IgG-enzyme fusion protein: Pharmacokinetics and anti-drug antibody response in rhesus monkeys

Bioconjugate Chemistry

Volumn 24, Issue 1, 2013, Pages 97-104

  Boado, Ruben J ^a,b   Hui, Eric Ka Wai ^b   Lu, Jeff Zhiqiang ^b   Pardridge, William M ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b ArmaGen Technologies Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DRUG DOSAGE; ENZYME ACTIVITY; IMMUNE SYSTEM; INSULIN; MAMMALS; MONOCLONAL ANTIBODIES; RECOMBINANT PROTEINS; TISSUE; TOXICITY;

ANIMAL MODEL; ANTIBODIES RESPONSE; BLOOD-BRAIN BARRIER; FUSION PROTEINS; HUMAN INSULINS; IMMUNE RESPONSE; INSULIN RECEPTORS; LYSOSOMAL ENZYMES; PLASMA CLEARANCES; RHESUS MONKEY;

PHARMACOKINETICS;

DRUG ANTIBODY; HUMAN INSULIN RECEPTOR MONOCLONAL ANTIBODY IDURONIDASE FUSION PROTEIN; HYBRID PROTEIN; IMMUNOGLOBULIN G; INSULIN RECEPTOR; LEVO IDURONIDASE; MONOCLONAL ANTIBODY; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANTIBODY RESPONSE; ARTICLE; BLOOD BRAIN BARRIER; CONTROLLED STUDY; DRUG HYPERSENSITIVITY; DRUG MEGADOSE; DYSPNEA; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HOT FLUSH; LOW DRUG DOSE; MALE; MUCOPOLYSACCHARIDOSIS; NONHUMAN; PLASMA CLEARANCE; PROTEIN DOMAIN; RHESUS MONKEY;

ANIMALIA; EQUIDAE; MACACA MULATTA; PRIMATES;

EID: 84872588784     PISSN: 10431802     EISSN: 15204812     Source Type: Journal    
DOI: 10.1021/bc3005123     Document Type: Article

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