Blocking caspase activity prevents transsynaptic neuronal apoptosis and the loss of inhibition in lamina II of the dorsal horn after peripheral nerve injury

Journal of Neuroscience

Volumn 25, Issue 32, 2005, Pages 7317-7323

  Scholz, Joachim ^a   Broom, Daniel C ^a   Youn, Dong Ho ^a   Mills, Charles D ^a   Kohno, Tatsuro ^a   Suter, Marc R ^b   Moore, Kimberly A ^a   Decosterd, Isabelle ^b   Coggeshall, Richard E ^c   Woolf, Clifford J ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

^c University of Texas Medical Branch School of Medicine   (United States)

Author keywords

Caspase 3; Dorsal horn; GABA; Glutamate excitotoxicity; Neuropathic pain; Spinal inhibition

Indexed keywords

4 AMINOBUTYRIC ACID; BENZYLOXYCARBONYLVALYLALANYLASPARTYL FLUOROMETHYL KETONE; BISBENZIMIDE; CASPASE; CASPASE 3; CASPASE INHIBITOR; GLUTAMATE RECEPTOR; HOE 33342;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CELL LOSS; CONTROLLED STUDY; ENZYME ACTIVITY; GABAERGIC TRANSMISSION; HYPERSENSITIVITY; MALE; NERVE LIGATION; NEUROPATHIC PAIN; NONHUMAN; PERIPHERAL NERVE INJURY; PRIORITY JOURNAL; RAT; SPINAL CORD DORSAL HORN; SPINAL NERVE; STEREOLOGY; SYNAPTIC TRANSMISSION;

AFFERENT PATHWAYS; AMINO ACID CHLOROMETHYL KETONES; ANIMALS; APOPTOSIS; BEHAVIOR, ANIMAL; CASPASES; ENZYME INHIBITORS; MALE; NEURAL INHIBITION; NEURALGIA; NEURONS; POSTERIOR HORN CELLS; RATS; RATS, SPRAGUE-DAWLEY; SCIATIC NERVE; SPINAL CORD; SYNAPSES; WOUNDS AND INJURIES;

EID: 23744437312     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.1526-05.2005     Document Type: Article

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