Skeletal localization and neutralization of the SDF-1(CXCL12)/CXCR4 axis blocks prostate cancer metastasis and growth in osseous sites in vivo

Journal of Bone and Mineral Research

Volumn 20, Issue 2, 2005, Pages 318-329

  Sun, Yan Xi ^a   Schneider, Abraham ^a   Jung, Younghun ^a   Wang, Jianhua ^a   Dai, Jinlu ^b   Wang, Jingcheng ^a   Cook, Kevin ^c   Osman, Nadir I ^b   Koh Paige, Amy J ^a   Shim, Hyusuk ^d,e   Pienta, Kenneth J ^b   Keller, Evan T ^b   McCauley, Laurie K ^a,b   Taichman, Russell S ^a  

^a UNIVERSITY OF MICHIGAN SCHOOL OF DENTISTRY   (United States)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF MICHIGAN   (United States)

^d EMORY UNIVERSITY   (United States)

^e EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Bone; Chemokine; Marrow; Metastasis; Prostate cancer

Indexed keywords

CHEMOKINE; CHEMOKINE RECEPTOR CXCR4; IMMUNOGLOBULIN G; MESSENGER RNA; MONOCLONAL ANTIBODY; NEUTRALIZING ANTIBODY; POLYCLONAL ANTIBODY; STROMAL CELL DERIVED FACTOR 1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE MARROW; BONE METASTASIS; CANCER CELL CULTURE; CANCER LOCALIZATION; CONTROLLED STUDY; CYTOKINE RELEASE; DIAPHYSIS; ENZYME LINKED IMMUNOSORBENT ASSAY; GROWTH PLATE; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; METAPHYSIS; MOUSE; NONHUMAN; PROSTATE CANCER; PROTEIN EXPRESSION; TUMOR VOLUME;

AMINO ACIDS; ANIMALS; BONE AND BONES; BONE MARROW CELLS; BONE NEOPLASMS; CALCIUM; CELL LINE, TUMOR; CELL PROLIFERATION; CHEMOKINES, CXC; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; MALE; MICE; MICE, INBRED C57BL; MICE, NUDE; NEOPLASM METASTASIS; NEOPLASM TRANSPLANTATION; PEPTIDES; PROSTATIC NEOPLASMS; RECEPTORS, CXCR4; RNA, MESSENGER; TISSUE DISTRIBUTION;

EID: 19944433608     PISSN: 08840431     EISSN: None     Source Type: Journal    
DOI: 10.1359/JBMR.041109     Document Type: Article

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