Engineered bivalent ligands to bias ErbB receptor-mediated signaling and phenotypes

Journal of Biological Chemistry

Volumn 286, Issue 31, 2011, Pages 27729-27740

  Jay, Steven M ^a,c,d   Kurtagic, Elma ^a   Alvarez, Luis M ^a   De Picciotto, Seymour ^a   Sanchez, Edgar ^a   Hawkins, Jessica F ^d   Prince, Robin N ^a,d   Guerrero, Yadir ^a   Treasure, Carolyn L ^d   Lee, Richard T ^c,d   Griffith, Linda G ^b,c,d  

^a Department of Biological Engineering ^*  (United States)

^b Massachusetts Institute of Technology Cambridge   (United States)

^c HARVARD STEM CELL INSTITUTE   (United States)

^d BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIVALENT LIGANDS; CANCER CELLS; EPIDERMAL GROWTH FACTORS; HETERODIMERS; KINASE INHIBITORS; LIGAND AFFINITY; RECEPTOR INTERACTION; RECEPTOR-MEDIATED SIGNALING; THERAPEUTIC POTENTIALS;

CELL DEATH; CHEMOTHERAPY; DISEASES; SIGNALING;

LIGANDS;

EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR 2; HER3 PROTEIN; HETERODIMER; NEU DIFFERENTIATION FACTOR; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CANCER CELL; CELL PROLIFERATION; CELL STRAIN MCF 7; CONTROLLED STUDY; DIMERIZATION; GROWTH INHIBITION; HUMAN; HUMAN CELL; LIGAND BINDING; MESENCHYMAL STEM CELL; MIGRATION INHIBITION; OLIGOMERIZATION; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

APOPTOSIS; CARCINOMA, NON-SMALL-CELL LUNG; CELL LINE, TUMOR; CELL PROLIFERATION; HUMANS; LIGANDS; LUNG NEOPLASMS; NEUREGULIN-1; PHENOTYPE; PROTEIN ENGINEERING; RECEPTOR, ERBB-3; SIGNAL TRANSDUCTION; SURFACE PLASMON RESONANCE;

EID: 79960995385     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.221093     Document Type: Article

References (67)

1. Olayioye, M. A., Neve, R. M., Lane, H. A., and Hynes, N. E. (2000) EMBO. J. 19, 3159-3167
2. Burgess, A. W., Cho, H. S., Eigenbrot, C., Ferguson, K. M., Garrett, T. P., Leahy, D. J., Lemmon, M. A., Sliwkowski, M. X., Ward, C. W., and Yokoyama, S. (2003) Mol. Cell 12, 541-552
3. Ciardiello, F., and Tortora, G. (2008) N. Engl. J. Med. 358, 1160-1174
4. De, P., and Leyland-Jones, B. (2010) J. Clin. Oncol. 28, 1091-1096
5. Schoeberl, B., Faber, A. C., Li, D., Liang, M. C., Crosby, K., Onsum, M., Burenkova, O., Pace, E., Walton, Z., Nie, L., Fulgham, A., Song, Y., Nielsen, U. B., Engelman, J. A., and Wong, K. K. (2010) Cancer Res. 70, 2485-2494
6. Cardó-Vila, M., Giordano, R. J., Sidman, R. L., Bronk, L. F., Fan, Z., Mendelsohn, J., Arap, W., and Pasqualini, R. (2010) Proc. Natl. Acad. Sci. U.S.A. 107, 5118-5123
7. Junttila, T. T., Akita, R. W., Parsons, K., Fields, C., Lewis Phillips, G. D., Friedman, L. S., Sampath, D., and Sliwkowski, M. X. (2009) Cancer Cell 15, 429-440
8. Lindzen, M., Lavi, S., Leitner, O., and Yarden, Y. (2010) Proc. Natl. Acad. Sci. U.S.A. 107, 12559-12563
9. Lemmon, M. A. (2009) Exp. Cell Res. 315, 638-648
10. Linggi, B., and Carpenter, G. (2006) Trends Cell Biol. 16, 649-656
11. Riese, D. J., 2nd, van Raaij, T. M., Plowman, G. D., Andrews, G. C., and Stern, D. F. (1995) Mol. Cell. Biol. 15, 5770-5776
12. Schneider, M. R., and Wolf, E. (2009) J. Cell. Physiol. 218, 460-466
13. Kochupurakkal, B. S., Harari, D., Di-Segni, A., Maik-Rachline, G., Lyass, L., Gur, G., Kerber, G., Citri, A., Lavi, S., Eilam, R., Chalifa-Caspi, V., Eshhar, Z., Pikarsky, E., Pinkas-Kramarski, R., Bacus, S. S., and Yarden, Y. (2005) J. Biol. Chem. 280, 8503-8512
14. Baselga, J., and Swain, S. M. (2009) Nat. Rev. Cancer 9, 463-475
15. Shi, F., Telesco, S. E., Liu, Y., Radhakrishnan, R., and Lemmon, M. A. (2010) Proc. Natl. Acad. Sci. U.S.A. 107, 7692-7697
16. Campbell, M. R., Amin, D., and Moasser, M. M. (2010) Clin. Cancer Res. 16, 1373-1383
17. Kruser, T. J., and Wheeler, D. L. (2010) Exp. Cell Res. 316, 1083-1100
18. Amin, D. N., Sergina, N., Ahuja, D., McMahon, M., Blair, J. A., Wang, D., Hann, B., Koch, K. M., Shokat, K. M., and Moasser, M. M. (2010) Sci. Transl. Med. 2, 16ra17
19. Turke, A. B., Zejnullahu, K., Wu, Y. L., Song, Y., Dias-Santagata, D., Lifshits, E., Toschi, L., Rogers, A., Mok, T., Sequist, L., Lindeman, N. I., Murphy, C., Akhavanfard, S., Yeap, B. Y., Xiao, Y., Capelletti, M., Iafrate, A. J., Lee, C., Christensen, J. G., Engelman, J. A., and Jänne, P. A. (2010) Cancer Cell 17, 77-88
20. Ware, C. F., VanArsdale, S., and VanArsdale, T. L. (1996) J. Cell. Biochem. 60, 47-55
21. Barbacci, E. G., Guarino, B. C., Stroh, J. G., Singleton, D. H., Rosnack, K. J., Moyer, J. D., and Andrews, G. C. (1995) J. Biol. Chem. 270, 9585-9589
22. Moll, J. R., Ruvinov, S. B., Pastan, I., and Vinson, C. (2001) Protein. Sci. 10, 649-655
23. Xue, C., Liang, F., Mahmood, R., Vuolo, M., Wyckoff, J., Qian, H., Tsai, K. L., Kim, M., Locker, J., Zhang, Z. Y., and Segall, J. E. (2006) Cancer Res. 66, 1418-1426
24. Martin, A., Baker, T. A., and Sauer, R. T. (2005) Nature 437, 1115-1120
25. Cho, H. S., and Leahy, D. J. (2002) Science 297, 1330-1333
26. Warren, C. M., Kani, K., and Landgraf, R. (2006) J. Biol. Chem. 281, 27306-27316
27. Iyer, A. K., Tran, K. T., Borysenko, C. W., Cascio, M., Camacho, C. J., Blair, H. C., Bahar, I., and Wells, A. (2007) J. Cell. Physiol. 211, 748-758
28. Ogiso, H., Ishitani, R., Nureki, O., Fukai, S., Yamanaka, M., Kim, J. H., Saito, K., Sakamoto, A., Inoue, M., Shirouzu, M., and Yokoyama, S. (2002) Cell 110, 775-787
29. Franklin, M. C., Carey, K. D., Vajdos, F. F., Leahy, D. J., de Vos, A. M., and Sliwkowski, M. X. (2004) Cancer Cell 5, 317-328
30. Liu, H., Buus, R., Clague, M. J., and Urbé, S. (2009) PLoS One 4, e5544
31. Wallasch, C., Weiss, F. U., Niederfellner, G., Jallal, B., Issing, W., and Ullrich, A. (1995) EMBO J. 14, 4267-4275
32. Aguilar, Z., Akita, R. W., Finn, R. S., Ramos, B. L., Pegram, M. D., Kabbinavar, F. F., Pietras, R. J., Pisacane, P., Sliwkowski, M. X., and Slamon, D. J. (1999) Oncogene 18, 6050-6062
33. van der Woning, S. P., and van Zoelen, E. J. (2009) Biochem. Biophys. Res. Commun. 378, 285-289
34. Hutcheson, I. R., Goddard, L., Barrow, D., McClelland, R. A., Francies, H. E., Knowlden, J. M., Nicholson, R. I., and Gee, J. M. (2011) Breast Cancer Res. 13, R29
35. Kani, K., Warren, C. M., Kaddis, C. S., Loo, J. A., and Landgraf, R. (2005) J. Biol. Chem. 280, 8238-8247
36. Pinkas-Kramarski, R., Lenferink, A. E., Bacus, S. S., Lyass, L., van de Poll, M. L., Klapper, L. N., Tzahar, E., Sela, M., van Zoelen, E. J., and Yarden, Y. (1998) Oncogene 16, 1249-1258
37. Jura, N., Shan, Y., Cao, X., Shaw, D. E., and Kuriyan, J. (2009) Proc. Natl. Acad. Sci. U.S.A. 106, 21608-21613
38. Park, E., Baron, R., and Landgraf, R. (2008) Biochemistry 47, 11992-12005
39. Berger, M. B., Mendrola, J. M., and Lemmon, M. A. (2004) FEBS Lett. 569, 332-336
40. Bublil, E. M., Pines, G., Patel, G., Fruhwirth, G., Ng, T., and Yarden, Y. (2010) FASEB J. 24, 4744-4755
41. Engelman, J. A., Jänne, P. A., Mermel, C., Pearlberg, J., Mukohara, T., Fleet, C., Cichowski, K., Johnson, B. E., and Cantley, L. C. (2005) Proc. Natl. Acad. Sci. U.S.A. 102, 3788-3793
42. Chung, I., Akita, R., Vandlen, R., Toomre, D., Schlessinger, J., and Mellman, I. (2010) Nature 464, 783-787
43. Hutchings, S. E., and Sato, G. H. (1978) Proc. Natl. Acad. Sci. U.S.A. 75, 901-904
44. Oksvold, M. P., Skarpen, E., Lindeman, B., Roos, N., and Huitfeldt, H. S. (2000) J. Histochem. Cytochem. 48, 21-33
45. Berkers, J. A., van Bergen en Henegouwen, P. M., and Boonstra, J. (1991) J. Biol. Chem. 266, 922-927
46. Vieira, A. V., Lamaze, C., and Schmid, S. L. (1996) Science 274, 2086-2089
47. Tamama, K., Fan, V. H., Griffith, L. G., Blair, H. C., and Wells, A. (2006) Stem Cells 24, 686-695
48. Chuu, C. P., Chen, R. Y., Barkinge, J. L., Ciaccio, M. F., and Jones, R. B. (2008) Mol. Cancer Res. 6, 885-891
49. Soler, M., Mancini, F., Meca-Cortés, O., Sánchez-Cid, L., Rubio, N., López-Fernández, S., Lozano, J. J., Blanco, J., Fernández, P. L., and Thomson, T. M. (2009) Int. J. Cancer 125, 2565-2575
50. Sithanandam, G., Fornwald, L. W., Fields, J., and Anderson, L. M. (2005) Oncogene 24, 1847-1859
51. Kumar, N., Afeyan, R., Kim, H. D., and Lauffenburger, D. A. (2008) Mol. Pharmacol. 73, 1668-1678
52. Vadlamudi, R., Adam, L., Tseng, B., Costa, L., and Kumar, R. (1999) Cancer Res. 59, 2843-2846
53. Yang, C., Liu, Y., Lemmon, M. A., and Kazanietz, M. G. (2006) Mol. Cell. Biol. 26, 831-842
54. Xia, W., Liu, L. H., Ho, P., and Spector, N. L. (2004) Oncogene 23, 646-653
55. Yamada, T., Matsumoto, K., Wang, W., Li, Q., Nishioka, Y., Sekido, Y., Sone, S., and Yano, S. (2010) Clin. Cancer Res. 16, 174-183
56. Starr, A., Greif, J., Vexler, A., Ashkenazy-Voghera, M., Gladesh, V., Rubin, C., Kerber, G., Marmor, S., Lev-Ari, S., Inbar, M., Yarden, Y., and Ben- Yosef, R. (2006) Int. J. Cancer 119, 269-274
57. Crovello, C. S., Lai, C., Cantley, L. C., and Carraway, K. L., 3rd. (1998) J. Biol. Chem. 273, 26954-26961
58. Imai, K., and Takaoka, A. (2006) Nat. Rev. Cancer 6, 714-727
59. Muthuswamy, S. K., Gilman, M., and Brugge, J. S. (1999) Mol. Cell. Biol. 19, 6845-6857
60. Nakaji-Hirabayashi, T., Kato, K., and Iwata, H. (2009) Bioconjug. Chem. 20, 102-110
61. Tao, R. H., and Maruyama, I. N. (2008) J. Cell Sci. 121, 3207-3217
62. Yang, S., Raymond-Stintz, M. A., Ying, W., Zhang, J., Lidke, D. S., Steinberg, S. L., Williams, L., Oliver, J. M., and Wilson, B. S. (2007) J. Cell Sci. 120, 2763-2773
63. Wang, W., Li, Q., Yamada, T., Matsumoto, K., Matsumoto, I., Oda, M., Watanabe, G., Kayano, Y., Nishioka, Y., Sone, S., and Yano, S. (2009) Clin. Cancer Res. 15, 6630-6638
64. Sheng, Q., Liu, X., Fleming, E., Yuan, K., Piao, H., Chen, J., Moustafa, Z., Thomas, R. K., Greulich, H., Schinzel, A., Zaghlul, S., Batt, D., Ettenberg, S., Meyerson, M., Schoeberl, B., Kung, A. L., Hahn, W. C., Drapkin, R., Livingston, D. M., and Liu, J. F. (2010) Cancer Cell 17, 298-310
65. Lane, H. A., Beuvink, I., Motoyama, A. B., Daly, J. M., Neve, R. M., and Hynes, N. E. (2000) Mol. Cell. Biol. 20, 3210-3223
66. Muthuswamy, S. K., Li, D., Lelievre, S., Bissell, M. J., and Brugge, J. S. (2001) Nat. Cell Biol. 3, 785-792
67. Wiley, H. S., Shvartsman, S. Y., and Lauffenburger, D. A. (2003) Trends Cell Biol. 13, 43-50