-
1
-
-
82255175382
-
Cardiac stem cells in patients with ischaemic cardiomyopathy (SCIPIO): Initial results of a randomised phase 1 trial
-
Bolli R, Chugh AR, D?Amario D, et al. Cardiac stem cells in patients with ischaemic cardiomyopathy (SCIPIO): initial results of a randomised phase 1 trial. Lancet. 2011;378:1847-1857.
-
(2011)
Lancet
, vol.378
, pp. 1847-1857
-
-
Bolli, R.1
Chugh, A.R.2
Damario, D.3
-
2
-
-
84866458852
-
Administration of cardiac stem cells in patients with ischemic cardiomyopathy: The SCIPIO trial: Surgical aspects and interim analysis of myocardial function and viability by magnetic resonance
-
Chugh AR, Beache GM, Loughran JH, Mewton N, Elmore JB, Kajstura J, Pappas P, Tatooles A, Stoddard MF, Lima JA, Slaughter MS, Anversa P, Bolli R. Administration of cardiac stem cells in patients with ischemic cardiomyopathy: the SCIPIO trial: surgical aspects and interim analysis of myocardial function and viability by magnetic resonance. Circulation. 2012;126:S54-S64.
-
(2012)
Circulation
, vol.126
-
-
Chugh, A.R.1
Beache, G.M.2
Loughran, J.H.3
Mewton, N.4
Elmore, J.B.5
Kajstura, J.6
Pappas, P.7
Tatooles, A.8
Stoddard, M.F.9
Lima, J.A.10
Slaughter, M.S.11
Anversa, P.12
Bolli, R.13
-
3
-
-
79151471175
-
Paracrine mechanisms of stem cell reparative and regenerative actions in the heart
-
Mirotsou M, Jayawardena TM, Schmeckpeper J, Gnecchi M, Dzau VJ. Paracrine mechanisms of stem cell reparative and regenerative actions in the heart. J Mol Cell Cardiol. 2011;50:280-289.
-
(2011)
J Mol Cell Cardiol
, vol.50
, pp. 280-289
-
-
Mirotsou, M.1
Jayawardena, T.M.2
Schmeckpeper, J.3
Gnecchi, M.4
Dzau, V.J.5
-
4
-
-
84884773562
-
-
List of top selling drugs for 2012 Available at Accessed May 4, 2013
-
List of top selling drugs for 2012. Available at: http://www.drugs.com/ stats/top100/sales. Accessed May 4, 2013.
-
-
-
-
5
-
-
11144355354
-
Pravastatin or Atorvastatin Evaluation and Infection Therapy-Thrombolysis in Myocardial Infarction 22 Investigators. Intensive versus moderate lipid lowering with statins after acute coronary syndromes
-
Cannon CP, Braunwald E, McCabe CH, Rader DJ, Rouleau JL, Belder R, Joyal SV, Hill KA, Pfeffer MA, Skene AM; Pravastatin or Atorvastatin Evaluation and Infection Therapy-Thrombolysis in Myocardial Infarction 22 Investigators. Intensive versus moderate lipid lowering with statins after acute coronary syndromes. N Engl J Med. 2004;350:1495-1504.
-
(2004)
N Engl J Med
, vol.350
, pp. 1495-1504
-
-
Cannon, C.P.1
Braunwald, E.2
McCabe, C.H.3
Rader, D.J.4
Rouleau, J.L.5
Belder, R.6
Joyal, S.V.7
Hill, K.A.8
Pfeffer, M.A.9
Skene, A.M.10
-
6
-
-
56749106312
-
Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein
-
Ridker PM, Danielson E, Fonseca FA, Genest J, Gotto AM Jr, Kastelein JJ, Koenig W, Libby P, Lorenzatti AJ, MacFadyen JG, Nordestgaard BG, Shepherd J, Willerson JT, Glynn RJ; JUPITER Study Group. Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein. N Engl J Med. 2008;359:2195-2207.
-
(2008)
N Engl J Med
, vol.359
, pp. 2195-2207
-
-
Ridker, P.M.1
Danielson, E.2
Fonseca, F.A.3
Genest, J.4
Gotto Jr., A.M.5
Kastelein, J.J.6
Koenig, W.7
Libby, P.8
Lorenzatti, A.J.9
Macfadyen, J.G.10
Nordestgaard, B.G.11
Shepherd, J.12
Willerson, J.T.13
Glynn, R.J.14
Study Group, J.15
-
7
-
-
20144373281
-
CLARITY-TIMI 28 Investigators. Addition of clopidogrel to aspirin and fibrinolytic therapy for myocardial infarction with STsegment elevation
-
Sabatine MS, Cannon CP, Gibson CM, López-Sendón JL, Montalescot G, Theroux P, Claeys MJ, Cools F, Hill KA, Skene AM, McCabe CH, Braunwald E; CLARITY-TIMI 28 Investigators. Addition of clopidogrel to aspirin and fibrinolytic therapy for myocardial infarction with STsegment elevation. N Engl J Med. 2005;352:1179-1189.
-
(2005)
N Engl J Med
, vol.352
, pp. 1179-1189
-
-
Sabatine, M.S.1
Cannon, C.P.2
Gibson, C.M.3
López-Sendón, J.L.4
Montalescot, G.5
Theroux, P.6
Claeys, M.J.7
Cools, F.8
Hill, K.A.9
Skene, A.M.10
McCabe, C.H.11
Braunwald, E.12
-
8
-
-
67650569135
-
Neuregulin1/ErbB4 signaling induces cardiomyocyte proliferation and repair of heart injury
-
Bersell K, Arab S, Haring B, Kühn B. Neuregulin1/ErbB4 signaling induces cardiomyocyte proliferation and repair of heart injury. Cell. 2009;138:257-270.
-
(2009)
Cell
, vol.138
, pp. 257-270
-
-
Bersell, K.1
Arab, S.2
Haring, B.3
Kühn, B.4
-
9
-
-
18644361997
-
Pharmacokinetic and pharmacodynamic considerations in the development of therapeutic proteins
-
Mahmood I, Green MD. Pharmacokinetic and pharmacodynamic considerations in the development of therapeutic proteins. Clin Pharmacokinet. 2005;44:331-347.
-
(2005)
Clin Pharmacokinet
, vol.44
, pp. 331-347
-
-
Mahmood, I.1
Green, M.D.2
-
12
-
-
75149183678
-
Glycosylation of therapeutic proteins: An effective strategy to optimize efficacy
-
Solá RJ, Griebenow K. Glycosylation of therapeutic proteins: an effective strategy to optimize efficacy. BioDrugs. 2010;24:9-21.
-
(2010)
BioDrugs
, vol.24
, pp. 9-21
-
-
Solá, R.J.1
Griebenow, K.2
-
13
-
-
0021818675
-
Filamentous fusion phage: Novel expression vectors that display cloned antigens on the virion surface
-
Smith GP. Filamentous fusion phage: novel expression vectors that display cloned antigens on the virion surface. Science. 1985;228:1315-1317.
-
(1985)
Science
, vol.228
, pp. 1315-1317
-
-
Smith, G.P.1
-
14
-
-
0030994634
-
Yeast surface display for screening combinatorial polypeptide libraries
-
Boder ET, Wittrup KD. Yeast surface display for screening combinatorial polypeptide libraries. Nat Biotechnol. 1997;15:553-557.
-
(1997)
Nat Biotechnol
, vol.15
, pp. 553-557
-
-
Boder, E.T.1
Wittrup, K.D.2
-
15
-
-
35148820656
-
Local delivery of protease-resistant stromal cell derived factor-1 for stem cell recruitment after myocardial infarction
-
Segers VF, Tokunou T, Higgins LJ, MacGillivray C, Gannon J, Lee RT. Local delivery of protease-resistant stromal cell derived factor-1 for stem cell recruitment after myocardial infarction. Circulation. 2007;116:1683-1692.
-
(2007)
Circulation
, vol.116
, pp. 1683-1692
-
-
Segers, V.F.1
Tokunou, T.2
Higgins, L.J.3
Macgillivray, C.4
Gannon, J.5
Lee, R.T.6
-
16
-
-
0026568164
-
Directed evolution of a protein: Selection of potent neutrophil elastase inhibitors displayed on M13 fusion phage
-
Roberts BL, Markland W, Ley AC, Kent RB, White DW, Guterman SK, Ladner RC. Directed evolution of a protein: selection of potent neutrophil elastase inhibitors displayed on M13 fusion phage. Proc Natl Acad Sci USA. 1992;89:2429-2433.
-
(1992)
Proc Natl Acad Sci USA
, vol.89
, pp. 2429-2433
-
-
Roberts, B.L.1
Markland, W.2
Ley, A.C.3
Kent, R.B.4
White, D.W.5
Guterman, S.K.6
Ladner, R.C.7
-
17
-
-
0017701219
-
Alteration of immunological properties of bovine serum albumin by covalent attachment of polyethylene glycol
-
Abuchowski A, van Es T, Palczuk NC, Davis FF. Alteration of immunological properties of bovine serum albumin by covalent attachment of polyethylene glycol. J Biol Chem. 1977;252:3578-3581.
-
(1977)
J Biol Chem
, vol.252
, pp. 3578-3581
-
-
Abuchowski, A.1
Van Es, T.2
Palczuk, N.C.3
Davis, F.F.4
-
18
-
-
0017388651
-
Effect of covalent attachment of polyethylene glycol on immunogenicity and circulating life of bovine liver catalase
-
Abuchowski A, McCoy JR, Palczuk NC, van Es T, Davis FF. Effect of covalent attachment of polyethylene glycol on immunogenicity and circulating life of bovine liver catalase. J Biol Chem. 1977;252:3582-3586.
-
(1977)
J Biol Chem
, vol.252
, pp. 3582-3586
-
-
Abuchowski, A.1
McCoy, J.R.2
Palczuk, N.C.3
Van Es, T.4
Davis, F.F.5
-
19
-
-
0024968835
-
A general method for site-specific incorporation of unnatural amino acids into proteins
-
Noren CJ, Anthony-Cahill SJ, Griffith MC, Schultz PG. A general method for site-specific incorporation of unnatural amino acids into proteins. Science. 1989;244:182-188.
-
(1989)
Science
, vol.244
, pp. 182-188
-
-
Noren, C.J.1
Anthony-Cahill, S.J.2
Griffith, M.C.3
Schultz, P.G.4
-
20
-
-
0037039298
-
Incorporation of azides into recombinant proteins for chemoselective modification by the Staudinger ligation
-
Kiick KL, Saxon E, Tirrell DA, Bertozzi CR. Incorporation of azides into recombinant proteins for chemoselective modification by the Staudinger ligation. Proc Natl Acad Sci USA. 2002;99:19-24.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 19-24
-
-
Kiick, K.L.1
Saxon, E.2
Tirrell, D.A.3
Bertozzi, C.R.4
-
21
-
-
0025827590
-
A tumor necrosis factor (TNF) receptor-IgG heavy chain chimeric protein as a bivalent antagonist of TNF activity
-
Peppel K, Crawford D, Beutler B. A tumor necrosis factor (TNF) receptor-IgG heavy chain chimeric protein as a bivalent antagonist of TNF activity. J Exp Med. 1991;174:1483-1489.
-
(1991)
J Exp Med
, vol.174
, pp. 1483-1489
-
-
Peppel, K.1
Crawford, D.2
Beutler, B.3
-
22
-
-
0029670957
-
Tumor necrosis factor-alpha and tumor necrosis factor receptors in the failing human heart
-
Torre-Amione G, Kapadia S, Lee J, Durand JB, Bies RD, Young JB, Mann DL. Tumor necrosis factor-alpha and tumor necrosis factor receptors in the failing human heart. Circulation. 1996;93:704-711.
-
(1996)
Circulation
, vol.93
, pp. 704-711
-
-
Torre-Amione, G.1
Kapadia, S.2
Lee, J.3
Durand, J.B.4
Bies, R.D.5
Young, J.B.6
Mann, D.L.7
-
23
-
-
0032515948
-
Tumor necrosis factoralpha confers resistance to hypoxic injury in the adult mammalian cardiac myocyte
-
Nakano M, Knowlton AA, Dibbs Z, Mann DL. Tumor necrosis factoralpha confers resistance to hypoxic injury in the adult mammalian cardiac myocyte. Circulation. 1998;97:1392-1400.
-
(1998)
Circulation
, vol.97
, pp. 1392-1400
-
-
Nakano, M.1
Knowlton, A.A.2
Dibbs, Z.3
Mann, D.L.4
-
24
-
-
0034625134
-
Endogenous tumor necrosis factor protects the adult cardiac myocyte against ischemic-induced apoptosis in a murine model of acute myocardial infarction
-
Kurrelmeyer KM, Michael LH, Baumgarten G, Taffet GE, Peschon JJ, Sivasubramanian N, Entman ML, Mann DL. Endogenous tumor necrosis factor protects the adult cardiac myocyte against ischemic-induced apoptosis in a murine model of acute myocardial infarction. Proc Natl Acad Sci USA. 2000;97:5456-5461.
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 5456-5461
-
-
Kurrelmeyer, K.M.1
Michael, L.H.2
Baumgarten, G.3
Taffet, G.E.4
Peschon, J.J.5
Sivasubramanian, N.6
Entman, M.L.7
Mann, D.L.8
-
25
-
-
0033614816
-
Safety and efficacy of a soluble P75 tumor necrosis factor receptor (Enbrel, etanercept) in patients with advanced heart failure
-
Deswal A, Bozkurt B, Seta Y, Parilti-Eiswirth S, Hayes FA, Blosch C, Mann DL. Safety and efficacy of a soluble P75 tumor necrosis factor receptor (Enbrel, etanercept) in patients with advanced heart failure. Circulation. 1999;99:3224-3226.
-
(1999)
Circulation
, vol.99
, pp. 3224-3226
-
-
Deswal, A.1
Bozkurt, B.2
Seta, Y.3
Parilti-Eiswirth, S.4
Hayes, F.A.5
Blosch, C.6
Mann, D.L.7
-
26
-
-
0035910002
-
Tumor necrosis factor antagonism with etanercept improves systemic endothelial vasoreactivity in patients with advanced heart failure
-
Fichtlscherer S, Rössig L, Breuer S, Vasa M, Dimmeler S, Zeiher AM. Tumor necrosis factor antagonism with etanercept improves systemic endothelial vasoreactivity in patients with advanced heart failure. Circulation. 2001;104:3023-3025.
-
(2001)
Circulation
, vol.104
, pp. 3023-3025
-
-
Fichtlscherer, S.1
Rössig, L.2
Breuer, S.3
Vasa, M.4
Dimmeler, S.5
Zeiher, A.M.6
-
27
-
-
11144355760
-
Targeted anticytokine therapy in patients with chronic heart failure: Results of the Randomized Etanercept Worldwide Evaluation (RENEWAL)
-
Mann DL, McMurray JJ, Packer M, et al. Targeted anticytokine therapy in patients with chronic heart failure: results of the Randomized Etanercept Worldwide Evaluation (RENEWAL). Circulation. 2004;109:1594-1602.
-
(2004)
Circulation
, vol.109
, pp. 1594-1602
-
-
Mann, D.L.1
McMurray, J.J.2
Packer, M.3
-
28
-
-
0027361432
-
Construction and initial characterization of a mouse-human chimeric anti-TNF antibody
-
Knight DM, Trinh H, Le J, Siegel S, Shealy D, McDonough M, Scallon B, Moore MA, Vilcek J, Daddona P. Construction and initial characterization of a mouse-human chimeric anti-TNF antibody. Mol Immunol. 1993;30:1443-1453.
-
(1993)
Mol Immunol
, vol.30
, pp. 1443-1453
-
-
Knight, D.M.1
Trinh, H.2
Le Siegel, J.S.3
Shealy, D.4
McDonough, M.5
Scallon, B.6
Moore, M.A.7
Vilcek, J.8
Daddona, P.9
-
29
-
-
0029004771
-
Chimeric anti-TNF-alpha monoclonal antibody cA2 binds recombinant transmembrane TNF-alpha and activates immune effector functions
-
Scallon BJ, Moore MA, Trinh H, Knight DM, Ghrayeb J. Chimeric anti-TNF-alpha monoclonal antibody cA2 binds recombinant transmembrane TNF-alpha and activates immune effector functions. Cytokine. 1995;7:251-259.
-
(1995)
Cytokine
, vol.7
, pp. 251-259
-
-
Scallon, B.J.1
Moore, M.A.2
Trinh, H.3
Knight, D.M.4
Ghrayeb, J.5
-
30
-
-
0038755661
-
Randomized, double-blind, placebo-controlled, pilot trial of infliximab, a chimeric monoclonal antibody to tumor necrosis factor-alpha, in patients with moderate-to-severe heart failure: Results of the anti-tnf therapy against congestive heart failure (ATTACH) trial
-
Chung ES, Packer M, Lo KH, Fasanmade AA, Willerson JT. Randomized, double-blind, placebo-controlled, pilot trial of infliximab, a chimeric monoclonal antibody to tumor necrosis factor-alpha, in patients with moderate-to-severe heart failure: results of the anti-tnf therapy against congestive heart failure (ATTACH) trial. Circulation. 2003;107:3133-3140.
-
(2003)
Circulation
, vol.107
, pp. 3133-3140
-
-
Chung, E.S.1
Packer, M.2
Lo, K.H.3
Fasanmade, A.A.4
Willerson, J.T.5
-
31
-
-
0034176934
-
Treatment of heart failure guided by plasma aminoterminal brain natriuretic peptide (N-BNP) concentrations
-
Troughton RW, Frampton CM, Yandle TG, Espiner EA, Nicholls MG, Richards AM. Treatment of heart failure guided by plasma aminoterminal brain natriuretic peptide (N-BNP) concentrations. Lancet. 2000;355:1126-1130.
-
(2000)
Lancet
, vol.355
, pp. 1126-1130
-
-
Troughton, R.W.1
Frampton, C.M.2
Yandle, T.G.3
Espiner, E.A.4
Nicholls, M.G.5
Richards, A.M.6
-
32
-
-
0022471069
-
Atrial natriuretic peptide elevation in congestive heart failure in the human
-
Burnett JC Jr, Kao PC, Hu DC, Heser DW, Heublein D, Granger JP, Opgenorth TJ, Reeder GS. Atrial natriuretic peptide elevation in congestive heart failure in the human. Science. 1986;231:1145-1147.
-
(1986)
Science
, vol.231
, pp. 1145-1147
-
-
Burnett Jr., J.C.1
Kao, P.C.2
Hu, D.C.3
Heser, D.W.4
Heublein, D.5
Granger, J.P.6
Opgenorth, T.J.7
Reeder, G.S.8
-
33
-
-
84870239189
-
Novel protein therapeutics for systolic heart failure: Chronic subcutaneous B-type natriuretic peptide
-
Chen HH, Glockner JF, Schirger JA, Cataliotti A, Redfield MM, Burnett JC Jr. Novel protein therapeutics for systolic heart failure: chronic subcutaneous B-type natriuretic peptide. J Am Coll Cardiol. 2012;60:2305-2312.
-
(2012)
J Am Coll Cardiol
, vol.60
, pp. 2305-2312
-
-
Chen, H.H.1
Glockner, J.F.2
Schirger, J.A.3
Cataliotti, A.4
Redfield, M.M.5
Burnett Jr., J.C.6
-
34
-
-
16344377117
-
Risk of worsening renal function with nesiritide in patients with acutely decompensated heart failure
-
Sackner-Bernstein JD, Skopicki HA, Aaronson KD. Risk of worsening renal function with nesiritide in patients with acutely decompensated heart failure. Circulation. 2005;111:1487-1491.
-
(2005)
Circulation
, vol.111
, pp. 1487-1491
-
-
Sackner-Bernstein, J.D.1
Skopicki, H.A.2
Aaronson, K.D.3
-
36
-
-
0037130758
-
Natriuretic peptide receptors and neutral endopeptidase in mediating the renal actions of a new therapeutic synthetic natriuretic peptide dendroaspis natriuretic peptide
-
Chen HH, Lainchbury JG, Burnett JC Jr. Natriuretic peptide receptors and neutral endopeptidase in mediating the renal actions of a new therapeutic synthetic natriuretic peptide dendroaspis natriuretic peptide. J Am Coll Cardiol. 2002;40:1186-1191.
-
(2002)
J Am Coll Cardiol
, vol.40
, pp. 1186-1191
-
-
Chen, H.H.1
Lainchbury, J.G.2
Burnett Jr., J.C.3
-
37
-
-
45449110992
-
Design, synthesis, and actions of a novel chimeric natriuretic peptide: CDNP
-
Lisy O, Huntley BK, McCormick DJ, Kurlansky PA, Burnett JC Jr. Design, synthesis, and actions of a novel chimeric natriuretic peptide: CDNP. J Am Coll Cardiol. 2008;52:60-68.
-
(2008)
J Am Coll Cardiol
, vol.52
, pp. 60-68
-
-
Lisy, O.1
Huntley, B.K.2
McCormick, D.J.3
Kurlansky, P.A.4
Burnett Jr., J.C.5
-
38
-
-
77649130274
-
CD-NP, a chimeric natriuretic peptide for the treatment of heart failure
-
Rose RA. CD-NP, a chimeric natriuretic peptide for the treatment of heart failure. Curr Opin Investig Drugs. 2010;11:349-356.
-
(2010)
Curr Opin Investig Drugs
, vol.11
, pp. 349-356
-
-
Rose, R.A.1
-
39
-
-
84884760305
-
-
Effects of chimeric natriuretic peptide versus bnp versus placebo in stable heart failure and moderate renal dysfunction Available at Accessed May 4 2013
-
Effects of chimeric natriuretic peptide versus bnp versus placebo in stable heart failure and moderate renal dysfunction. Available at: http://www.clinicaltrials.gov/ct2/show/NCT01407900.02/26/13. Accessed May 4, 2013.
-
-
-
-
40
-
-
0030829808
-
Overexpression of insulin-like growth factor-1 in mice protects from myocyte death after infarction, attenuating ventricular dilation, wall stress, and cardiac hypertrophy
-
Li Q, Li B, Wang X, Leri A, Jana KP, Liu Y, Kajstura J, Baserga R, Anversa P. Overexpression of insulin-like growth factor-1 in mice protects from myocyte death after infarction, attenuating ventricular dilation, wall stress, and cardiac hypertrophy. J Clin Invest. 1997;100:1991-1999.
-
(1997)
J Clin Invest
, vol.100
, pp. 1991-1999
-
-
Li, Q.1
Li, B.2
Wang, X.3
Leri, A.4
Jana, K.P.5
Liu, Y.6
Kajstura, J.7
Baserga, R.8
Anversa, P.9
-
41
-
-
0037143639
-
Low serum insulin-like growth factor i is associated with increased risk of ischemic heart disease: A population-based case-control study
-
Juul A, Scheike T, Davidsen M, Gyllenborg J, Jørgensen T. Low serum insulin-like growth factor I is associated with increased risk of ischemic heart disease: a population-based case-control study. Circulation. 2002;106:939-944.
-
(2002)
Circulation
, vol.106
, pp. 939-944
-
-
Juul, A.1
Scheike, T.2
Davidsen, M.3
Gyllenborg, J.4
Jørgensen, T.5
-
42
-
-
0028118369
-
Adverse effects of recombinant human insulin-like growth factor i in obese insulin-resistant type II diabetic patients
-
Jabri N, Schalch DS, Schwartz SL, Fischer JS, Kipnes MS, Radnik BJ, Turman NJ, Marcsisin VS, Guler HP. Adverse effects of recombinant human insulin-like growth factor I in obese insulin-resistant type II diabetic patients. Diabetes. 1994;43:369-374.
-
(1994)
Diabetes
, vol.43
, pp. 369-374
-
-
Jabri, N.1
Schalch, D.S.2
Schwartz, S.L.3
Fischer, J.S.4
Kipnes, M.S.5
Radnik, B.J.6
Turman, N.J.7
Marcsisin, V.S.8
Guler, H.P.9
-
44
-
-
33750550642
-
The role of growth hormone, insulin-like growth factor and somatostatin in diabetic retinopathy
-
Wilkinson-Berka JL, Wraight C, Werther G. The role of growth hormone, insulin-like growth factor and somatostatin in diabetic retinopathy. Curr Med Chem. 2006;13:3307-3317.
-
(2006)
Curr Med Chem
, vol.13
, pp. 3307-3317
-
-
Wilkinson-Berka, J.L.1
Wraight, C.2
Werther, G.3
-
45
-
-
84884765820
-
-
Evaluation of the safety and efficacy of using insulin-like growth factor-1 in patients with a heart attack (resus-ami) Available at Accessed May 4,2013
-
Evaluation of the safety and efficacy of using insulin-like growth factor-1 in patients with a heart attack (resus-ami). Available at: http://www.clinicaltrials.gov/ct2/show/NCT01438086.02/24/13. Accessed May 4, 2013.
-
-
-
-
46
-
-
84884798640
-
-
Treatment of the low igf-1 syndrome associated with chronic heart failure: a randomized, placebo-controlled, double-blind study (TOSCA2) Available at Accessed May, 4, 2013
-
Treatment of the low igf-1 syndrome associated with chronic heart failure: a randomized, placebo-controlled, double-blind study (TOSCA2). Available at: http://www.clinicaltrials.gov/ct2/show/NCT01235273.02/24/13. Accessed May 4, 2013.
-
-
-
-
47
-
-
44949233726
-
Engineering insulin-like growth factor-1 for local delivery
-
Tokunou T, Miller R, Patwari P, Davis ME, Segers VF, Grodzinsky AJ, Lee RT. Engineering insulin-like growth factor-1 for local delivery. FASEB J. 2008;22:1886-1893.
-
(2008)
FASEB J
, vol.22
, pp. 1886-1893
-
-
Tokunou, T.1
Miller, R.2
Patwari, P.3
Davis, M.E.4
Segers, V.F.5
Grodzinsky, A.J.6
Lee, R.T.7
-
48
-
-
80055104248
-
Engineered insulin-like growth factor-1 for improved smooth muscle regeneration
-
Lorentz KM, Yang L, Frey P, Hubbell JA. Engineered insulin-like growth factor-1 for improved smooth muscle regeneration. Biomaterials. 2012;33:494-503.
-
(2012)
Biomaterials
, vol.33
, pp. 494-503
-
-
Lorentz, K.M.1
Yang, L.2
Frey, P.3
Hubbell, J.A.4
-
49
-
-
33744501240
-
Local myocardial insulin-like growth factor 1 (IGF-1) delivery with biotinylated peptide nanofibers improves cell therapy for myocardial infarction
-
Davis ME, Hsieh PC, Takahashi T, Song Q, Zhang S, Kamm RD, Grodzinsky AJ, Anversa P, Lee RT. Local myocardial insulin-like growth factor 1 (IGF-1) delivery with biotinylated peptide nanofibers improves cell therapy for myocardial infarction. Proc Natl Acad Sci USA. 2006;103: 8155-8160.
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 8155-8160
-
-
Davis, M.E.1
Hsieh, P.C.2
Takahashi, T.3
Song, Q.4
Zhang, S.5
Kamm, R.D.6
Grodzinsky, A.J.7
Anversa, P.8
Lee, R.T.9
-
50
-
-
70349783458
-
Cardiac progenitor cells and biotinylated insulin-like growth factor-1 nanofibers improve endogenous and exogenous myocardial regeneration after infarction
-
Padin-Iruegas ME, Misao Y, Davis ME, Segers VF, Esposito G, Tokunou T, Urbanek K, Hosoda T, Rota M, Anversa P, Leri A, Lee RT, Kajstura J. Cardiac progenitor cells and biotinylated insulin-like growth factor-1 nanofibers improve endogenous and exogenous myocardial regeneration after infarction. Circulation. 2009;120:876-887.
-
(2009)
Circulation
, vol.120
, pp. 876-887
-
-
Padin-Iruegas, M.E.1
Misao, Y.2
Davis, M.E.3
Segers, V.F.4
Esposito, G.5
Tokunou, T.6
Urbanek, K.7
Hosoda, T.8
Rota, M.9
Anversa, P.10
Leri, A.11
Lee, R.T.12
Kajstura, J.13
-
51
-
-
7944230945
-
CXCR4-SDF-1 signalling, locomotion, chemotaxis and adhesion
-
Kucia M, Jankowski K, Reca R, Wysoczynski M, Bandura L, Allendorf DJ, Zhang J, Ratajczak J, Ratajczak MZ. CXCR4-SDF-1 signalling, locomotion, chemotaxis and adhesion. J Mol Histol. 2004;35:233-245.
-
(2004)
J Mol Histol
, vol.35
, pp. 233-245
-
-
Kucia, M.1
Jankowski, K.2
Reca, R.3
Wysoczynski, M.4
Bandura, L.5
Allendorf, D.J.6
Zhang, J.7
Ratajczak, J.8
Ratajczak, M.Z.9
-
52
-
-
0041327804
-
Effect of stromal-cell-derived factor 1 on stem-cell homing and tissue regeneration in ischaemic cardiomyopathy
-
Askari AT, Unzek S, Popovic ZB, Goldman CK, Forudi F, Kiedrowski M, Rovner A, Ellis SG, Thomas JD, DiCorleto PE, Topol EJ, Penn MS. Effect of stromal-cell-derived factor 1 on stem-cell homing and tissue regeneration in ischaemic cardiomyopathy. Lancet. 2003;362:697-703.
-
(2003)
Lancet
, vol.362
, pp. 697-703
-
-
Askari, A.T.1
Unzek, S.2
Popovic, Z.B.3
Goldman, C.K.4
Forudi, F.5
Kiedrowski, M.6
Rovner, A.7
Ellis, S.G.8
Thomas, J.D.9
Dicorleto, P.E.10
Topol, E.J.11
Penn, M.S.12
-
53
-
-
9344255481
-
Stromal cell-derived factor-1alpha plays a critical role in stem cell recruitment to the heart after myocardial infarction but is not sufficient to induce homing in the absence of injury
-
Abbott JD, Huang Y, Liu D, Hickey R, Krause DS, Giordano FJ. Stromal cell-derived factor-1alpha plays a critical role in stem cell recruitment to the heart after myocardial infarction but is not sufficient to induce homing in the absence of injury. Circulation. 2004;110:3300-3305.
-
(2004)
Circulation
, vol.110
, pp. 3300-3305
-
-
Abbott, J.D.1
Huang, Y.2
Liu, D.3
Hickey, R.4
Krause, D.S.5
Giordano, F.J.6
-
54
-
-
0034682885
-
Inflammation dampened by gelatinase A cleavage of monocyte chemoattractant protein-3
-
McQuibban GA, Gong JH, Tam EM, McCulloch CA, Clark-Lewis I, Overall CM. Inflammation dampened by gelatinase A cleavage of monocyte chemoattractant protein-3. Science. 2000;289:1202-1206.
-
(2000)
Science
, vol.289
, pp. 1202-1206
-
-
McQuibban, G.A.1
Gong, J.H.2
Tam, E.M.3
McCulloch, C.A.4
Clark-Lewis, I.5
Overall, C.M.6
-
55
-
-
0035941359
-
Matrix metalloproteinase activity inactivates the CXC chemokine stromal cell-derived factor-1
-
McQuibban GA, Butler GS, Gong JH, Bendall L, Power C, Clark-Lewis I, Overall CM. Matrix metalloproteinase activity inactivates the CXC chemokine stromal cell-derived factor-1. J Biol Chem. 2001;276:43503-43508.
-
(2001)
J Biol Chem
, vol.276
, pp. 43503-43508
-
-
McQuibban, G.A.1
Butler, G.S.2
Gong, J.H.3
Bendall, L.4
Power, C.5
Clark-Lewis, I.6
Overall, C.M.7
-
56
-
-
1642366238
-
Differential processing of stromal-derived factor-1alpha and stromal-derived factor-1beta explains functional diversity
-
De La Luz Sierra M, Yang F, Narazaki M, Salvucci O, Davis D, Yarchoan R, Zhang HH, Fales H, Tosato G. Differential processing of stromal-derived factor-1alpha and stromal-derived factor-1beta explains functional diversity. Blood. 2004;103:2452-2459.
-
(2004)
Blood
, vol.103
, pp. 2452-2459
-
-
De La Luz, S.M.1
Yang, F.2
Narazaki, M.3
Salvucci, O.4
Davis, D.5
Yarchoan, R.6
Zhang, H.H.7
Fales, H.8
Tosato, G.9
-
57
-
-
84884785701
-
-
Study to evaluate the safety and efficacy of jvs-100 administered to adults with critical limb ischemia Available at Accessed May 4,2013
-
Study to evaluate the safety and efficacy of jvs-100 administered to adults with critical limb ischemia. Available at: http://www.clinicaltrials.gov/ ct2/show/NCT01410331.02/24/13. Accessed May 4, 2013.
-
-
-
-
58
-
-
84874763067
-
An open-label dose escalation study to evaluate the safety of administration of nonviral stromal cell-derived factor-1 plasmid to treat symptomatic ischemic heart failure
-
Penn MS, Mendelsohn FO, Schaer GL, Sherman W, Farr M, Pastore J, Rouy D, Clemens R, Aras R, Losordo DW. An open-label dose escalation study to evaluate the safety of administration of nonviral stromal cell-derived factor-1 plasmid to treat symptomatic ischemic heart failure. Circ Res. 2013;112:816-825.
-
(2013)
Circ Res
, vol.112
, pp. 816-825
-
-
Penn, M.S.1
Mendelsohn, F.O.2
Schaer, G.L.3
Sherman, W.4
Farr, M.5
Pastore, J.6
Rouy, D.7
Clemens, R.8
Aras, R.9
Losordo, D.W.10
-
59
-
-
80052790933
-
Stromal cell-derived factor-1 retention and cardioprotection for ischemic myocardium
-
Kanki S, Segers VF, Wu W, Kakkar R, Gannon J, Sys SU, Sandrasagra A, Lee RT. Stromal cell-derived factor-1 retention and cardioprotection for ischemic myocardium. Circ Heart Fail. 2011;4:509-518.
-
(2011)
Circ Heart Fail
, vol.4
, pp. 509-518
-
-
Kanki, S.1
Segers, V.F.2
Wu, W.3
Kakkar, R.4
Gannon, J.5
Sys, S.U.6
Sandrasagra, A.7
Lee, R.T.8
-
60
-
-
84857048486
-
The bispecific SDF1-GPVI fusion protein preserves myocardial function after transient ischemia in mice
-
Ziegler M, Elvers M, Baumer Y, Leder C, Ochmann C, Schönberger T, Jürgens T, Geisler T, Schlosshauer B, Lunov O, Engelhardt S, Simmet T, Gawaz M. The bispecific SDF1-GPVI fusion protein preserves myocardial function after transient ischemia in mice. Circulation. 2012;125:685-696.
-
(2012)
Circulation
, vol.125
, pp. 685-696
-
-
Ziegler, M.1
Elvers, M.2
Baumer, Y.3
Leder, C.4
Ochmann, C.5
Schönberger, T.6
Jürgens, T.7
Geisler, T.8
Schlosshauer, B.9
Lunov, O.10
Engelhardt, S.11
Simmet, T.12
Gawaz, M.13
-
61
-
-
80052767490
-
Computational protein design to reengineer stromal cell-derived factor-1 generates an effective and translatable angiogenic polypeptide analog
-
Hiesinger W, Perez-Aguilar JM, Atluri P, Marotta NA, Frederick JR, Fitzpatrick JR 3rd, McCormick RC, Muenzer JR, Yang EC, Levit RD, Yuan LJ, Macarthur JW, Saven JG, Woo YJ. Computational protein design to reengineer stromal cell-derived factor-1? generates an effective and translatable angiogenic polypeptide analog. Circulation. 2011;124:S18-S26.
-
(2011)
Circulation
, vol.124
-
-
Hiesinger, W.1
Perez-Aguilar, J.M.2
Atluri, P.3
Marotta, N.A.4
Frederick, J.R.5
Fitzpatrick III, J.R.6
McCormick, R.C.7
Muenzer, J.R.8
Yang, E.C.9
Levit, R.D.10
Yuan, L.J.11
Macarthur, J.W.12
Saven, J.G.13
Woo, Y.J.14
-
62
-
-
0036302147
-
G-CSF induces stem cell mobilization by decreasing bone marrow SDF-1 and up-regulating CXCR4
-
Petit I, Szyper-Kravitz M, Nagler A, Lahav M, Peled A, Habler L, Ponomaryov T, Taichman RS, Arenzana-Seisdedos F, Fujii N, Sandbank J, Zipori D, Lapidot T. G-CSF induces stem cell mobilization by decreasing bone marrow SDF-1 and up-regulating CXCR4. Nat Immunol. 2002;3:687-694.
-
(2002)
Nat Immunol
, vol.3
, pp. 687-694
-
-
Petit, I.1
Szyper-Kravitz, M.2
Nagler, A.3
Lahav, M.4
Peled, A.5
Habler, L.6
Ponomaryov, T.7
Taichman, R.S.8
Arenzana-Seisdedos, F.9
Fujii, N.10
Sandbank, J.11
Zipori, D.12
Lapidot, T.13
-
63
-
-
12144286350
-
Effects of intracoronary infusion of peripheral blood stem-cells mobilised with granulocyte-colony stimulating factor on left ventricular systolic function and restenosis after coronary stenting in myocardial infarction: The MAGIC cell randomised clinical trial
-
Kang HJ, Kim HS, Zhang SY, Park KW, Cho HJ, Koo BK, Kim YJ, Soo Lee D, Sohn DW, Han KS, Oh BH, Lee MM, Park YB. Effects of intracoronary infusion of peripheral blood stem-cells mobilised with granulocyte-colony stimulating factor on left ventricular systolic function and restenosis after coronary stenting in myocardial infarction: the MAGIC cell randomised clinical trial. Lancet. 2004;363:751-756.
-
(2004)
Lancet
, vol.363
, pp. 751-756
-
-
Kang, H.J.1
Kim, H.S.2
Zhang, S.Y.3
Park, K.W.4
Cho, H.J.5
Koo, B.K.6
Kim, Y.J.7
Soo Lee, D.8
Sohn, D.W.9
Han, K.S.10
Oh, B.H.11
Lee, M.M.12
Park, Y.B.13
-
64
-
-
33644588885
-
Stem cell mobilization by granulocyte colony-stimulating factor in patients with acute myocardial infarction: A randomized controlled trial
-
Zohlnhöfer D, Ott I, Mehilli J, Schömig K, Michalk F, Ibrahim T, Meisetschläger G, von Wedel J, Bollwein H, Seyfarth M, Dirschinger J, Schmitt C, Schwaiger M, Kastrati A, Schömig A; REVIVAL-2 Investigators. Stem cell mobilization by granulocyte colony-stimulating factor in patients with acute myocardial infarction: a randomized controlled trial. JAMA. 2006;295:1003-1010.
-
(2006)
JAMA
, vol.295
, pp. 1003-1010
-
-
Zohlnhöfer, D.1
Ott, I.2
Mehilli, J.3
Schömig, K.4
Michalk, F.5
Ibrahim, T.6
Meisetschläger, G.7
Von Wedel, J.8
Bollwein, H.9
Seyfarth, M.10
Dirschinger, J.11
Schmitt, C.12
Schwaiger, M.13
Kastrati, A.14
Schömig, A.15
-
65
-
-
33646201096
-
Stem cell mobilization induced by subcutaneous granulocyte-colony stimulating factor to improve cardiac regeneration after acute ST-elevation myocardial infarction: Result of the double-blind, randomized, placebo-controlled stem cells in myocardial infarction (STEMMI) trial
-
Ripa RS, Jørgensen E, Wang Y, Thune JJ, Nilsson JC, Søndergaard L, Johnsen HE, Køber L, Grande P, Kastrup J. Stem cell mobilization induced by subcutaneous granulocyte-colony stimulating factor to improve cardiac regeneration after acute ST-elevation myocardial infarction: result of the double-blind, randomized, placebo-controlled stem cells in myocardial infarction (STEMMI) trial. Circulation. 2006;113:1983-1992.
-
(2006)
Circulation
, vol.113
, pp. 1983-1992
-
-
Ripa, R.S.1
Jørgensen, E.2
Wang, Y.3
Thune, J.J.4
Nilsson, J.C.5
Søndergaard, L.6
Johnsen, H.E.7
Køber, L.8
Grande, P.9
Kastrup, J.10
-
66
-
-
84884796588
-
-
Filgrastim for the promotion of collateral growth in patients with CAD Available at Accessed Ma 4,2013
-
Filgrastim for the promotion of collateral growth in patients with CAD. Available at: http://www.clinicaltrials.gov/ct2/show/NCT00596479.02/25/13. Accessed May 4, 2013.
-
-
-
-
67
-
-
84884806675
-
-
Peg-granulocyte-colony stimulating factor (GCSF) for coronary collateral growth in coronary artery disease patients Available at Accessed May 4,2013
-
Peg-granulocyte-colony stimulating factor (GCSF) for coronary collateral growth in coronary artery disease patients. Available at: http://www. clinicaltrials.gov/ct2/show/NCT00886509.02/25/13. Accessed May 4, 2013.
-
-
-
-
68
-
-
84884778186
-
-
Sitagliptin plus granulocyte-colony stimulating factor in acute myocardial infarction (sitagrami) Available at Accessed May 4,2013
-
Sitagliptin plus granulocyte-colony stimulating factor in acute myocardial infarction (sitagrami). Available at: http://www.clinicaltrials.gov/ ct2/show/NCT00650143.02/25/13. Accessed May 4, 2013.
-
-
-
-
69
-
-
84884777660
-
-
The effect of granulocyte colony stimulating factor (g-csf) on myocardial function after acute anterior myocardial infarction, a prospective double blind randomized placebo controlled study Available at Accessed May 4,2013
-
The effect of granulocyte colony stimulating factor (g-csf) on myocardial function after acute anterior myocardial infarction, a prospective double blind randomized placebo controlled study. Available at: http://www.clinicaltrials. gov/ct2/show/NCT00756756.02/25/13. Accessed May 4, 2013.
-
-
-
-
70
-
-
20144388775
-
G-CSF prevents cardiac remodeling after myocardial infarction by activating the Jak-Stat pathway in cardiomyocytes
-
Harada M, Qin Y, Takano H, et al. G-CSF prevents cardiac remodeling after myocardial infarction by activating the Jak-Stat pathway in cardiomyocytes. Nat Med. 2005;11:305-311.
-
(2005)
Nat Med
, vol.11
, pp. 305-311
-
-
Harada, M.1
Qin, Y.2
Takano, H.3
-
71
-
-
18844381354
-
Recombinant granulocyte colony-stimulating factor-transferrin fusion protein as an oral myelopoietic agent
-
Bai Y, Ann DK, Shen WC. Recombinant granulocyte colony-stimulating factor-transferrin fusion protein as an oral myelopoietic agent. Proc Natl Acad Sci USA. 2005;102:7292-7296.
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 7292-7296
-
-
Bai, Y.1
Ann, D.K.2
Shen, W.C.3
-
72
-
-
77649189678
-
Engineering a pharmacologically superior form of granulocyte- colonystimulating factor by fusion with gelatin-like-protein polymer
-
Huang YS, Wen XF, Wu YL, Wang YF, Fan M, Yang ZY, Liu W, Zhou LF. Engineering a pharmacologically superior form of granulocyte-colonystimulating factor by fusion with gelatin-like-protein polymer. Eur J Pharm Biopharm. 2010;74:435-441.
-
(2010)
Eur J Pharm Biopharm
, vol.74
, pp. 435-441
-
-
Huang, Y.S.1
Wen, X.F.2
Wu, Y.L.3
Wang, Y.F.4
Fan, M.5
Yang, Z.Y.6
Liu, W.7
Zhou, L.F.8
-
73
-
-
0025940020
-
Interleukins. Clinical pharmacokinetics and practical implications
-
Bocci V. Interleukins. Clinical pharmacokinetics and practical implications. Clin Pharmacokinet. 1991;21:274-284.
-
(1991)
Clin Pharmacokinet
, vol.21
, pp. 274-284
-
-
Bocci, V.1
-
74
-
-
0035908946
-
Overexpression of interleukin-1 receptor antagonist provides cardioprotection against ischemia-reperfusion injury associated with reduction in apoptosis
-
Suzuki K, Murtuza B, Smolenski RT, Sammut IA, Suzuki N, Kaneda Y, Yacoub MH. Overexpression of interleukin-1 receptor antagonist provides cardioprotection against ischemia-reperfusion injury associated with reduction in apoptosis. Circulation. 2001;104:I308-I3I3.
-
(2001)
Circulation
, vol.104
-
-
Suzuki, K.1
Murtuza, B.2
Smolenski, R.T.3
Sammut, I.A.4
Suzuki, N.5
Kaneda, Y.6
Yacoub, M.H.7
-
75
-
-
0034681920
-
Plasma concentration of interleukin-6 and the risk of future myocardial infarction among apparently healthy men
-
Ridker PM, Rifai N, Stampfer MJ, Hennekens CH. Plasma concentration of interleukin-6 and the risk of future myocardial infarction among apparently healthy men. Circulation. 2000;101:1767-1772.
-
(2000)
Circulation
, vol.101
, pp. 1767-1772
-
-
Ridker, P.M.1
Rifai, N.2
Stampfer, M.J.3
Hennekens, C.H.4
-
76
-
-
47649105757
-
Anakinra, a recombinant human interleukin-1 receptor antagonist, inhibits apoptosis in experimental acute myocardial infarction
-
Abbate A, Salloum FN, Vecile E, et al. Anakinra, a recombinant human interleukin-1 receptor antagonist, inhibits apoptosis in experimental acute myocardial infarction. Circulation. 2008;117:2670-2683.
-
(2008)
Circulation
, vol.117
, pp. 2670-2683
-
-
Abbate, A.1
Salloum, F.N.2
Vecile, E.3
-
77
-
-
77951665667
-
Interleukin-1 blockade with anakinra to prevent adverse cardiac remodeling after acute myocardial infarction (Virginia Commonwealth University Anakinra Remodeling Trial [VCU-ART] Pilot study)
-
Abbate A, Kontos MC, Grizzard JD, Biondi-Zoccai GG, Van Tassell BW, Robati R, Roach LM, Arena RA, Roberts CS, Varma A, Gelwix CC, Salloum FN, Hastillo A, Dinarello CA, Vetrovec GW; VCU-ART Investigators. Interleukin-1 blockade with anakinra to prevent adverse cardiac remodeling after acute myocardial infarction (Virginia Commonwealth University Anakinra Remodeling Trial [VCU-ART] Pilot study). Am J Cardiol. 2010;105:1371-1377.e1.
-
(2010)
Am J Cardiol
, vol.105
-
-
Abbate, A.1
Kontos, M.C.2
Grizzard, J.D.3
Biondi-Zoccai, G.G.4
Van Tassell, B.W.5
Robati, R.6
Roach, L.M.7
Arena, R.A.8
Roberts, C.S.9
Varma, A.10
Gelwix, C.C.11
Salloum, F.N.12
Hastillo, A.13
Dinarello, C.A.14
Vetrovec, G.W.15
Investigators, V.16
-
78
-
-
34247602631
-
Reversible cardiomyopathy associated with Multicentric Castleman disease: Successful treatment with tocilizumab, an anti-interleukin 6 receptor antibody
-
Kanda J, Kawabata H, Yamaji Y, Ichinohe T, Ishikawa T, Tamura T, Furukawa Y, Kimura T, Kita T, Uchiyama T. Reversible cardiomyopathy associated with Multicentric Castleman disease: successful treatment with tocilizumab, an anti-interleukin 6 receptor antibody. Int J Hematol. 2007;85:207-211.
-
(2007)
Int J Hematol
, vol.85
, pp. 207-211
-
-
Kanda, J.1
Kawabata, H.2
Yamaji, Y.3
Ichinohe, T.4
Ishikawa, T.5
Tamura, T.6
Furukawa, Y.7
Kimura, T.8
Kita, T.9
Uchiyama, T.10
-
79
-
-
84884740469
-
-
Effect of the interleukin-6 receptor antagonist tocilizumab in non-ST elevation myocardial infarction Available at Accessed May 4,2013
-
Effect of the interleukin-6 receptor antagonist tocilizumab in non-ST elevation myocardial infarction. Available at: http://www.clinicaltrials.gov/ ct2/show/NCT01491074.02/26/13. Accessed May 4, 2013.
-
-
-
-
80
-
-
0042738942
-
Erythropoietin is a potent physiologic stimulus for endothelial progenitor cell mobilization
-
Heeschen C, Aicher A, Lehmann R, Fichtlscherer S, Vasa M, Urbich C, Mildner-Rihm C, Martin H, Zeiher AM, Dimmeler S. Erythropoietin is a potent physiologic stimulus for endothelial progenitor cell mobilization. Blood. 2003;102:1340-1346.
-
(2003)
Blood
, vol.102
, pp. 1340-1346
-
-
Heeschen, C.1
Aicher, A.2
Lehmann, R.3
Fichtlscherer, S.4
Vasa, M.5
Urbich, C.6
Mildner-Rihm, C.7
Martin, H.8
Zeiher, A.M.9
Dimmeler, S.10
-
81
-
-
33845225092
-
Protective effects of erythropoietin in cardiac ischemia: From bench to bedside
-
Lipsic E, Schoemaker RG, van der Meer P, Voors AA, van Veldhuisen DJ, van Gilst WH. Protective effects of erythropoietin in cardiac ischemia: from bench to bedside. J Am Coll Cardiol. 2006;48:2161-2167.
-
(2006)
J Am Coll Cardiol
, vol.48
, pp. 2161-2167
-
-
Lipsic, E.1
Schoemaker, R.G.2
Van Der Meer, P.3
Voors, A.A.4
Van Veldhuisen, D.J.5
Van Gilst, W.H.6
-
82
-
-
0037447256
-
Recombinant human erythropoietin protects the myocardium from ischemia-reperfusion injury and promotes beneficial remodeling
-
Calvillo L, Latini R, Kajstura J, Leri A, Anversa P, Ghezzi P, Salio M, Cerami A, Brines M. Recombinant human erythropoietin protects the myocardium from ischemia-reperfusion injury and promotes beneficial remodeling. Proc Natl Acad Sci USA. 2003;100:4802-4806.
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 4802-4806
-
-
Calvillo, L.1
Latini, R.2
Kajstura, J.3
Leri, A.4
Anversa, P.5
Ghezzi, P.6
Salio, M.7
Cerami, A.8
Brines, M.9
-
83
-
-
85047691007
-
A novel protective effect of erythropoietin in the infarcted heart
-
Parsa CJ, Matsumoto A, Kim J, Riel RU, Pascal LS, Walton GB, Thompson RB, Petrofski JA, Annex BH, Stamler JS, Koch WJ. A novel protective effect of erythropoietin in the infarcted heart. J Clin Invest. 2003;112:999-1007.
-
(2003)
J Clin Invest
, vol.112
, pp. 999-1007
-
-
Parsa, C.J.1
Matsumoto, A.2
Kim, J.3
Riel, R.U.4
Pascal, L.S.5
Walton, G.B.6
Thompson, R.B.7
Petrofski, J.A.8
Annex, B.H.9
Stamler, J.S.10
Koch, W.J.11
-
84
-
-
77958518157
-
A single dose of erythropoietin in ST-elevation myocardial infarction
-
HEBE III Investigators
-
Voors AA, Belonje AM, Zijlstra F, Hillege HL, Anker SD, Slart RH, Tio RA, van ?t Hof A, Jukema JW, Peels HO, Henriques JP, Ten Berg JM, Vos J, van Gilst WH, van Veldhuisen DJ; HEBE III Investigators. A single dose of erythropoietin in ST-elevation myocardial infarction. Eur Heart J. 2010;31:2593-2600.
-
(2010)
Eur Heart J.
, vol.31
, pp. 2593-2600
-
-
Voors, A.A.1
Belonje, A.M.2
Zijlstra, F.3
Hillege, H.L.4
Anker, S.D.5
Slart, R.H.6
Tio, R.A.7
Van T Hof, A.8
Jukema, J.W.9
Peels, H.O.10
Henriques, J.P.11
Ten Berg, J.M.12
Vos, J.13
Van Gilst, W.H.14
Van Veldhuisen, D.J.15
-
85
-
-
79955877895
-
Intravenous erythropoietin in patients with ST-segment elevation myocardial infarction: REVEAL: A randomized controlled trial
-
REVEAL Investigators
-
Najjar SS, Rao SV, Melloni C, et al; REVEAL Investigators. Intravenous erythropoietin in patients with ST-segment elevation myocardial infarction: REVEAL: a randomized controlled trial. JAMA. 2011;305:1863-1872.
-
(2011)
JAMA
, vol.305
, pp. 1863-1872
-
-
Najjar, S.S.1
Rao, S.V.2
Melloni, C.3
-
86
-
-
84868001728
-
Design and rationale of low-dose erythropoietin in patients with ST-segment elevation myocardial infarction (EPO-AMI-II study): A randomized controlled clinical trial
-
Minamino T, Toba K, Higo S, Nakatani D, Hikoso S, Umegaki M, Yamamoto K, Sawa Y, Aizawa Y, Komuro I; EPO-AMI-II Study Investigators. Design and rationale of low-dose erythropoietin in patients with ST-segment elevation myocardial infarction (EPO-AMI-II study): a randomized controlled clinical trial. Cardiovasc Drugs Ther. 2012;26:409-416.
-
(2012)
Cardiovasc Drugs Ther
, vol.26
, pp. 409-416
-
-
Minamino, T.1
Toba, K.2
Higo, S.3
Nakatani, D.4
Hikoso, S.5
Umegaki, M.6
Yamamoto, K.7
Sawa, Y.8
Aizawa, Y.9
Komuro, I.10
Study Investigators, E.11
-
87
-
-
0037384789
-
Darbepoetin alfa has a longer circulating half-life and greater in vivo potency than recombinant human erythropoietin
-
Egrie JC, Dwyer E, Browne JK, Hitz A, Lykos MA. Darbepoetin alfa has a longer circulating half-life and greater in vivo potency than recombinant human erythropoietin. Exp Hematol. 2003;31:290-299.
-
(2003)
Exp Hematol
, vol.31
, pp. 290-299
-
-
Egrie, J.C.1
Dwyer, E.2
Browne, J.K.3
Hitz, A.4
Lykos, M.A.5
-
88
-
-
84872031728
-
Neuregulin in cardiovascular development and disease
-
Odiete O, Hill MF, Sawyer DB. Neuregulin in cardiovascular development and disease. Circ Res. 2012;111:1376-1385.
-
(2012)
Circ Res
, vol.111
, pp. 1376-1385
-
-
Odiete, O.1
Hill, M.F.2
Sawyer, D.B.3
-
89
-
-
0032562770
-
Neuregulins promote survival and growth of cardiac myocytes. Persistence of ErbB2 and ErbB4 expression in neonatal and adult ventricular myocytes
-
Zhao YY, Sawyer DR, Baliga RR, Opel DJ, Han X, Marchionni MA, Kelly RA. Neuregulins promote survival and growth of cardiac myocytes. Persistence of ErbB2 and ErbB4 expression in neonatal and adult ventricular myocytes. J Biol Chem. 1998;273:10261-10269.
-
(1998)
J Biol Chem
, vol.273
, pp. 10261-10269
-
-
Zhao, Y.Y.1
Sawyer, D.R.2
Baliga, R.R.3
Opel, D.J.4
Han, X.5
Marchionni, M.A.6
Kelly, R.A.7
-
90
-
-
33748929841
-
Neuregulin-1/erbB-activation improves cardiac function and survival in models of ischemic, dilated, and viral cardiomyopathy
-
Liu X, Gu X, Li Z, Li X, Li H, Chang J, Chen P, Jin J, Xi B, Chen D, Lai D, Graham RM, Zhou M. Neuregulin-1/erbB-activation improves cardiac function and survival in models of ischemic, dilated, and viral cardiomyopathy. J Am Coll Cardiol. 2006;48:1438-1447.
-
(2006)
J Am Coll Cardiol
, vol.48
, pp. 1438-1447
-
-
Liu, X.1
Gu, X.2
Li, Z.3
Li, X.4
Li, H.5
Chang, J.6
Chen, P.7
Jin, J.8
Xi, B.9
Chen, D.10
Lai, D.11
Graham, R.M.12
Zhou, M.13
-
91
-
-
77952317892
-
Phase II. Randomized, double-blind, multicenter, based on standard therapy, placebo-controlled study of the efficacy and safety of recombinant human neuregulin-1 in patients with chronic heart failure
-
Gao R, Zhang J, Cheng L, Wu X, Dong W, Yang X, Li T, Liu X, Xu Y, Li X, Zhou M. A Phase II, randomized, double-blind, multicenter, based on standard therapy, placebo-controlled study of the efficacy and safety of recombinant human neuregulin-1 in patients with chronic heart failure. J Am Coll Cardiol. 2010;55:1907-1914.
-
(2010)
J Am Coll Cardiol
, vol.55
, pp. 1907-1914
-
-
Gao, R.1
Zhang, J.2
Cheng, L.3
Wu, X.4
Dong, W.5
Yang, X.6
Li, T.7
Liu, X.8
Xu, Y.9
Li, X.10
Zhou, M.A.11
-
92
-
-
78650412123
-
Parenteral administration of recombinant human neuregulin-1 to patients with stable chronic heart failure produces favourable acute and chronic haemodynamic responses
-
Jabbour A, Hayward CS, Keogh AM, Kotlyar E, McCrohon JA, England JF, Amor R, Liu X, Li XY, Zhou MD, Graham RM, Macdonald PS. Parenteral administration of recombinant human neuregulin-1 to patients with stable chronic heart failure produces favourable acute and chronic haemodynamic responses. Eur J Heart Fail. 2011;13:83-92.
-
(2011)
Eur J Heart Fail
, vol.13
, pp. 83-92
-
-
Jabbour, A.1
Hayward, C.S.2
Keogh, A.M.3
Kotlyar, E.4
McCrohon, J.A.5
England, J.F.6
Amor, R.7
Liu, X.8
Li, X.Y.9
Zhou, M.D.10
Graham, R.M.11
Macdonald, P.S.12
-
93
-
-
84884782776
-
-
Single ascending doses of ggf2 in patients with left ventricular dysfunction and symptomatic heart failure (ggf2-1101-1) Available at Accessed May 4, 2013
-
Single ascending doses of ggf2 in patients with left ventricular dysfunction and symptomatic heart failure (ggf2-1101-1). Available at: http://www.clinicaltrials.gov/ct2/show/NCT01258387.02/26/13. Accessed May 4, 2013.
-
-
-
-
94
-
-
84874289558
-
Intravenous glial growth factor 2 (ggf2) isoform of neuregulin-1beta improves left ventricular function, gene and protein expression in rats after myocardial infarction
-
Hill MF, Patel AV, Murphy A, et al. Intravenous glial growth factor 2 (ggf2) isoform of neuregulin-1beta improves left ventricular function, gene and protein expression in rats after myocardial infarction. PLoS One. 2013;8:e55741.
-
(2013)
PLoS One
, vol.8
-
-
Hill, M.F.1
Patel, A.V.2
Murphy, A.3
-
95
-
-
79960995385
-
Engineered bivalent ligands to bias ErbB receptor-mediated signaling and phenotypes
-
Jay SM, Kurtagic E, Alvarez LM, de Picciotto S, Sanchez E, Hawkins JF, Prince RN, Guerrero Y, Treasure CL, Lee RT, Griffith LG. Engineered bivalent ligands to bias ErbB receptor-mediated signaling and phenotypes. J Biol Chem. 2011;286:27729-27740.
-
(2011)
J Biol Chem
, vol.286
, pp. 27729-27740
-
-
Jay, S.M.1
Kurtagic, E.2
Alvarez, L.M.3
De Picciotto, S.4
Sanchez, E.5
Hawkins, J.F.6
Prince, R.N.7
Guerrero, Y.8
Treasure, C.L.9
Lee, R.T.10
Griffith, L.G.11
-
96
-
-
84880113102
-
An engineered bivalent neuregulin protects against Doxorubicin-induced cardiotoxicity with reduced proneoplastic potential
-
Jay SM, Murthy AC, Hawkins JF, Wortzel JR, Steinhauser ML, Alvarez LM, Gannon J, Macrae CA, Griffith LG, Lee RT. An engineered bivalent neuregulin protects against Doxorubicin-induced cardiotoxicity with reduced proneoplastic potential. Circulation. 2013;128:152-161.
-
(2013)
Circulation
, vol.128
, pp. 152-161
-
-
Jay, S.M.1
Murthy, A.C.2
Hawkins, J.F.3
Wortzel, J.R.4
Steinhauser, M.L.5
Alvarez, L.M.6
Gannon, J.7
Macrae, C.A.8
Griffith, L.G.9
Lee, R.T.10
-
98
-
-
61649100307
-
The FGF family: Biology, pathophysiology and therapy
-
Beenken A, Mohammadi M. The FGF family: biology, pathophysiology and therapy. Nat Rev Drug Discov. 2009;8:235-253.
-
(2009)
Nat Rev Drug Discov
, vol.8
, pp. 235-253
-
-
Beenken, A.1
Mohammadi, M.2
-
99
-
-
0025850936
-
Effects of acidic fibroblast growth factor on normal and ischemic myocardium
-
Banai S, Jaklitsch MT, Casscells W, Shou M, Shrivastav S, Correa R, Epstein SE, Unger EF. Effects of acidic fibroblast growth factor on normal and ischemic myocardium. Circ Res. 1991;69:76-85.
-
(1991)
Circ Res
, vol.69
, pp. 76-85
-
-
Banai, S.1
Jaklitsch, M.T.2
Casscells, W.3
Shou, M.4
Shrivastav, S.5
Correa, R.6
Epstein, S.E.7
Unger, E.F.8
-
100
-
-
0028288687
-
Angiogenic-induced enhancement of collateral blood flow to ischemic myocardium by vascular endothelial growth factor in dogs
-
Banai S, Jaklitsch MT, Shou M, Lazarous DF, Scheinowitz M, Biro S, Epstein SE, Unger EF. Angiogenic-induced enhancement of collateral blood flow to ischemic myocardium by vascular endothelial growth factor in dogs. Circulation. 1994;89:2183-2189.
-
(1994)
Circulation
, vol.89
, pp. 2183-2189
-
-
Banai, S.1
Jaklitsch, M.T.2
Shou, M.3
Lazarous, D.F.4
Scheinowitz, M.5
Biro, S.6
Epstein, S.E.7
Unger, E.F.8
-
101
-
-
0028787355
-
Magnetic resonance mapping demonstrates benefits of VEGF-induced myocardial angiogenesis
-
Pearlman JD, Hibberd MG, Chuang ML, Harada K, Lopez JJ, Gladstone SR, Friedman M, Sellke FW, Simons M. Magnetic resonance mapping demonstrates benefits of VEGF-induced myocardial angiogenesis. Nat Med. 1995;1:1085-1089.
-
(1995)
Nat Med
, vol.1
, pp. 1085-1089
-
-
Pearlman, J.D.1
Hibberd, M.G.2
Chuang, M.L.3
Harada, K.4
Lopez, J.J.5
Gladstone, S.R.6
Friedman, M.7
Sellke, F.W.8
Simons, M.9
-
102
-
-
0037133306
-
Pharmacological treatment of coronary artery disease with recombinant fibroblast growth factor-2: Double-blind, randomized, controlled clinical trial
-
Simons M, Annex BH, Laham RJ, Kleiman N, Henry T, Dauerman H, Udelson JE, Gervino EV, Pike M, Whitehouse MJ, Moon T, Chronos NA. Pharmacological treatment of coronary artery disease with recombinant fibroblast growth factor-2: double-blind, randomized, controlled clinical trial. Circulation. 2002;105:788-793.
-
(2002)
Circulation
, vol.105
, pp. 788-793
-
-
Simons, M.1
Annex, B.H.2
Laham, R.J.3
Kleiman, N.4
Henry, T.5
Dauerman, H.6
Udelson, J.E.7
Gervino, E.V.8
Pike, M.9
Whitehouse, M.J.10
Moon, T.11
Chronos, N.A.12
-
103
-
-
0037453099
-
The VIVA trial: Vascular endothelial growth factor in Ischemia for Vascular Angiogenesis
-
Henry TD, Annex BH, McKendall GR, Azrin MA, Lopez JJ, Giordano FJ, Shah PK, Willerson JT, Benza RL, Berman DS, Gibson CM, Bajamonde A, Rundle AC, Fine J, McCluskey ER; VIVA Investigators. The VIVA trial: vascular endothelial growth factor in Ischemia for Vascular Angiogenesis. Circulation. 2003;107:1359-1365.
-
(2003)
Circulation
, vol.107
, pp. 1359-1365
-
-
Henry, T.D.1
Annex, B.H.2
McKendall, G.R.3
Azrin, M.A.4
Lopez, J.J.5
Giordano, F.J.6
Shah, P.K.7
Willerson, J.T.8
Benza, R.L.9
Berman, D.S.10
Gibson, C.M.11
Bajamonde, A.12
Rundle, A.C.13
Fine, J.14
McCluskey, E.R.15
Investigators, V.16
-
104
-
-
0026009380
-
Conversion of cysteine to serine residues alters the activity, stability, and heparin dependence of acidic fibroblast growth factor
-
Ortega S, Schaeffer MT, Soderman D, DiSalvo J, Linemeyer DL, Gimenez-Gallego G, Thomas KA. Conversion of cysteine to serine residues alters the activity, stability, and heparin dependence of acidic fibroblast growth factor. J Biol Chem. 1991;266:5842-5846.
-
(1991)
J Biol Chem
, vol.266
, pp. 5842-5846
-
-
Ortega, S.1
Schaeffer, M.T.2
Soderman, D.3
Disalvo, J.4
Linemeyer, D.L.5
Gimenez-Gallego, G.6
Thomas, K.A.7
-
105
-
-
0027317228
-
Production and characterization of an analog of acidic fibroblast growth factor with enhanced stability and biological activity
-
Arakawa T, Horan TP, Narhi LO, Rees DC, Schiffer SG, Holst PL, Prestrelski SJ, Tsai LB, Fox GM. Production and characterization of an analog of acidic fibroblast growth factor with enhanced stability and biological activity. Protein Eng. 1993;6:541-546.
-
(1993)
Protein Eng
, vol.6
, pp. 541-546
-
-
Arakawa, T.1
Horan, T.P.2
Narhi, L.O.3
Rees, D.C.4
Schiffer, S.G.5
Holst, P.L.6
Prestrelski, S.J.7
Tsai, L.B.8
Fox, G.M.9
-
106
-
-
0033982617
-
The S130K fibroblast growth factor-1 mutant induces heparin-independent proliferation and is resistant to thrombin degradation in fibrin glue
-
Shireman PK, Xue L, Maddox E, Burgess WH, Greisler HP. The S130K fibroblast growth factor-1 mutant induces heparin-independent proliferation and is resistant to thrombin degradation in fibrin glue. J Vasc Surg. 2000;31:382-390.
-
(2000)
J Vasc Surg
, vol.31
, pp. 382-390
-
-
Shireman, P.K.1
Xue, L.2
Maddox, E.3
Burgess, W.H.4
Greisler, H.P.5
-
107
-
-
0035187229
-
Structure and stability effects of mutations designed to increase the primary sequence symmetry within the core region of a beta-trefoil
-
Brych SR, Blaber SI, Logan TM, Blaber M. Structure and stability effects of mutations designed to increase the primary sequence symmetry within the core region of a beta-trefoil. Protein Sci. 2001;10:2587-2599.
-
(2001)
Protein Sci
, vol.10
, pp. 2587-2599
-
-
Brych, S.R.1
Blaber, S.I.2
Logan, T.M.3
Blaber, M.4
-
109
-
-
77956363290
-
Coupling growth-factor engineering with nanotechnology for therapeutic angiogenesis
-
Sinha Roy R, Soni S, Harfouche R, Vasudevan PR, Holmes O, de Jonge H, Rowe A, Paraskar A, Hentschel DM, Chirgadze D, Blundell TL, Gherardi E, Mashelkar RA, Sengupta S. Coupling growth-factor engineering with nanotechnology for therapeutic angiogenesis. Proc Natl Acad Sci USA. 2010;107:13608-13613.
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, pp. 13608-13613
-
-
Sinha Roy, R.1
Soni, S.2
Harfouche, R.3
Vasudevan, P.R.4
Holmes, O.5
De Jonge, H.6
Rowe, A.7
Paraskar, A.8
Hentschel, D.M.9
Chirgadze, D.10
Blundell, T.L.11
Gherardi, E.12
Mashelkar, R.A.13
Sengupta, S.14
-
110
-
-
34447092609
-
Spackling the crack: Stabilizing human fibroblast growth factor-1 by targeting the N and C terminus beta-strand interactions
-
Dubey VK, Lee J, Somasundaram T, Blaber S, Blaber M. Spackling the crack: stabilizing human fibroblast growth factor-1 by targeting the N and C terminus beta-strand interactions. J Mol Biol. 2007;371:256-268.
-
(2007)
J Mol Biol
, vol.371
, pp. 256-268
-
-
Dubey, V.K.1
Lee, J.2
Somasundaram, T.3
Blaber, S.4
Blaber, M.5
-
111
-
-
65349110432
-
Collagen-targeting vascular endothelial growth factor improves cardiac performance after myocardial infarction
-
Zhang J, Ding L, Zhao Y, Sun W, Chen B, Lin H, Wang X, Zhang L, Xu B, Dai J. Collagen-targeting vascular endothelial growth factor improves cardiac performance after myocardial infarction. Circulation. 2009;119:1776-1784.
-
(2009)
Circulation
, vol.119
, pp. 1776-1784
-
-
Zhang, J.1
Ding, L.2
Zhao, Y.3
Sun, W.4
Chen, B.5
Lin, H.6
Wang, X.7
Zhang, L.8
Xu, B.9
Dai, J.10
-
112
-
-
84884771028
-
Controlled delivery of pdgf-bb, an endothelial-derived cardiomyocyte survival factor, for myocardial protection using injectable self-assembling peptide nanofibers
-
In press
-
Hsieh PC, Davis ME, Gannon J, Macgillivray C, Lee RT. Controlled delivery of pdgf-bb, an endothelial-derived cardiomyocyte survival factor, for myocardial protection using injectable self-assembling peptide nanofibers J.Clin.Invest. 2005;In press
-
(2005)
J. Clin. Invest
-
-
Hsieh, P.C.1
Davis, M.E.2
Gannon, J.3
Macgillivray, C.4
Lee, R.T.5
-
113
-
-
31044453148
-
Controlled delivery of PDGF-BB for myocardial protection using injectable selfassembling peptide nanofibers
-
Hsieh PC, Davis ME, Gannon J, MacGillivray C, Lee RT. Controlled delivery of PDGF-BB for myocardial protection using injectable selfassembling peptide nanofibers. J Clin Invest. 2006;116:237-248.
-
(2006)
J Clin Invest
, vol.116
, pp. 237-248
-
-
Hsieh, P.C.1
Davis, M.E.2
Gannon, J.3
Macgillivray, C.4
Lee, R.T.5
-
114
-
-
33747416695
-
Local controlled intramyocardial delivery of platelet-derived growth factor improves postinfarction ventricular function without pulmonary toxicity
-
Hsieh PC, MacGillivray C, Gannon J, Cruz FU, Lee RT. Local controlled intramyocardial delivery of platelet-derived growth factor improves postinfarction ventricular function without pulmonary toxicity. Circulation. 2006;114:637-644.
-
(2006)
Circulation
, vol.114
, pp. 637-644
-
-
Hsieh, P.C.1
Macgillivray, C.2
Gannon, J.3
Cruz, F.U.4
Lee, R.T.5
-
115
-
-
34447096637
-
Local delivery of proteins and the use of self-assembling peptides
-
Segers VF, Lee RT. Local delivery of proteins and the use of self-assembling peptides. Drug Discov Today. 2007;12:561-568.
-
(2007)
Drug Discov Today
, vol.12
, pp. 561-568
-
-
Segers, V.F.1
Lee, R.T.2
-
116
-
-
34547691243
-
Periostin induces proliferation of differentiated cardiomyocytes and promotes cardiac repair
-
Kühn B, del Monte F, Hajjar RJ, Chang YS, Lebeche D, Arab S, Keating MT. Periostin induces proliferation of differentiated cardiomyocytes and promotes cardiac repair. Nat Med. 2007;13:962-969.
-
(2007)
Nat Med
, vol.13
, pp. 962-969
-
-
Kühn, B.1
Del Monte, F.2
Hajjar, R.J.3
Chang, Y.S.4
Lebeche, D.5
Arab, S.6
Keating, M.T.7
-
117
-
-
84877687210
-
Growth differentiation factor 11 is a circulating factor that reverses age-related cardiac hypertrophy
-
Loffredo FS, Steinhauser ML, Jay SM, et al. Growth differentiation factor 11 is a circulating factor that reverses age-related cardiac hypertrophy. Cell. 2013;153:828-839.
-
(2013)
Cell
, vol.153
, pp. 828-839
-
-
Loffredo, F.S.1
Steinhauser, M.L.2
Jay, S.M.3
-
118
-
-
58949084130
-
Exenatide reduces infarct size and improves cardiac function in a porcine model of ischemia and reperfusion injury
-
Timmers L, Henriques JP, de Kleijn DP, Devries JH, Kemperman H, Steendijk P, Verlaan CW, Kerver M, Piek JJ, Doevendans PA, Pasterkamp G, Hoefer IE. Exenatide reduces infarct size and improves cardiac function in a porcine model of ischemia and reperfusion injury. J Am Coll Cardiol. 2009;53:501-510.
-
(2009)
J Am Coll Cardiol
, vol.53
, pp. 501-510
-
-
Timmers, L.1
Henriques, J.P.2
De Kleijn, D.P.3
Devries, J.H.4
Kemperman, H.5
Steendijk, P.6
Verlaan, C.W.7
Kerver, M.8
Piek, J.J.9
Doevendans, P.A.10
Pasterkamp, G.11
Hoefer, I.E.12
-
119
-
-
84884785216
-
-
Myocardial protection of exenatide in ami (empire) Available at Accessed May 4, 2013
-
Myocardial protection of exenatide in ami (empire). Available at: http://www.clinicaltrials.gov/ct2/show/NCT01580514.02/26/13. Accessed May 4, 2013.
-
-
-
-
120
-
-
79960382104
-
Biased ligands for better cardiovascular drugs: Dissecting G-protein-coupled receptor pharmacology
-
DeWire SM, Violin JD. Biased ligands for better cardiovascular drugs: dissecting G-protein-coupled receptor pharmacology. Circ Res. 2011;109:205-216.
-
(2011)
Circ Res
, vol.109
, pp. 205-216
-
-
Dewire, S.M.1
Violin, J.D.2
-
121
-
-
79151470479
-
Adipocytokines, cardiovascular pathophysiology and myocardial protection
-
Smith CC, Yellon DM. Adipocytokines, cardiovascular pathophysiology and myocardial protection. Pharmacol Ther. 2011;129:206-219.
-
(2011)
Pharmacol Ther
, vol.129
, pp. 206-219
-
-
Smith, C.C.1
Yellon, D.M.2
-
122
-
-
84874430535
-
Role of adipokines in cardiovascular disease
-
Mattu HS, Randeva HS. Role of adipokines in cardiovascular disease. J Endocrinol. 2013;216:T17-T36.
-
(2013)
J Endocrinol
, vol.216
-
-
Mattu, H.S.1
Randeva, H.S.2
-
123
-
-
51749096897
-
Intravenous immunoglobulin- indications and mechanisms in cardiovascular diseases
-
Nussinovitch U, Udi N, Shoenfeld Y, Yehuda S. Intravenous immunoglobulin- indications and mechanisms in cardiovascular diseases. Autoimmun Rev. 2008;7:445-452.
-
(2008)
Autoimmun Rev
, vol.7
, pp. 445-452
-
-
Nussinovitch, U.1
Udi, N.2
Shoenfeld, Y.3
Yehuda, S.4
-
124
-
-
84884799268
-
-
Effect of intravenous immunglobulin (ivig) after myocardial infarction Available at Accessed May 4,2013
-
Effect of intravenous immunglobulin (ivig) after myocardial infarction. Available at: http://www.clinicaltrials.gov/ct2/show/NCT00430885.02/26/13. Accessed May 4, 2013.
-
-
-
-
125
-
-
71649089957
-
Experimental immunotherapeutic approaches for atherosclerosis
-
Amir S, Binder CJ. Experimental immunotherapeutic approaches for atherosclerosis. Clin Immunol. 2010;134:66-79.
-
(2010)
Clin Immunol
, vol.134
, pp. 66-79
-
-
Amir, S.1
Binder, C.J.2
-
126
-
-
84869025466
-
The PCSK9 decade
-
Lambert G, Sjouke B, Choque B, Kastelein JJ, Hovingh GK. The PCSK9 decade. J Lipid Res. 2012;53:2515-2524.
-
(2012)
J Lipid Res
, vol.53
, pp. 2515-2524
-
-
Lambert, G.1
Sjouke, B.2
Choque, B.3
Kastelein, J.J.4
Hovingh, G.K.5
-
127
-
-
33749328523
-
In vitro display technologies reveal novel biopharmaceutics
-
Rothe A, Hosse RJ, Power BE. In vitro display technologies reveal novel biopharmaceutics. FASEB J. 2006;20:1599-1610.
-
(2006)
FASEB J
, vol.20
, pp. 1599-1610
-
-
Rothe, A.1
Hosse, R.J.2
Power, B.E.3
-
129
-
-
0032535999
-
Cancer treatment by targeted drug delivery to tumor vasculature in a mouse model
-
Arap W, Pasqualini R, Ruoslahti E. Cancer treatment by targeted drug delivery to tumor vasculature in a mouse model. Science. 1998;279:377-380.
-
(1998)
Science
, vol.279
, pp. 377-380
-
-
Arap, W.1
Pasqualini, R.2
Ruoslahti, E.3
-
130
-
-
39749198122
-
Biofunctional polymer nanoparticles for intra-articular targeting and retention in cartilage
-
Rothenfluh DA, Bermudez H, O?Neil CP, Hubbell JA. Biofunctional polymer nanoparticles for intra-articular targeting and retention in cartilage. Nat Mater. 2008;7:248-254.
-
(2008)
Nat Mater
, vol.7
, pp. 248-254
-
-
Rothenfluh, D.A.1
Bermudez, H.2
Oneil, C.P.3
Hubbell, J.A.4
-
131
-
-
0034718615
-
Directed evolution of antibody fragments with monovalent femtomolar antigen-binding affinity
-
Boder ET, Midelfort KS, Wittrup KD. Directed evolution of antibody fragments with monovalent femtomolar antigen-binding affinity. Proc Natl Acad Sci USA. 2000;97:10701-10705.
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 10701-10705
-
-
Boder, E.T.1
Midelfort, K.S.2
Wittrup, K.D.3
-
132
-
-
58149336794
-
Engineered cystine-knot peptides that bind alpha(v)beta(3) integrin with antibody-like affinities
-
Silverman AP, Levin AM, Lahti JL, Cochran JR. Engineered cystine-knot peptides that bind alpha(v)beta(3) integrin with antibody-like affinities. J Mol Biol. 2009;385:1064-1075.
-
(2009)
J Mol Biol
, vol.385
, pp. 1064-1075
-
-
Silverman, A.P.1
Levin, A.M.2
Lahti, J.L.3
Cochran, J.R.4
-
133
-
-
77950344627
-
Targeted contrast-enhanced ultrasound imaging of tumor angiogenesis with contrast microbubbles conjugated to integrin-binding knottin peptides
-
Willmann JK, Kimura RH, Deshpande N, Lutz AM, Cochran JR, Gambhir SS. Targeted contrast-enhanced ultrasound imaging of tumor angiogenesis with contrast microbubbles conjugated to integrin-binding knottin peptides. J Nucl Med. 2010;51:433-440.
-
(2010)
J Nucl Med
, vol.51
, pp. 433-440
-
-
Willmann, J.K.1
Kimura, R.H.2
Deshpande, N.3
Lutz, A.M.4
Cochran, J.R.5
Gambhir, S.S.6
-
134
-
-
0030974119
-
In vitro selection and evolution of functional proteins by using ribosome display
-
Hanes J, Plückthun A. In vitro selection and evolution of functional proteins by using ribosome display. Proc Natl Acad Sci USA. 1997;94:4937-4942.
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 4937-4942
-
-
Hanes, J.1
Plückthun, A.2
-
135
-
-
0030817279
-
RNA-peptide fusions for the in vitro selection of peptides and proteins
-
Roberts RW, Szostak JW. RNA-peptide fusions for the in vitro selection of peptides and proteins. Proc Natl Acad Sci USA. 1997;94:12297-12302.
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 12297-12302
-
-
Roberts, R.W.1
Szostak, J.W.2
-
136
-
-
27144511241
-
Engineering novel binding proteins from nonimmunoglobulin domains
-
Binz HK, Amstutz P, Plückthun A. Engineering novel binding proteins from nonimmunoglobulin domains. Nat Biotechnol. 2005;23:1257-1268.
-
(2005)
Nat Biotechnol
, vol.23
, pp. 1257-1268
-
-
Binz, H.K.1
Amstutz, P.2
Plückthun, A.3
-
137
-
-
84867702136
-
Novel protein scaffolds as emerging therapeutic proteins: From discovery to clinical proof-of-concept
-
Wurch T, Pierré A, Depil S. Novel protein scaffolds as emerging therapeutic proteins: from discovery to clinical proof-of-concept. Trends Biotechnol. 2012;30:575-582.
-
(2012)
Trends Biotechnol
, vol.30
, pp. 575-582
-
-
Wurch, T.1
Pierré, A.2
Depil, S.3
-
138
-
-
79251508380
-
Phase I. and pharmacokinetic study of CT-322 (BMS-844203), a targeted Adnectin inhibitor of VEGFR-2 based on a domain of human fibronectin
-
Tolcher AW, Sweeney CJ, Papadopoulos K, Patnaik A, Chiorean EG, Mita AC, Sankhala K, Furfine E, Gokemeijer J, Iacono L, Eaton C, Silver BA, Mita M. Phase I and pharmacokinetic study of CT-322 (BMS-844203), a targeted Adnectin inhibitor of VEGFR-2 based on a domain of human fibronectin. Clin Cancer Res. 2011;17:363-371.
-
(2011)
Clin Cancer Res
, vol.17
, pp. 363-371
-
-
Tolcher, A.W.1
Sweeney, C.J.2
Papadopoulos, K.3
Patnaik, A.4
Chiorean, E.G.5
Mita, A.C.6
Sankhala, K.7
Furfine, E.8
Gokemeijer, J.9
Iacono, L.10
Eaton, C.11
Silver, B.A.12
Mita, M.13
-
139
-
-
84855604118
-
Anticalins small engineered binding proteins based on the lipocalin scaffold
-
Gebauer M, Skerra A. Anticalins small engineered binding proteins based on the lipocalin scaffold. Methods Enzymol. 2012;503:157-188.
-
(2012)
Methods Enzymol
, vol.503
, pp. 157-188
-
-
Gebauer, M.1
Skerra, A.2
-
140
-
-
0024543984
-
Functional significance of the Kunitz-type inhibitory domains of lipoprotein-associated coagulation inhibitor
-
Girard TJ, Warren LA, Novotny WF, Likert KM, Brown SG, Miletich JP, Broze GJ Jr. Functional significance of the Kunitz-type inhibitory domains of lipoprotein-associated coagulation inhibitor. Nature. 1989;338:518-520.
-
(1989)
Nature
, vol.338
, pp. 518-520
-
-
Girard, T.J.1
Warren, L.A.2
Novotny, W.F.3
Likert, K.M.4
Brown, S.G.5
Miletich, J.P.6
Broze Jr., G.J.7
-
142
-
-
28644436100
-
Multivalent avimer proteins evolved by exon shuffling of a family of human receptor domains
-
Silverman J, Liu Q, Lu Q, et al. Multivalent avimer proteins evolved by exon shuffling of a family of human receptor domains. Nat Biotechnol. 2005;23:1556-1561.
-
(2005)
Nat Biotechnol
, vol.23
, pp. 1556-1561
-
-
Silverman, J.1
Liu, Q.2
Lu, Q.3
-
143
-
-
77953172116
-
EDEMA4: A phase 3, double-blind study of subcutaneous ecallantide treatment for acute attacks of hereditary angioedema
-
Levy RJ, Lumry WR, McNeil DL, Li HH, Campion M, Horn PT, Pullman WE. EDEMA4: a phase 3, double-blind study of subcutaneous ecallantide treatment for acute attacks of hereditary angioedema. Ann Allergy Asthma Immunol. 2010;104:523-529.
-
(2010)
Ann Allergy Asthma Immunol
, vol.104
, pp. 523-529
-
-
Levy, R.J.1
Lumry, W.R.2
McNeil, D.L.3
Li, H.H.4
Campion, M.5
Horn, P.T.6
Pullman, W.E.7
-
144
-
-
33749019097
-
A chemical toolkit for proteins-an expanded genetic code
-
Xie J, Schultz PG. A chemical toolkit for proteins-an expanded genetic code. Nat Rev Mol Cell Biol. 2006;7:775-782.
-
(2006)
Nat Rev Mol Cell Biol
, vol.7
, pp. 775-782
-
-
Xie, J.1
Schultz, P.G.2
-
145
-
-
7044260692
-
Sitespecific PEGylation of proteins containing unnatural amino acids
-
Deiters A, Cropp TA, Summerer D, Mukherji M, Schultz PG. Sitespecific PEGylation of proteins containing unnatural amino acids. Bioorg Med Chem Lett. 2004;14:5743-5745.
-
(2004)
Bioorg Med Chem Lett
, vol.14
, pp. 5743-5745
-
-
Deiters, A.1
Cropp, T.A.2
Summerer, D.3
Mukherji, M.4
Schultz, P.G.5
-
146
-
-
4444291734
-
Activation of apoptosis in vivo by a hydrocarbon-stapled BH3 helix
-
Walensky LD, Kung AL, Escher I, Malia TJ, Barbuto S, Wright RD, Wagner G, Verdine GL, Korsmeyer SJ. Activation of apoptosis in vivo by a hydrocarbon-stapled BH3 helix. Science. 2004;305:1466-1470.
-
(2004)
Science
, vol.305
, pp. 1466-1470
-
-
Walensky, L.D.1
Kung, A.L.2
Escher, I.3
Malia, T.J.4
Barbuto, S.5
Wright, R.D.6
Wagner, G.7
Verdine, G.L.8
Korsmeyer, S.J.9
-
147
-
-
0032499752
-
Expressed protein ligation: A general method for protein engineering
-
Muir TW, Sondhi D, Cole PA. Expressed protein ligation: a general method for protein engineering. Proc Natl Acad Sci USA. 1998;95:6705-6710.
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 6705-6710
-
-
Muir, T.W.1
Sondhi, D.2
Cole, P.A.3
-
148
-
-
71849085755
-
A recombinant polypeptide extends the in vivo half-life of peptides and proteins in a tunable manner
-
Schellenberger V, Wang CW, Geething NC, Spink BJ, Campbell A, To W, Scholle MD, Yin Y, Yao Y, Bogin O, Cleland JL, Silverman J, Stemmer WP. A recombinant polypeptide extends the in vivo half-life of peptides and proteins in a tunable manner. Nat Biotechnol. 2009;27:1186-1190.
-
(2009)
Nat Biotechnol
, vol.27
, pp. 1186-1190
-
-
Schellenberger, V.1
Wang, C.W.2
Geething, N.C.3
Spink, B.J.4
Campbell, A.5
To, W.6
Scholle, M.D.7
Yin, Y.8
Yao, Y.9
Bogin, O.10
Cleland, J.L.11
Silverman, J.12
Stemmer, W.P.13
-
149
-
-
38849132058
-
Processing of N-terminal unnatural amino acids in recombinant human interferon-beta in Escherichia coli
-
Wang A, Winblade Nairn N, Johnson RS, Tirrell DA, Grabstein K. Processing of N-terminal unnatural amino acids in recombinant human interferon-beta in Escherichia coli. Chembiochem. 2008;9:324-330.
-
(2008)
Chembiochem
, vol.9
, pp. 324-330
-
-
Wang, A.1
Winblade Nairn, N.2
Johnson, R.S.3
Tirrell, D.A.4
Grabstein, K.5
-
150
-
-
84867550766
-
Development of copper-catalyzed azide-alkyne cycloaddition for increased in vivo efficacy of interferon ?-1b by site-specific PEGylation
-
Nairn NW, Shanebeck KD, Wang A, Graddis TJ, VanBrunt MP, Thornton KC, Grabstein K. Development of copper-catalyzed azide-alkyne cycloaddition for increased in vivo efficacy of interferon ?-1b by site-specific PEGylation. Bioconjug Chem. 2012;23:2087-2097.
-
(2012)
Bioconjug Chem
, vol.23
, pp. 2087-2097
-
-
Nairn, N.W.1
Shanebeck, K.D.2
Wang, A.3
Graddis, T.J.4
Vanbrunt, M.P.5
Thornton, K.C.6
Grabstein, K.7
-
151
-
-
84862538751
-
Synthesis of bispecific antibodies using genetically encoded unnatural amino acids
-
Kim CH, Axup JY, Dubrovska A, Kazane SA, Hutchins BA, Wold ED, Smider VV, Schultz PG. Synthesis of bispecific antibodies using genetically encoded unnatural amino acids. J Am Chem Soc. 2012;134:9918-9921.
-
(2012)
J Am Chem Soc
, vol.134
, pp. 9918-9921
-
-
Kim, C.H.1
Axup, J.Y.2
Dubrovska, A.3
Kazane, S.A.4
Hutchins, B.A.5
Wold, E.D.6
Smider, V.V.7
Schultz, P.G.8
-
152
-
-
84871928310
-
Displaying high-affinity ligands on adeno-associated viral vectors enables tumor cell-specific and safe gene transfer
-
Münch RC, Janicki H, Völker I, Rasbach A, Hallek M, Büning H, Buchholz CJ. Displaying high-affinity ligands on adeno-associated viral vectors enables tumor cell-specific and safe gene transfer. Mol Ther. 2013;21:109-118.
-
(2013)
Mol Ther
, vol.21
, pp. 109-118
-
-
Münch, R.C.1
Janicki, H.2
Völker, I.3
Rasbach, A.4
Hallek, M.5
Büning, H.6
Buchholz, C.J.7
-
153
-
-
0031759170
-
Transduction of fulllength TAT fusion proteins into mammalian cells: TAT-p27Kip1 induces cell migration
-
Nagahara H, Vocero-Akbani AM, Snyder EL, Ho A, Latham DG, Lissy NA, Becker-Hapak M, Ezhevsky SA, Dowdy SF. Transduction of fulllength TAT fusion proteins into mammalian cells: TAT-p27Kip1 induces cell migration. Nat Med. 1998;4:1449-1452.
-
(1998)
Nat Med
, vol.4
, pp. 1449-1452
-
-
Nagahara, H.1
Vocero-Akbani, A.M.2
Snyder, E.L.3
Ho, A.4
Latham, D.G.5
Lissy, N.A.6
Becker-Hapak, M.7
Ezhevsky, S.A.8
Dowdy, S.F.9
-
154
-
-
0033520487
-
In vivo protein transduction: Delivery of a biologically active protein into the mouse
-
Schwarze SR, Ho A, Vocero-Akbani A, Dowdy SF. In vivo protein transduction: delivery of a biologically active protein into the mouse. Science. 1999;285:1569-1572.
-
(1999)
Science
, vol.285
, pp. 1569-1572
-
-
Schwarze, S.R.1
Ho, A.2
Vocero-Akbani, A.3
Dowdy, S.F.4
-
155
-
-
0142149065
-
Complexes of plasmid DNA with basic domain 47-57 of the HIV-1 Tat protein are transferred to mammalian cells by endocytosis-mediated pathways
-
Ignatovich IA, Dizhe EB, Pavlotskaya AV, Akifiev BN, Burov SV, Orlov SV, Perevozchikov AP. Complexes of plasmid DNA with basic domain 47-57 of the HIV-1 Tat protein are transferred to mammalian cells by endocytosis-mediated pathways. J Biol Chem. 2003;278:42625-42636.
-
(2003)
J Biol Chem
, vol.278
, pp. 42625-42636
-
-
Ignatovich, I.A.1
Dizhe, E.B.2
Pavlotskaya, A.V.3
Akifiev, B.N.4
Burov, S.V.5
Orlov, S.V.6
Perevozchikov, A.P.7
-
156
-
-
84872588784
-
IgG-enzyme fusion protein: Pharmacokinetics and anti-drug antibody response in rhesus monkeys
-
Boado RJ, Hui EK, Lu JZ, Pardridge WM. IgG-enzyme fusion protein: pharmacokinetics and anti-drug antibody response in rhesus monkeys. Bioconjug Chem. 2013;24:97-104.
-
(2013)
Bioconjug Chem
, vol.24
, pp. 97-104
-
-
Boado, R.J.1
Hui, E.K.2
Lu, J.Z.3
Pardridge, W.M.4
-
157
-
-
33748452503
-
Molecular Trojan horses for blood-brain barrier drug delivery
-
Pardridge WM. Molecular Trojan horses for blood-brain barrier drug delivery. Curr Opin Pharmacol. 2006;6:494-500.
-
(2006)
Curr Opin Pharmacol
, vol.6
, pp. 494-500
-
-
Pardridge, W.M.1
-
158
-
-
84872150468
-
Targeted gene delivery to ischemic myocardium by homing peptide-guided polymeric carrier
-
Won YW, McGinn AN, Lee M, Bull DA, Kim SW. Targeted gene delivery to ischemic myocardium by homing peptide-guided polymeric carrier. Mol Pharm. 2013;10:378-385.
-
(2013)
Mol Pharm
, vol.10
, pp. 378-385
-
-
Won, Y.W.1
McGinn, A.N.2
Lee, M.3
Bull, D.A.4
Kim, S.W.5
-
159
-
-
44249102128
-
Aiming for the heart: Targeted delivery of drugs to diseased cardiac tissue
-
Scott RC, Crabbe D, Krynska B, Ansari R, Kiani MF. Aiming for the heart: targeted delivery of drugs to diseased cardiac tissue. Expert Opin Drug Deliv. 2008;5:459-470.
-
(2008)
Expert Opin Drug Deliv
, vol.5
, pp. 459-470
-
-
Scott, R.C.1
Crabbe, D.2
Krynska, B.3
Ansari, R.4
Kiani, M.F.5
-
160
-
-
0036462783
-
Survival and development of neonatal rat cardiomyocytes transplanted into adult myocardium
-
Müller-Ehmsen J, Whittaker P, Kloner RA, Dow JS, Sakoda T, Long TI, Laird PW, Kedes L. Survival and development of neonatal rat cardiomyocytes transplanted into adult myocardium. J Mol Cell Cardiol. 2002;34:107-116.
-
(2002)
J Mol Cell Cardiol
, vol.34
, pp. 107-116
-
-
Müller-Ehmsen, J.1
Whittaker, P.2
Kloner, R.A.3
Dow, J.S.4
Sakoda, T.5
Long, T.I.6
Laird, P.W.7
Kedes, L.8
-
161
-
-
0034971110
-
Cardiomyocyte grafting for cardiac repair: Graft cell death and anti-death strategies
-
Zhang M, Methot D, Poppa V, Fujio Y, Walsh K, Murry CE. Cardiomyocyte grafting for cardiac repair: graft cell death and anti-death strategies. J Mol Cell Cardiol. 2001;33:907-921.
-
(2001)
J Mol Cell Cardiol
, vol.33
, pp. 907-921
-
-
Zhang, M.1
Methot, D.2
Poppa, V.3
Fujio, Y.4
Walsh, K.5
Murry, C.E.6
-
162
-
-
0035353166
-
Pharmacologically regulated cell therapy
-
Neff T, Blau CA. Pharmacologically regulated cell therapy. Blood. 2001;97:2535-2540.
-
(2001)
Blood
, vol.97
, pp. 2535-2540
-
-
Neff, T.1
Blau, C.A.2
-
163
-
-
84870202567
-
Cardiac regenerative capacity and mechanisms
-
Kikuchi K, Poss KD. Cardiac regenerative capacity and mechanisms. Annu Rev Cell Dev Biol. 2012;28:719-741.
-
(2012)
Annu Rev Cell Dev Biol
, vol.28
, pp. 719-741
-
-
Kikuchi, K.1
Poss, K.D.2
-
165
-
-
84860461058
-
Heart repair: From natural mechanisms of cardiomyocyte production to the design of new cardiac therapies
-
Martin-Puig S, Fuster V, Torres M. Heart repair: from natural mechanisms of cardiomyocyte production to the design of new cardiac therapies. Ann N Y Acad Sci. 2012;1254:71-81.
-
(2012)
Ann N y Acad Sci
, vol.1254
, pp. 71-81
-
-
Martin-Puig, S.1
Fuster, V.2
Torres, M.3
|