Pamidronate decreases tumor-induced osteoclastogenesis in osteopetrotic mice

Journal of Orthopaedic Research

Volumn 19, Issue 4, 2001, Pages 554-558

  Clohisy, Denis R ^a   O'Keefe, Patrick F ^a   Ramnaraine, Margaret L ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; TUMORS;

SKELETAL COMPLICATIONS;

DISEASES;

PAMIDRONIC ACID; PLACEBO; SODIUM CHLORIDE;

ALBERS SCHOENBERG DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE DISEASE; BONE TUMOR; CELL COUNT; CONTROLLED STUDY; DRUG MECHANISM; MOUSE; NONHUMAN; OSTEOCLAST; OSTEOLYSIS; OSTEOSARCOMA; PRIORITY JOURNAL; PROMYELOCYTE; STEM CELL;

EID: 0034926222     PISSN: 07360266     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0736-0266(00)00065-6     Document Type: Article

References (17)

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3. Osteoclast formation during tumor osteolysis does not require proliferating osteoclast precursor cells
4. Osteoclasts are required for bone tumors to grow and destroy bone
5. Efficacy of pamidronate in reducing skeletal complications in patients with breast cancer and lytic bone metastases
6. Bisphosphonates promote apoptosis in murine osteoclasts in vitro and in vivo
7. Increased growth rate and tumor burden of spontaneously metastatic Walker 256 cancer cells in the skeleton of bisphosphonate-treated rats
8. Nitrogen-containing bisphosphonates inhibit the mevalonate pathway and prevent post-translational prenylation of GTP-binding proteins, including ras
9. Evaluation of mutant mouse production by mice that are heterogenous for the M-CSF/op gene
10. Bisphosphonates induce apoptosis in mouse macrophage-like cells in vitro by a nitric oxide-independent mechanism
11. Bisphosphonate risedronate reduces metastatic human breast cancer burden in bone in nude mice
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13. Bisphosphonate action alendronate localization in rat bone and effects on osteoclast ultrastructure
14. Osteoblastic cells are involved in osteoclast formation
15. Cytochemical methods for the detection of apoptosis
16. Compactin suppresses bone resorption by inhibiting the fusion of prefusion osteoclasts and disrupting the actin ring in osteoclasts
17. Inhibition of osteolytic bone metastasis of breast cancer by combined treatment with the bisphosphonate ibandronate and tissue inhibitor of the matrix metalloproteinase-2