Computational protein design to reengineer stromal cell-derived factor-1α generates an effective and translatable angiogenic polypeptide analog

Circulation

Volumn 124, Issue 11 SUPPL. 1, 2011, Pages

  Hiesinger, William ^a   Perez Aguilar, Jose Manuel ^a,c   Atluri, Pavan ^a   Marotta, Nicole A ^a   Frederick, John R ^a   Fitzpatrick, J Raymond ^a   McCormick, Ryan C ^a   Muenzer, Jeffrey R ^a   Yang, Elaine C ^a   Levit, Rebecca D ^d   Yuan, Li Jun ^b   MacArthur, John W ^a   Saven, Jeffery G ^c   Woo, Y Joseph ^a  

^a Division of Cardiovascular Surgery   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

^d EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

angiogenesis; cardiac surgery; computational biology; computer models; endothelial cells; progenitor cells

Indexed keywords

ANGIOPOIETIN 1; ENGINEERED SDF POLYPEPTIDE ANALOG; POLYPEPTIDE; PROTEIN KINASE B; STROMAL CELL DERIVED FACTOR 1ALPHA; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL MIGRATION; COMPUTATIONAL PROTEIN DESIGN; CONFORMATION; CONTROLLED STUDY; DRUG MECHANISM; ENDOTHELIAL PROGENITOR CELL; HEART LEFT VENTRICLE EJECTION FRACTION; HEART OUTPUT; HEART STROKE VOLUME; LEFT ANTERIOR DESCENDING CORONARY ARTERY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN ENGINEERING; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN STRUCTURE; QUANTITATIVE ANALYSIS; RAT; TRANSTHORACIC ECHOCARDIOGRAPHY;

ANGIOGENIC PROTEINS; ANIMALS; CARDIAC OUTPUT; CELL MOVEMENT; CELLS, CULTURED; CHEMOKINE CXCL12; COMPUTATIONAL BIOLOGY; CORONARY VESSELS; ENDOTHELIAL CELLS; MALE; MICE; MICE, INBRED STRAINS; MODELS, ANIMAL; MYOCARDIAL INFARCTION; NEOVASCULARIZATION, PHYSIOLOGIC; PROTEIN ENGINEERING; RATS; RATS, WISTAR; STEM CELLS; STROKE VOLUME;

EID: 80052767490     PISSN: 00097322     EISSN: 15244539     Source Type: Journal    
DOI: 10.1161/CIRCULATIONAHA.110.009431     Document Type: Article

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