Enlargement of the receptive field size to low intensity mechanical stimulation in the rat spinal nerve ligation model of neuropathy

Experimental Neurology

Volumn 163, Issue 2, 2000, Pages 408-413

  Suzuki, Rie ^a   Kontinen, Vesa K ^a   Matthews, Elizabeth ^a   Williams, Emma ^a   Dickenson, Anthony H ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Animal models; Dorsal horn of the spinal cord; Mechanical allodynia; Neuropathic pain; Sensory receptive field

Indexed keywords

ALLODYNIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; EVOKED RESPONSE; EXCITATION CONTRACTION COUPLING; MECHANICAL STIMULATION; NERVE INJURY; NERVE LIGATION; NERVE STIMULATION; NEUROPATHY; NONHUMAN; PERIPHERAL NERVE; PRIORITY JOURNAL; RAT; RECEPTIVE FIELD; SENSORY RECEPTOR; SPINAL CORD DORSAL HORN; SPINAL NERVE;

EID: 0034125842     PISSN: 00144886     EISSN: None     Source Type: Journal    
DOI: 10.1006/exnr.2000.7371     Document Type: Article

References (36)

1. Behbehani M. M., Dollberg-Stolik O. Partial sciatic nerve ligation results in an enlargement of the receptive field and enhancement of the response of dorsal horn neurons to noxious stimulation by an adenosine agonist. Pain. 58:1994;421-428.
2. Bennett G. J., Xie Y. K. A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man. Pain. 33:1988;87-107.
3. Besse D., Lombard M. C., Besson J. M. The distribution of mu and delta opioid binding sites belonging to a single cervical dorsal root in the superficial dorsal horn of the rat spinal cord: A quantitative autoradiographic study. Eur. J. Neurosci. 3:1991;1343-1352.
4. Billy A. J., Walters E. T. Long-term expansion and sensitization of mechanosensory receptive fields in Aplysia support an activity-dependent model of whole-cell sensory plasticity. J. Neurosci. 9:1989;1254-1262.
5. Brenowitz G. L. Timecourse for receptive field plasticity following spinal cord hemisection. Brain Res. 279:1983;250-253.
6. Brenowitz G. L., Pubols L. M. Increased receptive field size of dorsal horn neurons following chronic spinal cord hemisections in cats. Brain Res. 216:1981;45-59.
7. Chapman V., Suzuki R., Chamarette H. L., Rygh L. J., Dickenson A. H. Effects of systemic carbamazepine and gabapentin on spinal neuronal responses in spinal nerve ligated rats. Pain. 75:1998;261-272.
8. Chapman V., Suzuki R., Dickenson A. H. Electrophysiological characterization of spinal neuronal response properties in anaesthetized rats after ligation of spinal nerves L5-L6. J. Physiol. 507:1998;881-894.
9. Cumberbatch M. J., Carlson E., Wyatt A., Boyce S., Hill R. G., Rupniak N. M. Reversal of behavioural and electrophysiological correlates of experimental peripheral neuropathy by the NK1 receptor antagonist GR205171 in rats. Neuropharmacology. 37:1998;1535-1543.
10. Devor M., Wall P. D. Plasticity in the spinal cord sensory map following peripheral nerve injury in rats. J. Neurosci. 1:1981;679-684.
11. Dickenson A. Mechanisms of central hypersensitivity: Excitatory amino acid mechanisms and their control. Dickenson A., Besson J.-M. The pharmacology of Pain. 1997;167-210 Springer, Berlin.
12. Dickenson A. H., Sullivan A. F. Electrophysiological studies on the effects of intrathecal morphine on nociceptive neurones in the rat dorsal horn. Pain. 24:1986;211-222.
13. Dubner R., Sharav Y., Gracely R. H., Price D. D. Idiopathic trigeminal neuralgia: sensory features and pain mechanisms. Pain. 31:1987;23-33.
14. Eblen-Zajjur A. A., Sandkuhler J. Synchronicity of nociceptive and non-nociceptive adjacent neurons in the spinal dorsal horn of the rat: Stimulus-induced plasticity. Neuroscience. 76:1997;39-54.
15. Grubb B. D., Stiller R. U., Schaible H. G. Dynamic changes in the receptive field properties of spinal cord neurons with ankle input in rats with chronic unilateral inflammation in the ankle region. Exp. Brain Res. 92:1993;441-452.
16. Headley M., Chizh B. A., Herreo J. F., Hartell N. A. Electrophysiology of spinal sensory processing in the absence and presence of anaesthesia. Lydic R., Baghdoyan H. A. Handbook of Behavioural State Control: Cellular and Molecular Mechanisms. 1999;CRC Press, Boca Raton.
17. Hylden J. L., Nahin R. L., Traub R. J., Dubner R. Expansion of receptive fields of spinal lamina I projection neurons in rats with unilateral adjuvant-induced inflammation: The contribution of dorsal horn mechanisms. Pain. 37:1989;229-243.
18. Hylden J. L., Nahin R. L., Traub R. J., Dubner R. Expansion of receptive fields of spinal lamina I projection neurons in rats with unilateral adjuvant-induced inflammation: The contribution of dorsal horn mechanisms. Exp. Brain Res. 79:1990;283-292.
19. Kajander K. C., Bennett G. J. Onset of a painful peripheral neuropathy in rat: A partial and differential deafferentation and spontaneous discharge in A beta and A delta primary afferent neurons. J. Neurophysiol. 68:1992;734-744.
20. Kim S. H., Chung J. M. An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat. Pain. 50:1992;355-363.
21. Kontinen V. K., Paananen S., Kalso E. The effects of the alpha2-adrenergic agonist, dexmedetomidine, in the spinal nerve ligation model of neuropathic pain in rats. Anesthesia Analgesia. 86:1998;355-360.
22. Kontinen V. K., Paananen S., Kalso E. Systemic morphine in the prevention of allodynia in the rat spinal nerve ligation model of neuropathic pain. Eur. J. Pain. 2:1998;35-42.
23. Laird J. M., Bennett G. J. An electrophysiological study of dorsal horn neurons in the spinal cord of rats with an experimental peripheral neuropathy. J. Neurophysiol. 69:1993;2072-2085.
24. Laird J. M., Cervero F. A comparative study of the changes in receptive-field properties of multireceptive and nocireceptive rat dorsal horn neurons following noxious mechanical stimulation. J. Neurophysiol. 62:1989;854-863.
25. Luukko M., Konttinen Y., Kemppinen P., Pertovaara A. Influence of various experimental parameters on the incidence of thermal and mechanical hyperalgesia induced by a constriction mononeuropathy of the sciatic nerve in lightly anesthetized rats. Exp. Neurol. 128:1994;143-154.
26. Maves T. J., Pechman P. S., Gebhart G. F., Meller S. T. Possible chemical contribution from chromic gut sutures produces disorders of pain sensation like those seen in man. Pain. 54:1993;57-69.
27. Palecek J., Dougherty P. M., Kim S. H., Paleckova V., Lekan H., Chung J. M., Carlton S. M., Willis W. D. Responses of spinothalamic tract neurons to mechanical and thermal stimuli in an experimental model of peripheral neuropathy in primates. J. Neurophysiol. 68:1992;1951-1966.
28. Palecek J., Paleckova V., Dougherty P. M., Carlton S. M., Willis W. D. Responses of spinothalamic tract cells to mechanical and thermal stimulation of skin in rats with experimental peripheral neuropathy. J. Neurophysiol. 67:1992;1562-1573.
29. Pertovaara A., Kontinen V. K., Kalso E. Chronic spinal nerve ligation induces changes in response characteristics of nociceptive spinal dorsal horn neurons and in their descending regulation originating in the periaqueductal gray in the rat. Exp. Neurol. 147:1997;428-436.
30. Seltzer Z., Dubner R., Shir Y. A novel behavioral model of neuropathic pain disorders produced in rats by partial sciatic nerve injury. Pain. 43:1990;205-218.
31. Takaishi K., Eisele J. H. Jr., Carstens E. Behavioral and electrophysiological assessment of hyperalgesia and changes in dorsal horn responses following partial sciatic nerve ligation in rats. Pain. 66:1996;297-306.
32. Thalhammer J. G., LaMotte R. H. Spatial properties of nociceptor sensitization following heat injury of the skin. Brain Res. 231:1982;257-265.
33. Tong Y. G., Wang H. F., Ju G., Grant G., Hokfelt T., Zhang X. Increased uptake and transport of cholera toxin B-subunit in dorsal root ganglion neurons after peripheral axotomy: Possible implications for sensory sprouting. J. Comp. Neurol. 404:1999;143-158.
34. Woolf C. J., Shortland P., Coggeshall R. E. Peripheral nerve injury triggers central sprouting of myelinated afferents. Nature. 355:1992;75-78.
35. Woolf C. J., Shortland P., Sivilotti L. G. Sensitization of high mechanothreshold superficial dorsal horn and flexor motor neurones following chemosensitive primary afferent activation. Pain. 58:1994;141-155.
36. Zimmerman M. Ethical guidelines for investigation of experimental pain in conscious animals. Pain. 16:1983;109-110.