Malignant bone pain: Pathophysiology and treatment

Pain

Volumn 69, Issue 1-2, 1997, Pages 1-18

  Mercadante, Sebastiano ^a,b  

^a Buccheri La Ferla Hospital   (Italy)

^b SAMOT Onlus   (Italy)

Author keywords

Bisphosphonates; Blocks; Bone metastases; Cancer pain; Chemotherapy; Cordotomy; Hypercalcemia; Incident pain; Invasive techniques; NSAIDs; Opioids; Orthopedic; Radioisotopes; Radiotherapy; Surgery

Indexed keywords

ANALGESIC AGENT; ANTIANDROGEN; ANTINEOPLASTIC AGENT; BISPHOSPHONIC ACID DERIVATIVE; CHOLINE MAGNESIUM TRISALICYLATE; CORTICOSTEROID; ESTROGEN; GONADORELIN DERIVATIVE; NONSTEROID ANTIINFLAMMATORY AGENT; OPIATE;

BONE METASTASIS; CANCER PAIN; CLINICAL TRIAL; HUMAN; PRIORITY JOURNAL; REVIEW;

ANIMALS; BONE NEOPLASMS; HUMANS; PAIN;

EID: 0031056437     PISSN: 03043959     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3959(96)03267-8     Document Type: Review

References (169)

1. Aaron, A.D., The management of cancer metastatic to bone, J. Am. Med. Assoc., 272 (1994) 1206-1209.
2. Adami, S., Salvagno, G., Guerra, G. et al., Dichloromethylene diphosphonate in patients with prostatic carcinoma metastatic to the skeleton, J. Urol., 134 (1985) 1152-1154.
3. Aguilar, J.L., Montes, A., Samper, D., Roca, G. and Vidal, F., Interpleural analgesia through a Du Pen catheter in lung cancer pain, Cancer, 70 (1992) 2621-2623.
4. Arner, S. and Arner, B., Differential effects of epidural morphine in the treatment of cancer-related pain, Acta Anaesthesiol. Scand., 29 (1985) 32-36.
5. Ashby, M., The role of radiotherapy in palliative care, J. Pain Symptom Manage., 6 (1991) 380-388.
6. Ashby, M., Radiotherapy in the palliation of cancer. In: R. Patt (Ed.), Cancer Pain, J.B. Lippincott, Philadelphia, 1993, pp. 235-249.
7. Baines, M. and Kirkham, S.R., Cancer Pain. In: P.D. Wall and R. Melzack (Eds.), Textbook of Pain, Churchill Livingstone, Edinburgh, 1989, pp. 590-597.
8. Banning, A., Sjogren, P. and Henriksen, H., Pain causes in 200 patients referred to a multidisciplinary cancer pain clinic, Pain, 45 (1991a) 45-48.
9. Banning, A., Sjogren, P. and Henriksen, H., Treatment outcome in a multidisciplinary cancer pain clinic, Pain, 47 (1991b) 129-134.
10. Bataille, R., Delmas, P.D., Chappard, D. and Sany, J., Prognostic implications of serum bone gla-protein levels in multiple myeloma: crucial role of bone formation, Cancer, 66 (1990) 167-172.
11. Bates, T., A review of local radiotherapy in the treatment of bone metastases and cord compression, Int. J. Radiat. Oncol. Biol. Phys., 23 (1992) 217-221.
12. Bennett, A., The role of biochemical factors in peripheral nociception and bone pain, Cancer Surv., 7 (1988) 55-67.
13. Berenson, J.R., Lichtenstein, A., Porter, L. et al., Efficacy of pamidronate in reducing skeletal events in patients with advanced multiple myeloma, N. Engl. J. Med., 334 (1996) 488-493.
14. Berrettoni, B.A. and Carter, J.R., Mechanisms of cancer metastasis to bone, J. Bone Joint Surg., 68A (1986) 308-312.
15. Bjurholm, A., Kreicbergs, A., Brodin, E. and Schultzberg, M., Substance P and CCRP-immunoreactive nerves in bone, Peptides, 9 (1988) 165-171.
16. Blake, G.M., Zivanovic, M.A., McEwan, A.J. and Ackery, D.M., Sr-89 therapy: strontium kinetics in disseminated carcinoma of the prostate, Eur. J. Nucl. Med., 12 (1986) 447-545.
17. Blitzer, P.H., Reanalysis of the RTOG study of the palliation of symptomatic osseous metastasis, Cancer, 55 (1985) 1468-1472.
18. Body, J.J., Pathophysiology of osteolysis: the putative mode of action of biphosphonates, Eur. J. Palliat. Care, 1 (1994) 116-121.
19. Bonjour, J.P. and Rizzoli, R., Pathophysiological aspects and therapeutic approaches of tumoral osteolysis and hypercalcemia, Rec. Res. Cancer Res., 116 (1989) 29-39.
20. Boturri, M., Zanni, D. and Tosi, G., Disodium clodronate and radiotherapy in bone metastases from solid tumours, Radio Med., 80 (1990) 726-733.
21. Breitbart, W., Psycho-oncology: depression, anxiety, delirium, Semin. Oncol., 21 (1994) 754-769.
22. Brescia, F.J., Adler, D., Gray, G. et al., Hospitalized advanced cancer patients: a profile, J. Pain Symptom Manage., 5 (1990) 221-227.
23. Brooks, P.M. and O'Day, R., Nonsteroidal anti-inflammatory drugs; differences and similarity, N. Engl. J. Med., 324 (1991) 1716-1725.
24. Bruera, E., Macmillan, K., Hanson, J. and MacDonald, R.N., The Edmonton staging system for cancer pain: preliminary report, Pain, 37 (1989) 203-209.
25. Bruera, E., MacMillan, K., Hanson, J. and MacDonald, N., The Edmonton injector: a simple device for patient-controlled subcutaneous analgesia, Pain, 44 (1991) 167-169.
26. Bruera, E., Fainsinger, R., MacEachern, T. et al., The use of methylphenidate in patients with incident cancer pain receiving regular opiates; a preliminary report, Pain, 50 (1992) 75-77.
27. Bruera, E., Bone Pain Due to Cancer; Refresher Course Syllabus, 7th World Congress on Pain, Paris, August 22-27, 1993, pp. 237-244.
28. Burtis, W.J., Parathyroid hormone-related protein: structure, function and measurement, Clin. Chem., 38 (1992) 2171-2183.
29. Burtis, W.J., We, T.L., Insogna, K.L. and Stewart, A.F., Humoral hyper-calcaemia of malignancy, Ann. Intern. Med., 108 (1988) 454-457.
30. Campa, J.A. and Payne, R., The management of intractable bone pain: a clinician's perspective, Semin. Nucl. Med., 22 (1992) 3-10.
31. Carter, R.L., Patterns and mechanisms of bone metastases, J. R. Soc. Med., 78 (Suppl. 9) (1985) 2-6.
32. Cascinu, S., Casadei, V., Del Ferro, E., Alessandroni, P. and Catalano, G., Pamidronate in patients with painful metastases, who failed initial treatment with hormones and/or chemotherapy, Support Care Cancer, 4 (1996) 31-33.
33. Chan, D., Carter, S.R., Grimer, R.J. and Sneath, R.S., Endoprosthetic replacement for bone metastases, Ann. R. Coll. Surg. Engl., 74 (1992) 13-18.
34. Chisholm, G.D., Rana, A. and Howard, G.C.W., Management options for painful carcinoma of the prostate, Semin. Oncol., 20 (Suppl. 2) (1993) 34-37.
35. Clavel, M., Management of breast cancer with bone metastases, Bone, 12 (Suppl. 1) (1991) S11-S12.
36. Cole, D.J., A randomized trial of a single treatment versus conventional fractionation in the palliative radiotherapy of painful bone pain, Clin. Oncol., 1 (1989) 59-62.
37. Coleman, R.E. and Rubens, R.D., Bone metastases and breast cancer, Cancer Treat Rev., 12 (1985) 251-270.
38. Collinson, M. and Tyrrell, C., Treatment of bone pain with bisphosphonates, Eur. J. Palliat. Care, 1 (1994) 175-177.
39. Cooper, M.G., Keneally, J.P. and Kinchington, D., Continuous brachial plexus neural blockade in a child with intractable cancer pain, J. Pain Symptom Manage., 9 (1994) 277-281.
40. Coyle, N., Adelhardt, J., Foley, K.M. and Portenoy, R.K., Character of terminal illness in the advanced cancer patient: pain and other symptoms during the last four weeks of life, J. Pain Symptom Manage., 5 (1990) 83-93.
41. Dearnaley, D.P., Cancer of the prostate, Br. Med. J., 308 (1994) 780-784.
42. Dearnaley, D.P., Bayly, R,J., A'Hern, R.P. et al., Palliation of bone metastases in prostate cancer, Hemibody irradiation or strontium-89, Clin. Oncol., 4 (1992) 101-107.
43. De Conno, F., Ripamonti, C., Sbanotto, A., Saita, L., Zecca, E. and Ventafridda, V., The pharmacological management of cancer pain, Ann. Oncol., 4 (1993) 187-193.
44. Du Pen, S.L., Kharasch, E.D., Williams, A. et al., Chronic bupivacaineopioid infusion in intractable cancer pain, Pain, 49 (1992) 293-300.
45. Eilon, G. and Mundy, G.R., Direct resorption of bone by human breast cancer cells in vitro, Nature, 276 (1978) 726-728.
46. Eisenberg, E., Berkey, C.S., Carr, D.B., Mosteller, F. and Chalmers, T.C., Efficacy and safety of nonsteroidal antiinflammatory drugs for cancer pain, J. Clin. Oncol., 12 (1994) 2756-2765.
47. Emery, S.E., Brazinski, M.S., Koka, A., Bensuan, J.S. and Stevenson, S., The biological and biomechanical effects of irradiation on anterior spinal bone grafts in a canine model, J. Bone Joint Surg., 76-A (1994) 540-548.
48. Ernst, D.S., MacDonald, R.N., Paterson, A.H.G., Jensen, J. and Bruera, E., A double-blind, cross over trial of IV clodronate in metastatic bone pain, J. Pain Symptom Manage., 7 (1992) 4-11.
49. Fallon, M.T. and O'Neill, W.M., Spinal surgery of metastatic back pain: three case reports, Palliat. Med., 7 (1993) 235-238.
50. Farcombe, M.L., Symptom control in a regional cancer center: an innovative outpatient approach, J. Palliat. Care, 7 (1991) 21-25.
51. Ferrer-Brechner, T., Rational management of cancer-related pain. In: R.P. Ray (Ed), Practical Management of Pain, Year Book Medical Publishers Inc., Chicago, 1986, pp. 312-328.
52. Fidler, M., Incidence of fracture through metastases in long bones, Acta Orthop. Scand., 52 (1981) 623-627.
53. Fidler, M.W., Radical resection of vertebral body tumours, J. Bone Joint Surg, 76-B (1994) 765-772.
54. Fidler, I.J. and Radinsky, R., Genetic control of cancer metastasis, J. Natl. Cancer Inst., 82 (1990) 160-168.
55. Fleisch, H., Bisphosphonates; Pharmacology and use in the treatment of tumour-induced hypercalcaemic and metastatic bone disease, Drugs, 42 (1991) 919-944.
56. Foley, K.M., Pain assessment and cancer pain syndromes. In: D. Doyle, G.W. Hanks and N. MacDonald (Eds.), Oxford Textbook of Palliative Medicine, Oxford Medical Publications, Oxford, 1993, pp. 148-165.
57. Frassica, F.J., Gitelis, S. and Sim, F.H., Metastatic bone disease: general principles, pathophysiology, evaluation, and biopsy, Instr. Course Lect., 41 (1992) 293-300.
58. Front, D., Schneck, S.O., Frankel, A. et al., Bone metastases and bone pain in breast cancer, J. Am. Med. Assoc., 242 (1979) 1747-1748.
59. Gaich, G. and Burtis, W.J., The diagnosis and treatment of malignancy-associated hypercalcaemia, Endocriniologist, 1 (1991) 371-379.
60. Galasko, C.S.B., Mechanism of bone destruction in the development of skeletal metastases, Nature, 263 (1986) 507-508.
61. Galasko, C.S.B., Orthopaedic principles and management. In: D. Doyle, G.W. Hanks and N. MacDonald (Eds.), Oxford Textbook of Palliative Medicine, Oxford Medical Publications, Oxford, 1993, pp. 274-282.
62. Gertz, B.J., Holland, S.D., Kline, W.F. et al., Studies of the oral bioavailability of alendronate, Clin. Pharmacol. Ther., 58 (1995) 288-298.
63. Glover, D., Lipton, A., Keller, A. et al., Intravenous pamidronate disodium treatment of bone metastases in patients with breast cancer, Cancer, 74 (1994) 2949-2955.
64. Harrington, K.D., Metastatic disease of the spine, J. Bone Joint Surg. Am., 68 (1986) 1110-1115.
65. Harrington, K.D., Orthopedic Management of Metastatic Bone Disease, C.V. Mosby, St Louis, 1988.
66. Hanks, G.W., Portenoy, R.K., MacDonald, N. and O'Neill, W., Difficult pain problems. In: D. Doyle, G.W. Hanks and N. MacDonald (Eds.), Oxford Textbook of Palliative Medicine, Oxford Medical Publications, Oxford, 1993, pp. 257-274.
67. Hindley, A.C., Hill, A.B., Leyland, M.J. et al., A double-blind controlled trial of salmon calcitonin in pain due to malignancy, Cancer Chemother. Pharmacol., 9 (1982) 71-74.
68. Hosain, F. and Spencer, R.P., Radiopharmaceuticals for palliation of metastatic osseous lesions: biologic and physical background, Semin. Nucl. Med., 22 (1992) 11-16.
69. Hoskin, P.J., Radiotherapy in symptom management. In: D. Doyle, G.W. Hanks and N. MacDonald (Eds.), Oxford Textbook of Palliative Medicine, Oxford Medical Publications, Oxford, 1993, pp. 117-129.
70. Hoskin, P.J., Using radioisotopes for bone metastases, Eur. J. Palliat. Care, 1 (1994) 78-82.
71. Hoskin, P.J., Radiotherapy for bone pain, Pain, 63 (1995a) 137-139.
72. Hoskin, P.J., Radiotherapy in the management of bone pain, Clin. Orthopaed. Res., 312 (1995b) 105-119.
73. Hoskin, P.J., Price, P., Easton, D. et al., A prospective randomised trial of 4 Gy or 8 Gy single doses in the treatment of metastatic bone pain, Radiother. Oncol., 23 (1991) 74-78.
74. Hoy, A.M., Radiotherapy, chemotherapy and hormone therapy: treatment for pain. In: P.D. Wall and R. Melzack (Eds.), Textbook of Pain, Churchill Livingstone, Edinburgh, 1989, pp. 966-978.
75. Ingham, J., Beveridge, A. and Cooney, N.J., The management of spinal cord compression in patients with advanced malignancy, J. Pain Symptom Manage., 8 (1993) 1-6.
76. Ischia, S., Ischia, A., Luzzani, A., Toscano, D. and Steele, A., Results up to death in the treatment of persistent cervico-thoracic (Pancoast) and thoracic malignant pain by unilateral percutaneous cervical cordotomy, Pain, 21 (1985) 339-355.
77. Johnson, J.R. and Miller, A.J., The efficacy of choline magnesium trisalicylate (CMT) in the management of metastatic bone pain: a pilot study, Palliat. Med., 8 (1994) 129-135.
78. Kanis, J.A., McCloskey, E.V. and Paterson, A.H.G., Diphosphonates in hypercalcaemia due to malignancy, Lancet, 335 (1990) 170-171.
79. Kanis, J.A., McCloskey, E.V., Taube, T. and O'Rourke, N., Rationale for the use of bisphosphonates in bone metastases, Bone, 12 (Suppl. 1) (1991) S13-S18.
80. Keene, J.S., Sellinger, D.S., McBeath, A.A. and Engber, W.D., Metastatic breast cancer in the femur: a search for the lesion at risk for fracture, Clin. Orthop., 203 (1986) 282-288.
81. Kellihan, M.J. and Mangino, P.D., Pamidronate, Ann. Pharmacother., 26 (1992) 1262-1269.
82. Koutsilieris, M., Rabbani, S.A., Bennett, H.P. and Goltzman, D., Characteristics of prostate-derived growth factors for cells of the osteoblast phenotype, J. Clin. Invest., 80 (1987) 941-946.
83. Kovacs, C.S., MacDonald, S.M., Chik, C.L. and Bruera, E., Hypercalcemia of malignancy in the palliative care patient: a treatment strategy, J. Pain Symptom Manage., 10 (1995) 224-232.
84. Kovner, F., Ron, I.G., Levita, M. and Chaitchik, S., Strontium-89 therapy in a patient with carcinoma of unknown origin and incurable pain from bone metastases, J. Pain Symptom Manage., 8 (1993) 47-51.
85. Kramer, J.A., Spinal cord compression in malignancy, Palliat. Med., 6 (1992) 202-211.
86. Krames, E.S., The chronic intraspinal use of opioid and anesthetic mixtures for the relief of intractable pain: when all else fails! Pain, 55 (1993) 1-4.
87. Kurman, M.R., Systemic therapy (chemotherapy) in the palliative treatment of cancer pain. In: R.B. Patt (Ed.), Cancer Pain, Lippincott, Philadelphia, PA, 1993, pp. 251-274.
88. Kylmala, T., Tamella, T., Ristelli, R. et al., Evaluation of oral clodronate on skeletal metastases with type I collagen metabolites, A controlled trial of the Finnish prostate cancer group, Eur. J. Cancer, 29A (1993) 821-825.
89. Lahtinen, R., Iaakso, M., Palva, I., Virkunssen, P. and Eloma, I., Randomised, placebo controlled multicentre trial of clodronate in multiple myeloma, Lancet, 340 (1991) 1049-1052.
90. Laing, A.H., Ackery, D.M., Bayly, R.J. et al., Strontium-89 chloride for pain palliation in prostatic skeletal malignancy, Br. J. Radiol., 64 (1991) 816-822.
91. Lamki, L.M., Haynie, T.P., Dexens, F., Johnson, D., Logothetis, C. and Von Eschenbach, A., Strontium-89 (Sr-89) in the palliative therapy of painful bone metastases: a phase II clinical study (abstract), J. Nucl. Med., 30 (1988) 448.
92. Latini, P., Maranzano, E., Ricci, S. et al., Role of radiotherapy in metastatic spinal cord compression: preliminary results from a prospective trial, Radiother. Oncol., 15 (1989) 227-233.
93. Liotta, L.A. and Stetler-Stevenson, W.G.D., Principles and Practice of Oncology, Lippincott, Philadelphia, PA, 1989, pp. 98-115.
94. Lipton, S., Percutaneous cordotomy. In: P.D. Wall and R. Melzack (Eds.), Textbook of Pain, Churchill Livingstone, Edinburgh, 1989, pp. 832-839.
95. Lote, K., Walloe, A. and Bjersand, A., Bone metastasis; Prognosis, diagnosis and treatment, Acta Radiol. Oncol., 25 (1986) 227-232.
96. MacDonald, N., Principles governing the use of cancer chemotherapy in palliative medicine. In: D. Doyle, G.W. Hanks and N. MacDonald (Eds.), Oxford Textbook of Palliative Medicine, Oxford Medical Publications, Oxford, 1993, pp. 105-117.
97. Massie, M.J., Anxiety, panic and phobias. In: J.C. Holland and J. Rowlands (Eds.), Handbook of Psychooncology: Psychological Care of The Patient With Cancer, Oxford, New York, 1989, 300-309.
98. Massie, M.J. and Holland, I.C., Depression and the cancer patient, J. Clin. Psychiatry, 51 (1990) 12-17.
99. Mauch, M.P. and Drew, M.A., Treatment of metastatic cancer to bone. In: V.T. De Vita, S. Hellman and S.A. Rosenberg (Eds.), Cancer, Principles and Practices of Oncology, Lippincott, Philadelphia, PA, 1989, pp. 2132-2141.
100. Maxon, H.R., Schroder, L.E., Hertzberg, V.S. et al., Re-186 (Sn) HEDP for treatment of painful osseous metastases: results of a double blind crossover comparison with placebo, J. Nucl. Med., 32 (1991) 1877-1881.
101. Maxon, H.R., Thomas, S.R., Hertzberg, V.S. et al., Rhenium, 186 hydroxyethilidene diphosphonate for the treatment of painful osseous metastases, Semin. Nucl. Med., 22 (1992) 33-40.
102. McCloskey, E.V., Yates, A.J.P., Beneton, M.N.C. et al., Comparative effects of intravenous diphosphonates on calcium and skeletal metabolism in man, Bone, 8 (Suppl. 1) (1987) S35-S41.
103. McCormack, K., Non-steroidal anti-inflammatory drugs and spinal nociceptive processing, Pain, 59 (1994) 9-43.
104. McEwan, A.J.B., Amyotte, G.A., McGowan, D.G. et al., A retrospective analysis of the cost effectiveness of treatment with metastron in patients with prostate cancer metastatic to bone, Eur. Urol., 26 (Suppl. 1) (1994) 26-31.
105. Mellette, S.J. and Blunk, K.L., Cancer rehabilitation, Semin. Oncol., 21 (1994) 779-782.
106. Mercadante, S., What is the definition of breakthrough pain? Pain, 45 (1991) 45-107.
107. Mercadante, S., Prevalence, causes and mechanisms of pain in homecare patients with advanced cancer, Pain Clin., 7 (1994a) 131-136.
108. Mercadante, S., Intrathecal morphine and bupivacaine in advanced cancer pain patients implanted at home, J. Pain Symptom Manage., 9 (1994b) 201-207.
109. Mercadante, S., Analgesic blocks in palliative care, Eur. J. Palliat. Care, 2 (1995) 103-106.
110. Mercadante, S., Maddaloni, S., Roccella, S. and Salvaggio, L., Predictive factors in advanced cancer pain treated only by analgesics, Pain, 50 (1992) 151-155.
111. Mercadante, S., Sapio, M. and Villari, P., Suprascapular nerve block by catheter for breakthrough shoulder cancer pain, Reg. Anesth., 20 (1995) 343-346.
112. Merlini, G., Parrinello, G.A. and Paccinini, L., Long-term effects of parenteral dichloromethylene bisphosphonate (C12 MBP) on bone disease of myeloma patients treated with chemotherapy, Haematol. Oncol., 8 (1990) 23-30.
113. Mertens, W.C., Radionuclide therapy of bone metastases: prospects for enhancement of therapeutic efficacy, Semin. Oncol., 20 (1993) 49-55.
114. Mertens, W.C., Reid, R.H., Porter, A.T. et al., Recent advances in radio-nuclide therapy of bone metastases. In: L.M. Freeman (Ed.), Nuclear Medicine Annual, 1992, Raven Press, New York, 1992, pp. 69-82.
115. Mirels, H., Metastatic disease in long bones, Clin. Orthop., 249 (1989) 256-264.
116. Mithal, N., Needham, P.R. and Hoskin, P.J., Retreatment with radio-therapy for painful bone metastases, Int. J. Radiation Oncol. Biol. Phys., 29 (1994) 1011-1014.
117. Morris, J.N., Mor, V., Goldberg, R.J. et al., The effect of treatment setting and patient characteristics of pain in terminal cancer patients: a report from the National Hospice Study, J. Chronic Dis., 39 (1986) 27-35.
118. Mundy, G.R., Bone resorption and turnover in health and disease, Bone, 8 (Suppl. 1) (1987) S9-S16.
119. Mundy, G.R., Mechanisms of osteolytic bone destruction, Bone, 12 (Suppl. 1) (1991) S1-S6.
120. Myers, D.P., Lema, M.J., de Leon-Casasola, O.A. and Bacon, D.R., Interpleural analgesia for the treatment of severe cancer pain in terminally ill patients, J. Pain Symptom Manage., 8 (1993) 505-510.
121. Nagaro, T., Amakawa, K., Yamauchi, Y. et al., Percutaneous cervical cordotomy and subarachnoid phenol block using fluoroscopy in pain control of costopleural syndrome, Pain, 58 (1994) 325-330.
122. Namer, M., Clinical consequences of osteolytic bone metastases, Bone, 12 (Suppl. 1) (1991) S7.
123. Needham, P.R. and Hoskin, P.J., Radiotherapy for painful bone metastases, Palliat. Med., 8 (1994) 95-104.
124. Nielsen, O.S., Munro, A.J. and Tannock, I.F., Bone metastasis: pathophysiology and management policy, J. Clin. Oncol., 9 (1991) 509-524.
125. Nitescu, P., Appelgren, L., Linder, L.E. et al., Epidural versus intrathecal morphine-bupivacaine: assessment of consecutive treatments in advanced cancer pain, J. Pain Symptom Manage., 5 (1990) 18-26.
126. Nussbaum, S.R., Warrell, R.P., Rude, R. et al., Dose-response study of alendronate sodium for the treatment of cancer-associated hypercalcemia, J. Clin. Oncol., 11 (1993) 1618-1623.
127. Oster, M.W., Vizel, M. and Turgeon, L.R., Pain of terminal cancer patients, Arch. Intern. Med., 138 (1978) 1801-1802.
128. Paterson, A.H.G., Ernst, D.S., Powle, T.J. et al., Treatment of skeletal disease in breast cancer with clodronate, Bone, 12 (Suppl. 1) (1991) S25-S30.
129. Portenoy, R.K., Cancer pain management, Semin. Oncol., 20 (Suppl. 1) (1993) 19-35.
130. Portenoy, R.K., Galer, B.S., Salamon, O. et al., Identification of epidural neoplasm radiography and bone scintigraphy in the symptomatic and asymptomatic spine, Cancer, 64 (1989) 2207-2213.
131. Portenoy, R.K. and Hagen, N., Breakthrough pain; Definition, prevalence and characteristics, Pain, 41 (1990) 273-283.
132. Porter, A.T., McEvan, A.J.B., Powe, J.E. et al., Results of a randomized phase III trial to evaluate the efficacy of strontium-89 adjuvant to local field external beam irradiation in the management of endocrine resistant metastatic prostate cancer, Int. J. Radiat. Oncol. Biol. Phys., 25 (1993) 805-813.
133. Poulson, H.S., Nielsen, O.S., Klee, M. et al., Palliative irradiation of bone metastases, Cancer Treat. Rev., 16 (1989) 41-48.
134. Poulter, C.A., Cosmatos, D., Rubin, P. et al., A report of RTOG 8206: a phase III study of whether the addition of single dose hemibody irradiation to standard fractioned local field irradiation is more effective than local field irradiation alone in the treatment of symptomatic osseous metastases, J. Radiat. Oncol. Biol. Phys., 23 (1992) 207-214.
135. Powles, T., Clodronate: the potential for the future, Bone, 12 (Suppl. 1) (1991) S43-S44.
136. Price, P., Hoskin, P.J., Easton, D. et al., Prospective randomised trial of single and multifraction radiotherapy schedules in the treatment of painful bony metastases, Radiother. Oncol., 6 (1986) 247-255.
137. Ralston, S.H., Management of cancer-associated hypercalcaemia, Eur. J. Palliat. Care, 1 (1994) 170-174.
138. Ralston, S.H., Alzaid, A.A., Gardner, M.D. and Boyle, I.T., Treatment of cancer-associated hypercalcaemia with combined aminohydroxipropylidene diphosphonate and calcitonin, Br. Med. J., 292 (1986) 1549-1550.
139. Robertson, A.G., Reed, N.S. and Ralston, S.H., Effect of oral clodronate on metastatic bone pain: a double-blind, placebo-controlled study, J. Clin. Oncol., 13 (1995) 2427-2430.
140. Robinson, R.G., Spicer, J.A., Preston, D.F., Wegst, A.V. and Martin, N.L., Treatment of metastatic bone pain with strontium-89, Nucl. Med. Biol., 14 (1987) 219-222.
141. Rosier, R.N., Orthopedic management of cancer pain. In: R.B. Platt (Ed.), Cancer Pain, J.B Lippincott, Philadelphia, 1993, pp. 461-468.
142. Samuelsson, H. and Hedner, T., Pain characterization in cancer patients and the analgesic response to epidural morphine, Pain, 46 (1991) 3-8.
143. Sandeman, T.F., Budd, R.S. and Martin, J.J., Samarium 153 labeled EDTMP for bone metastases from cancer of the prostate, Clin. Oncol., 4 (1992) 160-164.
144. Sato, S., Yamashita, S., Iwai, M., Mizuyama, K. and Satsumae, T., Continuous interscalene block for cancer pain, Reg. Anesth., 19 (1994) 73-75.
145. Scher, H.I. and Chung, W.K., Bone metastases: improving the therapeutic index, Semin. Oncol., 21 (1994) 630-656.
146. Silverstein, E.B., The treatment of painful osseous metastases with phosphorus-32-labeled phosphates, Semin. Oncol., 20 (Suppl. 2) (1993) 10-21.
147. Smoker, W.R.K., Godersky, J.C., Knutzon, R.K. et al., The role of MR imaging in evaluating metastatic spinal disease, Am. J. Nucl. Radiol. 8 (1987) 901-908.
148. Sundaresan, N., DiGiacinto, G.V., Krol, G. and Hughes, J.E.O., Spondylectomy for malignant tumors of the spine, J. Clin. Oncol., 7 (1989) 1485-1495.
149. Swarm, R.A. and Cousins, M.J., Anaesthetic techniques for pain control. In: D. Doyle, G.W. Hanks and N. MacDonald (Eds.), Oxford Textbook of Palliative Medicine, Oxford Medical Publications, Oxford, 1993, pp. 204-221.
150. Tannock, I., Gospodarowicz, M., Meakin, W. et al., Treatment of metastatic prostatic cancer with low dose prednisone: evaluation of pain and quality of life as pragmatic indices of response, J. Clin. Oncol., 7 (1989) 590-597.
151. Tasker, R.R., Neurosurgical and neuroaugmentative intervention. In: R.B. Patt (Ed.), Cancer Pain, J.B Lippincott, Philadelphia, 1993, pp. 471-500.
152. Thiebaud, D., Leyvraz, S., von Fledner, V. et al., Treatment of bone métastases from breast cancer and myeloma with pamidronate, Eur. J. Cancer, 27 (1991) 37-41.
153. Thompson, J. and Regnard, C., Managing pain in advanced cancer; a flow diagram, Palliat. Med., 6 (1992) 329-335.
154. Thurlimann, B., Progress in the treatment and palliation of advanced breast cancer: does the dose of pamidronate determine its effect? Ann. Oncol., 5 (Suppl. 7) (1994) 45-47.
155. Thurlimann, B., Morant, R., Jungi, W.F. and Radziwill, A., Pamidronate for pain control in patients with malignant osteolytic bone disease: a prospective dose-effect study, Support Care Cancer, 2 (1994) 61-65.
156. Tyrrel, C.J., Bruning, P.P., May-Levin, F. et al., Role of pamidronate in the management of bone metastases from breast cancer: results of a non-comparative multicentre phase 2 trial, Ann. Oncol., 5 (Suppl. 7) (1994) S37-S40.
157. Tubiana-Hulin, M., Incidence, prevalence and distribution of bone metastases, Bone, 12 (Suppl. 1) (1991) S9-S10.
158. Twycross, R.G., Management of pain in skeletal metastases, Clin. Orthopaed. Related Res., 312 (1995) 187-196.
159. Twycross, R.G. and Fairfield, S., Pain in far-advanced cancer, Pain, 14 (1982) 303-310.
160. van Holten-Verzantvoort, A.T.M., Zwindermann, A.H., Aaronson, N.K. et al., The effect of supportive pamidronate treatment on aspects of quality of life of patients with advanced breast cancer, Eur. J. Cancer, 27 (1991) 544-549.
161. van Holten-Verzantvoort, A.T.M., Krön, H.M., Bijvoet, O.L. et al., Palliative pamidronate treatment in patients with bone metastases from breast cancer, J. Clin. Oncol., 11 (1993) 491-498.
162. Ventafridda, V., Tamburini, M., Caraceni, A., De Conno, F. and Naldi, F., A validation study of the WHO method for cancer pain relief, Cancer, 59 (1987) 850-856.
163. Wally, B.A. and Hagen, N.A., The epidemiology of cancer pain, Pain Digest, 5 (1995) 237-244.
164. Warrell, R.P., Murphy, W.K., Schulman, P., O'Dwyer, P.J. and Heller, G., A randomized double blind study of gallium nitrate compared with etidronate for acute control of cancer-related hypercalcemia, J. Clin. Oncol., 9 (1991) 1467-1475.
165. Watanabe, S. and Bruera, E., Corticosteroids as adjuvant analgesics, J. Pain Symptom Manage., 9 (1994) 442-445.
166. Wood, B.C., Hormone treatments in the common hormone-dependent carcinomas, Palliat. Med., 7 (1993) 257-272.
167. Woodham, M.J. and Hanna, M., Psoas compartment block in malignant pain, Pain Clin., 2 (1988) 219-224.
168. World Health Organization, Cancer Pain Relief, Geneva, 1984.
169. Zech, D.F.J., Grond, S., Lynch, J., Hertel, D. and Lebemann, K.A., Validation of World Health Organization guidelines for cancer pain relief: a 10-year prospective study, Pain, 63 (1995) 65-76.