Pain affect encoded in human anterior cingulate but not somatosensory cortex

Science

Volumn 277, Issue 5328, 1997, Pages 968-971

  Rainville, Pierre ^a   Duncan, Gary H ^a   Price, Donald D ^a   Carrier, Benoît ^a   Bushnell, M Catherine ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

WATER O 15;

ARTICLE; BRAIN BLOOD FLOW; CINGULATE GYRUS; CONTROLLED STUDY; HUMAN; HYPNOSIS; NOCICEPTIVE STIMULATION; PAIN ASSESSMENT; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; SOMATOSENSORY CORTEX;

ADULT; AFFECT; BRAIN MAPPING; FEMALE; FRONTAL LOBE; GYRUS CINGULI; HUMANS; HYPNOSIS; MALE; MIDDLE AGED; PAIN; PAIN MEASUREMENT; REGIONAL BLOOD FLOW; REGRESSION ANALYSIS; SOMATOSENSORY CORTEX; TEMPERATURE SENSE; TOMOGRAPHY, EMISSION-COMPUTED;

EID: 0030825636     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.277.5328.968     Document Type: Article

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19. Suggestions for increased and decreased unpleasantness were adapted from B. D. Kiernan, J. R. Dane, L. H. Phillips, D. D. Price, Pain 60, 39 (1995), validated for separating sensory and affective pain perception [B. Carrier, P. Rainville, G. H. Duncan, M. C. Bushnell, in abstracts of the Eighth World Congress on Pain, International Association for the Study of Pain, Vancouver, British Columbia, Canada, 17 to 22 August 1996 (IASP Press, Seattle, WA, 1996), abstr. 132, p. 478], and confirmed in the individuals chosen for these imaging experiments.
20. Suggestions for increased and decreased unpleasantness were adapted from B. D. Kiernan, J. R. Dane, L. H. Phillips, D. D. Price, Pain 60, 39 (1995), validated for separating sensory and affective pain perception [B. Carrier, P. Rainville, G. H. Duncan, M. C. Bushnell, in abstracts of the Eighth World Congress on Pain, International Association for the Study of Pain, Vancouver, British Columbia, Canada, 17 to 22 August 1996 (IASP Press, Seattle, WA, 1996), abstr. 132, p. 478], and confirmed in the individuals chosen for these imaging experiments.
21. A preliminary report has appeared as an abstract [P. Rainville, G. H. Duncan, D. D. Price, M. C. Bushnell, Soc. Neurosci. Abstr. 22, 117 (1996)].
22. Before the experiment a group of volunteers were tested with the noxious stimuli and hypnotic induction and suggestion procedures. From that group three female and five male participants, 19 to 53 years in age, who displayed moderate to high hypnotic suggestibility (Standford Suggestibility Scale Form A) and robust modulation of pain unpleasantness were chosen fo the PET study. Experimental sessions (12 scans) were administered once to each of five participants and twice to three other particinants. Because of possible residual effects of hypnotic suggestions, the alert control conditions were always presented first, followed by hypnotic control (without suggestions of altered perception), and finally suggestions for increased (↑UNP) of decreased (↓UNP) unpleasantness. "Neutral" (35°C) and "painfully hot" (46.5° to 47.5°C) stimuli were counterbalanced across individuals within the alert and hypnotic control states, as were the blocks of two ↑UNP and two ↓UNP scans.
23. This 75-s hand immersion stimulus was was chosen on the basis of our previous findings that tonic pain has a stronger affective component than phasic pain [P. Rainvilli, J. S. Feine, M. C. Bushnell, G. H. Duncan, Somatosens. Mot. Res. 9, 265 (1992)]. Temperatures were adjusted individually to obtain pain ratings of 40 to 80 on a scale of 0 to 100 [see (11)]; resulting temperatures ranged from 46.5° to 47.5°C.
24. Participants rated pain intensity and unpleasantness using separate numerical scales of 0 to 100. The intensity scale endpoints were "no burning, pricking, stinging sensation" the most frequently chosen words describing the sensory aspect of heat pain in an independent study [C. Morin, L. TenBokum, M. C. Bushnell, Soc. Neurosci. Abstr. 20, 127 (1994)], and "extremely intense sensation." The unpleasantness scale endpoints were "not at all unpleasant" and "extremely unpleasant." To avoid ceiling effects, we instructed participants that responses could surpass 100 if larger values were needed to describe sensations relative to those previously rated.
25. 15O. Scans began 15 s after the injection, and data were collected in two sequential frames of 40 and 20 s (data presented are derived from the 40-s frame, which yield the better signal-to-noise ratio). Scans were separated by 12 to 15 min to allow tracer decay to background levels.
26. MRI scans (160 contiguous 1-mm-thick slices) were acquired on a Philips 1.5T Gyroscan system. Each participant's PET and MRI volumes were transformed into the Talairach coordinate system [J. Talairach and P. Tournoux, Co-Planar Stereotexic Atlas of the Human Brain (Thième, New York, 1988) ] by using the automated methods of D. L. Collins, P. Neelin, T. M. Peters, and A. C. Evans, [J. Comput. Assisted Tomogr, 18, 192 (1994)]. PET and MRI volumes were resampled to obtain voxels of 1.34 mm by 1.72 mm by 1.50 mm in the x, y, and z planes, respectively.
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