Mechanisms of breast cancer bone metastasis

Cancer Letters

Volumn 292, Issue 1, 2010, Pages 1-7

  Zhang, Yunfei ^a   Ma, Baoan ^a   Fan, Qingyu ^a  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Bone metastasis; IGF; PTH rP; TGF; Vicious cycle

Indexed keywords

CADHERIN; CADHERIN 11; CALCIUM SENSING RECEPTOR; CHEMOKINE RECEPTOR CXCR4; INTEGRIN; MATRIX METALLOPROTEINASE; NERVE CELL ADHESION MOLECULE; OSTEOCLAST DIFFERENTIATION FACTOR; PARATHYROID HORMONE RELATED PROTEIN; PHOSPHATE; RECEPTOR ACTIVATOR OF NUCLEAR FACTOR KAPPA B; SODIUM PHOSPHATE COTRANSPORTER; SOMATOMEDIN C; SOMATOMEDIN C RECEPTOR; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR; UNCLASSIFIED DRUG; UVOMORULIN; VITRONECTIN RECEPTOR;

APOPTOSIS; BONE DESTRUCTION; BONE METASTASIS; BREAST CANCER; CANCER INVASION; CANCER RELAPSE; CELL PROLIFERATION; CELL SURVIVAL; CYTOKINE PRODUCTION; EXTRACELLULAR MATRIX; HUMAN; NONHUMAN; OSTEOLYSIS; PRIORITY JOURNAL; SHORT SURVEY; BONE TUMOR; BREAST TUMOR; CELL ADHESION; CHEMISTRY; FEMALE; METABOLISM; METASTASIS; PATHOLOGY; PHYSIOLOGY; REVIEW;

BONE NEOPLASMS; BREAST NEOPLASMS; CADHERINS; CELL ADHESION; FEMALE; HUMANS; INSULIN-LIKE GROWTH FACTOR I; NEOPLASM INVASIVENESS; PARATHYROID HORMONE-RELATED PROTEIN; TRANSFORMING GROWTH FACTOR BETA;

EID: 77951224754     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.canlet.2009.11.003     Document Type: Review

References (61)

1. Coleman R.E., Rubens R.D. The clinical course of bone metastases from breast cancer. Br .J. Cancer 1987, 55(1):61-66.
2. Coleman R.E., Seaman J.J. The role of zoledronic acid in cancer: clinical studies in the treatment and prevention of bone metastases. Semin. Oncol. 2001, 28(2 Suppl. 6):11-16.
3. Charhon S.A., Chapuy M.C., Delvin E.E., Valentin-Opran A., Edouard C.M., Meunier P.J. Histomorphometric analysis of sclerotic bone metastases from prostatic carcinoma special reference to osteomalacia. Cancer 1983, 51(5):918-924.
4. Oades G.M., Coxon J., Colston K.W. The potential role of bisphosphonates in prostate cancer. Prostate Cancer Prostatic Dis. 2002, 5(4):264-272.
5. Rusciano D., Burger M.M. Why do cancer cells metastasize into particular organs?. Bioessays 1992, 14(3):185-194.
6. Ruoslahti E. How cancer spreads. Sci. Am. 1996, 275(3):72-77.
7. Coleman R.E. Skeletal complications of malignancy. Proceedings of a symposium. Bethesda, Maryland, April 19-20, 1997. Cancer 1997, 80(8 Suppl):1527-1701.
8. Paget S. The distribution of secondary growths in cancer of the breast, 1889. Cancer Metast. Rev. 1989, 8(2):98-101.
9. Liotta L.A., Kohn E.C. The microenvironment of the tumour-host interface. Nature 2001, 411(6835):375-379.
10. Fidler I.J. Critical determinants of metastasis. Semin. Cancer Biol. 2002, 12(2):89-96.
11. Kahn D., Weiner G.J., Ben-Haim S., Ponto L.L., Madsen M.T., Bushnell D.L., Watkins G.L., Argenyi E.A., Hichwa R.D. Positron emission tomographic measurement of bone marrow blood flow to the pelvis and lumbar vertebrae in young normal adults. Blood 1994, 83(4):958-963.
12. Hauschka P.V., Mavrakos A.E., Iafrati M.D., Doleman S.E., Klagsbrun M. Growth factors in bone matrix. Isolation of multiple types by affinity chromatography on heparin-sepharose. J. Biol. Chem. 1986, 261(27):12665-12674.
13. Pfeilschifter J., Mundy G.R. Modulation of type beta transforming growth factor activity in bone cultures by osteotropic hormones. Proc. Natl. Acad. Sci. USA 1987, 84(7):2024-2028.
14. Kowalski P.J., Rubin M.A., Kleer C.G. E-cadherin expression in primary carcinomas of the breast and its distant metastases. Breast Cancer Res. 2003, 5(6):R217-R222.
15. Berx G., Van Roy F. The E-cadherin/catenin complex: an important gatekeeper in breast cancer tumorigenesis and malignant progression. Breast Cancer Res. 2001, 3(5):289-293.
16. Mareel M., Boterberg T., Noe V., Van Hoorde L., Vermeulen S., Bruyneel E., Bracke M. E-cadherin/catenin/cytoskeleton complex: a regulator of cancer invasion. J. Cell. Physiol. 1997, 173(2):271-274.
17. Mbalaviele G., Dunstan C.R., Sasaki A., Williams P.J., Mundy G.R., Yoneda T. E-cadherin expression in human breast cancer cells suppresses the development of osteolytic bone metastases in an experimental metastasis model. Cancer Res. 1996, 56(17):4063-4070.
18. Hazan R.B., Phillips G.R., Qiao R.F., Norton L., Aaronson S.A. Exogenous expression of N-cadherin in breast cancer cells induces cell migration, invasion, and metastasis. J. Cell Biol. 2000, 148(4):779-790.
19. Suyama K., Shapiro I., Guttman M., Hazan R.B. A signaling pathway leading to metastasis is controlled by N-cadherin and the FGF receptor. Cancer Cell. 2002, 2(4):301-314.
20. Feltes C.M., Kudo A., Blaschuk O., Byers S.W. An alternatively spliced cadherin-11 enhances human breast cancer cell invasion. Cancer Res. 2002, 62(22):6688-6697.
21. Chu K., Cheng C.J., Ye X., Lee Y.C., Zurita A.J., Chen D.T., Yu-Lee L.Y., Zhang S., Yeh E.T., Hu M.C., Logothetis C.J., Lin S.H. Cadherin-11 promotes the metastasis of prostate cancer cells to bone. Mol. Cancer Res. 2008, 6(8):1259-1267.
22. Coussens L.M., Fingleton B., Matrisian L.M. Matrix metalloproteinase inhibitors and cancer: trials and tribulations. Science 2002, 295(5564):2387-2392.
23. Chambers A.F., Matrisian L.M. Changing views of the role of matrix metalloproteinases in metastasis. J. Natl. Cancer Inst. 1997, 89(17):1260-1270.
24. Liotta L.A., Tryggvason K., Garbisa S., Hart I., Foltz C.M., Shafie S. Metastatic potential correlates with enzymatic degradation of basement membrane collagen. Nature 1980, 284(5751):67-68.
25. Liotta L.A. Tumor invasion and metastases - role of the extracellular matrix: Rhoads Memorial Award lecture. Cancer Res. 1986, 46(1):1-7.
26. Olszynski K., Zimowska M. Structure and function of matrix metalloproteinases. Postepy Biochem. 2009, 55(1):76-84.
27. Deryugina E.I., Quigley J.P. Matrix metalloproteinases and tumor metastasis. Cancer Metast. Rev. 2006, 25(1):9-34.
28. Ueda J., Kajita M., Suenaga N., Fujii K., Seiki M. Sequence-specific silencing of MT1-MMP expression suppresses tumor cell migration and invasion: importance of MT1-MMP as a therapeutic target for invasive tumors. Oncogene 2003, 22(54):8716-8722.
29. Fingleton B. Matrix metalloproteinases: roles in cancer and metastasis. Front. Biosci. 2006, 11:479-491.
30. Agarwal D., Goodison S., Nicholson B., Tarin D., Urquidi V. Expression of matrix metalloproteinase 8 (MMP-8) and tyrosinase-related protein-1 (TYRP-1) correlates with the absence of metastasis in an isogenic human breast cancer model. Differentiation 2003, 71(2):114-125.
31. Montel V., Kleeman J., Agarwal D., Spinella D., Kawai K., Tarin D. Altered metastatic behavior of human breast cancer cells after experimental manipulation of matrix metalloproteinase 8 gene expression. Cancer Res. 2004, 64(5):1687-1694.
32. Chen J., Baskerville C., Han Q., Pan Z.K., Huang S. Alpha(v) integrin, p38 mitogen-activated protein kinase, and urokinase plasminogen activator are functionally linked in invasive breast cancer cells. J. Biol. Chem. 2001, 276(51):47901-47905.
33. Deryugina E.I., Bourdon M.A., Jungwirth K., Smith J.W., Strongin A.Y. Functional activation of integrin alpha V beta 3 in tumor cells expressing membrane-type 1 matrix metalloproteinase. Int. J. Cancer 2000, 86(1):15-23.
34. Zlotnik A., Yoshie O. Chemokines: a new classification system and their role in immunity. Immunity 2000, 12(2):121-127.
35. Campbell J.J., Butcher E.C. Chemokines in tissue-specific and microenvironment-specific lymphocyte homing. Curr. Opin. Immunol. 2000, 12(3):336-341.
36. Singh D., Joshi D.D., Hameed M., Qian J., Gascon P., Maloof P.B., Mosenthal A., Rameshwar P. Increased expression of preprotachykinin-I and neurokinin receptors in human breast cancer cells: implications for bone marrow metastasis. Proc. Natl. Acad. Sci. USA 2000, 97(1):388-393.
37. Muller A., Homey B., Soto H., Ge N., Catron D., Buchanan M.E., McClanahan T., Murphy E., Yuan W., Wagner S.N., Barrera J.L., Mohar A., Verastegui E., Zlotnik A. Involvement of chemokine receptors in breast cancer metastasis. Nature 2001, 410(6824):50-56.
38. Peled A., Petit I., Kollet O., Magid M., Ponomaryov T., Byk T., Nagler A., Ben-Hur H., Many A., Shultz L., Lider O., Alon R., Zipori D., Lapidot T. Dependence of human stem cell engraftment and repopulation of NOD/SCID mice on CXCR4. Science 1999, 283(5403):845-848.
39. Sloan E.K., Anderson R.L. Genes involved in breast cancer metastasis to bone. Cell. Mol. Life Sci. 2002, 59(9):1491-1502.
40. Smith M.C., Luker K.E., Garbow J.R., Prior J.L., Jackson E., Piwnica-Worms D., Luker G.D. CXCR4 regulates growth of both primary and metastatic breast cancer. Cancer Res. 2004, 64(23):8604-8612.
41. Liang Z., Yoon Y., Votaw J., Goodman M.M., Williams L., Shim H. Silencing of CXCR4 blocks breast cancer metastasis. Cancer Res. 2005, 65(3):967-971.
42. Kang Y., Siegel P.M., Shu W., Drobnjak M., Kakonen S.M., Cordon-Cardo C., Guise T.A., Massague J. A multigenic program mediating breast cancer metastasis to bone. Cancer Cell. 2003, 3(6):537-549.
43. van der P., Vloedgraven H., Papapoulos S., Lowick C., Grzesik W., Kerr J., Robey P.G. Attachment characteristics and involvement of integrins in adhesion of breast cancer cell lines to extracellular bone matrix components. Lab. Invest. 1997, 77(6):665-675.
44. Sung V., Stubbs J.T., Fisher L., Aaron A.D., Thompson E.W. Bone sialoprotein supports breast cancer cell adhesion proliferation and migration through differential usage of the alpha(v)beta3 and alpha(v)beta5 integrins. J. Cell. Physiol. 1998, 176(3):482-494.
45. Pecheur I., Peyruchaud O., Serre C.M., Guglielmi J., Voland C., Bourre F., Margue C., Cohen-Solal M., Buffet A., Kieffer N., Clezardin P. Integrin alpha(v)beta3 expression confers on tumor cells a greater propensity to metastasize to bone. FASEB J. 2002, 16(10):1266-1268.
46. Harms J.F., Welch D.R., Samant R.S., Shevde L.A., Miele M.E., Babu G.R., Goldberg S.F., Gilman V.R., Sosnowski D.M., Campo D.A., Gay C.V., Budgeon L.R., Mercer R., Jewell J., Mastro A.M., Donahue H.J., Erin N., Debies M.T., Meehan W.J., Jones A.L., Mbalaviele G., Nickols A., Christensen N.D., Melly R., Beck L.N., Kent J., Rader R.K., Kotyk J.J., Pagel M.D., Westlin W.F., Griggs D.W. A small molecule antagonist of the alpha(v)beta3 integrin suppresses MDA-MB-435 skeletal metastasis. Clin. Exp. Metast. 2004, 21(2):119-128.
47. Okazaki M., Takeshita S., Kawai S., Kikuno R., Tsujimura A., Kudo A., Amann E. Molecular cloning and characterization of OB-cadherin, a new member of cadherin family expressed in osteoblasts. J. Biol. Chem. 1994, 269(16):12092-12098.
48. Tamura D., Hiraga T., Myoui A., Yoshikawa H., Yoneda T. Cadherin-11-mediated interactions with bone marrow stromal/osteoblastic cells support selective colonization of breast cancer cells in bone. Int. J. Oncol. 2008, 33(1):17-24.
49. Ramaswamy S., Ross K.N., Lander E.S., Golub T.R. A molecular signature of metastasis in primary solid tumors. Nat. Genet. 2003, 33(1):49-54.
50. Yoneda T., Hiraga T. Crosstalk between cancer cells and bone microenvironment in bone metastasis. Biochem. Biophys. Res. Commun. 2005, 328(3):679-687.
51. Kronenberg H.M. NPT2a - the key to phosphate homeostasis. New Engl. J. Med. 2002, 347(13):1022-1024.
52. Taube T., Elomaa I., Blomqvist C., Beneton M.N., Kanis J.A. Histomorphometric evidence for osteoclast-mediated bone resorption in metastatic breast cancer. Bone 1994, 15(2):161-166.
53. Boyde A., Maconnachie E., Reid S.A., Delling G., Mundy G.R. Scanning electron microscopy in bone pathology: review of methods, potential and applications. Scan. Electron Micros. (Pt 4) 1986, 1537-1554.
54. Mundy G.R. Metastasis to bone: causes, consequences and therapeutic opportunities. Nat. Rev. Cancer 2002, 2(8):584-593.
55. Roodman G.D. Mechanisms of bone metastasis. New Engl. J. Med. 2004, 350(16):1655-1664.
56. Powell G.J., Southby J., Danks J.A., Stillwell R.G., Hayman J.A., Henderson M.A., Bennett R.C., Martin T.J. Localization of parathyroid hormone-related protein in breast cancer metastases: increased incidence in bone compared with other sites. Cancer Res. 1991, 51(11):3059-3061.
57. Vargas S.J., Gillespie M.T., Powell G.J., Southby J., Danks J.A., Moseley J.M., Martin T.J. Localization of parathyroid hormone-related protein mRNA expression in breast cancer and metastatic lesions by in situ hybridization. J. Bone Miner. Res. 1992, 7(8):971-979.
58. Kohno N., Kitazawa S., Fukase M., Sakoda Y., Kanbara Y., Furuya Y., Ohashi O., Ishikawa Y., Saitoh Y. The expression of parathyroid hormone-related protein in human breast cancer with skeletal metastases. Surg. Today. 1994, 24(3):215-220.
59. Suda T., Takahashi N., Udagawa N., Jimi E., Gillespie M.T., Martin T.J. Modulation of osteoclast differentiation and function by the new members of the tumor necrosis factor receptor and ligand families. Endocr. Rev. 1999, 20(3):345-357.
60. Thomas R.J., Guise T.A., Yin J.J., Elliott J., Horwood N.J., Martin T.J., Gillespie M.T. Breast cancer cells interact with osteoblasts to support osteoclast formation. Endocrinology 1999, 140(10):4451-4458.
61. Sanders J.L., Chattopadhyay N., Kifor O., Yamaguchi T., Brown E.M. Extracellular calcium-sensing receptor (CaR) expression and its potential role in parathyroid hormone-related peptide (PTHrP) secretion in the H-500 rat Leydig cell model of humoral hypercalcemia of malignancy. Biochem. Biophys. Res. Commun. 2000, 269(2):427-432.