Heart repair: From natural mechanisms of cardiomyocyte production to the design of new cardiac therapies

Annals of the New York Academy of Sciences

Volumn 1254, Issue 1, 2012, Pages 71-81

  Martin Puig, Silvia ^a   Fuster, Valentín ^a,b   Torres, Miguel ^a  

^a CENTRO NACIONAL DE INVESTIGACIONES CARDIOVASCULARES CNIC   (Spain)

^b MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

Cardiac regenerative therapies; Cardiomyocyte generation; Heart development; Heart homeostasis; Heart injury

Indexed keywords

MICRORNA; MITOGEN ACTIVATED PROTEIN KINASE P38; NEU DIFFERENTIATION FACTOR; TRANSCRIPTION FACTOR RUNX2;

ARTICLE; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL SURVIVAL; EPITHELIAL MESENCHYMAL TRANSITION; HEART DEVELOPMENT; HEART LEFT VENTRICLE; HEART MUSCLE; HEART MUSCLE CELL; HEART OUTFLOW TRACT OBSTRUCTION; HEART REGENERATION; HEART REPAIR; HEART RIGHT VENTRICLE; HEART RIGHT VENTRICLE OUTFLOW TRACT; HOMEOSTASIS; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; STEM CELL; TISSUE REGENERATION;

AMPHIBIA; DANIO RERIO; MAMMALIA; TELEOSTEI; VERTEBRATA;

EID: 84860461058     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2012.06488.x     Document Type: Article

References (68)

1. Bergmann, O. et al 2009. Evidence for cardiomyocyte renewal in humans. Science 324: 98-102.
2. Hsieh, P.C. et al 2007. Evidence from a genetic fate-mapping study that stem cells refresh adult mammalian cardiomyocytes after injury. Nat. Med. 13: 970-974.
3. Loffredo, F.S. et al. 2011. Bone marrow-derived cell therapy stimulates endogenous cardiomyocyte progenitors and promotes cardiac repair. Cell Stem Cell 8: 389-398.
4. Smart, N. et al 2011. De novo cardiomyocytes from within the activated adult heart after injury. Nature 474: 640-644.
5. Laflamme, M.A. & C.E. Murry 2011. Heart regeneration. Nature 473: 326-335.
6. Chong, J.J. et al 2011. Adult cardiac-resident MSC-like stem cells with a proepicardial origin. Cell Stem Cell 9: 527-540.
7. Leri, A., J. Kajstura & P. Anversa 2011. Role of cardiac stem cells in cardiac pathophysiology: a paradigm shift in human myocardial biology. Circ. Res. 109: 941-961.
8. Nakajima, Y. 2010. Second lineage of heart forming region provides new understanding of conotruncal heart defects. Congenit. Anom. (Kyoto) 50: 8-14.
9. Buckingham, M., S. Meilhac & S. Zaffran 2005. Building the mammalian heart from two sources of myocardial cells. Nat. Rev. Genet. 6: 826-835.
10. Aanhaanen, W.T. et al 2012. Developmental origin, growth, and three-dimensional architecture of the atrioventricular conduction axis of the mouse heart. Circ. Res. 107: 728-736.
11. Moorman, A.F., G. van den Berg, R.H. Anderson, V.M. Christoffels 2010. Early cardiac growth and the ballooning model of cardiac chamber formation. In Heart Development and Regeneration, Vol. 1. N. Rosenthal & R.P. Harvey, Eds.: 219-233. Elsevier. New York
12. Cai, C.L. et al 2003. Isl1 identifies a cardiac progenitor population that proliferates prior to differentiation and contributes a majority of cells to the heart. Dev. Cell 5: 877-889.
13. Mjaatvedt, C.H. et al 2001. The outflow tract of the heart is recruited from a novel heart-forming field. Dev. Biol. 238: 97-109.
14. Waldo, K.L. et al 2001. Conotruncal myocardium arises from a secondary heart field. Development 128: 3179-3188.
15. Kelly, R.G., N.A. Brown & M.E. Buckingham 2001. The arterial pole of the mouse heart forms from Fgf10-expressing cells in pharyngeal mesoderm. Dev. Cell 1: 435-440.
16. Zaffran, S. et al 2004. Right ventricular myocardium derives from the anterior heart field. Circ. Res. 95: 261-268.
17. Meilhac, S.M. et al 2004. The clonal origin of myocardial cells in different regions of the embryonic mouse heart. Dev. Cell 6: 685-698.
18. + progenitor cells lead to cardiac, smooth muscle, and endothelial cell diversification. Cell 127: 1151-1165.
19. Sun, Y. et al 2007. Islet 1 is expressed in distinct cardiovascular lineages, including pacemaker and coronary vascular cells. Dev. Biol. 304: 286-296.
20. Milgrom-Hoffman, M. et al 2011. The heart endocardium is derived from vascular endothelial progenitors. Development 138: 4777-4787.
21. Snider, P. et al 2007. Cardiovascular development and the colonizing cardiac neural crest lineage. ScientificWorldJournal 7: 1090-1113.
22. Perez-Pomares, J.M. & J.L. de la Pompa 2011. Signaling during epicardium and coronary vessel development. Circ. Res. 109: 1429-1442.
23. Cai, C.L. et al 2008. A myocardial lineage derives from Tbx18 epicardial cells. Nature 454: 104-108.
24. Zhou, B. et al 2008. Epicardial progenitors contribute to the cardiomyocyte lineage in the developing heart. Nature 454: 109-113.
25. van den Berg, G. & A.F. Moorman 2009. Concepts of cardiac development in retrospect. Pediatr. Cardiol. 30: 580-587.
26. Soufan, A.T. et al 2006. Regionalized sequence of myocardial cell growth and proliferation characterizes early chamber formation. Circ. Res. 99: 545-552.
27. Sizarov, A. et al 2011. Formation of the building plan of the human heart: morphogenesis, growth, and differentiation. Circulation 123: 1125-1135.
28. de Boer, B.A. et al 2011. The interactive presentation of 3D information obtained from reconstructed datasets and 3D placement of single histological sections with the 3D portable document format. Development 138: 159-167.
29. Leu, M., E. Ehler & J.C. Perriard 2001. Characterisation of postnatal growth of the murine heart. Anat. Embryol. (Berl). 204: 217-224.
30. Porrello, E.R., R.E. Widdop & L.M. Delbridge 2008. Early origins of cardiac hypertrophy: does cardiomyocyte attrition programme for pathological 'catch-up' growth of the heart? Clin. Exp. Pharmacol. Physiol. 35: 1358-1364.
31. Risebro CA, R. P. 2006. Formation of the ventricles. Scientific World Journal 6: 1862-1880.
32. Wills, A.A. et al 2008. Regulated addition of new myocardial and epicardial cells fosters homeostatic cardiac growth and maintenance in adult zebrafish. Development 135: 183-192.
33. Poss, K.D., L.G. Wilson & M.T. Keating 2002. Heart regeneration in zebrafish. Science 298: 2188-2190.
34. Porrello, E.R. et al 2011. Transient regenerative potential of the neonatal mouse heart. Science 331: 1078-1080.
35. + epicardial cells adopt non-myocardial fates during zebrafish heart development and regeneration. Development. 138: 2895-2902.
36. Kikuchi, K. et al 2011. Retinoic acid production by endocardium and epicardium is an injury response essential for zebrafish heart regeneration. Dev. Cell 20: 397-404.
37. Lepilina, A. et al 2006. A dynamic epicardial injury response supports progenitor cell activity during zebrafish heart regeneration. Cell 127: 607-619.
38. Gonzalez-Rosa, J.M. et al 2011. Extensive scar formation and regression during heart regeneration after cryoinjury in zebrafish. Development 138: 1663-1674.
39. Jopling, C. et al 2010. Zebrafish heart regeneration occurs by cardiomyocyte dedifferentiation and proliferation. Nature 464: 606-609.
40. Kikuchi, K. et al 2010. Primary contribution to zebrafish heart regeneration by gata4(+) cardiomyocytes. Nature 464: 601-605.
41. Zhou, B. et al 2011. Adult mouse epicardium modulates myocardial injury by secreting paracrine factors. J. Clin. Invest. 121: 1894-1904.
42. Zhou, B. et al 2012. Thymosin beta 4 treatment after myocardial infarction does not reprogram epicardial cells into cardiomyocytes. J. Mol. Cell Cardiol. 52: 43-47.
43. Beltrami, A.P. et al 2001. Evidence that human cardiac myocytes divide after myocardial infarction. N. Engl. J. Med. 344: 1750-1757.
44. Drenckhahn, J.D. et al 2008. Compensatory growth of healthy cardiac cells in the presence of diseased cells restores tissue homeostasis during heart development. Dev. Cell 15: 521-533.
45. Li, F. et al 1996. Rapid transition of cardiac myocytes from hyperplasia to hypertrophy during postnatal development. J. Mol. Cell Cardiol. 28: 1737-1746.
46. Olivetti, G. et al 1996. Acute myocardial infarction in humans is associated with activation of programmed myocyte cell death in the surviving portion of the heart. J. Mol. Cell Cardiol. 28: 2005-2016.
47. Mercola, M., P. Ruiz-Lozano & M.D. Schneider 2011. Cardiac muscle regeneration: lessons from development. Genes Dev. 25: 299-309.
48. Mummery, C. & M.J. Goumans 2011. Shedding new light on the mechanism underlying stem cell therapy for the heart. Mol. Ther. 19: 1186-1188.
49. Martin-Puig, S., Z. Wang & K.R. Chien 2008. Lives of a heart cell: tracing the origins of cardiac progenitors. Cell Stem Cell 2: 320-331.
50. Bolli, R. et al 2011. Cardiac stem cells in patients with ischaemic cardiomyopathy (SCIPIO): initial results of a randomised phase 1 trial. Lancet 378: 1847-1857.
51. Pasumarthi, K.B. & L.J. Field 2002. Cardiomyocyte cell cycle regulation. Circ. Res. 90: 1044-1054.
52. Engel, F.B. et al 2006. FGF1/p38 MAP kinase inhibitor therapy induces cardiomyocyte mitosis, reduces scarring, and rescues function after myocardial infarction. Proc. Natl. Acad. Sci. USA. 103: 15546-15551.
53. Kuhn, B. et al 2007. Periostin induces proliferation of differentiated cardiomyocytes and promotes cardiac repair. Nat. Med. 13: 962-969.
54. Bersell, K. et al 2009. Neuregulin1/ErbB4 signaling induces cardiomyocyte proliferation and repair of heart injury. Cell 138: 257-270.
55. van Rooij, E., W.S. Marshall & E.N. Olson 2008. Toward microRNA-based therapeutics for heart disease: the sense in antisense. Circ. Res. 103: 919-928.
56. Hassink, R.J. et al 2008. Cardiomyocyte cell cycle activation improves cardiac function after myocardial infarction. Cardiovasc. Res. 78: 18-25.
57. Rasmussen, T.L. et al 2011. Getting to the heart of myocardial stem cells and cell therapy. Circulation 123: 1771-1779.
58. Williams, A.R. & J.M. Hare 2011. Mesenchymal stem cells: biology, pathophysiology, translational findings, and therapeutic implications for cardiac disease. Circ. Res. 109: 923-940.
59. Zaruba, M.M. et al 2009. Synergy between CD26/DPP-IV inhibition and G-CSF improves cardiac function after acute myocardial infarction. Cell Stem Cell 4: 313-323.
60. Davis, R.P. et al 2011. Pluripotent stem cell models of cardiac disease and their implication for drug discovery and development. Trends Mol. Med. 17: 475-484.
61. Zhao, T. et al 2011. Immunogenicity of induced pluripotent stem cells. Nature 474: 212-215.
62. Okita, K., N. Nagata & S. Yamanaka 2011. Immunogenicity of induced pluripotent stem cells. Circ. Res. 109: 720-721.
63. Elliott, D.A. et al 2011. NKX2-5(eGFP/w) hESCs for isolation of human cardiac progenitors and cardiomyocytes. Nat. Methods 8: 1037-1040.
64. Dubois, N.C. et al 2011. SIRPA is a specific cell-surface marker for isolating cardiomyocytes derived from human pluripotent stem cells. Nat. Biotechnol. 29: 1011-1018.
65. Ieda, M. et al 2010. Direct reprogramming of fibroblasts into functional cardiomyocytes by defined factors. Cell 142: 375-386.
66. Efe, J.A. et al 2011. Conversion of mouse fibroblasts into cardiomyocytes using a direct reprogramming strategy. Nat. Cell Biol. 13: 215-222.
67. +-ATPase in patients with advanced heart failure. Circulation 124: 304-313.
68. Kho, C. et al 2011. SUMO1-dependent modulation of SERCA2a in heart failure. Nature 477: 601-605.