Targeted contrast-enhanced ultrasound imaging of tumor angiogenesis with contrast microbubbles conjugated to integrin-binding knottin peptides

Journal of Nuclear Medicine

Volumn 51, Issue 3, 2010, Pages 433-440

  Willmann, Jürgen K ^a   Kimura, Richard H ^a   Deshpande, Nirupama ^a   Lutz, Amelie M ^a   Cochran, Jennifer R ^a   Gambhir, Sanjiv S ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Contrast enhanced ultrasound imaging; Knottin peptides; Ovarian cancer; Targeted ultrasound imaging

Indexed keywords

DISULFIDE CONSTRAINED CYSTINE KNOT PEPTIDE; ECHO CONTRAST MEDIUM; FLUOROCARBON; PEPTIDE; PEPTIDOMIMETIC AGENT; UNCLASSIFIED DRUG; VITRONECTIN RECEPTOR; ARGINYL-GLYCYL-ASPARTIC ACID; ARGINYLGLYCYLASPARTIC ACID; BIOMIMETIC MATERIAL; CONTRAST MEDIUM; DIAGNOSTIC AGENT; INTEGRIN; MONOCLONAL ANTIBODY; OLIGOPEPTIDE;

ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTRAST ENHANCEMENT; CONTROLLED STUDY; ENDOTHELIUM CELL; FEMALE; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; MICROBUBBLE; MOUSE; NONHUMAN; OVARY ADENOCARCINOMA; PRIORITY JOURNAL; TUMOR XENOGRAFT; ULTRASOUND; AMINO ACID SEQUENCE; ANIMAL; CELL ADHESION; CELL TRANSFORMATION; CHEMISTRY; DRUG DESIGN; ECHOGRAPHY; FLUORESCENT ANTIBODY TECHNIQUE; GENE EXPRESSION REGULATION; GENETICS; IMMUNOLOGY; METABOLISM; MOLECULAR GENETICS; NEOPLASM; NEOVASCULARIZATION (PATHOLOGY); PATHOLOGY; REPRODUCIBILITY; SYNTHESIS; TUMOR CELL LINE; VASCULARIZATION;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES, MONOCLONAL; BIOMIMETIC MATERIALS; CELL ADHESION; CELL LINE, TUMOR; CELL TRANSFORMATION, NEOPLASTIC; CONTRAST MEDIA; DRUG DESIGN; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; INTEGRIN ALPHAVBETA3; INTEGRINS; MICE; MICROBUBBLES; MOLECULAR SEQUENCE DATA; NEOPLASMS; NEOVASCULARIZATION, PATHOLOGIC; OLIGOPEPTIDES; REPRODUCIBILITY OF RESULTS;

EID: 77950344627     PISSN: 01615505     EISSN: None     Source Type: Journal    
DOI: 10.2967/jnumed.109.068007     Document Type: Article

References (27)

1. Willmann JK, van Bruggen N, Dinkelborg LM, Gambhir SS. Molecular imaging in drug development. Nat Rev Drug Discov. 2008;7:591-607.
2. Lindner JR. Microbubbles in medical imaging: current applications and future directions. Nat Rev Drug Discov. 2004;3:527-532. (Pubitemid 38807535)
3. Folkman J. Angiogenesis. Annu Rev Med. 2006;57:1-18.
4. Hanahan D, Weinberg RA. The hallmarks of cancer. Cell. 2000;100:57-70.
5. Hood JD, Cheresh DA. Role of integrins in cell invasion and migration. Nat Rev Cancer. 2002;2:91-100. (Pubitemid 37328796)
6. Stupack DG, Cheresh DA. Integrins and angiogenesis. Curr Top Dev Biol. 2004;64:207-238.
7. Ellegala DB, Leong-Poi H, Carpenter JE, et al. Imaging tumor angiogenesis with contrast ultrasound and microbubbles targeted to alpha(v)beta3. Circulation. 2003;108:336-341.
8. Palmowski M, Huppert J, Ladewig G, et al. Molecular profiling of angiogenesis with targeted ultrasound imaging: early assessment of antiangiogenic therapy effects. Mol Cancer Ther. 2008;7:101-109.
9. Willmann JK, Lutz AM, Paulmurugan R, et al. Dual-targeted contrast agent for US assessment of tumor angiogenesis in vivo. Radiology. 2008;248:936-944.
10. Kolmar H. Alternative binding proteins: biological activity and therapeutic potential of cystine-knot miniproteins. FEBS J. 2008;275:2684-2690. (Pubitemid 351678680)
11. Favel A, Mattras H, Coletti-Previero MA, Zwilling R, Robinson EA, Castro B. Protease inhibitors from Ecballium elaterium seeds. Int J Pept Protein Res. 1989;33:202-208. (Pubitemid 19095142)
12. Kimura RH, Levin AM, Cochran FV, Cochran JR. Engineered cystine knot peptides that bind alphavbeta3, alphavbeta5, and alpha5beta1 integrins with low-nanomolar affinity. Proteins. 2009;77:359-369.
13. Villanueva FS, Jankowski RJ, Klibanov S, et al. Microbubbles targeted to intercellular adhesion molecule-1 bind to activated coronary artery endothelial cells. Circulation. 1998;98:1-5. (Pubitemid 28312070)
14. Lindner JR, Song J, Xu F, et al. Noninvasive ultrasound imaging of inflammation using microbubbles targeted to activated leukocytes. Circulation. 2000;102:2745-2750.
15. Weller GE, Wong MK, Modzelewski RA, et al. Ultrasonic imaging of tumor angiogenesis using contrast microbubbles targeted via the tumor-binding peptide arginine-arginine-leucine. Cancer Res. 2005;65:533-539.
16. Willmann JK, Paulmurugan R, Chen K, et al. US imaging of tumor angiogenesis with microbubbles targeted to vascular endothelial growth factor receptor type 2 in mice. Radiology. 2008;246:508-518.
17. Palmowski M, Morgenstern B, Hauff P, et al. Pharmacodynamics of streptavidin-coated cyanoacrylate microbubbles designed for molecular ultrasound imaging. Invest Radiol. 2008;43:162-169. (Pubitemid 351643142)
18. Willmann JK, Cheng Z, Davis C, et al. Targeted microbubbles for imaging tumor angiogenesis: assessment of whole-body biodistribution with dynamic micro-PET in mice. Radiology. 2008;249:212-219.
19. Korpanty G, Carbon JG, Grayburn PA, Fleming JB, Brekken RA. Monitoring response to anticancer therapy by targeting microbubbles to tumor vasculature. Clin Cancer Res. 2007;13:323-330. (Pubitemid 46121886)
20. Lyshchik A, Fleischer AC, Huamani J, Hallahan DE, Brissova M, Gore JC. Molecular imaging of vascular endothelial growth factor receptor 2 expression using targeted contrast-enhanced high-frequency ultrasonography. J Ultrasound Med. 2007;26:1575-1586. (Pubitemid 351519803)
21. Rychak JJ, Graba J, Cheung AM, et al. Microultrasound molecular imaging of vascular endothelial growth factor receptor 2 in a mouse model of tumor angiogenesis. Mol Imaging. 2007;6:289-296. (Pubitemid 350013534)
22. Craik DJ, Clark RJ, Daly NL. Potential therapeutic applications of the cyclotides and related cystine knot mini-proteins. Expert Opin Investig Drugs. 2007;16:595-604.
23. Chiche L, Heitz A, Gelly JC, et al. Squash inhibitors: from structural motifs to macrocyclic knottins. Curr Protein Pept Sci. 2004;5:341-349. (Pubitemid 39200164)
24. Maillere B, Mourier G, Herve M, Cotton J, Leroy S, Menez A. Immunogenicity of a disulfide-containing neurotoxin: presentation to T-cells requires a reduction step. Toxicon. 1995;33:475-482.
25. Brown CK, Modzelewski RA, Johnson CS, Wong MK. A novel approach for the identification of unique tumor vasculature binding peptides using an E. coli peptide display library. Ann Surg Oncol. 2000;7:743-749.
26. Zhou Y, Drummond DC, Zou H, et al. Impact of single-chain Fv antibody fragment affinity on nanoparticle targeting of epidermal growth factor receptor-expressing tumor cells. J Mol Biol. 2007;371:934-947. (Pubitemid 47103290)
27. Dijkgraaf I, Kruijtzer JA, Liu S, et al. Improved targeting of the alpha(v)beta (3) integrin by multimerisation of RGD peptides. Eur J Nucl Med Mol Imaging. 2007;34:267-273.