:CAS:528:DC%2BD3MXmtFyqtLk%3D 10.1006/mcne.2001.1015
    • Averill S, Delcroix JD, Michael GJ et al (2001) Nerve growth factor modulates the activation status and fast axonal transport of ERK 1/2 in adult nociceptive neurones. Mol Cell Neurosci 18:183-196
    • (2001) Mol Cell Neurosci , vol.18 , pp. 183-196
    • Averill, S.1    Delcroix, J.D.2    Michael, G.J.3
  • 12
    • 34247636849 scopus 로고    scopus 로고
    • 89Sr versus 153Sm-EDTMP: Comparison of treatment efficacy of painful bone metastases in prostate and breast carcinoma
    • 17325585 10.1097/MNM.0b013e32805b72a0
    • Baczyk M, Czepczynski R, Milecki P et al (2007) 89Sr versus 153Sm-EDTMP: comparison of treatment efficacy of painful bone metastases in prostate and breast carcinoma. Nucl Med Commun 28:245-250
    • (2007) Nucl Med Commun , vol.28 , pp. 245-250
    • Baczyk, M.1    Czepczynski, R.2    Milecki, P.3
  • 13
    • 2342591450 scopus 로고    scopus 로고
    • The significance of cancer cell expression of the chemokine receptor CXCR4
    • 15246052 1:CAS:528:DC%2BD2cXjvVemsb0%3D 10.1016/j.semcancer.2003.10.003
    • Balkwill F (2004) The significance of cancer cell expression of the chemokine receptor CXCR4. Semin Cancer Biol 14:171-179
    • (2004) Semin Cancer Biol , vol.14 , pp. 171-179
    • Balkwill, F.1
  • 14
    • 0037843323 scopus 로고    scopus 로고
    • Osteoblast-related transcription factors Runx2 (Cbfa1/AML3) and MSX2 mediate the expression of bone sialoprotein in human metastatic breast cancer cells
    • 12750290 1:CAS:528:DC%2BD3sXjsleht7s%3D
    • Barnes GL, Javed A, Waller SM et al (2003) Osteoblast-related transcription factors Runx2 (Cbfa1/AML3) and MSX2 mediate the expression of bone sialoprotein in human metastatic breast cancer cells. Cancer Res 63:2631-2637
    • (2003) Cancer Res , vol.63 , pp. 2631-2637
    • Barnes, G.L.1    Javed, A.2    Waller, S.M.3
  • 15
    • 70349845440 scopus 로고    scopus 로고
    • Cellular and molecular mechanisms of pain
    • 19837031 1:CAS:528:DC%2BD1MXhsFWht7zI 10.1016/j.cell.2009.09.028
    • Basbaum AI, Bautusta DM, Scherrer G et al (2009) Cellular and molecular mechanisms of pain. Cell 139:267-284
    • (2009) Cell , vol.139 , pp. 267-284
    • Basbaum, A.I.1    Bautusta, D.M.2    Scherrer, G.3
  • 16
    • 0042707678 scopus 로고    scopus 로고
    • Interleukin-8 stimulation of osteoclastogenesis and bone resorption is a mechanism for the increased osteolysis of metastatic bone disease
    • 12919697 1:CAS:528:DC%2BD3sXmt1KjsLw%3D 10.1016/S8756-3282(03)00086-3
    • Bendre MS, Montague DC, Peery T (2003) Interleukin-8 stimulation of osteoclastogenesis and bone resorption is a mechanism for the increased osteolysis of metastatic bone disease. Bone 33:28-37
    • (2003) Bone , vol.33 , pp. 28-37
    • Bendre, M.S.1    Montague, D.C.2    Peery, T.3
  • 17
    • 0032851189 scopus 로고    scopus 로고
    • Differential patterns of bone turnover in relation to bone pain and disease extent in bone in cancer patients with skeletal metastases
    • 10430790 1:CAS:528:DyaK1MXltFGms74%3D
    • Berruti A, Dogliotti L, Gorzegno G et al (1999) Differential patterns of bone turnover in relation to bone pain and disease extent in bone in cancer patients with skeletal metastases. Clin Chem 45:1240-1247
    • (1999) Clin Chem , vol.45 , pp. 1240-1247
    • Berruti, A.1    Dogliotti, L.2    Gorzegno, G.3
  • 18
    • 38549130224 scopus 로고    scopus 로고
    • A "class action" against the microenvironment: Do cancer cells cooperate in metastasis?
    • 18066649 1:CAS:528:DC%2BD1cXhtV2gurY%3D 10.1007/s10555-007-9103-x
    • Bidard FC, Pierga JY, Vincent-Salomon A et al (2008) A "class action" against the microenvironment: do cancer cells cooperate in metastasis? Cancer Metastasis Rev 27:5-10
    • (2008) Cancer Metastasis Rev , vol.27 , pp. 5-10
    • Bidard, F.C.1    Pierga, J.Y.2    Vincent-Salomon, A.3
  • 19
    • 33845981499 scopus 로고    scopus 로고
    • Wnt signaling and osteoblastogenesis
    • 16960757 1:CAS:528:DC%2BD2sXht12mtQ%3D%3D 10.1007/s11154-006-9002-4
    • Bodine PV, Komm BS (2006) Wnt signaling and osteoblastogenesis. Rev Endocr Metab Disord 7:33-39
    • (2006) Rev Endocr Metab Disord , vol.7 , pp. 33-39
    • Bodine, P.V.1    Komm, B.S.2
  • 20
    • 0346837985 scopus 로고    scopus 로고
    • A phase i study of AMGN-0007, a recombinant osteoprotegerin construct, in patients with multiple myeloma or breast carcinoma related bone metastases
    • 12548591 10.1002/cncr.11138
    • Body JJ, Greipp P, Coleman RE et al (2003) A phase I study of AMGN-0007, a recombinant osteoprotegerin construct, in patients with multiple myeloma or breast carcinoma related bone metastases. Cancer 97:887-892
    • (2003) Cancer , vol.97 , pp. 887-892
    • Body, J.J.1    Greipp, P.2    Coleman, R.E.3
  • 21
    • 77953510486 scopus 로고    scopus 로고
    • Odanacatib, a cathepsin-K inhibitor for osteoporosis: A two-year study in postmenopausal women with low bone density
    • 19874198
    • Bone HG, McClung MR, Roux C et al (2010) Odanacatib, a cathepsin-K inhibitor for osteoporosis: a two-year study in postmenopausal women with low bone density. J Bone Miner Res 25:937-947
    • (2010) J Bone Miner Res , vol.25 , pp. 937-947
    • Bone, H.G.1    McClung, M.R.2    Roux, C.3
  • 22
    • 77955306980 scopus 로고    scopus 로고
    • Differential ATF3 expression in dorsal root ganglion neurons reveals the profile of primary afferents engaged by diverse noxious chemical stimuli
    • 20605331 1:CAS:528:DC%2BC3cXosVGrs70%3D 10.1016/j.pain.2010.05.005
    • Braz JM, Basbaum AI (2010) Differential ATF3 expression in dorsal root ganglion neurons reveals the profile of primary afferents engaged by diverse noxious chemical stimuli. Pain 150:290-301
    • (2010) Pain , vol.150 , pp. 290-301
    • Braz, J.M.1    Basbaum, A.I.2
  • 23
    • 62549089748 scopus 로고    scopus 로고
    • Dasatinib is a potent inhibitor of tumour-associated macrophages, osteoclasts and the FMS receptor
    • 18784745 1:CAS:528:DC%2BD1MXivVKgs78%3D 10.1038/leu.2008.237
    • Brownlow N, Mol C, Hayford C et al (2009) Dasatinib is a potent inhibitor of tumour-associated macrophages, osteoclasts and the FMS receptor. Leukemia 23:590-594
    • (2009) Leukemia , vol.23 , pp. 590-594
    • Brownlow, N.1    Mol, C.2    Hayford, C.3
  • 24
    • 0037302046 scopus 로고    scopus 로고
    • Cathepsin K mRNA and protein expression in prostate cancer progression
    • 12568399 1:CAS:528:DC%2BD3sXht1Sksbg%3D 10.1359/jbmr.2003.18.2.222
    • Brubaker KD, Vessella RL, True LD et al (2003) Cathepsin K mRNA and protein expression in prostate cancer progression. J Bone Miner Res 18:222-230
    • (2003) J Bone Miner Res , vol.18 , pp. 222-230
    • Brubaker, K.D.1    Vessella, R.L.2    True, L.D.3
  • 25
    • 36348960224 scopus 로고    scopus 로고
    • TGF-beta and BMP7 interactions in tumour progression and bone metastasis
    • 18008174 1:CAS:528:DC%2BD1cXhvFGgtr8%3D 10.1007/s10585-007-9118-2
    • Buijs JT, Henriquez NV, van Overveld PG et al (2007) TGF-beta and BMP7 interactions in tumour progression and bone metastasis. Clin Exp Metastasis 24:609-617
    • (2007) Clin Exp Metastasis , vol.24 , pp. 609-617
    • Buijs, J.T.1    Henriquez, N.V.2    Van Overveld, P.G.3
  • 26
    • 38549085667 scopus 로고    scopus 로고
    • The bone microenvironment in metastasis; What is special about bone?
    • 18071636 10.1007/s10555-007-9109-4
    • Bussard KM, Gay CV, Mastro AM (2008) The bone microenvironment in metastasis; what is special about bone? Cancer Metastasis Rev 27:41-55
    • (2008) Cancer Metastasis Rev , vol.27 , pp. 41-55
    • Bussard, K.M.1    Gay, C.V.2    Mastro, A.M.3
  • 27
    • 31544472056 scopus 로고    scopus 로고
    • Roles of osteonectin in the migration of breast cancer cells into bone
    • 16173048 10.1002/jcb.20644 1:CAS:528:DC%2BD28XhvFyhurY%3D
    • Campo McKnight DA, Sosnoski DM, Koblinski JE et al (2006) Roles of osteonectin in the migration of breast cancer cells into bone. J Cell Biochem 97:288-302
    • (2006) J Cell Biochem , vol.97 , pp. 288-302
    • Campo McKnight, D.A.1    Sosnoski, D.M.2    Koblinski, J.E.3
  • 28
    • 0037089676 scopus 로고    scopus 로고
    • Atrasentan, an endothelin-receptor antagonist for refractory adenocarcinomas: Safety and pharmacokinetics
    • 11956279 1:CAS:528:DC%2BD38XjvVKms7w%3D 10.1200/JCO.2002.08.028
    • Carducci MA, Nelson JB, Bowling MK et al (2002) Atrasentan, an endothelin-receptor antagonist for refractory adenocarcinomas: safety and pharmacokinetics. J Clin Oncol 20:2171-2180
    • (2002) J Clin Oncol , vol.20 , pp. 2171-2180
    • Carducci, M.A.1    Nelson, J.B.2    Bowling, M.K.3
  • 29
    • 0037441843 scopus 로고    scopus 로고
    • Effect of endothelin-A receptor blockade with atrasentan on tumor progression in men with hormone-refractory prostate cancer: A randomized, phase II, placebo-controlled trial
    • 12586806 1:CAS:528:DC%2BD2cXpsVGrurY%3D 10.1200/JCO.2003.04.176
    • Carducci MA, Padley RJ, Breul J et al (2003) Effect of endothelin-A receptor blockade with atrasentan on tumor progression in men with hormone-refractory prostate cancer: a randomized, phase II, placebo-controlled trial. J Clin Oncol 21:679-689
    • (2003) J Clin Oncol , vol.21 , pp. 679-689
    • Carducci, M.A.1    Padley, R.J.2    Breul, J.3
  • 30
    • 35648968713 scopus 로고    scopus 로고
    • A phase 3 randomized controlled trial of the efficacy and safety of atrasentan in men with metastatic hormone-refractory prostate cancer
    • 17886253 1:CAS:528:DC%2BD2sXhtlertbrP 10.1002/cncr.22996
    • Carducci MA, Saad F, Abrahamsson PA et al (2007) A phase 3 randomized controlled trial of the efficacy and safety of atrasentan in men with metastatic hormone-refractory prostate cancer. Cancer 110:1959-1966
    • (2007) Cancer , vol.110 , pp. 1959-1966
    • Carducci, M.A.1    Saad, F.2    Abrahamsson, P.A.3
  • 31
    • 69249206543 scopus 로고    scopus 로고
    • The critical role of the bone microenvironment in cancer metastases
    • 19616059 1:CAS:528:DC%2BD1MXhtVKlsrzO 10.1016/j.mce.2009.07.004
    • Casimiro S, Guise TA, Chirgwin J (2009) The critical role of the bone microenvironment in cancer metastases. Mol Cell Endocrinol 310:71-81
    • (2009) Mol Cell Endocrinol , vol.310 , pp. 71-81
    • Casimiro, S.1    Guise, T.A.2    Chirgwin, J.3
  • 32
    • 79952614068 scopus 로고    scopus 로고
    • The role of RANK-ligand inhibition in cancer: The story of denosumab
    • 21285392 1:CAS:528:DC%2BC3MXksFKitro%3D 10.1634/theoncologist.2010-0154
    • Castellano D, Sepulveda JM, Garcia-Escobar I et al (2011) The role of RANK-ligand inhibition in cancer: the story of denosumab. Oncologist 16:136-145
    • (2011) Oncologist , vol.16 , pp. 136-145
    • Castellano, D.1    Sepulveda, J.M.2    Garcia-Escobar, I.3
  • 33
    • 0034646740 scopus 로고    scopus 로고
    • Impaired nociception and pain sensation in mice lacking the capsaicin receptor
    • 10764638 1:CAS:528:DC%2BD3cXislersr8%3D 10.1126/science.288.5464.306
    • Caterina MJ, Leffler A, Malmberg AB et al (2000) Impaired nociception and pain sensation in mice lacking the capsaicin receptor. Science 288:306-313
    • (2000) Science , vol.288 , pp. 306-313
    • Caterina, M.J.1    Leffler, A.2    Malmberg, A.B.3
  • 34
    • 54549086723 scopus 로고    scopus 로고
    • Src family kinase oncogenic potential and pathways in prostate cancer as revealed by AZD0530
    • 18679417 1:CAS:528:DC%2BD1cXht1Ont7fN 10.1038/onc.2008.250
    • Chang YM, Bai L, Liu S et al (2008) Src family kinase oncogenic potential and pathways in prostate cancer as revealed by AZD0530. Oncogene 27:6365-6375
    • (2008) Oncogene , vol.27 , pp. 6365-6375
    • Chang, Y.M.1    Bai, L.2    Liu, S.3
  • 35
    • 33745821237 scopus 로고    scopus 로고
    • Expression of RANKL/RANK/OPG in primary and metastatic human prostate cancer as markers of disease stage and functional regulation
    • 16752412 1:CAS:528:DC%2BD28Xnsl2mtL0%3D 10.1002/cncr.21978
    • Chen G, Sircar K, Aprikian A et al (2006) Expression of RANKL/RANK/OPG in primary and metastatic human prostate cancer as markers of disease stage and functional regulation. Cancer 107:289-298
    • (2006) Cancer , vol.107 , pp. 289-298
    • Chen, G.1    Sircar, K.2    Aprikian, A.3
  • 36
    • 36849060195 scopus 로고    scopus 로고
    • Skeletal metastases: Decreasing tumor burden by targeting the bone microenvironment
    • 17907152 1:CAS:528:DC%2BD2sXhsVeit7fK 10.1002/jcb.21556
    • Chirgwin JM, Guise TA (2007) Skeletal metastases: decreasing tumor burden by targeting the bone microenvironment. J Cell Biochem 102:1333-1342
    • (2007) J Cell Biochem , vol.102 , pp. 1333-1342
    • Chirgwin, J.M.1    Guise, T.A.2
  • 37
    • 27844604914 scopus 로고    scopus 로고
    • Painful bone metastases: A prospective observational cohort study
    • 16295283 10.1191/0269216305pm1079oa
    • Clare C, Royle D, Saharia K et al (2005) Painful bone metastases: a prospective observational cohort study. Palliat Med 19:521-525
    • (2005) Palliat Med , vol.19 , pp. 521-525
    • Clare, C.1    Royle, D.2    Saharia, K.3
  • 38
    • 58149387662 scopus 로고    scopus 로고
    • Normal bone anatomy and physiology
    • 18988698 1:CAS:528:DC%2BD1cXhsVemtrbO 10.2215/CJN.04151206
    • Clarke B (2008) Normal bone anatomy and physiology. Clin J Am Soc Nephrol 3(Suppl 3):S131-S139
    • (2008) Clin J Am Soc Nephrol , vol.3 , Issue.SUPPL. 3
    • Clarke, B.1
  • 39
    • 37349111484 scopus 로고    scopus 로고
    • The pharmacologic management of cancer pain
    • 18095817 10.1089/jpm.2007.9842
    • Cleary JF (2007) The pharmacologic management of cancer pain. J Palliat Med 10:1369-1394
    • (2007) J Palliat Med , vol.10 , pp. 1369-1394
    • Cleary, J.F.1
  • 40
    • 78650304661 scopus 로고    scopus 로고
    • Bisphosphonates' antitumor activity: An unravelled side of a multifaceted drug class
    • 20655399 1:CAS:528:DC%2BC3cXhs1Wgu7rF 10.1016/j.bone.2010.07.016
    • Clezardin P (2011) Bisphosphonates' antitumor activity: an unravelled side of a multifaceted drug class. Bone 48:71-79
    • (2011) Bone , vol.48 , pp. 71-79
    • Clezardin, P.1
  • 41
    • 40649090942 scopus 로고    scopus 로고
    • Molecular mechanisms and treatment of bone metastasis
    • 18321396 10.1017/S1462399408000616
    • Clines GA, Guise TA (2008) Molecular mechanisms and treatment of bone metastasis. Expert Rev Mol Med 10:e7
    • (2008) Expert Rev Mol Med , vol.10 , pp. 7
    • Clines, G.A.1    Guise, T.A.2
  • 42
    • 33846624243 scopus 로고    scopus 로고
    • Dickkopf homolog 1 mediates endothelin-1-stimulated new bone formation
    • 17068196 1:CAS:528:DC%2BD2sXhsVWisbo%3D 10.1210/me.2006-0346
    • Clines GA, Mohammad KS, Bao Y et al (2007) Dickkopf homolog 1 mediates endothelin-1-stimulated new bone formation. Mol Endocrinol 21:486-498
    • (2007) Mol Endocrinol , vol.21 , pp. 486-498
    • Clines, G.A.1    Mohammad, K.S.2    Bao, Y.3
  • 43
    • 0034926222 scopus 로고    scopus 로고
    • Pamidronate decreases tumor-induced osteoclastogenesis in osteopetrotic mice
    • 11518261 1:CAS:528:DC%2BD3MXmvVaiurs%3D 10.1016/S0736-0266(00)00065-6
    • Clohisy DR, O' Keefe PF, Ramnaraine ML (2001) Pamidronate decreases tumor-induced osteoclastogenesis in osteopetrotic mice. J Orthop Res 19:554-558
    • (2001) J Orthop Res , vol.19 , pp. 554-558
    • Clohisy, D.R.1    Keefe P F, O.'.2    Ramnaraine, M.L.3
  • 44
    • 0026786361 scopus 로고
    • Integrin subunit expression by human osteoblasts and osteoclasts in situ and in culture
    • 1429908 1:CAS:528:DyaK3sXjs1Chsg%3D%3D
    • Clover J, Dodds RA, Gowen M (1992) Integrin subunit expression by human osteoblasts and osteoclasts in situ and in culture. J Cell Sci 103:267-271
    • (1992) J Cell Sci , vol.103 , pp. 267-271
    • Clover, J.1    Dodds, R.A.2    Gowen, M.3
  • 45
    • 0028048974 scopus 로고
    • Biological effects of prostate specific antigen as an insulin-like growth factor binding protein-3 protease
    • 7525824 1:CAS:528:DyaK2cXlvFKrs7Y%3D 10.1677/joe.0.1420407
    • Cohen P, Peehl DM, Graves HC et al (1994) Biological effects of prostate specific antigen as an insulin-like growth factor binding protein-3 protease. J Endocrinol 142:407-415
    • (1994) J Endocrinol , vol.142 , pp. 407-415
    • Cohen, P.1    Peehl, D.M.2    Graves, H.C.3
  • 46
    • 33750726077 scopus 로고    scopus 로고
    • Clinical features of metastatic bone disease and risk of skeletal morbidity
    • 17062708 10.1158/1078-0432.CCR-06-0931
    • Coleman RE (2006) Clinical features of metastatic bone disease and risk of skeletal morbidity. Clin Cancer Res 12:6243s-6249s
    • (2006) Clin Cancer Res , vol.12
    • Coleman, R.E.1
  • 47
    • 0030211390 scopus 로고    scopus 로고
    • Prostate specific antigen cleaves parathyroid hormone-related protein in the PTH-like domain: Inactivation of PTHrP-stimulated cAMP accumulation in mouse osteoblasts
    • 8683730 1:CAS:528:DyaK28XkvFartLs%3D 10.1016/S0022-5347(01)65919-6
    • Cramer SD, Chen Z, Peehl DM (1996) Prostate specific antigen cleaves parathyroid hormone-related protein in the PTH-like domain: inactivation of PTHrP-stimulated cAMP accumulation in mouse osteoblasts. J Urol 156:526-531
    • (1996) J Urol , vol.156 , pp. 526-531
    • Cramer, S.D.1    Chen, Z.2    Peehl, D.M.3
  • 48
    • 70349754434 scopus 로고    scopus 로고
    • The neuroendocrine-derived peptide parathyroid hormone-related protein promotes prostate cancer cell growth by stabilizing the androgen receptor
    • 19706771 1:CAS:528:DC%2BD1MXhtFaku7vP 10.1158/0008-5472.CAN-08-4687
    • DaSilva J, Gioeli D, Weber MJ et al (2009) The neuroendocrine-derived peptide parathyroid hormone-related protein promotes prostate cancer cell growth by stabilizing the androgen receptor. Cancer Res 69:7402-7411
    • (2009) Cancer Res , vol.69 , pp. 7402-7411
    • Dasilva, J.1    Gioeli, D.2    Weber, M.J.3
  • 49
    • 84861014659 scopus 로고    scopus 로고
    • Characterization of a rat model of metastatic prostate cancer bone pain
    • 21197325
    • De Ciantis PD, Yashpal K, Henry J et al (2010) Characterization of a rat model of metastatic prostate cancer bone pain. J Pain Res 3:213-221
    • (2010) J Pain Res , vol.3 , pp. 213-221
    • De Ciantis, P.D.1    Yashpal, K.2    Henry, J.3
  • 50
    • 33947413459 scopus 로고    scopus 로고
    • Mechanisms of osteopontin and CD44 as metastatic principles in prostate cancer cells
    • 17343740 10.1186/1476-4598-6-18 1:CAS:528:DC%2BD2sXjsl2rsLk%3D
    • Desai B, Rogers MJ, Chellaiah MA (2007) Mechanisms of osteopontin and CD44 as metastatic principles in prostate cancer cells. Mol Cancer 6:18
    • (2007) Mol Cancer , vol.6 , pp. 18
    • Desai, B.1    Rogers, M.J.2    Chellaiah, M.A.3
  • 51
    • 33845948289 scopus 로고    scopus 로고
    • Prospective evaluation of samarium-153-EDTMP radionuclide treatment for bone metastases in patients with hormone-refractory prostate cancer
    • 17192733 1:CAS:528:DC%2BD28XhtlGnt7jJ 10.1159/000096935
    • Dolezal J, Vizda J, Odrazka K (2007) Prospective evaluation of samarium-153-EDTMP radionuclide treatment for bone metastases in patients with hormone-refractory prostate cancer. Urol Int 78:50-57
    • (2007) Urol Int , vol.78 , pp. 50-57
    • Dolezal, J.1    Vizda, J.2    Odrazka, K.3
  • 52
    • 1842713361 scopus 로고    scopus 로고
    • Superficial dorsal horn neuronal responses and the emergence of behavioural hyperalgesia in a rat model of cancer-induced bone pain
    • 15082171 1:CAS:528:DC%2BD2cXjtV2ntrs%3D 10.1016/j.neulet.2004.01.048
    • Donovan-Rodriguez T, Dickenson AH, Urch CE (2004) Superficial dorsal horn neuronal responses and the emergence of behavioural hyperalgesia in a rat model of cancer-induced bone pain. Neurosci Lett 360:29-32
    • (2004) Neurosci Lett , vol.360 , pp. 29-32
    • Donovan-Rodriguez, T.1    Dickenson, A.H.2    Urch, C.E.3
  • 53
    • 0033568341 scopus 로고    scopus 로고
    • RANK is essential for osteoclast and lymph node development
    • 10500098 1:CAS:528:DyaK1MXmsVCgtr4%3D 10.1101/gad.13.18.2412
    • Dougall WC, Glaccum M, Charrier K et al (1999) RANK is essential for osteoclast and lymph node development. Genes Dev 13:2412-2424
    • (1999) Genes Dev , vol.13 , pp. 2412-2424
    • Dougall, W.C.1    Glaccum, M.2    Charrier, K.3
  • 54
    • 1242286471 scopus 로고    scopus 로고
    • Effects of physiological concentrations of steroid hormones and interleukin-11 on basal and stimulated production of interleukin-8 by human osteoblast-like cells with different functional profiles
    • 15005008 1:STN:280:DC%2BD2c7hsFOktg%3D%3D
    • Dovio A, Sartori ML, Masera RG et al (2004) Effects of physiological concentrations of steroid hormones and interleukin-11 on basal and stimulated production of interleukin-8 by human osteoblast-like cells with different functional profiles. Clin Exp Rheumatol 22:79-84
    • (2004) Clin Exp Rheumatol , vol.22 , pp. 79-84
    • Dovio, A.1    Sartori, M.L.2    Masera, R.G.3
  • 55
    • 70349920691 scopus 로고    scopus 로고
    • A short treatment with an antibody to sclerostin can inhibit bone loss in an ongoing model of colitis
    • 19419292 1:CAS:528:DC%2BD1MXhtlGgurfM 10.1359/jbmr.090403
    • Eddleston A, Marenzana M, Moore AR et al (2009) A short treatment with an antibody to sclerostin can inhibit bone loss in an ongoing model of colitis. J Bone Miner Res 24:1662-1671
    • (2009) J Bone Miner Res , vol.24 , pp. 1662-1671
    • Eddleston, A.1    Marenzana, M.2    Moore, A.R.3
  • 56
    • 0027987231 scopus 로고
    • Efficacy and safety of nonsteroidal antiinflammatory drugs for cancer pain: A meta-analysis
    • 7989953 1:STN:280:DyaK2M%2FotFyhsg%3D%3D
    • Eisenberg E, Berkey CS, Carr DB et al (1994) Efficacy and safety of nonsteroidal antiinflammatory drugs for cancer pain: a meta-analysis. J Clin Oncol 12:2756-2765
    • (1994) J Clin Oncol , vol.12 , pp. 2756-2765
    • Eisenberg, E.1    Berkey, C.S.2    Carr, D.B.3
  • 57
    • 78049522060 scopus 로고    scopus 로고
    • Odanacatib in the treatment of postmenopausal women with low bone mineral density: Three-year continued therapy and resolution of effect
    • 20740685 1:CAS:528:DC%2BC3MXjt1Wru7g%3D 10.1002/jbmr.212
    • Eisman JA, Bone HG, Hosking DJ et al (2011) Odanacatib in the treatment of postmenopausal women with low bone mineral density: three-year continued therapy and resolution of effect. J Bone Miner Res 26:242-251
    • (2011) J Bone Miner Res , vol.26 , pp. 242-251
    • Eisman, J.A.1    Bone, H.G.2    Hosking, D.J.3
  • 58
    • 70349420282 scopus 로고    scopus 로고
    • International patterns of practice in palliative radiotherapy for painful bone metastases: Evidence-based practice?
    • 19464820 10.1016/j.ijrobp.2008.12.084
    • Fairchild A, Barnes E, Ghosh S et al (2009) International patterns of practice in palliative radiotherapy for painful bone metastases: evidence-based practice? Int J Radiat Oncol Biol Phys 75:1501-1510
    • (2009) Int J Radiat Oncol Biol Phys , vol.75 , pp. 1501-1510
    • Fairchild, A.1    Barnes, E.2    Ghosh, S.3
  • 59
    • 84884816393 scopus 로고    scopus 로고
    • FDA Accessed 16 Feb 2013
    • ® (dasatinib) Tablet. http://www.accessdata.fda.gov/drugsatfda-docs/label/2010/021986s7s8lbl.pdf. Accessed 16 Feb 2013
    • (2010) ® (Dasatinib) Tablet
  • 60
    • 31544464054 scopus 로고    scopus 로고
    • Overexpression of noggin inhibits BMP-mediated growth of osteolytic prostate cancer lesions
    • 16126463 1:CAS:528:DC%2BD28XhtFartbs%3D 10.1016/j.bone.2005.07.015
    • Feeley BT, Krenek L, Liu N et al (2006) Overexpression of noggin inhibits BMP-mediated growth of osteolytic prostate cancer lesions. Bone 38:154-166
    • (2006) Bone , vol.38 , pp. 154-166
    • Feeley, B.T.1    Krenek, L.2    Liu, N.3
  • 61
    • 78049485263 scopus 로고    scopus 로고
    • Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008
    • 21351269 1:CAS:528:DC%2BC3cXhtlWhs7fO 10.1002/ijc.25516
    • Ferlay J, Shin HR, Bray F et al (2010) Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer 127:2893-2917
    • (2010) Int J Cancer , vol.127 , pp. 2893-2917
    • Ferlay, J.1    Shin, H.R.2    Bray, F.3
  • 62
    • 79952360832 scopus 로고    scopus 로고
    • Denosumab versus zoledronic acid for treatment of bone metastases in men with castration-resistant prostate cancer: A randomised, double-blind study
    • 21353695 1:CAS:528:DC%2BC3MXjsVyrt70%3D 10.1016/S0140-6736(10)62344-6
    • Fizazi K, Carducci M, Smith M et al (2011) Denosumab versus zoledronic acid for treatment of bone metastases in men with castration-resistant prostate cancer: a randomised, double-blind study. Lancet 377:813-822
    • (2011) Lancet , vol.377 , pp. 813-822
    • Fizazi, K.1    Carducci, M.2    Smith, M.3
  • 63
    • 51049096601 scopus 로고    scopus 로고
    • Central neuronal mechanisms in cancer-induced bone pain
    • 18660717 10.1097/SPC.0b013e328133f5e9
    • Gordon-Williams RM, Dickenson AH (2007) Central neuronal mechanisms in cancer-induced bone pain. Curr Opin Support Palliat Care 1:6-10
    • (2007) Curr Opin Support Palliat Care , vol.1 , pp. 6-10
    • Gordon-Williams, R.M.1    Dickenson, A.H.2
  • 64
    • 84863093187 scopus 로고    scopus 로고
    • Bone-targeting radiopharmaceuticals for the treatment of prostate cancer with bone metastases
    • 22521546 1:CAS:528:DC%2BC38Xms1Wqs7o%3D 10.1016/j.canlet.2012.04.001
    • Goyal J, Antonarakis ES (2012) Bone-targeting radiopharmaceuticals for the treatment of prostate cancer with bone metastases. Cancer Lett 323:135-146
    • (2012) Cancer Lett , vol.323 , pp. 135-146
    • Goyal, J.1    Antonarakis, E.S.2
  • 65
    • 34948886119 scopus 로고    scopus 로고
    • Effects of vitaxin, a novel therapeutic in trial for metastatic bone tumors, on osteoclast functions in vitro
    • 17390341 1:CAS:528:DC%2BD2sXhtFKjtLbO 10.1002/jcb.21296
    • Gramoun A, Shorey S, Bashutski JD et al (2007) Effects of vitaxin, a novel therapeutic in trial for metastatic bone tumors, on osteoclast functions in vitro. J Cell Biochem 102:341-352
    • (2007) J Cell Biochem , vol.102 , pp. 341-352
    • Gramoun, A.1    Shorey, S.2    Bashutski, J.D.3
  • 66
    • 0142250340 scopus 로고    scopus 로고
    • Transforming growth factor-beta in osteolytic breast cancer bone metastases
    • 14600590 10.1097/01.blo.0000093055.96273.69
    • Guise TA, Chirgwin JM (2003) Transforming growth factor-beta in osteolytic breast cancer bone metastases. Clin Orthop Relat Res 415(Suppl):S32-S38
    • (2003) Clin Orthop Relat Res , vol.415 , Issue.SUPPL.
    • Guise, T.A.1    Chirgwin, J.M.2
  • 67
    • 34249795149 scopus 로고    scopus 로고
    • Glial-cytokine-neuronal interactions underlying the mechanisms of persistent pain
    • 17537972 1:CAS:528:DC%2BD2sXmsVWkt7k%3D 10.1523/JNEUROSCI.0176-07.2007
    • Guo W, Wang H, Watanabe M et al (2007) Glial-cytokine-neuronal interactions underlying the mechanisms of persistent pain. J Neurosci 27:6006-6018
    • (2007) J Neurosci , vol.27 , pp. 6006-6018
    • Guo, W.1    Wang, H.2    Watanabe, M.3
  • 68
    • 58149347812 scopus 로고    scopus 로고
    • Differential activation of spinal cord glial cells in murine models of neuropathic and cancer pain
    • 18499488 1:CAS:528:DC%2BD1MXntVCkug%3D%3D 10.1016/j.ejpain.2008.03.014
    • Hald A, Nedergaard S, Hansen RR et al (2009) Differential activation of spinal cord glial cells in murine models of neuropathic and cancer pain. Eur J Pain 13:138-145
    • (2009) Eur J Pain , vol.13 , pp. 138-145
    • Hald, A.1    Nedergaard, S.2    Hansen, R.R.3
  • 69
    • 0028096180 scopus 로고
    • Effect of the bisphosphonate risedronate on bone metastases in a rat mammary adenocarcinoma model system
    • 8140935 1:CAS:528:DyaK2cXivV2ms7c%3D 10.1002/jbmr.5650090211
    • Hall DG, Stoica G (1994) Effect of the bisphosphonate risedronate on bone metastases in a rat mammary adenocarcinoma model system. J Bone Miner Res 9:221-230
    • (1994) J Bone Miner Res , vol.9 , pp. 221-230
    • Hall, D.G.1    Stoica, G.2
  • 70
    • 50949117119 scopus 로고    scopus 로고
    • Dickkopf-1 expression increases early in prostate cancer development and decreases during progression from primary tumor to metastasis
    • 18561248 10.1002/pros.20805
    • Hall CL, Daignault SD, Shah RB et al (2008) Dickkopf-1 expression increases early in prostate cancer development and decreases during progression from primary tumor to metastasis. Prostate 68:1396-1404
    • (2008) Prostate , vol.68 , pp. 1396-1404
    • Hall, C.L.1    Daignault, S.D.2    Shah, R.B.3
  • 71
    • 27144433512 scopus 로고    scopus 로고
    • A blocking antibody to nerve growth factor attenuates skeletal pain induced by prostate tumor cells growing in bone
    • 16230406 1:CAS:528:DC%2BD2MXhtFWmu73J 10.1158/0008-5472.CAN-05-0826
    • Halvorson KG, Kubota K, Sevcik MA et al (2005) A blocking antibody to nerve growth factor attenuates skeletal pain induced by prostate tumor cells growing in bone. Cancer Res 65:9426-9435
    • (2005) Cancer Res , vol.65 , pp. 9426-9435
    • Halvorson, K.G.1    Kubota, K.2    Sevcik, M.A.3
  • 72
    • 0035383761 scopus 로고    scopus 로고
    • Macrophage inflammatory protein-1alpha is an osteoclastogenic factor in myeloma that is independent of receptor activator of nuclear factor kappaB ligand
    • 11369623 1:CAS:528:DC%2BD3MXktFOkt7o%3D 10.1182/blood.V97.11.3349
    • Han JH, Choi SJ, Kurihara N et al (2001) Macrophage inflammatory protein-1alpha is an osteoclastogenic factor in myeloma that is independent of receptor activator of nuclear factor kappaB ligand. Blood 97:3349-3353
    • (2001) Blood , vol.97 , pp. 3349-3353
    • Han, J.H.1    Choi, S.J.2    Kurihara, N.3
  • 73
    • 0036733694 scopus 로고    scopus 로고
    • The PLACORHEN study: A double-blind, placebo-controlled, randomized radionuclide study with (186)Re-etidronate in hormone-resistant prostate cancer patients with painful bone metastases. Placebo Controlled Rhenium Study
    • 12215552 1:CAS:528:DC%2BD38Xns1elsr0%3D
    • Han SH, de Klerk JM, Tan S et al (2002) The PLACORHEN study: a double-blind, placebo-controlled, randomized radionuclide study with (186)Re-etidronate in hormone-resistant prostate cancer patients with painful bone metastases. Placebo Controlled Rhenium Study. J Nucl Med 43:1150-1156
    • (2002) J Nucl Med , vol.43 , pp. 1150-1156
    • Han, S.H.1    De Klerk, J.M.2    Tan, S.3
  • 74
    • 77953433829 scopus 로고    scopus 로고
    • Effects of the Src kinase inhibitor saracatinib (AZD0530) on bone turnover in healthy men: A randomized, double-blind, placebo-controlled, multiple-ascending-dose phase i trial
    • 19775203 1:CAS:528:DC%2BC3cXksl2ltbg%3D 10.1359/jbmr.090830
    • Hannon RA, Clack G, Rimmer M et al (2010) Effects of the Src kinase inhibitor saracatinib (AZD0530) on bone turnover in healthy men: a randomized, double-blind, placebo-controlled, multiple-ascending-dose phase I trial. J Bone Miner Res 25:463-471
    • (2010) J Bone Miner Res , vol.25 , pp. 463-471
    • Hannon, R.A.1    Clack, G.2    Rimmer, M.3
  • 75
    • 0025768485 scopus 로고
    • Macrophage colony stimulating factor (M-CSF) is essential for osteoclast formation in vitro
    • 2043138 1:CAS:528:DyaK3MXlt1ynsbk%3D 10.1016/0006-291X(91)92015-C
    • Hattersley G, Owens J, Flanagan AM et al (1991) Macrophage colony stimulating factor (M-CSF) is essential for osteoclast formation in vitro. Biochem Biophys Res Commun 177:526-531
    • (1991) Biochem Biophys Res Commun , vol.177 , pp. 526-531
    • Hattersley, G.1    Owens, J.2    Flanagan, A.M.3
  • 76
    • 77950882020 scopus 로고    scopus 로고
    • The CXCR4/SDF-1 chemokine axis: A potential therapeutic target for bone metastases?
    • 20166978 1:CAS:528:DC%2BC3cXlvFymuro%3D 10.2174/138161210791034012
    • Hirbe AC, Morgan EA, Weilbaecher KN (2010) The CXCR4/SDF-1 chemokine axis: a potential therapeutic target for bone metastases? Curr Pharm Des 16:1284-1290
    • (2010) Curr Pharm des , vol.16 , pp. 1284-1290
    • Hirbe, A.C.1    Morgan, E.A.2    Weilbaecher, K.N.3
  • 77
    • 0037086077 scopus 로고    scopus 로고
    • Osteoprotegerin (OPG) is a survival factor for human prostate cancer cells
    • 11912131 1:CAS:528:DC%2BD38XisVSisLw%3D
    • Holen I, Croucher PI, Hamdy FC et al (2002) Osteoprotegerin (OPG) is a survival factor for human prostate cancer cells. Cancer Res 62:1619-1623
    • (2002) Cancer Res , vol.62 , pp. 1619-1623
    • Holen, I.1    Croucher, P.I.2    Hamdy, F.C.3
  • 78
    • 0034130227 scopus 로고    scopus 로고
    • Murine models of inflammatory, neuropathic and cancer pain each generates a unique set of neurochemical changes in the spinal cord and sensory neurons
    • 10869852 1:CAS:528:DC%2BD3cXktlKnt7w%3D 10.1016/S0306-4522(00)00110-X
    • Honore P, Rogers SD, Schwei MJ et al (2000a) Murine models of inflammatory, neuropathic and cancer pain each generates a unique set of neurochemical changes in the spinal cord and sensory neurons. Neuroscience 98:585-598
    • (2000) Neuroscience , vol.98 , pp. 585-598
    • Honore, P.1    Rogers, S.D.2    Schwei, M.J.3
  • 79
    • 0034589740 scopus 로고    scopus 로고
    • Cellular and neurochemical remodeling of the spinal cord in bone cancer pain
    • 11098706 1:STN:280:DC%2BD3M%2FmtFGgsA%3D%3D 10.1016/S0079-6123(00)29030-4
    • Honore P, Schwei J, Rogers SD et al (2000b) Cellular and neurochemical remodeling of the spinal cord in bone cancer pain. Prog Brain Res 129:389-397
    • (2000) Prog Brain Res , vol.129 , pp. 389-397
    • Honore, P.1    Schwei, J.2    Rogers, S.D.3
  • 80
    • 0026488404 scopus 로고
    • Osteoclasts express high levels of pp 60c-src in association with intracellular membranes
    • 1385441 1:CAS:528:DyaK3sXjs1WlsA%3D%3D 10.1083/jcb.119.4.1003
    • Horne WC, Neff L, Chatterjee D et al (1992) Osteoclasts express high levels of pp 60c-src in association with intracellular membranes. J Cell Biol 119:1003-1013
    • (1992) J Cell Biol , vol.119 , pp. 1003-1013
    • Horne, W.C.1    Neff, L.2    Chatterjee, D.3
  • 81
    • 16844364795 scopus 로고    scopus 로고
    • Human osteocalcin and bone sialoprotein mediating osteomimicry of prostate cancer cells: Role of cAMP-dependent protein kinase A signaling pathway
    • 15781644 1:CAS:528:DC%2BD2MXisFGnsrs%3D 10.1158/0008-5472.CAN-04-3448
    • Huang WC, Xie Z, Konaka H et al (2005) Human osteocalcin and bone sialoprotein mediating osteomimicry of prostate cancer cells: role of cAMP-dependent protein kinase A signaling pathway. Cancer Res 65:2303-2313
    • (2005) Cancer Res , vol.65 , pp. 2303-2313
    • Huang, W.C.1    Xie, Z.2    Konaka, H.3
  • 82
    • 41149153802 scopus 로고    scopus 로고
    • Phosphorylation of sodium channel Na(v)1.8 by p38 mitogen-activated protein kinase increases current density in dorsal root ganglion neurons
    • 18354022 1:CAS:528:DC%2BD1cXjvFCjtr8%3D 10.1523/JNEUROSCI.4403-07.2008
    • Hudmon A, Choi JS, Tyrrell L et al (2008) Phosphorylation of sodium channel Na(v)1.8 by p38 mitogen-activated protein kinase increases current density in dorsal root ganglion neurons. J Neurosci 28:3190-3201
    • (2008) J Neurosci , vol.28 , pp. 3190-3201
    • Hudmon, A.1    Choi, J.S.2    Tyrrell, L.3
  • 84
    • 77949347731 scopus 로고    scopus 로고
    • Pathogenesis of osteoblastic bone metastases from prostate cancer
    • 20108337 1:CAS:528:DC%2BC3cXktFGgs7c%3D 10.1002/cncr.24896
    • Ibrahim T, Flamini E, Mercatali L et al (2010) Pathogenesis of osteoblastic bone metastases from prostate cancer. Cancer 116:1406-1418
    • (2010) Cancer , vol.116 , pp. 1406-1418
    • Ibrahim, T.1    Flamini, E.2    Mercatali, L.3
  • 85
    • 62649134676 scopus 로고    scopus 로고
    • Safety and efficacy of the specific endothelin-A receptor antagonist ZD4054 in patients with hormone-resistant prostate cancer and bone metastases who were pain free or mildly symptomatic: A double-blind, placebo-controlled, randomised, phase 2 trial
    • 19042080 1:CAS:528:DC%2BD1MXnvF2qtrk%3D 10.1016/j.eururo.2008.11.002
    • James ND, Caty A, Borre M et al (2009) Safety and efficacy of the specific endothelin-A receptor antagonist ZD4054 in patients with hormone-resistant prostate cancer and bone metastases who were pain free or mildly symptomatic: a double-blind, placebo-controlled, randomised, phase 2 trial. Eur Urol 55:1112-1123
    • (2009) Eur Urol , vol.55 , pp. 1112-1123
    • James, N.D.1    Caty, A.2    Borre, M.3
  • 86
    • 33846457870 scopus 로고    scopus 로고
    • Cancer statistics, 2007
    • 17237035 10.3322/canjclin.57.1.43
    • Jemal A, Siegel R, Ward E et al (2007) Cancer statistics, 2007. CA Cancer J Clin 57:43-66
    • (2007) CA Cancer J Clin , vol.57 , pp. 43-66
    • Jemal, A.1    Siegel, R.2    Ward, E.3
  • 87
    • 79952278967 scopus 로고    scopus 로고
    • The cathepsin K inhibitor odanacatib suppresses bone resorption in women with breast cancer and established bone metastases: Results of a 4-week, double-blind, randomized, controlled trial
    • 21147688 1:CAS:528:DC%2BC3MXjslCksA%3D%3D 10.3816/CBC.2010.n.059
    • Jensen AB, Wynne C, Ramirez G et al (2010) The cathepsin K inhibitor odanacatib suppresses bone resorption in women with breast cancer and established bone metastases: results of a 4-week, double-blind, randomized, controlled trial. Clin Breast Cancer 10:452-458
    • (2010) Clin Breast Cancer , vol.10 , pp. 452-458
    • Jensen, A.B.1    Wynne, C.2    Ramirez, G.3
  • 88
    • 0037179755 scopus 로고    scopus 로고
    • P38 MAPK activation by NGF in primary sensory neurons after inflammation increases TRPV1 levels and maintains heat hyperalgesia
    • 12367506 1:CAS:528:DC%2BD38XnvVGns7s%3D 10.1016/S0896-6273(02)00908-X
    • Ji RR, Samad TA, Jin SX et al (2002) p38 MAPK activation by NGF in primary sensory neurons after inflammation increases TRPV1 levels and maintains heat hyperalgesia. Neuron 36:57-68
    • (2002) Neuron , vol.36 , pp. 57-68
    • Ji, R.R.1    Samad, T.A.2    Jin, S.X.3
  • 89
    • 78049509543 scopus 로고    scopus 로고
    • Pathological sprouting of adult nociceptors in chronic prostate cancer-induced bone pain
    • 21048122 1:CAS:528:DC%2BC3cXhsVGqtbrF 10.1523/JNEUROSCI.3300-10.2010
    • Jimenez-Andrade JM, Bloom AP, Stake JI et al (2010a) Pathological sprouting of adult nociceptors in chronic prostate cancer-induced bone pain. J Neurosci 30:14649-14656
    • (2010) J Neurosci , vol.30 , pp. 14649-14656
    • Jimenez-Andrade, J.M.1    Bloom, A.P.2    Stake, J.I.3
  • 91
    • 80054988003 scopus 로고    scopus 로고
    • Preventive or late administration of anti-NGF therapy attenuates tumor-induced nerve sprouting, neuroma formation, and cancer pain
    • 21907491 1:CAS:528:DC%2BC3MXhtlOnsbnF 10.1016/j.pain.2011.07.020
    • Jimenez-Andrade JM, Ghilardi JR, Castaneda-Corral G et al (2011) Preventive or late administration of anti-NGF therapy attenuates tumor-induced nerve sprouting, neuroma formation, and cancer pain. Pain 152:2564-2574
    • (2011) Pain , vol.152 , pp. 2564-2574
    • Jimenez-Andrade, J.M.1    Ghilardi, J.R.2    Castaneda-Corral, G.3
  • 92
    • 79953326119 scopus 로고    scopus 로고
    • Steps in prostate cancer progression that lead to bone metastasis
    • 21365645 1:CAS:528:DC%2BC3MXktVSgtL8%3D 10.1002/ijc.26024
    • Jin JK, Dayyani F, Gallick GE (2011) Steps in prostate cancer progression that lead to bone metastasis. Int J Cancer 128:2545-2561
    • (2011) Int J Cancer , vol.128 , pp. 2545-2561
    • Jin, J.K.1    Dayyani, F.2    Gallick, G.E.3
  • 93
    • 33644976839 scopus 로고    scopus 로고
    • Regulation of SDF-1 (CXCL12) production by osteoblasts; A possible mechanism for stem cell homing
    • 16337237 1:CAS:528:DC%2BD28Xis1SqsLc%3D 10.1016/j.bone.2005.10.003
    • Jung Y, Wang J, Schneider A et al (2006) Regulation of SDF-1 (CXCL12) production by osteoblasts; a possible mechanism for stem cell homing. Bone 38:497-508
    • (2006) Bone , vol.38 , pp. 497-508
    • Jung, Y.1    Wang, J.2    Schneider, A.3
  • 94
    • 0037301981 scopus 로고    scopus 로고
    • Mechanisms of osteolytic bone metastases in breast carcinoma
    • 12548583 10.1002/cncr.11132
    • Kakonen SM, Mundy GR (2003) Mechanisms of osteolytic bone metastases in breast carcinoma. Cancer 97:834-839
    • (2003) Cancer , vol.97 , pp. 834-839
    • Kakonen, S.M.1    Mundy, G.R.2
  • 95
    • 0343416980 scopus 로고    scopus 로고
    • Endothelin-1 is a potent regulator of human bone cell metabolism in vitro
    • 9075635 1:CAS:528:DyaK2sXitFOjsLc%3D 10.1007/s002239900245
    • Kasperk CH, Borcsok I, Schairer HU et al (1997) Endothelin-1 is a potent regulator of human bone cell metabolism in vitro. Calcif Tissue Int 60:368-374
    • (1997) Calcif Tissue Int , vol.60 , pp. 368-374
    • Kasperk, C.H.1    Borcsok, I.2    Schairer, H.U.3
  • 96
    • 35649005989 scopus 로고    scopus 로고
    • Tumor-evoked hyperalgesia and sensitization of nociceptive dorsal horn neurons in a murine model of cancer pain
    • 17935703 1:CAS:528:DC%2BD2sXht1Grs7fI 10.1016/j.brainres.2007.08.075
    • Khasabov SG, Hamamoto DT, Harding-Rose C et al (2007) Tumor-evoked hyperalgesia and sensitization of nociceptive dorsal horn neurons in a murine model of cancer pain. Brain Res 1180:7-19
    • (2007) Brain Res , vol.1180 , pp. 7-19
    • Khasabov, S.G.1    Hamamoto, D.T.2    Harding-Rose, C.3
  • 97
    • 63449104335 scopus 로고    scopus 로고
    • Profiling of dynamically changed gene expression in dorsal root ganglia post peripheral nerve injury and a critical role of injury-induced glial fibrillary acidic protein in maintenance of pain behaviors
    • 19307059 1:CAS:528:DC%2BD1MXktV2msr0%3D 10.1016/j.pain.2009.02.006
    • Kim DS, Figueroa KW, Li KW et al (2009a) Profiling of dynamically changed gene expression in dorsal root ganglia post peripheral nerve injury and a critical role of injury-induced glial fibrillary acidic protein in maintenance of pain behaviors. Pain 143:114-122
    • (2009) Pain , vol.143 , pp. 114-122
    • Kim, D.S.1    Figueroa, K.W.2    Li, K.W.3
  • 98
    • 70349758510 scopus 로고    scopus 로고
    • Src kinases as therapeutic targets for cancer
    • 19787002 10.1038/nrclinonc.2009.129 1:CAS:528:DC%2BD1MXhtFyntbbP
    • Kim LC, Song L, Haura EB (2009b) Src kinases as therapeutic targets for cancer. Nat Rev Clin Oncol 6:587-595
    • (2009) Nat Rev Clin Oncol , vol.6 , pp. 587-595
    • Kim, L.C.1    Song, L.2    Haura, E.B.3
  • 99
    • 35848970582 scopus 로고    scopus 로고
    • Molecular biology of bone metastasis
    • 17938257 1:CAS:528:DC%2BD2sXhtFKltbnE 10.1158/1535-7163.MCT-07-0234
    • Kingsley LA, Fournier PG, Chirgwin JM et al (2007) Molecular biology of bone metastasis. Mol Cancer Ther 6:2609-2617
    • (2007) Mol Cancer Ther , vol.6 , pp. 2609-2617
    • Kingsley, L.A.1    Fournier, P.G.2    Chirgwin, J.M.3
  • 100
    • 0028200873 scopus 로고
    • Differential expression of extracellular matrix molecules and the alpha 6-integrins in the normal and neoplastic prostate
    • 8030747 1:STN:280:DyaK2czgtlOrug%3D%3D
    • Knox JD, Cress AE, Clark V et al (1994) Differential expression of extracellular matrix molecules and the alpha 6-integrins in the normal and neoplastic prostate. Am J Pathol 145:167-174
    • (1994) Am J Pathol , vol.145 , pp. 167-174
    • Knox, J.D.1    Cress, A.E.2    Clark, V.3
  • 101
    • 0037386202 scopus 로고    scopus 로고
    • Peripheral nerve injury alters excitatory synaptic transmission in lamina II of the rat dorsal horn
    • 12576493 1:CAS:528:DC%2BD3sXjsVKisrs%3D 10.1113/jphysiol.2002.036186
    • Kohno T, Moore KA, Baba H et al (2003) Peripheral nerve injury alters excitatory synaptic transmission in lamina II of the rat dorsal horn. J Physiol 548:131-138
    • (2003) J Physiol , vol.548 , pp. 131-138
    • Kohno, T.1    Moore, K.A.2    Baba, H.3
  • 102
    • 79959244402 scopus 로고    scopus 로고
    • Intravenous injection of leconotide, an omega conotoxin: Synergistic antihyperalgesic effects with morphine in a rat model of bone cancer pain
    • 21539704 10.1111/j.1526-4637.2011.01118.x
    • Kolosov A, Aurini L, Williams ED et al (2011) Intravenous injection of leconotide, an omega conotoxin: synergistic antihyperalgesic effects with morphine in a rat model of bone cancer pain. Pain Med 12:923-941
    • (2011) Pain Med , vol.12 , pp. 923-941
    • Kolosov, A.1    Aurini, L.2    Williams, E.D.3
  • 103
    • 67650601930 scopus 로고    scopus 로고
    • Dasatinib inhibits the growth of prostate cancer in bone and provides additional protection from osteolysis
    • 19603032 1:CAS:528:DC%2BD1MXoslOmtLc%3D 10.1038/sj.bjc.6605178
    • Koreckij T, Nguyen H, Brown LG et al (2009) Dasatinib inhibits the growth of prostate cancer in bone and provides additional protection from osteolysis. Br J Cancer 101:263-268
    • (2009) Br J Cancer , vol.101 , pp. 263-268
    • Koreckij, T.1    Nguyen, H.2    Brown, L.G.3
  • 104
    • 22744455581 scopus 로고    scopus 로고
    • Breast cancer metastasis to bone: Mechanisms of osteolysis and implications for therapy
    • 16025223 10.1007/s10911-005-5399-8
    • Kozlow W, Guise TA (2005) Breast cancer metastasis to bone: mechanisms of osteolysis and implications for therapy. J Mammary Gland Biol Neoplasia 10:169-180
    • (2005) J Mammary Gland Biol Neoplasia , vol.10 , pp. 169-180
    • Kozlow, W.1    Guise, T.A.2
  • 105
    • 0034937386 scopus 로고    scopus 로고
    • Nerve growth factor inhibition prevents traumatic neuroma formation in the rat
    • 11466637 1:STN:280:DC%2BD3Mvis1OrsA%3D%3D 10.1053/jhsu.2001.26035
    • Kryger GS, Kryger Z, Zhang F et al (2001) Nerve growth factor inhibition prevents traumatic neuroma formation in the rat. J Hand Surg Am 26:635-644
    • (2001) J Hand Surg Am , vol.26 , pp. 635-644
    • Kryger, G.S.1    Kryger, Z.2    Zhang, F.3
  • 106
    • 0035452412 scopus 로고    scopus 로고
    • Increased cyclooxygenase-2 (cox-2) expression and activity in a murine model of metastatic breast cancer
    • 11477578 1:CAS:528:DC%2BD3MXls1Wgtrk%3D 10.1002/ijc.1397
    • Kundu N, Yang Q, Dorsey R et al (2001) Increased cyclooxygenase-2 (cox-2) expression and activity in a murine model of metastatic breast cancer. Int J Cancer 93:681-686
    • (2001) Int J Cancer , vol.93 , pp. 681-686
    • Kundu, N.1    Yang, Q.2    Dorsey, R.3
  • 107
    • 1642432081 scopus 로고    scopus 로고
    • IL-6, RANKL, TNF-alpha/IL-1: Interrelations in bone resorption pathophysiology
    • 14746813 10.1016/j.cytogfr.2003.10.005 1:CAS:528:DC%2BD2cXmvFKktA%3D%3D
    • Kwan Tat S, Padrines M, Theoleyre S et al (2004) IL-6, RANKL, TNF-alpha/IL-1: interrelations in bone resorption pathophysiology. Cytokine Growth Factor Rev 15:49-60
    • (2004) Cytokine Growth Factor Rev , vol.15 , pp. 49-60
    • Kwan Tat, S.1    Padrines, M.2    Theoleyre, S.3
  • 108
    • 0032540319 scopus 로고    scopus 로고
    • Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation
    • 9568710 1:CAS:528:DyaK1cXivVyhtrg%3D 10.1016/S0092-8674(00)81569-X
    • Lacey DL, Timms E, Tan HL et al (1998) Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation. Cell 93:165-176
    • (1998) Cell , vol.93 , pp. 165-176
    • Lacey, D.L.1    Timms, E.2    Tan, H.L.3
  • 109
    • 0027238585 scopus 로고
    • An electrophysiological study of dorsal horn neurons in the spinal cord of rats with an experimental peripheral neuropathy
    • 8394412 1:STN:280:DyaK3szltlansA%3D%3D
    • Laird JM, Bennett GJ (1993) An electrophysiological study of dorsal horn neurons in the spinal cord of rats with an experimental peripheral neuropathy. J Neurophysiol 69:2072-2085
    • (1993) J Neurophysiol , vol.69 , pp. 2072-2085
    • Laird, J.M.1    Bennett, G.J.2
  • 110
    • 36849008609 scopus 로고    scopus 로고
    • Endothelin receptor antagonists in cancer therapy
    • 18058475 1:CAS:528:DC%2BD2sXhtl2isrvL 10.1080/07357900701522588
    • Lalich M, McNeel DG, Wilding G et al (2007) Endothelin receptor antagonists in cancer therapy. Cancer Invest 25:785-794
    • (2007) Cancer Invest , vol.25 , pp. 785-794
    • Lalich, M.1    McNeel, D.G.2    Wilding, G.3
  • 111
    • 40949146185 scopus 로고    scopus 로고
    • Combined use of zoledronic acid and 153Sm-EDTMP in hormone-refractory prostate cancer patients with bone metastases
    • 18157530 1:CAS:528:DC%2BD1cXjsVCksr4%3D 10.1007/s00259-007-0659-z
    • Lam MG, Dahmane A, Stevens WHBA et al (2008) Combined use of zoledronic acid and 153Sm-EDTMP in hormone-refractory prostate cancer patients with bone metastases. Eur J Nucl Med Mol Imaging 35:756-765
    • (2008) Eur J Nucl Med Mol Imaging , vol.35 , pp. 756-765
    • Lam, M.G.1    Dahmane, A.2    Stevens, W.3
  • 112
    • 33646697521 scopus 로고    scopus 로고
    • Clinical applications of 188Re-labelled radiopharmaceuticals for radionuclide therapy
    • 16479241 1:CAS:528:DC%2BD28XhsVKrs70%3D 10.1097/00006231-200603000-00004
    • Lambert B, de Klerk JM (2006) Clinical applications of 188Re-labelled radiopharmaceuticals for radionuclide therapy. Nucl Med Commun 27:223-229
    • (2006) Nucl Med Commun , vol.27 , pp. 223-229
    • Lambert, B.1    De Klerk, J.M.2
  • 113
    • 38349051944 scopus 로고    scopus 로고
    • Relevance of a new rat model of osteoblastic metastases from prostate carcinoma for preclinical studies using zoledronic acid
    • 17960623 1:CAS:528:DC%2BD1cXhsFShsrs%3D 10.1002/ijc.23187
    • Lamoureux F, Ory B, Battaglia S et al (2008) Relevance of a new rat model of osteoblastic metastases from prostate carcinoma for preclinical studies using zoledronic acid. Int J Cancer 122:751-760
    • (2008) Int J Cancer , vol.122 , pp. 751-760
    • Lamoureux, F.1    Ory, B.2    Battaglia, S.3
  • 114
    • 61749096864 scopus 로고    scopus 로고
    • A phase II trial of the Src-kinase inhibitor AZD0530 in patients with advanced castration-resistant prostate cancer: A California Cancer Consortium study
    • 19396016 1:CAS:528:DC%2BD1MXjtl2ntL0%3D 10.1097/CAD.0b013e328325a867
    • Lara PN Jr, Longmate J, Evans CP et al (2009) A phase II trial of the Src-kinase inhibitor AZD0530 in patients with advanced castration-resistant prostate cancer: a California Cancer Consortium study. Anticancer Drugs 20:179-184
    • (2009) Anticancer Drugs , vol.20 , pp. 179-184
    • Lara, Jr.P.N.1    Longmate, J.2    Evans, C.P.3
  • 115
    • 68949189686 scopus 로고    scopus 로고
    • Central sensitization: A generator of pain hypersensitivity by central neural plasticity
    • 19712899 10.1016/j.jpain.2009.06.012
    • Latremoliere A, Woolf CJ (2009) Central sensitization: a generator of pain hypersensitivity by central neural plasticity. J Pain 10:895-926
    • (2009) J Pain , vol.10 , pp. 895-926
    • Latremoliere, A.1    Woolf, C.J.2
  • 116
    • 0035204477 scopus 로고    scopus 로고
    • Neuropeptide-induced androgen independence in prostate cancer cells: Roles of nonreceptor tyrosine kinases Etk/Bmx, Src, and focal adhesion kinase
    • 11713275 1:CAS:528:DC%2BD3MXovVegsLk%3D 10.1128/MCB.21.24.8385-8397.2001
    • Lee LF, Guan J, Qiu Y et al (2001) Neuropeptide-induced androgen independence in prostate cancer cells: roles of nonreceptor tyrosine kinases Etk/Bmx, Src, and focal adhesion kinase. Mol Cell Biol 21:8385-8397
    • (2001) Mol Cell Biol , vol.21 , pp. 8385-8397
    • Lee, L.F.1    Guan, J.2    Qiu, Y.3
  • 117
    • 1842434391 scopus 로고    scopus 로고
    • Interleukin-8 confers androgen-independent growth and migration of LNCaP: Differential effects of tyrosine kinases Src and FAK
    • 14767470 1:CAS:528:DC%2BD2cXitFCmtr4%3D 10.1038/sj.onc.1207344
    • Lee LF, Louie MC, Desai SJ et al (2004) Interleukin-8 confers androgen-independent growth and migration of LNCaP: differential effects of tyrosine kinases Src and FAK. Oncogene 23:2197-2205
    • (2004) Oncogene , vol.23 , pp. 2197-2205
    • Lee, L.F.1    Louie, M.C.2    Desai, S.J.3
  • 118
    • 78650305379 scopus 로고    scopus 로고
    • Treatment and prevention of bone complications from prostate cancer
    • 20621630 1:CAS:528:DC%2BC3cXhs1Wgu7vN 10.1016/j.bone.2010.05.038
    • Lee RJ, Saylor PJ, Smith MR (2011) Treatment and prevention of bone complications from prostate cancer. Bone 48:88-95
    • (2011) Bone , vol.48 , pp. 88-95
    • Lee, R.J.1    Saylor, P.J.2    Smith, M.R.3
  • 119
    • 52649094391 scopus 로고    scopus 로고
    • Biochemical markers for monitoring response to therapy: Evidence for higher bone specificity by a novel marker compared with routine markers
    • 18483350 1:CAS:528:DC%2BD1cXmtVCltr0%3D 10.1158/1055-9965.EPI-07-2697
    • Leeming DJ, Hegele A, Byrjalsen I et al (2008) Biochemical markers for monitoring response to therapy: evidence for higher bone specificity by a novel marker compared with routine markers. Cancer Epidemiol Biomarkers Prev 17:1269-1276
    • (2008) Cancer Epidemiol Biomarkers Prev , vol.17 , pp. 1269-1276
    • Leeming, D.J.1    Hegele, A.2    Byrjalsen, I.3
  • 120
    • 84901979300 scopus 로고    scopus 로고
    • New considerations in the design of clinical trials for bone metastases
    • 10.5306/wjco.v3.i1.1
    • Lemke M, Liena K, Zenga L et al (2012) New considerations in the design of clinical trials for bone metastases. World J Oncol 3:1-7
    • (2012) World J Oncol , vol.3 , pp. 1-7
    • Lemke, M.1    Liena, K.2    Zenga, L.3
  • 121
    • 78650074746 scopus 로고    scopus 로고
    • Sclerostin monoclonal antibody therapy with AMG 785: A potential treatment for osteoporosis
    • 21114421 1:CAS:528:DC%2BC3cXhsFalsrnE 10.1517/14712598.2011.540565
    • Lewiecki EM (2011) Sclerostin monoclonal antibody therapy with AMG 785: a potential treatment for osteoporosis. Expert Opin Biol Ther 11:117-127
    • (2011) Expert Opin Biol Ther , vol.11 , pp. 117-127
    • Lewiecki, E.M.1
  • 122
    • 0029763967 scopus 로고    scopus 로고
    • Cancer therapy using bone-seeking isotopes
    • 8912378 1:CAS:528:DyaK28XmsVOitL0%3D 10.1088/0031-9155/41/10/012
    • Lewington VJ (1996) Cancer therapy using bone-seeking isotopes. Phys Med Biol 41:2027-2042
    • (1996) Phys Med Biol , vol.41 , pp. 2027-2042
    • Lewington, V.J.1
  • 123
    • 0025781809 scopus 로고
    • A prospective, randomised double-blind crossover study to examine the efficacy of strontium-89 in pain palliation in patients with advanced prostate cancer metastatic to bone
    • 1716935 1:STN:280:DyaK38%2FgtVyrsw%3D%3D 10.1016/0277-5379(91)90257-E
    • Lewington VJ, McEwan AJ, Ackery DM et al (1991) A prospective, randomised double-blind crossover study to examine the efficacy of strontium-89 in pain palliation in patients with advanced prostate cancer metastatic to bone. Eur J Cancer 27:954-958
    • (1991) Eur J Cancer , vol.27 , pp. 954-958
    • Lewington, V.J.1    McEwan, A.J.2    Ackery, D.M.3
  • 124
    • 12944262423 scopus 로고    scopus 로고
    • RANK is the intrinsic hematopoietic cell surface receptor that controls osteoclastogenesis and regulation of bone mass and calcium metabolism
    • 10677500 1:CAS:528:DC%2BD3cXhsFCrsL4%3D 10.1073/pnas.97.4.1566
    • Li J, Sarosi I, Yan XQ et al (2000) RANK is the intrinsic hematopoietic cell surface receptor that controls osteoclastogenesis and regulation of bone mass and calcium metabolism. Proc Natl Acad Sci USA 97:1566-1571
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 1566-1571
    • Li, J.1    Sarosi, I.2    Yan, X.Q.3
  • 125
    • 44449099165 scopus 로고    scopus 로고
    • Targeted deletion of the sclerostin gene in mice results in increased bone formation and bone strength
    • 18269310 10.1359/jbmr.080216
    • Li X, Ominsky MS, Niu QT et al (2008) Targeted deletion of the sclerostin gene in mice results in increased bone formation and bone strength. J Bone Miner Res 23:860-869
    • (2008) J Bone Miner Res , vol.23 , pp. 860-869
    • Li, X.1    Ominsky, M.S.2    Niu, Q.T.3
  • 126
    • 65549152230 scopus 로고    scopus 로고
    • Sclerostin antibody treatment increases bone formation, bone mass, and bone strength in a rat model of postmenopausal osteoporosis
    • 19049336 1:CAS:528:DC%2BD1MXksF2lu7c%3D 10.1359/jbmr.081206
    • Li X, Ominsky MS, Warmington KS et al (2009) Sclerostin antibody treatment increases bone formation, bone mass, and bone strength in a rat model of postmenopausal osteoporosis. J Bone Miner Res 24:578-588
    • (2009) J Bone Miner Res , vol.24 , pp. 578-588
    • Li, X.1    Ominsky, M.S.2    Warmington, K.S.3
  • 127
    • 34447545672 scopus 로고    scopus 로고
    • A comparative study of 188Re-HEDP, 186Re-HEDP, 153Sm-EDTMP and 89Sr in the treatment of painful skeletal metastases
    • 17625384 1:CAS:528:DC%2BD2sXnsFOjt7k%3D 10.1097/MNM.0b013e32825a6adc
    • Liepe K, Kotzerke J (2007) A comparative study of 188Re-HEDP, 186Re-HEDP, 153Sm-EDTMP and 89Sr in the treatment of painful skeletal metastases. Nucl Med Commun 28:623-630
    • (2007) Nucl Med Commun , vol.28 , pp. 623-630
    • Liepe, K.1    Kotzerke, J.2
  • 128
    • 17444419735 scopus 로고    scopus 로고
    • New model for the induction of osteoblastic bone metastases in rat
    • 15868947 1:STN:280:DC%2BD2M3jsVeksw%3D%3D
    • Liepe K, Geidel H, Haase M et al (2005) New model for the induction of osteoblastic bone metastases in rat. Anticancer Res 25:1067-1073
    • (2005) Anticancer Res , vol.25 , pp. 1067-1073
    • Liepe, K.1    Geidel, H.2    Haase, M.3
  • 129
    • 33846669522 scopus 로고    scopus 로고
    • Use of bisphosphonates in advanced prostate cancer: Current status
    • 19675764 10.4103/0970-1591.30268
    • Lilleby W (2007) Use of bisphosphonates in advanced prostate cancer: current status. Indian J Urol 23:54
    • (2007) Indian J Urol , vol.23 , pp. 54
    • Lilleby, W.1
  • 130
    • 33846034920 scopus 로고    scopus 로고
    • Targeted and systemic radiotherapy in the treatment of bone metastasis
    • 17160556 10.1007/s10555-006-9025-z
    • Lin A, Ray ME (2006) Targeted and systemic radiotherapy in the treatment of bone metastasis. Cancer Metastasis Rev 25:669-675
    • (2006) Cancer Metastasis Rev , vol.25 , pp. 669-675
    • Lin, A.1    Ray, M.E.2
  • 131
    • 36749079838 scopus 로고    scopus 로고
    • Dissociation of spinal microglia morphological activation and peripheral inflammation in inflammatory pain models
    • 17919739 1:CAS:528:DC%2BD2sXhsVSlsr7N 10.1016/j.jneuroim.2007.09.003
    • Lin T, Li K, Zhang FY et al (2007) Dissociation of spinal microglia morphological activation and peripheral inflammation in inflammatory pain models. J Neuroimmunol 192:40-48
    • (2007) J Neuroimmunol , vol.192 , pp. 40-48
    • Lin, T.1    Li, K.2    Zhang, F.Y.3
  • 132
    • 70349934212 scopus 로고    scopus 로고
    • Sclerostin mediates bone response to mechanical unloading through antagonizing Wnt/beta-catenin signaling
    • 19419300 1:CAS:528:DC%2BD1MXhtlGgurbF 10.1359/jbmr.090411
    • Lin C, Jiang X, Dai Z et al (2009) Sclerostin mediates bone response to mechanical unloading through antagonizing Wnt/beta-catenin signaling. J Bone Miner Res 24:1651-1661
    • (2009) J Bone Miner Res , vol.24 , pp. 1651-1661
    • Lin, C.1    Jiang, X.2    Dai, Z.3
  • 133
    • 33947168356 scopus 로고    scopus 로고
    • Treatment of bone metastases and bone pain with bisphosphonates
    • 18632473 1:CAS:528:DC%2BD2sXktFKqtLo%3D 10.3816/SCT.2007.n.003
    • Lipton A (2007) Treatment of bone metastases and bone pain with bisphosphonates. Support Cancer Ther 4:92-100
    • (2007) Support Cancer Ther , vol.4 , pp. 92-100
    • Lipton, A.1
  • 134
    • 77953342702 scopus 로고    scopus 로고
    • Bone continuum of cancer
    • 20526089 1:CAS:528:DC%2BC3cXntVSktLY%3D 10.1097/COC.0b013e3181deb9e5
    • Lipton A (2010) Bone continuum of cancer. Am J Clin Oncol 33:S1-S7
    • (2010) Am J Clin Oncol , vol.33
    • Lipton, A.1
  • 135
    • 78650397541 scopus 로고    scopus 로고
    • Clinical development of anti-RANKL therapies for treatment and prevention of bone metastasis
    • 20950721 1:CAS:528:DC%2BC3cXhs1Wgu7vI 10.1016/j.bone.2010.10.161
    • Lipton A, Goessl C (2011) Clinical development of anti-RANKL therapies for treatment and prevention of bone metastasis. Bone 48:96-99
    • (2011) Bone , vol.48 , pp. 96-99
    • Lipton, A.1    Goessl, C.2
  • 136
    • 15144356711 scopus 로고    scopus 로고
    • The osteoclast-associated protease cathepsin K is expressed in human breast carcinoma
    • 9393764 1:CAS:528:DyaK2sXnslGqsrY%3D
    • Littlewood-Evans AJ, Bilbe G, Bowler WB et al (1997) The osteoclast-associated protease cathepsin K is expressed in human breast carcinoma. Cancer Res 57:5386-5390
    • (1997) Cancer Res , vol.57 , pp. 5386-5390
    • Littlewood-Evans, A.J.1    Bilbe, G.2    Bowler, W.B.3
  • 137
    • 79952551635 scopus 로고    scopus 로고
    • Electrophysiological properties of spinal wide dynamic range neurons in neuropathic pain rats following spinal nerve ligation
    • 21270898 10.1007/s12264-011-1039-z
    • Liu FY, Qu XX, Cai J et al (2011) Electrophysiological properties of spinal wide dynamic range neurons in neuropathic pain rats following spinal nerve ligation. Neurosci Bull 27:1-8
    • (2011) Neurosci Bull , vol.27 , pp. 1-8
    • Liu, F.Y.1    Qu, X.X.2    Cai, J.3
  • 138
    • 60449090099 scopus 로고    scopus 로고
    • Activation of MCP-1/CCR2 axis promotes prostate cancer growth in bone
    • 19002595 10.1007/s10585-008-9226-7 1:CAS:528:DC%2BD1MXhvVKqtbs%3D
    • Lu Y, Chen Q, Corey E et al (2009) Activation of MCP-1/CCR2 axis promotes prostate cancer growth in bone. Clin Exp Metastasis 26:161-169
    • (2009) Clin Exp Metastasis , vol.26 , pp. 161-169
    • Lu, Y.1    Chen, Q.2    Corey, E.3
  • 139
    • 34848911983 scopus 로고    scopus 로고
    • Establishment of bone metastasis model of prostate cancer in nude mice by intratibia injection of human prostate cancer cell line Du145
    • 16519149
    • Luo Y, Zhang LL, Ning L et al (2006) Establishment of bone metastasis model of prostate cancer in nude mice by intratibia injection of human prostate cancer cell line Du145. Zhonghua Nan Ke Xue 12:133-136
    • (2006) Zhonghua Nan Ke Xue , vol.12 , pp. 133-136
    • Luo, Y.1    Zhang, L.L.2    Ning, L.3
  • 140
    • 0031655802 scopus 로고    scopus 로고
    • Multistep nature of metastatic inefficiency: Dormancy of solitary cells after successful extravasation and limited survival of early micrometastases
    • 9736035 1:STN:280:DyaK1cvgsFCnsA%3D%3D 10.1016/S0002-9440(10)65628-3
    • Luzzi KJ, MacDonald IC, Schmidt EE et al (1998) Multistep nature of metastatic inefficiency: dormancy of solitary cells after successful extravasation and limited survival of early micrometastases. Am J Pathol 153:865-873
    • (1998) Am J Pathol , vol.153 , pp. 865-873
    • Luzzi, K.J.1    Macdonald, I.C.2    Schmidt, E.E.3
  • 141
    • 56149089509 scopus 로고    scopus 로고
    • Randomised study of single dose (8 Gy vs. 6 Gy) of analgesic radiotherapy plus zoledronic acid in patients with bone metastases
    • 18490245 1:CAS:528:DC%2BD1cXovV2ru7c%3D 10.1007/s12094-008-0198-5
    • Manas A, Casas F, Ciria JP et al (2008) Randomised study of single dose (8 Gy vs. 6 Gy) of analgesic radiotherapy plus zoledronic acid in patients with bone metastases. Clin Transl Oncol 10:281-287
    • (2008) Clin Transl Oncol , vol.10 , pp. 281-287
    • Manas, A.1    Casas, F.2    Ciria, J.P.3
  • 142
    • 33748934201 scopus 로고    scopus 로고
    • Cancer pain and its impact on diagnosis, survival and quality of life
    • 16988655 1:CAS:528:DC%2BD28Xpslamurg%3D 10.1038/nrn1914
    • Mantyh PW (2006) Cancer pain and its impact on diagnosis, survival and quality of life. Nat Rev Neurosci 7:797-809
    • (2006) Nat Rev Neurosci , vol.7 , pp. 797-809
    • Mantyh, P.W.1
  • 143
    • 79959509581 scopus 로고    scopus 로고
    • Antagonism of nerve growth factor-TrkA signaling and the relief of pain
    • 21602663 10.1097/ALN.0b013e31821b1ac5
    • Mantyh PW, Koltzenburg M, Mendell LM et al (2011) Antagonism of nerve growth factor-TrkA signaling and the relief of pain. Anesthesiology 115:189-204
    • (2011) Anesthesiology , vol.115 , pp. 189-204
    • Mantyh, P.W.1    Koltzenburg, M.2    Mendell, L.M.3
  • 144
    • 79961118892 scopus 로고    scopus 로고
    • Sclerostin antibody treatment enhances bone strength but does not prevent growth retardation in young mice treated with dexamethasone
    • 21484764 1:CAS:528:DC%2BC3MXpsFejsbk%3D 10.1002/art.30385
    • Marenzana M, Greenslade K, Eddleston A et al (2011) Sclerostin antibody treatment enhances bone strength but does not prevent growth retardation in young mice treated with dexamethasone. Arthritis Rheum 63:2385-2395
    • (2011) Arthritis Rheum , vol.63 , pp. 2385-2395
    • Marenzana, M.1    Greenslade, K.2    Eddleston, A.3
  • 145
    • 31544440149 scopus 로고    scopus 로고
    • Phosphorylation sites on calcium channel alpha1 and beta subunits regulate ERK-dependent modulation of neuronal N-type calcium channels
    • 16406008 1:CAS:528:DC%2BD28XhtVansbs%3D 10.1016/j.ceca.2005.11.002
    • Martin SW, Butcher AJ, Berrow NS et al (2006) Phosphorylation sites on calcium channel alpha1 and beta subunits regulate ERK-dependent modulation of neuronal N-type calcium channels. Cell Calcium 39:275-292
    • (2006) Cell Calcium , vol.39 , pp. 275-292
    • Martin, S.W.1    Butcher, A.J.2    Berrow, N.S.3
  • 146
    • 35448929372 scopus 로고    scopus 로고
    • Organization of a unique net-like meshwork of CGRP + sensory fibers in the mouse periosteum: Implications for the generation and maintenance of bone fracture pain
    • 17950532 1:CAS:528:DC%2BD2sXht1Kjsb3L 10.1016/j.neulet.2007.08.055
    • Martin CD, Jimenez-Andrade JM, Ghilardi JR et al (2007) Organization of a unique net-like meshwork of CGRP + sensory fibers in the mouse periosteum: implications for the generation and maintenance of bone fracture pain. Neurosci Lett 427:148-152
    • (2007) Neurosci Lett , vol.427 , pp. 148-152
    • Martin, C.D.1    Jimenez-Andrade, J.M.2    Ghilardi, J.R.3
  • 147
    • 18944385512 scopus 로고    scopus 로고
    • NSAIDS or paracetamol, alone or combined with opioids, for cancer pain
    • McNicol E, Strassels SA, Goudas L et al (2005) NSAIDS or paracetamol, alone or combined with opioids, for cancer pain. Cochrane Database Syst Rev 25:CD005180
    • (2005) Cochrane Database Syst Rev , vol.25
    • McNicol, E.1    Strassels, S.A.2    Goudas, L.3
  • 149
    • 0031056437 scopus 로고    scopus 로고
    • Malignant bone pain: Pathophysiology and treatment
    • 9060007 1:STN:280:DyaK2s3htlansA%3D%3D 10.1016/S0304-3959(96)03267-8
    • Mercadante S (1997) Malignant bone pain: pathophysiology and treatment. Pain 69:1-18
    • (1997) Pain , vol.69 , pp. 1-18
    • Mercadante, S.1
  • 150
    • 0032454825 scopus 로고    scopus 로고
    • Breakthrough pain in cancer patients: Pathophysiology and treatment
    • 10189409 1:STN:280:DyaK1M3gsFCjtQ%3D%3D 10.1016/S0305-7372(98)90005-6
    • Mercadante S, Arcuri E (1998) Breakthrough pain in cancer patients: pathophysiology and treatment. Cancer Treat Rev 24:425-432
    • (1998) Cancer Treat Rev , vol.24 , pp. 425-432
    • Mercadante, S.1    Arcuri, E.2
  • 151
    • 34250009724 scopus 로고    scopus 로고
    • Management of painful bone metastases
    • 17545792 10.1097/CCO.0b013e3281214400
    • Mercadante S, Fulfaro F (2007) Management of painful bone metastases. Curr Opin Oncol 19:308-314
    • (2007) Curr Opin Oncol , vol.19 , pp. 308-314
    • Mercadante, S.1    Fulfaro, F.2
  • 153
    • 79952118262 scopus 로고    scopus 로고
    • Sclerostin: Current knowledge and future perspectives
    • 20473488 1:CAS:528:DC%2BC3cXoslals7s%3D 10.1007/s00223-010-9372-1
    • Moester MJ, Papapoulos SE, Lowik CW et al (2010) Sclerostin: current knowledge and future perspectives. Calcif Tissue Int 87:99-107
    • (2010) Calcif Tissue Int , vol.87 , pp. 99-107
    • Moester, M.J.1    Papapoulos, S.E.2    Lowik, C.W.3
  • 154
    • 0142157085 scopus 로고    scopus 로고
    • Mechanisms of osteoblastic metastases: Role of endothelin-1
    • 14600594 10.1097/01.blo.0000093047.96273.4e
    • Mohammad KS, Guise TA (2003) Mechanisms of osteoblastic metastases: role of endothelin-1. Clin Orthop Relat Res 415:S67-S74
    • (2003) Clin Orthop Relat Res , vol.415
    • Mohammad, K.S.1    Guise, T.A.2
  • 155
    • 34447264104 scopus 로고    scopus 로고
    • The role of tumor microenvironment in prostate cancer bone metastasis
    • 17387734 1:CAS:528:DC%2BD2sXnvVSqu7Y%3D 10.1002/jcb.21214
    • Morrissey C, Vessella RL (2007) The role of tumor microenvironment in prostate cancer bone metastasis. J Cell Biochem 101:873-886
    • (2007) J Cell Biochem , vol.101 , pp. 873-886
    • Morrissey, C.1    Vessella, R.L.2
  • 156
    • 42949179038 scopus 로고    scopus 로고
    • Mechanisms of bone metastasis in prostate cancer: Clinical implications
    • 18471791 1:CAS:528:DC%2BD1cXlslygtrk%3D 10.1016/j.beem.2008.01.011
    • Msaouel P, Pissimissis N, Halapas A et al (2008) Mechanisms of bone metastasis in prostate cancer: clinical implications. Best Pract Res Clin Endocrinol Metab 22:341-355
    • (2008) Best Pract Res Clin Endocrinol Metab , vol.22 , pp. 341-355
    • Msaouel, P.1    Pissimissis, N.2    Halapas, A.3
  • 157
    • 0035237074 scopus 로고    scopus 로고
    • Growth regulatory factors and bone
    • 11704973 1:CAS:528:DC%2BD3MXht1Wjt74%3D 10.1023/A:1010015309973
    • Mundy GR, Chen D, Zhao M et al (2001) Growth regulatory factors and bone. Rev Endocr Metab Disord 2:105-115
    • (2001) Rev Endocr Metab Disord , vol.2 , pp. 105-115
    • Mundy, G.R.1    Chen, D.2    Zhao, M.3
  • 158
    • 84875986982 scopus 로고    scopus 로고
    • Optimization and characterization of a rat model of prostate cancer-induced bone pain using behavioural, pharmacological, radiological, histological and immunohistochemical methods
    • 23500189 1:CAS:528:DC%2BC3sXpslGhsr0%3D 10.1016/j.pbb.2013.02.020
    • Muralidharan A, Wyse BD, Smith MT (2013) Optimization and characterization of a rat model of prostate cancer-induced bone pain using behavioural, pharmacological, radiological, histological and immunohistochemical methods. Pharmacol Biochem Behav 106:33-46
    • (2013) Pharmacol Biochem Behav , vol.106 , pp. 33-46
    • Muralidharan, A.1    Wyse, B.D.2    Smith, M.T.3
  • 159
    • 84880919122 scopus 로고    scopus 로고
    • A phase i trial of KX2-391, a novel non-ATP competitive substrate-pocket- directed SRC inhibitor, in patients with advanced malignancies
    • 10.1007/s10637-013-9929-8
    • Naing A, Cohen R, Dy GK et al (2013) A phase I trial of KX2-391, a novel non-ATP competitive substrate-pocket- directed SRC inhibitor, in patients with advanced malignancies. Invest New Drugs. doi: 10.1007/s10637-013-9929-8
    • (2013) Invest New Drugs
    • Naing, A.1    Cohen, R.2    Dy, G.K.3
  • 160
    • 35948935128 scopus 로고    scopus 로고
    • Involvement of alpha(v)beta3 integrins in osteoclast function
    • 17968485 1:CAS:528:DC%2BD2sXht1aqtLrM 10.1007/s00774-007-0773-9
    • Nakamura I, le Duong T, Rodan SB et al (2007) Involvement of alpha(v)beta3 integrins in osteoclast function. J Bone Miner Metab 25:337-344
    • (2007) J Bone Miner Metab , vol.25 , pp. 337-344
    • Nakamura, I.1    Le Duong, T.2    Rodan, S.B.3
  • 161
    • 27144547509 scopus 로고    scopus 로고
    • Action of the Src family kinase inhibitor, dasatinib (BMS-354825), on human prostate cancer cells
    • 16230377 1:CAS:528:DC%2BD2MXhtFWmu77K 10.1158/0008-5472.CAN-05-1731
    • Nam S, Kim D, Cheng JQ et al (2005) Action of the Src family kinase inhibitor, dasatinib (BMS-354825), on human prostate cancer cells. Cancer Res 65:9185-9189
    • (2005) Cancer Res , vol.65 , pp. 9185-9189
    • Nam, S.1    Kim, D.2    Cheng, J.Q.3
  • 162
    • 0029085123 scopus 로고
    • Identification of endothelin-1 in the pathophysiology of metastatic adenocarcinoma of the prostate
    • 7585222 1:CAS:528:DyaK2MXnvVyrtb8%3D 10.1038/nm0995-944
    • Nelson JB, Hedican SP, George DJ et al (1995) Identification of endothelin-1 in the pathophysiology of metastatic adenocarcinoma of the prostate. Nat Med 1:944-949
    • (1995) Nat Med , vol.1 , pp. 944-949
    • Nelson, J.B.1    Hedican, S.P.2    George, D.J.3
  • 163
    • 0037364732 scopus 로고    scopus 로고
    • Suppression of prostate cancer induced bone remodeling by the endothelin receptor A antagonist atrasentan
    • 12576870 1:CAS:528:DC%2BD3sXht1Cms7c%3D 10.1097/01.ju.0000042162.08938.27
    • Nelson JB, Nabulsi AA, Vogelzang NJ et al (2003) Suppression of prostate cancer induced bone remodeling by the endothelin receptor A antagonist atrasentan. J Urol 169:1143-1149
    • (2003) J Urol , vol.169 , pp. 1143-1149
    • Nelson, J.B.1    Nabulsi, A.A.2    Vogelzang, N.J.3
  • 164
    • 55549112219 scopus 로고    scopus 로고
    • Phase 3, randomized, controlled trial of atrasentan in patients with nonmetastatic, hormone-refractory prostate cancer
    • 18785254 1:CAS:528:DC%2BD1cXhtlKru77K 10.1002/cncr.23864
    • Nelson JB, Love W, Chin JL, Saad F, Schulman CC, Sleep DJ, Qian J, Steinberg J, Carducci M (2008) Phase 3, randomized, controlled trial of atrasentan in patients with nonmetastatic, hormone-refractory prostate cancer. Cancer 113:2478-2487
    • (2008) Cancer , vol.113 , pp. 2478-2487
    • Nelson, J.B.1    Love, W.2    Chin, J.L.3    Saad, F.4    Schulman, C.C.5    Sleep, D.J.6    Qian, J.7    Steinberg, J.8    Carducci, M.9
  • 165
    • 34547658885 scopus 로고    scopus 로고
    • Current approach to cancer pain management: Availability and implications of different treatment options
    • 18488078 1:CAS:528:DC%2BD2sXps1CqsLY%3D
    • Nersesyan H, Slavin KV (2007) Current approach to cancer pain management: availability and implications of different treatment options. Ther Clin Risk Manag 3:381-400
    • (2007) Ther Clin Risk Manag , vol.3 , pp. 381-400
    • Nersesyan, H.1    Slavin, K.V.2
  • 166
    • 4043138669 scopus 로고    scopus 로고
    • Osteoprotegerin (OPG) produced by bone marrow stromal cells protects breast cancer cells from TRAIL-induced apoptosis
    • 15567943 1:CAS:528:DC%2BD2cXmt1Kqtro%3D 10.1023/B:BREA.0000036900.48763. b3
    • Neville-Webbe HL, Cross NA, Eaton CL et al (2004) Osteoprotegerin (OPG) produced by bone marrow stromal cells protects breast cancer cells from TRAIL-induced apoptosis. Breast Cancer Res Treat 86:269-279
    • (2004) Breast Cancer Res Treat , vol.86 , pp. 269-279
    • Neville-Webbe, H.L.1    Cross, N.A.2    Eaton, C.L.3
  • 167
    • 84858706749 scopus 로고    scopus 로고
    • A randomized, dose-response, multicenter phase II study of radium-223 chloride for the palliation of painful bone metastases in patients with castration-resistant prostate cancer
    • 22341993 1:CAS:528:DC%2BC38Xkt1Gmt78%3D 10.1016/j.ejca.2011.12.023
    • Nilsson S, Strang P, Aksnes AK et al (2012) A randomized, dose-response, multicenter phase II study of radium-223 chloride for the palliation of painful bone metastases in patients with castration-resistant prostate cancer. Eur J Cancer 48:678-686
    • (2012) Eur J Cancer , vol.48 , pp. 678-686
    • Nilsson, S.1    Strang, P.2    Aksnes, A.K.3
  • 168
    • 84886604050 scopus 로고    scopus 로고
    • Pain analysis from the phase III randomized ALSYMPCA study with radium-223 dichloride (Ra-223) in patients with castration-resistant prostate cancer (CRPC) with bone metastases
    • Nilsson S, Sartor O, Oyvind S et al (2013) Pain analysis from the phase III randomized ALSYMPCA study with radium-223 dichloride (Ra-223) in patients with castration-resistant prostate cancer (CRPC) with bone metastases. J Clin Oncol 31(Suppl 6):19
    • (2013) J Clin Oncol , vol.31 , Issue.SUPPL. 6 , pp. 19
    • Nilsson, S.1    Sartor, O.2    Oyvind, S.3
  • 169
    • 74049160907 scopus 로고    scopus 로고
    • Time course of pain relief in patients treated with radiotherapy for cancer pain: A prospective study
    • 20026951 10.1097/AJP.0b013e3181b0c82c
    • Nomiya T, Teruyama K, Wada H et al (2010) Time course of pain relief in patients treated with radiotherapy for cancer pain: a prospective study. Clin J Pain 26:38-42
    • (2010) Clin J Pain , vol.26 , pp. 38-42
    • Nomiya, T.1    Teruyama, K.2    Wada, H.3
  • 170
    • 0035310419 scopus 로고    scopus 로고
    • Functional reorganization of sensory pathways in the rat spinal dorsal horn following peripheral nerve injury
    • 11283238 1:CAS:528:DC%2BD3MXjs1OqsbY%3D 10.1111/j.1469-7793.2001.0241g.x
    • Okamoto M, Baba H, Goldstein PA et al (2001) Functional reorganization of sensory pathways in the rat spinal dorsal horn following peripheral nerve injury. J Physiol 532:241-250
    • (2001) J Physiol , vol.532 , pp. 241-250
    • Okamoto, M.1    Baba, H.2    Goldstein, P.A.3
  • 171
    • 0032550139 scopus 로고    scopus 로고
    • An acid sensing ion channel (ASIC) localizes to small primary afferent neurons in rats
    • 9601677 1:CAS:528:DyaK1cXjtFaksLY%3D 10.1097/00001756-199804200-00028
    • Olson TH, Riedl MS, Vulchanova L et al (1998) An acid sensing ion channel (ASIC) localizes to small primary afferent neurons in rats. NeuroReport 9:1109-1113
    • (1998) NeuroReport , vol.9 , pp. 1109-1113
    • Olson, T.H.1    Riedl, M.S.2    Vulchanova, L.3
  • 172
    • 0142259750 scopus 로고    scopus 로고
    • Strontium(89) chloride versus palliative local field radiotherapy in patients with hormonal escaped prostate cancer: A phase III study of the European Organisation for Research and Treatment of Cancer, Genitourinary Group
    • 14572748 1:CAS:528:DC%2BD3sXpsVWltr0%3D 10.1016/S0302-2838(03)00364-6
    • Oosterhof GO, Roberts JT, de Reijke TM et al (2003) Strontium(89) chloride versus palliative local field radiotherapy in patients with hormonal escaped prostate cancer: a phase III study of the European Organisation for Research and Treatment of Cancer, Genitourinary Group. Eur Urol 44:519-526
    • (2003) Eur Urol , vol.44 , pp. 519-526
    • Oosterhof, G.O.1    Roberts, J.T.2    De Reijke, T.M.3
  • 173
    • 0030077247 scopus 로고    scopus 로고
    • Pharmacological characterization of A-127722: An orally active and highly potent ETA-selective receptor antagonist
    • 8632312 1:CAS:528:DyaK28XhtFaksbw%3D
    • Opgenorth TJ, Adler AL, Calzadilla SV et al (1996) Pharmacological characterization of A-127722: an orally active and highly potent ETA-selective receptor antagonist. J Pharmacol Exp Ther 276:473-481
    • (1996) J Pharmacol Exp Ther , vol.276 , pp. 473-481
    • Opgenorth, T.J.1    Adler, A.L.2    Calzadilla, S.V.3
  • 174
    • 0037672705 scopus 로고    scopus 로고
    • A Phase I/II study of strontium-89 combined with gemcitabine in the treatment of patients with androgen independent prostate carcinoma and bone metastases
    • 12784333 1:CAS:528:DC%2BD3sXlt1Shtbg%3D 10.1002/cncr.11412
    • Pagliaro LC, Delpassand ES, Williams D et al (2003) A Phase I/II study of strontium-89 combined with gemcitabine in the treatment of patients with androgen independent prostate carcinoma and bone metastases. Cancer 97:2988-2994
    • (2003) Cancer , vol.97 , pp. 2988-2994
    • Pagliaro, L.C.1    Delpassand, E.S.2    Williams, D.3
  • 175
    • 4544377830 scopus 로고    scopus 로고
    • Radiopharmaceutical therapy for palliation of bone pain from osseous metastases
    • 15299062 1:CAS:528:DC%2BD2cXnsFSmu78%3D
    • Pandit-Taskar N, Batraki M, Divgi CR (2004) Radiopharmaceutical therapy for palliation of bone pain from osseous metastases. J Nucl Med 45:1358-1365
    • (2004) J Nucl Med , vol.45 , pp. 1358-1365
    • Pandit-Taskar, N.1    Batraki, M.2    Divgi, C.R.3
  • 176
    • 44849134528 scopus 로고    scopus 로고
    • Targeting SRC family kinases inhibits growth and lymph node metastases of prostate cancer in an orthotopic nude mouse model
    • 18451159 1:CAS:528:DC%2BD1cXltlSlsL4%3D 10.1158/0008-5472.CAN-07-2997
    • Park SI, Zhang J, Phillips KA et al (2008) Targeting SRC family kinases inhibits growth and lymph node metastases of prostate cancer in an orthotopic nude mouse model. Cancer Res 68:3323-3333
    • (2008) Cancer Res , vol.68 , pp. 3323-3333
    • Park, S.I.1    Zhang, J.2    Phillips, K.A.3
  • 177
    • 84860854128 scopus 로고    scopus 로고
    • Overall survival benefit and safety profile of radium-223 chloride, a first-in-class alpha-pharmaceutical: Results from a phase III randomized trial (ALSYMPCA) in patients with castration-resistant prostate cancer (CRPC) with bone metastases
    • Parker C, Heinrich D, O'Sullivan JM et al (2012) Overall survival benefit and safety profile of radium-223 chloride, a first-in-class alpha-pharmaceutical: results from a phase III randomized trial (ALSYMPCA) in patients with castration-resistant prostate cancer (CRPC) with bone metastases. J Clin Oncol 30(Suppl 5):8
    • (2012) J Clin Oncol , vol.30 , Issue.SUPPL. 5 , pp. 8
    • Parker, C.1    Heinrich, D.2    O'Sullivan, J.M.3
  • 178
    • 84871926771 scopus 로고    scopus 로고
    • A randomized, double-blind, dose-finding, multicenter, phase 2 study of radium chloride (Ra 223) in patients with bone metastases and castration-resistant prostate cancer
    • 23000088 1:CAS:528:DC%2BC38XhsVSltLvP 10.1016/j.eururo.2012.09.008
    • Parker CC, Pascoe S, Chodacki A et al (2013) A randomized, double-blind, dose-finding, multicenter, phase 2 study of radium chloride (Ra 223) in patients with bone metastases and castration-resistant prostate cancer. Eur Urol 63:189-197
    • (2013) Eur Urol , vol.63 , pp. 189-197
    • Parker, C.C.1    Pascoe, S.2    Chodacki, A.3
  • 179
    • 78649689220 scopus 로고    scopus 로고
    • Delayed reinnervation by nonpeptidergic nociceptive afferents of the glabrous skin of the rat hindpaw in a neuropathic pain model
    • 21120927 1:CAS:528:DC%2BC3MXmsFOgtw%3D%3D 10.1002/cne.22500
    • Peleshok JC, Ribeiro-da-Silva A (2011) Delayed reinnervation by nonpeptidergic nociceptive afferents of the glabrous skin of the rat hindpaw in a neuropathic pain model. J Comp Neurol 519:49-63
    • (2011) J Comp Neurol , vol.519 , pp. 49-63
    • Peleshok, J.C.1    Ribeiro-Da-Silva, A.2
  • 180
    • 20144387562 scopus 로고    scopus 로고
    • Tumor-induced injury of primary afferent sensory nerve fibers in bone cancer pain
    • 15817267 10.1016/j.expneurol.2004.11.028
    • Peters CM, Ghilardi JR, Keyser CP et al (2005) Tumor-induced injury of primary afferent sensory nerve fibers in bone cancer pain. Exp Neurol 193:85-100
    • (2005) Exp Neurol , vol.193 , pp. 85-100
    • Peters, C.M.1    Ghilardi, J.R.2    Keyser, C.P.3
  • 181
    • 0027252452 scopus 로고
    • Results of a randomized phase-III trial to evaluate the efficacy of strontium-89 adjuvant to local field external beam irradiation in the management of endocrine resistant metastatic prostate cancer
    • 8478230 1:STN:280:DyaK3s3jvFGntw%3D%3D 10.1016/0360-3016(93)90309-J
    • Porter AT, McEwan AJ, Powe JE et al (1993) Results of a randomized phase-III trial to evaluate the efficacy of strontium-89 adjuvant to local field external beam irradiation in the management of endocrine resistant metastatic prostate cancer. Int J Radiat Oncol Biol Phys 25:805-813
    • (1993) Int J Radiat Oncol Biol Phys , vol.25 , pp. 805-813
    • Porter, A.T.1    McEwan, A.J.2    Powe, J.E.3
  • 182
    • 78650307699 scopus 로고    scopus 로고
    • Metastatic bone disease: Role of transcription factors and future targets
    • 20561908 1:CAS:528:DC%2BC3cXhs1Wgu7rM 10.1016/j.bone.2010.05.035
    • Pratap J, Lian JB, Stein GS (2011) Metastatic bone disease: role of transcription factors and future targets. Bone 48:30-36
    • (2011) Bone , vol.48 , pp. 30-36
    • Pratap, J.1    Lian, J.B.2    Stein, G.S.3
  • 183
    • 71149092895 scopus 로고    scopus 로고
    • The molecular mechanism behind bone remodelling: A review
    • 19319579 10.1007/s00784-009-0268-2
    • Proff P, Romer P (2009) The molecular mechanism behind bone remodelling: a review. Clin Oral Investig 13:355-362
    • (2009) Clin Oral Investig , vol.13 , pp. 355-362
    • Proff, P.1    Romer, P.2
  • 184
    • 0028233520 scopus 로고
    • A comparison of the palliative effects of strontium-89 and external beam radiotherapy in metastatic prostate cancer
    • 7518932 1:STN:280:DyaK2czhs1yitQ%3D%3D 10.1016/0167-8140(94)90411-1
    • Quilty PM, Kirk D, Bolger JJ et al (1994) A comparison of the palliative effects of strontium-89 and external beam radiotherapy in metastatic prostate cancer. Radiother Oncol 31:33-40
    • (1994) Radiother Oncol , vol.31 , pp. 33-40
    • Quilty, P.M.1    Kirk, D.2    Bolger, J.J.3
  • 185
    • 84859796622 scopus 로고    scopus 로고
    • Novel therapies in benign and malignant bone diseases
    • 22401778 1:CAS:528:DC%2BC38Xkt1ygtb0%3D 10.1016/j.pharmthera.2012.02.005
    • Rachner TD, Hadji P, Hofbauer LC (2012) Novel therapies in benign and malignant bone diseases. Pharmacol Ther 134:338-344
    • (2012) Pharmacol Ther , vol.134 , pp. 338-344
    • Rachner, T.D.1    Hadji, P.2    Hofbauer, L.C.3
  • 186
    • 77950520827 scopus 로고    scopus 로고
    • Treatment of painful bone metastases
    • 20234353 10.1038/nrclinonc.2010.17
    • Rades D, Schild SE, Abrahm JL (2010) Treatment of painful bone metastases. Nat Rev Clin Oncol 7:220-229
    • (2010) Nat Rev Clin Oncol , vol.7 , pp. 220-229
    • Rades, D.1    Schild, S.E.2    Abrahm, J.L.3
  • 187
    • 3242758909 scopus 로고    scopus 로고
    • Complete Freunds adjuvant-induced peripheral inflammation evokes glial activation and proinflammatory cytokine expression in the CNS
    • 15233755 10.1111/j.1460-9568.2004.03514.x
    • Raghavendra V, Tanga FY, DeLeo JA (2004) Complete Freunds adjuvant-induced peripheral inflammation evokes glial activation and proinflammatory cytokine expression in the CNS. Eur J Neurosci 20:467-473
    • (2004) Eur J Neurosci , vol.20 , pp. 467-473
    • Raghavendra, V.1    Tanga, F.Y.2    Deleo, J.A.3
  • 188
    • 0030825636 scopus 로고    scopus 로고
    • Pain affect encoded in human anterior cingulate but not somatosensory cortex
    • 9252330 1:CAS:528:DyaK2sXltlGjurc%3D 10.1126/science.277.5328.968
    • Rainville P, Duncan GH, Price DD et al (1997) Pain affect encoded in human anterior cingulate but not somatosensory cortex. Science 277:968-971
    • (1997) Science , vol.277 , pp. 968-971
    • Rainville, P.1    Duncan, G.H.2    Price, D.D.3
  • 189
    • 0031417685 scopus 로고    scopus 로고
    • A dose-controlled study of 153Sm-ethylenediaminetetramethylenephosphonate (EDTMP) in the treatment of patients with painful bone metastases
    • 9389919 1:CAS:528:DyaK2sXntlOjt7k%3D 10.1016/S0959-8049(97)00155-X
    • Resche I, Chatal JF, Pecking A et al (1997) A dose-controlled study of 153Sm-ethylenediaminetetramethylenephosphonate (EDTMP) in the treatment of patients with painful bone metastases. Eur J Cancer 33:1583-1591
    • (1997) Eur J Cancer , vol.33 , pp. 1583-1591
    • Resche, I.1    Chatal, J.F.2    Pecking, A.3
  • 190
    • 0027318474 scopus 로고
    • Clinical experience with strontium-89 in prostatic and breast cancer patients
    • 8503027 1:STN:280:DyaK3s3ns1eitA%3D%3D
    • Robinson RG, Preston DF, Baxter KG et al (1993) Clinical experience with strontium-89 in prostatic and breast cancer patients. Semin Oncol 20:44-48
    • (1993) Semin Oncol , vol.20 , pp. 44-48
    • Robinson, R.G.1    Preston, D.F.2    Baxter, K.G.3
  • 191
    • 52449124149 scopus 로고    scopus 로고
    • Wnt signaling and prostate cancer
    • 18673243 1:CAS:528:DC%2BD1cXnsVOqtLc%3D 10.2174/138945008784911831
    • Robinson DR, Zylstra CR, Williams BO (2008) Wnt signaling and prostate cancer. Curr Drug Targets 9:571-580
    • (2008) Curr Drug Targets , vol.9 , pp. 571-580
    • Robinson, D.R.1    Zylstra, C.R.2    Williams, B.O.3
  • 192
    • 16644363491 scopus 로고    scopus 로고
    • Use of bisphosphonates can dramatically improve pain in advanced hormone-refractory prostate cancer patients
    • 15534620 1:CAS:528:DC%2BD2cXhtVGqu77M 10.1038/sj.pcan.4500752
    • Rodrigues P, Hering F, Campagnari JC (2004) Use of bisphosphonates can dramatically improve pain in advanced hormone-refractory prostate cancer patients. Prostate Cancer Prostatic Dis 7:350-354
    • (2004) Prostate Cancer Prostatic Dis , vol.7 , pp. 350-354
    • Rodrigues, P.1    Hering, F.2    Campagnari, J.C.3
  • 193
    • 0035425227 scopus 로고    scopus 로고
    • Biology of osteoclast activation in cancer
    • 11481364 1:CAS:528:DC%2BD3MXmtlGhu78%3D
    • Roodman GD (2001) Biology of osteoclast activation in cancer. J Clin Oncol 19:3562-3571
    • (2001) J Clin Oncol , vol.19 , pp. 3562-3571
    • Roodman, G.D.1
  • 195
    • 77951212664 scopus 로고    scopus 로고
    • Evaluation of the safety, pharmacokinetics and treatment effects of an alpha(nu)beta(3) integrin inhibitor on bone turnover and disease activity in men with hormone-refractory prostate cancer and bone metastases
    • 20398037 10.1111/j.1743-7563.2009.01266.x
    • Rosenthal MA, Davidson P, Rolland F et al (2010) Evaluation of the safety, pharmacokinetics and treatment effects of an alpha(nu)beta(3) integrin inhibitor on bone turnover and disease activity in men with hormone-refractory prostate cancer and bone metastases. Asia Pac J Clin Oncol 6:42-48
    • (2010) Asia Pac J Clin Oncol , vol.6 , pp. 42-48
    • Rosenthal, M.A.1    Davidson, P.2    Rolland, F.3
  • 196
    • 84884816954 scopus 로고    scopus 로고
    • Evaluation of pain in breast and prostate cancer bone metastasis rat models
    • Abstracts 2005:684
    • Roudier MP, Haynes K, Feldman R et al (2005) Evaluation of pain in breast and prostate cancer bone metastasis rat models. AACR Meeting Abstracts 2005:684
    • (2005) AACR Meeting
    • Roudier, M.P.1    Haynes, K.2    Feldman, R.3
  • 197
    • 2342505738 scopus 로고    scopus 로고
    • Behavioral and histological effects of endoneurial administration of nerve growth factor: Possible implications in neuropathic pain
    • 15140639 1:CAS:528:DC%2BD2cXktVClsbs%3D 10.1016/j.brainres.2004.02.001
    • Ruiz G, Ceballos D, Banos JE (2004) Behavioral and histological effects of endoneurial administration of nerve growth factor: possible implications in neuropathic pain. Brain Res 1011:1-6
    • (2004) Brain Res , vol.1011 , pp. 1-6
    • Ruiz, G.1    Ceballos, D.2    Banos, J.E.3
  • 198
    • 0032859149 scopus 로고    scopus 로고
    • The pharmacology of bisphosphonates and new insights into their mechanisms of action
    • 10510215 1:CAS:528:DyaK1MXmsFOis7o%3D 10.1002/jbmr.5650140212
    • Russell RG, Rogers MJ, Frith JC et al (1999) The pharmacology of bisphosphonates and new insights into their mechanisms of action. J Bone Miner Res 14:53-65
    • (1999) J Bone Miner Res , vol.14 , pp. 53-65
    • Russell, R.G.1    Rogers, M.J.2    Frith, J.C.3
  • 199
    • 77749261162 scopus 로고    scopus 로고
    • Anti-endothelin drugs in solid tumors
    • 20102289 1:CAS:528:DC%2BC3cXivFelsrk%3D 10.1517/14728210903571667
    • Russo A, Bronte G, Rizzo S et al (2010) Anti-endothelin drugs in solid tumors. Expert Opin Emerg Drugs 15:27-40
    • (2010) Expert Opin Emerg Drugs , vol.15 , pp. 27-40
    • Russo, A.1    Bronte, G.2    Rizzo, S.3
  • 200
    • 3042851918 scopus 로고    scopus 로고
    • Dose-ranging study of the safety and pharmacokinetics of atrasentan in patients with refractory malignancies
    • 15240529 1:CAS:528:DC%2BD2cXlsVWlt78%3D 10.1158/1078-0432.CCR-04-0083
    • Ryan CW, Vogelzang NJ, Vokes EE et al (2004) Dose-ranging study of the safety and pharmacokinetics of atrasentan in patients with refractory malignancies. Clin Cancer Res 10:4406-4411
    • (2004) Clin Cancer Res , vol.10 , pp. 4406-4411
    • Ryan, C.W.1    Vogelzang, N.J.2    Vokes, E.E.3
  • 201
    • 78449284191 scopus 로고    scopus 로고
    • Bone-marker levels in patients with prostate cancer: Potential correlations with outcomes
    • 20489645 10.1097/SPC.0b013e32833ac6d6
    • Saad F, Lipton A (2010a) Bone-marker levels in patients with prostate cancer: potential correlations with outcomes. Curr Opin Support Palliat Care 4:127-134
    • (2010) Curr Opin Support Palliat Care , vol.4 , pp. 127-134
    • Saad, F.1    Lipton, A.2
  • 202
    • 77950616066 scopus 로고    scopus 로고
    • SRC kinase inhibition: Targeting bone metastases and tumor growth in prostate and breast cancer
    • 20015594 1:CAS:528:DC%2BC3cXjtFyhsb8%3D 10.1016/j.ctrv.2009.11.005
    • Saad F, Lipton A (2010b) SRC kinase inhibition: targeting bone metastases and tumor growth in prostate and breast cancer. Cancer Treat Rev 36:177-184
    • (2010) Cancer Treat Rev , vol.36 , pp. 177-184
    • Saad, F.1    Lipton, A.2
  • 203
    • 0037009822 scopus 로고    scopus 로고
    • A randomized, placebo-controlled trial of zoledronic acid in patients with hormone-refractory metastatic prostate carcinoma
    • 12359855 1:CAS:528:DC%2BD38XosVans7g%3D 10.1093/jnci/94.19.1458
    • Saad F, Gleason DM, Murray R et al (2002) A randomized, placebo-controlled trial of zoledronic acid in patients with hormone-refractory metastatic prostate carcinoma. J Natl Cancer Inst 94:1458-1468
    • (2002) J Natl Cancer Inst , vol.94 , pp. 1458-1468
    • Saad, F.1    Gleason, D.M.2    Murray, R.3
  • 204
    • 2942518111 scopus 로고    scopus 로고
    • Long-term efficacy of zoledronic acid for the prevention of skeletal complications in patients with metastatic hormone-refractory prostate cancer
    • 15173273 1:CAS:528:DC%2BD2cXkvVSrurk%3D 10.1093/jnci/djh141
    • Saad F, Gleason DM, Murray R et al (2004) Long-term efficacy of zoledronic acid for the prevention of skeletal complications in patients with metastatic hormone-refractory prostate cancer. J Natl Cancer Inst 96:879-882
    • (2004) J Natl Cancer Inst , vol.96 , pp. 879-882
    • Saad, F.1    Gleason, D.M.2    Murray, R.3
  • 205
    • 0037115425 scopus 로고    scopus 로고
    • Simultaneous reduction in cancer pain, bone destruction, and tumor growth by selective inhibition of cyclooxygenase-2
    • 12499278 1:CAS:528:DC%2BD3sXhtV2jug%3D%3D
    • Sabino MA, Ghilardi JR, Jongen JL et al (2002) Simultaneous reduction in cancer pain, bone destruction, and tumor growth by selective inhibition of cyclooxygenase-2. Cancer Res 62:7343-7349
    • (2002) Cancer Res , vol.62 , pp. 7343-7349
    • Sabino, M.A.1    Ghilardi, J.R.2    Jongen, J.L.3
  • 206
    • 0032506007 scopus 로고    scopus 로고
    • Impaired osteoclastic bone resorption leads to osteopetrosis in cathepsin-K-deficient mice
    • 9811821 1:CAS:528:DyaK1cXnsVGhtL4%3D 10.1073/pnas.95.23.13453
    • Saftig P, Hunziker E, Wehmeyer O et al (1998) Impaired osteoclastic bone resorption leads to osteopetrosis in cathepsin-K-deficient mice. Proc Natl Acad Sci USA 95:13453-13458
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 13453-13458
    • Saftig, P.1    Hunziker, E.2    Wehmeyer, O.3
  • 207
    • 2342509633 scopus 로고    scopus 로고
    • Samarium-153-lexidronam complex for treatment of painful bone metastases in hormone-refractory prostate cancer
    • 15134985 10.1016/j.urology.2004.01.034
    • Sartor O, Reid RH, Hoskin PJ et al (2004) Samarium-153-lexidronam complex for treatment of painful bone metastases in hormone-refractory prostate cancer. Urology 63:940-945
    • (2004) Urology , vol.63 , pp. 940-945
    • Sartor, O.1    Reid, R.H.2    Hoskin, P.J.3
  • 208
    • 76949090950 scopus 로고    scopus 로고
    • Bone health and prostate cancer
    • 19901958 1:STN:280:DC%2BC3c%2Fps1ShtA%3D%3D 10.1038/pcan.2009.50
    • Saylor PJ, Smith MR (2010) Bone health and prostate cancer. Prostate Cancer Prostatic Dis 13:20-27
    • (2010) Prostate Cancer Prostatic Dis , vol.13 , pp. 20-27
    • Saylor, P.J.1    Smith, M.R.2
  • 209
    • 84871918834 scopus 로고    scopus 로고
    • New and emerging therapies for bone metastases in genitourinary cancers
    • 23201471 1:CAS:528:DC%2BC38Xhsl2jurzI 10.1016/j.eururo.2012.10.007
    • Saylor PJ, Armstrong AJ, Fizazi K et al (2013) New and emerging therapies for bone metastases in genitourinary cancers. Eur Urol 63:309-320
    • (2013) Eur Urol , vol.63 , pp. 309-320
    • Saylor, P.J.1    Armstrong, A.J.2    Fizazi, K.3
  • 210
    • 79151468942 scopus 로고    scopus 로고
    • A phase i study of zibotentan (ZD4054) in patients with metastatic, castrate-resistant prostate cancer
    • 19763400 1:CAS:528:DC%2BC3MXisVOjtg%3D%3D 10.1007/s10637-009-9318-5
    • Schelman WR, Liu G, Wilding G et al (2011) A phase I study of zibotentan (ZD4054) in patients with metastatic, castrate-resistant prostate cancer. Invest New Drugs 29:118-125
    • (2011) Invest New Drugs , vol.29 , pp. 118-125
    • Schelman, W.R.1    Liu, G.2    Wilding, G.3
  • 211
    • 0035126390 scopus 로고    scopus 로고
    • A N-terminal PTHrP peptide fragment void of a PTH/PTHrP-receptor binding domain activates cardiac ET(A) receptors
    • 11159691 1:CAS:528:DC%2BD3MXht1Sgurs%3D 10.1038/sj.bjp.0703830
    • Schluter KD, Katzer C, Piper HM (2001) A N-terminal PTHrP peptide fragment void of a PTH/PTHrP-receptor binding domain activates cardiac ET(A) receptors. Br J Pharmacol 132:427-432
    • (2001) Br J Pharmacol , vol.132 , pp. 427-432
    • Schluter, K.D.1    Katzer, C.2    Piper, H.M.3
  • 212
    • 77953501129 scopus 로고    scopus 로고
    • Mechanism of cancer pain
    • 20539035 1:CAS:528:DC%2BC3cXptV2js78%3D 10.1124/mi.10.3.7
    • Schmidt BL, Hamamoto DT, Simone DA et al (2010) Mechanism of cancer pain. Mol Interv 10:164-178
    • (2010) Mol Interv , vol.10 , pp. 164-178
    • Schmidt, B.L.1    Hamamoto, D.T.2    Simone, D.A.3
  • 213
    • 78650304364 scopus 로고    scopus 로고
    • Integrins and bone metastasis: Integrating tumor cell and stromal cell interactions
    • 20850578 1:CAS:528:DC%2BC3cXhs1Wgu7rJ 10.1016/j.bone.2010.09.016
    • Schneider JG, Amend SR, Weilbaecher KN (2011) Integrins and bone metastasis: integrating tumor cell and stromal cell interactions. Bone 48:54-65
    • (2011) Bone , vol.48 , pp. 54-65
    • Schneider, J.G.1    Amend, S.R.2    Weilbaecher, K.N.3
  • 214
    • 23744437312 scopus 로고    scopus 로고
    • Blocking caspase activity prevents transsynaptic neuronal apoptosis and the loss of inhibition in lamina II of the dorsal horn after peripheral nerve injury
    • 16093381 1:CAS:528:DC%2BD2MXpsFGitbk%3D 10.1523/JNEUROSCI.1526-05.2005
    • Scholz J, Broom DC, Youn DH et al (2005) Blocking caspase activity prevents transsynaptic neuronal apoptosis and the loss of inhibition in lamina II of the dorsal horn after peripheral nerve injury. J Neurosci 25:7317-7323
    • (2005) J Neurosci , vol.25 , pp. 7317-7323
    • Scholz, J.1    Broom, D.C.2    Youn, D.H.3
  • 215
    • 34548401627 scopus 로고    scopus 로고
    • Clinical development of anti-RANKL therapy
    • 17634146 10.1186/ar2171 1:CAS:528:DC%2BD2sXot1Smuro%3D
    • Schwarz EM, Ritchlin CT (2007) Clinical development of anti-RANKL therapy. Arthritis Res Ther 9:S7
    • (2007) Arthritis Res Ther , vol.9 , pp. 7
    • Schwarz, E.M.1    Ritchlin, C.T.2
  • 216
    • 0033573528 scopus 로고    scopus 로고
    • Neurochemical and cellular reorganization of the spinal cord in a murine model of bone cancer pain
    • 10594070 1:CAS:528:DyaK1MXotVyjsbs%3D
    • Schwei MJ, Honore P, Rogers SD et al (1999) Neurochemical and cellular reorganization of the spinal cord in a murine model of bone cancer pain. J Neurosci 19:10886-10897
    • (1999) J Neurosci , vol.19 , pp. 10886-10897
    • Schwei, M.J.1    Honore, P.2    Rogers, S.D.3
  • 217
    • 0036152138 scopus 로고    scopus 로고
    • Effects of low-dose cisplatin on 89Sr therapy for painful bone metastases from prostate cancer: A randomized clinical trial
    • 11801708 1:CAS:528:DC%2BD38XksVynu7g%3D
    • Sciuto R, Festa A, Rea S et al (2002) Effects of low-dose cisplatin on 89Sr therapy for painful bone metastases from prostate cancer: a randomized clinical trial. J Nucl Med 43:79-86
    • (2002) J Nucl Med , vol.43 , pp. 79-86
    • Sciuto, R.1    Festa, A.2    Rea, S.3
  • 218
    • 0026544124 scopus 로고
    • Role of the alpha v beta 3 integrin in human melanoma cell invasion
    • 1371877 1:CAS:528:DyaK38XhslWhu74%3D 10.1073/pnas.89.5.1557
    • Seftor RE, Seftor EA, Gehlsen KR et al (1992) Role of the alpha v beta 3 integrin in human melanoma cell invasion. Proc Natl Acad Sci USA 89:1557-1561
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 1557-1561
    • Seftor, R.E.1    Seftor, E.A.2    Gehlsen, K.R.3
  • 219
    • 43949092127 scopus 로고    scopus 로고
    • The use of molecular markers of bone turnover in the management of patients with metastatic bone disease
    • 1:CAS:528:DC%2BD1cXnvFensbo%3D 10.1111/j.1365-2265.2007.03112.x
    • Seibel MJ (2008) The use of molecular markers of bone turnover in the management of patients with metastatic bone disease. Clin Endocrinol (Oxf) 68:839-849
    • (2008) Clin Endocrinol (Oxf) , vol.68 , pp. 839-849
    • Seibel, M.J.1
  • 220
    • 0031954325 scopus 로고    scopus 로고
    • Palliation of pain associated with metastatic bone cancer using samarium-153 lexidronam: A double-blind placebo-controlled clinical trial
    • 9552068 1:CAS:528:DyaK1cXis1Ghtrs%3D
    • Serafini AN, Houston SJ, Resche I et al (1998) Palliation of pain associated with metastatic bone cancer using samarium-153 lexidronam: a double-blind placebo-controlled clinical trial. J Clin Oncol 16:1574-1581
    • (1998) J Clin Oncol , vol.16 , pp. 1574-1581
    • Serafini, A.N.1    Houston, S.J.2    Resche, I.3
  • 221
    • 78650306070 scopus 로고    scopus 로고
    • Dysregulation of developmental pathways in bone metastasis
    • 20630490 1:CAS:528:DC%2BC3cXhs1Wgu73L 10.1016/j.bone.2010.07.005
    • Sethi N, Kang Y (2011) Dysregulation of developmental pathways in bone metastasis. Bone 48:16-22
    • (2011) Bone , vol.48 , pp. 16-22
    • Sethi, N.1    Kang, Y.2
  • 223
    • 78650932925 scopus 로고    scopus 로고
    • Changes in response properties of nociceptive dorsal horn neurons in a murine model of cancer pain
    • 18958372
    • Simone DA, Khasabov SG, Hamamoto DT (2008) Changes in response properties of nociceptive dorsal horn neurons in a murine model of cancer pain. Sheng Li Xue Bao 60:635-644
    • (2008) Sheng Li Xue Bao , vol.60 , pp. 635-644
    • Simone, D.A.1    Khasabov, S.G.2    Hamamoto, D.T.3
  • 224
    • 0642337996 scopus 로고    scopus 로고
    • Combined analysis of two multicenter, randomized, placebo-controlled studies of pamidronate disodium for the palliation of bone pain in men with metastatic prostate cancer
    • 14581438 1:CAS:528:DC%2BD2cXpsVWqu7w%3D 10.1200/JCO.2003.05.147
    • Small EJ, Smith MR, Seaman JJ et al (2003) Combined analysis of two multicenter, randomized, placebo-controlled studies of pamidronate disodium for the palliation of bone pain in men with metastatic prostate cancer. J Clin Oncol 21:4277-4284
    • (2003) J Clin Oncol , vol.21 , pp. 4277-4284
    • Small, E.J.1    Smith, M.R.2    Seaman, J.J.3
  • 225
    • 0038503580 scopus 로고    scopus 로고
    • Role of strontium-89 as adjuvant to palliative external beam radiotherapy is questionable: Results of a double-blind randomized study
    • 12873686 10.1016/S0360-3016(03)00274-8
    • Smeland S, Erikstein B, Aas M et al (2003) Role of strontium-89 as adjuvant to palliative external beam radiotherapy is questionable: results of a double-blind randomized study. Int J Radiat Oncol Biol Phys 56:1397-1404
    • (2003) Int J Radiat Oncol Biol Phys , vol.56 , pp. 1397-1404
    • Smeland, S.1    Erikstein, B.2    Aas, M.3
  • 226
    • 85035045854 scopus 로고    scopus 로고
    • Pain pharmacology and the pharmacological management of pain
    • Unruh AM, Strong J, Baxter GD (eds) chap 11, 2nd edn. Churchill Livingstone, London (in press)
    • Smith MT, Muralidharan A (2013) Pain pharmacology and the pharmacological management of pain. In: Unruh AM, Strong J, Baxter GD (eds) Pain: a textbook for health professionals, chap 11, 2nd edn. Churchill Livingstone, London (in press)
    • (2013) Pain: A Textbook for Health Professionals
    • Smith, M.T.1    Muralidharan, A.2
  • 227
    • 0029048380 scopus 로고
    • Quantitative neuropathology of a focal nerve injury causing hyperalgesia
    • 7666051 1:STN:280:DyaK2MzpsFCnsQ%3D%3D 10.1097/00005072-199509000-00004
    • Sommer C, Lalonde A, Heckman HM et al (1995) Quantitative neuropathology of a focal nerve injury causing hyperalgesia. J Neuropathol Exp Neurol 54:635-643
    • (1995) J Neuropathol Exp Neurol , vol.54 , pp. 635-643
    • Sommer, C.1    Lalonde, A.2    Heckman, H.M.3
  • 228
    • 0028587765 scopus 로고
    • A study of early ongoing activity in dorsal horn units following sciatic nerve constriction
    • 7696614 1:STN:280:DyaK2M3htVKnsw%3D%3D 10.1097/00001756-199412000-00051
    • Sotgiu ML, Biella G, Riva L (1994) A study of early ongoing activity in dorsal horn units following sciatic nerve constriction. NeuroReport 5:2609-2612
    • (1994) NeuroReport , vol.5 , pp. 2609-2612
    • Sotgiu, M.L.1    Biella, G.2    Riva, L.3
  • 229
    • 0028989395 scopus 로고
    • Poststimulus afterdischarges of spinal WDR and NS units in rats with chronic nerve constriction
    • 7632886 1:STN:280:DyaK2MzlvFeksA%3D%3D 10.1097/00001756-199505090-00018
    • Sotgiu ML, Biella G, Riva L (1995) Poststimulus afterdischarges of spinal WDR and NS units in rats with chronic nerve constriction. NeuroReport 6:1021-1024
    • (1995) NeuroReport , vol.6 , pp. 1021-1024
    • Sotgiu, M.L.1    Biella, G.2    Riva, L.3
  • 230
    • 76149104939 scopus 로고    scopus 로고
    • ERK1/2 mitogen-activated protein kinase phosphorylates sodium channel Na(v)1.7 and alters its gating properties
    • 20130174 1:CAS:528:DC%2BC3cXitV2jtbo%3D 10.1523/JNEUROSCI.4872-09.2010
    • Stamboulian S, Choi JS, Ahn HS et al (2010) ERK1/2 mitogen-activated protein kinase phosphorylates sodium channel Na(v)1.7 and alters its gating properties. J Neurosci 30:1637-1647
    • (2010) J Neurosci , vol.30 , pp. 1637-1647
    • Stamboulian, S.1    Choi, J.S.2    Ahn, H.S.3
  • 231
    • 67651180563 scopus 로고    scopus 로고
    • Effect of the cathepsin K inhibitor odanacatib on bone resorption biomarkers in healthy postmenopausal women: Two double-blind, randomized, placebo-controlled phase i studies
    • 19421185 1:CAS:528:DC%2BD1MXovFOrt7c%3D 10.1038/clpt.2009.60
    • Stoch SA, Zajic S, Stone J et al (2009) Effect of the cathepsin K inhibitor odanacatib on bone resorption biomarkers in healthy postmenopausal women: two double-blind, randomized, placebo-controlled phase I studies. Clin Pharmacol Ther 86:175-182
    • (2009) Clin Pharmacol Ther , vol.86 , pp. 175-182
    • Stoch, S.A.1    Zajic, S.2    Stone, J.3
  • 232
    • 0035173913 scopus 로고    scopus 로고
    • Specific inhibition of cyclooxygenase-2 results in inhibition of proliferation of oral cancer cell lines via suppression of prostaglandin E2 production
    • 11140899 1:CAS:528:DC%2BD3MXitFSksQ%3D%3D 10.1034/j.1600-0714.2001. 300107.x
    • Sumitani K, Kamijo R, Toyoshima T et al (2001) Specific inhibition of cyclooxygenase-2 results in inhibition of proliferation of oral cancer cell lines via suppression of prostaglandin E2 production. J Oral Pathol Med 30:41-47
    • (2001) J Oral Pathol Med , vol.30 , pp. 41-47
    • Sumitani, K.1    Kamijo, R.2    Toyoshima, T.3
  • 233
    • 0038386613 scopus 로고    scopus 로고
    • Src family kinases in tumor progression and metastasis
    • 12884910 1:CAS:528:DC%2BD3sXjslyiu74%3D 10.1023/A:1023772912750
    • Summy JM, Gallick GE (2003) Src family kinases in tumor progression and metastasis. Cancer Metastasis Rev 22:337-358
    • (2003) Cancer Metastasis Rev , vol.22 , pp. 337-358
    • Summy, J.M.1    Gallick, G.E.2
  • 234
    • 0038360798 scopus 로고    scopus 로고
    • Expression of CXCR4 and CXCL12 (SDF-1) in human prostate cancers (PCa) in vivo
    • 12761880 1:CAS:528:DC%2BD3sXksVKktLc%3D 10.1002/jcb.10522
    • Sun YX, Wang J, Shelburne CE et al (2003) Expression of CXCR4 and CXCL12 (SDF-1) in human prostate cancers (PCa) in vivo. J Cell Biochem 89:462-473
    • (2003) J Cell Biochem , vol.89 , pp. 462-473
    • Sun, Y.X.1    Wang, J.2    Shelburne, C.E.3
  • 235
    • 19944433608 scopus 로고    scopus 로고
    • Skeletal localization and neutralization of the SDF-1(CXCL12)/CXCR4 axis blocks prostate cancer metastasis and growth in osseous sites in vivo
    • 15647826 1:CAS:528:DC%2BD2MXhsFars7w%3D 10.1359/JBMR.041109
    • Sun YX, Schneider A, Jung Y et al (2005) Skeletal localization and neutralization of the SDF-1(CXCL12)/CXCR4 axis blocks prostate cancer metastasis and growth in osseous sites in vivo. J Bone Miner Res 20:318-329
    • (2005) J Bone Miner Res , vol.20 , pp. 318-329
    • Sun, Y.X.1    Schneider, A.2    Jung, Y.3
  • 236
    • 0034125842 scopus 로고    scopus 로고
    • Enlargement of the receptive field size to low intensity mechanical stimulation in the rat spinal nerve ligation model of neuropathy
    • 10833315 1:STN:280:DC%2BD3c3psV2qtQ%3D%3D 10.1006/exnr.2000.7371
    • Suzuki R, Kontinen VK, Matthews E et al (2000) Enlargement of the receptive field size to low intensity mechanical stimulation in the rat spinal nerve ligation model of neuropathy. Exp Neurol 163:408-413
    • (2000) Exp Neurol , vol.163 , pp. 408-413
    • Suzuki, R.1    Kontinen, V.K.2    Matthews, E.3
  • 237
    • 0042140585 scopus 로고    scopus 로고
    • Palliation of metastatic bone pain: Single fraction versus multifraction radiotherapy - A systematic review of randomised trials
    • 1:STN:280:DC%2BD3svmt1Cnsw%3D%3D 10.1016/S0936-6555(03)00113-4
    • Sze WM, Shelley MD, Held I et al (2003) Palliation of metastatic bone pain: single fraction versus multifraction radiotherapy - a systematic review of randomised trials. Clin Oncol (R Coll Radiol) 15:345-352
    • (2003) Clin Oncol (R Coll Radiol) , vol.15 , pp. 345-352
    • Sze, W.M.1    Shelley, M.D.2    Held, I.3
  • 238
    • 3843127661 scopus 로고    scopus 로고
    • Palliation of metastatic bone pain: Single fraction versus multifraction radiotherapy - A systematic review of the randomised trials
    • Sze WM, Shelley M, Held I et al (2004) Palliation of metastatic bone pain: single fraction versus multifraction radiotherapy - a systematic review of the randomised trials. Cochrane Database Syst Rev 2:CD004721
    • (2004) Cochrane Database Syst Rev , vol.2
    • Sze, W.M.1    Shelley, M.2    Held, I.3
  • 239
    • 0037085938 scopus 로고    scopus 로고
    • Use of the stromal cell-derived factor-1/CXCR4 pathway in prostate cancer metastasis to bone
    • 11912162 1:CAS:528:DC%2BD38XisVSit70%3D
    • Taichman RS, Cooper C, Keller ET et al (2002) Use of the stromal cell-derived factor-1/CXCR4 pathway in prostate cancer metastasis to bone. Cancer Res 62:1832-1837
    • (2002) Cancer Res , vol.62 , pp. 1832-1837
    • Taichman, R.S.1    Cooper, C.2    Keller, E.T.3
  • 241
    • 77953090345 scopus 로고    scopus 로고
    • CXCL12 (SDF-1)/CXCR4 pathway in cancer
    • 20484021 1:CAS:528:DC%2BC3cXms1Ojs7o%3D 10.1158/1078-0432.CCR-09-2329
    • Teicher BA, Fricker SP (2010) CXCL12 (SDF-1)/CXCR4 pathway in cancer. Clin Cancer Res 16:2927-2931
    • (2010) Clin Cancer Res , vol.16 , pp. 2927-2931
    • Teicher, B.A.1    Fricker, S.P.2
  • 242
    • 77955844659 scopus 로고    scopus 로고
    • Treatment with a sclerostin antibody increases cancellous bone formation and bone mass regardless of marrow composition in adult female rats
    • 20561907 1:CAS:528:DC%2BC3cXhtVGmur%2FI 10.1016/j.bone.2010.05.032
    • Tian X, Setterberg RB, Li X et al (2010) Treatment with a sclerostin antibody increases cancellous bone formation and bone mass regardless of marrow composition in adult female rats. Bone 47:529-533
    • (2010) Bone , vol.47 , pp. 529-533
    • Tian, X.1    Setterberg, R.B.2    Li, X.3
  • 243
    • 0019972743 scopus 로고
    • The palliation of symptomatic osseous metastases: Final results of the Study by the Radiation Therapy Oncology Group
    • 6178497 1:STN:280:DyaL383jtlCjug%3D%3D 10.1002/1097-0142(19820901)50: 5<893: AID-CNCR2820500515>3.0.CO;2-Y
    • Tong D, Gillick L, Hendrickson FR (1982) The palliation of symptomatic osseous metastases: final results of the Study by the Radiation Therapy Oncology Group. Cancer 50:893-899
    • (1982) Cancer , vol.50 , pp. 893-899
    • Tong, D.1    Gillick, L.2    Hendrickson, F.R.3
  • 244
    • 79953076595 scopus 로고    scopus 로고
    • Preliminary study of the specific endothelin a receptor antagonist zibotentan in combination with docetaxel in patients with metastatic castration-resistant prostate cancer
    • 21271613 1:CAS:528:DC%2BC3MXptFKnu7w%3D
    • Trump DL, Payne H, Miller K et al (2011) Preliminary study of the specific endothelin a receptor antagonist zibotentan in combination with docetaxel in patients with metastatic castration-resistant prostate cancer. Prostate 71:1264-1275
    • (2011) Prostate , vol.71 , pp. 1264-1275
    • Trump, D.L.1    Payne, H.2    Miller, K.3
  • 245
    • 43049170371 scopus 로고    scopus 로고
    • Current trials using bone-targeting agents in prostate cancer
    • 18303481 1:CAS:528:DC%2BD1cXivF2jtb4%3D 10.1097/PPO.0b013e318161d32d
    • Tu SM, Lin SH (2008) Current trials using bone-targeting agents in prostate cancer. Cancer J 14:35-39
    • (2008) Cancer J , vol.14 , pp. 35-39
    • Tu, S.M.1    Lin, S.H.2
  • 246
    • 0345600040 scopus 로고    scopus 로고
    • Alterations in dorsal horn neurones in a rat model of cancer-induced bone pain
    • 14659517 1:STN:280:DC%2BD3srotVektw%3D%3D 10.1016/j.pain.2003.08.002
    • Urch CE, Donovan-Rodriguez T, Dickenson AH (2003) Alterations in dorsal horn neurones in a rat model of cancer-induced bone pain. Pain 106:347-356
    • (2003) Pain , vol.106 , pp. 347-356
    • Urch, C.E.1    Donovan-Rodriguez, T.2    Dickenson, A.H.3
  • 247
    • 77954877647 scopus 로고    scopus 로고
    • The role of glia and the immune system in the development and maintenance of neuropathic pain
    • 20384965 10.1111/j.1533-2500.2010.00367.x
    • Vallejo R, Tilley DM, Vogel L et al (2010) The role of glia and the immune system in the development and maintenance of neuropathic pain. Pain Pract 10:167-184
    • (2010) Pain Pract , vol.10 , pp. 167-184
    • Vallejo, R.1    Tilley, D.M.2    Vogel, L.3
  • 248
    • 0034999898 scopus 로고    scopus 로고
    • Monitoring metastatic behavior of human tumor cells in mice with species-specific polymerase chain reaction: Elevated expression of angiogenesis and bone resorption stimulators by breast cancer in bone metastases
    • 11393785 10.1359/jbmr.2001.16.6.1077
    • van der Pluijm G, Sijmons B, Vloedgraven H et al (2001) Monitoring metastatic behavior of human tumor cells in mice with species-specific polymerase chain reaction: elevated expression of angiogenesis and bone resorption stimulators by breast cancer in bone metastases. J Bone Miner Res 16:1077-1091
    • (2001) J Bone Miner Res , vol.16 , pp. 1077-1091
    • Van Der Pluijm, G.1    Sijmons, B.2    Vloedgraven, H.3
  • 249
    • 67349149693 scopus 로고    scopus 로고
    • Therapeutic concentrations of dasatinib inhibit in vitro osteoclastogenesis
    • 19092851 1:CAS:528:DC%2BD1MXlslCqt70%3D 10.1038/leu.2008.356
    • Vandyke K, Dewar AL, Farrugia AN et al (2009) Therapeutic concentrations of dasatinib inhibit in vitro osteoclastogenesis. Leukemia 23:994-997
    • (2009) Leukemia , vol.23 , pp. 994-997
    • Vandyke, K.1    Dewar, A.L.2    Farrugia, A.N.3
  • 250
    • 9144245854 scopus 로고    scopus 로고
    • Safety and pain palliation of zoledronic acid in patients with breast cancer, prostate cancer, or multiple myeloma who previously received bisphosphonate therapy
    • 15561812 1:CAS:528:DC%2BD2MXhs1yrsw%3D%3D 10.1634/theoncologist.9-6-687
    • Vogel CL, Yanagihara RH, Wood AJ et al (2004) Safety and pain palliation of zoledronic acid in patients with breast cancer, prostate cancer, or multiple myeloma who previously received bisphosphonate therapy. Oncologist 9:687-695
    • (2004) Oncologist , vol.9 , pp. 687-695
    • Vogel, C.L.1    Yanagihara, R.H.2    Wood, A.J.3
  • 251
    • 0028674693 scopus 로고
    • The role of thrombin in tumor cell metastasis
    • 7657523 1:CAS:528:DyaK2MXovF2mt7s%3D
    • Walz DA, Fenton JW (1994) The role of thrombin in tumor cell metastasis. Invasion Metastasis 14:303-308
    • (1994) Invasion Metastasis , vol.14 , pp. 303-308
    • Walz, D.A.1    Fenton, J.W.2
  • 252
    • 79957484310 scopus 로고    scopus 로고
    • Cancer to bone: A fatal attraction
    • 21593787 1:CAS:528:DC%2BC3MXmtlemu7s%3D 10.1038/nrc3055
    • Weilbaecher KN, Guise TA, McCauley LK (2011) Cancer to bone: a fatal attraction. Nat Rev Cancer 11:411-425
    • (2011) Nat Rev Cancer , vol.11 , pp. 411-425
    • Weilbaecher, K.N.1    Guise, T.A.2    McCauley, L.K.3
  • 253
    • 0003527860 scopus 로고
    • WHO WHO Geneva
    • WHO (1986) Cancer pain relief. WHO, Geneva
    • (1986) Cancer Pain Relief
  • 254
    • 59049085396 scopus 로고    scopus 로고
    • Cathepsin K activity-dependent regulation of osteoclast actin ring formation and bone resorption
    • 19028686 1:CAS:528:DC%2BD1MXlvFegsg%3D%3D 10.1074/jbc.M805280200
    • Wilson SR, Peters C, Saftig P et al (2009) Cathepsin K activity-dependent regulation of osteoclast actin ring formation and bone resorption. J Biol Chem 284:2584-2592
    • (2009) J Biol Chem , vol.284 , pp. 2584-2592
    • Wilson, S.R.1    Peters, C.2    Saftig, P.3
  • 255
    • 77950117427 scopus 로고    scopus 로고
    • Bisphosphonates for the relief of pain secondary to bone metastases
    • Wong R, Wiffen PJ (2002) Bisphosphonates for the relief of pain secondary to bone metastases. Cochrane Database Syst Rev 2:CD002068
    • (2002) Cochrane Database Syst Rev , vol.2
    • Wong, R.1    Wiffen, P.J.2
  • 256
    • 0347928796 scopus 로고    scopus 로고
    • Meta-analysis of dose-fractionation radiotherapy trials for the palliation of painful bone metastases
    • 12573746 10.1016/S0360-3016(02)04147-0
    • Wu JS, Wong R, Johnston M et al (2003) Meta-analysis of dose-fractionation radiotherapy trials for the palliation of painful bone metastases. Int J Radiat Oncol Biol Phys 55:594-605
    • (2003) Int J Radiat Oncol Biol Phys , vol.55 , pp. 594-605
    • Wu, J.S.1    Wong, R.2    Johnston, M.3
  • 257
    • 4344624611 scopus 로고    scopus 로고
    • Prevalent expression of the immunostimulatory MHC class i chain-related molecule is counteracted by shedding in prostate cancer
    • 15314693 1:CAS:528:DC%2BD2cXmvVelsrk%3D
    • Wu JD, Higgins LM, Steinle A et al (2004) Prevalent expression of the immunostimulatory MHC class I chain-related molecule is counteracted by shedding in prostate cancer. J Clin Invest 114:560-568
    • (2004) J Clin Invest , vol.114 , pp. 560-568
    • Wu, J.D.1    Higgins, L.M.2    Steinle, A.3
  • 258
    • 77954163522 scopus 로고    scopus 로고
    • Bone cancer induces a unique central sensitization through synaptic changes in a wide area of the spinal cord
    • 20602757 10.1186/1744-8069-6-38 1:CAS:528:DC%2BC3cXos12lsrs%3D
    • Yanagisawa Y, Furue H, Kawamata T et al (2010) Bone cancer induces a unique central sensitization through synaptic changes in a wide area of the spinal cord. Mol Pain 6:38
    • (2010) Mol Pain , vol.6 , pp. 38
    • Yanagisawa, Y.1    Furue, H.2    Kawamata, T.3
  • 259
    • 34548066096 scopus 로고    scopus 로고
    • Bone metastasis in prostate cancer: Molecular and cellular mechanisms (review)
    • 17549396 1:CAS:528:DC%2BD2sXot1KqtL0%3D
    • Ye L, Kynaston HG, Jiang WG (2007) Bone metastasis in prostate cancer: molecular and cellular mechanisms (review). Int J Mol Med 20:103-111
    • (2007) Int J Mol Med , vol.20 , pp. 103-111
    • Ye, L.1    Kynaston, H.G.2    Jiang, W.G.3
  • 260
    • 33644965593 scopus 로고    scopus 로고
    • Sympathetic sprouting and changes in nociceptive sensory innervation in the glabrous skin of the rat hind paw following partial peripheral nerve injury
    • 16506190 10.1002/cne.20899
    • Yen LD, Bennett GJ, Ribeiro-da-Silva A (2006) Sympathetic sprouting and changes in nociceptive sensory innervation in the glabrous skin of the rat hind paw following partial peripheral nerve injury. J Comp Neurol 495:679-690
    • (2006) J Comp Neurol , vol.495 , pp. 679-690
    • Yen, L.D.1    Bennett, G.J.2    Ribeiro-Da-Silva, A.3
  • 261
    • 0036468926 scopus 로고    scopus 로고
    • Tumor-derived platelet-derived growth factor-BB plays a critical role in osteosclerotic bone metastasis in an animal model of human breast cancer
    • 11830552 1:CAS:528:DC%2BD38Xht1KqsrY%3D
    • Yi B, Williams PJ, Niewolna M et al (2002) Tumor-derived platelet-derived growth factor-BB plays a critical role in osteosclerotic bone metastasis in an animal model of human breast cancer. Cancer Res 62:917-923
    • (2002) Cancer Res , vol.62 , pp. 917-923
    • Yi, B.1    Williams, P.J.2    Niewolna, M.3
  • 262
    • 0030927205 scopus 로고    scopus 로고
    • Inhibition of osteolytic bone metastasis of breast cancer by combined treatment with the bisphosphonate ibandronate and tissue inhibitor of the matrix metalloproteinase-2
    • 9153295 1:CAS:528:DyaK2sXjsVGqt7s%3D 10.1172/JCI119435
    • Yoneda T, Sasaki A, Dunstan C et al (1997) Inhibition of osteolytic bone metastasis of breast cancer by combined treatment with the bisphosphonate ibandronate and tissue inhibitor of the matrix metalloproteinase-2. J Clin Invest 99:2509-2517
    • (1997) J Clin Invest , vol.99 , pp. 2509-2517
    • Yoneda, T.1    Sasaki, A.2    Dunstan, C.3
  • 263
    • 73149115110 scopus 로고    scopus 로고
    • Phase II Study of dasatinib in patients with metastatic castration-resistant prostate cancer
    • 19920114 1:CAS:528:DC%2BD1MXhsFSnu7vO 10.1158/1078-0432.CCR-09-1691
    • Yu E, Wilding G, Posadas E et al (2009) Phase II Study of dasatinib in patients with metastatic castration-resistant prostate cancer. Clin Cancer Res 15:7421-7428
    • (2009) Clin Cancer Res , vol.15 , pp. 7421-7428
    • Yu, E.1    Wilding, G.2    Posadas, E.3
  • 264
    • 79955610443 scopus 로고    scopus 로고
    • Once-daily dasatinib: Expansion of phase II study evaluating safety and efficacy of dasatinib in patients with metastatic castration-resistant prostate cancer
    • 21539969 10.1016/j.urology.2011.01.006
    • Yu E, Massard C, Gross ME et al (2011) Once-daily dasatinib: expansion of phase II study evaluating safety and efficacy of dasatinib in patients with metastatic castration-resistant prostate cancer. Urology 77:1166-1171
    • (2011) Urology , vol.77 , pp. 1166-1171
    • Yu, E.1    Massard, C.2    Gross, M.E.3
  • 266
    • 70350609907 scopus 로고    scopus 로고
    • Recent evidence for activity-dependent initiation of sympathetic sprouting and neuropathic pain
    • 18958370 1:CAS:528:DC%2BD1cXhsVyqu7jO
    • Zhang JM, Strong JA (2008) Recent evidence for activity-dependent initiation of sympathetic sprouting and neuropathic pain. Sheng Li Xue Bao 60:617-627
    • (2008) Sheng Li Xue Bao , vol.60 , pp. 617-627
    • Zhang, J.M.1    Strong, J.A.2
  • 267
    • 27644537034 scopus 로고    scopus 로고
    • Spinal glial activation in a new rat model of bone cancer pain produced by prostate cancer cell inoculation of the tibia
    • 16154703 1:CAS:528:DC%2BD2MXhtFOmt7%2FI 10.1016/j.pain.2005.08.001
    • Zhang RX, Liu B, Wang L et al (2005) Spinal glial activation in a new rat model of bone cancer pain produced by prostate cancer cell inoculation of the tibia. Pain 118:125-136
    • (2005) Pain , vol.118 , pp. 125-136
    • Zhang, R.X.1    Liu, B.2    Wang, L.3
  • 268
    • 45849117181 scopus 로고    scopus 로고
    • Interleukin 1beta facilitates bone cancer pain in rats by enhancing NMDA receptor NR-1 subunit phosphorylation
    • 18554806 1:CAS:528:DC%2BD1cXotlKqs7w%3D 10.1016/j.neuroscience.2008.04. 072
    • Zhang RX, Liu B, Li A et al (2008a) Interleukin 1beta facilitates bone cancer pain in rats by enhancing NMDA receptor NR-1 subunit phosphorylation. Neuroscience 154:1533-1538
    • (2008) Neuroscience , vol.154 , pp. 1533-1538
    • Zhang, R.X.1    Liu, B.2    Li, A.3
  • 269
    • 57249111842 scopus 로고    scopus 로고
    • Chemokine CXCL12 and its receptor CXCR4 expression are associated with perineural invasion of prostate cancer
    • 18983683 1:CAS:528:DC%2BD1cXhsFSgu7bE 10.1186/1756-9966-27-62
    • Zhang S, Qi L, Li M et al (2008b) Chemokine CXCL12 and its receptor CXCR4 expression are associated with perineural invasion of prostate cancer. J Exp Clin Cancer Res 27:62
    • (2008) J Exp Clin Cancer Res , vol.27 , pp. 62
    • Zhang, S.1    Qi, L.2    Li, M.3
  • 270
    • 77951224754 scopus 로고    scopus 로고
    • Mechanisms of breast cancer bone metastasis
    • 20006425 1:CAS:528:DC%2BC3cXksFGksbg%3D 10.1016/j.canlet.2009.11.003
    • Zhang Y, Ma B, Fan Q (2010) Mechanisms of breast cancer bone metastasis. Cancer Lett 292:1-7
    • (2010) Cancer Lett , vol.292 , pp. 1-7
    • Zhang, Y.1    Ma, B.2    Fan, Q.3
  • 271
    • 0041464540 scopus 로고    scopus 로고
    • Phase i dose-escalation study of the safety and pharmacokinetics of atrasentan: An endothelin receptor antagonist for refractory prostate cancer
    • 12912943 1:CAS:528:DC%2BD3sXmtF2hsr8%3D
    • Zonnenberg BA, Groenewegen G, Janus TJ et al (2003) Phase I dose-escalation study of the safety and pharmacokinetics of atrasentan: an endothelin receptor antagonist for refractory prostate cancer. Clin Cancer Res 9:2965-2972
    • (2003) Clin Cancer Res , vol.9 , pp. 2965-2972
    • Zonnenberg, B.A.1    Groenewegen, G.2    Janus, T.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.