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Volumn 15, Issue 1, 2010, Pages 27-40

Anti-endothelin drugs in solid tumors

Author keywords

Atrasentan; Endothelins; Prostate cancer; Zibotentan

Indexed keywords

ATRASENTAN; BOSENTAN; ENDOTHELIN; ENDOTHELIN RECEPTOR; N (3 METHOXY 5 METHYL 2 PYRAZINYL) 2 [4 (1,3,4 OXADIAZOL 2 YL)PHENYL] 3 PYRIDINESULFONAMIDE; PLACEBO; UNCLASSIFIED DRUG; ZIBOTENTAN;

EID: 77749261162     PISSN: 14728214     EISSN: None     Source Type: Journal    
DOI: 10.1517/14728210903571667     Document Type: Review
Times cited : (19)

References (83)
  • 1
    • 0012576401 scopus 로고
    • Primary structure, synthesis, and biological activity of rat endothelin, an endothelium-derived vasoconstrictor peptide
    • Yanagisawa M, Inoue A, Ishikawa T, et al. Primary structure, synthesis, and biological activity of rat endothelin, an endothelium-derived vasoconstrictor peptide. Proc Natl Acad Sci USA 1988;85(18):6964-7
    • (1988) Proc Natl Acad Sci USA , vol.85 , Issue.18 , pp. 6964-6967
    • Yanagisawa, M.1    Inoue, A.2    Ishikawa, T.3
  • 2
    • 1942453322 scopus 로고    scopus 로고
    • Historical review: Endothelin
    • Masaki T. Historical review: endothelin. Trends Pharmacol Sci 2004;25(4):219-24
    • (2004) Trends Pharmacol Sci , vol.25 , Issue.4 , pp. 219-224
    • Masaki, T.1
  • 3
    • 4344625871 scopus 로고    scopus 로고
    • Endothelin receptors as novel targets in tumor therapy
    • Bagnato A, Natali PG. Endothelin receptors as novel targets in tumor therapy. J Transl Med 2004;2(1):16
    • (2004) J Transl Med , vol.2 , Issue.1 , pp. 16
    • Bagnato, A.1    Natali, P.G.2
  • 4
    • 0029116310 scopus 로고
    • Endothelins
    • Levin ER. Endothelins. N Engl J Med 1995;333(6):356-63
    • (1995) N Engl J Med , vol.333 , Issue.6 , pp. 356-363
    • Levin, E.R.1
  • 5
    • 0033659129 scopus 로고    scopus 로고
    • The endothelin family: An overview
    • Masaki T. The endothelin family: an overview. J Cardiovasc Pharmacol 2000;35(4 Suppl 2):S3-5
    • (2000) J Cardiovasc Pharmacol , vol.35 , Issue.4 SUPPL. 2
    • Masaki, T.1
  • 6
    • 0031440109 scopus 로고    scopus 로고
    • Human endothelin-converting enzyme (ECE-1): Three isoforms with distinct subcellular localizations
    • Schweizer A, Valdenaire O, Nelbock P, et al. Human endothelin-converting enzyme (ECE-1): three isoforms with distinct subcellular localizations. Biochem J 1997;328 (Pt 3):871-7
    • (1997) Biochem J , vol.328 , Issue.PART 3 , pp. 871-877
    • Schweizer, A.1    Valdenaire, O.2    Nelbock, P.3
  • 7
    • 0027992642 scopus 로고
    • ECE-1: A membrane-bound metalloprotease that catalyzes the proteolytic activation of big endothelin-1
    • Xu D, Emoto N, Giaid A, et al. ECE-1: a membrane-bound metalloprotease that catalyzes the proteolytic activation of big endothelin-1. Cell 1994;78(3):473-85
    • (1994) Cell , vol.78 , Issue.3 , pp. 473-485
    • Xu, D.1    Emoto, N.2    Giaid, A.3
  • 8
    • 0028154980 scopus 로고
    • Clinical review 53: The endocrinology of vasoactive peptides: synthesis to function
    • Rubin SA, Levin ER. Clinical review 53: The endocrinology of vasoactive peptides: synthesis to function. J Clin Endocrinol Metab 1994;78(1):6-10
    • (1994) J Clin Endocrinol Metab , vol.78 , Issue.1 , pp. 6-10
    • Rubin, S.A.1    Levin, E.R.2
  • 9
    • 0024563798 scopus 로고
    • Specific binding of endothelin on human vascular smooth muscle cells in culture
    • Clozel M, Fischli W, Guilly C. Specific binding of endothelin on human vascular smooth muscle cells in culture. J Clin Invest 1989;83(5):1758-61
    • (1989) J Clin Invest , vol.83 , Issue.5 , pp. 1758-1761
    • Clozel, M.1    Fischli, W.2    Guilly, C.3
  • 10
    • 0026612994 scopus 로고
    • The endothelin ETB receptor mediates both vasodilation and vasoconstriction in vivo
    • Clozel M, Gray GA, Breu V, et al. The endothelin ETB receptor mediates both vasodilation and vasoconstriction in vivo. Biochem Biophys Res Commun 1992;186(2):867-73
    • (1992) Biochem Biophys Res Commun , vol.186 , Issue.2 , pp. 867-873
    • Clozel, M.1    Gray, G.A.2    Breu, V.3
  • 11
    • 0027161460 scopus 로고
    • The endothelin family of peptides: Local hormones with diverse roles in health and disease?
    • Haynes WG, Webb DJ. The endothelin family of peptides: local hormones with diverse roles in health and disease? Clin Sci (Lond) 1993;84(5):485-500
    • (1993) Clin Sci (Lond) , vol.84 , Issue.5 , pp. 485-500
    • Haynes, W.G.1    Webb, D.J.2
  • 13
    • 33749055385 scopus 로고    scopus 로고
    • G-protein-coupled receptors, channels, and Na+-H+ exchanger in nuclear membranes of heart, hepatic, vascular endothelial, and smooth muscle cells
    • Bkaily G, Nader M, Avedanian L, et al. G-protein-coupled receptors, channels, and Na+-H+ exchanger in nuclear membranes of heart, hepatic, vascular endothelial, and smooth muscle cells. Can J Physiol Pharmacol 2006;84(3-4):431-41
    • (2006) Can J Physiol Pharmacol , vol.84 , Issue.3-4 , pp. 431-441
    • Bkaily, G.1    Nader, M.2    Avedanian, L.3
  • 15
    • 0036884694 scopus 로고    scopus 로고
    • New therapeutics that antagonize endothelin: Promises and frustrations
    • Remuzzi G, Perico N, Benigni A. New therapeutics that antagonize endothelin: promises and frustrations. Nat Rev Drug Discov 2002;1(12):986-1001
    • (2002) Nat Rev Drug Discov , vol.1 , Issue.12 , pp. 986-1001
    • Remuzzi, G.1    Perico, N.2    Benigni, A.3
  • 16
    • 0033761323 scopus 로고    scopus 로고
    • Endothelin receptor expression in colorectal cancer
    • Ali H, Dashwood M, Dawas K, et al. Endothelin receptor expression in colorectal cancer. J Cardiovasc Pharmacol 2000 36(5 Suppl 1):S69-71
    • (2000) J Cardiovasc Pharmacol , vol.36 , Issue.5 SUPPL. 1
    • Ali, H.1    Dashwood, M.2    Dawas, K.3
  • 17
    • 0024523036 scopus 로고
    • Endothelin-1 receptors in cultured vascular smooth muscle cells and cardiocytes of rats
    • Hirata Y. Endothelin-1 receptors in cultured vascular smooth muscle cells and cardiocytes of rats. J Cardiovasc Pharmacol 1989;13(Suppl 5):S157-8
    • (1989) J Cardiovasc Pharmacol , vol.13 , Issue.SUPPL. 5
    • Hirata, Y.1
  • 18
    • 0024833565 scopus 로고
    • Endothelin potentiates growth factor-stimulated DNA synthesis in Swiss 3T3 cells
    • Kusuhara M, Yamaguchi K, Ohnishi A, et al. Endothelin potentiates growth factor-stimulated DNA synthesis in Swiss 3T3 cells. Jpn J Cancer Res 1989;80(4):302-5
    • (1989) Jpn J Cancer Res , vol.80 , Issue.4 , pp. 302-305
    • Kusuhara, M.1    Yamaguchi, K.2    Ohnishi, A.3
  • 19
    • 0026354436 scopus 로고
    • Endothelin-1 as an autocrine/paracrine factor for human tumor cell lines
    • Shichiri M, Hirata Y, Marumo F. Endothelin-1 as an autocrine/paracrine factor for human tumor cell lines. J Cardiovasc Pharmacol 1991;17(Suppl 7):S76-8
    • (1991) J Cardiovasc Pharmacol , vol.17 , Issue.SUPPL. 7
    • Shichiri, M.1    Hirata, Y.2    Marumo, F.3
  • 20
    • 0024565770 scopus 로고
    • Endothelin-1 activates the phosphoinositide cascade in cultured glomerular mesangial cells
    • discussion S4
    • Simonson MS, Wann S, Mene P, et al. Endothelin-1 activates the phosphoinositide cascade in cultured glomerular mesangial cells. J Cardiovasc Pharmacol 1989;13(Suppl 5):S80-3, discussion S4
    • (1989) J Cardiovasc Pharmacol , vol.13 , Issue.SUPPL. 5
    • Simonson, M.S.1    Wann, S.2    Mene, P.3
  • 21
    • 29144470972 scopus 로고    scopus 로고
    • Emerging role of the endothelin axis in ovarian tumor progression
    • Bagnato A, Spinella F, Rosano L. Emerging role of the endothelin axis in ovarian tumor progression. Endocr Relat Cancer 2005;12(4):761-72
    • (2005) Endocr Relat Cancer , vol.12 , Issue.4 , pp. 761-772
    • Bagnato, A.1    Spinella, F.2    Rosano, L.3
  • 22
    • 42949127145 scopus 로고    scopus 로고
    • Endothelin (ET)-1 and ET-3 promote expression of c-fos and c-jun in human choriocarcinoma via ET(B) receptor-mediated G(i)- and G (q)-pathways and MAP kinase activation
    • Rauh A, Windischhofer W, Kovacevic A, et al. Endothelin (ET)-1 and ET-3 promote expression of c-fos and c-jun in human choriocarcinoma via ET(B) receptor-mediated G(i)- and G (q)-pathways and MAP kinase activation. Br J Pharmacol 2008;154(1):13-24
    • (2008) Br J Pharmacol , vol.154 , Issue.1 , pp. 13-24
    • Rauh, A.1    Windischhofer, W.2    Kovacevic, A.3
  • 23
    • 0032213023 scopus 로고    scopus 로고
    • Endothelins as autocrine regulators of tumor cell growth
    • Bagnato A, Catt KJ. Endothelins as autocrine regulators of tumor cell growth. Trends Endocrinol Metab 1998;9(9):378-83
    • (1998) Trends Endocrinol Metab , vol.9 , Issue.9 , pp. 378-383
    • Bagnato, A.1    Catt, K.J.2
  • 24
    • 0030903110 scopus 로고    scopus 로고
    • Activation of mitogenic signaling by endothelin 1 in ovarian carcinoma cells
    • Bagnato A, Tecce R, Di Castro V, Catt KJ. Activation of mitogenic signaling by endothelin 1 in ovarian carcinoma cells. Cancer Res 1997;57(7):1306-11
    • (1997) Cancer Res , vol.57 , Issue.7 , pp. 1306-1311
    • Bagnato, A.1    Tecce, R.2    Di Castro, V.3    Catt, K.J.4
  • 25
    • 0034665584 scopus 로고    scopus 로고
    • Transactivation of the epidermal growth factor receptor in endothelin-1-induced mitogenic signaling in human ovarian carcinoma cells
    • Vacca F, Bagnato A, Catt KJ, Tecce R. Transactivation of the epidermal growth factor receptor in endothelin-1-induced mitogenic signaling in human ovarian carcinoma cells. Cancer Res 2000;60(18):5310-7
    • (2000) Cancer Res , vol.60 , Issue.18 , pp. 5310-5317
    • Vacca, F.1    Bagnato, A.2    Catt, K.J.3    Tecce, R.4
  • 26
    • 0028079673 scopus 로고
    • Phenotypic change of endothelin receptor subtype in cultured rat vascular smooth muscle cells
    • Eguchi S, Hirata Y, Imai T, et al. Phenotypic change of endothelin receptor subtype in cultured rat vascular smooth muscle cells. Endocrinology 1994;134(1):222-8
    • (1994) Endocrinology , vol.134 , Issue.1 , pp. 222-228
    • Eguchi, S.1    Hirata, Y.2    Imai, T.3
  • 27
    • 0027474635 scopus 로고
    • Growth regulatory properties of endothelins
    • Battistini B, Chailler P, D'Orleans-Juste P, et al. Growth regulatory properties of endothelins. Peptides 1993;14(2):385-99
    • (1993) Peptides , vol.14 , Issue.2 , pp. 385-399
    • Battistini, B.1    Chailler, P.2    D'Orleans-Juste, P.3
  • 28
    • 0034648765 scopus 로고    scopus 로고
    • Angiogenesis in cancer and other diseases
    • Carmeliet P, Jain RK. Angiogenesis in cancer and other diseases. Nature 2000;407(6801):249-57
    • (2000) Nature , vol.407 , Issue.6801 , pp. 249-257
    • Carmeliet, P.1    Jain, R.K.2
  • 29
    • 0033724661 scopus 로고    scopus 로고
    • Endothelin-1 induces an angiogenic phenotype in cultured endothelial cells and stimulates neovascularization in vivo
    • Salani D, Taraboletti G, Rosano L, et al. Endothelin-1 induces an angiogenic phenotype in cultured endothelial cells and stimulates neovascularization in vivo. Am J Pathol 2000;157(5):1703-11
    • (2000) Am J Pathol , vol.157 , Issue.5 , pp. 1703-1711
    • Salani, D.1    Taraboletti, G.2    Rosano, L.3
  • 30
    • 0037112435 scopus 로고    scopus 로고
    • Growth inhibition of cervix carcinoma cells in vivo by endothelin A receptor blockade
    • Bagnato A, Cirilli A, Salani D, et al. Growth inhibition of cervix carcinoma cells in vivo by endothelin A receptor blockade. Cancer Res 2002;62(22):6381-4
    • (2002) Cancer Res , vol.62 , Issue.22 , pp. 6381-6384
    • Bagnato, A.1    Cirilli, A.2    Salani, D.3
  • 31
    • 0346368096 scopus 로고    scopus 로고
    • Targeting cyclooxygenase-2 in human neoplasia: Rationale and promise
    • Dannenberg AJ, Subbaramaiah K. Targeting cyclooxygenase-2 in human neoplasia: rationale and promise. Cancer Cell 2003;4(6):431-6
    • (2003) Cancer Cell , vol.4 , Issue.6 , pp. 431-436
    • Dannenberg, A.J.1    Subbaramaiah, K.2
  • 32
    • 0036124320 scopus 로고    scopus 로고
    • Expression of cyclooxygenase 2 is an independent prognostic factor in human ovarian carcinoma
    • Denkert C, Kobel M, Pest S, et al. Expression of cyclooxygenase 2 is an independent prognostic factor in human ovarian carcinoma. Am J Pathol 2002;160(3):893-903
    • (2002) Am J Pathol , vol.160 , Issue.3 , pp. 893-903
    • Denkert, C.1    Kobel, M.2    Pest, S.3
  • 33
    • 0036668661 scopus 로고    scopus 로고
    • Increased cyclooxygenase-2 (COX-2) expression is associated with chemotherapy resistance and outcome in ovarian cancer patients
    • Ferrandina G, Lauriola L, Zannoni GF, et al. Increased cyclooxygenase-2 (COX-2) expression is associated with chemotherapy resistance and outcome in ovarian cancer patients. Ann Oncol 2002;13(8):1205-11
    • (2002) Ann Oncol , vol.13 , Issue.8 , pp. 1205-1211
    • Ferrandina, G.1    Lauriola, L.2    Zannoni, G.F.3
  • 34
    • 0030800070 scopus 로고    scopus 로고
    • Inhibition of death receptor signals by cellular FLIP
    • Irmler M, Thome M, Hahne M, et al. Inhibition of death receptor signals by cellular FLIP. Nature 1997;388(6638):190-5
    • (1997) Nature , vol.388 , Issue.6638 , pp. 190-195
    • Irmler, M.1    Thome, M.2    Hahne, M.3
  • 35
    • 20244377662 scopus 로고    scopus 로고
    • The endothelin system in human glioblastoma
    • Egidy G, Eberl LP, Valdenaire O, et al. The endothelin system in human glioblastoma. Lab Invest 2000;80(11):1681-9
    • (2000) Lab Invest , vol.80 , Issue.11 , pp. 1681-1689
    • Egidy, G.1    Eberl, L.P.2    Valdenaire, O.3
  • 36
    • 0037430039 scopus 로고    scopus 로고
    • Endothelin-receptor antagonists are proapoptotic and antiproliferative in human colon cancer cells
    • Peduto Eberl L, Bovey R, Juillerat-Jeanneret L. Endothelin-receptor antagonists are proapoptotic and antiproliferative in human colon cancer cells. Br J Cancer 2003;88(5):788-95
    • (2003) Br J Cancer , vol.88 , Issue.5 , pp. 788-795
    • Peduto Eberl, L.1    Bovey, R.2    Juillerat-Jeanneret, L.3
  • 37
    • 0032524338 scopus 로고    scopus 로고
    • Endothelin-induced apoptosis of A375 human melanoma cells
    • Okazawa M, Shiraki T, Ninomiya H, et al. Endothelin-induced apoptosis of A375 human melanoma cells. J Biol Chem 1998;273(20):12584-92
    • (1998) J Biol Chem , vol.273 , Issue.20 , pp. 12584-12592
    • Okazawa, M.1    Shiraki, T.2    Ninomiya, H.3
  • 38
    • 0033724657 scopus 로고    scopus 로고
    • Role of endothelin-1 in neovascularization of ovarian carcinoma
    • Salani D, Di Castro V, Nicotra MR, et al. Role of endothelin-1 in neovascularization of ovarian carcinoma. Am J Pathol 2000;157(5):1537-47
    • (2000) Am J Pathol , vol.157 , Issue.5 , pp. 1537-1547
    • Salani, D.1    Di Castro, V.2    Nicotra, M.R.3
  • 39
    • 8744250174 scopus 로고    scopus 로고
    • Endothelin-1-induced prostaglandin E2-EP2, EP4 signaling regulates vascular endothelial growth factor production and ovarian carcinoma cell invasion
    • Spinella F, Rosano L, Di Castro V, et al. Endothelin-1-induced prostaglandin E2-EP2, EP4 signaling regulates vascular endothelial growth factor production and ovarian carcinoma cell invasion. J Biol Chem 2004;279(45):46700-5
    • (2004) J Biol Chem , vol.279 , Issue.45 , pp. 46700-46705
    • Spinella, F.1    Rosano, L.2    Di Castro, V.3
  • 40
    • 0142135067 scopus 로고    scopus 로고
    • Endothelin-1 decreases gap junctional intercellular communication by inducing phosphorylation of connexin 43 in human ovarian carcinoma cells
    • Spinella F, Rosano L, Di Castro V, et al. Endothelin-1 decreases gap junctional intercellular communication by inducing phosphorylation of connexin 43 in human ovarian carcinoma cells. J Biol Chem 2003;278(42):41294-301
    • (2003) J Biol Chem , vol.278 , Issue.42 , pp. 41294-41301
    • Spinella, F.1    Rosano, L.2    Di Castro, V.3
  • 41
    • 29144495415 scopus 로고    scopus 로고
    • Endothelin-1 promotes epithelial-to-mesenchymal transition in human ovarian cancer cells
    • Rosano L, Spinella F, Di Castro V, et al. Endothelin-1 promotes epithelial-to-mesenchymal transition in human ovarian cancer cells. Cancer Res 2005;65(24):11649-57
    • (2005) Cancer Res , vol.65 , Issue.24 , pp. 11649-11657
    • Rosano, L.1    Spinella, F.2    Di Castro, V.3
  • 42
    • 0029085123 scopus 로고
    • Identification of endothelin-1 in the pathophysiology of metastatic adenocarcinoma of the prostate
    • Nelson JB, Hedican SP, George DJ, et al. Identification of endothelin-1 in the pathophysiology of metastatic adenocarcinoma of the prostate. Nat Med 1995;1(9):944-9
    • (1995) Nat Med , vol.1 , Issue.9 , pp. 944-949
    • Nelson, J.B.1    Hedican, S.P.2    George, D.J.3
  • 43
    • 33750728404 scopus 로고    scopus 로고
    • Targeting bone metastasis in prostate cancer with endothelin receptor antagonists
    • Carducci MA, Jimeno A. Targeting bone metastasis in prostate cancer with endothelin receptor antagonists. Clin Cancer Res 2006;12(20 Pt 2):6296s-300s
    • (2006) Clin Cancer Res , vol.12 , Issue.20 PART 2
    • Carducci, M.A.1    Jimeno, A.2
  • 44
    • 0033010543 scopus 로고    scopus 로고
    • New bone formation in an osteoblastic tumor model is increased by endothelin-1 overexpression and decreased by endothelin A receptor blockade
    • Nelson JB, Nguyen SH, Wu-Wong JR, et al. New bone formation in an osteoblastic tumor model is increased by endothelin-1 overexpression and decreased by endothelin A receptor blockade. Urology 1999;53(5):1063-9
    • (1999) Urology , vol.53 , Issue.5 , pp. 1063-1069
    • Nelson, J.B.1    Nguyen, S.H.2    Wu-Wong, J.R.3
  • 45
    • 0037303203 scopus 로고    scopus 로고
    • Role of endothelin-1 in osteoblastic bone metastases
    • Guise TA, Yin JJ, Mohammad KS. Role of endothelin-1 in osteoblastic bone metastases. Cancer 2003;97(Suppl 3):779-84
    • (2003) Cancer , vol.97 , Issue.SUPPL. 3 , pp. 779-784
    • Guise, T.A.1    Yin, J.J.2    Mohammad, K.S.3
  • 46
    • 0141479984 scopus 로고    scopus 로고
    • A causal role for endothelin-1 in the pathogenesis of osteoblastic bone metastases
    • Yin JJ, Mohammad KS, Kakonen SM, et al. A causal role for endothelin-1 in the pathogenesis of osteoblastic bone metastases. Proc Natl Acad Sci USA 2003;100(19):10954-9
    • (2003) Proc Natl Acad Sci USA , vol.100 , Issue.19 , pp. 10954-10959
    • Yin, J.J.1    Mohammad, K.S.2    Kakonen, S.M.3
  • 47
    • 0035924359 scopus 로고    scopus 로고
    • Endothelin-1 synthesis reduced by red wine
    • Corder R, Douthwaite JA, Lees DM, et al. Endothelin-1 synthesis reduced by red wine. Nature 2001;414(6866):863-4
    • (2001) Nature , vol.414 , Issue.6866 , pp. 863-864
    • Corder, R.1    Douthwaite, J.A.2    Lees, D.M.3
  • 48
    • 33746038556 scopus 로고    scopus 로고
    • Green tea polyphenol epigallocatechin-3-gallate inhibits the endothelin axis and downstream signaling pathways in ovarian carcinoma
    • Spinella F, Rosano L, Di Castro V, et al. Green tea polyphenol epigallocatechin-3-gallate inhibits the endothelin axis and downstream signaling pathways in ovarian carcinoma. Mol Cancer Ther 2006;5(6):1483-92
    • (2006) Mol Cancer Ther , vol.5 , Issue.6 , pp. 1483-1492
    • Spinella, F.1    Rosano, L.2    Di Castro, V.3
  • 49
    • 0036099334 scopus 로고    scopus 로고
    • Nonpeptidic endothelin-converting enzyme inhibitors and their potential therapeutic applications
    • Jeng AY, Mulder P, Kwan AL, Battistini B. Nonpeptidic endothelin-converting enzyme inhibitors and their potential therapeutic applications. Can J Physiol Pharmacol 2002;80(5):440-9
    • (2002) Can J Physiol Pharmacol , vol.80 , Issue.5 , pp. 440-449
    • Jeng, A.Y.1    Mulder, P.2    Kwan, A.L.3    Battistini, B.4
  • 50
    • 16344379860 scopus 로고    scopus 로고
    • Neutral endopeptidase 24.11/CD10 suppresses progressive potential in ovarian carcinoma in vitro and in vivo
    • Kajiyama H, Shibata K, Terauchi M, et al. Neutral endopeptidase 24.11/CD10 suppresses progressive potential in ovarian carcinoma in vitro and in vivo. Clin Cancer Res 2005;11(5):1798-808
    • (2005) Clin Cancer Res , vol.11 , Issue.5 , pp. 1798-1808
    • Kajiyama, H.1    Shibata, K.2    Terauchi, M.3
  • 51
    • 0037843596 scopus 로고    scopus 로고
    • Therapeutic targeting of the endothelin a receptor in human ovarian carcinoma
    • Rosano L, Spinella F, Salani D, et al. Therapeutic targeting of the endothelin a receptor in human ovarian carcinoma. Cancer Res 2003;63(10):2447-53
    • (2003) Cancer Res , vol.63 , Issue.10 , pp. 2447-2453
    • Rosano, L.1    Spinella, F.2    Salani, D.3
  • 52
    • 24344485096 scopus 로고    scopus 로고
    • Gene expression profiles associated with response to chemotherapy in epithelial ovarian cancers
    • Jazaeri AA, Awtrey CS, Chandramouli GV, et al. Gene expression profiles associated with response to chemotherapy in epithelial ovarian cancers. Clin Cancer Res 2005;11(17):6300-10
    • (2005) Clin Cancer Res , vol.11 , Issue.17 , pp. 6300-6310
    • Jazaeri, A.A.1    Awtrey, C.S.2    Chandramouli, G.V.3
  • 53
    • 34547556790 scopus 로고    scopus 로고
    • The endothelin axis: A novel target for pharmacotherapy of female malignancies
    • Smollich M, Wulfing P. The endothelin axis: a novel target for pharmacotherapy of female malignancies. Curr Vasc Pharmacol 2007;5(3):239-48
    • (2007) Curr Vasc Pharmacol , vol.5 , Issue.3 , pp. 239-248
    • Smollich, M.1    Wulfing, P.2
  • 54
    • 0033746814 scopus 로고    scopus 로고
    • Expression of endothelin 1 and endothelin A receptor in HPV-associated cervical carcinoma: New potential targets for anticancer therapy
    • Venuti A, Salani D, Manni V, et al. Expression of endothelin 1 and endothelin A receptor in HPV-associated cervical carcinoma: new potential targets for anticancer therapy. FASEB J 2000;14(14):2277-83
    • (2000) FASEB J , vol.14 , Issue.14 , pp. 2277-2283
    • Venuti, A.1    Salani, D.2    Manni, V.3
  • 55
    • 33645818167 scopus 로고    scopus 로고
    • Elevated plasma big ET-1 is associated with distant failure in patients with advanced-stage nasopharyngeal carcinoma
    • Mai HQ, Zeng ZY, Zhang CQ, et al. Elevated plasma big ET-1 is associated with distant failure in patients with advanced-stage nasopharyngeal carcinoma. Cancer 2006;106(7):1548-53
    • (2006) Cancer , vol.106 , Issue.7 , pp. 1548-1553
    • Mai, H.Q.1    Zeng, Z.Y.2    Zhang, C.Q.3
  • 56
    • 33750338107 scopus 로고    scopus 로고
    • Therapeutic targeting of the endothelin a receptor in human nasopharyngeal carcinoma
    • Mai HQ, Zeng ZY, Feng KT, et al. Therapeutic targeting of the endothelin a receptor in human nasopharyngeal carcinoma. Cancer Sci 2006;97(12):1388-95
    • (2006) Cancer Sci , vol.97 , Issue.12 , pp. 1388-1395
    • Mai, H.Q.1    Zeng, Z.Y.2    Feng, K.T.3
  • 57
    • 23844468385 scopus 로고    scopus 로고
    • Endothelin axis is a target of the lung metastasis suppressor gene RhoGDI2
    • Titus B, Frierson HF Jr, Conaway M, et al. Endothelin axis is a target of the lung metastasis suppressor gene RhoGDI2. Cancer Res 2005;65(16):7320-7
    • (2005) Cancer Res , vol.65 , Issue.16 , pp. 7320-7327
    • Titus, B.1    Frierson Jr, H.F.2    Conaway, M.3
  • 58
    • 33744928079 scopus 로고    scopus 로고
    • ZD4054, a potent endothelin receptor A antagonist, inhibits ovarian carcinoma cell proliferation
    • Rosano L, Di Castro V, Spinella F, et al. ZD4054, a potent endothelin receptor A antagonist, inhibits ovarian carcinoma cell proliferation. Exp Biol Med (Maywood) 2006;231(6):1132-5
    • (2006) Exp Biol Med (Maywood) , vol.231 , Issue.6 , pp. 1132-1135
    • Rosano, L.1    Di Castro, V.2    Spinella, F.3
  • 59
    • 34447128915 scopus 로고    scopus 로고
    • ZD4054, a specific antagonist of the endothelin A receptor, inhibits tumor growth and enhances paclitaxel activity in human ovarian carcinoma in vitro and in vivo
    • Rosano L, Di Castro V, Spinella F, et al. ZD4054, a specific antagonist of the endothelin A receptor, inhibits tumor growth and enhances paclitaxel activity in human ovarian carcinoma in vitro and in vivo. Mol Cancer Ther 2007;6(7):2003-11
    • (2007) Mol Cancer Ther , vol.6 , Issue.7 , pp. 2003-2011
    • Rosano, L.1    Di Castro, V.2    Spinella, F.3
  • 60
    • 34447136110 scopus 로고    scopus 로고
    • Combined targeting of endothelin A receptor and epidermal growth factor receptor in ovarian cancer shows enhanced antitumor activity
    • Rosano L, Di Castro V, Spinella F, et al. Combined targeting of endothelin A receptor and epidermal growth factor receptor in ovarian cancer shows enhanced antitumor activity. Cancer Res 2007;67(13):6351-9
    • (2007) Cancer Res , vol.67 , Issue.13 , pp. 6351-6359
    • Rosano, L.1    Di Castro, V.2    Spinella, F.3
  • 61
    • 33744931372 scopus 로고    scopus 로고
    • Targeting the endothelin axis in human melanoma: Combination of endothelin receptor antagonism and alkylating agents
    • Berger Y, Bernasconi CC, Juillerat-Jeanneret L. Targeting the endothelin axis in human melanoma: combination of endothelin receptor antagonism and alkylating agents. Exp Biol Med (Maywood) 2006;231(6):1111-9
    • (2006) Exp Biol Med (Maywood) , vol.231 , Issue.6 , pp. 1111-1119
    • Berger, Y.1    Bernasconi, C.C.2    Juillerat-Jeanneret, L.3
  • 62
    • 0035101532 scopus 로고    scopus 로고
    • Endothelin receptor blockade inhibits proliferation of Kaposi's sarcoma cells
    • Bagnato A, Rosano L, Di Castro V, et al. Endothelin receptor blockade inhibits proliferation of Kaposi's sarcoma cells. Am J Pathol 2001;158(3):841-7
    • (2001) Am J Pathol , vol.158 , Issue.3 , pp. 841-847
    • Bagnato, A.1    Rosano, L.2    Di Castro, V.3
  • 63
    • 0042845963 scopus 로고    scopus 로고
    • Endothelin receptor blockade inhibits molecular effectors of Kaposi's sarcoma cell invasion and tumor growth in vivo
    • Rosano L, Spinella F, Di Castro V, et al. Endothelin receptor blockade inhibits molecular effectors of Kaposi's sarcoma cell invasion and tumor growth in vivo. Am J Pathol 2003;163(2):753-62
    • (2003) Am J Pathol , vol.163 , Issue.2 , pp. 753-762
    • Rosano, L.1    Spinella, F.2    Di Castro, V.3
  • 64
    • 0033613134 scopus 로고    scopus 로고
    • An endothelin receptor B antagonist inhibits growth and induces cell death in human melanoma cells in vitro and in vivo
    • Lahav R, Heffner G, Patterson PH. An endothelin receptor B antagonist inhibits growth and induces cell death in human melanoma cells in vitro and in vivo. Proc Natl Acad Sci USA 1999;96(20):11496-500
    • (1999) Proc Natl Acad Sci USA , vol.96 , Issue.20 , pp. 11496-11500
    • Lahav, R.1    Heffner, G.2    Patterson, P.H.3
  • 65
    • 33847737677 scopus 로고    scopus 로고
    • Endothelin-1 and endothelin-3 promote invasive behavior via hypoxia-inducible factor-1alpha in human melanoma cells
    • Spinella F, Rosano L, Di Castro V, et al. Endothelin-1 and endothelin-3 promote invasive behavior via hypoxia-inducible factor-1alpha in human melanoma cells. Cancer Res 2007;67(4):1725-34
    • (2007) Cancer Res , vol.67 , Issue.4 , pp. 1725-1734
    • Spinella, F.1    Rosano, L.2    Di Castro, V.3
  • 66
    • 0035066386 scopus 로고    scopus 로고
    • Single-dose pharmacokinetics of atrasentan, an endothelin-A receptor antagonist
    • Samara E, Dutta S, Cao G, et al. Single-dose pharmacokinetics of atrasentan, an endothelin-A receptor antagonist. J Clin Pharmacol 2001;41(4):397-403
    • (2001) J Clin Pharmacol , vol.41 , Issue.4 , pp. 397-403
    • Samara, E.1    Dutta, S.2    Cao, G.3
  • 67
    • 22044435149 scopus 로고    scopus 로고
    • Specific inhibition of the endothelin A receptor with ZD4054: Clinical and pre-clinical evidence
    • Morris CD, Rose A, Curwen J, et al. Specific inhibition of the endothelin A receptor with ZD4054: clinical and pre-clinical evidence. Br J Cancer 2005;92(12):2148-52
    • (2005) Br J Cancer , vol.92 , Issue.12 , pp. 2148-2152
    • Morris, C.D.1    Rose, A.2    Curwen, J.3
  • 68
    • 0037441843 scopus 로고    scopus 로고
    • Effect of endothelin-A receptor blockade with atrasentan on tumor progression in men with hormone-refractory prostate cancer: A randomized, phase II, placebo-controlled trial
    • Carducci MA, Padley RJ, Breul J, et al. Effect of endothelin-A receptor blockade with atrasentan on tumor progression in men with hormone-refractory prostate cancer: a randomized, phase II, placebo-controlled trial. J Clin Oncol 2003;21(4):679-89
    • (2003) J Clin Oncol , vol.21 , Issue.4 , pp. 679-689
    • Carducci, M.A.1    Padley, R.J.2    Breul, J.3
  • 69
    • 0041464540 scopus 로고    scopus 로고
    • Phase I dose-escalation study of the safety and pharmacokinetics of atrasentan: An endothelin receptor antagonist for refractory prostate cancer
    • Zonnenberg BA, Groenewegen G, Janus TJ, et al. Phase I dose-escalation study of the safety and pharmacokinetics of atrasentan: an endothelin receptor antagonist for refractory prostate cancer. Clin Cancer Res 2003;9(8):2965-72
    • (2003) Clin Cancer Res , vol.9 , Issue.8 , pp. 2965-2972
    • Zonnenberg, B.A.1    Groenewegen, G.2    Janus, T.J.3
  • 70
    • 0024514405 scopus 로고
    • Endothelin-1 participation in overt and inflammatory pain
    • Ferreira SH, Romitelli M, de Nucci G. Endothelin-1 participation in overt and inflammatory pain. J Cardiovasc Pharmacol 1989;13(Suppl 5):S220-2
    • (1989) J Cardiovasc Pharmacol , vol.13 , Issue.SUPPL. 5
    • Ferreira, S.H.1    Romitelli, M.2    de Nucci, G.3
  • 72
    • 0041888477 scopus 로고    scopus 로고
    • Endothelin-B receptor activation triggers an endogenous analgesic cascade at sites of peripheral injury
    • Khodorova A, Navarro B, Jouaville LS, et al. Endothelin-B receptor activation triggers an endogenous analgesic cascade at sites of peripheral injury. Nat Med 2003;9(8):1055-61
    • (2003) Nat Med , vol.9 , Issue.8 , pp. 1055-1061
    • Khodorova, A.1    Navarro, B.2    Jouaville, L.S.3
  • 73
    • 15844427940 scopus 로고    scopus 로고
    • Endothelin receptor antagonists
    • Nelson JB. Endothelin receptor antagonists. World J Urol 2005;23(1):19-27
    • (2005) World J Urol , vol.23 , Issue.1 , pp. 19-27
    • Nelson, J.B.1
  • 74
    • 0037364732 scopus 로고    scopus 로고
    • Suppression of prostate cancer induced bone remodeling by the endothelin receptor A antagonist atrasentan
    • Nelson JB, Nabulsi AA, Vogelzang NJ, et al. Suppression of prostate cancer induced bone remodeling by the endothelin receptor A antagonist atrasentan. J Urol 2003;169(3):1143-9
    • (2003) J Urol , vol.169 , Issue.3 , pp. 1143-1149
    • Nelson, J.B.1    Nabulsi, A.A.2    Vogelzang, N.J.3
  • 75
    • 0024846508 scopus 로고
    • Endothelin-1 activates phospholipase C and mobilizes Ca2+ from extra- and intracellular pools in osteoblastic cells
    • Takuwa Y, Ohue Y, Takuwa N, Yamashita K. Endothelin-1 activates phospholipase C and mobilizes Ca2+ from extra- and intracellular pools in osteoblastic cells. Am J Physiol 1989;257(6 Pt 1):E797-803
    • (1989) Am J Physiol , vol.257 , Issue.6 PART 1
    • Takuwa, Y.1    Ohue, Y.2    Takuwa, N.3    Yamashita, K.4
  • 76
    • 35648968713 scopus 로고    scopus 로고
    • A phase 3 randomized controlled trial of the efficacy and safety of atrasentan in men with metastatic hormone-refractory prostate cancer
    • Carducci MA, Saad F, Abrahamsson PA, et al. A phase 3 randomized controlled trial of the efficacy and safety of atrasentan in men with metastatic hormone-refractory prostate cancer. Cancer 2007;110(9):1959-66
    • (2007) Cancer , vol.110 , Issue.9 , pp. 1959-1966
    • Carducci, M.A.1    Saad, F.2    Abrahamsson, P.A.3
  • 77
    • 55549112219 scopus 로고    scopus 로고
    • Phase 3, randomized, controlled trial of atrasentan in patients with nonmetastatic, hormone-refractory prostate cancer
    • Nelson JB, Love W, Chin JL, et al. Phase 3, randomized, controlled trial of atrasentan in patients with nonmetastatic, hormone-refractory prostate cancer. Cancer 2008;113(9):2478-87
    • (2008) Cancer , vol.113 , Issue.9 , pp. 2478-2487
    • Nelson, J.B.1    Love, W.2    Chin, J.L.3
  • 78
    • 33746278493 scopus 로고    scopus 로고
    • Randomized phase II study of atrasentan alone or in combination with zoledronic acid in men with metastatic prostate cancer
    • Michaelson MD, Kaufman DS, Kantoff P, et al. Randomized phase II study of atrasentan alone or in combination with zoledronic acid in men with metastatic prostate cancer. Cancer 2006;107(3):530-5
    • (2006) Cancer , vol.107 , Issue.3 , pp. 530-535
    • Michaelson, M.D.1    Kaufman, D.S.2    Kantoff, P.3
  • 79
    • 58149143013 scopus 로고    scopus 로고
    • A phase I-II study of docetaxel and atrasentan in men with castration-resistant metastatic prostate cancer
    • Armstrong AJ, Creel P, Turnbull J, et al. A phase I-II study of docetaxel and atrasentan in men with castration-resistant metastatic prostate cancer. Clin Cancer Res 2008;14(19):6270-6
    • (2008) Clin Cancer Res , vol.14 , Issue.19 , pp. 6270-6276
    • Armstrong, A.J.1    Creel, P.2    Turnbull, J.3
  • 80
    • 40949108811 scopus 로고    scopus 로고
    • Phase I/II study of atrasentan, an endothelin A receptor antagonist, in combination with paclitaxel and carboplatin as first-line therapy in advanced non-small cell lung cancer
    • Chiappori AA, Haura E, Rodriguez FA, et al. Phase I/II study of atrasentan, an endothelin A receptor antagonist, in combination with paclitaxel and carboplatin as first-line therapy in advanced non-small cell lung cancer. Clin Cancer Res 2008;14(5):1464-9
    • (2008) Clin Cancer Res , vol.14 , Issue.5 , pp. 1464-1469
    • Chiappori, A.A.1    Haura, E.2    Rodriguez, F.A.3
  • 81
    • 62649134676 scopus 로고    scopus 로고
    • Safety and efficacy of the specific endothelin-A receptor antagonist ZD4054 in patients with hormone-resistant prostate cancer and bone metastases who were pain free or mildly symptomatic: A double-blind, placebo-controlled, randomised, phase 2 trial
    • James ND, Caty A, Borre M, et al. Safety and efficacy of the specific endothelin-A receptor antagonist ZD4054 in patients with hormone-resistant prostate cancer and bone metastases who were pain free or mildly symptomatic: a double-blind, placebo-controlled, randomised, phase 2 trial. Eur Urol 2009;55(5):1112-23
    • (2009) Eur Urol , vol.55 , Issue.5 , pp. 1112-1123
    • James, N.D.1    Caty, A.2    Borre, M.3
  • 82
    • 79151468942 scopus 로고    scopus 로고
    • A phase I study of zibotentan (ZD4054) in patients with metastatic, castrate-resistant prostate cancer
    • doi: 10.1007/s10637-009-9318-5
    • Schelman WR, Liu G, Wilding G, et al. A phase I study of zibotentan (ZD4054) in patients with metastatic, castrate-resistant prostate cancer. Invest New Drugs 2009, doi: 10.1007/s10637-009-9318-5
    • (2009) Invest New Drugs
    • Schelman, W.R.1    Liu, G.2    Wilding, G.3
  • 83
    • 34248667859 scopus 로고    scopus 로고
    • A phase II study of bosentan, a dual endothelin receptor antagonist, as monotherapy in patients with stage IV metastatic melanoma
    • Kefford R, Beith JM, Van Hazel GA, et al. A phase II study of bosentan, a dual endothelin receptor antagonist, as monotherapy in patients with stage IV metastatic melanoma. Invest New Drugs 2007;25(3):247-52
    • (2007) Invest New Drugs , vol.25 , Issue.3 , pp. 247-252
    • Kefford, R.1    Beith, J.M.2    Van Hazel, G.A.3


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